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Circumscribed brain atrophy

DOID EFO Endpoint Browser PheWeb

G6_ATROPHCIRCUM

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G31.0
  • Hospital discharge: ICD-9 — 3311
  • Hospital discharge: ICD-8 — 34791
  • Cause of death: ICD-10 — G31.0
  • Cause of death: ICD-9 — 3311
  • Cause of death: ICD-8 — 34791

2 out of 7 registries used, show all original rules.

934

4. Check minimum number of events

None

934

5. Include endpoints

None

934

6. Filter based on genotype QC (FinnGen only)

825

Control definitions (FinnGen only)

Control exclude
G6_NEURODEG

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF6
Parent code in ICD-10
G31
Name in latin
Atrophia cerebri circumscripta

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9185 4538 4462
Only index persons 6588 3580 3008
Unadjusted period prevalence (%)
Whole population 0.13 0.13 0.12
Only index persons 0.12 0.13 0.11
Median age at first event (years)
Whole population 66.45 69.56 63.74
Only index persons 69.18 70.86 67.17

-FinnGen-

Key figures

All Female Male
Number of individuals 825 376 449
Unadjusted period prevalence (%) 0.17 0.13 0.21
Median age at first event (years) 68.86 69.17 68.60

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
850
Matched controls
8500
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G31.0
ICD-10 Finland
Circumscribed brain atrophy
5781.5
307.7
625
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
11.5
257.9
349
487
N05AX08
ATC
risperidone; systemic
12.4
231.2
271
308
XA800
NOMESCO Finland
Neuropsychological investigation
20.5
215.5
175
106
F03
ICD-10 Finland
Unspecified dementia
13.9
199.9
206
191
F02.09*G31.0
ICD-10 Finland
Dementia in Pick's disease without information on additional symptoms
+∞
191.0
176
*
TAB00
NOMESCO Finland
Lumbar puncture
15.8
187.6
175
137
N06DX01
ATC
memantine; oral
11.2
136.5
157
168
N05AH03
ATC
olanzapine; systemic
11.0
130.3
151
163
N05AH04
ATC
quetiapine; oral
6.1
127.6
292
673
34791
ICD-8 Finland
Other disease of brain, Atrophia cerebri
+∞
124.1
116
*
N06DA02
ATC
donepezil; oral
10.3
111.0
134
152
P70
ICPC
Dementia
16.1
106.5
94
65
P20
ICPC
Memory disturbance
5.1
105.8
301
824
N03AG01
ATC
valproic acid; systemic, rectal
8.8
104.9
144
192
G30.1
ICD-10 Finland
Alzheimer disease with late onset
13.5
102.0
100
83
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
58.7
97.5
55
10
N06DA03
ATC
rivastigmine; oral, transdermal
9.4
77.9
98
116
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
6.5
76.0
137
244
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
20.7
75.2
58
30
Z2445
NOMESCO Finland
Psychologist
10.3
68.8
80
85
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.0
68.5
170
404
R41.3
ICD-10 Finland
Other amnesia
8.9
66.4
87
108
A28
ICPC
Limited function/disability NOS
3.6
65.9
320
1232
F06.7
ICD-10 Finland
Mild cognitive disorder
7.2
57.1
89
135
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
300.6
55.9
56
*
N05BA06
ATC
lorazepam; systemic, sublingual
5.4
54.8
117
242
N19
ICPC
Speech disorder
12.3
47.6
48
41
R47.0
ICD-10 Finland
Dysphasia and aphasia
12.7
47.4
47
39
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
5.1
47.3
107
232
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
121.4
43.2
46
*
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
12.5
43.1
43
36
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.3
42.2
90
185
N05BA04
ATC
oxazepam; oral
2.8
41.6
305
1425
N06AX11
ATC
mirtazapine; oral
2.6
38.3
364
1919
N06AB10
ATC
escitalopram; oral
3.1
37.5
197
764
N05AD01
ATC
haloperidol; systemic
6.2
37.1
66
114
F02.09
ICD-10 Finland
Dementia in Pick's disease without information on additional symptoms
+∞
36.7
35
*
R41.0
ICD-10 Finland
Disorientation, unspecified
5.9
36.0
67
121
G30.0
ICD-10 Finland
Alzheimer disease with early onset
361.5
35.2
35
*
IGY02
NOMESCO Finland
Psychiatric monitoring contact
8.9
34.6
44
52
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
12.1
34.5
35
30
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
4.1
33.9
101
271
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.4
33.6
90
223
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
6.9
32.2
51
78
G40.9
ICD-10 Finland
Epilepsy, unspecified
5.5
31.4
63
122
F29
ICD-10 Finland
Unspecified nonorganic psychosis
7.1
31.3
48
71
WYA20
NOMESCO Finland
Home visit
7.3
29.5
44
63
N99
ICPC
Neurological disease other
10.1
28.7
33
34
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.2
28.6
126
437
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
9.5
28.4
34
37
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
10.0
27.8
32
33
N05AX12
ATC
aripiprazole; systemic
7.4
27.8
41
58
AA1AD
NOMESCO Finland
CT of head and brain
2.2
27.6
347
2001
R4130
NOMESCO Finland
Speech therapy
5.8
27.1
51
93
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
26.3
353
2079
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
25.6
255
1328
G30.8
ICD-10 Finland
Other Alzheimer disease
29.4
25.5
34
12
ZY010
NOMESCO Finland
Hospital outpatient
4.7
25.4
61
138
F22.0
ICD-10 Finland
Delusional disorder
9.2
25.2
31
35
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
7.3
23.5
35
50
SPAT1053
SPAT
Memory test
2.4
23.4
189
893
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.0
22.9
111
405
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
3.9
22.8
70
191
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.1
22.8
103
361
AA5DR
NOMESCO Finland
Brain metabolism PET with CT
236.1
22.7
23
*
F05.9
ICD-10 Finland
Delirium, unspecified
5.2
22.1
46
92
SPAT1216
SPAT
Assessment of functional ability
2.3
22.1
195
957
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
7.0
21.4
33
49
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
4.2
21.3
59
149
ZY000
NOMESCO Finland
