Other fibroblastic disorders

M13_FIBROBLASTNAS

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M72.8, M72.9 Hospital discharge: ICD-9 — 7287X Cause of death: ICD-10 — M72.8, M72.9 Cause of death: ICD-9 — 7287X 2 out of 7 registries used, show all original rules.	157
4. Check minimum number of events None	157
5. Include endpoints None	157
6. Filter based on genotype QC (FinnGen only)	139

Control definitions (FinnGen only)

Control exclude: M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	M13_FIBROBLASTNAS
CONTROL_EXCLUDE	M13_SOFTTISSUE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M72[8-9]
HD_ICD_9	7287X
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M72[8-9]
COD_ICD_9	7287X
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other fibroblastic disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1061	528	526
Only index persons	957	489	468
Unadjusted period prevalence (%)
Whole population	0.01	0.02	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	51.89	50.70	52.89
Only index persons	50.79	49.57	52.07

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	139	73	66
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	51.13	48.34	54.23

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
144: Matched controls
1440

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M72.9

ICD-10 Finland

Fibroblastic disorder, unspecified

+∞

77.2

M72.8

ICD-10 Finland

Other fibroblastic disorders

+∞

47.6

7287X

ICD-9 Finland

Disorders of muscle, ligament and fascia, Other fibromatoses[FIBROMATOSIS ALIA MUSCULI,LIGAMENTI ET FASCIAE]

+∞

40.6

NDM10

NOMESCO Finland

Palmar fasciotomy of hand

+∞

32.5

M72.0

ICD-10 Finland

Palmar fascial fibromatosis [Dupuytren]

