Brain glioblastoma and astrocytoma

C3_GBM_ASTROCYTOMA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

  • HLP_C3_GBM
  • or HLP_C3_ASTROCYTOMA
766

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C71
  • Cause of death: ICD-9 191
  • Cause of death: ICD-8 191
  • Cancer registry: Topography ICD-O-3 C71
  • Cancer registry: Morphology ICD-O-3 9400|9440
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

766

4. Check minimum number of events

None

766

5. Include endpoints

766

6. Filter based on genotype QC (FinnGen only)

679

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF9

Similar endpoints

List of similar endpoints to Brain glioblastoma and astrocytoma based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 679 286 393
Unadjusted period prevalence (%) 0.15 0.10 0.18
Median age at first event (years) 62.61 61.74 63.24

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
716
Matched controls
7160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
37.1
310.1
204
76
ZXC95
NOMESCO Finland
Use of surgical navigator
101.3
307.7
193
26
A04AA01
ATC
ondansetron; systemic, rectal
52.7
307.7
233
65
N03AX14
ATC
levetiracetam; systemic
135.4
307.7
407
69
A03FA01
ATC
metoclopramide; systemic, rectal
26.7
307.7
468
472
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
50.9
307.7
394
168
WF002
NOMESCO Finland
Radical radiotherapy
1082.8
307.7
311
5
A04AA02
ATC
granisetron; systemic, transdermal
2751.1
307.7
312
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
2740.6
307.7
530
7
130
Kela drug reimbursment
Malignant tumour
+∞
307.7
568
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
82.6
307.7
300
62
XX3DW
NOMESCO Finland
Time consuming IT work
27.7
307.7
255
140
H02AB02
ATC
dexamethasone; systemic
1281.9
307.7
610
32
L01AX03
ATC
temozolomide; systemic
+∞
307.7
505
*
Z51.5
ICD-10 Finland
Palliative care
54.2
307.7
336
115
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
43.4
307.7
447
264
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
638.2
295.1
273
7
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
41.8
271.7
170
53
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
233.5
211
*
C71.23
ICD-10 Finland
Malignant tumor of temporal lobe grade IV glioma
+∞
232.3
210
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
31.6
225.0
153
61
C71.2
ICD-10 Finland
Malignant neoplasm: Temporal lobe
+∞
214.7
195
*
N03AX18
ATC
lacosamide; systemic
76.7
214.5
116
18
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
794.8
191.4
180
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
188.0
172
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
2367.5
187.0
173
*
C71.13
ICD-10 Finland
Malignant tumor of frontal lobe grade IV glioma
+∞
184.6
169
*
9440/3-C71.9
ICD-O-3
Glioblastoma, NOS, of brain, NOS
+∞
178.9
164
*
C71.10
ICD-10 Finland
Malignant tumor in frontal lobe without histology
+∞
177.7
163
*
C71.1
ICD-10 Finland
Malignant neoplasm: Frontal lobe
+∞
177.7
163
*
C71.20
ICD-10 Finland
Malignant tumor in temporal lobe without histology
+∞
172.0
158
*
N03AF02
ATC
oxcarbazepine; oral
18.2
164.2
141
95
AA1AD
NOMESCO Finland
CT of head and brain
7.4
157.9
465
1427
9440/3-C71.2
ICD-O-3
Glioblastoma, NOS, of temporal lobe
+∞
156.1
144
*
C71.90
ICD-10 Finland
Malignant tumor in unspecified localization in the brain without histology
+∞
149.3
138
*
WX882
NOMESCO Finland
High dependency care
22.7
147.2
112
58
ZXC40
NOMESCO Finland
Use of ultrasound
83.7
140.8
75
10
AAG00
NOMESCO Finland
Stereotactic intracranial biopsy
+∞
132.5
123
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
10.2
123.2
156
191
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
246.9
123.0
123
6
9440/3-C71.1
ICD-O-3
Glioblastoma, NOS, of frontal lobe
+∞
119.2
111
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
1309.6
117.2
111
*
N05CD08
ATC
midazolam; nasal, systemic
17.4
112.2
96
63
C71.33
ICD-10 Finland
Malignant tumor of parietal lobe grade IV glioma
+∞
104.8
98
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
5.7
103.6
258
640
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
6.7
103.3
201
396
N02AA05
ATC
oxycodone; systemic
5.9
100.9
234
543
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
9.3
98.5
130
166
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
536.6
96.8
94
*
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
53.0
93.7
54
11
C71.11
ICD-10 Finland
Malignant tumor of frontal lobe grade II glioma
+∞
92.8
87
*
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
38.6
91.7
57
16
ZX095
NOMESCO Finland
Combined chemoradiotherapy
+∞
89.5
84
*
C71.30
ICD-10 Finland
Malignant tumor in parietal lobe without histology
+∞
87.3
82
*
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
322.0
85.6
85
*
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
30.3
83.8
56
20
G40.9
ICD-10 Finland
Epilepsy, unspecified
9.7
83.2
104
123
C71.3
ICD-10 Finland
Malignant neoplasm: Parietal lobe
+∞
83.0
78
*
WZC00
NOMESCO Finland
Treatment plan or consultation
4.3
82.1
362
1372
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
291.2
78.1
78
*
AA1BD
NOMESCO Finland
Extensive CT of head and brain
17.2
77.9
66
42
WZC30
NOMESCO Finland
Teaching
5.0
74.4
198
506
ZX050
NOMESCO Finland
Stereotactic radiotherapy
+∞
73.2
69
*
C71.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of brain
+∞
71.0
67
*
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
199.7
70.5
72
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
196.7
69.4
71
*
N74
ICPC
Malignant neoplasm nervous system
735.8
69.2
67
*
C71.83
ICD-10 Finland
Overall malignant tumor of the brain grade IV glioma
+∞
68.9
65
*
9440/3-C71.3
ICD-O-3
Glioblastoma, NOS, of parietal lobe
+∞
67.8
64
*
XA800
NOMESCO Finland
Neuropsychological investigation
7.8
66.0
98
142
C71.21
ICD-10 Finland
Malignant tumor of temporal lobe grade II glioma
+∞
65.6
62
*
9400/3-C71.1
ICD-O-3
Astrocytoma, NOS, of frontal lobe
+∞
64.6
61
*
D43.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, unspecified
348.0
63.5
63
*
ZXM40
NOMESCO Finland
Use of fluorescent substance
663.5
62.8
61
*
WX402
NOMESCO Finland
General anaesthesia
4.0
61.9
245
833
N05BA09
ATC
clobazam; oral
28.2
58.6
40
15
N03AB02
ATC
phenytoin; systemic
16.2
57.6
50
33
C71.99
ICD-10 Finland
Malignant tumor in unspecified localization in the brain other or unspecified histology
+∞
57.0
54
*
9400/3-C71.9
ICD-O-3
Astrocytoma, NOS, of brain, NOS
+∞
56.0
53
*
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
17.5
55.2
46
28
JN4AD
NOMESCO Finland
Body CT examination
6.0
53.1
103
196
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
23.5
52.1
38
17
WX872
NOMESCO Finland
Intensive care
5.9
51.3
100
191
A02BC02
ATC
pantoprazole; systemic
4.2
51.3
590
3778
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
50.6
48
*
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
17.3
49.1
41
25
ZX070
NOMESCO Finland
Intensity modified radiotherapy
511.1
49.0
48
*
H53.4
ICD-10 Finland
Visual field defects
10.6
48.6
55
56
A79
ICPC
Malignancy NOS
+∞
48.5
46
*
C71.29
ICD-10 Finland
Malignant tumor in temporal lobe other or unspecified histology
+∞
48.5
46
*
R4120
NOMESCO Finland
Occupational therapy
5.5
46.7
99
204
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
18.2
46.6
38
22
A28
ICPC
Limited function/disability NOS
3.5
45.6
202
723
ZXE20
NOMESCO Finland
More than three and less than five hours
3.9
43.8
150
451
JN4BD
NOMESCO Finland
Extensive body CT
6.3
43.8
78
136
AAA10
NOMESCO Finland
Biopsy through craniotomy
+∞
43.2
41
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
8.7
42.8
56
69
C71.12
ICD-10 Finland
Malignant tumor of frontal lobe grade III glioma
+∞
42.1
40
*
XX9BW
NOMESCO Finland
Submitting image material and/or investigation material to authority or other institution
14.2
41.9
39
29
C71.80
ICD-10 Finland
Overall malignant tumor of the brain without histology
+∞
41.0
39
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
91.4
39.2
43
5
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
+∞
38.9
37
*
C71.93
ICD-10 Finland
Malignant tumor in an unspecified localization in the brain grade IV glioma
+∞
38.9
37
*
C71.22
ICD-10 Finland
Malignant tumor of temporal lobe grade III glioma
+∞
36.8
35
*
WC105
NOMESCO Finland
Simple cytostatic therapy of local tumor recidive
+∞
36.8
35
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
14.2
36.7
34
25
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
35.7
221
947
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.0
34.7
192
772
C71.43
ICD-10 Finland
Malignant tumor of the occipital lobe grade IV glioma
+∞
34.7
33
*
C71.19
ICD-10 Finland
Malignant tumor of frontal lobe other or unspecified histology
+∞
34.7
33
*
G40.10
ICD-10 Finland
Simple partial seizures
44.6
34.4
42
10
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
126.2
34.0
36
*
A98
ICPC
Health maint/preventive medicine
0.3
33.9
540
6478
WF029
NOMESCO Finland
Radiotherapy of local residive tumor
+∞
33.6
32
*
N76
ICPC
Neoplasm nervous system unspecified
+∞
33.6
32
*
C71.9
ICD-10 Finland
Malignant neoplasm: Brain, unspecified
+∞
32.5
31
*
R4110
NOMESCO Finland
Physiotherapy
2.7
32.2
242
1139
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.0
32.1
173
682
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
9.3
31.8
39
44
N05CF01
ATC
zopiclone; oral
2.6
31.6
290
1501
C71.00
ICD-10 Finland
Malignant tumor of the cerebrum except lobes and ventricles without histology
+∞
31.5
30
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
8.5
31.0
41
51
9400/3-C71.2
ICD-O-3
Astrocytoma, NOS, of temporal lobe
+∞
30.4
29
*
C71.40
ICD-10 Finland
Malignant tumor of the occipital lobe without histology
+∞
30.4
29
*
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
156.3
28.9
30
*
H02AB04
ATC
methylprednisolone; systemic
3.0
28.1
148
573
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
27.3
26
*
R4150
NOMESCO Finland
Neuropsychological rehabilitation
11.2
27.0
29
27
R90.0
ICD-10 Finland
Intracranial space-occupying lesion
281.1
26.9
27
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
145.5
26.8
28
*
B01AB10
ATC
tinzaparin; parenteral
3.6
26.5
94
285
R47.0
ICD-10 Finland
Dysphasia and aphasia
9.8
26.3
31
33
R4130
NOMESCO Finland
Speech therapy
6.3
24.9
43
72
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
7.5
24.8
36
50
N03AG01
ATC
valproic acid; systemic, rectal
3.8
24.8
82
237
9440/3-C71.0
ICD-O-3
Glioblastoma, NOS, of cerebrum
+∞
24.1
23
*
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
0.2
24.0
37
1525
H02AB09
ATC
hydrocortisone; systemic
7.2
23.9
36
52
WX704
NOMESCO Finland
Intubation
3.6
23.3
82
247
C71.4
ICD-10 Finland
Malignant neoplasm: Occipital lobe
+∞
23.0
22
*
C71.03
ICD-10 Finland
Malignant tumor of cerebellum except lobes and ventricles grade IV glioma
+∞
23.0
22
*
C71.01
ICD-10 Finland
Malignant tumor of cerebellum except lobes and ventricles grade II glioma
+∞
22.0
21
*
C71.31
ICD-10 Finland
Malignant tumor of the parietal lobe grand II glioma
+∞
22.0
21
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
21.4
186
913
9440/3-C71.8
ICD-O-3
Glioblastoma, NOS, of overlapping lesion of brain
+∞
20.9
20
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
20.9
20
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
216.0
20.7
21
*
WW200, ,
SPAT
0.3
20.5
53
1621
115
Kela drug reimbursment
Breast cancer
+∞
19.9
19
*
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
18.4
19.7
30
17
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.7
19.4
46
103
G41.9
ICD-10 Finland
Status epilepticus, unspecified
23.3
19.2
27
12
N05BA04
ATC
oxazepam; oral
2.2
19.1
215
1171
9440/3-C71.4
ICD-O-3
Glioblastoma, NOS, of occipital lobe
+∞
18.8
18
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
97.5
17.6
19
*
G40.11
ICD-10 Finland
Simple partial epileptic seizure that develops into a complex partial seizure
32.4
17.1
22
7
N03AX23
ATC
brivaracetam; systemic
26.3
17.0
23
9
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
16.7
16
*
C71.0
ICD-10 Finland
Malignant neoplasm: Cerebrum, except lobes and ventricles
+∞
16.7
16
*
C71.32
ICD-10 Finland
Malignant tumor of parietal lobe grade III glioma
+∞
16.7
16
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
16.7
16
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.7
16.1
53
152
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
+∞
15.7
15
*
C10AA07
ATC
rosuvastatin; oral
0.4
15.5
86
1852
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.8
15.1
81
312
N03AF01
ATC
carbamazepine; oral, rectal
3.4
15.0
57
180
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
4.8
14.8
34
74
C71.39
ICD-10 Finland
Malignant tumor of parietal lobe other or unspecified histology
+∞
14.6
14
*
C71
ICD-10 Finland
Malignant neoplasm of brain
+∞
14.6
14
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.6
14.6
94
398
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
6.0
14.5
26
45
YX8AD
NOMESCO Finland
Stereotactic CT examination for dose design of radiotherapy
153.0
14.5
15
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
14.3
264
1686
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
14.3
89
370
WPA15
NOMESCO Finland
Palliative care consultation with the patient and loved ones
43.4
14.2
17
*
N05BA06
ATC
lorazepam; systemic, sublingual
3.3
14.1
55
176
EB1VA, ,
NOMESCO Finland
0.2
14.0
16
843
WX110
NOMESCO Finland
Infiltration anesthesia
1.9
14.0
513
4054
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
6.5
13.3
22
35
WPA10
NOMESCO Finland
Proactive palliative care treatment plan
40.9
13.2
16
*
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
0.5
13.1
156
2562
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
12.5
12
*
Z51.0
ICD-10 Finland
Radiotherapy session
+∞
12.5
12
*
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
+∞
12.5
12
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
12.5
12
*
G93.6
ICD-10 Finland
Cerebral oedema
+∞
12.5
12
*
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
18.4
12.1
18
10
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
12.1
123
633
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
9.5
12.1
24
26
M79.6
ICD-10 Finland
Pain in limb
0.5
12.0
138
2311
WX725
NOMESCO Finland
Noninvasive ventilation
3.1
12.0
52
178
C10AX09
ATC
ezetimibe; oral
0.3
11.7
25
887
C71.81
ICD-10 Finland
Overall malignant tumor of the brain grade II glioma
+∞
11.5
11
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
121.9
11.5
12
*
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
0.4
11.4
55
1287
M25.5
ICD-10 Finland
Pain in joint
0.4
11.4
86
1676
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
0.4
11.3
48
1193
Z73.3
ICD-10 Finland
Stress, not elsewhere classified
10.8
11.3
21
20
183
Kela drug reimbursment
Lamotrigin and topiramate
9.4
11.1
22
24
GD1AA, ,
SPAT
0.2
11.1
15
709
G41.2
ICD-10 Finland
Complex partial status epilepticus
44.0
10.9
13
*
TKC20
NOMESCO Finland
Catheterisation of bladder
2.8
10.9
58
222
XX2RW, ,
NOMESCO Finland
12.2
10.9
19
16
L02BA01
ATC
tamoxifen; oral
28.5
10.8
14
5
Z02.4
ICD-10 Finland
Examination for driving licence
0.4
10.7
76
1521
D69.5
ICD-10 Finland
Secondary thrombocytopenia
60.9
10.6
12
*
Z76.0
ICD-10 Finland
Issue of repeat prescription
0.4
10.6
59
1306
C50.99
ICD-10 Finland
Breast, unspecified
+∞
10.4
10
*
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
10.4
10
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
10.4
10
*
C71.50
ICD-10 Finland
Malignant tumor of cerebral ventricle without histology
+∞
10.4
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
10.4
234
1557
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
10.2
125
686
WZC00, ,
SPAT
0.2
10.2
14
658
B01AB05
ATC
enoxaparin; parenteral
1.8
9.9
195
1245
R93.0
ICD-10 Finland
Abnormal findings on diagnostic imaging of skull and head, not elsewhere classified
55.8
9.7
11
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.6
9.6
58
237
N19
ICPC
Speech disorder
7.3
9.6
22
31
WX892
NOMESCO Finland
Monitored bed care
2.4
9.5
66
288
A10AB05
ATC
insulin aspart; parenteral
2.4
9.5
66
288
OAB38
NOMESCO Finland
Psychosocial guidance and counselling
101.3
9.4
10
*
G40.89
ICD-10 Finland
Other epilepsy
17.8
9.4
14
8
HAB40
NOMESCO Finland
Wedge excision of mammary gland
17.8
9.4
14
8
9400/3-C71.0
ICD-O-3
Astrocytoma, NOS, of cerebrum
+∞
9.4
9
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
9.4
9
*
WB401
NOMESCO Finland
Simple antibody therapy of primary tumour
+∞
9.4
9
*
OAA41
NOMESCO Finland
Health check based on individual needs
+∞
9.4
9
*
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
4.8
9.3
21
45
SAA01
NOMESCO Finland
Simple examination of mouth
0.6
9.3
335
4217
L17
ICPC
Foot/toe symptom/complaint
0.5
9.2
82
1524
G91.1
ICD-10 Finland
Obstructive hydrocephalus
15.8
9.1
14
9
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
37.2
9.0
11
*
C07AB07
ATC
bisoprolol; oral
0.6
8.9
184
2666
WPB10
NOMESCO Finland
Making a convalescent care decision
24.4
8.9
12
5
OAB42, ,
SPAT
0.2
8.9
15
620
XA400
NOMESCO Finland
EEG
12.7
8.9
15
12
R41.0
ICD-10 Finland
Disorientation, unspecified
3.3
8.9
33
103
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
0.3
8.8
33
877
JN4CD
NOMESCO Finland
Very extensive body CT
7.3
8.8
20
28
SPAT1109
SPAT
Analgesia with portable analgesic pump
50.6
8.7
10
*
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.2
8.6
34
110
I25.1
ICD-10 Finland
Atherosclerotic heart disease
0.4
8.6
52
1121
L03
ICPC
Low back symptom/complaint
0.5
8.5
77
1430
SAA02
NOMESCO Finland
Basic examination of mouth
0.6
8.4
294
3773
ZXH01
NOMESCO Finland
Procedure performed within operation theatre
91.1
8.4
9
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
91.1
8.4
9
*
L03AA02
ATC
filgrastim; parenteral
91.1
8.4
9
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.1
8.4
86
442
C71.82
ICD-10 Finland
Overall malignant tumor of the brain grade III glioma
+∞
8.3
8
*
AA5FG
NOMESCO Finland
Functional MRI examination of brain with high intensity magnet
+∞
8.3
8
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
8.3
8
*
C71.02
ICD-10 Finland
Malignant tumor of the cerebrum except lobes and ventricles grade III glioma
+∞
8.3
8
*
C71.91
ICD-10 Finland
Malignant tumor in unspecified location in the brain grade II glioma
+∞
8.3
8
*
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
+∞
8.3
8
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
0.5
8.3
67
1294
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
2.9
8.2
38
135
R83
ICPC
Respiratory infection other
0.4
8.2
57
1165
PA6AD
NOMESCO Finland
CT of neck arteries
2.9
8.1
37
131
SDA03
NOMESCO Finland
Periodontal treatment
0.6
8.1
136
2093
M54.4
ICD-10 Finland
Lumbago with sciatica
0.4
8.0
35
866
OAB43, ,
SPAT
0.5
7.9
81
1445
EB4VA, ,
NOMESCO Finland
0.4
7.8
30
788
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
0.5
7.7
84
1473
Z71.8
ICD-10 Finland
Other specified counselling
0.5
7.7
95
1602
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
18.6
7.6
11
6
N03AX22
ATC
perampanel; oral
25.3
7.6
10
*
F80.1
ICD-10 Finland
Expressive language disorder
10.2
7.6
14
14
WZC30, ,
SPAT
0.2
7.5
9
388
C10AA05
ATC
atorvastatin; oral
0.6
7.5
158
2306
2151
FHL
Resection, big brain
80.9
7.4
8
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
80.9
7.4
8
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
80.9
7.4
8
*
SPAT1290
SPAT
Preparation of deceased person
80.9
7.4
8
*
XX1AD
NOMESCO Finland
Other CT-examination
80.9
7.4
8
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.4
7.4
28
743
G30.1
ICD-10 Finland
Alzheimer disease with late onset
0.0
7.4
*
213
9400/3-C71.3
ICD-O-3
Astrocytoma, NOS, of parietal lobe
+∞
7.3
7
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
7.3
7
*
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
+∞
7.3
7
*
C72.9
ICD-10 Finland
Malignant neoplasm: Central nervous system, unspecified
+∞
7.3
7
*
C71.89
ICD-10 Finland
Overall malignant tumor of the brain other or unspecified histology
+∞
7.3
7
*
C71.09
ICD-10 Finland
Malignant tumor of the cerebrum except lobes and ventricles other or unspecified histology
+∞
7.3
7
*
A10BA02
ATC
metformin; oral
0.5
7.3
87
1486
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
20.3
7.1
10
5
R03AC02
ATC
salbutamol; inhalant
0.6
7.1
223
2976
WX002
NOMESCO Finland
Sedation and analgesia
1.8
7.0
127
785
C01DA14
ATC
isosorbide mononitrate; oral
0.3
7.0
24
667
U07.2
ICD-10 Finland
COVID-19, virus not identified
0.4
6.8
36
826
I10
ICD-10 Finland
Essential (primary) hypertension
0.7
6.8
275
3492
L03AA13
ATC
pegfilgrastim; parenteral
40.4
6.8
8
*
207
Kela drug reimbursment
Chronic arrhythmias
0.4
6.7
27
699
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
22.8
6.7
9
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.4
6.6
25
663
SFA10
NOMESCO Finland
One-surface restoration
0.7
6.6
229
3005
H25.1
ICD-10 Finland
Senile nuclear cataract
0.5
6.5
69
1226
N05AD01
ATC
haloperidol; systemic
3.1
6.4
26
86
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
4.1
6.4
17
42
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
+∞
6.3
6
*
116
Kela drug reimbursment
Prostate cancer
+∞
6.3
6
*
N75
ICPC
Benign neoplasm nervous system
+∞
6.3
6
*
AA5NK
NOMESCO Finland
Tractography within white matter of central nervous system
+∞
6.3
6
*
N03AF04
ATC
eslicarbazepine; oral
+∞
6.3
6
*
WPA42
NOMESCO Finland
Family-centered psychosocial intervention in palliative care
+∞
6.3
6
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
6.3
6
*
AA003
NOMESCO Finland
Adjuvant radiotherapy of brain
+∞
6.3
6
*
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
6.3
6
*
C71.49
ICD-10 Finland
Malignant tumor in occipital lobe other or unspecified histology
+∞
6.3
6
*
1CD02, ,
NOMESCO Finland
+∞
6.3
6
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
6.3
6
*
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
26.9
6.2
8
*
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.2
6.1
50
235
HA1AA
NOMESCO Finland
X-ray mammography
3.1
6.1
25
83
A10BK03
ATC
empagliflozin; oral
0.3
6.0
15
494
G81.9
ICD-10 Finland
Hemiplegia, unspecified
6.1
6.0
15
25

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
430
159
66.20
307.65
1.3
1.3
—
—
—
0
0
330
675
8.21
171.49
5.4
7.9
0.99
1.15
mmol/l
0.43
263
568
330
685
8.08
168.77
5.5
7.9
4.92
5.15
kpa
4.86
323
664
330
685
8.08
168.77
5.5
7.9
18.16
11.60
kpa
44.82
323
666
330
686
8.07
168.51
5.5
7.9
7.42
7.42
ph
0.60
222
393
237
348
9.69
164.58
5.0
9.1
24.46
24.47
mmol/l
0.02
237
343
359
913
6.88
146.82
1.8
1.9
26.63
29.54
s
10.88
348
887
472
1835
5.61
111.83
3.2
1.7
—
—
—
0
0
434
1705
4.92
97.79
2.1
2.1
—
—
—
0
0
369
1291
4.83
96.37
1.9
2.1
—
—
—
0
0
78
64
13.56
79.99
1.8
1.2
—
—
—
0
0
554
2901
5.02
79.03
14.5
4.1
9.97
12.12
umol/l
7.41
549
2752
418
1879
3.94
71.68
10.3
5.6
—
—
—
0
0
496
2527
4.13
70.05
6.2
5.7
1.19
1.21
mmol/l
8.73
488
2311
428
2000
3.83
68.23
2.6
2.2
181.20
257.48
u/l
0.81
420
1889
345
1416
3.77
66.69
3.7
3.6
95.72
88.29
%
8.30
337
1379
488
2544
3.88
64.58
2.6
2.5
—
—
estimate
—
0
0
90
126
8.03
62.37
1.8
1.1
—
—
—
0
0
67
66
11.10
60.81
1.8
1.1
—
—
—
0
0
511
2842
3.79
59.04
7.1
6.1
1.20
1.21
mmol/l
4.23
466
2465
546
3180
4.02
58.53
18.2
7.0
4.56
4.27
e9/l
2.00
463
2772
477
2677
3.34
51.32
10.4
6.1
8.29
8.86
%
3.94
472
2519
473
2675
3.26
49.54
10.4
6.0
1.47
2.95
%
47.19
466
2512
83
138
6.67
48.91
1.8
1.2
49.66
34.45
e6/l
0.21
61
107
472
2679
3.24
48.86
10.4
6.1
0.41
0.69
%
25.66
466
2512
83
140
6.57
48.22
1.9
1.2
3256.13
1502.28
e6/l
0.35
62
112
477
2738
3.22
48.14
10.6
6.0
21.08
27.91
%
32.84
472
2603
75
2687
0.19
46.43
1.5
1.9
1.39
1.38
mmol/l
0.04
62
2285
458
6092
0.31
45.95
3.4
5.3
4.84
4.59
mmol/l
5.21
417
5706
458
6061
0.32
43.33
3.4
5.2
1.42
1.42
mmol/l
0.03
418
5650
475
6169
0.32
42.99
3.7
6.0
2.96
2.69
mmol/l
6.93
431
5768
487
2959
3.02
41.91
10.4
5.9
0.54
0.58
e9/l
4.41
402
2558
487
2970
3.00
41.42
10.4
5.9
0.03
0.04
e9/l
21.35
400
2575
157
511
3.65
40.65
5.6
7.6
—
—
—
0
0
323
1608
2.84
40.16
1.3
1.4
—
—
—
0
0
493
3071
2.94
39.46
11.0
6.2
0.10
0.20
e9/l
54.12
406
2697
486
3022
2.89
38.70
10.6
6.0
1.37
1.88
e9/l
38.06
406
2666
432
5806
0.35
37.90
4.4
6.6
38.65
39.51
mmol/mol
1.36
398
5463
339
1793
2.69
36.58
10.2
2.1
2.36
2.35
mmol/l
0.70
325
1584
299
1489
2.73
36.34
3.3
4.0
—
—
—
0
0
48
64
7.97
34.33
1.9
1.2
—
—
—
0
0
42
50
8.86
32.91
1.5
1.2
2.21
1.88
mmol/l
1.26
37
45
459
5898
0.38
31.22
4.3
5.2
5.90
5.98
mmol/l
0.63
418
5448
448
5795
0.39
29.93
3.2
4.4
1.33
1.32
mmol/l
0.07
409
5357
431
2737
2.44
29.33
7.9
14.8
1.08
1.27
inr
16.20
378
2278
291
1658
2.27
24.12
3.2
3.2
7.41
7.40
ph
4.14
194
1189
381
2434
2.21
23.66
5.0
4.0
34.58
36.28
g/l
7.39
368
2265
101
355
3.15
22.42
6.0
5.9
—
—
—
0
0
183
889
2.42
21.61
2.1
2.7
0.86
0.82
mmol/l
3.82
177
835
102
377
2.99
20.70
7.7
7.9
24.93
24.68
mmol/l
0.41
97
365
574
4457
2.45
20.58
16.7
5.9
67.47
75.56
u/l
11.54
567
4179
122
505
2.71
20.01
2.0
6.6
6.29
9.60
mmol/l
9.41
114
487
59
161
3.90
19.28
7.7
8.3
1.92
1.33
mmol/l
1.59
54
147
129
572
2.53
18.32
2.1
1.8
291.42
371.80
nmol/l
4.70
119
536
116
2310
0.41
17.99
2.9
3.5
8.82
7.92
mmol/l
0.85
97
1982
104
2167
0.39
17.95
3.1
3.6
72.51
44.05
mg/l
0.58
71
1413
116
2205
0.43
15.35
3.6
4.3
11.02
7.70
mg/mmol
0.43
66
1407
144
2489
0.47
14.49
2.5
3.2
—
—
—
0
0
366
2592
1.84
14.27
17.4
9.8
0.00
0.00
e9/l
1.74
268
2145
461
5547
0.53
14.22
4.1
5.0
1.71
1.92
mu/l
4.13
427
5118
31
1053
0.26
13.62
1.1
1.3
13.33
9.19
u/ml
0.13
14
400
104
476
2.39
13.59
3.4
4.4
1.76
0.68
%
5.65
74
95
171
2742
0.51
13.45
2.3
3.0
161.98
125.55
ug/l
0.93
153
2558
167
2686
0.51
13.17
2.0
2.4
73.36
77.07
nmol/l
1.02
154
2415
247
1582
1.86
13.02
2.5
3.1
—
—
—
0
0
162
904
2.02
12.87
2.2
2.8
2.79
1.80
e6/l
0.68
76
430
183
1073
1.95
12.59
3.6
2.0
2.45
2.43
mmol/l
1.17
169
951
244
1591
1.81
11.94
2.4
2.9
0.41
0.36
e6/l
0.16
172
1156
21
37
5.82
11.53
1.3
1.9
38.12
42.65
%
0.63
21
37
601
6573
0.47
11.50
40.6
20.4
7.26
6.68
e9/l
7.85
586
6417
601
6572
0.47
11.45
40.6
20.4
4.43
4.58
e12/l
12.16
586
6417
366
4601
0.58
11.30
3.6
4.1
14.68
14.80
pmol/l
0.33
339
4220
601
6568
0.47
11.25
40.7
20.4
232.16
245.40
e9/l
4.61
587
6427
45
1146
0.35
11.19
1.1
1.3
11.15
33.92
iu/ml
8.49
11
325
188
2798
0.56
10.69
1.8
2.1
92.73
96.26
pmol/l
0.57
100
1464
33
93
3.67
10.31
2.4
3.7
2.58
2.36
mmol/l
0.18
26
58
17
13
13.36
10.20
1.2
1.9
34.24
25.46
%
1.29
17
13
165
999
1.85
10.04
2.3
2.7
1.39
0.95
e6/l
0.44
81
528
247
1694
1.70
9.73
12.3
4.8
—
—
—
0
0
110
1882
0.51
9.71
2.1
3.1
455.96
1192.66
ng/l
10.95
94
1588
16
12
13.61
9.70
1.2
2.0
5.81
5.92
%
0.02
16
12
51
197
2.71
9.45
7.9
2.9
174.95
257.91
mg/l
1.13
44
75
104
1772
0.52
8.91
1.4
1.7
17.36
20.07
nmol/l
1.81
93
1505
90
462
2.08
8.80
3.3
4.2
1.38
0.45
%
1.67
61
99
185
1213
1.71
8.41
2.9
4.0
51.97
637.43
ng/l
4.87
137
937
259
1861
1.61
8.21
2.6
3.1
29.82
92.15
e6/l
0.96
184
1415
174
2478
0.61
7.48
3.5
4.0
2.14
1.79
ug/l
0.57
151
2245
18
28
6.57
7.45
1.2
1.2
—
—
—
0
0
98
1601
0.55
7.01
2.0
2.3
333.04
353.89
umol/l
1.29
84
1404
85
465
1.94
6.95
3.6
4.5
0.16
0.08
%
0.76
55
84
89
1468
0.55
6.52
3.1
3.8
1.02
1.02
kg/l
0.21
67
961
83
1392
0.54
6.43
1.2
1.3
1.14
1.71
u/ml
0.33
17
405
18
35
5.25
6.35
3.3
3.9
—
—
—
0
0
10
422
0.23
6.14
1.0
1.3
75.00
304.12
u/ml
—
10
397
177
2396
0.65
5.62
3.3
3.6
0.00
0.01
estimate
0.80
45
478
87
514
1.79
5.59
3.1
3.5
7.39
7.35
ph
1.78
75
353
7
286
0.24
5.40
1.3
1.8
—
—
—
0
0
10
11
9.20
5.30
3.4
8.4
8.70
10.27
%
—
10
11
10
11
9.20
5.30
1.7
4.2
33.00
43.45
%
—
10
11
272
2129
1.45
5.23
3.0
3.7
40.58
91.62
e6/l
1.89
188
1486
44
848
0.49
5.22
1.0
1.2
—
—
—
0
0
35
732
0.45
5.22
1.6
1.6
—
—
—
0
0
28
110
2.61
5.10
1.9
3.6
—
—
—
0
0
96
1452
0.61
4.89
2.4
2.8
0.56
0.71
ug/l
2.33
62
863
15
35
4.35
4.65
1.5
1.3
0.48
0.49
ratio
—
7
23
122
1726
0.65
4.59
3.2
3.8
0.00
0.01
estimate
0.50
45
547
150
1071
1.51
4.52
2.3
2.6
545.37
529.54
mosm/kgh2o
0.40
133
934
8
269
0.29
4.18
1.1
2.0
—
6.86
—
0
63
7
243
0.28
3.93
1.3
1.2
0.77
0.91
g/l
—
7
243
8
11
7.34
3.86
1.0
1.0
—
—
—
0
0
7
8
8.82
3.78
1.0
2.1
—
—
—
0
0
142
1886
0.69
3.76
2.3
2.4
52.33
59.69
u/l
1.66
133
1744
293
2429
1.35
3.69
3.4
3.8
16.63
94.93
ng/l
1.88
242
1740
7
235
0.29
3.64
1.3
1.2
1.45
1.49
g/l
—
7
235
32
603
0.51
3.55
1.3
1.4
—
—
—
0
0
45
765
0.56
3.55
2.2
2.7
171.17
138.53
ug/g
0.31
36
616
87
1256
0.65
3.51
1.4
1.7
455.34
43035980.51
pmol/l
1.65
71
1041
53
858
0.59
3.49
1.1
1.4
288.00
489.84
titre
—
5
187
109
1499
0.68
3.44
1.7
2.2
2.78
2.77
mg/l
0.01
88
1282
38
203
1.92
3.41
1.4
1.6
0.14
1.58
ug/l
2.90
32
181
36
641
0.54
3.34
1.2
1.4
—
—
—
0
0
269
3175
0.76
3.24
3.0
3.7
0.00
2.97
estimate
0.50
55
589
92
636
1.51
3.21
1.9
2.2
5.71
7.07
umol/l
0.58
79
555
209
2553
0.74
3.20
2.8
3.3
6.28
6.23
ph
0.26
113
1445
38
657
0.55
3.19
1.7
2.5
15.46
15.09
nmol/l
0.10
33
611
83
1186
0.66
3.17
1.2
1.3
2.20
2.59
g/l
0.84
44
738
34
602
0.54
3.10
1.5
1.4
—
—
—
0
0
73
485
1.56
3.06
3.8
4.6
0.07
0.00
%
0.74
43
80
266
3127
0.76
3.05
3.1
3.6
0.00
0.00
estimate
-0.00
51
583
38
642
0.57
2.94
1.1
1.4
—
—
—
0
0
13
318
0.40
2.92
1.2
1.7
0.31
0.35
mg/l
—
6
157
9
23
3.95
2.78
1.1
1.1
—
—
—
0
0
12
40
3.03
2.70
2.3
1.3
—
—
—
0
0
276
3193
0.78
2.67
3.1
3.7
0.00
0.01
estimate
0.93
51
548
46
283
1.67
2.65
2.1
1.6
3.24
2.67
ug/l
0.39
28
211
7
15
4.70
2.60
1.0
1.1
—
—
—
0
0
441
3987
1.28
2.57
4.0
4.3
—
4.01
—
0
6
6
182
0.32
2.55
1.2
1.2
—
2.53
—
0
19
5
8
6.28
2.37
1.4
1.0
—
—
—
0
0
5
8
6.28
2.37
1.4
1.0
—
—
—
0
0
5
8
6.28
2.37
1.4
1.0
—
—
—
0
0
14
300
0.46
2.31
1.4
2.1
43.36
38.61
nmol/l
0.48
14
290
162
1308
1.31
2.30
6.5
4.5
—
—
—
0
0
35
562
0.60
2.26
2.3
2.0
0.00
0.00
estimate
—
5
104
68
942
0.69
2.20
1.5
2.4
15.25
13.46
umol/l
1.25
63
877
83
612
1.40
2.12
2.1
3.0
2.17
1.97
mmol/l
0.26
77
523
0
55
0.00
2.07
0.0
1.2
—
1.10
—
0
31
136
1674
0.77
2.05
3.1
3.1
0.00
0.00
estimate
-0.00
40
458
58
405
1.47
1.99
1.3
1.4
—
54.69
—
0
34
64
873
0.71
1.91
1.5
2.4
2.30
2.31
g/l
0.07
58
815
12
53
2.29
1.81
1.3
1.4
0.70
1.33
promille
0.80
12
44
21
360
0.57
1.79
1.1
1.1
—
—
—
0
0
83
633
1.35
1.75
2.0
3.1
7.40
7.38
ph
1.60
45
367
8
30
2.68
1.72
3.3
3.2
0.63
1.03
index
—
8
30
59
799
0.71
1.70
1.6
2.5
26.89
23.43
%
0.83
53
749
21
119
1.79
1.68
2.1
2.3
15.07
53.71
u/ml
0.46
15
95
17
302
0.55
1.65
1.4
1.2
—
—
—
0
0
8
172
0.46
1.60
1.5
1.7
—
—
—
0
0
12
233
0.51
1.56
1.1
1.1
—
—
—
0
0
34
500
0.66
1.54
3.6
2.3
0.70
0.26
e6/l
0.39
34
472
229
2017
1.20
1.46
5.7
2.8
27.95
33.96
u/l
3.28
222
1898
5
123
0.40
1.38
2.2
3.6
0.70
0.80
nmol/l
—
5
106
5
17
2.95
1.36
1.8
1.2
2.58
1.85
umol/l
—
5
12
9
43
2.11
1.30
1.0
1.2
—
—
—
0
0
17
280
0.60
1.30
1.2
1.7
—
—
—
0
0
28
411
0.67
1.29
1.2
1.3
—
—
—
0
0
14
237
0.58
1.20
1.1
1.2
—
0.86
—
0
14
13
72
1.82
1.15
1.1
1.2
—
—
—
0
0
0
35
0.00
1.15
0.0
1.1
—
196.97
—
0
35
7
30
2.35
1.12
1.0
1.6
—
—
—
0
0
15
242
0.61
1.08
1.7
1.3
—
—
—
0
0
16
97
1.66
1.07
1.8
1.8
—
—
—
0
0
5
22
2.28
1.03
1.0
1.3
—
—
—
0
0
17
106
1.62
1.03
1.1
1.3
—
—
—
0
0
28
391
0.70
1.03
1.1
1.2
98.36
128.43
u/ml
—
7
167
11
189
0.58
1.02
3.9
1.8
—
—
—
0
0
150
1703
0.85
1.01
2.7
2.8
0.00
0.07
—
5
30
13
213
0.60
1.01
5.6
10.0
—
—
—
0
0
27
191
1.43
0.96
1.1
1.2
—
—
—
0
0
0
32
0.00
0.95
0.0
1.1
—
—
—
0
0
6
116
0.51
0.94
1.2
2.1
4.22
5.16
mmol/24h
—
6
105
6
28
2.15
0.91
2.7
2.8
—
—
—
0
0
17
110
1.56
0.91
2.5
2.7
63.53
57.88
%
0.87
17
110
11
182
0.60
0.90
1.4
1.1
—
—
—
0
0
20
135
1.50
0.90
1.1
1.2
—
—
—
0
0
20
135
1.50
0.90
3.8
4.1
—
—
—
0
0
8
42
1.91
0.88
3.5
1.9
16.38
20.64
nmol/l
—
8
35
38
290
1.33
0.88
2.7
2.9
25.33
25.13
mmol/l
0.17
38
279
6
30
2.01
0.87
2.3
2.8
—
—
—
0
0
81
681
1.21
0.86
1.5
1.7
—
—
—
0
0
15
227
0.65
0.85
1.1
1.2
—
—
—
0
0
14
88
1.60
0.85
2.5
3.0
5.79
4.14
e9/l
0.75
14
88
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
0
24
0.00
0.79
0.0
1.1
—
—
—
0
0
11
66
1.68
0.79
1.0
1.8
12.77
10.53
%
0.59
11
66
9
53
1.71
0.75
1.3
1.2
—
—
—
0
0
9
55
1.64
0.73
2.7
2.5
—
28.48
—
0
6
5
26
1.93
0.70
2.6
3.0
—
—
—
0
0
11
69
1.60
0.68
1.1
1.5
—
—
—
0
0
11
69
1.60
0.68
1.1
1.5
—
—
—
0
0
11
69
1.60
0.68
1.1
1.5
—
—
—
0
0
11
69
1.60
0.68
1.1
1.5
—
—
—
0
0
5
27
1.86
0.68
1.0
4.2
343.80
612.11
u/ml
—
5
27
39
483
0.80
0.68
1.1
1.2
—
—
—
0
0
49
404
1.23
0.66
2.3
2.7
137.63
132.95
g/l
1.20
49
394
5
28
1.79
0.66
1.0
1.1
—
—
—
0
0
11
70
1.58
0.65
3.8
2.2
1.18
1.18
mmol/l
0.00
11
70
86
979
0.86
0.63
1.6
1.7
918.28
1164.07
nmol/l
2.30
61
749
17
121
1.41
0.62
1.1
1.2
169.45
245.48
u/ml
0.75
12
63
12
176
0.68
0.62
1.2
1.3
—
7.58
—
0
5
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
2.2
—
8.32
—
0
17
11
72
1.54
0.59
3.8
2.1
103.36
105.79
mmol/l
1.35
11
72
11
72
1.54
0.59
3.8
2.1
4.15
4.07
mmol/l
0.28
11
72
8
53
1.52
0.58
1.4
1.4
19.65
25.89
ng/l
—
8
53
0
23
0.00
0.58
0.0
3.3
—
38.64
—
0
7
11
161
0.68
0.57
2.4
2.2
154.00
138.65
ug/min
—
6
94
41
338
1.23
0.57
2.0
2.3
0.62
0.60
%
0.17
41
338
90
798
1.15
0.56
1.3
1.6
—
—
—
0
0
22
169
1.31
0.53
1.1
1.1
—
—
—
0
0
41
343
1.21
0.51
2.0
2.4
1.16
1.27
%
0.39
41
343
419
4334
0.92
0.50
3.3
4.1
—
68672.17
—
0
6
43
507
0.84
0.50
1.2
1.9
—
—
—
0
0
19
146
1.31
0.47
4.1
3.1
2.64
1.52
index
0.45
14
75
140
1291
1.10
0.47
2.3
2.4
6.39
5.51
e6/l
0.25
130
1169
5
81
0.61
0.46
1.0
1.3
—
—
—
0
0
6
91
0.66
0.42
1.2
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
8.7
—
5.29
—
0
15
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
0.78
—
0
8
0
16
0.00
0.41
0.0
2.9
—
—
—
0
0
0
16
0.00
0.41
0.0
2.1
—
—
—
0
0
0
16
0.00
0.41
0.0
2.2
—
0.19
—
0
16
0
17
0.00
0.40
0.0
1.0
—
7.97
—
0
11
0
18
0.00
0.40
0.0
1.2
—
109.52
—
0
13
0
18
0.00
0.40
0.0
1.1
—
37.83
—
0
12
5
35
1.43
0.39
1.2
1.1
—
—
—
0
0
5
36
1.39
0.38
1.2
1.1
—
—
—
0
0
91
832
1.11
0.37
1.5
2.1
—
—
—
0
0
70
774
0.89
0.37
1.3
1.5
—
—
—
0
0
6
43
1.40
0.35
1.3
1.2
—
—
—
0
0
6
46
1.31
0.33
1.0
1.1
141.33
109.65
pmol/l
—
6
46
53
477
1.12
0.30
1.2
1.1
—
—
—
0
0
32
366
0.87
0.29
1.2
1.3
—
—
—
0
0
8
63
1.27
0.28
2.1
2.3
—
—
—
0
0
14
171
0.82
0.26
1.3
1.3
32.64
41.28
mg/l
—
8
147
14
171
0.82
0.26
1.3
1.3
21.53
32.40
mg/l
—
9
147
46
415
1.12
0.26
3.0
3.5
—
—
—
0
0
46
416
1.11
0.25
1.2
1.5
—
—
—
0
0
45
495
0.90
0.24
1.9
2.1
69.17
67.96
e9/l
0.07
27
368
0
11
0.00
0.21
0.0
1.0
—
5.14
—
0
11
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
6.3
—
7.51
—
0
10
8
103
0.77
0.21
1.1
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
2.6
—
—
—
0
0
0
14
0.00
0.20
0.0
3.0
—
117762.22
—
0
9
6
52
1.16
0.19
2.7
1.6
1357.00
1108.98
mg
—
6
52
22
194
1.14
0.18
1.3
1.6
—
—
—
0
0
13
109
1.20
0.18
1.5
2.0
—
—
—
0
0
14
163
0.86
0.17
1.3
2.3
25.35
11.27
mg/l
0.46
14
153
126
1311
0.95
0.17
1.5
1.6
2.78
1.05
mg/l
1.94
106
995
8
97
0.82
0.13
1.0
1.0
—
—
—
0
0
26
282
0.92
0.12
2.2
2.3
—
—
—
0
0
30
278
1.08
0.12
1.8
3.5
—
—
—
0
0
62
646
0.96
0.10
1.8
2.1
2.00
1.74
%
0.75
52
578
421
4171
1.02
0.09
3.9
3.3
63.79
47.13
u/l
1.21
407
3942
595
5921
1.03
0.08
27.2
13.2
18.31
23.72
mg/l
7.64
572
4731
6
58
1.03
0.08
2.3
2.2
—
—
—
0
0
5
61
0.82
0.08
1.0
1.3
—
—
—
0
0
8
76
1.05
0.07
1.4
1.1
—
—
—
0
0
8
78
1.03
0.07
1.4
1.4
—
—
nmol/l
—
0
0
8
92
0.87
0.06
1.0
1.1
1.42
1.51
g/l
—
8
84
8
93
0.86
0.06
1.1
1.6
—
—
—
0
0
8
95
0.84
0.06
1.1
1.7
—
—
—
0
0
8
95
0.84
0.06
1.1
1.1
—
19.87
—
0
32
100
1022
0.97
0.06
1.4
1.9
—
—
—
0
0
48
463
1.04
0.06
2.8
2.5
6.34
6.05
ph
1.61
41
306
9
102
0.88
0.06
1.1
3.2
5.00
9.31
pmol/l
—
9
102
56
543
1.03
0.06
2.1
2.2
31.46
41.46
u/l
0.58
50
439
67
653
1.03
0.05
1.2
1.6
—
—
—
0
0
47
458
1.03
0.03
2.0
3.5
68.05
190.37
ng/l
5.64
40
424
16
169
0.95
0.03
1.3
2.1
—
—
—
0
0
24
249
0.96
0.02
1.3
1.7
—
—
—
0
0
43
440
0.98
0.02
1.7
1.5
65.24
67.59
g/l
1.11
38
407
14
148
0.94
0.02
1.3
1.2
1.66
1.34
ratio
—
6
90
24
248
0.97
0.02
1.3
1.7
—
—
—
0
0
11
113
0.97
0.00
1.4
1.1
—
—
—
0
0
24
236
1.02
0.00
1.3
1.7
—
—
—
0
0
11
112
0.98
0.00
1.4
1.1
—
—
—
0
0
25
251
1.00
0.00
1.3
1.7
—
—
—
0
0
60
599
1.00
0.00
1.5
2.4
3.57
8.07
ug/l
5.09
52
538
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
6
67
0.89
0.00
1.8
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
22.4
—
0.14
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
87
0.92
-0.00
1.3
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
0.03
—
0
9
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.7
—
10.71
—
0
7
25
250
1.00
-0.00
1.3
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
82
0.98
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
2.29
—
0
9
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
320.00
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
0.05
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
363.80
—
0
6
0
7
0.00
-0.00
0.0
2.0
—
0.54
—
0
7
6
63
0.95
-0.00
1.2
1.7
38.17
32.70
u/ml
—
6
58
0
7
0.00
-0.00
0.0
1.1
—
52.26
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
183.40
—
0
5

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_GBM_ASTROCYTOMA – Brain glioblastoma and astrocytoma

GWS hits: 4

This endpoint is excluded from FinRegistry analyses (omitted endpoint).