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Benign neoplasm: Peripheral nerves and autonomic nervous system

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_PERIPH_AUTO_NEURO

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D36.1&
  • Hospital discharge: ICD-9 — 2258
  • Hospital discharge: ICD-8 — 225[5-6]
  • Cause of death: ICD-10 — D36.1&
  • Cause of death: ICD-9 — 2258
  • Cause of death: ICD-8 — 225[5-6]

2 out of 7 registries used, show all original rules.

658

4. Check minimum number of events

None

658

5. Include endpoints

None

658

6. Filter based on genotype QC (FinnGen only)

595

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D36
Name in latin
Neoplasma benignum nervi peripherici

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3668 2092 1552
Only index persons 3125 1824 1301
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.04
Only index persons 0.06 0.07 0.05
Median age at first event (years)
Whole population 48.92 49.76 47.77
Only index persons 47.22 48.14 45.92

-FinnGen-

Key figures

All Female Male
Number of individuals 595 340 255
Unadjusted period prevalence (%) 0.12 0.12 0.12
Median age at first event (years) 50.33 49.63 51.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
615
Matched controls
6150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D36.1
ICD-10 Finland
Benign neoplasm: Peripheral nerves and autonomic nervous system
12712.5
307.7
446
*
22550
ICD-8 Finland
Benign neoplasm of brain and other parts of nervous system, Peripheral nerves
+∞
117.6
109
*
ACB19
NOMESCO Finland
Excision of lesion of peripheral nerve other or unspecified
152.6
65.3
68
5
2258X
ICD-9 Finland
Benign neoplasm of brain and other parts of nervous system, Other specified sites of nervous system
+∞
62.6
59
*
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
8.5
35.4
47
59
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
11.6
30.4
32
29
D48.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Peripheral nerves and autonomic nervous system
151.9
27.9
29
*
D33.45
ICD-10 Finland
Benign Schwannom in the nerve root of the spinal cord
151.9
27.9
29
*
R22.4
ICD-10 Finland
Localized swelling, mass and lump, lower limb
6.6
24.7
41
66
Q85.00
ICD-10 Finland
Neurofibromatosis, type 1
+∞
24.1
23
*
Q85.09
ICD-10 Finland
Unspecified neurofibromatosis
+∞
23.1
22
*
N03AX16
ATC
[U] pregabalin
2.4
21.0
194
988
R22.3
ICD-10 Finland
Localized swelling, mass and lump, upper limb
6.3
19.7
34
57
2401
FHL
Nerve exploration (includes biopsy and removal of local change)
47.7
19.3
23
5
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
5.0
19.2
43
92
R22.2
ICD-10 Finland
Localized swelling, mass and lump, trunk
4.6
17.3
42
96
Q85.0
ICD-10 Finland
Neurofibromatosis (nonmalignant)
+∞
14.6
14
*
