No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
148 |
4. Check minimum number of eventsNone |
148 |
5. Include endpointsNone |
148 |
6. Filter based on genotype QC (FinnGen only) |
148 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_NERVOUS_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- Special
- Q17_HCCONG
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q00-Q07
- Name in latin
- Hydrocephalia congenita
Similar endpoints
↥List of similar endpoints to
Congenital hydrocephalus
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the nervous system
- Hydrocephalus
- Congenital malformations, deformations and chromosomal abnormalities
- Other neurological diseases
- Neurological diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2458 | 1124 | 1328 |
| Only index persons | 1790 | 813 | 977 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.04 |
| Only index persons | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 3.23 | 3.70 | 2.57 |
| Only index persons | 3.93 | 5.20 | 2.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 148 | 74 | 74 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 10.18 | 12.76 | 7.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 135
- Matched controls
- 1347
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
45.4
41
*
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
39.5
36
*
Q03.9
ICD-10 Finland
Congenital hydrocephalus, unspecified
+∞
38.4
35
*
7423A
ICD-9 Finland
Other congenital anomalies of nervous system, Congenital hydrocephalus
+∞
32.6
30
*
74200
ICD-8 Finland
Congenital hydrocephalus, Communicans
+∞
31.5
29
*
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
191.0
30.0
30
*
Q03.0
ICD-10 Finland
Malformations of aqueduct of Sylvius
+∞
29.2
27
*
74209
ICD-8 Finland
Congenital hydrocephalus, Unspecified
+∞
25.9
24
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
25.9
24
*
2133
FHL
Suntin revisio
+∞
23.6
22
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
14.3
19.6
34
31
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
205.9
18.0
18
*
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
17.0
16
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
+∞
17.0
16
*
2132
FHL
Ventricular operators sunt
+∞
15.9
15
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
64.3
15.2
17
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
18.2
15.1
23
15
3313A
ICD-9 Finland
Other cerebral degenerations, Communicating hydrocephalus
+∞
13.8
13
*
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
12.7
12
*
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
+∞
12.7
12
*
H47.2
ICD-10 Finland
Optic atrophy
142.7
12.7
13
*
AA1AA
NOMESCO Finland
Head X-ray examination
130.7
11.6
12
*
Q03.1
ICD-10 Finland
Atresia of foramina of Magendie and Luschka
+∞
10.5
10
*
G91.8
ICD-10 Finland
Other hydrocephalus
+∞
10.5
10
*
74201
ICD-8 Finland
Congenital hydrocephalus, Non communicans
+∞
10.5
10
*
74210
ICD-8 Finland
NA
+∞
10.5
10
*
AA1AD
NOMESCO Finland
CT of head and brain
4.4
10.2
40
117
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
18.5
10.1
15
9
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
59.4
9.8
11
*
AAF00
NOMESCO Finland
Ventriculostomy
107.2
9.5
10
*
3314A
ICD-9 Finland
Other cerebral degenerations, Obstructive hydrocephalus
+∞
