No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
170 |
4. Check minimum number of eventsNone |
170 |
5. Include endpointsNone |
170 |
6. Filter based on genotype QC (FinnGen only) |
142 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_NERVOUS_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- Special
- Q17_HCCONG
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q00-Q07
- Name in latin
- Hydrocephalia congenita
Similar endpoints
↥List of similar endpoints to
Congenital hydrocephalus
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of the nervous system
- Hydrocephalus
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities, including avohilmo
- Other neurological diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2458 | 1124 | 1328 |
| Only index persons | 1790 | 813 | 977 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.04 |
| Only index persons | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 3.23 | 3.70 | 2.57 |
| Only index persons | 3.93 | 5.20 | 2.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 142 | 73 | 69 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 9.94 | 12.86 | 6.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 150
- Matched controls
- 1500
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
46.3
42
*
Q03.9
ICD-10 Finland
Congenital hydrocephalus, unspecified
+∞
46.3
42
*
G91.1
ICD-10 Finland
Obstructive hydrocephalus
514.9
41.2
39
*
7423A
ICD-9 Finland
Other congenital anomalies of nervous system, Congenital hydrocephalus
+∞
37.0
34
*
74200
ICD-8 Finland
Congenital hydrocephalus, Communicans
+∞
35.9
33
*
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
406.3
33.3
32
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
12.5
32.6
36
37
Q03.0
ICD-10 Finland
Malformations of aqueduct of Sylvius
+∞
30.2
28
*
74209
ICD-8 Finland
Congenital hydrocephalus, Unspecified
+∞
30.2
28
*
2133
FHL
Suntin revisio
+∞
26.9
25
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
311.9
26.6
26
*
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
23.6
22
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
+∞
20.3
19
*
2132
FHL
Ventricular operators sunt
+∞
18.1
17
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
71.9
17.2
19
*
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
17.0
16
*
AA1AD
NOMESCO Finland
CT of head and brain
4.4
17.0
60
196
H47.2
ICD-10 Finland
Optic atrophy
+∞
15.9
15
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
14.0
15.3
26
22
G91.8
ICD-10 Finland
Other hydrocephalus
+∞
14.8
14
*
3313A
ICD-9 Finland
Other cerebral degenerations, Communicating hydrocephalus
+∞
14.8
14
*
Q03.1
ICD-10 Finland
Atresia of foramina of Magendie and Luschka
+∞
12.7
12
*
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
+∞
12.7
12
*
74201
ICD-8 Finland
Congenital hydrocephalus, Non communicans
+∞
12.7
12
*
AAF00
NOMESCO Finland
Ventriculostomy
+∞
11.6
11
*
AA1AA
NOMESCO Finland
Head X-ray examination
27.5
11.4
15
6
74210, ,
ICD-8 Finland
+∞
10.5
10
*
3314A
ICD-9 Finland
Other cerebral degenerations, Obstructive hydrocephalus
+∞
10.5
10
*
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
43.2
10.1
12
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.3
9.7
28
76
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
11.8
9.6
17
16
R42
ICD-10 Finland
Dizziness and giddiness
3.4
9.1
39
139
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
8.4
8.5
18
24
Q03.88
ICD-10 Finland
Other congenital hydrocephalus
+∞
8.4
8
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
16.2
7.9
12
8
N03AG01
ATC
valproic acid; systemic, rectal
4.7
7.7
19
45
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.7
7.7
27
84
183
Kela drug reimbursment
Lamotrigin and topiramate
14.4
7.5
12
9
AAF15
NOMESCO Finland
Ventriculoatrial shunt
+∞
7.3
7
*
7410D
ICD-9 Finland
Spina bifida, With hydrocephalus[SPINA BIFIDA APERTA CUM HYDROCEPHALO REG LUMBALIS]
+∞
7.3
7
*
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
42.0
6.8
8
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.5
6.7
17
41
N03AX09
ATC
lamotrigine; oral
4.5
6.7
17
41
XCK00
NOMESCO Finland
Perimetry
6.8
6.7
16
26
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.7
6.6
22
66
N03AF02
ATC
oxcarbazepine; oral
6.3
6.4
16
28
Q05.2
ICD-10 Finland
Lumbar spina bifida with hydrocephalus
+∞
6.3
6
*
2139
FHL
Other measure in this category
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
13
11
12.80
7.74
2.7
1.6
—
—
—
0
0
7
7
10.41
4.05
3.7
2.7
66.86
52.86
umol/l
—
7
7
7
9
8.09
3.60
1.3
1.2
1.75
1.85
mmol/l
—
7
9
72
502
1.84
3.29
6.4
8.6
1.21
1.21
mmol/l
0.04
60
435
20
94
2.30
2.69
6.5
6.7
—
—
—
0
0
0
63
0.00
2.49
0.0
1.6
—
54.53
—
0
54
0
59
0.00
2.30
0.0
1.4
—
0.92
—
0
37
0
59
0.00
2.30
0.0
1.4
—
1.16
—
0
37
0
59
0.00
2.30
0.0
1.4
—
1.06
—
0
37
21
109
2.08
2.24
8.2
12.8
0.34
1.18
mmol/l
0.27
12
91
0
48
0.00
1.73
0.0
1.7
—
—
—
0
0
37
252
1.62
1.67
2.3
2.6
—
—
—
0
0
18
297
0.55
1.57
2.9
2.4
—
—
—
0
0
91
1044
0.67
1.51
3.4
3.6
—
—
—
0
0
18
294
0.56
1.51
2.7
3.9
4.20
11.03
mg/mmol
0.74
13
190
16
270
0.54
1.50
2.7
2.3
—
—
—
0
0
24
361
0.60
1.47
1.3
1.3
0.80
1.22
u/ml
—
6
94
9
44
2.11
1.29
1.1
4.3
110.11
93.68
%
—
9
44
21
132
1.69
1.29
4.8
8.5
104.43
104.39
mmol/l
0.01
21
132
65
525
1.42
1.28
2.7
3.0
—
—
estimate
—
0
0
6
25
2.46
1.25
1.7
1.6
—
—
—
0
0
11
59
1.93
1.10
9.9
12.3
1.25
1.54
%
0.44
11
59
35
259
1.46
1.09
1.7
1.9
2.95
2.85
mg/l
0.06
29
223
27
370
0.67
1.07
1.9
1.6
—
—
—
0
0
13
75
1.80
1.06
1.5
1.6
—
—
—
0
0
15
233
0.60
1.04
1.3
1.2
60.62
5.46
u/ml
—
6
98
43
334
1.40
1.03
3.4
3.4
0.00
0.01
estimate
0.50
13
121
80
688
1.35
1.02
10.7
11.3
4.31
4.02
e9/l
0.53
71
611
5
23
2.21
0.99
2.0
1.4
—
—
—
0
0
9
52
1.78
0.94
1.3
1.2
—
—
—
0
0
9
52
1.78
0.94
1.6
2.8
56.94
48.10
%
—
9
52
11
63
1.81
0.93
16.8
11.0
24.38
24.67
mmol/l
0.08
11
63
6
32
1.91
0.82
1.3
1.3
—
—
—
0
0
10
58
1.78
0.82
10.7
12.4
0.67
0.64
%
—
10
58
10
60
1.71
0.74
1.9
1.6
—
—
—
0
0
37
299
1.32
0.69
4.1
3.2
1.02
1.02
kg/l
0.03
25
189
10
151
0.64
0.63
4.4
2.1
—
—
—
0
0
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
0
23
0.00
0.59
0.0
2.9
—
—
—
0
0
6
35
1.74
0.58
1.7
1.5
—
—
—
0
0
6
35
1.74
0.58
1.2
1.4
—
—
—
0
0
5
89
0.55
0.58
1.4
1.4
—
—
—
0
0
57
497
1.24
0.58
1.8
1.9
1.37
1.41
mmol/l
0.13
52
432
13
90
1.49
0.57
3.8
3.4
—
—
—
0
0
8
55
1.48
0.57
1.8
3.4
1.13
1.51
%
—
8
55
13
91
1.47
0.55
3.8
5.5
5.32
4.53
kpa
0.55
13
91
9
131
0.67
0.54
4.4
2.0
—
—
—
0
0
6
40
1.52
0.52
2.2
2.1
—
—
—
0
0
5
84
0.58
0.47
1.2
1.0
—
—
—
0
0
5
31
1.63
0.43
2.0
1.4
—
—
—
0
0
8
56
1.45
0.43
12.1
10.9
23.45
24.80
mmol/l
—
8
56
5
32
1.58
0.42
1.2
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
208.45
—
0
15
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
20
246
0.78
0.41
1.3
1.3
58.35
26.95
iu/ml
0.34
11
80
12
159
0.73
0.41
2.7
2.4
0.72
0.75
ug/l
—
7
80
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
48
426
1.19
0.39
2.0
1.9
97.64
96.93
pmol/l
0.05
24
221
0
19
0.00
0.39
0.0
1.5
—
—
—
0
0
13
98
1.36
0.39
1.2
1.2
67.00
220.65
u/ml
—
7
43
10
72
1.42
0.38
31.3
3.8
5.07
5.05
kpa
—
10
67
20
163
1.26
0.36
3.7
3.2
2.51
2.54
e6/l
—
10
78
6
43
1.41
0.35
2.2
2.5
—
—
—
0
0
22
183
1.24
0.34
2.6
1.9
—
—
—
0
0
10
75
1.36
0.31
4.9
4.0
4.97
4.64
pmol/l
—
10
66
69
642
1.14
0.30
4.0
3.5
0.00
13.10
estimate
0.50
15
124
7
57
1.24
0.29
1.4
1.5
—
—
—
0
0
23
196
1.20
0.29
1.7
1.6
446.89
456.47
pmol/l
0.07
18
171
69
643
1.14
0.29
4.0
3.6
0.00
0.00
estimate
-0.00
14
120
8
62
1.31
0.28
5.0
6.6
24.54
24.59
mmol/l
—
8
62
68
636
1.13
0.26
3.9
3.5
0.00
0.00
estimate
-0.00
15
125
33
294
1.16
0.26
3.3
2.9
0.06
0.30
e6/l
1.95
23
205
5
38
1.33
0.23
1.0
1.2
—
1.62
—
0
25
5
38
1.33
0.23
3.8
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
149.64
—
0
11
0
10
0.00
0.21
0.0
3.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
1393.90
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
562.90
—
0
10
0
10
0.00
0.21
0.0
1.0
—
9.70
—
0
10
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
6.1
—
30.37
—
0
10
0
12
0.00
0.21
0.0
1.3
—
2.80
—
0
12
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
29
261
1.14
0.20
1.9
2.2
0.94
1.39
mg/l
0.42
24
196
64
605
1.10
0.19
2.9
2.9
75.65
95.27
ug/l
0.87
55
572
111
1140
0.90
0.18
3.3
3.6
1.37
1.29
mmol/l
0.44
101
1081
113
1159
0.90
0.18
5.2
4.9
1.97
1.79
mu/l
0.93
107
1087
7
60
1.17
0.18
2.1
2.2
32.57
112.19
ng/l
—
7
53
20
177
1.15
0.17
3.8
3.0
1.24
0.84
e6/l
0.30
11
90
5
67
0.74
0.17
1.2
1.4
—
—
—
0
0
31
284
1.12
0.16
1.5
1.5
17.21
21.03
nmol/l
0.85
20
240
53
500
1.09
0.16
3.6
3.1
0.00
0.00
estimate
—
9
105
87
899
0.92
0.15
4.3
3.9
9.30
8.78
mm/h
0.21
82
836
7
87
0.80
0.15
1.0
1.3
—
—
—
0
0
23
209
1.12
0.14
1.5
1.5
—
—
—
0
0
139
1406
0.84
0.13
23.8
19.4
138.33
138.89
g/l
0.18
139
1392
9
110
0.81
0.13
1.9
5.6
208.22
243.88
u/l
—
9
110
139
1405
0.85
0.12
24.0
19.7
41.41
41.35
%
0.06
139
1388
139
1404
0.86
0.10
23.2
19.3
89.28
90.08
fl
1.33
139
1390
14
125
1.13
0.10
4.1
3.8
30.63
31.14
%
—
8
87
15
135
1.12
0.10
2.5
1.6
—
—
—
0
0
125
1267
0.92
0.09
15.3
13.1
24.09
20.96
mg/l
0.49
105
988
123
1213
1.08
0.09
4.1
4.3
4.72
4.70
mmol/l
0.08
115
1159
7
67
1.05
0.08
2.1
1.7
305.14
331.72
mu/l
—
7
62
8
78
1.03
0.07
4.4
4.1
31.38
66.32
ng/l
—
8
70
133
1317
1.09
0.07
16.1
15.5
67.87
73.44
umol/l
3.46
133
1302
112
1107
1.05
0.05
4.5
5.0
36.70
37.95
mmol/mol
0.88
104
1059
121
1221
0.95
0.04
4.4
4.6
2.91
2.81
mmol/l
0.56
113
1164
115
1159
0.97
0.02
4.0
4.1
5.60
5.74
mmol/l
0.70
107
1084
113
1139
0.97
0.02
11.6
11.8
99.40
91.34
ml/min/173m2
3.96
98
1035
120
1207
0.97
0.01
4.1
4.2
1.37
1.43
mmol/l
1.00
112
1150
22
214
1.03
0.00
3.5
2.9
119.64
100.25
ng/l
0.06
14
127
24
246
0.97
0.00
2.1
3.4
1722.81
861.02
ng/l
0.41
19
199
97
976
0.98
0.00
4.1
4.1
15.09
14.57
pmol/l
1.32
92
910
39
394
0.99
0.00
2.8
3.2
17.25
18.41
ng/l
0.12
26
233
21
209
1.01
0.00
4.5
3.9
22.05
22.36
%
—
10
81
13
127
1.03
0.00
3.4
1.7
—
—
—
0
0
39
387
1.01
0.00
2.7
2.7
0.00
0.00
estimate
—
9
101
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
11.14
—
0
8
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
43.36
—
0
5
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
88.87
—
0
7
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
4.63
—
0
8
0
5
0.00
0.00
0.0
4.6
—
342.40
—
0
5
0
7
0.00
0.00
0.0
1.1
—
23.10
—
0
7
0
7
0.00
0.00
0.0
1.0
—
73.43
—
0
7
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
0.80
—
0
5
7
79
0.88
0.00
2.1
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
1154.57
—
0
7
0
9
0.00
-0.00
0.0
3.4
—
13.28
—
0
9
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
7.25
—
0
6
8
80
1.00
-0.00
1.0
1.1
1.51
1.53
g/l
—
8
80
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
220.00
—
0
6
6
61
0.98
-0.00
2.7
1.8
8.73
4.08
ug/l
—
6
54
8
81
0.99
-0.00
1.0
1.1
0.86
0.87
g/l
—
8
81
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_HYDROCEPHALUS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_HYDROCEPHALUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_HYDROCEPHALUS – Congenital hydrocephalus
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data