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
2.7
14.6
83
331
D48.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Neoplasm of uncertain or unknown behaviour, unspecified
5.2
14.4
30
60
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
+∞
13.6
13
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
3.7
12.9
41
115
Z31.5
ICD-10 Finland
Genetic counselling
3.4
12.9
48
150
D21.1
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of upper limb, including shoulder
12.6
12.7
22
18
9560/0-C72.9
ICD-O-3
Schwannoma, NOS, of nervous system, NOS
+∞
12.5
12
*
N03AX12
ATC
[U] gabapentin; oral
2.2
12.5
130
680
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
9.6
12.1
24
26
ACB99
NOMESCO Finland
Other operation for lesion of peripheral nerve: other or unspecified
47.6
11.9
14
*
S04
ICPC
Lump/swelling localized
2.4
11.4
84
379
D21.2
ICD-10 Finland
Benign neoplasm: Connective and other soft tissue of lower limb, including hip
25.6
11.2
15
6
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.4
10.9
39
119
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
10.5
174
1067
ACB15
NOMESCO Finland
Excision of local lesion of tibial nerve
111.9
10.4
11
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.4
10.0
72
321
D33.30
ICD-10 Finland
Acoustic neuroma
13.7
9.7
16
12
XW3AT
NOMESCO Finland
Biopsy of other superficial organ with ultrasound guidance
13.7
9.7
16
12
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
9.4
239
1654
Q85.01
ICD-10 Finland
Neurofibromatosis, type 2
+∞
9.4
9
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.7
9.2
49
189
D17.2
ICD-10 Finland
Benign lipomatous neoplasm of skin and subcutaneous tissue of limbs
4.1
8.7
24
61
2312
FHL
Extirpation or destruction
+∞
8.3
8
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.5
8.2
55
237
SXC05
NOMESCO Finland
Other oral or dental procedure
2.6
8.1
46
183
NK1AT
NOMESCO Finland
Muscle biopsy with ultrasound guidance
22.4
8.0
11
5
N02BF01
ATC
gabapentin; oral
2.1
8.0
78
394
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
7.9
223
1570
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
15.3
7.7
12
8
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
15.3
7.7
12
8
D33.9
ICD-10 Finland
Benign neoplasm: Central nervous system, unspecified
45.6
7.7
9
*
ZXA05
NOMESCO Finland
Left side
1.7
7.7
159
1029
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
7.6
103
586
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.9
7.6
102
579
S18
ICPC
Laceration/cut
1.6
7.6
300
2291
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.4
7.5
27
83
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.1
7.3
77
401
9560/0-C72.0
ICD-O-3
Schwannoma, NOS, of spinal cord
+∞
7.3
7
*
ACB13
NOMESCO Finland
Excision of local lesion of ulnar nerve
+∞
7.3
7
*
ACB18
NOMESCO Finland
Excision of local lesion of brachial plexus
+∞
7.3
7
*
L17
ICPC
Foot/toe symptom/complaint
1.6
7.1
197
1374
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.2
7.1
62
300
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.3
7.0
54
249
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
3.6
6.9
22
62
D31.6
ICD-10 Finland
Benign neoplasm: Orbit, unspecified
22.8
6.7
9
*
WX402
NOMESCO Finland
General anaesthesia
1.7
6.6
138
891
9736
FHL
Subcutaneous tumor removal in operating room or anesthesia
7.9
6.6
14
18
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
6.5
430
3645
R13
ICD-10 Finland
Dysphagia
2.2
6.5
53
250
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
3.8
6.4
19
51
ABB10
NOMESCO Finland
Resection of lesion of spinal canal
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
313
2157
1.92
13.95
2.4
2.2
—
—
—
0
0
136
729
2.11
12.23
1.5
1.3
—
—
—
0
0
100
479
2.30
11.86
1.4
1.5
—
—
—
0
0
332
2534
1.67
8.90
2.8
2.8
—
—
estimate
—
0
0
238
1774
1.56
6.36
2.4
2.4
—
—
—
0
0
107
654
1.77
6.23
9.2
9.6
7.41
7.42
ph
0.61
60
370
320
2563
1.52
6.04
7.3
6.8
1.21
1.21
mmol/l
0.36
305
2363
383
3200
1.52
5.82
9.3
10.0
4.04
4.10
e9/l
0.18
328
2797
186
1337
1.56
5.72
2.3
2.4
—
—
—
0
0
104
649
1.73
5.61
9.3
9.6
1.25
0.96
mmol/l
0.35
84
542
386
3258
1.50
5.38
6.3
5.4
6.58
6.71
mmol/l
0.71
377
3104
341
2821
1.47
5.16
7.3
7.7
1.21
1.21
mmol/l
0.52
305
2452
345
2875
1.46
4.93
6.0
6.4
0.04
0.04
e9/l
0.03
293
2479
59
323
1.91
4.88
2.9
3.7
4.25
4.60
pmol/l
1.89
51
289
343
2866
1.44
4.77
6.1
6.4
0.56
0.58
e9/l
0.99
290
2466
351
2958
1.43
4.58
6.3
6.7
0.19
0.19
e9/l
0.14
306
2584
151
1089
1.51
4.44
1.4
1.3
33.34
35.05
iu/ml
0.05
45
347
346
2921
1.42
4.39
6.1
6.5
1.81
1.95
e9/l
1.27
297
2582
313
2600
1.42
4.33
14.0
13.7
1.21
1.23
inr
0.30
255
2159
224
1770
1.42
4.05
2.4
2.2
145.46
184.64
u/l
1.30
214
1692
18
64
2.87
3.99
2.3
1.3
—
—
nmol/l
—
0
0
241
1936
1.40
3.94
3.5
3.6
2.36
2.36
mmol/l
0.26
221
1757
286
2372
1.38
3.84
3.6
3.5
6.31
6.19
ph
0.84
143
1339
136
990
1.48
3.77
1.4
1.3
9.60
13.92
u/ml
0.29
53
383
571
5388
1.84
3.76
22.4
19.3
139.84
139.66
mmol/l
1.01
562
5290
571
5395
1.82
3.64
22.3
19.5
3.95
3.97
mmol/l
1.05
561
5286
208
1657
1.39
3.48
5.7
6.4
—
—
—
0
0
172
1330
1.41
3.43
4.1
3.8
—
0.19
—
0
16
78
517
1.58
3.32
8.0
8.7
1.12
1.34
mmol/l
1.91
78
505
74
485
1.60
3.31
8.0
9.9
—
—
—
0
0
216
1753
1.36
3.17
4.0
4.1
7.40
7.40
ph
0.31
150
1250
460
4185
1.39
3.16
4.8
4.4
14.72
14.84
pmol/l
0.49
430
3837
291
2474
1.33
3.12
5.0
5.1
35.66
35.74
g/l
0.08
271
2323
30
153
2.01
3.10
1.6
1.3
8.24
9.68
u/l
0.26
24
124
115
841
1.45
3.09
2.0
2.1
—
—
—
0
0
338
2941
1.33
3.07
4.2
3.9
0.00
0.00
estimate
0.50
58
607
340
2972
1.32
2.94
4.2
4.0
0.00
4.84
estimate
0.80
57
626
60
385
1.62
2.94
2.7
2.6
11.36
17.12
au/ml
0.60
12
34
341
2983
1.32
2.92
6.8
6.7