9.5
9
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.3
9.0
24
45
183
Kela drug reimbursment
Lamotrigin and topiramate
23.7
8.2
11
5
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.4
8.0
24
52
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
8.9
7.9
16
20
N03AF02
ATC
oxcarbazepine; oral
9.2
7.5
15
18
AAF15
NOMESCO Finland
Ventriculoatrial shunt
+∞
7.4
7
*
Q03.88
ICD-10 Finland
Other congenital hydrocephalus
+∞
7.4
7
*
7410D
ICD-9 Finland
Spina bifida, With hydrocephalus[SPINA BIFIDA APERTA CUM HYDROCEPHALO REG LUMBALIS]
+∞
7.4
7
*
XCK00
NOMESCO Finland
Perimetry
7.7
7.2
16
23
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
42.2
6.8
8
*
R51.80
ICD-10 Finland
Headache
3.5
6.6
32
110
H53.4
ICD-10 Finland
Visual field defects
19.1
6.4
9
5
Q05.2
ICD-10 Finland
Lumbar spina bifida with hydrocephalus
+∞
6.3
6
*
2139
FHL
Other measure in this category
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
7
7
10.41
4.05
3.7
2.6
66.86
52.86
umol/l
—
7
7
7
7
10.41
4.05
1.3
1.3
1.75
1.55
mmol/l
—
7
7
59
386
1.88
3.32
6.7
7.5
1.20
1.21
mmol/l
1.07
53
354
62
418
1.83
3.14
6.2
8.4
1.21
1.21
mmol/l
0.48
51
359
20
91
2.38
2.89
6.6
6.7
—
—
—
0
0
0
62
0.00
2.28
0.0
1.5
—
—
—
0
0
86
1025
0.62
2.14
3.4
3.5
—
—
—
0
0
0
57
0.00
2.10
0.0
1.4
—
—
—
0
0
0
58
0.00
2.09
0.0
1.3
—
—
—
0
0
0
58
0.00
2.09
0.0
1.3
—
—
—
0
0
0
48
0.00
1.73
0.0
1.6
—
—
—
0
0
61
475
1.48
1.51
3.7
4.3
—
—
—
0
0
17
95
1.89
1.50
8.2
12.0
0.81
1.33
mmol/l
—
8
73
10
45
2.31
1.50
14.9
8.8
24.92
24.14
mmol/l
—
10
45
17
281
0.55
1.49
2.9
2.2
—
—
—
0
0
40
286
1.55
1.47
3.4
2.1
338.09
249.37
u/l
0.21
35
275
15
253
0.55
1.41
2.7
2.1
—
—
—
0
0
32
220
1.58
1.39
2.2
2.5
—
—
—
0
0
8
157
0.48
1.34
1.5
1.7
—
—
—
0
0
43
320
1.48
1.31
2.6
3.4
2.37
2.35
mmol/l
0.39
38
281
31
217
1.54
1.25
1.7
1.8
2.99
3.08
mg/l
0.04
25
185
51
397
1.43
1.23
2.6
2.4
69.46
71.95
nmol/l
0.26
45
363
42
318
1.45
1.16
1.7
1.7
97.48
97.61
pmol/l
0.01
21
163
5
20
2.55
1.16
1.4
1.6
—
—
—
0
0
23
331
0.64
1.16
1.8
1.6
—
—
—
0
0
75
630
1.39
1.15
9.5
10.4
4.37
4.03
e9/l
0.57
67
559
43
339
1.38
0.94
2.9
2.9
—
—
—
0
0
22
305
0.67
0.92
1.2
1.3
0.90
1.36
u/ml
—
5
74
13
79
1.71
0.91
3.3
3.5
—
—
—
0
0
15
96
1.63
0.88
3.8
7.8
105.13
103.97
mmol/l
0.45
15
91
8
45
1.82
0.86
1.9
1.7
—
—
—
0
0
8
46
1.78
0.84
10.4
10.3
1.44
1.73
%
—
8
46
6
33
1.85
0.80
1.0
1.4
—
—
—
0
0
0
28
0.00
0.77
0.0
1.6
—
—
—
0
0
7
38
1.88
0.74
1.1
2.6
65.80
54.69
%
—
7
38
5
25
2.03
0.73
1.2
1.2
—
—
—
0
0
7
40
1.79
0.72
1.4
3.1
1.14
1.71
%
—
7
40
7
40
1.79
0.72
1.4
1.3
—
—
—
0
0
5
26
1.95
0.71
1.0
1.2
—
2.60
—
0
13
9
58
1.59
0.71
2.4
2.7
1.21
1.22
mmol/l
—
9
51
34
271
1.33
0.69
3.6
3.2
0.00
0.01
estimate
—
9
99
5
27
1.88
0.69
1.2
1.2
—
—
—
0
0
13
86
1.56
0.68
1.2
1.2
67.00
236.81
iu/ml
—
7
38
58
499
1.27
0.67
2.6
2.4
71.54
96.55
ug/l
1.23
49
465
124
1171
1.36
0.66
15.6
12.1
41.63
41.29
%
0.23
88
976
80
882
0.80
0.65
2.9
2.9
62.81
41.57
u/l
0.56
75
849
9
137
0.63
0.64
4.6
1.8
—
—
—
0
0
0
21
0.00
0.60
0.0
2.9
—
—
—
0
0
0
21
0.00
0.60
0.0
4.5
—
1.80
—
0
21
10
65
1.58
0.57
4.0
3.4
5.01
4.74
pmol/l
—
10
57
6
37
1.65
0.56
2.2
2.2
—
—
—
0
0
6
37
1.65
0.56
1.2
4.8
104.00
92.27
%
—
6
37
6
40
1.52
0.52
2.2
2.6
—
—
—
0
0
7
45
1.58
0.49
11.7
10.5
0.79
0.69
%
—
7
45
48
420
1.21
0.46
3.5
3.0
—
—
—
0
0
18
139
1.34
0.46
3.3
2.8
2.51
2.60
e6/l
—
10
75
59
527
1.20
0.46
3.7
3.2
0.00
0.00
estimate
—
10
98
5
32
1.58
0.42
1.8
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
59
532
1.18
0.41
3.8
3.2
0.00
0.00
estimate
—
9
96
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
58
523
1.18
0.40
5.3
4.5
0.00
0.00
estimate
—
10
101
9
66
1.39
0.39
1.6
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
4.8
—
0.00
—
0
19
0
19
0.00
0.39
0.0
4.8
—
0.00
—
0
19
0
19
0.00
0.39
0.0
4.8
—
0.00
—
0
19
8
115
0.68
0.38
4.6
1.7
—
—
—
0
0
18
144
1.28
0.37
3.4
2.7
1.24
0.92
e6/l
0.23
11
79
5
77
0.64
0.37
1.2
1.0
—
—
—
0
0
6
43
1.41
0.35
1.2
1.1
—
—
—
0
0
102
970
1.17
0.34
4.0
4.4
36.94
38.34
mmol/mol
0.84
91
924
7
55
1.29
0.30
1.7
2.0
32.57
113.17
ng/l
—
7
47
16
193
0.81
0.28
1.3
1.2
64.81
28.70
iu/ml
—
10
65
8
63
1.29
0.28
3.9
3.9
29.88
66.02
ng/l
—
8
58
8
65
1.24
0.27
37.6
3.8
5.10
5.05
kpa
—
8
57
18
151
1.22
0.26
2.4
1.9
—
—
—
0
0
29
257
1.16
0.24
3.1
2.6
0.06
0.32
e6/l
1.98
21
190
90
860
1.12
0.23
3.5
3.6
15.10
14.54
pmol/l
1.18
80
797
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
2.58
—
0
11
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
3.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
153.50
—
0
10
100
1035
0.90
0.21
9.6
9.6
101.33
92.25
ml/min/173m2
3.96
78
820
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
7.66
—
0
8
108
1046
1.12
0.21
4.3
4.1
1.91
1.79
mu/l
0.52
97
971
26
232
1.15
0.20
1.9
2.2
0.91
1.16
mg/l
0.20
21
169
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
13
109
1.21
0.19
3.4
3.3
30.38
30.76
%
—
8
76
22
195
1.15
0.19
1.5
1.4
—
—
—
0
0
7
61
1.15
0.18
1.9
1.6
297.71
314.38
mu/l
—
7
56
32
339
0.93
0.10
2.5
3.1
18.61
18.33
ng/l
0.02
18
184
105
1069
0.94
0.09
3.6
3.6
5.53
5.74
mmol/l
1.70
94
994
7
84
0.83
0.07
1.0
1.3
—
—
—
0
0
112
1134
0.95
0.06
3.6
3.8
2.97
2.86
mmol/l
0.52
101
1071
21
199
1.06
0.05
1.2
1.4
17.72
21.36
nmol/l
0.61
15
165
106
1069
0.97
0.02
2.8
3.3
1.41
1.29
mmol/l
0.64
94
1007
121
1202
1.04
0.02
13.0
11.2
22.49
21.19
mg/l
0.21
99
877
11
103
1.07
0.02
2.9
1.7
—
—
—
0
0
11
103
1.07
0.02
2.2
1.6
—
—
—
0
0
113
1122
1.03
0.02
3.4
3.5
4.71
4.73
mmol/l
0.07
102
1064
111
1116
0.98
0.00
3.4
3.5
1.37
1.44
mmol/l
1.29
100
1056
81
812
0.99
0.00
3.8
3.6
9.47
8.88
mm/h
0.22
76
751
19
185
1.03
0.00
3.1
2.6
11.30
116.78
ng/l
—
10
107
136
1362
0.98
0.00
19.9
16.0
138.71
138.99
g/l
0.08
136
1339
18
178
1.01
0.00
4.4
3.8
21.46
21.67
%
—
9
70
5
49
1.02
0.00
1.6
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
133.40
—
0
5
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
3.1
—
18.84
—
0
8
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
7.44
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
6
59
1.02
0.00
2.5
1.7
8.67
4.05
ug/l
—
6
53
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
1154.57
—
0
7
0
8
0.00
0.00
0.0
1.0
—
1398.63
—
0
8
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
5
56
0.89
0.00
1.2
1.4
—
—
—
0
0
7
79
0.88
0.00
2.1
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
4.8
—
23.63
—
0
9
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_HYDROCEPHALUS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_HYDROCEPHALUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_HYDROCEPHALUS – Congenital hydrocephalus
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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