Hospital inpatient
9.2
21.3
26
29
S01.0
ICD-10 Finland
Open wound of scalp
2.9
21.0
111
424
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
61.6
21.0
24
*
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
7.3
20.9
31
44
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.8
19.9
64
180
F0200, G310,
ICD-10 Finland
+∞
19.9
19
*
F0203, G310,
ICD-10 Finland
+∞
19.9
19
*
N03AE01
ATC
clonazepam; systemic
3.3
19.1
74
236
IBZ07
NOMESCO Finland
Neurological assessment in psychiatry
56.4
19.0
22
*
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
5.7
19.0
36
66
N06AB04
ATC
citalopram; systemic
2.2
19.0
209
1116
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.7
18.4
59
166
A06AD11
ATC
lactulose; oral
2.2
18.2
195
1029
N06AX26
ATC
vortioxetine; oral
3.4
18.0
66
203
R53
ICD-10 Finland
Malaise and fatigue
2.0
18.0
246
1421
F0204, G310,
ICD-10 Finland
+∞
17.8
17
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.5
17.7
64
195
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
19.1
17.4
26
14
N06DA04
ATC
galantamine; oral
5.5
16.9
33
62
A04
ICPC
Weakness/tiredness general
2.2
16.9
163
823
P29
ICPC
Psychological sympt/compl other
3.7
16.8
55
157
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
7.5
16.6
24
33
P99
ICPC
Psychological disorders other
5.2
16.6
34
67
IAB14
NOMESCO Finland
Geriatric psychiatry consultation
30.7
16.2
21
7
G31.1
ICD-10 Finland
Senile degeneration of brain, not elsewhere classified
86.7
15.6
17
*
G31
ICD-10 Finland
Other degenerative diseases of nervous system, not elsewhere classified
162.9
15.5
16
*
U04
ICPC
Incontinence urine
2.8
15.4
83
319
N03AX09
ATC
lamotrigine; oral
3.9
15.0
44
116
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.2
14.8
61
202
ZXY02
NOMESCO Finland
Neuropsychologist
25.5
14.7
20
8
F02.00
ICD-10 Finland
Dementia in Pick's disease without additional symptoms
+∞
14.6
14
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
14.6
171
926
W19
ICD-10 Finland
Unspecified fall
2.4
14.4
111
507
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
6.1
14.4
25
42
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
5.7
14.4
27
49
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
43.3
14.1
17
*
A29
ICPC
General symptom/complaint other
2.1
14.1
149
776
N05AN01
ATC
lithium; oral
5.4
13.8
27
51
N29
ICPC
Neurological sympt/complt other
5.2
13.7
28
55
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
5.7
13.4
25
45
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.2
13.4
36
89
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
10.7
13.3
25
24
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
11.2
13.1
24
22
S06.0
ICD-10 Finland
Concussion
2.3
13.1
109
515
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
5.2
12.7
26
51
P74
ICPC
Anxiety disorder/anxiety state
4.1
12.7
35
88
G12.2
ICD-10 Finland
Motor neuron disease
10.3
12.5
24
24
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
4.8
12.4
28
60
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.9
12.4
59
212
R1250
NOMESCO Finland
Evaluation of functional capability
4.3
12.3
32
77
183
Kela drug reimbursment
Lamotrigin and topiramate
14.6
12.3
20
14
N05AF03
ATC
chlorprothixene; systemic
4.5
12.2
30
69
N28
ICPC
Limited function/disability (N)
4.6
12.2
29
65
G30
ICD-10 Finland
Alzheimer disease
18.4
12.1
18
10
IGY99
NOMESCO Finland
Other psychiatric treatment contact
9.5
12.0
24
26
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
6.0
11.8
21
36
N05AL01
ATC
sulpiride; systemic
6.0
11.8
21
36
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
0.4
11.7
81
1652
R4130, ,
SPAT
19.2
11.6
17
9
ZXY03
NOMESCO Finland
Occupational therapist
+∞
11.5
11
*
N06AX16
ATC
venlafaxine; oral
2.1
11.4
111
557
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
15.3
11.3
18
12
78020
ICD-8 Finland
Certain symptoms referable to nervous system and special senses, Convulsions
15.3
11.3
18
12
RT250, ,
NOMESCO Finland
35.5
11.3
14
*
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.8
11.3
57
212
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
11.3
280
1903
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
5.6
11.2
21
38
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.4
11.0
79
349
L28
ICPC
Limited function/disability (L)
1.8
11.0
204
1276
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.7
10.9
59
227
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.0
10.9
50
176
Z02.4
ICD-10 Finland
Examination for driving licence
0.5
10.9
119
2071
N03AX14
ATC
levetiracetam; systemic
3.9
10.8
32
85
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
5.2
10.8
22
43
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
10.8
143
803
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
28.4
10.7
14
5
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
3.6
10.7
35
100
N02AA05
ATC
oxycodone; systemic
1.8
10.7
201
1261
SPAT1234
SPAT
Support of social functional capacity
2.6
10.6
60
237
N05AA02
ATC
levomepromazine; systemic
3.1
10.6
45
152
F0201, G310,
ICD-10 Finland
+∞
10.4
10
*
F0202, G310,
ICD-10 Finland
+∞
10.4
10
*
F02.04
ICD-10 Finland
Dementia in Pick's disease other additional symptoms of mixed type
+∞
10.4
10
*
N05CD07
ATC
temazepam; oral
1.9
10.4
136
760
N05BA01
ATC
diazepam; systemic, rectal
2.0
10.2
128
705
P28
ICPC
Limited function/disability (P)
13.3
10.2
17
13
IAB01
NOMESCO Finland
Psychiatric pharmacotherapy consultation
11.5
10.1
18
16
RT150, ,
NOMESCO Finland
40.6
10.0
12
*
Z3226
NOMESCO Finland
Physiotherapist
1.8
9.9
170
1035
F80.1
ICD-10 Finland
Expressive language disorder
9.7
9.8
19
20
N06AB06
ATC
sertraline; oral
2.2
9.8
84
401
Z02.7
ICD-10 Finland
Issue of medical certificate
2.4
9.6
70
311
R47.8
ICD-10 Finland
Other and unspecified speech disturbances
5.1
9.6
20
40
F20.9
ICD-10 Finland
Schizophrenia, unspecified
