Other and unspecified haemorrhagic conditions

D3_HAEMORRHAGICNAS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D69.9
  • Hospital discharge: ICD-9 287[8-9]
  • Hospital discharge: ICD-8 2879
  • Hospital discharge: excluded ICD-8 28790
  • Cause of death: ICD-10 D69.9
  • Cause of death: ICD-9 287[8-9]
  • Cause of death: ICD-8 2879
  • Cause of death: excluded ICD-8 28790

2 out of 7 registries used, show all original rules.

689

4. Check minimum number of events

None

689

5. Include endpoints

None

689

6. Filter based on genotype QC (FinnGen only)

599

Control definitions (FinnGen only)

Control exclude
D3_COAGDEF_PURPUR_HAEMORRHAGIC

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
D69
Name in latin
Status haemorrhagicus non specificatus

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4553 2524 1979
Only index persons 3723 2126 1597
Unadjusted period prevalence (%)
Whole population 0.06 0.07 0.06
Only index persons 0.07 0.08 0.06
Median age at first event (years)
Whole population 55.34 53.94 56.82
Only index persons 52.24 50.26 54.86

-FinnGen-

Key figures

All Female Male
Number of individuals 599 353 246
Unadjusted period prevalence (%) 0.12 0.13 0.11
Median age at first event (years) 56.19 50.77 63.98