11.29
11.63
umol/l
0.21
323
2856
18
76
2.41
2.92
2.3
1.3
0.46
25.20
nmol/l
0.50
18
69
307
2649
1.32
2.89
6.3
6.7
8.85
8.87
%
0.04
287
2488
69
463
1.55
2.81
2.2
2.6
7.29
7.88
ug/l
0.10
61
416
554
5254
1.55
2.71
18.4
16.4
24.71
24.28
mg/l
0.11
465
4359
305
2646
1.30
2.70
6.0
6.5
2.91
2.83
%
0.25
285
2480
524
4920
1.44
2.64
5.9
5.5
1.89
1.92
mu/l
0.27
490
4545
310
2701
1.30
2.63
6.3
6.6
28.09
27.54
%
0.33
291
2560
339
2995
1.29
2.56
4.3
4.0
0.00
0.55
estimate
0.54
55
581
305
2658
1.29
2.56
6.2
6.5
56.30
57.43
%
0.88
291
2536
578
5549
1.69
2.52
13.3
12.4
25.07
26.26
u/l
1.25
565
5410
184
1501
1.32
2.52
1.4
1.4
—
—
—
0
0
303
2644
1.29
2.50
6.1
6.6
0.71
0.69
%
0.22
284
2475
122
940
1.37
2.43
1.8
1.7
1105.26
1199.40
nmol/l
0.59
89
706
206
1715
1.30
2.42
3.3
3.3
—
—
—
0
0
124
959
1.37
2.41
4.0
3.6
0.82
0.81
mmol/l
0.27
118
906
580
5581
1.69
2.40
24.6
21.4
77.70
77.08
umol/l
0.15
574
5527
40
245
1.68
2.37
1.5
1.3
27.31
25.80
iu/l
0.09
29
214
100
754
1.39
2.27
3.8
5.8
1.03
1.02
mmol/l
0.12
93
695
53
354
1.54
2.23
9.7
11.4
24.78
24.42
mmol/l
0.40
53
349
55
378
1.50
2.05
1.2
1.2
—
—
—
0
0
392
3581
1.26
2.04
5.4
4.8
825.67
2469.28
e6/l
—
6
61
530
5040
1.37
1.99
6.3
6.6
38.57
39.48
mmol/mol
1.91
491
4748
133
1072
1.31
1.95
4.9
4.0
228.85
288.87
ng/l
0.21
101
850
78
581
1.39
1.92
4.3
4.2
5.82
31.24
ug/l
1.09
60
482
62
445
1.44
1.88
1.2
1.2
—
—
—
0
0
8
28
2.88
1.86
1.3
1.2
162.13
175.13
mmol/24h
—
8
28
158
1311
1.28
1.85
1.3
1.3
1.35
1.28
u/ml
0.05
35
367
186
1575
1.26
1.84
4.1
4.3
—
—
—
0
0
537
5130
1.37
1.84
5.3
5.3
5.93
5.99
mmol/l
0.34
494
4726
12
53
2.29
1.81
4.4
2.1
13.57
13.08
%
0.54
12
53
218
1885
1.24
1.79
6.2
6.2
—
—
—
0
0
560
5395
1.42
1.74
16.3
14.5
—
—
—
0
0
57
409
1.43
1.74
3.3
3.3
137.94
178.44
ng/l
0.62
50
378
586
5699
1.60
1.70
28.9
24.9
252.50
249.57
e9/l
0.53
575
5603
586
5700
1.60
1.69
28.9
24.8
90.67
91.16
fl
2.08
579
5650
586
5701
1.59
1.67
29.7
25.4
40.61
40.39
%
0.61
579
5647
586
5701
1.59
1.67
28.9
24.8
4.52
4.49
e12/l
0.83
573
5588
586
5701
1.59
1.67
28.9
24.8
30.15
30.34
pg
2.14
579
5651
153
1280
1.26
1.67
5.5
5.0
—
—
—
0
0
41
278
1.51
1.66
2.5
2.4
—
—
—
0
0
107
856
1.30
1.66
2.5
2.1
29.38
29.48
s
0.06
107
838
586
5702
1.59
1.66
29.0
24.9
6.48
6.71
e9/l
2.05
573
5589
450
4220
1.25
1.65
9.2
8.4
77.04
79.71
u/l
0.47
434
4004
73
553
1.36
1.64
2.5
1.9
362.96
380.10
nmol/l
0.31
67
524
186
2146
0.81
1.63
2.8
3.2
—
—
—
0
0
586
5704
1.58
1.63
29.2
25.0
135.12
135.31
g/l
0.12
580
5650
12
56
2.17
1.62
4.2
3.2
1.91
6.50
nmol/l
0.94
12
56
173
1477
1.24
1.57
2.3
2.8
328.86
344.76
umol/l
1.28
157
1316
284
2552
1.21
1.56
3.2
3.0
118.62
123.65
ug/l
0.13
262
2377
174
1491
1.23
1.53
3.1
3.2
—
0.00
estimate
—
0
6
82
641
1.32
1.51
2.0
2.8
1.68
1.84
%
1.34
71
581
100
804
1.29
1.50
1.2
1.3
—
—
—
0
0
15
79
1.92
1.50
2.2
1.3
0.27
0.30
nmol/l
—
10
64
12
58
2.09
1.50
1.5
1.3
—
—
—
0
0
237
2102
1.21
1.47
3.8
4.1
31.84
120.09
e6/l
3.16
170
1500
83
653
1.31
1.47
2.3
2.9
9.19
8.41
umol/l
0.10
74
585
11
52
2.14
1.45
1.1
1.4
14.52
30.83
ng/l
1.50
11
52
12
59
2.05
1.44
1.3
1.2
—
—
—
0
0
206
1807
1.21
1.43
3.0
2.7
66.99
65.33
u/l
0.05
191
1668
6
139
0.43
1.41
2.0
4.3
—
—
—
0
0
166
1432
1.22
1.36
2.8
2.3
2.93
2.93
mg/l
0.00
142
1240
250
2242
1.19
1.35
4.3
3.8
0.00
0.04
estimate
2.27
48
514
150
1281
1.23
1.35
2.0
1.8
1.30
1.28
mg/l
0.03
120
1005
31
208
1.52
1.35
1.2
1.3
—
—
—
0
0
35
242
1.47
1.33
1.3
1.2
—
—
—
0
0
86
690
1.29
1.33
1.2
1.3
—
—
—
0
0
28
185
1.54
1.31
9.8
4.2
1.17
1.39
mmol/l
1.17
28
180
189
1657
1.20
1.30
5.1
4.1
0.00
0.01
estimate
0.74
54
580
14
76
1.86
1.30
3.0
1.3
26.42
74.82
mu/l
0.74
14
71
89
719
1.28
1.30
1.9
2.4
150.10
119.70
ug/g
0.23
71
557
40
286
1.43
1.29
1.0
1.1
—
—
—
0
0
24
154
1.58
1.27
2.4
3.5
1.40
1.74
index
—
10
93
20
124
1.63
1.22
1.4
1.3
466.64
1030.44
e6/l
0.26
14
97
8
37
2.18
1.21
1.0
1.1
—
—
—
0
0
58
448
1.33
1.19
2.2
3.8
66.97
84.24
ng/l
1.50
51
392
275
2508
1.17
1.19
2.4
2.5
77.82
77.26
nmol/l
0.11
247
2259
179
1575
1.19
1.18
3.2
3.3
0.69
0.45
e6/l
0.57
135
1168
67
530
1.30
1.17
2.9
2.5
33.35
35.23
u/l
0.16
52
446
111
935
1.23
1.15
2.3
2.5
15.02
13.02
umol/l
1.93
98
872
98
815
1.24
1.14
1.3
1.4
581.33
528.77
titre
0.06
15
187
63
496
1.30
1.14
1.9
3.0
64.66
72.03
e9/l
1.41
44
364
243
2202
1.17
1.13
3.9
3.9
19.96
60.90
ng/l
0.97
160
1589
13
73
1.80
1.11
1.6
1.3
383.23
332.18
pmol/l
0.34
13
65
150
1310
1.19
1.07
4.7
4.0
1.02
1.02
kg/l
0.17
96
881
541
5248
1.26
1.06
5.3
5.3
4.72
4.64
mmol/l
1.12
507
4899
80
656
1.25
1.06
1.5
1.7
—
—
—
0
0
187
1669
1.17
1.04
1.7
1.7
19.98
20.61
nmol/l
0.23
155
1407
19
122
1.58
1.03
1.4
1.2
1.62
11.83
e6/l
1.00
13
92
10
53
1.90
1.01
1.7
1.2
—
—
—
0
0
10
54
1.87
0.97
1.1
1.1
—
—
—
0
0
213
1931
1.16
0.96
3.2
3.7
—
0.67
—
0
6
134
1171
1.18
0.95
1.3
1.5
2.11
2.50
g/l
1.92
75
718
253
2324
1.15
0.95
2.0
2.0
1.27
1.36
mmol/l
1.19
212
1947
67
546
1.25
0.95
2.2
2.2
0.00
0.03
estimate
—
8
116
6
119
0.50
0.94
1.0
1.1
—
—
—
0
0
177
1587
1.16
0.92
2.5
3.0
—
0.06
—
0
35
17
110
1.56
0.91
1.8
1.4
—
—
—
0
0
38
289
1.34
0.90
2.3
2.3
0.00
0.01
estimate
—
8
89
130
1139
1.18
0.90
3.3
2.8
2.45
2.45
mmol/l
0.02
118
1023
48
378
1.29
0.90
1.3
1.7
1.81
1.39
g/l
0.39
39
346
6
29
2.08
0.89
1.7
1.8
—
—
—
0
0
547
5331
1.24
0.89
6.1
5.9
2.76
2.71
mmol/l
0.79
505
4959
59
478
1.26
0.89
3.0
2.3
12.85
13.72
nmol/l
0.35
52
438
6
31
1.94
0.84
1.0
1.1
—
—
—
0
0
384
3648
1.14
0.84
3.3
3.4
43.67
50.30
u/l
0.90
363
3439
22
155
1.43
0.82
1.1
1.1
3.24
10.07
eliau/ml
—
5
21
22
155
1.43
0.82
1.2
1.3
—
—
—
0
0
17
114
1.51
0.80
1.2
1.4
—
—
—
0
0
9
148
0.60
0.80
1.8
1.6
—
—
—
0
0
16
106
1.52
0.79
1.4
1.3
—
—
—
0
0
16
106
1.52
0.79
1.2
1.4
95.67
171.25
au/ml
—
6
34
6
33
1.83
0.79
1.2
1.7
—
—
—
0
0
85
727
1.20
0.78
2.4
3.3
4.12
5.18
e9/l
0.72
73
634
144
1287
1.16
0.78
2.9
2.7
6.96
5.45
e6/l
0.62
125
1192
67
562
1.22
0.76
1.9
2.3
0.21
0.21
g/l
0.22
62
526
9
53
1.71
0.75
1.0
1.1
—
—
—
0
0
44
543
0.80
0.74
1.4
1.5
—
—
—
0
0
5
25
2.01
0.73
1.2
3.4
4791.00
713.88
u/ml
—
5
25
5
25
2.01
0.73
1.0
1.2
147.78
181.11
iu/ml
—
5
25
200
1838
1.13
0.72
3.4
3.4
17.95
97.94
e6/l
1.52
156
1433
32
249
1.30
0.68
1.9
2.0
—
—
—
0
0
17
119
1.44
0.67
3.7
2.9
—
—
—
0
0
22
162
1.37
0.67
2.9
1.9
197.91
222.18
pmol/l
0.57
22
153
7
43
1.63
0.67
1.3
1.8
37.31
37.60
%
—
7
43
18
128
1.42
0.66
1.1
1.2
3.75
3.78
mmol/l
0.05
18
119
207
1917
1.12
0.65
3.6
3.4
32.07
32.66
u/l
0.05
190
1811
10
62
1.62
0.65
2.8
2.7
—
—
—
0
0
55
462
1.21
0.63
2.1
2.6
9.91
10.77
g/l
1.10
50
424
58
490
1.20
0.63
2.5
3.2
66.07
67.08
g/l
0.50
52
447
67
575
1.19
0.62
2.8
3.3
6.06
5.79
kpa
1.50
67
557
5
30
1.67
0.61
1.0
1.1
0.45
0.51
ratio
—
5
17
8
50
1.61
0.61
1.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.6
—
—
—
0
0
264
2493
1.10
0.57
10.9
11.7
0.00
0.00
e9/l
0.31
205
2054
13
183
0.70
0.56
1.5
1.5
—
—
—
0
0
19
142
1.35
0.55
1.3
1.3
545.74
465.36
mg/l
0.62
19
132
48
405
1.20
0.55
2.8
2.7
—
—
—
0
0
60
518
1.18
0.53
3.6
4.3
7.37
7.35
ph
1.00
40
376
186
1732
1.11
0.53
3.4
3.3
741.87
1158.26
ng/l
2.07
158
1476
533
5228
1.15
0.53
5.2
5.1
1.52
1.47
mmol/l
1.95
496
4847
9
63
1.43
0.52
1.8
2.4
—
—
—
0
0
9
63
1.43
0.52
1.3
1.3
—
—
—
0
0
6
98
0.61
0.52
1.3
1.6
—
—
—
0
0
12
83
1.45
0.52
1.2
1.1
2.43
2.34
eliau/ml
—
6
34
11
75
1.48
0.51
2.9
2.1
10.55
10.79
mmol/l
0.07
11
75
21
162
1.31
0.50
1.0
1.2
—
—
—
0
0
7
106
0.66
0.49
1.0
1.1
—
—
—
0
0
511
5006
1.12
0.48
4.3
4.4
1.23
1.29
mmol/l
1.65
476
4608
262
2491
1.09
0.48
2.3
2.1
98.09
97.32
pmol/l
0.10
134
1300
90
811
1.13
0.46
2.4
2.5
25.56
22.29
%
1.36
81
758
19
147
1.30
0.45
1.2
2.1
3.54
4.25
iu/l
—
6
61
96
870
1.12
0.45
2.4
2.5
2.36
2.32
g/l
0.31
86
806
14
186
0.75
0.45
1.5
1.5
—
—
—
0
0
19
148
1.29
0.44
1.0
1.2
—
—
—
0
0
65
576
1.14
0.43
2.8
3.5
7.36
7.39
ph
1.48
29
335
5
31
1.62
0.43
2.0
2.4
—
—
—
0
0
124
1145
1.10
0.42
1.6
1.7
450.59
23745206.39
pmol/l
0.97
103
956
23
185
1.25
0.42
1.5
1.4
220.71
312.08
ug/g
1.33
15
107
14
184
0.76
0.42
1.5
1.5
—
—
—
0
0
14
184
0.76
0.42
1.5
1.5
—
—
—
0
0
8
57
1.41
0.42
3.9
2.2
—
—
—
0
0
13
96
1.36
0.42
2.8
1.7
—
—
—
0
0
8
58
1.38
0.41
1.1
1.1
—
—
—
0
0
206
1950
1.08
0.41
3.1
3.4
7.60
7.60
mmol/l
0.00
178
1644
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
65
579
1.14
0.41
1.8
1.5
—
—
—
0
0
22
177
1.25
0.41
8.1
10.5
—
—
—
0
0
0
17
0.00
0.40
0.0
1.5
—
8.62
—
0
17
0
17
0.00
0.40
0.0
1.0
—
11.93
—
0
12
98
898
1.11
0.39
2.9
3.1
5.04
2.41
e6/l
0.59
48
444
21
258
0.81
0.39
3.0
3.3
25.55
25.21
mmol/l
0.31
21
250
179
1690
1.08
0.38
5.9
5.3
2.15
2.38
ug/l
0.33
169
1525
5
36
1.39
0.38
1.0
1.1
253.00
227.58
mg/l
—
5
31
39
449
0.86
0.37
2.8
2.5
6.09
6.12
ph
0.07
22
300
9
70
1.29
0.36
1.2
1.3
—
—
—
0
0
6
89
0.67
0.33
2.0
1.7
—
—
—
0
0
198
1891
1.07
0.31
3.7
4.2
4.65
9.05
mg/mmol
1.16
121
1171
7
53
1.32
0.31
1.0
1.2
—
—
—
0
0
7
55
1.28
0.30
2.7
2.7
—
—
—
0
0
7
55
1.28
0.30
2.9
1.7
12.27
11.35
%
—
7
55
46
512
0.89
0.29
5.6
5.2
0.00
0.18
%
1.55
13
132
193
1848
1.06
0.28
3.2
3.5
25.48
50.74
mg/l
2.13
119
1178
14
172
0.81
0.27
1.5
1.5
—
—
—
0
0
11
86
1.28
0.26
1.9
1.5
—
—
—
0
0
11
86
1.28
0.26
1.9
1.5
—
—
—
0
0
11
86
1.28
0.26
1.9
1.5
—
—
—
0
0
11
86
1.28
0.26
1.9
1.5
—
—
—
0
0
9
77
1.17
0.24
1.2
1.2
—
—
—
0
0
22
190
1.16
0.23
3.2
3.6
18.70
2.75
ratio
0.62
12
108
22
190
1.16
0.23
1.3
1.2
0.87
0.91
g/l
0.46
22
190
5
38
1.32
0.23
1.2
1.1
35.80
44.27
mg/l
—
5
31
5
38
1.32
0.23
1.0
1.2
—
—
—
0
0
16
134
1.20
0.23
1.3
1.2
—
—
—
0
0
17
200
0.85
0.23
1.3
1.4
1.10
1.20
g/l
0.59
17
191
5
40
1.25
0.22
1.0
1.3
—
—
—
0
0
5
40
1.25
0.22
1.2
1.7
1965.80
1086.57
e6/l
—
5
35
14
167
0.83
0.22
1.1
1.1
—
—
—
0
0
10
124
0.80
0.21
2.1
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
61.09
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
7298.60
—
0
10
0
10
0.00
0.21
0.0
2.2
—
17.23
—
0
10
0
10
0.00
0.21
0.0
1.0
—
0.02
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
39.32
—
0
13
0
14
0.00
0.20
0.0
3.4
—
—
—
0
0
16
136
1.18
0.20
1.5
1.8
—
—
—
0
0
22
250
0.88
0.20
1.1
1.5
0.31
0.34
mg/l
—
8
109
46
423
1.09
0.20
1.5
1.5
—
—
—
0
0
41
375
1.10
0.20
5.6
3.7
7.42
7.42
ph
0.13
34
315
42
457
0.91
0.19
3.8
4.1
1.23
1.23
mmol/l
0.10
33
400
6
51
1.18
0.19
1.0
1.4
5.88
6.50
g/l
—
6
40
6
51
1.18
0.19
1.0
1.4
0.23
0.36
g/l
—
6
39
48
444
1.09
0.19
5.5
3.9
—
—
—
0
0
168
1625
1.05
0.18
3.4
3.4
0.00
0.06
estimate
0.60
47
509
7
62
1.13
0.17
1.0
1.1
—
—
—
0
0
97
926
1.06
0.17
1.6
1.9
—
—
—
0
0
8
68
1.18
0.16
2.0
1.8
—
—
—
0
0
33
360
0.91
0.16
1.2
1.2
143.84
106.55
u/ml
0.27
17
150
60
637
0.94
0.16
1.5
1.7
—
—
—
0
0
27
245
1.11
0.15
1.3
1.9
6.93
9.99
iu/ml
—
7
59
9
79
1.14
0.15
1.4
1.4
38.64
31.54
g/l
—
9
70
46
431
1.07
0.14
1.4
1.7
—
—
—
0
0
53
500
1.07
0.14
1.3
1.4
—
—
—
0
0
19
170
1.12
0.13
1.1
2.3
12.91
12.23
mg/l
0.21
19
158
10
116
0.86
0.12
1.4
3.1
9.25
8.52
pmol/l
—
10
116
11
95
1.16
0.11
1.1
1.1
0.54
2.82
u/ml
—
5
49
20
218
0.91
0.10
1.0
1.1
—
—
—
0
0
20
183
1.10
0.10
1.3
1.1
1.51
1.54
g/l
0.19
20
183
56
538
1.04
0.08
5.4
4.7
0.65
0.94
%
0.90
23
181
5
60
0.83
0.08
1.6
1.4
—
—
—
0
0
5
63
0.79
0.08
1.2
1.7
—
—
—
0
0
5
65
0.77
0.08
1.0
1.2
—
—
—
0
0
6
70
0.86
0.07
1.3
1.2
—
—
—
0
0
6
74
0.81
0.07
1.3
1.3
—
116.66
—
0
5
8
78
1.03
0.07
1.7
1.3
—
—
—
0
0
7
81
0.86
0.07
1.1
1.2
—
—
—
0
0
9
84
1.07
0.07
2.2
2.7
—
—
—
0
0
11
122
0.90
0.07
2.9
2.9
55.91
57.38
%
0.11
11
122
9
87
1.03
0.07
2.7
3.1
3.49
4.36
e9/l
—
9
87
9
100
0.90
0.06
2.2
1.8
