No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
115 |
4. Check minimum number of eventsNone |
115 |
5. Include endpointsNone |
115 |
6. Filter based on genotype QC (FinnGen only) |
102 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_RESPI_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q3[0-4]
- Name in latin
- Malformationes congenitae laryngis
Similar endpoints
↥List of similar endpoints to
Congenital malformations of larynx
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the respiratory system
- Congenital malformations of the respiratory system, including avohilmo
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities, including avohilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2624 | 1091 | 1532 |
| Only index persons | 1351 | 574 | 777 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.03 | 0.04 |
| Only index persons | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 0.34 | 0.30 | 0.37 |
| Only index persons | 0.49 | 0.48 | 0.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 102 | 53 | 49 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 5.00 | 8.87 | 0.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 110
- Matched controls
- 1099
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q31.40
ICD-10 Finland
Congenital laryngomalasia
984.4
59.6
53
*
Q31.3
ICD-10 Finland
Laryngocele
+∞
29.5
27
*
Q31.1
ICD-10 Finland
Congenital subglottic stenosis
+∞
16.0
15
*
UGC02
NOMESCO Finland
Rigid bronchoscopy
53.2
15.6
18
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
12.7
14.5
26
26
DQB10
NOMESCO Finland
Endoscopic excision of lesion of larynx
+∞
12.7
12
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.8
10.9
65
302
WX408
NOMESCO Finland
General anesthesy, balanced
3.4
8.9
51
224
WX402
NOMESCO Finland
General anaesthesia
3.1
7.6
47
213
R06.1
ICD-10 Finland
Stridor
85.5
7.5
8
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
85.5
7.5
8
*
UGB02
NOMESCO Finland
Tracheoscopy
85.5
7.5
8
*
UDQ22
NOMESCO Finland
Microlaryngoscopy
+∞
7.4
7
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.9
7.2
24
73
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.8
7.0
17
40
UDQ02
NOMESCO Finland
Direct laryngoscopy
18.1
6.9
10
6
UDQ12
NOMESCO Finland
Flexible laryngoscopy
8.3
6.6
14
19
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
9.0
6.5
13
16
Z01.8
ICD-10 Finland
Other specified special examinations
3.1
6.4
35
145
Q31.48
ICD-10 Finland
Other congenital laryngeal warts
+∞
6.3
6
*
DQD40
NOMESCO Finland
Plastic repair of larynx
+∞
6.3
6
*
J38.6
ICD-10 Finland
Stenosis of larynx
+∞
6.3
6
*
DQW99
NOMESCO Finland
Other operation on larynx
+∞
6.3
6
*
Q32.0
ICD-10 Finland
Congenital tracheomalacia
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
14
48
3.19
3.44
2.1
1.9
—
—
—
0
0
14
52
2.94
3.01
2.3
2.0
—
—
—
0
0
82
638
2.12
2.95
11.2
13.9
3.88
3.66
e9/l
0.44
65
515
38
227
2.03
2.92
11.4
11.7
1.52
1.01
mmol/l
0.86
28
172
25
127
2.25
2.89
2.8
2.0
—
—
—
0
0
29
160
2.10
2.73
2.6
2.1
—
—
—
0
0
10
31
3.44
2.59
1.4
1.6
—
—
—
0
0