105.9

31.3

M72.2

ICD-10 Finland

Plantar fascial fibromatosis

10.9

25.1

M79.6

ICD-10 Finland

Pain in limb

3.6

12.8

352

N03AX12

ATC

[U] gabapentin; oral

4.5

12.3

100

9476

FHL

Splitting of fascia or aponeurosis

+∞

10.5

M75.1

ICD-10 Finland

Rotator cuff syndrome

3.5

9.2

133

NHM10

NOMESCO Finland

Fasciotomy of ankle or foot

95.4

8.5

G72.9

ICD-10 Finland

Myopathy, unspecified

35.5

8.2

ZXA05

NOMESCO Finland

Left side

3.1

8.0

176

M01AX17

ATC

nimesulide; oral

3.0

7.7

192

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.6

7.6

403

ZXE00

NOMESCO Finland

One hour or less

2.7

7.5

341

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

4.3

7.0

M54.5

ICD-10 Finland

Low back pain

2.6

6.9

304

ZXE10

NOMESCO Finland

More than one and less than three hours

2.5

6.6

326

L17

ICPC

Foot/toe symptom/complaint

2.6

6.6

258

M25.5

ICD-10 Finland

Pain in joint

2.6

6.6

258

X59

ICD-10 Finland

Exposure to unspecified factor

3.0

6.5

136

N02AX02

ATC

tramadol; systemic, rectal

2.5

6.4

377

N06AA09

ATC

amitriptyline; systemic

3.9

6.4

QCB10

NOMESCO Finland

Major dressing of wound of skin of upper limb

13.3

6.2

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.5

6.0

237

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.22

4.64

5.8

5.9

25.63

25.14

mmol/l

0.19

(3000991) Gas panel - Venous blood

2.79

4.30

8.0

7.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.34

4.23

1.9

1.8

—

(3000012) Reticulocyte production index

5.57

3.90

1.7

2.7

1.00

0.90

—

(3007164) IgA [Mass/volume] in Serum or Plasma

222

2.04

3.30

1.6

1.9

2.32

g/l

0.01

132

(4062490) Immunoglobulin typing, IgG

8.87

3.29

1.5

1.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

249

1.97

3.16

1.3

1.2

0.56

0.75

u/ml

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

351

1.81

2.81

3.1

2.0

239.25

244.87

u/l

0.02

329

(3026493) Urate [Moles/volume] in Serum or Plasma

295

1.82

2.69

2.7

3.0

342.85

347.77

umol/l

0.10

259

(3021440) Promyelocytes/Leukocytes in Blood

108

2.22

2.69

5.8

5.3

0.00

0.13

—

(3023520) Reticulocytes [#/volume] in Blood

108

2.22

2.69

2.2

3.3

83.58

68.83

e9/l

0.71

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

530

1.72

2.60

7.3

7.0

1.21

1.22

mmol/l

0.51

494

(3019977) pH of Arterial blood

132

2.08

2.56

6.5

11.0

7.41

7.42

0.28

(3014007) Fractional oxyhemoglobin in Arterial blood

2.45

2.52

7.9

8.7

91.27

93.04

0.35

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

4.54

2.50

2.1

3.0

33.14

32.75

—

(3012544) pH of Venous blood

119

2.11

2.48

4.8

2.9

7.39

7.40

0.14

(3013826) Glucose [Moles/volume] in Serum or Plasma

691

1.70

2.45

5.0

5.5

7.02

6.70

mmol/l

0.53

659

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

181

1.91

2.40

1.2

2.16

18.01

u/ml

2.03

(3017181) Myelocytes/Leukocytes in Blood

114

2.10

2.36

5.8

5.2

0.33

0.89

—

(3002179) Metamyelocytes/Leukocytes in Blood

107

2.13

2.35

6.0

5.3

0.00

0.61

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.03

2.28

1.4

1.1

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.03

2.28

1.4

1.1

—

(3009261) Glucose [Presence] in Urine by Test strip

630

1.65

2.27

5.3

3.4

0.18

0.00

estimate

0.48

129

(3021601) Nitrite [Presence] in Urine by Test strip

621

1.65

2.26

5.0

3.3

0.00

estimate

-0.00

138

(3023368) Bacteria identified in Blood by Culture

319

1.70

2.22

6.4

4.4

—

(3035715) Granulocytes [#/volume] in Blood

3.82

2.18

2.1

2.5

3.35

4.20

e9/l

—

(3035350) Ketones [Presence] in Urine by Test strip

625

1.63

2.17

5.3

3.3

0.00

estimate

-0.00

143

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

3.03

2.11

1.3

1.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.35

2.08

2.8

2.1

0.79

0.62

1.06

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

281

1.70

2.07

2.4

1.9

2.88

3.17

mg/l

0.46

238

(3031040) Bacteria [#/volume] in Urine by Automated count

770

1.64

2.06

5.7

3.9

—

134.20

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