—
—
—
0
0
9
102
0.88
0.06
1.0
1.1
—
—
—
0
0
9
102
0.88
0.06
1.0
1.1
—
—
—
0
0
49
507
0.96
0.06
5.3
4.9
0.06
0.11
%
0.28
16
149
18
192
0.94
0.05
1.3
1.4
0.22
0.24
g/l
0.36
18
184
49
505
0.97
0.05
5.1
4.7
0.38
0.54
%
0.45
16
162
108
1096
0.98
0.04
2.6
2.9
503.74
530.64
mosm/kgh2o
0.77
89
969
19
180
1.06
0.04
1.3
1.4
—
—
—
0
0
13
139
0.93
0.03
1.9
2.6
362.06
66.62
ug/min
—
7
84
73
718
1.02
0.03
1.6
1.5
—
—
—
0
0
79
778
1.02
0.03
1.4
1.6
—
—
—
0
0
60
589
1.02
0.03
1.6
1.6
—
—
—
0
0
40
410
0.97
0.02
1.7
1.8
3.54
3.45
mmol/l
0.21
28
300
24
249
0.96
0.02
3.3
1.9
1.99
2.67
ug/l
0.15
24
223
11
103
1.07
0.02
1.0
1.1
—
—
—
0
0
32
312
1.03
0.02
1.1
1.3
—
—
—
0
0
12
113
1.06
0.02
1.2
1.3
85.71
59.51
mmol/l
—
7
97
26
267
0.97
0.01
6.7
3.9
—
—
—
0
0
51
503
1.02
0.01
2.4
2.5
0.46
0.57
e6/l
0.18
45
479
17
164
1.04
0.00
1.3
1.4
159.90
216.99
miu/ml
—
10
76
22
214
1.03
0.00
2.4
2.9
—
—
—
0
0
17
165
1.03
0.00
2.2
1.6
10955.42
14316.90
e6/l
0.17
12
119
25
245
1.02
0.00
2.1
1.8
—
—
—
0
0
102
1025
0.99
0.00
3.8
3.1
0.72
0.74
ug/l
0.13
77
636
12
119
1.01
0.00
1.1
1.3
243.99
280.82
u/ml
—
7
65
5
57
0.88
0.00
1.8
2.5
—
21.62
—
0
5
5
51
0.98
0.00
1.0
1.4
2.43
2.75
g/l
—
5
39
5
53
0.94
0.00
1.0
1.4
—
—
—
0
0
7
71
0.99
-0.00
1.0
1.0
—
3.08
—
0
29
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
179.80
—
0
5
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
59
0.85
-0.00
1.2
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
2.37
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
-0.00
1.2
1.1
—
—
—
0
0
6
66
0.91
-0.00
1.3
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
0.45
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
17.87
—
0
7
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
61
0.98
-0.00
2.0
2.7
—
—
—
0
0
6
63
0.95
-0.00
1.3
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.2
—
7.22
—
0
9
5
54
0.93
-0.00
2.2
2.7
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_PERIPH_AUTO_NEURO and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_PERIPH_AUTO_NEURO 1.074 [0.83, 1.39] 0.589
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 883 females with CD2_BENIGN_PERIPH_AUTO_NEURO died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_PERIPH_AUTO_NEURO 1.103 [0.85, 1.43] 0.46
Birth year 0.985 [0.97, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 763 males with CD2_BENIGN_PERIPH_AUTO_NEURO died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_PERIPH_AUTO_NEURO.

N-year risk Females Males
1 0.081% 0.203%
5 0.509% 1.092%
10 1.267% 2.805%
15 2.412% 5.409%
20 3.959% 9.269%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_PERIPH_AUTO_NEURO – Benign neoplasm: Peripheral nerves and autonomic nervous system

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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