4.9
9.6
21
44
P76
ICPC
Depressive disorder
2.9
9.5
45
162
N05AH02
ATC
clozapine; systemic
7.7
9.5
21
28
F06.4
ICD-10 Finland
Organic anxiety disorder
101.1
9.4
10
*
ZXY01
NOMESCO Finland
Chief Physician, Head of Department or Deputy Chief Physician
17.8
9.4
14
8
F062, G310,
ICD-10 Finland
+∞
9.4
9
*
F064, G310,
ICD-10 Finland
+∞
9.4
9
*
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
2.9
9.4
45
163
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.2
9.3
77
362
N05CF01
ATC
zopiclone; oral
1.6
9.1
301
2175
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
9.1
76
359
ZYB04
NOMESCO Finland
Outreach service in patient’s home or everyday environment
18.8
8.9
13
7
R55
ICD-10 Finland
Syncope and collapse
1.9
8.9
121
683
F00.9
ICD-10 Finland
Dementia in Alzheimer disease, unspecified
24.3
8.9
12
5
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.1
8.9
36
118
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.0
8.8
95
496
N05AB03
ATC
perphenazine; systemic, rectal
3.2
8.8
35
114
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.1
8.6
35
115
G40
ICD-10 Finland
Epilepsy
8.3
8.6
18
22
IGP01
NOMESCO Finland
Psychiatric family contact
16.5
8.6
13
8
N03AF02
ATC
oxcarbazepine; oral
3.4
8.5
30
90
IBZ02
NOMESCO Finland
Somatic assessment of psychiatric patient
27.8
8.5
11
*
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
4.2
8.5
22
53
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
8.5
149
911
-, ,
ICD-10 Finland
3.5
8.4
29
86
ZX120, ,
SPAT
4.7
8.4
19
41
F0633, G310,
ICD-10 Finland
+∞
8.3
8
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
3.9
8.3
24
63
A27
ICPC
Fear of other disease NOS
2.5
8.2
53
223
D21
ICPC
Swallowing problem
4.0
8.2
23
59
F61.0
ICD-10 Finland
Mixed personality disorders
8.2
8.1
17
21
F22.9
ICD-10 Finland
Persistent delusional disorder, unspecified
11.8
8.1
14
12
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.3
8.0
58
258
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
8.0
149
926
AA400
NOMESCO Finland
Electroconvulsive therapy
13.2
7.9
13
10
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
3.8
7.8
23
61
SPAT1229
SPAT
Assessment of need for aid
2.0
7.8
81
417
P72
ICPC
Schizophrenia
4.2
7.8
20
48
SPAT1307
SPAT
Psychosocial counselling and guidance
3.3
7.7
29
91
SPAT1254
SPAT
Administration of medicine
1.8
7.7
137
839
SPAT1101
SPAT
Orthostatic test
2.4
7.7
50
212
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.7
7.6
24
67
G20
ICD-10 Finland
Parkinson disease
2.6
7.5
41
160
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.5
7.4
46
191
Z75.5
ICD-10 Finland
Holiday relief care
6.9
7.3
17
25
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
6.9
7.3
17
25
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
11.0
7.3
13
12
IFB01
NOMESCO Finland
Electroconvulsive Therapy (ECT)
11.0
7.3
13
12
IGV01
NOMESCO Finland
Psychiatric network contact
11.0
7.3
13
12
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
4.2
7.3
19
46
F0019, G301,
ICD-10 Finland
+∞
7.3
7
*
WW200, ,
SPAT
0.6
7.3
118
1866
Z2446
NOMESCO Finland
Social worker
2.2
7.2
61
290
R44.3
ICD-10 Finland
Hallucinations, unspecified
8.0
7.1
15
19
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
4.3
7.0
18
43
F10.20
ICD-10 Finland
Alcohol dependence currently independent
3.8
6.9
21
57
S72.0
ICD-10 Finland
Fracture of neck of femur
2.3
6.9
52
235
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
7.6
6.9
15
20
P98
ICPC
Psychosis NOS/other
13.9
6.9
11
8
N05BE01
ATC
buspirone; oral
3.1
6.8
28
93
F31.3
ICD-10 Finland
Bipolar affective disorder, current episode mild or moderate depression
9.4
6.8
13
14
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
5.7
6.8
18
32
F07.0
ICD-10 Finland
Organic personality disorder
40.4
6.8
8
*
F23.99
ICD-10 Finland
Acute and transient psychosis, unspecified UNS
40.4
6.8
8
*
SPAT1246
SPAT
Screening of depression or other psychiatric problem
3.6
6.7
22
63
R25.1
ICD-10 Finland
Tremor, unspecified
2.8
6.7
33
122
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
7.9
6.6
14
18
34599
ICD-8 Finland
Epilepsy, Other and unspecified
10.1
6.5
12
12
F05.1
ICD-10 Finland
Delirium superimposed on dementia
10.1
6.5
12
12
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
6.9
6.5
15
22
N02AJ06
ATC
codeine and paracetamol; systemic
0.6
6.5
183
2547
ZXE22
NOMESCO Finland
Procedure duration at least 4 but less than 5 hours
70.4
6.4
7
*
F31
ICD-10 Finland
Bipolar affective disorder
7.5
6.4
14
19
N03AF01
ATC
carbamazepine; oral, rectal
2.2
6.4
55
264
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
2.6
6.4
35
137
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.6
6.3
37
149
P27
ICPC
Fear of mental disorder
8.2
6.3
13
16
R32
ICD-10 Finland
Unspecified urinary incontinence
2.8
6.3
31
114
A04AA02
ATC
granisetron; systemic, transdermal
0.2
6.3
8
338
F06.0
ICD-10 Finland
Organic hallucinosis
11.1
6.3
11
10
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
3.9
6.3
18
47
F02.01
ICD-10 Finland
Dementia in Pick's disease has other additional symptoms, mainly paranoidism
+∞
6.3
6
*
F060, G310,
ICD-10 Finland
+∞
6.3
6
*
F020, G310,
ICD-10 Finland
+∞
6.3
6
*
85190
ICD-8 Finland
Cerebral laceration and contusion, Late effect
26.9
6.2
8
*
F30.9
ICD-10 Finland
Manic episode, unspecified
26.9
6.2
8
*
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
7.1
6.2
14
20
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
7.1
6.2
14
20
F21, ,
ICPC
6.3
6.2
15
24
N06AB05
ATC
paroxetine; oral
2.3
6.2
44
195
SPAT1294
SPAT
Other function in accordance with health social work nomenclature
2.9
6.1
28
99
P01
ICPC
Feeling anxious/nervous/tense
2.2
6.1
51
241
AXX01
NOMESCO Finland
Memory assessment
7.7
6.1
13
17
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
1.8
6.1
95
560
N05AF05
ATC
zuclopenthixol; systemic
6.8
6.0
14
21

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
142
39
43.51
233.08
1.0
1.0
919.77
773.05
ng/l
1.34
114
22
141
39
43.14
230.96
1.0
1.0
279.11
206.81
ng/l
2.45
120
21
135
133
11.88
123.91
1.2
1.3
2.63
75.79
e6/l
0.92
90
100
135
134
11.79
123.26
1.2
1.4
760.49
1008.50
e6/l
0.10
95
105
97
84
12.91
96.27
6.3
5.4
325.26
359.79
umol/l
1.08
85
75
111
120
10.49
94.84
1.1
1.3
—
—
—
0
0
77
60
14.01
81.22
1.3
1.3
—
—
—
0
0
66
64
11.10
60.38
1.1
1.1
—
—
—
0
0
279
1441
2.39
29.08
1.9
1.8
1165.00
1171.71
nmol/l
0.04
222
1084
496
3498
2.00
21.22
2.6
2.2
93.69
95.27
pmol/l
0.31
280
1811
356
2403
1.83
15.83
1.9
1.8
20.39
20.14
nmol/l
0.12
328
1990
112
2198
0.44
15.38
2.8
3.7
—
—
—
0
0
347
2420
1.73
13.14
3.6
4.4
7.40
7.40
ph
0.80
240
1768
58
216
2.81
11.44
1.2
1.3
—
—
—
0
0
466
3624
1.63
10.96
6.3
6.7
1.21
1.21
mmol/l
1.08
435
3336
248
1658
1.70
10.47
3.0
3.2
2.45
2.47
mmol/l
1.77
211
1482
360
2688
1.59
9.60
2.8
3.7
2.35
2.35
mmol/l
0.47
319
2421
19
37
5.23
9.39
1.0
1.1
120.63
143.52
nmol/l
0.99
19
37
497
4018
1.57
9.23
6.6
7.5
1.22
1.21
mmol/l
3.73
442
3456
332
2452
1.58
9.16
2.7
2.3
719.82
242.56
u/l
0.55
317
2326
337
2500
1.58
9.11
4.0
3.5
—
—
—
0
0
232
1589
1.63
8.68
4.1
4.4
337.17
323.94
ng/l
0.03
201
1358
322
2389
1.56
8.57
4.3
4.6
—
—
—
0
0
438
3513
1.51
7.93
4.1
5.3
35.40
34.82
g/l
1.35
405
3281
202
2825
0.63
7.64
1.9
2.3
—
—
—
0
0
204
2826
0.63
7.31
3.3
4.2
4.20
8.88
mg/mmol
3.98
129
1790
209
1456
1.58
7.11
3.4
3.2
1.68
1.06
e6/l
1.14
94
814
286
2138
1.51
7.05
3.7
3.6
—
0.00
estimate
—
0
11
200
2764
0.64
7.01
2.9
3.5
29.44
47.84
mg/l
2.39
131
1804
196
1350
1.59
6.99
3.4
3.4
5.38
1.96
e6/l
1.01
76
705
212
2878
0.65
6.77
1.9
2.0
1.41
1.31
mmol/l
0.92
189
2324
205
2790
0.65
6.58
2.8
3.5
7.26
7.27
mmol/l
0.01
185
2329
116
714
1.72
6.39
2.8
2.5
32.67
36.21
u/l
0.50
100
600
228
1671
1.50
6.03
5.3
4.5
1.02
1.02
kg/l
0.13
151
1137
239
1772
1.49
5.96
4.5
4.1
—
0.12
—
0
26
582
6463
0.68
5.88
4.3
5.5
1.43
1.45
mmol/l
0.51
528
5858
557
6219
0.70
5.61
3.7
4.7
1.29
1.29
mmol/l
0.07
493
5584
577
6402
0.69
5.60
6.3
7.4
39.24
40.26
mmol/mol
2.17
538
5900
256
1947
1.45
5.55
4.3
4.3
87.53
85.02
%
0.86
245
1918
291
2294
1.41
5.09
3.8
3.6
0.30
0.53
e6/l
1.95
199
1727
10
13
7.77
4.86
1.7
2.2
27.42
17.97
umol/l
—
10
13
609
6636
0.71
4.64
5.5
6.5
2.61
2.56
mmol/l
0.65
558
6032
115
769
1.57
4.57
6.4
8.3
—
—
—
0
0
228
2889
0.71
4.55
2.9
3.3
847.03
1684.41
ng/l
10.00
194
2539
16
49
3.31
4.48
1.2
1.1
—
—
—
0
0
69
1118
0.58
4.48
1.2
1.3
4.26
13.01
u/ml
1.67
19
390
37
720
0.49
4.44
1.2
1.4
—
—
—
0
0
75
1186
0.60
4.42
1.3
1.3
29.69
34.93
iu/ml
0.13
22
386
596
6503
0.72
4.41
4.4
5.6
4.51
4.47
mmol/l
0.44
540
5946
17
57
3.02
4.14
1.3
1.1
—
—
—
0
0
43
223
1.98
4.13
2.7
3.6
1.35
1.70
index
0.22
20
122
44
231
1.95
4.09
2.0
1.6
0.22
0.31
mg/l
0.62
21
99
17
59
2.92
3.91
1.3
1.1
—
—
—
0
0
360
3032
1.32
3.89
4.1
3.9
6.37
6.28
ph
0.68
174
1663
172
1291
1.42
3.86
1.5
2.0
29.44
29.57
s
0.13
164
1261
37
687
0.52
3.86
4.3
4.8
0.13
0.14
%
—
8
187
36
671
0.52
3.80
3.5
4.5
0.30
0.12
%
—
10
194
6
5
12.07
3.77
1.0
1.0
—
—
—
0
0
6
5
12.07
3.77
1.0
1.0
8.90
8.23
mg/g
—
6
5
318
2647
1.32
3.68
3.8
3.7
59.57
99.13
e6/l
0.60
226
2065
37
675
0.53
3.65
3.9
4.4
1.18
0.57
%
0.55
11
218
57
338
1.74
3.64
2.5
3.5
4.22
4.41
pmol/l
0.67
45
303
16
58
2.79
3.43
1.3
1.1
—
—
—
0
0
12
32
3.79
3.40
1.1
1.2
—
—
—
0
0
342
2903
1.30
3.36
4.6
4.4
78.07
140.19
e6/l
1.15
228
2139
212
1685
1.34
3.32
1.7
1.8
449.20
20296740.94
pmol/l
1.18
177
1350
56
887
0.61
3.32
1.1
1.3
—
—
—
0
0
16
60
2.70
3.24
1.3
1.1
—
—
—
0
0
16
60
2.70
3.24
1.3
1.1
—
—
—
0
0
10
290
0.34
3.21
1.5
1.9
3.40
3.40
mmol/l
—
10
221
42
708
0.57
3.17
3.9
4.4
1.56
0.91
%
0.84
16
231
568
5172
1.30
3.13
31.1
25.5
331.56
331.16
g/l
0.44
562
5139
12
35
3.46
3.11
1.8
1.5
152.57
107.50
umol/l
—
7
22
33
175
1.92
3.04
2.6
3.0
32.22
34.23
umol/l
0.19
27
155
108
788
1.42
2.84
6.8
7.2
1.29
1.35
mmol/l
0.41
103
779
63
931
0.65
2.77
2.9
4.4
15.95
30.21
ug/l
0.60
56
775
157
1976
0.75
2.74
4.2
3.9
0.05
0.04
estimate
0.04
41
651
70
1006
0.67
2.68
1.3
1.4
—
—
—
0
0
43
676
0.62
2.50
1.6
1.5
—
—
—
0
0
303
3474
0.80
2.46
2.7
2.9
—
—
estimate
—
0
0
14
57
2.48
2.46
1.3
1.2
244.00
349.65
nmol/l
1.50
14
48
163
2012
0.77
2.45
2.4
3.0
340.13
359.39
umol/l
1.41
130
1727
5
161
0.31
2.42
3.6
2.8
47.80
59.29
%
—
5
161
10
33
3.05
2.36
1.1
1.4
28.60
29.89
umol/l
—
10
28
113
860
1.36
2.34
2.8
3.6
2.81
1.95
mmol/l
1.84
101
731
134
1048
1.33
2.32
7.5
7.2
1.05
0.95
mmol/l
0.09
112
864
134
1048
1.33
2.32
7.6
7.3
7.42
7.41
ph
0.70
73
598
97
721
1.39
2.32
2.8
3.2
120.98
259.90
ng/l
7.45
92
663
65
918
0.68
2.29
1.2
1.3
595.56
488.07
titre
—
9
223
615
6519
0.80
2.29
5.2
5.8
6.05
6.08
mmol/l
0.17
576
5859
13
284
0.45
2.25
1.2
1.4
—
—
—
0
0
277
3183
0.81
2.24
9.3
12.7
0.00
0.00
e9/l
0.16
201
2579
554
5128
1.23
2.19
4.8
4.3
14.70
15.08
pmol/l
2.82
517
4601
150
1844
0.77
2.16
1.2
1.3
—
—
—
0
0
11
42
2.64
2.14
1.8
1.3
—
—
—
0
0
81
593
1.40
2.13
9.6
8.9
1.29
1.30
%
0.03
81
588
39
601
0.63
2.11
1.9
1.5
—
—
—
0
0
37
575
0.63
2.08
3.9
2.8
6.17
6.06
ph
0.34
27
400
86
639
1.38
2.08
3.2
3.9
77.85
94.29
ng/l
1.45
71
554
39
598
0.64
2.07
5.0
4.2
—
—
—
0
0
8
194
0.41
2.06
2.8
3.5
789.29
1930.90
u/ml
—
8
182
10
233
0.42
2.06
2.2
5.3
—
—
—
0
0
132
1052
1.30
2.01
7.7
7.3
5.03
5.12
kpa
0.39
127
1018
132
1053
1.30
1.99
7.7
7.3
11.72
11.83
kpa
0.08
127
1019
66
905
0.71
1.99
3.6
3.1
9.68
4.74
e9/l
0.86
56
768
46
668
0.67
1.90
3.1
3.9
1.24
1.23
mmol/l
0.85
39
574
24
405
0.58
1.90
1.8
1.4
—
—
—
0
0
10
221
0.45
1.83
1.3
1.6
14391.20
13596.30
e6/l
—
5
161
280
3158
0.83
1.77
3.1
3.1
128.83
152.99
ug/l
1.35
263
2870
79
1032
0.74
1.77
1.4
1.3
—
—
—
0
0
10
217
0.45
1.75
1.6
1.7
—
—
—
0
0
354
3186
1.19
1.73
2.4
2.4
79.00
79.76
nmol/l
0.18
320
2799
0
49
0.00
1.68
0.0
1.9
—
1177.70
—
0
43
7
25
2.81
1.65
1.7
1.8
62.86
49.07
ug/l
—
7
25
120
1462
0.79
1.60
4.1
5.0
—
—
—
0
0
8
175
0.45
1.58
1.9
1.9
39.38
43.32
nmol/l
—
8
164
26
407
0.63
1.56
3.2
4.1
—
—
—
0
0
111
896
1.27
1.56
2.6
3.6
7.39
7.38
ph
0.64
57
530
30
193
1.57
1.53
1.3
1.2
—
—
—
0
0
0
42
0.00
1.53
0.0
1.4
—
63.27
—
0
33
5
125
0.40
1.51
3.4
2.9
3.21
4.53
e9/l
—
5
125
12
230
0.51
1.50
1.8
3.3
1.97
1.57
mmol/l
0.28
12
225
17
293
0.57
1.50
1.2
1.3
—
—
—
0
0
526
4932
1.17
1.49
5.5
5.0
—
3.06
—
0
9
188
1621
1.21
1.45
2.6
3.3
543.15
528.20
mosm/kgh2o
0.41
164
1416
22
351
0.62
1.44
1.2
1.3
—
—
—
0
0
22
351
0.62
1.44
2.8
3.5
105.14
11650.80
u/ml
0.85
14
301
41
573
0.70
1.43
3.1
4.0
7.41
7.42
ph
0.30
35
486
146
1719
0.82
1.42
2.9
3.5
0.97
0.80
ug/l
0.44
112
1188
75
942
0.78
1.30
1.2
1.5
—
—
—
0
0
16
91
1.77
1.29
1.3
1.4
280.64
273.84
mosm/kgh2o
0.45
11
67
10
192
0.52
1.29
1.9
3.5
6.61
7.49
mmol/l
—
10
187
248
2214
1.17
1.28
5.8
6.6
—
—
—
0
0
27
178
1.53
1.27
1.5
1.3
65.50
60.85
mmol/l
0.21
22
150
24
154
1.57
1.27
1.1
1.2
—
—
—
0
0
58
748
0.76
1.23
1.9
2.2
0.00
0.02
estimate
—
6
133
7
144
0.48
1.21
1.0
1.2
—
—
—
0
0
13
225
0.57
1.20
1.0
1.6
1.26
1.19
g/l
0.38
13
215
6
130
0.46
1.16
1.2
1.8
3.32
1.62
mmol/l
—
6
125
83
673
1.26
1.16
1.8
2.1
379.10
381.49
nmol/l
0.03
73
624
0
34
0.00
1.16
0.0
3.1
—
—
—
0
0
0
34
0.00
1.16
0.0
2.0
—
693.96
—
0
27
0
36
0.00
1.14
0.0
1.4
—
1.20
—
0
30
13
221
0.58
1.13
1.0
1.6
0.25
0.23
g/l
0.36
13
212
19
292
0.64
1.11
2.5
3.3
96.50
314.37
mg/l
—
8
118
479
4518
1.14
1.09
5.9
5.2
6.85
6.78
mmol/l
0.31
456
4337
156
1359
1.18
1.08
2.5
3.2
0.83
0.82
mmol/l
0.85
144
1282
214
1915
1.16
1.06
3.2
3.5
0.00
0.04
—
5
57
15
90
1.68
1.04
1.5
1.5
10.83
10.19
%
0.20
15
90
109
1279
0.83
1.04
2.2
2.6
21.41
22.19
%
0.23
100
1200
5
106
0.47
1.01
1.2
1.7
—
—
—
0
0
0
29
0.00
0.98
0.0
3.4
—
—
—
0
0
0
29
0.00
0.98
0.0
1.1
—
—
—
0
0
0
29
0.00
0.98
0.0
1.1
—
—
—
0
0
0
29
0.00
0.98
0.0
1.1
—
—
—
0
0
0
29
0.00
0.98
0.0
1.1
—
14.44
—
0
22
673
6928
0.86
0.97
11.5
13.5
24.07
25.01
u/l
0.90
647
6693
44
564
0.77
0.94
2.2
2.4
11.24
13.05
nmol/l
0.77
33
495
34
252
1.36
0.93
1.4
2.0
20.50
21.38
s
0.50
28
236
320
3436
0.89
0.91
5.0
6.3
0.65
0.67
%
0.34
300
3192
5
102
0.49
0.90
1.0
1.5
—
—
—
0
0
86
724
1.21
0.89
3.2
2.6
7.84
6.85
ug/l
0.15
71
641
13
79
1.66
0.88
1.2
1.3
—
—
nmol/l
—
0
0
324
3469
0.89
0.86
4.9
6.3
25.66
26.14
%
0.32
306
3260
208
1885
1.14
0.86
2.8
2.8
6.19
4.67
e6/l
0.48
190
1724
405
3820
1.12
0.85
4.7
4.4
0.06
1.91
estimate
0.48
50
849
6
31
1.94
0.84
1.0
1.5
154.17
174.92
mmol/24h
—
6
31
8
139
0.57
0.83
1.3
1.4
1.53
0.84
nmol/l
—
8
111
13
202
0.64
0.83
1.1
1.2
—
—
—
0
0
110
1261
0.85
0.82
1.4
1.5
2.22
2.64
g/l
1.50
54
739
10
165
0.60
0.82
1.3
1.2
9.35
34.95
u/l
—
10
145
320
3417
0.90
0.80
5.0
6.2
59.95
58.28
%
1.61
305
3233
0
24
0.00
0.79
0.0
1.1
—
5.14
—
0
15
9
151
0.59
0.79
1.8
1.6
—
—
—
0
0
11
175
0.62
0.79
1.0
1.3
—
—
—
0
0
322
3434
0.90
0.78
5.0
6.4
8.71
9.16
%
2.09
300
3186
0
26
0.00
0.78
0.0
1.3
—
—
—
0
0
7
126
0.55
0.77
1.4
1.7
—
—
—
0
0
0
28
0.00
0.76
0.0
1.4
—
—
—
0
0
0
28
0.00
0.76
0.0
1.3
—
37.09
—
0
18
121
1363
0.87
0.73
2.2
2.6
2.18
2.26
g/l
0.89
105
1265
12
76
1.59
0.72
3.6
3.6
13.83
11.40
index
—
6
47
130
1455
0.87
0.72
2.3
2.7
11.76
12.31
umol/l
0.44
118
1362
323
3430
0.91
0.71
4.8
6.3
2.71
2.88
%
0.68
301
3181
690
7054
0.88
0.70
31.8
29.2
6.99
6.84
e9/l
0.88
668
6866
690
7054
0.88
0.70
32.0
29.4
131.15
133.02
g/l
2.67
681
6960
13
193
0.67
0.70
2.5
3.0
87.48
89.11
%
0.30
13
188
690
7053
0.88
0.70
31.8
29.1
4.34
4.41
e12/l
3.07
667
6865
690
7053
0.88
0.70
31.7
29.1
91.82
91.79
fl
0.05
681
6956
690
7053
0.88
0.70
31.7
29.0
30.54
30.45
pg
0.67
681
6956
690
7053
0.88
0.70
32.5
29.7
39.36
39.73
%
1.19
681
6950
690
7052
0.89
0.69
31.8
29.2
242.71
241.75
e9/l
0.15
670
6891
7
121
0.58
0.67
2.4
1.3
—
—
—
0
0
57
479
1.20
0.64
1.2
1.2
—
—
—
0
0
6
103
0.58
0.62
1.3
2.7
—
1.18
—
0
60
11
71
1.56
0.62
1.1
1.2
—
—
—
0
0
6
105
0.57
0.62
1.0
1.1
—
—
—
0
0
54
639
0.83
0.61
1.6
1.5
—
—
—
0
0
226
2425
0.91
0.61
2.7
2.6
51.31
97.30
u/l
0.78
213
2230
0
20
0.00
0.60
0.0
1.9
—
0.00
—
0
20
250
2343
1.09
0.57
3.0
3.3
33.69
33.56
u/l
0.01
234
2204
395
3779
1.08
0.56
4.7
4.3
0.00
0.00
estimate
-0.00
48
824
5
90
0.55
0.56
1.0
1.1
—
—
—
0
0
573
5572
1.09
0.53
6.8
8.7
78.48
81.95
u/l
0.89
543
5243
10
66
1.52
0.52
1.2
1.1
20.00
34.92
mmol/l
—
5
61
6
96
0.62
0.52
1.2
2.2
—
—
—
0
0
364
3800
0.93
0.51
5.6
6.2
0.20
0.20
e9/l
0.02
294
3261
272
2872
0.92
0.51
5.2
6.3
2.90
3.37
ug/l
0.27
235
2561
354
3697
0.93
0.50
5.0
6.1
0.04
0.04
e9/l
0.17
278
3110
630
6160
1.09
0.49
6.3
5.4
2.04
2.04
mu/l
0.00
587
5555
353
3683
0.93
0.48
5.0
6.1
0.60
0.61
e9/l
0.18
276
3092
109
1197
0.90
0.47
1.9
2.0
—
—
—
0
0
82
732
1.13
0.47
1.2
1.5
—
—
—
0
0
401
3859
1.07
0.47
4.7
4.4
0.06
0.39
estimate
0.40
48
791
10
142
0.70
0.46
1.0
1.5
29.76
30.36
g/l
—
10
129
23
287
0.80
0.46
1.1
1.2
—
—
—
0
0
435
4201
1.07
0.46
3.9
3.4
46.55
56.58
u/l
1.45
408
3872
38
449
0.84
0.46
1.3
1.3
—
—
—
0
0
11
153
0.72
0.46
1.9
1.7
—
—
—
0
0
65
735
0.87
0.45
1.8
2.2
167.66
147.40
ug/g
0.24
51
584
207
2199
0.92
0.45
5.4
4.4
0.00
0.01
estimate
0.78
40
753
45
386
1.18
0.44
2.6
2.1
—
—
—
0
0
180
1917
0.92
0.42
2.3
2.5
—
—
—
0
0
16
206
0.77
0.42
1.6
2.6
130.86
84.82
ug/min
—
9
119
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
690
7005
0.92
0.40
27.7
26.1
76.94
83.23
umol/l
4.25
678
6912
0
17
0.00
0.40
0.0
1.1
—
0.20
—
0
7
0
18
0.00
0.40
0.0
1.4
—
32.67
—
0
18
28
335
0.83
0.40
1.0
1.5
—
18.02
—
0
5
7
103
0.68
0.39
1.0
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.7
—
29.11
—
0
13
0
19
0.00
0.39
0.0
1.7
—
11.00
—
0
11
224
2128
1.07
0.37
2.5
2.3
2.77
2.99
mg/l
0.49
196
1795
361
3737
0.94
0.37
5.1
6.2
1.90
1.87
e9/l
0.06
291
3230
670
6594
1.08
0.37
21.6
19.2
31.27
26.85
mg/l
2.48
589
5572
35
300
1.17
0.36
8.0
3.4
1.55
1.39
mmol/l
0.48
35
293
5
79
0.63
0.35
1.0
1.1
—
—
—
0
0
38
329
1.16
0.35
1.9
2.8
10.66
10.61
g/l
0.02
29
295
298
3096
0.94
0.34
4.6
4.4
25.50
83.44
ng/l
1.58
237
2467
54
604
0.89
0.34
1.5
1.5
—
—
—
0
0
380
3917
0.95
0.33
11.5
18.3
1.27
1.33
inr
1.45
327
3302
6
47
1.28
0.32
4.8
3.7
0.83
0.83
index
—
6
47
34
389
0.87
0.31
2.5
2.9
—
—
—
0
0
8
109
0.73
0.29
1.0
1.0
—
—
—
0
0
77
833
0.92
0.28
1.6
2.7
72.77
68.42
e9/l
0.41
53
634
660
6685
0.94
0.28
17.4
17.4
—
—
—
0
0
23
197
1.17
0.26
1.1
1.1
—
—
—
0
0
24
207
1.16
0.25
1.9
2.4
131.88
126.17
g/l
0.36
17
161
6
81
0.74
0.24
1.2
2.3
561.67
1072.14
mg
—
6
81
24
208
1.16
0.24
16.8
12.4
—
—
—
0
0
27
307
0.88
0.24
2.1
3.7
1.50
2.53
ratio
1.66
14
185
5
40
1.25
0.22
1.0
1.0
—
—
—
0
0
242
2497
0.96
0.22
2.4
2.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
20.17
—
0
6
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
37.27
—
0
11
0
12
0.00
0.21
0.0
2.0
—
2.13
—
0
12
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
3.9
—
—
—
0
0
404
4121
0.96
0.21
8.0
9.7
4.61
4.19
e9/l
1.71
331
3551
0
13
0.00
0.21
0.0
5.5
—
8.03
—
0
13
27
240
1.13
0.20
1.1
1.5
252.89
274.96
ug/g
0.31
18
146
0
14
0.00
0.20
0.0
3.0
—
5579.00
—
0
14
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
4.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
111
1057
1.06
0.19
1.7
2.7
1.81
1.81
%
0.01
100
956
12
99
1.22
0.19
2.8
