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Carcinoma in situ of lip, oral cavity and pharynx

DOID Endpoint Browser PheWeb

CD2_INSITU_LIPORALPHARYNX

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D00.0
  • Hospital discharge: ICD-9 — 2300
  • Cause of death: ICD-10 — D00.0
  • Cause of death: ICD-9 — 2300

2 out of 7 registries used, show all original rules.

108

4. Check minimum number of events

None

108

5. Include endpoints

None

108

6. Filter based on genotype QC (FinnGen only)

95

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D00
Name in latin
Carcinoma in situ labii (oris)

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 95 34 61
Unadjusted period prevalence (%) 0.02 0.01 0.03
Median age at first event (years) 67.24 67.23 67.25

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
96
Matched controls
960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
259.0
35.3
34
*
D00.00
ICD-10 Finland
Cancer in situ on the lip red border
+∞
28.6
26
*
D00.06
ICD-10 Finland
Cancer in situ in another part of the tongue
+∞
21.7
20
*
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
249.3
20.4
20
*
EJB10
NOMESCO Finland
Excision of tumor or other lesion of apex or body of tongue
52.9
18.1
21
5
SAA03
NOMESCO Finland
Extended examination of mouth
5.7
16.4
58
202
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
29.3
15.9
21
9
EP1AE
NOMESCO Finland
Neck ultrasound examination
8.6
15.6
23
34
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
6.6
15.3
31
65
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
27.6
15.0
20
9
ECA20
NOMESCO Finland
Biopsy of gingiva
175.6
14.9
15
*
TEA00
NOMESCO Finland
Biopsy of lip
87.6
14.0
15
*
D00.09
ICD-10 Finland
Unspecified cancer in situ in oral cavity and throat
+∞
12.8
12
*
EJB30
NOMESCO Finland
Excision of tumor or other lesion of floor of the mouth
148.6
12.8
13
*
EAA10
NOMESCO Finland
Excision of lesion of lip
74.3
11.9
13
*
EAA30
NOMESCO Finland
Partial excision of lower lip
+∞
11.7
11
*
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
+∞
11.7
11
*
K13.78
ICD-10 Finland
Other change in the oral mucosa
25.0
11.1
15
7
EKA10
NOMESCO Finland
iopsy of buccal mucosa
15.6
10.6
17
13
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
37.1
10.6
13
*
D00.04
ICD-10 Finland
In situ cancer of the floor of the mouth
+∞
10.6
10
*
SBA00
NOMESCO Finland
Microbiological examinations
19.4
10.3
15
9
D00.01
ICD-10 Finland
In situ cancer of the mucous membrane of the cheek
+∞
9.5
9
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
40.9
9.2
11
*
A07AA02
ATC
nystatin; oral
7.8
9.1
21
33
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
55.2
8.9
10
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
22.5
8.7
12
6
C03.0
ICD-10 Finland
Malignant neoplasm: Upper gum
98.3
8.6
9
*
EKB00
NOMESCO Finland
Excision of tumour or other lesion of cheek
98.3
8.6
9
*
8070/3-C02.1
ICD-O-3
Squamous cell carcinoma, NOS, of border of tongue
+∞
8.4
8
*
WZC00
NOMESCO Finland
Treatment plan or consultation
3.5
8.4
52
243
EJ2S1
NOMESCO Finland
Photography of oral mucosa
49.1
7.9
9
*
B37.03
ICD-10 Finland
Chronic atrophic candida infection in the mouth
+∞
7.4
7
*
D00.05
ICD-10 Finland
In situ cancer of the pharyngeal part of the tongue
+∞
7.4
7
*
C00.1
ICD-10 Finland
Malignant neoplasm: External lower lip
+∞
7.4
7
*
D00.08
ICD-10 Finland
Other specified cancers in situ in oral cavity and throat
+∞
7.4
7
*
8070/3-C00.1
ICD-O-3
Squamous cell carcinoma, NOS, of external lower lip
+∞
7.4
7
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
22.0
7.3
10
5
K13.29
ICD-10 Finland
Indefinite leukoplakia
22.0
7.3
10
5
SBB10
NOMESCO Finland
Dental impressions
7.9
6.8
15
22
GBB00
NOMESCO Finland
Tracheostomy
24.5
6.8
9
*
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
24.5
6.8
9
*
K05.31
ICD-10 Finland
Periodontitis pronounced
4.1
6.6
21
62
WX110
NOMESCO Finland
Infiltration anesthesia
3.6
6.6
75
481
EBB10
NOMESCO Finland
Insertion of dental implant
74.6
6.5
7
*
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
74.6
6.5
7
*
C03.1
ICD-10 Finland
Malignant neoplasm: Lower gum
74.6
6.5
7
*
EDB00
NOMESCO Finland
Partial excision of mandible
74.6
6.5
7
*
EHA10
NOMESCO Finland
Biopsy of palate
74.6
6.5
7
*
SXA10
NOMESCO Finland
Oral mucosal sampling
19.6
6.4
9
5
C06.0
ICD-10 Finland
Malignant neoplasm: Cheek mucosa
+∞
6.3
6
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
7.3
6.1
14
22
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.9
6.0
48
248