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
624
Matched controls
6240
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
8671.6
307.7
536
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
105.0
202.9
105
12
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
63.6
60
*
28799
ICD-8 Finland
Purpura and other haemorrhagic conditions, Other and unspecified
+∞
56.1
53
*
D69.0
ICD-10 Finland
Allergic purpura
435.1
41.6
41
*
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
36.8
35
*
B02AA02
ATC
tranexamic acid; systemic
3.3
30.1
139
504
WW500
NOMESCO Finland
Blood transfusion
5.9
29.7
56
103
XW000
NOMESCO Finland
Bone marrow biopsy
6.1
29.6
54
96
D68.9
ICD-10 Finland
Coagulation defect, unspecified
+∞
28.3
27
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.2
23.7
110
396
R50.9
ICD-10 Finland
Fever, unspecified
2.7
22.3
140
594
R4110
NOMESCO Finland
Physiotherapy
2.4
21.9
216
1134
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.3
21.8
89
296
H02AB07
ATC
prednisone; oral
2.9
21.7
122
488
ZX120
NOMESCO Finland
Intravenous
3.2
21.4
92
316
ZXD05
NOMESCO Finland
Urgent procedure
2.3
21.3
231
1261
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
21.0
340
2184
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
20.9
20
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.3
20.9
89
303
L04AX01
ATC
azathioprine; systemic
4.9
20.2
46
100
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
19.9
173
855
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.9
19.4
61
170
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
19.1
100
383
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.6
19.0
133
592
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
19.0
218
1208
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
18.8
119
504
L04AA06
ATC
mycophenolic acid; systemic
7.3
18.8
28
40
ZXE00
NOMESCO Finland
One hour or less
2.1
18.3
276
1698
C03CA01
ATC
furosemide; systemic
2.2
17.9
228
1312
ZXE20
NOMESCO Finland
More than three and less than five hours
2.7
17.5
111
470
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
16.7
16
*
H02AB06
ATC
prednisolone; systemic
2.0
16.4
323
2164
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.3
16.1
145
720
Z3231
NOMESCO Finland
Registered nurse
2.1
15.8
201
1145
D69.1
ICD-10 Finland
Qualitative platelet defects
+∞
15.7
15
*
N02AX02
ATC
tramadol; systemic, rectal
2.0
15.7
294
1928
D68.8
ICD-10 Finland
Other specified coagulation defects
39.1
15.5
19
5
ZXE10
NOMESCO Finland
More than one and less than three hours
2.0
15.2
247
1536
2879X
ICD-9 Finland
Purpura and other haemorrhagic conditions, Unspecified haemorrhagic conditions
+∞
14.6
14
*
A02BC02
ATC
pantoprazole; systemic
2.0
14.6
442
3384
R23.3
ICD-10 Finland
Spontaneous ecchymoses
5.6
14.6
28
52
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
37.0
14.5
18
5
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.3
14.4
58
190
Z3226
NOMESCO Finland
Physiotherapist
2.2
14.2
138
705
Z2221
NOMESCO Finland
Medical doctor
2.0
14.0
195
1141
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
14.0
254
1631
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.1
13.8
156
845
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
13.6
230
1437
TK800
NOMESCO Finland
Hemodialysis
5.6
13.6
26
48
28798
ICD-8 Finland
Purpura and other haemorrhagic conditions, Purpura et status haemorrhagicus alius
+∞
13.6
13
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.4
13.1
26
50
B01AA03
ATC
warfarin; systemic
2.2
12.8
135
709
I50.9
ICD-10 Finland
Heart failure, unspecified
2.3
12.8
116
574
D07AB08
ATC
desonide; topical
2.5
12.8
87
379
28719
ICD-8 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia NUD
+∞
12.5
12
*
C03DA01
ATC
spironolactone; oral
2.4
12.4
93
423
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.9
12.3
59
214
UJF32
NOMESCO Finland
Coloscopy
2.0
12.3
174
1017
N18.8
ICD-10 Finland
Other chronic renal failure
5.3
12.3
25
49
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
12.2
174
1020
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.6
12.1
41
120
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.1
12.1
33
83
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.0
12.0
26
54
JN3AD
NOMESCO Finland
Abdominal CT examination
2.3
11.9
97
457
D69.8
ICD-10 Finland
Other specified haemorrhagic conditions
47.6
11.9
14
*
L04AD01
ATC
ciclosporin; systemic
6.0
11.9
21
36
126
Kela drug reimbursment
Chronic coagulation defects
+∞
11.5
11
*
B01AB05
ATC
enoxaparin; parenteral
1.9
11.5
205
1291
A46
ICD-10 Finland
Erysipelas
2.2
11.5
107
534
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
11.5
248
1658
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.1
11.3
31
78
C07AB07
ATC
bisoprolol; oral
1.8
11.3
313
2249
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
11.3
85
387
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.6
11.0
36
103
H02AB04
ATC
methylprednisolone; systemic
2.2
11.0
100
493
M05BA04
ATC
alendronic acid; oral
2.6
11.0
67
276
J01MA12
ATC
levofloxacin; systemic
2.0
10.9
129
704
J01FF01
ATC
clindamycin; systemic
1.9
10.5
177
1089
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
10.3
182
1136
WX002
NOMESCO Finland
Sedation and analgesia
2.0
10.2
126
697
M04AA01
ATC
allopurinol; systemic
2.2
10.2
90
438
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.1
10.2
43
145
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.3
10.2
39
124
K92.1
ICD-10 Finland
Melaena
2.9
10.2
48
173
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.8
10.0
53
203
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
10.0
107
563
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.0
10.0
130
734
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.5
9.8
64
272
AA1AD
NOMESCO Finland
CT of head and brain
1.8
9.8
190
1219
KA1AE
NOMESCO Finland
Kidney ultrasound examination
4.3
9.7
25
60
D69
ICD-10 Finland
Purpura and other haemorrhagic conditions
55.9
9.7
11
*
P01AB01
ATC
metronidazole; oral, rectal
1.7
9.6
255
1786
WZC00
NOMESCO Finland
Treatment plan or consultation
1.7
9.4
233
1598
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
9.4
9
*
2873A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[PURPURA THROMBOCYTOPENICA IDIOPATHICA (ITP)]
+∞
9.4
9
*
R06AE07
ATC
cetirizine; oral
1.7
9.4
266
1894
R04.0
ICD-10 Finland
Epistaxis
2.5
9.4
60
253
J01DB01
ATC
cefalexin; oral
2.0
9.3
513
4386
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.6
9.3
56
229
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.7
9.1
29
82
L95.8
ICD-10 Finland
Other vasculitis limited to skin
37.3
9.0
11
*
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
37.3
9.0
11
*
6BA02, ,
NOMESCO Finland
37.3
9.0
11
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
9.0
144
868
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
8.9
183
1188
B03BA03
ATC
hydroxocobalamin; parenteral
2.8
8.9
44
163
L04AA01
ATC
[U] ciclosporin
9.7
8.8
17
18
Z2446
NOMESCO Finland
Social worker
2.6
8.7
53
218
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.8
8.7
43
159
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.6
8.6
51
207
E0000UV, ,
ATC
1.7
8.5
263
1903
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
8.5
78
386
D69.5
ICD-10 Finland
Secondary thrombocytopenia
91.2
8.4
9
*
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.7
8.4
185
1222
I34.1
ICD-10 Finland
Mitral (valve) prolapse
3.7
8.4
26
72
D68.3
ICD-10 Finland
Haemorrhagic disorder due to circulating anticoagulants
+∞
8.3
8
*
R06.0
ICD-10 Finland
Dyspnoea
1.7
8.2
181
1194
S20.2
ICD-10 Finland
Contusion of thorax
2.8
8.2
42
158
JMA10
NOMESCO Finland
Transabdominal total splenectomy
14.7
8.2
13
9
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
8.3
8.1
17
21
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
4.4
8.0
20
47
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
8.0
125
746
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
7.9
131
794
127
Kela drug reimbursment
Transplant complication
6.7
7.9
19
29
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.9
7.7
36
129
A11CC03
ATC
alfacalcidol; systemic
3.8
7.7
23
62
R31
ICD-10 Finland
Unspecified haematuria
2.1
7.6
74
374
J01DA01
ATC
[U] cefalexin
1.6
7.5
371
2980
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.3
7.5
59
274
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
2.8
7.4
37
138
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.1
7.3
31
105
2878X
ICD-9 Finland
Purpura and other haemorrhagic conditions, Other specified haemorrhagic conditions
+∞
7.3
7
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
16.0
7.2
11
7
D70.89
ICD-10 Finland
Neutropenic splenomegaly
7.4
7.2
16
22
D70.82
ICD-10 Finland
Drug-induced neutropenia
4.6
7.2
17
38
N03AX16
ATC
[U] pregabalin
1.7
7.2
138
872
205
Kela drug reimbursment
Chronic hypertension
1.7
7.1
157
1032
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
8.9
7.1
14
16
A41.9
ICD-10 Finland
Sepsis, unspecified
3.2
7.1
27
86
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.7
7.0
37
142
C08CA01
ATC
amlodipine; oral
1.6
7.0
228
1653
JN4AD
NOMESCO Finland
Body CT examination
2.0
6.9
73
380
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
6.9
84
460
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
6.9
318
2493
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
6.9
68
345
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.8
6.9
33
120
TQW80
NOMESCO Finland
Local dermatologic skincare
3.9
6.9
20
53
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.7
6.8
128
805
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
40.5
6.8
8
*
JN4BD
NOMESCO Finland
Extensive body CT
2.1
6.8
67
341
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
7.3
6.7
15
21
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.0
6.7
73
385
XLA10, ,
NOMESCO Finland
2.9
6.6
30
106
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
6.6
74
394
R1240
NOMESCO Finland
Social assessment of need and possibilities of rehabilitation
8.8
6.6
13
15
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.7
6.6
35
135
ZXA05
NOMESCO Finland
Left side
1.7
6.5
146
960
J02AC01
ATC
fluconazole; systemic
1.6
6.5
232
1712
J47
ICD-10 Finland
Bronchiectasis
4.0
6.5
18
46
B01AB10
ATC
tinzaparin; parenteral
2.0
6.4
73
390
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
70.5
6.4
7
*
UKC02
NOMESCO Finland
Cystoscopy
1.8
6.4
98
578
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
6.4
427
3612
WW200
NOMESCO Finland
Immunization
3.5
6.3
21
61
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.3
6.3
23
71
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.1
6.3
62
314
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.2
6.3
51
239
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
6.3
145
961
B02BX05
ATC
eltrombopag; oral
+∞
6.3
6
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
6.2
259
1972
N02AA05
ATC
oxycodone; systemic
1.7
6.2
116
726
L03AA02
ATC
filgrastim; parenteral
3.4
6.2
22
67
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.1
6.2
58
289
S97
ICPC
Chronic ulcer skin
2.3
6.2
47
215
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.5
6.1
37
152
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
6.1
116
731
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.0
6.0
66
348

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
217
790
3.68
49.01
4.0
2.2
30.80
29.41
s
2.21
212
771
91
207
4.98
38.28
3.7
2.1
20.11
20.95
s
1.07
84
189
48
74
6.94
30.23
1.6
1.4
—
—
—
0
0
199
882
2.84
30.14
4.3
3.5
0.81
0.82
mmol/l
0.63
190
844
154
611
3.02
28.40
4.1
2.6
1.80
1.74
%
0.26
145
556
194
899
2.68
26.47
3.9
2.6
11.76
12.99
umol/l
1.63
185
838
173
773
2.71
25.23
3.9
2.7
20.67
22.38
%
0.98
167
729
78
225
3.82
23.75
2.0
1.8
1.60
1.46
g/l
0.52
65
205
178
841
2.56
22.91
3.9
2.6
2.27
2.32
g/l
0.59
170
784
438
3067
2.44
22.74
16.2
9.1
4.14
4.10
e9/l
0.14
390
2670
300
1793
2.30
22.65
10.3
5.8
—
—
—
0
0
118
464
2.90
21.67
3.3
2.4
70.50
67.99
e9/l
0.31
85
364
265
1533
2.27
21.30
4.3
3.3
0.58
0.39
e6/l
0.54
206
1109
254
1456
2.26
20.75
4.2
3.2
—
0.00
estimate
—
0
9
405
2809
2.26
20.47
12.0
5.9
1.77
1.91
e9/l
1.23
366
2480
398
2743
2.25
20.41
11.9
5.9
0.61
0.58
e9/l
1.28
355
2352
399
2755
2.24
20.33
11.9
5.9
0.04
0.04
e9/l
0.18
356
2361
74
230
3.52
20.10
2.7
2.1
10.18
5.61
iu/ml
0.67
27
60
65
186
3.78
19.95
1.5
1.3
—
—
—
0
0
406
2852
2.21
19.41
12.0
6.2
0.18
0.19
e9/l
0.89
368
2495
375
2558
2.17
19.26
12.1
6.0
9.12
8.81
%
1.29
361
2411
374
2553
2.16
19.12
12.0
5.9
2.63
2.88
%
1.27
360
2401
380
2610
2.17
19.12
12.2
6.0
26.35
27.72
%
1.61
366
2491
373
2553
2.15
18.81
12.1
6.0
0.68
0.68
%
0.02
360
2397
104
413
2.82
18.60
5.2
2.6
10.58
10.59
g/l
0.00
96
374
246
1447
2.16
18.34
3.7
2.3
3.85
2.94
mg/l
3.49
215
1259
107
436
2.76
18.21
4.0
2.6
65.59
66.67
g/l
0.71
100
406
198
1071
2.24
18.19
3.9
2.9
512.85
537.85
mosm/kgh2o
0.85
183
936
286
1792
2.10
17.97
4.8
3.4
64.01
93.75
e6/l
0.28
227
1359
89
336
2.92
17.43
2.6
1.5
1.31
1.38
g/l
0.10
81
309
152
750
2.36
17.24
1.7
1.4
732.38
465.12
titre
0.71
42
172
245
1469
2.10
17.11
6.2
4.1
—
—
—
0
0
281
1774
2.06
17.05
3.5
2.3
—
—
—
0
0
28
45
6.47
16.87
1.3
1.2
—
—
—
0
0
393
2812
2.07
16.76
9.1
6.1
11.61
11.42
umol/l
0.10
377
2688
343
2353
2.02
16.26
8.3
4.8
35.24
35.76
g/l
1.02
324
2216
310
2060
2.00
16.00
6.1
4.0
97.68
100.96
e6/l
0.03
237
1430
365
2581
2.00
15.62
12.1
5.9
58.69
57.41
%
1.25
357
2469
209
1223
2.07
15.23
3.5
2.8
5.59
6.35
e6/l
0.32
200
1110
88
355
2.72
15.15
3.8
2.2
—
—
—
0
0
174
952
2.15
15.14
3.7
2.9
1.25
0.96
e6/l
0.60
87
487
347
2428
1.97
15.12
18.7
10.8
0.00
0.00
e9/l
0.17
288
1976
165
889
2.16
14.90
3.9
3.1
3.35
2.42
e6/l
0.42
77
425
63
215
3.15
14.66
1.4
1.2
0.27
2.49
u/ml
—
6
11
220
1332
2.01
14.45
3.7
2.8
345.18
342.50
umol/l
0.13
200
1195
368
2652
1.94
14.42
4.7
3.1
169.55
112.78
ug/l
2.45
349
2492
25
43
6.01
14.09
1.2
1.1
—
—
—
0
0
24
40
6.20
13.95
3.4
2.4
840.53
1093.79
e6/l
0.72
19
34
254
1632
1.94
13.92
6.9
4.0
7.40
7.40
ph
0.07
193
1151
125
625
2.25
13.46
2.1
1.7
—
—
—
0
0
340
2435
1.87
13.07
10.4
6.3
1.21
1.21
mmol/l
0.64
326
2243
247
1604
1.89
12.87
8.9
6.2
—
—
—
0
0
343
2471
1.86
12.87
28.1
13.9
1.40
1.25
inr
4.03
298
2053
204
1251
1.94
12.60
3.0
1.7
1.23
1.24
mg/l
0.01
171
974
367
2716
1.85
12.47
11.9
6.8
1.21
1.21
mmol/l
0.81
323
2351
120
616
2.17
12.02
3.9
2.7
6.48
7.37
umol/l
0.33
102
541
212
1346
1.87
11.60
3.7
2.2
—
—
—
0
0
131
708
2.08
11.44
9.8
6.0
1.08
1.06
mmol/l
0.37
125
657
102
500
2.24
11.41
3.0
2.5
36.00
34.24
u/l
0.13
90
413
32
84
3.96
11.06
1.8
1.2
5.33
4.00
u/ml
0.22
12
34
136
754
2.03
11.05
2.8
2.0
—
—
—
0
0
48
165
3.07
11.02
1.4
1.2
53.63
2.87
u/ml
—
6
20
238
1588
1.81
10.96
3.7
3.3
2099.29
1344.99
ng/l
1.14
206
1350
92
439
2.29
10.96
6.3
4.4
0.33
0.14
%
0.80
36
125
48
166
3.05
10.91
1.5
1.3
7.45
5.65
u/ml
—
10
30
90
430
2.28
10.68
6.5
4.3
0.92
0.59
%
0.63
36
130
27
64
4.36
10.65
2.4
1.9
32.93
32.34
pg
0.27
27
64
94
461
2.22
10.47
6.3
4.3
1.22
0.91
%
0.52
38
149
107
559
2.10
10.15
5.8
4.1
1.35
1.88
mmol/l
0.71
93
484
484
4025
1.90
10.12
14.1
7.7
82.09
80.10
u/l
0.40
471
3813
36
110
3.41
10.00
1.7
1.6
—
—
—
0
0
337
2531
1.72
9.95
4.2
2.7
—
—
estimate
—
0
0
24
55
4.50
9.88
1.9
2.3
1.56
1.20
g/24h
0.25
12
35
90
447
2.18
9.70
6.6
4.8
0.06
0.13
%
0.37
33
112
46
167
2.89
9.61
4.5
3.5
39.74
44.55
mg/l
0.14
38
147
46
167
2.89
9.61
4.5
3.5
44.04
89.61
mg/l
0.70
38
147
99
516
2.09
9.42
3.3
2.4
0.21
0.21
g/l
0.32
91
480
43
152
2.96
9.42
4.7
3.2
1.45
2.91
ratio
1.27
24
89
9
0
+∞
9.40
1.4
0.0
38.92
—
s
—
9
0
311
2311
1.69
9.34
4.7
3.6
6.28
6.21
ph
0.48
177
1304
92
469
2.13
9.27
11.4
9.4
—
—
—
0
0
434
3539
1.74
9.11
6.6
4.8
687.00
1941.39
e6/l
—
10
59
18
20
9.23
9.08
3.2
2.7
772.67
600.55
u/ml
0.67
18
20
51
202
2.66
9.05
1.8
1.8
0.46
2.59
ug/l
0.92
45
182
82
404
2.19
9.00
1.8
1.5
—
—
—
0
0
113
636
1.95
8.65
2.1
1.6
—
—
—
0
0
237
1670
1.68
8.49
3.7
2.6
55.88
65.53
u/l
1.50
226
1566
238
1680
1.67
8.46
4.2
3.2
—
—
—
0
0
23
58
4.08
8.40
1.7
1.3
—
—
—
0
0
123
720
1.88
8.35
1.3
1.2
—
—
—
0
0
178
1166
1.74
8.32
2.1
1.4
2.60
2.37
g/l
0.77
113
712
105
588
1.94
8.14
5.6
4.1
7.38
7.38
ph
0.41
66
352
22
55
4.11
8.13
1.8
1.3
0.50
0.43
g/l
0.21
22
39
93
501
2.01
8.05
9.8
7.9
1.44
1.34
mmol/l
0.31
93
493
257
1870
1.64
8.00
4.6
3.3
2.35
2.35
mmol/l
0.05
242
1704
81
416
2.09
7.98
5.8
4.3
88.50
85.74
ng/l
0.11
76
372
20
48
4.27
7.78
1.5
1.0
—
—
—
0
0
37
135
2.85
7.68
1.5
1.2
47.35
41.69
u/ml
—
8
15
189
1291
1.67
7.44
5.2
3.9
—
0.28
—
0
18
32
110
3.01
7.38
4.4
2.6
35.81
33.63
umol/l
0.22
32
98
363
2909
1.59
7.34
5.7
4.0
0.00
0.53
estimate
0.51
82
581
357
2850
1.59
7.34
5.7
4.0
0.00
0.00
estimate
0.50
85
604
63
304
2.19
7.27
3.6
3.0
0.67
0.63
%
0.20
63
304
18
42
4.38
7.26
2.0
2.7
946.33
904.21
mg
0.05
18
42
37
140
2.75
7.19
3.4
3.3
4.57
1.54
index
0.64
21
80
120
731
1.79
7.10
2.7
2.4
138.58
111.03
ug/g
0.34
91
578
115
694
1.81
7.01
1.4
1.3
—
—
—
0
0
358
2881
1.57
6.94
5.7
4.0
0.00
7.95
estimate
1.07
86
618
19
48
4.05
6.93
1.4
1.2
—
—
—
0
0
386
3161
1.58
6.93
8.4
5.0
6.64
6.64
mmol/l
0.02
375
2978
245
1809
1.58
6.93
4.5
3.0
31.02
31.69
u/l
0.09
234
1720
437
3690
1.61
6.84
7.1
4.6
—
3.71
—
0
10
217
1590
1.56
6.19
2.0
1.7
19.47
20.54
nmol/l
0.48
192
1353
304
2404
1.52
6.07
3.4
2.5
75.06
77.03
nmol/l
0.56
290
2169
17
44
3.94
6.02
1.4
1.2
—
—
—
0
0
101
615
1.77
5.94
1.5
1.3
—
—
—
0
0
20
61
3.35
5.62
3.4
2.1
—
—
—
0
0
10
10
10.14
5.54
1.8
2.6
36.00
19.30
%
—
10
10
17
47
3.69
5.51
1.6
2.5
—
—
—
0
0
20
62
3.30
5.49
1.7
1.3
77.20
28.52
ng/l
0.54
20
62
134
901
1.62
5.42
2.2
1.7
—
—
—
0
0
264
2062
1.49
5.41
5.3
3.8
50.65
53.67
ng/l
0.04
190
1446
16
34
4.80
5.33
3.9
2.4
183.80
204.28
e6/l
—
10
29
56
293
2.00
5.26
1.6
1.2
—
—
—
0
0
16
35
4.66
5.20
3.9
2.1
307.00
434.30
e6/l
—
10
27
17
49
3.54
5.20
1.2
1.0
—
—
—
0
0
150
1049
1.57
5.12
4.2
4.0
368.90
367.77
ng/l
0.00
118
798
28
110
2.62
5.11
1.5
1.2
—
—
—
0
0
16
45
3.62
5.07
1.2
1.5
69.17
63.03
%
—
6
35
25
93
2.76
5.06
3.1
3.3
2.01
2.68
mmol/l
0.70
19
55
40
187
2.22
5.02
1.5
1.4
—
—
—
0
0
97
617
1.68
4.86
10.3
7.8
7.41
7.42
ph
0.06
56
354
291
2351
1.45
4.85
2.6
2.1
93.89
95.84
pmol/l
0.30
188
1225
78
468
1.76
4.81
3.8
2.6
0.45
0.57
e6/l
0.23
78
446
169
1231
1.51
4.76
9.2
4.7
—
—
—
0
0
130
896
1.57
4.70
1.9
1.7
1113.03
1169.52
nmol/l
0.29
103
691
27
109
2.54
4.69
1.6
1.4
218.60
241.59
u/ml
0.18
15
58
95
608
1.66
4.64
10.5
7.8
0.30
0.83
mmol/l
0.37
75
508
27
110
2.52
4.61
2.2
3.1
—
—
—
0
0
75
453
1.75
4.53
1.5
1.4
—
—
—
0
0
141
1000
1.53
4.47
1.4
1.4
27.81
31.67
iu/ml
0.19
47
312
64
371
1.81
4.44
1.4
1.2
238.61
260.13
u/ml
0.05
56
340
153
1107
1.51
4.41
3.8
2.8
2.45
2.45
mmol/l
0.03
138
999
44
226
2.02
4.37
2.3
2.3
8283.89
4965.17
u/l
0.33
21
91
49
262
1.94
4.35
2.1
2.4
—
—
—
0
0
16
51
3.19
4.23
1.3
1.5
—
—
—
0
0
21
79
2.72
4.19
1.0
1.1
—
—
—
0
0
415
3633
1.42
4.14
4.8
4.0
—
11224.33
—
0
9
204
1592
1.42
3.91
6.0
4.1
0.00
0.01
estimate
0.74
79
559
80
512
1.65
3.91
11.4
8.5
113.10
121.14
g/l
2.92
80
504
480
4334
1.47
3.91
36.5
19.3
14.08
13.61
%
7.29
475
4297
16
54
3.01
3.87
1.6
1.2
—
—
—
0
0
37
188
2.03
3.81
4.4
3.5
1.09
1.28
mmol/l
1.47
37
181
144
1060
1.47
3.77
2.6
2.0
—
—
—
0
0
6
5
12.10
3.77
1.2
1.0
—
—
—
0
0
24
103
2.38
3.71
2.3
1.6
—
—
—
0
0
54
319
1.76
3.55
3.9
3.7
4.69
4.56
pmol/l
0.25
46
291
9
17
5.35
3.52
1.4
1.8
—
—
—
0
0
126
916
1.47
3.50
1.4
1.3
3.26
10.60
u/ml
2.94
48
371
197
1557
1.39
3.44
4.0
3.1
0.20
0.05
—
5
43
14
47
3.02
3.43
1.2
1.4
—
—
—
0
0
24
107
2.29
3.43
3.1
3.2
0.63
0.87
nmol/l
1.82
19
89
19
76
2.55
3.41
1.1
1.0
—
—
—
0
0
263
2182
1.35
3.38
5.7
3.9
0.07
0.04
estimate
0.26
75
517
22
96
2.34
3.30
2.3
1.5
181.83
148.29
au/ml
—
6
32
66
422
1.63
3.26
6.8
3.3
1.21
1.23
mmol/l
1.01
61
367
16
60
2.71
3.25
3.1
2.5
28.10
61.30
iu/ml
—
6
7
82
554
1.55
3.22
3.5
4.4
24.58
20.41
ug/l
0.09
69
464
555
5217
1.58
3.20
33.6
18.4
139.33
139.66
mmol/l
2.48
544
5114
257
2138
1.34
3.20
2.4
2.1
—
—
—
0
0
15
55
2.77
3.17
1.1
1.4
3160.10
1908.57
e6/l
—
10
37
550
5163
1.55
3.15
31.6
15.5
24.42
23.41
mg/l
0.29
500
4272
555
5223
1.57
3.11
34.5
18.5
3.96
3.97
mmol/l
0.31
544
5111
12
36
3.38
3.03
1.2
1.1
—
—
—
0
0
7
12
5.88
3.02
1.0
1.0
—
—
—
0
0
15
57
2.67
2.98
1.1
1.1
—
—
—
0
0
17
69
2.50
2.98
1.4
1.1
1.44
1.46
g/l
0.07
17
63
20
88
2.31
2.96
1.6
1.4
—
—
—
0
0
94
667
1.48
2.94
1.7
1.4
—
—
—
0
0
17
70
2.47
2.90
1.4
1.4
—
—
—
0
0
17
70
2.47
2.90
1.4
1.4
—
—
—
0
0
17
70
2.47
2.90
1.4
1.4
—
—
—
0
0
17
70
2.47
2.90
1.4
1.4
—
—
—
0
0
39
224
1.79
2.85
1.2
1.3
—
—
—
0
0
26
131
2.03
2.79
1.5
1.5
9755.31
17805.84
e6/l
0.66
16
93
65
432
1.56
2.76
6.2
3.9
—
—
—
0
0
398
3572
1.32
2.73
4.5
3.3
49.89
45.77
u/l
0.67
377
3377
91
652
1.46
2.72
3.3
3.0
5.52
5.75
e9/l
0.05
85
578
60
396
1.57
2.63
2.4
3.3
322.37
229.07
ng/l
0.69
54
370
12
41
2.96
2.63
1.1
1.2
139.75
106.10
pmol/l
0.87
12
41
14
55
2.58
2.63
1.4
1.7
—
—
—
0
0
7
15
4.71
2.60
1.1
1.1
—
—
—
0
0
8
20
4.04
2.57
2.4
3.3
—
—
—
0
0
49
310
1.63
2.56
5.1
4.0
—
—
—
0
0
6
11
5.50
2.55
2.3
1.9
—
—
—
0
0
13
50
2.63
2.54
3.7
4.4
9.61
11.60
%
0.99
13
50
33
188
1.80
2.50
2.5
2.9
—
—
—
0
0
8
21
3.84
2.47
2.0
1.7
—
—
—
0
0
8
21
3.84
2.47
1.4
1.4
—
—
—
0
0
6
12
5.04
2.40
7.3
3.7
—
—
—
0
0
39
237
1.69
2.38
1.7
1.6
0.31
0.29
mg/l
0.07
20
103
8
22
3.67
2.37
1.6
2.0
61.13
102.81
mg/l
—
8
16
7
17
4.15
2.36
2.6
3.6
—
—
—
0
0
16
71
2.29
2.36
1.8
1.3
51.74
77.60
mu/l
0.27
16
66
15
65
2.34
2.33
1.3
1.3
—
—
—
0
0
42
263
1.64
2.30
5.0
3.5
25.02
25.26
mmol/l
0.19
42
256
215
1811
1.29
2.28
4.2
3.4
7.18
7.59
mmol/l
0.70
186
1534
6
13
4.65
2.27
4.0
2.2
—
—
—
0
0
21
107
2.00
2.23
1.1
1.5
56.44
60.22
mmol/l
0.14
16
94
65
455
1.48
2.20
1.3
1.2
—
—
—
0
0
49
323
1.56
2.19
8.0
6.1
23.92
24.62
mmol/l
0.67
49
310
7
19
3.71
2.15
1.4
1.1
—
—
—
0
0
7
19
3.71
2.15
1.4
1.1
—
—
—
0
0
7
19
3.71
2.15
1.4
1.1
—
—
—
0
0
6
14
4.32
2.15
3.5
6.8
23.83
25.16
mmol/l
—
6
14
57
393
1.50
2.09
4.4
3.7
5.07
5.11
kpa
0.12
52
378
158
1292
1.30
2.08
5.2
4.1
1.02
1.02
kg/l
0.34
115
852
12
50
2.43
2.03
1.2
1.4
524331.67
24188.41
e6/l
—
6
27
26
149
1.78
1.97
2.7
2.0
4.86
5.07
iu/l
—
10
60
5
11
4.57
1.94
1.2
1.1
—
—
—
0
0
5
11
4.57
1.94
1.2
1.1
—
—
—
0
0
55
385
1.47
1.89
4.5
3.7
7.42
7.42
ph
0.31
50
314
6
17
3.55
1.84
3.8
3.1
0.64
0.63
mmol/l
—
6
17
6
17
3.55
1.84
1.8
2.1
—
—
—
0
0
54
379
1.47
1.83
1.1
1.3
—
—
—
0
0
5
12
4.19
1.82
1.4
1.1
—
—
—
0
0
12
53
2.29
1.81
4.3
3.3
—
—
—
0
0
12
53
2.29
1.81
3.6
3.0
64.00
57.95
%
0.51
12
47
161
1342
1.27
1.81
1.4
1.3
1.59
1.93
u/ml
0.14
40
372
135
1103
1.29
1.78
1.8
1.7
463.32
17524044.46
pmol/l
0.72
107
953
70
519
1.39
1.78
1.5
1.5
—
—
—
0
0
27
162
1.70
1.77
3.0
1.9
—
—
—
0
0
14
68
2.08
1.71
4.1
3.3
—
—
—
0
0
564
5434
1.39
1.67
37.3
20.1
82.87
77.17
umol/l
1.95
558
5363
6
19
3.18
1.66
2.5
2.2
53.17
72.97
ug/l
—
6
19
14
69
2.05
1.65
1.4
1.2
—
—
—
0
0
5
14
3.59
1.62
1.6
1.4
—
—
—
0
0
19
106
1.82
1.60
5.1
3.0
12.74
8.92
pmol/l
0.61
19
106
187
1607
1.23
1.60
5.0
3.4
0.05
0.06
estimate
0.05
78
493
25
152
1.67
1.59
1.2
1.4
13.35
9.90
u/l
0.62
20
121
66
495
1.37
1.58
2.5
2.1
0.00
0.02
estimate
0.50
13
105
21
122
1.75
1.56
1.6
1.2
—
—
—
0
0
196
1703
1.22
1.50
5.4
4.1
20.44
8.55
mg/mmol
1.27
143
1056
25
155
1.64
1.49
1.9
1.4
294.89
289.27
ug/g
—
9
92
7
28
2.52
1.45
1.3
1.1
37.06
31.99
nmol/l
—
7
22
438
4115
1.22
1.44
5.4
4.3
14.80
14.72
pmol/l
0.29
411
3780
5
16
3.14
1.44
1.0
1.0
—
—
—
0
0
5
16
3.14
1.44
6.8
3.5
55.80
52.38
%
—
5
16
29
189
1.56
1.42
4.0
4.6
207.13
367.54
mg/l
0.69
15
76
16
88
1.84
1.42
1.3
1.2
—
—
—
0
0
9
40
2.27
1.40
1.7
3.4
7.59
8.09
mmol/l
—
9
40
26
166
1.59
1.39
1.2
1.2
—
—
—
0
0
39
273
1.46
1.39
5.2
3.6
—
—
—
0
0
9
41
2.21
1.37
2.8
2.3
1082.22
553.71
ml
—
9
24
6
23
2.62
1.37
1.2
1.1
634.25
117.25
iu/ml
—
6
23
5
17
2.96
1.36
1.0
1.0
—
18.19
—
0
5
191
1671
1.21
1.35
4.7
3.4
116.71
51.33
mg/l
1.01
142
1078
22
138
1.62
1.28
5.9
4.4
—
—
—
0
0
6
26
2.32
1.19
1.0
1.7
—
—
—
0
0
8
38
2.12
1.18
1.8
3.4
15.06
16.78
%
—
8
38
8
38
2.12
1.18
1.1
1.1
—
—
—
0
0
12
64
1.89
1.18
1.2
1.3
0.83
29.85
nmol/l
0.49
12
58
12
64
1.89
1.18
1.2
1.1
—
—
—
0
0
12
65
1.86
1.14
1.4
1.2
—
—
—
0
0
8
41
1.96
1.09
1.6
1.5
—
—
—
0
0
38
279
1.39
1.08
15.1
10.4
14.57
15.78
%
1.79
38
270
51
393
1.32
1.08
1.3
1.2
133.33
160.78
u/ml
0.24
18
158
31
221
1.42
1.05
3.8
3.0
48.10
1483.50
u/ml
1.33
25
194
504
4855
1.20
1.01
6.5
5.3
1.88
1.88
mu/l
0.02
477
4501
512
4943
1.20
0.98
5.7
5.0
5.96
5.91
mmol/l
0.33
475
4556
555
5401
1.25
0.97
20.4
11.6
25.14
25.43
u/l
0.18
546
5261
6
27
2.23
0.93
1.2
2.0
1.00
1.87
u/field
—
6
21
38
495
0.75
0.93
1.1
1.4
—
—
—
0
0
10
55
1.83
0.92
2.8
1.1
—
—
—
0
0
24
169
1.44
0.88
1.5
2.0
—
—
—
0
0
6
33
1.83
0.79
1.7
2.1
63.67
110.07
ng/l
—
6
33
0
25
0.00
0.79
0.0
1.1
—
—
—
0
0
11
67
1.65
0.75
2.3
3.2
—
—
—
0
0
9
54
1.68
0.74
1.1
1.3
—
—
—
0
0
5
24
2.09
0.74
2.2
1.3
—
—
—
0
0
545
5322
1.19
0.73
26.0
13.7
—
—
—
0
0
199
1827
1.13
0.73
4.2
3.6
—
0.86
—
0
7
5
25
2.01
0.73
1.2
1.1
—
—
—
0
0
5
28
1.79
0.66
2.2
1.4
—
—
—
0
0
6
102
0.58
0.62
1.0
1.1
—
—
—
0
0
518
5054
1.15
0.62
5.6
5.0
4.36
4.61
mmol/l
6.44
485
4729
8
50
1.61
0.61
1.1
1.4
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
6.90
—
0
21
492
4791
1.13
0.58
4.9
4.2
1.29
1.25
mmol/l
0.71
456
4431
30
238
1.27
0.58
2.5
2.0
—
—
—
0
0
493
4805
1.12
0.56
7.5
6.3
39.48
39.16
mmol/mol
0.34
460
4526
37
303
1.24
0.55
4.3
2.7
31.38
47.79
u/ml
0.57
37
289
70
612
1.16
0.53
2.2
1.8
—
—
—
0
0
6
40
1.50
0.51
1.2
1.2
—
—
—
0
0
21
268
0.78
0.50
1.6
1.7
—
—
—
0
0
569
5608
1.17
0.48
46.9
23.7
231.42
250.87
e9/l
6.25
563
5508
569
5610
1.16
0.47
46.8
23.7
4.34
4.47
e12/l
7.12
561
5491
8
118
0.67
0.46
1.0
1.3
4.45
3.79
mmol/l
—
8
111
569
5611
1.16
0.46
46.9
23.7
6.92
6.75
e9/l
0.95
562
5491
5
83
0.60
0.46
1.0
1.1
—
—
—
0
0
18
138
1.31
0.46
2.4
1.4
130.06
272.54
pmol/l
0.53
18
133
522
5122
1.12
0.45
6.2
5.7
2.52
2.68
mmol/l
3.94
486
4775
513
5032
1.11
0.43
5.4
4.9
1.37
1.47
mmol/l
7.81
477
4682
8
57
1.41
0.42
1.6
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.9
—
6.73
—
0
15
55
485
1.15
0.40
7.4
3.6
7.32
7.34
ph
0.28
50
344
7
102
0.68
0.40
1.0
1.1
—
—
—
0
0
28
235
1.20
0.36
1.4
1.7
—
—
—
0
0
6
42
1.43
0.35
3.2
3.2
36.93
17.52
mg/l
—
6
32
6
43
1.40
0.35
1.0
1.1
—
—
—
0
0
28
237
1.19
0.34
1.4
1.7
—
—
—
0
0
28
237
1.19
0.34
1.4
1.7
—
—
—
0
0
19
155
1.23
0.32
1.3
1.1
—
—
—
0
0
28
240
1.17
0.30
1.5
1.7
—
—
—
0
0
30
259
1.17
0.30
2.2
2.2
0.00
0.00
estimate
—
9
81
32
278
1.16
0.30
1.3
1.4
34.90
23.83
iu/l
0.78
26
233
7
57
1.23
0.29
1.3
2.4
—
—
—
0
0
15
121
1.25
0.28
1.0
1.1
2.86
2.29
u/ml
—
10
68
11
85
1.30
0.28
1.3
1.9
—
—
—
0
0
43
385
1.13
0.27
1.9
2.3
13.74
12.98
nmol/l
0.17
36
356
25
215
1.17
0.27
1.5
1.3
202.09
277.72
miu/ml
0.52
11
104
14
171
0.81
0.26
15.9
9.9
—
—
—
0
0
66
608
1.10
0.26
2.0
1.7
—
—
—
0
0
6
85
0.70
0.24
1.5
1.5
10.08
24.65
u/l
—
6
75
0
10
0.00
0.21
0.0
16.5
—
76.76
—
0
10
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
22
193
1.15
0.20
1.4
1.7
—
—
—
0
0
156
1506
1.05
0.18
5.1
5.4
2.15
2.46
ug/l
0.40
142
1359
10
82
1.22
0.17
1.2
1.2
—
—
—
0
0
220
2145
1.04
0.16
1.8
1.9
1.48
1.34
mmol/l
1.60
185
1819
25
225
1.12
0.16
1.4
1.7
—
—
—
0
0
12
102
1.18
0.15
1.0
1.1
0.02
0.90
u/ml
—
7
48
12
103
1.17
0.14
1.0
1.1
0.12
1.43
u/ml
—
7
57
16
177
0.90
0.10
1.1
1.1
1.38
1.57
g/l
3.01
16
177
15
135
1.11
0.09
1.9
1.6
—
—
—
0
0
6
54
1.11
0.09
1.0
1.4
—
—
—
0
0
160
1569
1.03
0.08
1.8
1.5
—
—
—
0
0
8
77
1.04
0.07
2.6
2.7
3.96
4.04
mmol/l
—
8
77
8
77
1.04
0.07
2.6
2.7
1.20
1.20
mmol/l
—
8
77
8
77
1.04
0.07
2.6
2.7
104.50
105.53
mmol/l
—
8
77
7
80
0.87
0.07
2.0
1.6
—
—
—
0
0
12
131
0.91
0.05
1.1
1.4
567.00
452.30
mg/l
0.25
12
125
13
120
1.09
0.05
1.5
1.9
—
—
—
0
0
14
150
0.93
0.04
1.1
1.3
—
—
—
0
0
16
151
1.06
0.03
1.1
1.8
49.87
41.58
nmol/l
0.47
16
145
201
2025
0.99
0.03
3.5
3.1
—
—
—
0
0
14
132
1.06
0.02
1.9
1.5
—
—
—
0
0
26
269
0.97
0.02
1.1
1.1
—
—
—
0
0
64
630
1.02
0.02
1.4
1.5
—
—
—
0
0
14
134
1.05
0.00
1.0
1.1
—
—
—
0
0
45
444
1.01
0.00
2.6
2.7
5.89
6.17
ph
1.58
32
301
11
105
1.05
0.00
1.1
1.4
—
—
—
0
0
22
225
0.98
0.00
1.2
1.1
—
—
—
0
0
18
182
0.99
0.00
1.3
1.2
0.91
0.89
g/l
0.15
18
182
42
422
0.99
0.00
1.8
1.8
3.35
3.43
mmol/l
0.19
31
308
89
892
1.00
0.00
3.2
3.2
0.65
0.81
ug/l
1.73
59
575
5
59
0.85
0.00
2.2
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
77.60
—
0
5
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
41.13
—
0
8
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
69
0.87
-0.00
1.3
1.5
364.33
348.29
mu/l
—
6
59
0
8
0.00
-0.00
0.0
1.6
—
59.00
—
0
8
0
5
0.00
-0.00
0.0
2.2
—
0.60
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
3096.50
—
0
6

Mortality – FinRegistry

Association

Association between endpoint D3_HAEMORRHAGICNAS and mortality.

Females

Parameter HR [95% CI] p-value
D3_HAEMORRHAGICNAS 2.577 [2.13, 3.11] < 0.001
Birth year 0.996 [0.99, 1.0] 0.377

During the follow-up period (1.1.1998 — 31.12.2019), 542 out of 1833 females with D3_HAEMORRHAGICNAS died.

Males

Parameter HR [95% CI] p-value
D3_HAEMORRHAGICNAS 2.773 [2.18, 3.53] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 549 out of 1402 males with D3_HAEMORRHAGICNAS died.

Mortality risk

Mortality risk for people of age

years, who have D3_HAEMORRHAGICNAS.

N-year risk Females Males
1 0.304% 0.488%
5 1.55% 3.02%
10 3.838% 7.322%
15 6.969% 14.394%
20 12.299% 23.449%

Relationships between endpoints

Index endpoint: D3_HAEMORRHAGICNAS – Other and unspecified haemorrhagic conditions

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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