192

1.78

1.99

1.9

—

(3035933) Granulocytes/Leukocytes in Blood

2.84

1.97

1.9

2.1

58.22

58.54

—

(3022145) Colonoscopy Study observation

130

1.92

1.96

1.6

1.4

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

329

1.64

1.94

2.0

3.4

4391.63

1254.93

ng/l

0.83

278

(3048689) Calprotectin [Mass/mass] in Stool

124

1.91

1.89

3.4

2.8

49.13

157.54

ug/g

1.89

(36660697) Celiac disease serology panel - Serum

2.13

1.88

1.3

1.2

—

(1761868) Lipid panel - Serum or Plasma

546

0.61

1.88

3.7

3.1

—

(3015736) pH of Urine

487

1.57

1.86

4.7

3.0

6.23

6.14

0.31

277

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.67

1.83

1.6

1.1

0.19

0.22

g/l

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

205

1.72

1.83

1.5

1.2

25.51

42.72

iu/ml

0.80

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

125

1119

1.89

1.82

5.8

5.0

1.90

1.96

mu/l

0.20

118

1032

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

594

1.55

1.81

7.9

8.2

1.21

mmol/l

0.04

512

(21494755) Public health laboratory ask at order entry panel

147

0.38

1.77

1.0

1.4

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

107

923

1.62

1.74

7.7

8.2

77.79

81.11

u/l

0.45

100

872

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.14

1.71

7.9

8.7

0.52

0.72

0.80

(3025159) Blasts/Leukocytes in Blood

113

1.89

1.71

6.3

5.7

0.00

0.23

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

2.35

1.68

1.4

1.1

—

1.63

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

170

1.72

1.64

4.6

2.7

3.09

2.64

e6/l

0.12

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

3.66

1.63

1.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.59

1.62

1.9

1.4

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

415

1.53

1.61

2.2

3.4

2.35

2.36

mmol/l

0.16

385

(3019198) Lymphocytes [#/volume] in Blood

614

1.50

1.61

8.5

6.1

1.83

1.85

e9/l

0.09

553

(3029937) Albumin [Presence] in Urine by Test strip

343

1.55

1.60

4.5

3.4

0.00

0.01

estimate

0.50

137

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.08

1.60

7.4

8.5

1.26

1.57

0.62

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.13

1.60

2.8

2.1

1.04

1.21

0.47

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

510

1.50

1.58

2.4

2.0

101.84

98.48

pmol/l

0.17

251

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

140

1.77

1.57

1.4

2.0

1.46

1.50

0.11

122

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

133

1.77

1.53

2.0

1.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.94

1.53

1.6

3.4

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.93

1.52

1.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

467

1.49

1.50

4.5

3.4

0.00

estimate

-0.00

118

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.31

1.50

1.1

1.0

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

2.13

1.48

1.0

1.3

—

41.57

—

(42870588) Differential panel, method unspecified - Blood

385

1.50

1.47

7.3

6.1

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

102

885

1.52

1.47

5.1

3.9

14.48

11.71

mm/h

0.62

823

(4281824) Cell count and differential, peritoneal fluid

3.20

1.45

1.0

1.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

193

1.63

1.44

4.5

2.4

1.21

1.24

e6/l

0.03

103

(3007853) Bacteria identified in Skin by Aerobe culture

120

1.77

1.43

3.3

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

144

1.71

1.43

1.9

1.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

107

941

1.53

1.42

4.5

4.1

14.83

14.91

pmol/l

0.11

101

861

(3013650) Neutrophils [#/volume] in Blood by Automated count

685

1.46

1.40

9.3

11.2

4.45

4.06

e9/l

0.63

604

(3006315) Basophils [#/volume] in Blood

607

1.45

1.39

8.6

6.2

0.03

0.04

e9/l

1.42

530

(3019230) Fractional oxyhemoglobin in Venous blood

2.68

1.38

4.5

1.3

55.67

62.71

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.68

1.38

1.5

1.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

265

1.53

1.35

1.7

1.5

