Carcinoma in situ of oral cavity and pharynx

CD2_INSITU_OROPHARYNX

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

  • not C3_OROPHARYNX
557086

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

3 out of 7 registries used, show all original rules.

62

4. Check minimum number of events

None

62

5. Include endpoints

None

62

6. Filter based on genotype QC (FinnGen only)

56

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D00

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 56 20 36
Unadjusted period prevalence (%) 0.01 0.01 0.02
Median age at first event (years) 64.46 69.65 61.58

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
57
Matched controls
570
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
285.2
31.1
29
*
D00.06
ICD-10 Finland
Cancer in situ in another part of the tongue
+∞
22.3
20
*
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
236.5
17.5
17
*
EJB10
NOMESCO Finland
Excision of tumor or other lesion of apex or body of tongue
69.3
17.3
19
*
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
43.4
13.4
16
5
SAA03
NOMESCO Finland
Extended examination of mouth
7.7
13.1
39
125
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
8.3
12.0
20
35
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
27.0
12.0
16
8
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
74.4
11.1
12
*
EJB30
NOMESCO Finland
Excision of tumor or other lesion of floor of the mouth
133.6
10.8
11
*
ECA20
NOMESCO Finland
Biopsy of gingiva
133.6
10.8
11
*
D00.04
ICD-10 Finland
In situ cancer of the floor of the mouth
+∞
10.7
10
*
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
+∞
10.7
10
*
EKA10
NOMESCO Finland
iopsy of buccal mucosa
25.8
10.4
14
7
K13.78
ICD-10 Finland
Other change in the oral mucosa
27.4
9.9
13
6
EP1AE
NOMESCO Finland
Neck ultrasound examination
12.0
9.7
18
21
D00.01
ICD-10 Finland
In situ cancer of the mucous membrane of the cheek
+∞
9.6
9
*
8070/3-C02.1
ICD-O-3
Squamous cell carcinoma, NOS, of border of tongue
+∞
8.5
8
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
52.5
8.0
9
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
29.7
7.9
10
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
91.5
7.6
8
*
D00.05
ICD-10 Finland
In situ cancer of the pharyngeal part of the tongue
+∞
7.4
7
*
GBB00
NOMESCO Finland
Tracheostomy
34.9
7.4
9
*
WZC00
NOMESCO Finland
Treatment plan or consultation
4.5
7.4
33
133
SBA00
NOMESCO Finland
Microbiological examinations
16.6
7.2
11
8
EKB00
NOMESCO Finland
Excision of tumour or other lesion of cheek
45.6
6.9
8
*
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
26.2
6.9
9
*
EHA10
NOMESCO Finland
Biopsy of palate
78.3
6.6
7
*
K13.20
ICD-10 Finland
Idiopathic leukoplakia
78.3
6.6
7
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
78.3
6.6
7
*
130
Kela drug reimbursment
Malignant tumour
6.5
6.4
17
35
K13.29
ICD-10 Finland
Indefinite leukoplakia
30.4
6.4
8
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
37
207
3.24
4.35
4.1
2.7
—
—
estimate
—
0
0
16
54
3.73
4.25
1.7
1.2
—
—
—
0
0
14
44
3.89
4.10
9.9
10.3
—
—
—
0
0
28
144
2.86
3.66
3.4
2.8
—
—
—
0
0
31
169
2.83
3.62
4.2
2.1
—
—
—
0
0
13
44
3.53
3.39
1.6
1.3
—
—
—
0
0
25
130
2.64
3.10
10.0
6.6
—
—
—
0
0
16
67
2.93
2.95
2.1
1.7
—
—
—
0
0
9
209
0.32
2.91
3.4
3.5
—
—
—
0
0
17
75
2.81
2.85
8.6
7.9
102.76
104.13
mmol/l
0.32
17
75
18
84
2.67
2.71
4.4
6.7
0.92
1.03
mmol/l
1.53
18
75
38
255
2.47
2.60
10.4
6.8
11.74
11.58
umol/l
0.03
38
243
36
241
2.34
2.41
9.5
7.1
0.64
0.61
e9/l
0.38
31
207
36
242
2.32
2.37
9.5
7.1
0.04
0.04
e9/l
0.27
31
209
21
118
2.23
2.07
1.5
1.4
—
—
—
0
0
9
34
2.95
1.97
2.4
2.6
2.13
1.36
%
—
9
34
9
34
2.95
1.97
2.4
2.6
0.72
0.64
%
—
9
34
24
145
2.13
1.96
5.6
5.1
—
—
—
0
0
8
28
3.15
1.95
2.0
3.0
25.15
24.23
mmol/l
—
8
28
8
28
3.15
1.95
1.1
1.7
—
—
—
0
0
25
154
2.11
1.94
7.1
6.8
—
—
—
0
0
31
212
2.01
1.78
2.7
2.1
96.91
93.07
pmol/l
0.20
19
106
14
70
2.33
1.78
1.4
1.6
—
—
—
0
0
35
252
2.01
1.72
15.7
14.4
1.16
1.27
inr
0.76
29
206
13
64
2.34
1.70
1.2
1.8
—
—
—
0
0
11
50
2.49
1.69
2.2
4.1
6.18
5.39
umol/l
0.17
11
44
10
43
2.60
1.69
1.2
1.7
—
—
—
0
0
15
79
2.22
1.69
1.5
1.8
—
—
—
0
0
13
65
2.30
1.64
13.1
8.7
-0.30
0.98
mmol/l
0.72
13
51
13
65
2.30
1.64
13.2
8.6
7.44
7.43
ph
—
6
35
39
295
2.02
1.63
8.4
5.5
6.94
6.67
mmol/l
0.33
39
281
9
38
2.62
1.54
2.2
3.1
131.00
131.92
g/l
—
9
38
21
134
1.90
1.41
2.7
3.1
—
—
estimate
—
0
0
5
20
2.64
1.17
1.0
1.2
—
—
—
0
0
8
40
2.16
1.17
4.9
3.6
—
—
—
0
0
7
30
2.51
1.17
5.6
4.2
36.90
36.90
°c
—
7
30
14
84
1.88
1.10
2.4
1.8
—
—
—
0
0
21
144
1.73
1.08
3.5
4.6
7.40
7.40
ph
0.03
14
104
21
144
1.73
1.08
3.1
3.0
0.33
0.23
e6/l
0.20
15
101
7
34
2.20
1.07
15.9
8.4
24.24
24.86
mmol/l
—
7
34
9
50
1.95
1.02
2.6
2.3
444.67
378.80
nmol/l
—
9
44
9
50
1.95
1.02
3.2
4.5
3.14
12.70
ug/l
—
9
41
10
55
1.99
0.99
2.9
3.6
1.22
1.88
mmol/l
—
10
47
43
366
1.71
0.92
15.1
8.2
86.91
74.95
u/l
1.02
43
347
28
216
1.58
0.89
12.3
14.3
0.00
0.00
e9/l
-0.00
21
176
18
129
1.58
0.76
3.2
3.5
—
—
—
0
0
36
301
1.53
0.76
5.4
4.8
—
23.13
—
0
8
5
25
2.09
0.74
5.4
3.6
—
—
—
0
0
7
41
1.80
0.73
1.3
1.5
—
—
—
0
0
8
53
1.59
0.61
2.4
2.1
—
—
—
0
0
0
20
0.00
0.61
0.0
3.3
—
200.17
—
0
12
23
183
1.43
0.58
3.7
4.1
7.68
37.93
e6/l
1.06
14
132
6
39
1.60
0.55
5.5
3.2
7.43
7.43
ph
—
6
33
21
169
1.38
0.48
3.5
3.3
18.11
20.54
e6/l
0.11
16
128
0
15
0.00
0.42
0.0
1.1
—
—
—
0
0
15
117
1.38
0.40
6.4
4.0
1.02
1.02
kg/l
—
10
72
0
18
0.00
0.40
0.0
2.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.6
—
12.31
—
0
18
5
35
1.47
0.40
1.6
1.4
—
—
—
0
0
5
35
1.47
0.40
9.6
3.7
—
—
—
0
0
5
35
1.47
0.40
1.8
1.0
—
—
—
0
0
6
44
1.41
0.36
3.0
2.5
—
0.00
estimate
—
0
9
50
479
1.36
0.25
23.9
15.9
—
—
—
0
0
48
457
1.32
0.22
34.1
18.0
37.16
22.88
mg/l
1.80
41
383
0
10
0.00
0.21
0.0
2.9
—
10.49
—
0
10
25
225
1.20
0.21
4.6
4.6
14.95
30.16
ng/l
2.62
20
173
6
48
1.28
0.21
1.5
1.3
—
—
—
0
0
18
202
0.84
0.18
1.6
1.9
1.29
1.37
mmol/l
0.17
13
167
24
218
1.17
0.17
4.6
3.9
6.58
6.11
ph
0.71
13
123
12
112
1.09
0.03
9.8
6.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
6.76
—
0
8
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.5
—
87.22
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
31.78
—
0
8
0
6
0.00
0.00
0.0
1.2
—
32.17
—
0
6
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
3.1
—
14.38
—
0
8
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.8
—
295.60
—
0
5
0
5
0.00
-0.00
0.0
2.2
—
40.46
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
71
0.98
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
11.6
—
6.74
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
200.69
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_OROPHARYNX – Carcinoma in situ of oral cavity and pharynx

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).