Intracranial nontraumatic haemorrhage of fetus and newborn

P16_INTRACR_NONTRAU_HAEMORRHAGE_FETUS_NEWBO

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P52 Cause of death: ICD-10 — P52 2 out of 7 registries used, show all original rules.	54
4. Check minimum number of events None	54
5. Include endpoints None	54
6. Filter based on genotype QC (FinnGen only)	49

Control definitions (FinnGen only)

Control exclude: P16_HAEMORRHAGIC_HAEMATOL_DISORD_FETUS_NEWBO

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P[5-6]
Name in latin: Haemorrhagia intracranialis non traumatica fetus sive neonati

NAME	P16_INTRACR_NONTRAU_HAEMORRHAGE_FETUS_NEWBO
CONTROL_EXCLUDE	P16_HAEMORRHAGIC_HAEMATOL_DISORD_FETUS_NEWBO
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P52
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P52
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Intracranial nontraumatic haemorrhage of fetus and newborn based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2780	1110	1670
Only index persons	1118	439	679
Unadjusted period prevalence (%)
Whole population	0.04	0.03	0.05
Only index persons	0.02	0.02	0.03
Median age at first event (years)
Whole population	-	0.00	0.00
Only index persons	0.00	0.00	0.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	49	27	22
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	0.00	0.00	0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
51: Matched controls
510

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

Z87.6

ICD-10 Finland

Personal history of certain conditions arising in the perinatal period

45.1

25.5

P52.0

ICD-10 Finland

Intraventricular (nontraumatic) haemorrhage, grade 1, of fetus and newborn

+∞

20.1

P52.2

ICD-10 Finland

Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn

+∞

16.5

P07.2

ICD-10 Finland

Extreme immaturity

+∞

16.5

P07.3

ICD-10 Finland

Other preterm infants

28.6

15.5

P27.1

ICD-10 Finland

Bronchopulmonary dysplasia originating in the perinatal period

+∞

15.4

P22.0

ICD-10 Finland

Respiratory distress syndrome of newborn

188.1

14.2

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

9.8

13.7

602

Kela drug reimbursment

Children's severe malnutrition

16.6

13.2

R4110

NOMESCO Finland

Physiotherapy

8.0

12.4

102

AA7AA

NOMESCO Finland

Liquor cerebri shunt X-ray examinatin without contrast

153.2

12.0

AAF05

NOMESCO Finland

Ventriculoperitoneal shunt

137.1

10.9

AAF20

NOMESCO Finland

Revision of shunt of ventricle of brain

137.1

10.9

P59.0

ICD-10 Finland

Neonatal jaundice associated with preterm delivery

+∞

10.8

Z2446

NOMESCO Finland

Social worker

6.6

10.4

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

12.5

10.3

AA5HE

NOMESCO Finland

Brain ultrasound examination in a child

11.9

10.0

R1230

NOMESCO Finland

Neuropsychological evaluation of need and possibilities to rehabilitation

11.9

10.0

G91.1

ICD-10 Finland

Obstructive hydrocephalus

121.7

9.8

H35.1

ICD-10 Finland

Retinopathy of prematurity

+∞

9.7

G40.9

ICD-10 Finland

Epilepsy, unspecified

45.6

9.4

F82

ICD-10 Finland

Specific developmental disorder of motor function

17.0

9.0

G91.0

ICD-10 Finland

Communicating hydrocephalus

107.0

8.7

P52.4

ICD-10 Finland

Intracerebral (nontraumatic) haemorrhage of fetus and newborn

+∞

8.6

WX882

NOMESCO Finland

High dependency care

5.9

8.5

AA1AG

NOMESCO Finland

Short MRI examination of brain with median intensity magnet

53.5

8.0

R2130

NOMESCO Finland

Counselling and guidance which enhance independent living

5.5

7.9

N05BA01

ATC

diazepam; systemic, rectal

16.9

7.9

H47.2

ICD-10 Finland

Optic atrophy

93.1

7.6

ZXD05

NOMESCO Finland

Urgent procedure

5.3

7.6

P07.02

ICD-10 Finland

Extremely low birth weight 750-999 g

+∞

7.5

ZXE10

NOMESCO Finland

More than one and less than three hours

4.9

7.4

101

ZXA10

NOMESCO Finland

Bilateral

5.9

7.4

WW804

NOMESCO Finland

Transfer from treating institution to higher-Level care, accompanied by doctor

35.6

7.4

J18.9

ICD-10 Finland

Pneumonia, unspecified

5.3

7.4

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

9.6

7.4

TPH04

NOMESCO Finland

Cathetrisation of vein

5.3

7.2

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

5.1

7.0

P29.30

ICD-10 Finland

Delayed closure of the ductus arteriosus

46.4

7.0

WX730

NOMESCO Finland

Conventional respirator

46.4

7.0

WX408

NOMESCO Finland

General anesthesy, balanced

4.7

6.9

119

Z2221

NOMESCO Finland

Medical doctor

4.7

6.8

Z3226

NOMESCO Finland

Physiotherapist

4.5

6.6

102

P07.10

ICD-10 Finland

Other low birth weight 1000-1499 g

79.4

6.6

R03BB01

ATC

ipratropium bromide; inhalant

79.4

6.6

N05BA09

ATC

clobazam; oral

21.4

6.5

N03AG01

ATC

valproic acid; systemic, rectal

10.8

6.5

AA1AD

NOMESCO Finland

CT of head and brain

9.3

6.4

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

7.0

6.4

G91.9

ICD-10 Finland

Hydrocephalus, unspecified

+∞

6.4

P52.1

ICD-10 Finland

Intraventricular (nontraumatic) haemorrhage, grade 2, of fetus and newborn

+∞

6.4

182

Kela drug reimbursment

Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide

13.4

6.1

Z01.0

ICD-10 Finland

Examination of eyes and vision

4.4

6.1

ZXD10

NOMESCO Finland

Scheduled procedure

4.2

6.0

122

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

10.42

5.91

4.3

1.0

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

6.33

5.06

4.4

8.1

638.85

455.88

mg/l

0.30

(3023368) Bacteria identified in Blood by Culture

3.68

4.58

8.7

4.8

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

8.82

4.57

3.7

1.2

—

(3044290) Cell count panel - Cerebral spinal fluid

5.94

4.54

4.8

8.5

—

(3022313) Gas panel - Capillary blood

130

3.29

4.20

29.6

10.1

—

(3023410) Appearance of Cerebral spinal fluid

5.79

4.16

4.8

9.2

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

147

3.26

4.12

30.2

10.1

0.92

0.78

mmol/l

0.11

113

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

6.26

4.07

3.0

2.2

—

(42870588) Differential panel, method unspecified - Blood

230

3.56

3.95

