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Carcinoma in situ of oral cavity

CD2_INSITU_ORALCAVITY

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

  • not C3_ORALCAVITY
556287

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C0[1-6]
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 2

1 out of 7 registries used, show all original rules.

49

4. Check minimum number of events

None

49

5. Include endpoints

101

6. Filter based on genotype QC (FinnGen only)

89

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF12
Parent code in ICD-10
D00-D09
Name in latin
Carcinoma in situ labii (oris)

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 89 36 53
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 70.10 70.86 69.58

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
92
Matched controls
920
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
105.9
32.6
34
5
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
29.5
19.6
26
12
K13.29
ICD-10 Finland
Indefinite leukoplakia
+∞
18.3
17
*
D00.00
ICD-10 Finland
Cancer in situ on the lip red border
+∞
18.3
17
*
EJB10
NOMESCO Finland
Excision of tumor or other lesion of apex or body of tongue
73.6
16.4
18
*
K13.78
ICD-10 Finland
Other change in the oral mucosa
27.9
15.0
20
9
SAA03
NOMESCO Finland
Extended examination of mouth
5.1
13.5
57
223
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
+∞
12.8
12
*
8070/2-C00.1
ICD-O-3
Squamous cell carcinoma in situ, NOS, of external lower lip
+∞
11.7
11
*
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
17.0
11.0
17
12
D00.06
ICD-10 Finland
Cancer in situ in another part of the tongue
+∞
9.5
9
*
EJB30
NOMESCO Finland
Excision of tumor or other lesion of floor of the mouth
98.7
8.6
9
*
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
+∞
8.5
8
*
EAA30
NOMESCO Finland
Partial excision of lower lip
+∞
8.5
8
*
EAA10
NOMESCO Finland
Excision of lesion of lip
86.8
7.5
8
*
C021, 8077, 2
ICD-O-3
+∞
7.4
7
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
24.6
6.8
9
*
WX110
NOMESCO Finland
Infiltration anesthesia
4.0
6.8
75
482
K13.20
ICD-10 Finland
Idiopathic leukoplakia
74.8
6.5
7
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
74.8
6.5
7
*
D00.05
ICD-10 Finland
In situ cancer of the pharyngeal part of the tongue
+∞
6.3
6
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
4.2
6.3
19
54

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
30
102
3.88
7.88
1.6
1.3
—
—
—
0
0
57
296
3.43
7.67
3.7
2.3
—
—
—
0
0
25
101
3.03
4.81
1.5
1.6
—
—
—
0
0
59
419
2.14
3.01
9.3
7.3
1.19
1.21
mmol/l
0.53
50
366
17
73
2.63
2.85
1.6
2.8
0.23
0.21
g/l
0.32
17
64
53
369
2.03
2.76
3.8
2.6
—
—
estimate
—
0
0
20
98
2.33
2.55
1.3
1.4
—
—
—
0
0
16
75
2.37
2.24
6.4
11.1
—
—
—
0
0
16
76
2.34
2.18
1.8
1.3
—
—
—
0
0
5
10
5.21
2.10
7.0
1.2
—
—
—
0
0
23
133
1.97
1.93
2.5
3.1
1.40
2.18
e6/l
—
10
71
43
311
1.72
1.74
3.3
4.1
67.23
93.91
e6/l
0.20
26
222
36
248
1.74
1.73
3.0
3.1
1.17
0.45
e6/l
0.77
23
178
40
286
1.71
1.68
3.1
3.3
67.87
258.16
e6/l
0.38
26
215
8
32
2.64
1.64
1.4
2.0
—
—
—
0
0
18
101
1.97
1.63
6.7
9.4
7.43
7.42
ph
—
8
59
34
234
1.72
1.63
2.9
3.0
—
—
estimate
—
0
0
6
20
3.13
1.61
5.3
1.8
—
—
—
0
0
25
161
1.76
1.49
1.5
1.8
1588.20
1216.86
nmol/l
0.96
17
126
37
266
1.65
1.49
3.7
2.3
—
—
—
0
0
54
429
1.63
1.45
9.7
15.8
1.29
1.30
inr
0.01
43
351
11
55
2.14
1.33
1.2
1.3
—
—
—
0
0
28
194
1.64
1.27
1.5
1.4
—
—
—
0
0
35
257
1.58
1.26
6.1
4.0
7.40
7.40
ph
0.45
22
186
14
80
1.88
1.21
1.3
1.5
—
—
—
0
0
83
761
1.93
1.11
18.8
16.4
—
—
—
0
0
37
282
1.52
1.11
5.2
5.3
—
—
—
0
0
14
84
1.79
1.05
1.8
1.9
—
—
—
0
0
7
36
2.02
0.99
3.7
2.8
—
—
—
0
0
51
423
1.46
0.98
7.3
6.0
0.15
0.20
e9/l
1.83
46
358
19
128
1.61
0.95
7.3
7.4
102.74
104.22
mmol/l
0.39
19
128
46
379
1.43
0.89
2.3
2.2
104.78
93.91
pmol/l
0.48
20
194
8
46
1.81
0.85
2.5
2.5
0.66
0.66
%
—
8
46
35
278
1.42
0.82
4.4
3.4
43.20
73.30
mg/l
0.80
28
187
0
24
0.00
0.80
0.0
1.3
—
—
—
0
0
20
268
0.68
0.77
3.6
3.5
—
—
—
0
0
5
24
2.14
0.76
1.0
1.1
—
—
—
0
0
10
60
1.75
0.75
7.2
10.8
23.81
25.00
mmol/l
—
10
60
18
127
1.52
0.75
3.0
1.7
—
—
—
0
0
32
254
1.40
0.74
6.2
4.3
—
—
—
0
0
78
722
1.53
0.70
8.6
7.1
42.50
40.44
mmol/mol
0.84
73
674
32
257
1.38
0.69
2.0
1.8
18.38
20.65
nmol/l
0.48
25
212
11
70
1.65
0.69
11.8
1.9
—
—
—
0
0
5
28
1.83
0.67
1.0
1.2
—
—
—
0
0
60
533
1.36
0.67
4.7
4.8
—
—
—
0
0
8
49
1.69
0.64
2.5
2.5
1.69
1.46
%
—
8
49
6
36
1.71
0.58
1.8
1.1
—
—
—
0
0
12
82
1.53
0.58
9.0
4.0
7.39
7.34
ph
—
7
52
26
317
0.75
0.55
4.4
3.9
—
—
—
0
0
15
109
1.45
0.55
1.5
1.7
—
—
—
0
0
47
412
1.29
0.53
7.6
5.8
0.04
0.04
e9/l
0.31
40
342
47
412
1.29
0.53
7.6
5.8
0.61
0.61
e9/l
0.01
39
344
79
744
1.44
0.52
25.9
17.7
36.27
25.17
mg/l
1.33
68
637
47
416
1.27
0.48
7.7
5.8
1.58
1.82
e9/l
1.07
42
357
5
32
1.59
0.43
1.2
1.0
—
—
—
0
0
34
293
1.25
0.42
5.1
4.0
9.60
12.45
mg/mmol
0.27
25
186
8
59
1.39
0.42
1.5
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
2.5
—
57.16
—
0
15
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.50
0.41
2.0
2.4
1.10
1.66
mg/l
—
5
29
11
80
1.43
0.40
2.1
2.2
362.91
393.40
nmol/l
0.22
11
73
9
66
1.40
0.40
1.1
1.4
—
—
—
0
0
5
36
1.41
0.39
2.6
2.7
—
—
—
0
0
14
176
0.76
0.36
9.9
5.3
—
—
—
0
0
12
91
1.37
0.36
2.9
3.5
7.37
7.39
ph
—
6
57
26
223
1.23
0.33
2.5
3.3
—
0.29
—
0
7
7
56
1.27
0.30
2.9
1.3
0.87
1.32
g/l
—
7
48
8
62
1.32
0.29
1.6
3.2
—
—
—
0
0
61
573
1.19
0.29
3.9
4.3
14.94
14.93
pmol/l
0.02
55
518
17
143
1.23
0.25
1.2
1.3
20.25
31.10
iu/ml
—
6
48
36
327
1.17
0.25
1.7
2.0
1.39
1.30
mmol/l
0.26
29
268
71
738
0.83
0.24
6.3
5.7
6.28
6.06
mmol/l
0.57
64
672
48
448
1.15
0.22
15.1
9.9
4.31
4.23
e9/l
0.08
42
385
5
42
1.20
0.22
4.8
3.5
1.38
1.45
%
—
5
37
78
755
1.22
0.21
6.5
6.4
2.33
2.57
mmol/l
1.84
71
693
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.8
—
5.97
—
0
10
0
10
0.00
0.21
0.0
2.0
—
1.72
—
0
10
0
12
0.00
0.21
0.0
3.8
—
73.33
—
0
12
38
350
1.15
0.21
10.5
12.6
0.00
0.00
e9/l
0.50
30
280
0
13
0.00
0.21
0.0
4.2
—
1.52
—
0
13
6
51
1.19
0.20
1.2
1.5
—
—
—
0
0
74
719
1.15
0.15
4.7
4.6
1.52
1.28
mmol/l
1.10
67
653
46
436
1.11
0.15
3.1
4.3
0.00
0.00
estimate
—
5
84
25
232
1.11
0.11
9.0
6.6
—
—
—
0
0
11
97
1.15
0.09
1.4
1.3
—
—
—
0
0
6
53
1.14
0.09
5.7
4.2
—
—
—
0
0
5
60
0.82
0.08
2.0
4.4
—
—
—
0
0
7
65
1.08
0.08
3.3
5.1
1.23
1.22
mmol/l
—
7
59
28
268
1.06
0.05
3.9
3.2
—
—
—
0
0
20
189
1.07
0.05
3.8
4.2
1.01
1.02
kg/l
1.19
13
118
36
348
1.06
0.05
3.7
4.3
30.00
45.51
ng/l
0.79
25
277
75
741
1.07
0.03
5.5
5.6
4.25
4.46
mmol/l
1.08
67
682
10
107
0.93
0.02
1.2
1.3
—
—
—
0
0
42
427
0.97
0.01
3.0
4.2
0.00
0.00
estimate
—
7
89
74
738
1.01
0.00
5.5
5.5
1.40
1.43
mmol/l
0.21
66
674
34
342
0.99
0.00
2.9
3.8
6.63
6.15
ph
1.17
15
197
55
554
0.98
0.00
4.5
4.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
6.24
—
0
8
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
171.76
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
6.84
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
15.95
—
0
8
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.4
—
0.75
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
71
0.98
-0.00
1.9
2.0
—
0.17
estimate
—
0
18
0
8
0.00
-0.00
0.0
2.1
—
6.44
—
0
8
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
12.76
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.2
—
57.00
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
289.83
—
0
6
43
430
1.00
-0.00
3.0
4.3
0.00
0.00
estimate
—
7
94
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
84.83
—
0
6
0
8
0.00
-0.00
0.0
1.6
—
2.11
—
0
8
0
8
0.00
-0.00
0.0
1.6
—
0.26
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
1.70
—
0
6
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_ORALCAVITY – Carcinoma in situ of oral cavity

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).