24
127
2.14
2.50
2.8
2.1
—
—
—
0
0
6
12
5.21
2.43
1.3
1.1
—
—
—
0
0
6
12
5.21
2.43
1.7
1.5
—
—
—
0
0
8
24
3.51
2.22
1.3
1.5
—
—
—
0
0
10
37
2.87
2.13
1.6
1.5
—
—
—
0
0
10
37
2.87
2.13
1.6
1.5
—
—
—
0
0
33
208
1.84
2.09
2.9
3.6
71.22
19.98
ng/l
0.43
21
114
5
10
5.17
2.09
1.4
1.0
—
—
—
0
0
15
71
2.29
2.03
9.5
21.7
0.55
0.63
%
0.48
15
71
15
72
2.25
1.97
9.5
21.4
1.15
1.32
%
0.25
15
72
7
23
3.17
1.83
2.1
1.7
—
—
—
0
0
8
31
2.70
1.69
1.4
1.7
—
—
—
0
0
65
517
1.63
1.68
26.0
14.1
1.23
1.23
mmol/l
0.15
58
475
6
19
3.27
1.68
1.8
3.6
18.02
17.28
%
—
6
19
6
19
3.27
1.68
1.5
1.8
—
—
—
0
0
48
356
1.62
1.64
10.0
9.3
37.94
36.24
g/l
1.69
48
341
10
43
2.45
1.64
1.9
1.6
—
—
—
0
0
50
375
1.61
1.63
4.1
3.5
—
—
estimate
—
0
0
5
14
3.68
1.63
2.2
1.7
29915.60
14994.29
e6/l
—
5
7
8
32
2.61
1.63
1.3
1.6
35.75
45.43
u/l
—
8
27
14
71
2.11
1.62
2.0
1.6
—
—
—
0
0
26
165
1.75
1.59
4.2
6.2
569.35
1038.23
ng/l
1.34
26
145
5
15
3.44
1.54
2.4
2.0
—
—
—
0
0
11
52
2.24
1.50
7.6
9.3
66.61
56.85
%
0.57
11
52
31
211
1.65
1.47
7.4
13.0
24.55
23.35
mmol/l
1.58
31
211
10
46
2.29
1.44
2.2
1.3
—
—
—
0
0
12
60
2.12
1.44
12.0
2.7
—
—
—
0
0
24
156
1.69
1.34
5.1
3.5
14.69
14.53
umol/l
0.04
24
148
21
133
1.71
1.29
5.3
4.3
511.93
846.86
ng/l
0.42
14
95
31
220
1.57
1.23
3.9
3.4
—
—
—
0
0
6
26
2.38
1.20
1.3
1.5
—
—
—
0
0
0
33
0.00
1.18
0.0
1.3
—
87.00
—
0
6
100
922
1.92
1.15
29.4
18.4
139.94
139.51
mmol/l
1.28
100
903
100
923
1.91
1.12
30.2
18.3
4.01
3.98
mmol/l
0.32
100
896
5
22
2.33
1.04
3.0
7.7
66.00
94.41
%
—
5
22
30
222
1.48
0.98
19.5
11.4
1.28
1.36
mmol/l
0.49
30
209
0
32
0.00
0.96
0.0
2.1
—
0.45
—
0
27
37
288
1.43
0.93
4.5
5.7
29.30
32.59
u/l
0.67
37
281
42
336
1.40
0.90
4.2
4.7
0.24
0.30
e6/l
0.16
31
229
11
64
1.80
0.89
2.9
1.7
—
—
—
0
0
6
30
2.05
0.88
1.2
1.4
—
—
—
0
0
101
950
1.76
0.86
21.5
15.7
69.75
61.58
umol/l
0.38
101
932
33
255
1.42
0.86
1.7
1.8
106.10
91.42
pmol/l
1.78
17
131
30
229
1.42
0.83
5.5
4.2
0.00
0.00
estimate
-0.00
12
71
20
141
1.51
0.81
1.5
1.2
18.00
15.17
iu/ml
—
5
34
0
24
0.00
0.80
0.0
2.3
—
2.41
—
0
18
17
116
1.55
0.80
2.5
4.6
0.18
0.20
g/l
0.69
17
111
32
250
1.39
0.78
22.3
19.2
24.91
24.73
mmol/l
0.15
32
250
18
126
1.51
0.76
1.4
1.2
54.90
5.42
u/ml
—
6
45
13
84
1.62
0.75
1.8
2.8
24.14
15.13
iu/l
—
8
62
19
135
1.49
0.75
15.6
16.4
105.32
104.56
mmol/l
0.27
19
135
57
491
1.33
0.74
5.2
4.6
0.00
0.00
estimate
-0.00
13
71
7
39
1.85
0.74
1.1
3.0
—
—
—
0
0
5
25
2.04
0.73
1.6
1.7
—
—
—
0
0
56
485
1.31
0.68
5.2
4.5
0.00
0.00
estimate
-0.00
14
72
0
20
0.00
0.61
0.0
1.6
—
23.28
—
0
14
8
53
1.55
0.60
9.5
5.9
—
—
—
0
0
29
233
1.33
0.59
4.1
3.5
56.21
54.23
u/l
0.17
29
215
0
23
0.00
0.59
0.0
1.7
—
54.96
—
0
16
6
36
1.70
0.57
1.2
1.5
—
—
—
0
0
9
62
1.49
0.54
45.1
16.0
24.78
24.44
mmol/l
—
9
62
55
488
1.25
0.51
5.3
4.5
0.00
0.00
estimate
-0.00
14
74
7
49
1.46
0.47
1.3
1.5
—
—
—
0
0
12
86
1.44
0.46
1.2
1.4
117.14
158.55
u/ml
—
5
26
13
95
1.42
0.46
3.1
5.0
24.00
22.76
%
—
5
48
18
141
1.33
0.43
6.4
3.5
2.60
2.54
g/l
0.14
18
133
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
15
191
0.75
0.41
2.9
2.7
—
—
—
0
0
66
607
1.22
0.41
18.2
11.7
94.36
92.70
ml/min/173m2
0.18
53
522
0
17
0.00
0.41
0.0
1.2
—
1.56
—
0
9
5
34
1.49
0.41
1.8
1.5
—
—
—
0
0
20
161
1.29
0.40
11.8
12.0
0.85
0.79
mmol/l
1.69
20
156
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
5
35
1.45
0.40
6.6
14.0
—
89.80
—
0
5
9
66
1.39
0.39
2.8
2.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.7
—
0.96
—
0
11
0
19
0.00
0.39
0.0
1.7
—
1.02
—
0
11
0
19
0.00
0.39
0.0
1.7
—
0.90
—
0
11
9
68
1.35
0.39
1.6
1.6
—
—
—
0
0
26
220
1.24
0.36
5.5
3.8
1.02
1.02
kg/l
0.00
18
143
38
336
1.20
0.34
5.0
3.8
0.00
0.02
estimate
0.49
12
61
15
120
1.29
0.32
1.5
1.6
1.29
1.38
%
0.42
15
115
15
183
0.79
0.30
2.5
2.6
—
—
—
0
0
94
906
1.25
0.30
27.9
20.6
13.47
13.35
%
0.49
94
900
5
38
1.33
0.23
3.4
5.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
0.91
—
0
10
0
10
0.00
0.21
0.0
3.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
84.73
—
0
11
0
12
0.00
0.21
0.0
1.3
—
90.75
—
0
12
0
14
0.00
0.20
0.0
1.3
—
69.26
—
0
14
0
14
0.00
0.20
0.0
3.5
—
3.39
—
0
6
11
90
1.25
0.20
40.1
13.0
0.47
0.74
mmol/l
0.15
11
75
36
390
0.88
0.20
1.4
1.8
1.60
2.03
u/ml
—
7
75
26
234
1.14
0.18
3.4
4.7
1.11
0.54
e6/l
0.33
11
132
8
72
1.12
0.16
4.3
8.6
179.88
173.53
%
—
8
72
83
806
1.12
0.15
4.1
3.8
—
—
—
0
0
24
221
1.11
0.12
4.0
4.9
2.90
1.43
e6/l
—
10
122
40
379
1.09
0.11
1.9
2.0
—
—
—
0
0
5
45
1.12
0.10
1.0
1.0
173.00
165.84
g/l
—
5
45
6
55
1.10
0.09
2.5
2.0
—
—
—
0
0
8
76
1.06
0.07
1.1
1.3
—
—
—
0
0
65
665
0.94
0.07
6.0
4.9
35.46
36.89
mmol/mol
1.44
60
631
9
86
1.05
0.07
6.0
9.4
77.89
92.29
%
—
9
86
8
90
0.88
0.07
3.3
2.2
—
—
—
0
0
20
189
1.07
0.05
3.4
4.7
2.62
1.48
mg/l
0.37
14
155
11
102
1.09
0.03
2.3
1.4
—
—
—
0
0
12
112
1.08
0.03
1.0
1.1
—
—
—
0
0
25
242
1.04
0.02
4.0
3.2
0.00
0.00
estimate
-0.00
12
60
54
547
0.97
0.01
4.3
4.9
42.35
35.75
u/l
0.55
54
528
11
105
1.05
0.00
3.1
2.4
—
—
—
0
0
96
957
1.02
0.00
24.5
14.7
26.72
23.41
mg/l
0.38
89
710
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
13.63
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
7
70
1.00
0.00
1.0
1.0
2.84
3.25
kpa
—
7
63
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
0.00
2.5
2.4
—
13198.41
u/l
—
0
20
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.2
—
50.20
—
0
5
0
6
0.00
-0.00
0.0
5.2
—
268.67
—
0
6
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
4.61
—
0
6
7
72
0.97
-0.00
1.0
1.0
8.27
7.50
kpa
—
7
65
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
10.43
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
344.92
—
0
5
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
1.01
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.6
—
300.80
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
2.38
—
0
7
0
9
0.00
-0.00
0.0
4.1
—
0.44
—
0
9
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_LARYNX and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_LARYNX.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_LARYNX – Congenital malformations of larynx
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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