12.5

15.4

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

5.31

3.90

4.4

8.4

3.11

3.25

mmol/l

0.16

(3042936) Bacteria identified in Isolate by Culture

3.82

3.88

2.4

1.5

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

6.18

3.70

3.1

2.4

—

(3016018) Differential panel - Cerebral spinal fluid

6.18

3.70

4.4

8.4

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

4.90

3.66

3.0

2.3

—

(3013115) Eosinophils [#/volume] in Blood

300

3.76

3.60

12.6

14.7

0.20

0.24

e9/l

0.54

241

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

5.82

3.56

3.6

2.4

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

3.56

3.52

2.9

2.5

675.57

194.90

u/l

0.87

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

141

2.94

3.50

31.7

10.0

23.56

24.08

mmol/l

0.47

141

(3020393) Adenovirus Ag [Presence] in Stool

6.55

3.49

2.3

2.6

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

4.54

3.44

3.0

2.3

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

3.62

3.43

5.6

12.4

2.38

2.67

g/l

0.60

(3022229) Phosphate [Moles/volume] in Urine

9.50

3.35

3.0

6.1

18.87

13.67

mmol/l

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

7.17

3.30

1.4

10.2

105.29

85.09

—

(44790047) Parainfluenza type 1 nucleic acid detection

4.52

3.18

1.8

2.3

—

(44790048) Parainfluenza type 2 nucleic acid detection

4.52

3.18

1.8

2.3

—

(44790049) Parainfluenza type 3 nucleic acid detection

4.52

3.18

1.8

2.3

—

(44806118) Parainfluenza type 4 nucleic acid detection

4.52

3.18

1.8

2.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

3.13

3.17

2.9

1.4

94.00

96.11

pmol/l

—

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

8.30

3.14

4.5

8.3

19.90

9.71

mg/l

—

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

8.30

3.14

1.2

1.6

74.83

95.38

—

(3013005) Retinol [Moles/volume] in Serum or Plasma

6.56

3.13

4.1

4.3

1.36

1.46

umol/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.19

3.13

3.5

2.3

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

7.37

2.95

1.2

—

(4195642) Thrombophilia screening test

9.06

2.81

1.2

1.3

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

6.62

2.78

6.7

3.6

471.67

391.90

umol/l

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

6.62

2.78

2.5

1.0

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

6.62

2.78

2.5

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.14

2.73

2.4

1.5

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.14

2.73

2.4

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.08

2.69

3.6

2.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.08

2.69

3.5

2.4

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

6.01

2.62

2.7

1.0

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

3.10

2.57

6.2

11.5

111.08

167.70

3.71

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

2.89

2.56

5.4

10.3

82.14

90.64

0.50

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.59

2.53

4.2

4.5

—

(3044640) Blood type and Crossmatch panel - Blood

111

2.52

2.49

4.8

4.4

—

(3021960) Folate [Moles/volume] in Serum or Plasma

3.03

2.48

1.6

1.3

26.10

19.60

nmol/l

—

(3013512) EKG study

3.30

2.37

1.7

1.9

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

4.33

2.34

1.0

1.3

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

4.09

2.24

1.9

2.4

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

3.11

2.22

1.1

2.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

3.11

2.22

2.4

1.3

—

(3021589) Normoblasts [#/volume] in Blood

294

2.67

2.20

14.6

15.1

0.00

0.05

e9/l

0.46

209

(3006315) Basophils [#/volume] in Blood

295

2.65

2.17

12.3

13.4

0.04

e9/l

0.05

229

(3001604) Monocytes [#/volume] in Blood

295

2.65

2.17

12.3

13.4

0.54

0.58

e9/l

0.62

229

(3019198) Lymphocytes [#/volume] in Blood

300

2.55

2.01

12.4

13.3

2.20

2.71

e9/l

1.57

244

(3007853) Bacteria identified in Skin by Aerobe culture

2.50

1.99

3.3

1.6

—

(3044889) 12 lead EKG panel

140

2.17

1.89

2.2

1.9

—

(3000991) Gas panel - Venous blood

132

2.17

1.87

15.4

13.6

—

(3000494) Fungus identified in Specimen by Culture

2.78

1.76

2.0

1.6

—

(40758558) Short blood count panel - Blood

199

2.06

1.70

9.5

10.9

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.77

1.68

1.3

2.5

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.77

1.68

1.3

2.5

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

3.26

1.63

2.0

1.5

—

(1761868) Lipid panel - Serum or Plasma

2.42

1.58

2.0

1.6

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

3.57

1.56

2.2

1.6