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
29
72
5.34
11.69
2.9
2.6
0.21
0.21
g/l
0.05
29
62
52
290
2.73
5.52
4.2
2.2
—
—
—
0
0
26
101
3.16
5.36
1.9
1.2
—
—
—
0
0
31
135
2.91
5.23
6.5
7.2
103.52
103.77
mmol/l
0.07
31
135
26
103
3.09
5.17
2.0
1.6
—
—
—
0
0
21
77
3.21
4.72
1.6
1.3
—
—
—
0
0
21
79
3.12
4.52
7.2
9.5
—
—
—
0
0
44
257
2.31
3.89
2.1
1.9
15.04
21.99
nmol/l
3.86
39
213
55
363
2.21
3.52
4.2
2.7
—
—
estimate
—
0
0
27
134
2.41
3.39
2.7
1.8
—
—
—
0
0
13
298
0.35
3.28
3.2
3.5
—
—
—
0
0
26
130
2.37
3.19
1.7
1.8
27.95
28.78
s
0.49
26
124
20
89
2.58
3.13
3.3
2.9
19.10
9.34
umol/l
0.41
20
76
20
91
2.51
2.99
4.5
4.0
7.38
7.38
ph
0.04
15
59
13
48
2.98
2.85
3.7
2.5
0.71
0.64
%
0.45
13
48
57
404
2.01
2.79
10.1
6.4
0.62
0.62
e9/l
0.06
47
347
13
49
2.91
2.75
3.7
2.5
2.02
1.16
%
0.81
13
49
57
407
1.99
2.70
10.1
6.4
0.04
0.04
e9/l
0.19
48
350
40
253
2.00
2.68
3.9
2.6
—
—
—
0
0
58
418
1.98
2.66
10.1
6.6
0.15
0.19
e9/l
2.07
52
357
23
118
2.25
2.64
8.4
7.9
7.41
7.42
ph
0.13
13
74
57
411
1.95
2.58
10.1
6.5
1.76
1.74
e9/l
0.08
51
360
19
91
2.36
2.54
1.4
1.4
400.00
402.11
titre
—
5
19
52
369
1.89
2.42
2.6
2.1
89.94
93.97
pmol/l
0.29
32
183
22
116
2.16
2.35
8.7
7.9
5.15
4.98
kpa
0.29
22
111
22
116
2.16
2.35
8.8
7.9
13.48
11.20
kpa
1.06
22
111
36
231
1.89
2.24
9.9
6.4
—
—
—
0
0
5
9
5.79
2.24
16.6
1.6
4.74
4.31
nmol/l
—
5
9
43
298
1.80
2.07
3.8
3.5
47.24
235.10
e6/l
0.43
36
237
38
255
1.81
2.03
3.6
3.3
0.35
0.46
e6/l
0.23
31
192
31
196
1.86
1.99
1.5
1.5
—
—
—
0
0
6
16
3.93
1.96
1.5
1.1
—
—
—
0
0
58
448
1.74
1.86
12.6
15.9
1.22
1.27
inr
0.38
50
385
35
238
1.74
1.75
3.5
3.2
—
—
estimate
—
0
0
39
274
1.71
1.73
8.2
4.6
—
—
—
0
0
10
42
2.54
1.67
1.3
1.9
—
—
—
0
0
58
457
1.68
1.65
17.7
10.7
4.12
4.39
e9/l
0.41
53
395
49
372
1.65
1.60
7.5
6.6
25.23
25.84
%
0.12
44
354
13
65
2.16
1.57
1.3
1.4
—
—
—
0
0
51
393
1.64
1.55
12.7
6.8
1.19
1.21
mmol/l
0.75
51
362
5
15
3.46
1.54
5.4
1.3
8.20
17.50
ug/l
—
5
15
15
253
0.52
1.53
3.4
3.9
0.00
0.00
estimate
—
5
85
48
367
1.62
1.49
7.5
6.5
8.98
8.81
%
0.19
43
345
7
28
2.61
1.48
2.1
2.6
—
—
—
0
0
16
89
1.96
1.48
1.2
1.7
—
—
—
0
0
43
322
1.61
1.44
4.0
4.4
115.72
73.05
e6/l
0.20
32
246
13
69
2.02
1.36
4.1
3.7
—
—
—
0
0
12
63
2.03
1.29
1.2
1.6
—
—
—
0
0
35
261
1.54
1.15
3.9
3.4
—
—
—
0
0
7
30
2.44
1.15
1.1
1.3
—
—
—
0
0
7
30
2.44
1.15
10.1
2.8
1.34
3.42
ratio
—
7
15
35
262
1.53
1.13
7.7
6.1
—
—
—
0
0
8
41
2.04
1.11
3.5
4.3
1.02
1.02
ratio
—
8
36
17
107
1.72
1.09
1.4
1.6
—
—
—
0
0
20
132
1.65
1.08
3.0
3.0
1.51
2.11
e6/l
0.26
12
73
35
266
1.50
1.04
7.9
4.8
7.41
7.39
ph
0.72
24
196
9
49
1.92
1.02
6.7
5.0
1.73
1.50
%
—
9
44
83
757
1.71
0.99
35.9
18.8
38.07
26.00
mg/l
1.57
70
645
26
188
1.53
0.97
5.7
4.8
1.02
1.02
kg/l
0.67
20
126
7
37
1.96
0.96
2.9
2.6
—
—
—
0
0
44
358
1.42
0.90
12.3
14.3
0.00
0.00
e9/l
0.79
36
300
8
45
1.85
0.87
5.5
3.8
36.91
36.91
°c
—
8
45
35
276
1.42
0.84
4.9
4.0
5.86
11.69
mg/mmol
0.79
29
176
10
58
1.81
0.83
2.3
1.9
1.13
1.22
g/l
—
10
50
0
26
0.00
0.79
0.0
1.0
—
—
—
0
0
11
67
1.72
0.79
5.6
2.7
10.62
9.69
g/l
0.36
11
57
17
118
1.54
0.76
1.6
1.7
—
—
—
0
0
13
86
1.59
0.70
2.1
2.7
371.77
360.27
nmol/l
0.09
13
77
15
103
1.54
0.70
2.8
4.4
5.05
113.29
ug/l
0.81
15
87
7
42
1.72
0.70
1.6
1.3
84.07
486.86
u/ml
—
7
37
5
27
1.90
0.69
13.0
17.6
—
—
—
0
0
10
65
1.60
0.58
6.9
3.7
—
—
—
0
0
9
62
1.50
0.55
11.3
7.6
23.56
25.28
mmol/l
—
9
62
7
45
1.60
0.50
9.3
3.3
—
—
—
0
0
42
369
1.25
0.44
5.0
4.8
19.79
45.08
ng/l
2.11
35
300
39
441
0.81
0.43
5.6
4.6
0.00
0.00
estimate
—
6
113
15
115
1.36
0.42
1.0
1.2
—
—
—
0
0
9
69
1.34
0.38
8.4
2.9
7.40
7.43
ph
—
9
56
39
437
0.82
0.38
5.4
4.5
0.00
0.00
estimate
—
6
110
12
91
1.36
0.36
2.8
2.0
—
—
—
0
0
16
128
1.30
0.34
1.5
1.4
1.20
14.42
u/ml
—
5
47
81
775
1.29
0.33
26.7
16.6
—
—
—
0
0
10
76
1.35
0.29
3.3
2.2
—
0.00
estimate
—
0
22
24
276
0.83
0.29
5.5
4.5
0.00
0.02
estimate
—
5
100
9
72
1.28
0.26
13.7
2.0
—
—
—
0
0
18
152
1.23
0.26
1.8
1.6
3.03
2.93
g/l
0.05
13
91
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
4.6
—
318.73
—
0
11
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
3.4
—
17.58
—
0
13
11
92
1.22
0.17
1.4
1.4
—
—
—
0
0
42
446
0.90
0.16
5.5
4.6
0.00
0.00
estimate
—
5
100
6
79
0.74
0.16
1.7
4.6
1.22
1.22
mmol/l
—
6
70
36
348
1.06
0.05
4.9
4.2
6.43
6.19
ph
0.51
23
200
63
623
1.03
0.01
39.5
23.4
14.20
13.85
%
1.02
63
617
14
138
1.02
0.00
1.4
1.3
38.08
35.07
iu/ml
—
6
48
24
237
1.02
0.00
2.1
3.1
0.50
0.79
ug/l
1.39
14
159
19
189
1.01
0.00
12.3
5.8
—
—
—
0
0
6
59
1.02
-0.00
1.7
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
0.00
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
179.26
—
0
7
6
65
0.92
-0.00
1.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
16.30
—
0
7
0
7
0.00
-0.00
0.0
5.4
—
49.71
—
0
7
0
6
0.00
-0.00
0.0
2.8
—
0.50
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
81.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
85.00
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: CD2_INSITU_LIPORALPHARYNX – Carcinoma in situ of lip, oral cavity and pharynx

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).