1.7
432.17
302.51
mu/l
0.30
12
92
687
6930
0.95
0.19
27.1
23.7
3.95
4.00
mmol/l
6.30
675
6779
10
122
0.82
0.19
1.3
1.1
—
—
—
0
0
5
69
0.72
0.17
1.2
1.2
—
—
—
0
0
687
6921
0.96
0.15
27.3
23.5
139.76
139.59
mmol/l
0.84
675
6779
31
338
0.91
0.15
2.4
4.0
25.81
59.07
mg/l
2.07
25
293
31
338
0.91
0.15
2.3
3.9
49.06
71.68
mg/l
0.56
25
291
136
1402
0.96
0.13
1.3
1.3
1.23
1.51
u/ml
0.15
26
363
11
127
0.86
0.12
1.4
2.3
31.00
32.27
pg
0.26
11
127
38
356
1.07
0.12
1.3
1.2
—
—
—
0
0
82
789
1.04
0.11
3.9
7.0
9.65
11.19
mmol/l
0.99
73
757
17
153
1.11
0.11
1.6
1.8
7.90
5.04
iu/l
—
6
62
278
2824
0.98
0.10
5.0
4.4
0.03
0.02
estimate
0.08
40
679
411
4067
1.02
0.09
4.8
6.8
11.81
12.05
umol/l
0.12
386
3883
259
2553
1.02
0.08
4.5
6.0
—
—
—
0
0
5
65
0.77
0.08
2.0
1.7
7.06
7.95
mmol/l
—
5
65
20
186
1.08
0.07
3.0
3.9
—
—
—
0
0
14
153
0.91
0.07
1.0
1.1
—
—
—
0
0
7
84
0.83
0.07
1.0
1.2
—
—
—
0
0
38
396
0.96
0.06
3.6
3.4
25.93
25.16
mmol/l
0.70
38
383
109
1110
0.98
0.05
4.1
5.8
0.98
1.04
mmol/l
2.03
99
1028
45
435
1.04
0.05
2.2
2.5
—
—
—
0
0
91
893
1.02
0.04
1.8
1.8
—
—
—
0
0
21
221
0.95
0.04
1.0
1.1
—
—
—
0
0
63
641
0.98
0.02
1.9
2.8
—
—
—
0
0
34
348
0.98
0.01
1.1
1.1
50.27
121.22
u/ml
—
9
124
88
872
1.01
0.01
2.4
2.9
8.43
8.56
umol/l
0.02
79
782
78
774
1.01
0.00
2.0
3.1
66.43
66.11
g/l
0.15
66
714
78
786
0.99
0.00
3.5
4.6
7.39
7.35
ph
0.87
60
570
10
104
0.96
0.00
1.1
1.0
—
—
—
0
0
10
98
1.02
0.00
1.4
1.4
—
—
—
0
0
10
98
1.02
0.00
1.4
1.4
—
—
—
0
0
10
98
1.02
0.00
1.4
1.4
—
—
—
0
0
10
98
1.02
0.00
1.4
1.4
—
—
—
0
0
161
1608
1.00
0.00
1.7
1.7
1.76
1.50
mg/l
0.27
124
1273
16
161
0.99
0.00
3.3
4.8
2.85
2.70
mmol/l
0.07
11
113
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
64.00
—
0
7
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.2
—
0.34
—
0
5
6
60
1.00
-0.00
1.0
1.1
117.33
98.15
pmol/l
—
6
60
0
8
0.00
-0.00
0.0
1.1
—
31.60
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
0.59
—
0
8
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
1.8
1.7
18.78
15.87
%
—
5
58
6
62
0.97
-0.00
1.8
2.3
—
—
—
0
0
7
69
1.01
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
79
1.01
-0.00
2.1
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
79
1.01
-0.00
1.0
1.3
18.76
27.04
ng/l
—
8
79
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
191.60
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint G6_ATROPHCIRCUM and mortality.

Females

Parameter HR [95% CI] p-value
G6_ATROPHCIRCUM 3.807 [3.24, 4.47] < 0.001
Birth year 0.996 [0.99, 1.0] 0.335

During the follow-up period (1.1.1998 — 31.12.2019), 1496 out of 2867 females with G6_ATROPHCIRCUM died.

Males

Parameter HR [95% CI] p-value
G6_ATROPHCIRCUM 3.818 [3.16, 4.61] < 0.001
Birth year 0.991 [0.98, 1.0] 0.052

During the follow-up period (1.1.1998 — 31.12.2019), 1262 out of 2230 males with G6_ATROPHCIRCUM died.

Mortality risk

Mortality risk for people of age

years, who have G6_ATROPHCIRCUM.

N-year risk Females Males
1 0.352% 0.706%
5 2.162% 4.74%
10 5.576% 11.668%
15 10.637% 21.832%
20 18.658% 34.354%

Relationships between endpoints

↥

Index endpoint: G6_ATROPHCIRCUM – Circumscribed brain atrophy

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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