—

(3026008) Bacteria identified in Urine by Culture

2.10

1.56

10.4

3.1

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

176

1.97

1.54

3.5

2.9

0.90

1.11

mmol/l

1.83

167

(3022145) Colonoscopy Study observation

3.34

1.47

1.6

1.7

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.32

1.45

7.6

23.7

108.36

105.93

mmol/l

1.08

(3013650) Neutrophils [#/volume] in Blood by Automated count

308

2.13

1.45

13.9

15.2

3.08

3.34

e9/l

0.33

242

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.19

1.44

1.4

1.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

144

1.93

1.41

4.7

4.2

—

estimate

—

(4035726) Immunohistochemistry procedure

2.96

1.31

2.0

1.7

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.96

1.31

2.0

1.6

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.66

1.18

1.2

3.9

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.89

1.04

9.2

4.2

—

(3012544) pH of Venous blood

138

1.74

1.03

13.6

16.0

7.38

7.37

0.35

(3024354) Oxygen [Partial pressure] in Venous blood

139

1.72

1.00

13.6

15.4

5.49

5.30

kpa

0.15

139

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.29

0.95

2.0

1.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

171

1.63

0.88

46.3

19.3

24.78

24.73

mmol/l

0.03

171

(3037467) Urinalysis macro (dipstick) panel - Urine

259

1.63

0.86

10.5

4.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

230

1.60

0.84

2.0

2.2

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

138

1.60

0.78

12.5

14.2

24.00

23.16

mmol/l

1.03

138

(21494815) CD4 cells/Lymphocytes in Specimen

2.20

0.77

4.0

6.2

35.94

39.84

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

2.20

0.77

4.0

6.4

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.80

0.75

4.0

6.0

11.14

7.80

g/l

—

(3027831) CD3-CD16+CD56+ (Natural killer) cells/cells in Blood

2.11

0.75

3.8

6.2

14.80

9.04

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.11

0.75

1.0

—

(1175426) CD3 cells/Lymphocytes in Blood

2.11

0.75

4.0

6.1

64.20

71.48

—

(3030467) Casts [#/volume] in Urine by Automated count

158

1.56

0.74

16.3

5.5

1.17

0.14

e6/l

0.49

112

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.87

0.68

1.8

34.7

0.56

0.52

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.87

0.68

6.4

2.5

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.87

0.68

16.8

18.1

23.00

23.70

mmol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

172

1.49

0.63

15.7

5.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

126

1.52

0.62

6.4

4.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.61

0.0

1.8

—

(3011897) Casein IgE Ab [Units/volume] in Serum

0.00

0.61

0.0

2.6

—

4.77

—

(3018095) Leukocytes [#/volume] in Urine

192

1.47

0.61

18.3

6.8

91.16

26.30

e6/l

0.39

127

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

488

+∞

0.61

40.1

22.8

39.03

38.66

0.22

482

(3024731) MCV [Entitic mean volume] in Red Blood Cells

488

+∞

0.61

38.4

20.3

85.89

84.94

0.69

482

(3000963) Hemoglobin [Mass/volume] in Blood

488

+∞

0.61

39.2

20.7

130.82

129.70

g/l

0.18

482

(3035941) MCH [Entitic mass]

488

+∞

0.61

38.4

20.3

29.01

28.57

0.84

482

(40768797) Stomach Pathology biopsy report

1.81

0.60

2.0

1.4

—

(36304419) Bacteria [Presence] in Urine

155

1.48

0.59

16.4

5.5

—

estimate

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

111

1.50

0.55

11.1

5.6

2.00

1.58

e6/l

—

(3015736) pH of Urine

168

1.43

0.52

5.8

3.9

6.80

6.45

—

(3002582) Erythrocytes [#/volume] in Urine

168

1.43

0.52

15.9

5.4

17.71

51.61

e6/l

0.86

123

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.41

0.0

1.9

—

(3015076) Soybean IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.5

—

2.61

—

(40768804) Tissue Pathology biopsy report

1.48

0.40

1.8

1.7

—

(3037522) Nuclear Ab [Titer] in Serum

1.48

0.37

1.2

1.5

—

(3014051) Protein [Presence] in Urine by Test strip

129

1.35

0.36

6.6

3.6

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

112

1.34

0.33

11.6

5.7

1.67

0.53

e6/l

—

(3019150) Specific gravity of Urine by Refractometry

1.34

0.29

1.8

2.8

1.02

kg/l

—

(3022670) pH of Venous cord blood

0.00

0.21

0.0

1.0

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.21

0.0

1.5

—

(3007566) Smooth muscle Ab [Titer] in Serum

0.00

0.21

0.0

1.5

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.5

—

36.30

—

(3022493) Free Hemoglobin [Mass/volume] in Plasma

0.00

0.21

0.0

2.6

—

77.40

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

2.0

—

0.73

—

(3024471) HLA-A [Type]