0.82

1.42

mg/l

1.19

213

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

523

1.44

1.34

2.8

—

estimate

—

(3013115) Eosinophils [#/volume] in Blood

631

1.43

1.32

8.5

6.5

0.15

0.19

e9/l

2.47

559

(1616796) Gas panel - Central venous blood

2.56

1.32

3.3

3.1

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.43

1.31

2.4

1.6

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.08

1.31

3.3

2.1

—

(3026008) Bacteria identified in Urine by Culture

348

1.47

1.30

4.8

2.7

—

(40768804) Tissue Pathology biopsy report

469

1.44

1.29

1.8

2.1

—

(3021589) Normoblasts [#/volume] in Blood

546

1.42

1.27

13.6

12.2

0.00

0.01

e9/l

0.30

455

(3019309) Folate [Moles/volume] in Red Blood Cells

191

1.58

1.26

1.7

1043.33

1225.75

nmol/l

0.63

134

(3001604) Monocytes [#/volume] in Blood

605

1.42

1.26

8.6

6.2

0.58

0.60

e9/l

0.26

531

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

129

1196

1.75

1.24

21.0

14.4

26.78

24.19

mg/l

0.32

101

960

(40760892) CBC W Ordered Manual Differential panel - Blood

270

1.50

1.24

7.7

5.7

—

(3032080) INR in Blood by Coagulation assay

548

1.42

1.24

14.7

11.8

1.16

1.22

inr

0.51

449

(3000494) Fungus identified in Specimen by Culture

150

1.63

1.24

1.3

1.5

—

(40761536) Microorganisms panel - Urine sediment

1.79

1.23

3.6

3.5

—

(3018418) pH of Serum or Plasma

379

1.44

1.23

5.8

4.1

7.40

0.13

285

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

280

1.49

1.22

2.8

2.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.40

1.14

1.7

1.3

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

232

1.49

1.10

5.2

3.5

1033.15

236.66

ng/l

0.47

188

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.78

1.09

1.7

1.5

—

(3019150) Specific gravity of Urine by Refractometry

268

1.46

1.09

5.3

3.3

1.02

kg/l

0.09

177

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.72

1.05

1.5

1.6

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

1.97

1.04

1.4

1.2

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.32

1.04

1.6

1.1

—

(3027315) Oxygen [Partial pressure] in Blood

2.32

1.04

4.4

3.0

11.34

8.45

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.32

1.04

4.4

3.0

5.08

5.07

kpa

—

(3019060) Gas panel - Arterial blood

1.83

1.04

3.3

10.9

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

192

1.50

1.02

2.0

—

(3010421) pH of Blood

2.05

1.01

3.6

3.2

7.41

7.42

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

117

1.62

0.99

3.8

3.7

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.98

0.0

1.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

169

1.50

0.95

1.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.67

0.95

1.8

2.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

414

1.36

0.94

4.5

2.9

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

2.19

0.92

1.2

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

137

1.53

0.90

1.7

—

(3049717) Cytology report of Urine Cyto stain

1.91

0.89

2.4

3.0

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.04

0.88

1.3

1.2

—

(3002582) Erythrocytes [#/volume] in Urine

391

1.34

0.86

4.3

2.8

20.57

110.50

e6/l

1.44

292

(3030467) Casts [#/volume] in Urine by Automated count

337

1.35

0.83

4.5

2.6

0.17

0.38

e6/l

1.21

240

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.69

0.77

1.3

—

(3011288) Drugs identified in Urine by Screen method Nominal

1.80

0.77

1.0

1.7

—

(40768443) Skin Pathology biopsy report

1.71

0.76

1.6

1.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

360

1.32

0.76

3.6

2.9

0.00

estimate

-0.00

108

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

1.88

0.75

1.3

5.2

—

3.41

—

(40768797) Stomach Pathology biopsy report

161

1.43

0.74

1.2

—

(3037522) Nuclear Ab [Titer] in Serum

144

1.45

0.73

2.0

1.3

1576.00

330.00

titre

—

(4034850) Laboratory test

1.79

0.72

17.6

7.6

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

1.96

0.71

1.4

1.7

55.60

72.23

pmol/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

163

1.41

0.69

1.6

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.88

0.69

1.2

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.88

0.69

1.2

1.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

461

1.27

0.67

3.6

3.7

58.71

30.73

ng/l

0.50

314

(40758558) Short blood count panel - Blood

367

1.29

0.66

3.9

6.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

104

1.49

0.65

1.9

2.1

—

(3044640) Blood type and Crossmatch panel - Blood

381

1.26

0.59

3.0

2.4

—

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

1.53

0.59

2.3

2.6

67.71

57.93

ml/min/173m2

—

(3037756) Immunofixation for Serum or Plasma

1.74

0.58

1.0

1.8

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.74

0.58

1.7

2.0

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

260

1.30

0.58

1.9

1.8

477.81

50431463.63

pmol/l

0.50

232

(3014576) Chloride [Moles/volume] in Serum or Plasma

160

1.37

0.57

7.3

6.1

100.52

104.53

mmol/l

3.53

160

(3042936) Bacteria identified in Isolate by Culture

169

1.36

0.57

2.8

2.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

716

1.23

0.56

3.0

2.9

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.56

0.53

1.0

1.3

—

(4024509) Urine culture

1.56

0.53

1.5

1.8

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.41

0.51

7.1

3.7

3.51

2.59

mmol/l

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

143

0.68

0.50

2.6

2.1

3.51

3.55

ratio

—

116

(3009508) Creatinine [Moles/volume] in Urine

418

1.22

0.49

3.7

3.1

7.07

7.50

mmol/l

0.32

355

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

1.51

0.48

1.7

2.1

0.36

0.99

ug/l

—

(3021960) Folate [Moles/volume] in Serum or Plasma

343

1.23

0.47

1.8

1.6

20.66

21.07

nmol/l

0.06

290

(40761511) CBC panel - Blood by Automated count

130

1255

1.37

0.46

16.3

13.4

—

(3018095) Leukocytes [#/volume] in Urine

459

1.21

0.46

6.2

3.2

100.62

82.08

e6/l

0.13

312

(40761535) Cells panel - Urine sediment

1.44

0.44

4.7

3.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.63

0.43

1.6

1.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

1.63

0.43

4.0

3.4

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.58

0.42

1.2

1.5

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.41

0.0

1.3

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.41

0.0

1.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.41

0.0

1.1

—

(3026725) Estradiol (E2) [Moles/volume] in Serum or Plasma

0.00

0.39

0.0

1.4

—

0.28

—

(3045716) Anion gap in Serum or Plasma by calculation

0.00

0.39

0.0

1.9

—

10.84

—

(3024731) MCV [Entitic mean volume] in Red Blood Cells

136

1328

1.43

0.39

31.1

22.3

90.85

91.13

0.32

136

1310

(3035941) MCH [Entitic mass]

136

1329

1.42

0.39

31.1

22.2

30.20

30.37

0.50

136

1311

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

136

1329

1.42

0.39

31.6

22.6

40.01

40.78

0.88

136

1309

(3021387) Prolactin [Units/volume] in Serum or Plasma

1.40

0.38

1.2

1.5

258.20

357.67

mu/l

—

(4035726) Immunohistochemistry procedure

122

0.72

0.37

1.3

1.4

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.45

0.36

2.3

2.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.41

0.35

2.2

2.7

—

(3012516) Albumin [Mass/volume] in Urine

393

1.17

0.34

3.7

3.3

60.65

40.49

mg/l

0.32

255

(3020682) Albumin/Creatinine [Ratio] in Urine

404

1.17

0.32

4.4

3.9

9.28

7.54

mg/mmol

0.15

253

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

195

1.21

0.30

1.4

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

122

1182

1.21

0.30

19.6

13.8

83.07

81.33

ml/min/173m2

0.44

110

1096

(3000963) Hemoglobin [Mass/volume] in Blood

136

1330

1.41

0.30

31.5

22.4

134.32

136.41

g/l

0.83

136

1310

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

113

1.26

0.28

1.3

1.5

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.32

0.27

1.0

1.2

—

(3009343) pH of Capillary blood

1.18

0.25

7.1

3.5

7.43

7.42

—

(3008898) HLA-B27 [Presence]

1.36

0.24

1.0

1.1

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.26

0.22

1.2

1.7

—

(3018405) Lactate [Moles/volume] in Arterial blood

1.23

0.22

7.4

4.5

1.26

mmol/l

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.23

0.22

2.6

1.3

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

0.21

0.0

2.0

—

13.09

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.21

0.0

1.4

—

(3003129) Base excess in Capillary blood by calculation

0.00

0.21

0.0

1.7

—

2.98

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.3

—

(40765096) Chromosome analysis panel by Banding

0.00

0.21

0.0

1.4

—

(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

0.21

0.0

1.1

—

10.83

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

2.0

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

2.0

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

2.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.9

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

2.13

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.2

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.9

—

(21494434) Karyotype in Bone marrow

0.00

0.20

0.0

1.1

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.0

—

12.58

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

3.1

—

3.05

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

516

1.11

0.20

1.9

1.37

1.34

mmol/l

0.06

434

(3020891) Body temperature

1.18

0.19

7.0

3.4

37.15

36.98

°c

—

(3022313) Gas panel - Capillary blood

1.18

0.18

6.0

3.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

110

1.20

0.18

1.5

1.3

—

(3002256) Pathology report gross observation

158

1.16

0.17

1.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

114

1165

0.90

0.16

7.6

6.2

40.19

39.48

mmol/mol

0.29

109

1086

(3017732) Neutrophils [#/volume] in Blood

140

1.16

0.16

3.8

3.2

3.67

6.30

e9/l

0.88

123

(3003694) ABO and Rh group [Type] in Blood

334

1.10

0.15

1.1

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

325

0.90

0.15

4.4

22.11

21.45

0.09

151

(3019832) Treponema pallidum Ab [Presence] in Serum

1.16

0.09

1.3

1.8

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.09

0.09

2.0

1.7

—

5.92

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.07

0.09

1.2

1.6

35.60

39.40

nmol/l

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

120

1183

1.09

0.09

5.8

5.0

6.17

6.00

mmol/l

0.68

114

1089

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

126

1.12

0.09

12.6

6.5

—

(3000492) Spirometry study

131

1.08

0.03

1.4

1.6

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

246

0.97

0.00

3.4

3.0

0.72

0.80

ug/l

0.20

155

(3036185) Alkaline phosphatase.liver 2 [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

33.50

—

(3025941) Bacteria identified in Stool by Culture

0.93

0.00

1.8

1.2

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3035062) Alkaline phosphatase.liver 1 [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

83.33

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3027923) C peptide [Moles/volume] in Serum or Plasma

0.00

0.0

2.7

—

0.63

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

5.8

—

383.67

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.2

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

2.5

—

205.50

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

3.3

—

44.33

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

211.67

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.0

—

0.00

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.95

0.00

1.3

1.8

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.0

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

2.3

—

6.37

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

12.62

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

-0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.3

—

(3020013) Alkaline phosphatase.intestinal [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.7

—

2.71

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.3

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

216.30

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.0

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

80.20

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.2

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

4.6

—

1.29

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

-0.00

0.0

1.4

—

8.27

—

(40758292) HTLV I+II Ab panel - Serum

0.00

-0.00

0.0

1.8

—

(3010503) CD19 cells [#/volume] in Blood

0.00

-0.00

0.0

1.4

—

200.60

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.3

—

(3004446) Plasmodium sp identified in Blood by Light microscopy

0.00

-0.00

0.0

3.0

—

(3017704) Immunofixation for Urine

0.00

-0.00

0.0

2.4

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.3

—

(3024263) Appearance of Synovial fluid

0.00

-0.00

0.0

1.0

—

(3036048) Francisella tularensis Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

120

1.00

-0.00

1.4

1.6

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

9.2

—

7.80

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

63.91

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

-0.00

0.0

1.6

—

11.74

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.4

—

(3029536) Hepatitis C virus RNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3033306) Mononuclear cells/Leukocytes in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3017315) Amylase [Enzymatic activity/volume] in Urine

0.00

-0.00

0.0

1.3

—

183.14

—

(3038769) Chlamydophila pneumoniae IgG Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

24.10

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_FIBROBLASTNAS and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_FIBROBLASTNAS	1.513 [1.07, 2.14]	0.019
Birth year	0.992 [0.98, 1.0]	0.059

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 333 females with M13_FIBROBLASTNAS died.

Males

Parameter	HR [95% CI]	p-value
M13_FIBROBLASTNAS	1.146 [0.9, 1.45]	0.263
Birth year	0.993 [0.98, 1.0]	0.158

During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 384 males with M13_FIBROBLASTNAS died.

Mortality risk

Mortality risk for people of age

years, who have M13_FIBROBLASTNAS.

N-year risk	Females	Males
1	0.163%	0.247%
5	0.856%	1.611%
10	2.199%	3.758%
15	3.941%	7.482%
20	6.81%	12.945%

Relationships between endpoints

↥

Index endpoint: M13_FIBROBLASTNAS – Other fibroblastic disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other fibroblastic disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints