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Rheumatic fever without mention of heart involvement

DOID EFO Endpoint Browser PheWeb

I9_RHEUFEVWITHOUTHEART

rheumatic fever: Rheumatic fever (RF) is a multisystem inflammatory disease occurring as a post-infectious, nonsuppurative sequela of untreated streptococcus pyogenes (Group A streptococcus [GAS]) pharyngitis, and mainly occurs in individuals aged 5 to 15 years. The most common presenting signs are fever, migratory polyarthritis and carditis.

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

137

4. Check minimum number of events

None

137

5. Include endpoints

None

137

6. Filter based on genotype QC (FinnGen only)

120

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1291 714 563
Only index persons 971 550 421
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 36.50 39.46 32.27
Only index persons 30.76 33.43 27.27

-FinnGen-

Key figures

All Female Male
Number of individuals 120 67 53
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 27.76 28.88 26.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
122
Matched controls
1220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
39097
ICD-8 Finland
Rheumatic fever without mention of heart involvement, Suspecta
+∞
43.3
39
*
39099
ICD-8 Finland
Rheumatic fever without mention of heart involvement, Unspecified
+∞
27.1
25
*
I00
ICD-10 Finland
Rheumatic fever without mention of heart involvement
+∞
27.1
25
*
L54.0*I00
ICD-10 Finland
Erythema marginatum in acute rheumatic fever
+∞
8.4
8
*
I02.9
ICD-10 Finland
Rheumatic chorea without heart involvement
+∞
7.4
7
*
3900A
ICD-9 Finland
Rheumatic fever without mention of heart involvement[FEBRIS RHEUMATICA, MORBO CORDIS NON INDICATO]
+∞
7.4
7
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
19
93
2.24
2.37
11.3
9.5
—
—
—
0
0
23
122
2.09
2.36
10.2
8.4
7.43
7.42
ph
0.43
12
71
23
126
2.02
2.17
2.0
1.7
—
—
—
0
0
63
489
1.60
1.76
14.3
12.4
1.24
1.19
inr
0.30
55
400
28
179
1.73
1.65
3.2
2.9
13.00
13.52
umol/l
0.16
28
165
13
68
2.02
1.39
17.1
7.6
24.89
25.02
mmol/l
0.06
13
68
47
356
1.52
1.39
4.6
3.4
7.18
7.96
mmol/l
0.56
40
295
46
348
1.52
1.36
5.0
4.3
2.69
9.68
mg/mmol
2.23
32
222
12
63
2.00
1.28
3.2
4.3
—
—
—
0
0
45
347
1.47
1.19
4.0
3.5
16.36
53.37
mg/l
2.67
30
227
0
33
0.00
1.18
0.0
1.1
—
0.76
—
0
5
0
34
0.00
1.18
0.0
1.2
—
1.57
—
0
34
14
224
0.58
1.12
3.9
3.1
0.89
0.83
ug/l
—
8
146
67
562
1.43
1.12
10.1
7.2
0.20
0.19
e9/l
0.20
62
504
17
107
1.68
1.06
2.9
4.3
7.39
7.39
ph
—
9
66
5
22
2.33
1.04
8.0
3.5
—
—
—
0
0
17
109
1.65
1.00
12.9
8.9
122.06
119.38
g/l
0.25
17
109
7
36
2.00
0.99
2.7
1.8
0.18
0.23
g/l
—
7
36
7
36
2.00
0.99
2.7
1.9
1.05
1.17
g/l
—
7
36
45
359
1.40
0.97
9.5
5.8
—
—
—
0
0
25
178
1.51
0.96
2.2
1.7
1646.80
1270.07
nmol/l
0.70
20
142
38
296
1.41
0.93
5.9
4.4
—
—
—
0
0
41
325
1.39
0.91
2.7
2.1
148.76
210.33
u/l
0.46
41
307
21
146
1.53
0.90
1.6
1.4
448.00
555.90
titre
—
5
39
71
616
1.37
0.90
13.2
11.1
4.10
4.08
e9/l
0.03
64
543
39
310
1.38
0.85
4.7
3.2
0.53
0.43
e6/l
0.13
33
230
13
83
1.63
0.78
2.3
2.2
3.53
7.15
ug/l
1.56
13
74
0
27
0.00
0.78
0.0
1.6
—
—
—
0
0
64
557
1.31
0.75
9.5
7.0
1.98
1.84
e9/l
0.57
59
503
88
801
1.35
0.75
10.5
8.5
73.37
79.31
u/l
1.18
83
753
63
549
1.31
0.72
9.5
7.0
0.05
0.04
e9/l
0.87
58
479
53
452
1.31
0.71
2.1
2.0
1.24
1.37
mmol/l
0.71
45
373
40
328
1.33
0.70
3.0
2.4
—
—
—
0
0
26
199
1.39
0.70
5.1
3.7
2615.25
339.42
ng/l
0.41
20
163
7
42
1.71
0.69
1.4
1.9
—
—
—
0
0
38
310
1.33
0.69
2.9
2.9
361.10
334.58
umol/l
0.89
31
266
44
368
1.31
0.67
3.8
3.3
—
—
—
0
0
5
28
1.82
0.67
1.6
1.2
—
—
—
0
0
43
359
1.31
0.66
5.1
3.3
11.95
35.41
e6/l
1.42
38
281
51
436
1.29
0.66
1.9
2.0
—
—
—
0
0
101
946
1.39
0.65
4.8
5.2
1.75
1.93
mu/l
1.36
93
862
11
71
1.60
0.64
1.0
1.6
—
—
—
0
0
62
545
1.28
0.64
9.7
7.0
0.59
0.58
e9/l
0.28
55
479
20
149
1.41
0.63
11.7
7.5
104.05
103.64
mmol/l
0.18
20
149
25
194
1.36
0.62
1.4
1.4
1.56
7.79
u/ml
—
9
73
22
167
1.39
0.62
3.5
2.9
2.51
2.30
g/l
0.92
22
150
5
30
1.69
0.62
3.0
2.2
71.88
58.26
%
—
5
30
21
159
1.39
0.60
3.6
2.9
20.70
23.03
%
0.43
21
147
0
23
0.00
0.59
0.0
2.1
—
—
—
0
0
0
23
0.00
0.59
0.0
1.2
—
—
—
0
0
9
60
1.54
0.56
2.9
4.0
24.77
24.58
mmol/l
—
9
60
9
63
1.46
0.54
3.6
2.8
0.70
0.62
%
—
9
63
9
64
1.44
0.53
3.6
2.8
1.22
1.15
%
—
9
64
21
163
1.35
0.53
4.0
3.0
2.64
2.63
e6/l
0.00
11
84
55
486
1.24
0.52
3.0
2.8
—
—
estimate
—
0
0
14
102
1.42
0.50
1.4
1.6
—
—
—
0
0
39
333
1.25
0.49
5.4
4.5
7.40
7.40
ph
0.08
32
236
55
491
1.22
0.46
17.4
12.9
0.00
0.00
e9/l
0.50
46
403
47
414
1.22
0.45
5.3
4.0
153.37
66.57
e6/l
0.32
39
297
6
91
0.64
0.44
1.2
2.0
3.05
3.47
mmol/l
—
6
72
52
464
1.21
0.43
2.2
2.0
96.07
97.27
pmol/l
0.04
23
213
5
32
1.59
0.43
1.0
1.1
—
—
—
0
0
17
133
1.32
0.41
1.7
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
18
144
1.29
0.38
7.6
6.2
1.10
1.04
mmol/l
0.57
18
131
16
126
1.31
0.37
1.3
1.3
—
—
—
0
0
14
109
1.32
0.35
1.7
1.6
—
—
—
0
0
29
332
0.83
0.32
6.0
4.0
0.00
0.00
estimate
-0.00
16
116
16
129
1.28
0.32
1.7
1.4
—
—
—
0
0
37
328
1.18
0.32
3.8
2.8
—
—
—
0
0
105
1080
0.80
0.29
35.1
25.5
132.59
135.19
g/l
0.98
105
1068
29
254
1.19
0.29
6.0
6.9
—
—
—
0
0
105
1079
0.81
0.28
34.6
25.2
30.29
30.37
pg
0.20
105
1067
105
1079
0.81
0.28
35.3
25.8
39.32
40.47
%
0.98
105
1067
19
223
0.82
0.27
1.2
1.4
3.64
2.88
g/l
0.38
14
129
5
74
0.66
0.27
1.4
2.1
—
—
—
0
0
105
1078
0.81
0.26
34.6
25.3
91.41
91.33
fl
0.07
105
1066
19
161
1.21
0.26
1.6
1.7
—
—
—
0
0
102
990
1.18
0.23
22.2
16.7
21.24
23.34
mg/l
0.31
87
814
8
102
0.77
0.22
1.1
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
571.17
—
0
6
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
100
971
1.17
0.21
7.4
6.4
40.61
39.78
mmol/mol
0.28
95
907
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
6
49
1.24
0.20
9.0
2.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
66
627
1.11
0.20
7.6
4.9
6.58
6.68
mmol/l
0.18
61
597
36
330
1.13
0.20
14.1
6.4
—
—
—
0
0
21
236
0.87
0.19
1.0
1.3
0.85
1.51
u/ml
—
6
63
100
1023
0.88
0.17
19.8
14.6
—
—
—
0
0
30
276
1.12
0.15
1.4
1.5
—
—
—
0
0
13
112
1.18
0.15
1.8
1.6
—
—
—
0
0
21
189
1.13
0.15
2.7
2.8
0.83
0.82
mmol/l
0.20
21
178
10
84
1.21
0.14
1.2
2.3
13.20
10.13
g/l
—
10
79
12
103
1.18
0.14
1.3
1.3
—
—
—
0
0
8
98
0.80
0.14
9.8
4.0
—
—
—
0
0
97
990
0.90
0.13
6.1
5.1
6.03
5.96
mmol/l
0.21
90
903
13
115
1.15
0.11
1.9
2.0
332.46
410.72
nmol/l
1.15
13
106
5
48
1.04
0.09
1.0
1.1
—
—
—
0
0
6
56
1.08
0.09
2.7
2.3
—
—
—
0
0
5
62
0.80
0.08
1.2
1.1
—
—
—
0
0
7
66
1.06
0.08
2.0
1.5
—
—
—
0
0
7
67
1.05
0.08
1.3
1.3
—
—
—
0
0
7
68
1.03
0.08
3.0
5.2
91.76
82.26
ng/l
—
7
56
101
1023
0.93
0.07
6.5
6.0
2.60
2.69
mmol/l
0.44
96
938
45
435
1.05
0.06
4.8
3.8
29.14
42.59
ng/l
0.67
36
310
26
247
1.07
0.06
6.2
4.1
1.01
1.02
kg/l
0.73
15
155
14
130
1.09
0.05
1.3
1.2
—
—
—
0
0
45
438
1.04
0.04
4.8
4.0
0.00
0.02
estimate
0.50
13
105
48
469
1.04
0.04
4.1
3.7
5.67
6.13
ph
2.31
24
259
17
161
1.06
0.03
1.2
1.3
—
—
—
0
0
59
598
0.97
0.02
4.7
4.0
0.00
0.03
estimate
0.50
14
119
12
127
0.94
0.01
8.7
3.5
2.27
1.93
%
0.33
12
114
32
327
0.97
0.01
3.8
3.4
0.00
0.00
estimate
-0.00
13
105
15
156
0.96
0.00
3.0
2.1
—
—
—
0
0
59
584
1.02
0.00
4.6
3.9
0.00
0.00
estimate
-0.00
16
124
22
217
1.02
0.00
1.4
1.3
9.80
33.32
iu/ml
—
5
67
59
593
0.99
0.00
4.7
3.9
0.00
0.00
estimate
-0.00
16
127
10
95
1.06
0.00
1.8
1.3
—
—
—
0
0
42
424
0.99
0.00
2.6
3.3
—
—
—
0
0
96
964
0.98
0.00
4.8
4.4
1.42
1.28
mmol/l
0.83
91
880
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
55.86
—
0
7
0
7
0.00
-0.00
0.0
20.0
—
1627.71
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
25.33
—
0
6
0
7
0.00
-0.00
0.0
14.3
—
786.57
—
0
7
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
3.13
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
71
0.99
-0.00
1.7
1.3
—
28.25
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
1.1
1.7
1.38
1.17
g/l
—
7
65
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
144.78
—
0
6
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint I9_RHEUFEVWITHOUTHEART and mortality.

Females

Parameter HR [95% CI] p-value
I9_RHEUFEVWITHOUTHEART 2.023 [1.5, 2.72] < 0.001
Birth year 0.999 [0.99, 1.01] 0.863

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 253 females with I9_RHEUFEVWITHOUTHEART died.

Males

Parameter HR [95% CI] p-value
I9_RHEUFEVWITHOUTHEART 1.981 [1.33, 2.95] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 180 males with I9_RHEUFEVWITHOUTHEART died.

Mortality risk

Mortality risk for people of age

years, who have I9_RHEUFEVWITHOUTHEART.

N-year risk Females Males
1 0.15% 0.323%
5 1.268% 2.127%
10 3.63% 5.092%
15 6.593% 9.279%
20 11.567% 15.75%

Relationships between endpoints

↥

Index endpoint: I9_RHEUFEVWITHOUTHEART – Rheumatic fever without mention of heart involvement

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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