0.00

0.21

0.0

1.0

—

(3024932) HLA-DR beta [Type]

0.00

0.21

0.0

1.0

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.21

0.0

1.8

—

0.68

—

(3027944) Amphetamines [Presence] in Urine

1.23

0.20

1.2

1.8

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.6

—

5.11

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.20

0.0

1.0

—

(3000764) Benzodiazepines [Presence] in Urine

1.20

0.20

1.2

1.7

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.27

0.19

1.0

1.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.13

0.16

2.1

1.8

—

(3003694) ABO and Rh group [Type] in Blood

143

1.17

0.13

1.9

1.6

—

(36660697) Celiac disease serology panel - Serum

115

0.84

0.12

1.1

1.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.15

0.10

1.2

1.7

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

1.05

0.09

7.8

5.1

18.80

22.09

nmol/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.13

0.08

1.6

1.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.07

0.08

2.4

2.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.85

0.08

2.2

2.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

108

1.15

0.08

2.0

2.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

187

1.11

0.08

4.0

3.4

32.71

35.17

mmol/mol

0.94

174

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

426

0.92

0.07

4.5

3.9

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

269

1.09

0.05

5.1

5.0

7.26

7.06

mm/h

0.04

250

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

171

1.08

0.04

2.6

2.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

222

0.98

0.00

2.1

2.0

1.66

1.33

g/l

1.09

102

(3016879) Cocaine [Presence] in Urine

0.98

0.00

1.2

1.7

—

(3028300) Cannabinoids [Presence] in Urine

0.98

0.00

1.2

1.8

—

(3027008) Opiates [Presence] in Urine

0.98

0.00

1.2

1.7

—

(3007302) Hemoglobin [Mass/volume] in Mixed venous blood

0.00

-0.00

0.0

2.0

—

98.20

—

(21494429) FMR1 gene CGG repeat analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(40761873) Peanut recombinant (rAra h) 1 IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

59.67

—

(40761871) Peanut recombinant (rAra h) 3 IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

-0.00

0.0

7.5

—

1.74

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.96

-0.00

2.1

2.6

—

(3038071) Oxygen [Partial pressure] in Mixed venous blood

0.00

-0.00

0.0

3.8

—

4.90

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

2.2

—

7.16

—

(3026820) Hemoglobin [Mass/volume] in Venous cord blood

0.00

-0.00

0.0

1.0

—

175.71

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

-0.00

0.0

2.0

—

5.80

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

-0.00

0.0

1.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.91

-0.00

2.3

2.8

—

(3027135) IgG subclass 1 [Mass/volume] in Serum

0.00

-0.00

0.0

1.4

—

5.17

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.2

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.4

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

-0.00

0.0

7.0

—

(3023659) Complement C1 esterase inhibitor.functional/Complement C1 esterase inhibitor.total in Serum or Plasma

0.00

-0.00

0.0

1.0

—

112.50

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

-0.00

0.0

1.0

—

(3016031) Almond IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

3.39

—

(21494262) English walnut recombinant (rJug r) 3 IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

1.01

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

3.8

—

(3042733) HLA Ab [Presence] in Serum

0.00

-0.00

0.0

2.6

—

(3028192) IgG subclass 2 [Mass/volume] in Serum

0.00

-0.00

0.0

1.4

—

2.45

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.1

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.95

-0.00

2.4

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

-0.00

0.0

3.4

—

(1175556) inFLIXimab Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

10.4

—

(3021513) Carbon dioxide [Partial pressure] in Mixed venous blood

0.00

-0.00

0.0

3.8

—

6.08

—

(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk

0.00

-0.00

0.0

1.0

—

2.40

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

-0.00

0.0

1.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint P16_INTRACR_NONTRAU_HAEMORRHAGE_FETUS_NEWBO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_INTRACR_NONTRAU_HAEMORRHAGE_FETUS_NEWBO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: P16_INTRACR_NONTRAU_HAEMORRHAGE_FETUS_NEWBO – Intracranial nontraumatic haemorrhage of fetus and newborn

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Intracranial nontraumatic haemorrhage of fetus and newborn

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints