No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
487 |
4. Check minimum number of eventsNone |
487 |
5. Include endpointsNone |
487 |
6. Filter based on genotype QC (FinnGen only) |
429 |
Control definitions (FinnGen only)
- Control exclude
- L12_DERMATITISECZEMA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L28
- Name in latin
- Alia prurigo
Similar endpoints
↥List of similar endpoints to
Other prurigo
based on the number of shared cases.
Similar with more cases:
- Lichen simplex chronicus and prurigo
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2946 | 1765 | 1152 |
| Only index persons | 2609 | 1611 | 998 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 55.84 | 55.10 | 56.77 |
| Only index persons | 54.78 | 54.34 | 55.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 429 | 271 | 158 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.07 |
| Median age at first event (years) | 56.34 | 54.26 | 59.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 441
- Matched controls
- 4410
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L28.2
ICD-10 Finland
Other prurigo
4503599627370496.0
307.7
425
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
11.7
145.8
207
311
L29.9
ICD-10 Finland
Pruritus, unspecified
37.6
129.9
83
27
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
12.2
116.5
138
159
D07AC01
ATC
betamethasone; topical
8.2
104.3
306
953
D07AD01
ATC
clobetasol; topical
8.1
99.8
183
354
E0000UV, ,
ATC
8.1
97.2
322
1106
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
7.8
83.2
144
257
D07AC13
ATC
mometasone; topical
5.8
75.6
227
678
D09AB01
ATC
zinc bandage without supplements; topical
36.6
72.5
46
14
L20.0
ICD-10 Finland
Besnier prurigo
+∞
71.9
67
*
L28.1
ICD-10 Finland
Prurigo nodularis
757.5
67.9
65
*
D07AB02
ATC
hydrocortisone butyrate; topical
5.3
67.1
226
730
E000002, ,
ATC
7.2
59.0
101
174
E000001, ,
ATC
5.3
57.3
154
405
TQW80
NOMESCO Finland
Local dermatologic skincare
21.4
53.5
41
21
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
+∞
53.2
50
*
D07BA04
ATC
hydrocortisone and antiseptics; topical
7.2
52.7
88
147
D07AB08
ATC
desonide; topical
6.6
51.9
96
178
R06AE07
ATC
cetirizine; oral
4.4
50.3
278
1240
L29.8
ICD-10 Finland
Other pruritus
98.1
48.0
52
6
R06AX22
ATC
ebastine; oral
4.6
44.0
136
392
R06AX27
ATC
desloratadine; oral
3.7
38.5
182
701
D07BC01
ATC
betamethasone and antiseptics; topical
5.1
37.8
93
221
L28.0
ICD-10 Finland
Lichen simplex chronicus
399.4
37.6
37
*
XQ800
NOMESCO Finland
Prick test
6.9
35.7
59
96
D02AX
ATC
Other emollients and protectives
13.1
33.6
33
27
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
5.5
30.6
65
135
D07AA02
ATC
hydrocortisone; topical
4.2
30.3
94
266
D02AE01
ATC
carbamide; topical
6.0
29.3
56
105
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
68.8
28.3
32
5
S02
ICPC
Pruritus
7.6
27.6
41
59
R06AE09
ATC
levocetirizine; oral
3.7
26.9
102
331
L30.0
ICD-10 Finland
Nummular dermatitis
9.8
26.8
32
35
H02AB06
ATC
prednisolone; systemic
2.9
26.2
265
1505
E000006, ,
ATC
5.0
23.3
54
120
D07CC01
ATC
betamethasone and antibiotics; topical
3.6
23.2
89
289
E000007, ,
ATC
6.0
22.7
42
76
B86
ICD-10 Finland
Scabies
9.3
22.6
28
32
L30.3
ICD-10 Finland
Infective dermatitis
19.3
22.6
34
19
N05BB01
ATC
hydroxyzine; systemic
5.1
22.1
49
105
XQ802
NOMESCO Finland
Epicutan test
17.1
20.4
32
20
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.2
20.0
91
327
L20
ICD-10 Finland
Atopic dermatitis
+∞
19.9
19
*
A46
ICD-10 Finland
Erysipelas
3.1
19.5
97
367
S29
ICPC
Skin symptom/complaint other
2.8
19.4
126
552
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.3
19.4
41
84
D07XC01
ATC
betamethasone; topical
3.5
19.3
74
239
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
18.8
162
816
J01DB01
ATC
cefalexin; oral
3.9
18.4
396
3063
E000003, ,
ATC
6.1
17.8
32
56
XQ848
NOMESCO Finland
Dermatological photography
6.9
17.7
28
43
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
17.6
257
1628
R06AX13
ATC
loratadine; oral
2.9
16.8
92
366
N05CF01
ATC
zopiclone; oral
2.4
16.8
182
1008
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
7.6
16.7
24
33
L50.3
ICD-10 Finland
Dermatographic urticaria
16.2
16.4
26
17
L30.8
ICD-10 Finland
Other specified dermatitis
12.4
15.8
28
24
H02AB04
ATC
methylprednisolone; systemic
2.9
15.7
86
341
69820
ICD-8 Finland
Pruritus and related conditions, Prurigo
+∞
15.7
15
*
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.5
15.4
124
597
S18
ICPC
Laceration/cut
2.2
15.4
241
1541
J01FF01
ATC
clindamycin; systemic
2.4
15.3
146
759
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.2
14.9
185
1073
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.9
14.5
45
125
N03AX16
ATC
[U] pregabalin
2.4
14.4
129
649
L20.8
ICD-10 Finland
Other atopic dermatitis
+∞
13.6
13
*
L50.9
ICD-10 Finland
Urticaria, unspecified
4.8
13.5
31
68
J02AC01
ATC
fluconazole; systemic
2.1
13.3
191
1161
H02AB07
ATC
prednisone; oral
2.7
13.2
81
340
N02AX02
ATC
tramadol; systemic, rectal
2.1
12.7
212
1356
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
6.2
12.7
22
37
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
+∞
12.6
12
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
12.4
90
409
L04AX01
ATC
azathioprine; systemic
4.8
12.3
28
61
A02BC02
ATC
pantoprazole; systemic
2.2
12.2
320
2408
J01DA01
ATC
[U] cefalexin
2.1
12.2
289
2094
J01MA12
ATC
levofloxacin; systemic
2.4
11.9
98
471
Z71.8
ICD-10 Finland
Other specified counselling
2.1
11.9
171
1030
L04AA06
ATC
mycophenolic acid; systemic
11.5
11.7
21
19
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
11.5
213
1401
UJF30
NOMESCO Finland
Ileoscopy through colon
2.9
11.4
59
225
Z49.1
ICD-10 Finland
Extracorporeal dialysis
13.2
11.2
19
15
J45.9
ICD-10 Finland
Asthma, unspecified
2.3
11.1
103
520
J01MA02
ATC
ciprofloxacin; systemic
2.0
11.1
188
1195
R03AC02
ATC
salbutamol; inhalant
2.0
11.0
259
1840
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.5
11.0
76
336
N05BA04
ATC
oxazepam; oral
2.1
11.0
141
809
TK800
NOMESCO Finland
Hemodialysis
8.6
10.9
23
28
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
10.7
70
302
UKC02
NOMESCO Finland
Cystoscopy
2.4
10.6
82
382
R50.9
ICD-10 Finland
Fever, unspecified
2.4
10.6
82
382
127
Kela drug reimbursment
Transplant complication
12.5
10.4
18
15
S76
ICPC
Skin infection other
3.4
10.4
39
123
A11CC03
ATC
alfacalcidol; systemic
5.1
10.4
22
45
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
10.3
114
616
A10AB04
ATC
insulin lispro; parenteral
4.3
10.3
27
66
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
5.5
10.2
20
38
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.9
10.1
206
1383
A02BC05
ATC
esomeprazole; systemic
1.9
10.1
193
1269
J01FA06
ATC
roxithromycin; oral
1.9
9.9
186
1212
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
9.9
109
588
L04AD02
ATC
tacrolimus; systemic
20.6
9.9
14
7
M25.5
ICD-10 Finland
Pain in joint
2.0
9.9
157
968
L28
ICPC
Limited function/disability (L)
2.1
9.7
105
562
J46
ICD-10 Finland
Status asthmaticus
5.0
9.6
21
44
C03CA01
ATC
furosemide; systemic
1.9
9.6
157
976
SPAT1255
SPAT
Intravenous administration of medicine
3.1
9.5
40
136
L73.8
ICD-10 Finland
Other specified follicular disorders
12.7
9.4
16
13
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.5
9.4
33
100
A08
ICPC
Swelling
3.1
9.3
41
143
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.4
9.2
66
297
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
11.8
9.1
16
14
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
37.5
9.1
11
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.4
9.1
71
332
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
8.9
75
362
R06.0
ICD-10 Finland
Dyspnoea
1.9
8.8
135
817
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
8.8
93
492
C08CA13
ATC
lercanidipine; oral
2.2
8.7
81
407
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
8.7
94
501
M79.6
ICD-10 Finland
Pain in limb
1.8
8.7
206
1430
D05BB02
ATC
acitretin; oral
7.6
8.5
19
26
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.5
8.5
58
254
Z3231
NOMESCO Finland
Registered nurse
1.9
8.5
132
801
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
8.5
89
469
R07.0
ICD-10 Finland
Pain in throat
3.1
8.4
36
123
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
8.4
123
730
R03DC03
ATC
montelukast; oral
2.2
8.4
84
434
R05
ICD-10 Finland
Cough
2.0
8.4
109
621
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
+∞
8.4
8
*
M54.5
ICD-10 Finland
Low back pain
1.8
8.3
168
1106
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.9
8.3
143
895
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.1
8.3
36
124
L04AX03
ATC
methotrexate; systemic
2.5
8.3
55
238
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
8.2
86
452
L40.0
ICD-10 Finland
Psoriasis vulgaris
4.2
8.2
22
55
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
8.1
61
279
N03AX12
ATC
[U] gabapentin; oral
2.1
8.1
81
418
N06AA09
ATC
amitriptyline; systemic
2.6
8.1
51
215
S01
ICPC
Pain/tenderness of skin
3.5
8.1
28
84
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.8
8.1
41
155
J01AA02
ATC
doxycycline; systemic
2.0
8.0
342
2811
J01DA09
ATC
[U] cefadroxil
1.9
8.0
119
709
D11
ICPC
Diarrhoea
2.3
8.0
64
302
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.8
8.0
42
162
N06AX11
ATC
mirtazapine; oral
1.8
7.9
165
1094
WX002
NOMESCO Finland
Sedation and analgesia
2.0
7.8
95
527
SPAT1263
SPAT
Sampling
1.8
7.8
192
1335
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
4.5
7.8
19
44
Z94.0
ICD-10 Finland
Kidney transplant status
15.4
7.8
12
8
V03AE03
ATC
lanthanum carbonate; oral
45.8
7.7
9
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
7.7
57
259
M10.0
ICD-10 Finland
Idiopathic gout
4.1
7.7
21
53
L03
ICPC
Low back symptom/complaint
1.8
7.7
140
890
B05DB
ATC
Hypertonic solutions
25.5
7.6
10
*
J01CF05
ATC
flucloxacillin; systemic
2.7
7.6
41
160
N06AA12
ATC
doxepin; systemic
2.9
7.6
36
131
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
7.5
168
1133
J01FA09
ATC
clarithromycin; systemic
1.8
7.5
141
904
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.3
7.5
63
303
R03BA05
ATC
fluticasone; inhalant
2.0
7.4
88
484
C01CA24
ATC
epinephrine; parenteral
3.0
7.4
33
116
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
7.4
183
1271
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
7.4
111
663
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.9
7.3
34
122
L01
ICPC
Neck symptom/complaint
2.1
7.3
82
441
R01AD09
ATC
mometasone; nasal
1.7
7.3
200
1427
R03BA02
ATC
budesonide; inhalant
2.0
7.3
88
487
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.8
7.3
37
140
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
16.1
7.3
11
7
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
7.2
77
407
Z49.2
ICD-10 Finland
Other dialysis
20.4
7.2
10
5
H04.10
ICD-10 Finland
Dry eye syndrome
2.3
7.2
60
288
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.9
7.1
119
733
Z49.0
ICD-10 Finland
Preparatory care for dialysis
12.3
7.1
12
10
A02BC01
ATC
omeprazole; systemic
1.8
7.1
129
817
R42
ICD-10 Finland
Dizziness and giddiness
1.9
7.1
117
719
S87
ICPC
Dermatitis/atopic eczema
7.2
7.1
16
23
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.8
7.0
126
793
N02BF01
ATC
gabapentin; oral
2.3
7.0
56
263
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.4
7.0
51
230
ZXE20
NOMESCO Finland
More than three and less than five hours
2.1
7.0
68
347
L17
ICPC
Foot/toe symptom/complaint
1.8
7.0
144
946
A06AD11
ATC
lactulose; oral
2.1
7.0
76
405
L04AD01
ATC
ciclosporin; systemic
7.7
7.0
15
20
A01AB09
ATC
miconazole; local oral
2.4
6.9
49
218
R96
ICPC
Asthma
2.3
6.9
53
245
J01FA15
ATC
telithromycin; oral
2.4
6.8
48
213
S97
ICPC
Chronic ulcer skin
2.5
6.8
42
175
D64.9
ICD-10 Finland
Anaemia, unspecified
2.2
6.8
57
273
R53
ICD-10 Finland
Malaise and fatigue
1.8
6.8
125
792
R13
ICD-10 Finland
Dysphagia
2.7
6.8
38
151
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
6.8
96
560
S21
ICPC
Skin texture symptom/complaint
2.1
6.8
74
394
L98.1
ICD-10 Finland
Factitial dermatitis
40.7
6.8
8
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
17.0
6.8
10
6
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
2.8
6.7
34
128
A02BC03
ATC
lansoprazole; oral
1.8
6.7
136
888
J01FA10
ATC
azithromycin; systemic
1.7
6.7
247
1898
C07AB02
ATC
metoprolol; systemic
1.9
6.6
96
564
R02
ICPC
Shortness of breath/dyspnoea
2.1
6.6
69
361
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.1
6.6
27
90
137
Kela drug reimbursment
Uraemia requiring dialysis
12.5
6.6
11
9
L29
ICD-10 Finland
Pruritus
8.9
6.6
13
15
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.3
6.5
25
80
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
6.5
49
224
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
6.5
76
414
R01AD58
ATC
fluticasone, combinations; nasal
1.8
6.5
105
639
D11AH01
ATC
tacrolimus; topical
70.8
6.4
7
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
14.6
6.4
10
7
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
14.6
6.4
10
7
B05DA
ATC
Isotonic solutions
14.6
6.4
10
7
L57.0
ICD-10 Finland
Actinic keratosis
2.2
6.4
58
287
SBA00
NOMESCO Finland
Microbiological examinations
4.2
6.4
17
42
WX892
NOMESCO Finland
Monitored bed care
2.5
6.4
39
162
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.9
6.4
29
103
L43.8
ICD-10 Finland
Other lichen planus
6.7
6.4
15
23
C03DA01
ATC
spironolactone; oral
2.1
6.4
61
309
AA1AD
NOMESCO Finland
CT of head and brain
1.7
6.4
140
933
R4110
NOMESCO Finland
Physiotherapy
1.8
6.3
128
832
U07
ICPC
Urine symptom/complaint other
2.4
6.3
44
195
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
2.6
6.3
37
151
TK824
NOMESCO Finland
Replacement of peritoneal dialysis catheter extension tube
+∞
6.3
6
*
J04BA02
ATC
dapsone; oral
27.1
6.2
8
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
3.6
6.2
20
57
A02BA03
ATC
famotidine; systemic
3.4
6.2
22
67
C08CA01
ATC
amlodipine; oral
1.7
6.2
176
1254
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
6.2
89
521
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.5
6.2
40
171
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
6.2
122
787
M04AA01
ATC
allopurinol; systemic
2.1
6.2
61
313
UJF32
NOMESCO Finland
Coloscopy
1.8
6.1
118
755
A02BA02
ATC
ranitidine; systemic
1.9
6.1
91
539
WW200
NOMESCO Finland
Immunization
5.3
6.1
17
33
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
5.3
6.1
17
33
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
6.1
90
532
L50.8
ICD-10 Finland
Other urticaria
6.2
6.0
15
25
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.2
6.0
55
273
C08CA05
ATC
nifedipine; systemic
2.7
6.0
33
130
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
277
1679
2.75
23.02
7.4
4.6
35.47
35.60
g/l
0.14
264
1589
189
1008
2.53
19.57
2.8
2.2
2.87
2.93
mg/l
0.11
168
868
173
886
2.57
19.51
1.5
1.3
1.04
1.48
u/ml
0.56
41
240
130
617
2.57
16.81
4.0
2.4
2.34
2.30
g/l
0.29
121
566
135
658
2.52
16.46
4.0
2.4
12.58
12.86
umol/l
0.18
129
608
98
419
2.72
15.52
3.8
4.0
227.81
265.40
u/l
1.09
93
393
120
569
2.52
15.39
4.3
2.4
22.01
22.30
%
0.08
114
531
107
483
2.60
15.18
14.3
5.0
1.06
1.03
mmol/l
0.50
102
441
142
745
2.34
14.43
4.2
4.1
305.79
467.66
ng/l
0.40
115
601
148
798
2.29
14.04
1.8
1.4
2.61
2.39
g/l
0.57
101
475
256
1730
2.14
13.57
3.2
2.5
79.25
78.18
nmol/l
0.20
236
1543
264
1814
2.13
13.29
4.7
3.0
123.89
122.14
ug/l
0.04
255
1681
286
2032
2.16
13.12
8.9
6.3
10.82
11.20
umol/l
0.38
275
1941
278
1961
2.13
12.90
14.1
6.9
1.21
1.21
mmol/l
0.16
255
1682
307
2268
2.16
12.37
8.0
4.5
7.10
6.67
mmol/l
2.40
296
2148
123
646
2.25
12.19
2.4
1.9
—
—
—
0
0
296
2176
2.10
11.81
14.0
9.1
4.14
4.08
e9/l
0.15
271
1886
190
1207
2.01
11.26
3.7
2.4
54.11
61.40
u/l
0.92
180
1121
88
416
2.39
11.05
2.5
2.5
5.22
8.45
umol/l
2.18
75
363
155
923
2.05
10.94
4.4
2.6
355.44
341.56
umol/l
0.78
136
814
182
1154
1.98
10.72
2.0
1.7
21.37
20.43
nmol/l
0.39
161
961
351
2799
2.24
10.72
7.3
4.2
15.84
12.10
mm/h
3.87
345
2610
196
1290
1.93
10.23
4.3
3.4
6.95
7.49
mmol/l
1.04
177
1078
69
302
2.52
10.20
6.0
3.6
143.22
80.17
ng/l
3.18
62
268
66
285
2.55
10.02
2.0
1.6
—
—
—
0
0
249
1781
1.91
10.02
12.1
5.9
1.21
1.21
mmol/l
0.04
231
1633
355
2881
2.19
9.79
13.7
7.9
79.57
79.07
u/l
0.09
348
2718
20
40
5.19
9.66
1.4
2.1
11.62
7.13
umol/l
0.66
15
27
37
119
3.30
9.58
1.3
3.5
0.07
0.84
g/l
1.86
32
102
189
1254
1.89
9.42
5.1
4.1
13.04
7.57
mg/mmol
0.63
133
769
183
1204
1.89
9.34
2.8
2.1
260.65
237.25
u/l
0.09
172
1147
198
1339
1.87
9.25
3.8
3.5
2.35
2.36
mmol/l
0.34
184
1215
65
292
2.44
9.05
3.4
3.4
306.63
216.48
ng/l
0.49
60
267
183
1214
1.87
9.03
3.6
3.2
3688.86
1380.87
ng/l
1.14
166
1043
26
69
3.94
8.92
16.3
5.4
245.20
508.11
iu/ml
—
5
9
247
1812
1.83
8.69
23.8
13.6
1.33
1.24
inr
1.34
208
1512
92
489
2.11
8.57
2.1
1.9
—
—
—
0
0
351
2891
2.05
8.48
5.4
4.3
14.85
14.88
pmol/l
0.07
334
2623
23
58
4.13
8.44
2.1
1.3
177.20
152.72
au/ml
—
5
20
76
382
2.20
8.14
2.1
1.9
322.04
393.76
nmol/l
2.77
70
355
236
1733
1.78
8.04
2.6
2.1
93.06
97.04
pmol/l
0.75
139
911
392
3420
2.32
7.35
6.8
5.4
1.83
1.93
mu/l
1.17
384
3150
85
463
2.04
7.35
2.0
1.9
—
—
—
0
0
7
0
+∞
7.31
6.0
0.0
—
—
—
0
0
41
164
2.65
7.24
1.5
1.8
1.55
1.47
g/l
0.26
34
147
204
1468
1.73
7.21
5.7
3.8
153.22
107.88
e6/l
0.25
147
1024
136
875
1.80
7.08
1.9
1.6
1.70
1.29
mg/l
0.27
113
692
264
2058
1.70
6.79
5.4
3.9
0.00
7.70
estimate
0.80
64
455
278
2199
1.71
6.76
3.2
3.0
—
—
—
0
0
261
2037
1.69
6.61
5.3
3.9
0.00
0.00
estimate
0.50
63
440
17
41
4.27
6.61
1.2
1.2
—
—
—
0
0
105
641
1.84
6.42
1.4
1.3
3.10
12.39
u/ml
3.02
38
247
123
791
1.77
6.32
2.7
2.8
2.45
2.46
mmol/l
0.34
110
717
29
104
2.91
6.28
1.4
1.3
264.35
325.38
ug/g
0.81
20
61
66
348
2.05
6.20
3.8
2.1
0.21
0.21
g/l
0.19
61
328
135
898
1.73
6.13
3.8
2.6
6.61
6.52
e6/l
0.02
124
816
31
117
2.77
6.13
1.8
1.5
0.32
0.05
iu/ml
—
6
26
180
1295
1.66
6.09
4.6
3.2
283.71
97.07
e6/l
0.38
142
978
32
124
2.70
6.02
2.1
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
27
96
2.93
5.94
3.5
2.4
0.32
0.31
iu/ml
0.07
13
54
262
2080
1.64
5.92
5.4
3.9
0.05
0.73
estimate
0.47
60
419
33
132
2.62
5.85
2.5
1.8
—
—
—
0
0
136
917
1.70
5.84
2.9
2.3
—
—
—
0
0
111
708
1.76
5.81
1.4
1.3
17.94
36.56
iu/ml
3.15
24
228
21
65
3.34
5.80
1.5
1.2
208.73
248.55
u/ml
0.22
15
33
123
811
1.72
5.72
2.0
1.8
76147269.94
8457414.15
pmol/l
0.42
109
674
107
685
1.74
5.50
2.0
1.7
1141.46
1214.13
nmol/l
0.34
88
505
19
57
3.44
5.50
1.5
1.3
—
—
—
0
0
31
125
2.59
5.42
1.7
1.5
—
—
—
0
0
21
69
3.15
5.29
1.7
1.4
—
—
—
0
0
64
356
1.93
5.16
3.4
2.1
34.35
32.28
u/l
0.11
57
292
154
1105
1.60
5.06
4.5
3.1
0.34
0.58
e6/l
1.15
121
795
24
89
2.79
4.92
1.2
1.5
—
—
—
0
0
26
101
2.67
4.90
2.4
1.6
5899.11
18376.19
e6/l
1.16
18
74
52
274
2.02
4.89
3.2
3.1
71.00
62.57
ml/min/173m2
0.86
27
110
22
80
2.84
4.68
2.3
1.5
—
—
—
0
0
45
229
2.07
4.65
1.7
1.7
—
—
—
0
0
22
81
2.81
4.58
1.6
1.5
—
—
—
0
0
102
675
1.66
4.58
3.4
2.8
1.01
1.14
e6/l
0.18
53
337
401
3667
2.03
4.51
30.7
15.4
22.80
23.62
mg/l
0.22
356
3021
9
12
7.63
4.37
1.8
1.3
8.22
8.10
ug/l
—
9
12
20
72
2.86
4.34
1.5
1.2
—
—
—
0
0
20
72
2.86
4.34
1.5
1.2
—
—
—
0
0
25
102
2.54
4.29
1.7
2.6
10.03
11.43
mg/l
0.39
25
94
8
9
9.03
4.29
1.6
1.0
—
—
—
0
0
95
632
1.64
4.15
3.7
2.9
2.34
2.44
e6/l
0.05
44
294
29
130
2.32
4.09
3.4
3.2
—
—
—
0
0
26
112
2.40
4.00
2.2
1.3
—
—
—
0
0
20
76
2.71
3.95
1.4
1.5
—
—
—
0
0
18
66
2.80
3.80
2.1
1.5
—
—
—
0
0
23
97
2.45
3.71
1.3
1.2
—
—
—
0
0
41
220
1.95
3.69
5.0
3.3
2.02
2.02
mmol/l
0.00
36
159
8
12
6.77
3.69
2.0
1.9
0.58
0.61
mmol/l
—
8
12
40
215
1.95
3.58
13.1
7.9
15.10
15.91
%
1.11
40
206
287
2470
1.46
3.52
5.1
3.2
49.30
46.20
u/l
0.27
276
2337
24
107
2.31
3.45
2.3
1.5
—
—
—
0
0
14
47
3.04
3.44
2.0
1.2
—
—
—
0
0
18
70
2.64
3.42
9.8
3.3
15.35
9.80
pmol/l
0.68
18
70
63
402
1.66
3.22
6.0
3.3
—
—
—
0
0
383
3527
1.65
3.20
6.6
5.1
6.04
5.95
mmol/l
0.62
366
3223
16
61
2.68
3.17
1.4
1.6
—
—
—
0
0
21
93
2.32
3.08
2.7
1.6
—
—
—
0
0
16
62
2.64
3.08
1.2
1.3
—
—
—
0
0
216
1793
1.40
3.06
3.3
2.7
—
—
estimate
—
0
0
23
107
2.21
3.02
2.2
1.3
—
—
—
0
0
43
251
1.79
3.02
1.1
1.3
172.44
155.11
u/ml
0.10
16
97
5
5
10.09
2.98
1.0
1.2
1.11
1.13
mmol/l
—
5
5
5
5
10.09
2.98
1.0
1.4
—
—
—
0
0
20
89
2.31
2.91
3.0
2.2
117.79
129.05
g/l
1.39
14
73
7
13
5.45
2.88
2.1
1.7
—
—
—
0
0
7
13
5.45
2.88
2.1
1.7
—
—
—
0
0
7
13
5.45
2.88
2.1
1.7
—
—
—
0
0
5
6
8.41
2.75
1.0
1.0
1.09
0.39
u/ml
—
5
6
34
191
1.85
2.71
5.3
4.3
1.65
1.56
%
0.26
34
179
39
229
1.77
2.70
13.5
7.8
24.96
24.58
mmol/l
0.29
39
224
375
3469
1.54
2.69
8.7
6.4
40.92
39.39
mmol/mol
2.08
363
3258
88
633
1.49
2.69
1.6
1.6
—
—
—
0
0
22
106
2.13
2.67
1.9
1.5
—
—
—
0
0
7
15
4.72
2.60
4.6
6.5
—
—
—
0
0
158
1271
1.38
2.60
5.5
3.0
27.20
32.40
u/l
2.63
145
1200
21
101
2.13
2.57
1.9
1.8
1.88
5.72
iu/l
1.75
15
37
8
21
3.86
2.47
1.5
1.3
—
—
—
0
0
181
1502
1.35
2.41
5.0
3.9
58.95
94.54
ng/l
0.36
133
1114
24
125
1.97
2.40
1.5
1.2
—
—
—
0
0
8
22
3.68
2.37
1.5
1.3
—
—
—
0
0
8
22
3.68
2.37
2.3
2.1
—
—
—
0
0
377
3514
1.50
2.37
28.6
15.4
76.30
79.84
ml/min/173m2
1.96
359
3270
64
446
1.51
2.28
10.3
6.6
1.41
1.09
mmol/l
0.27
56
371
8
23
3.52
2.28
1.5
1.4
—
—
—
0
0
58
396
1.54
2.27
3.2
2.1
—
—
—
0
0
383
3591
1.51
2.23
6.3
5.1
4.51
4.63
mmol/l
1.50
365
3353
389
3661
1.53
2.20
6.9
5.8
2.60
2.69
mmol/l
1.14
371
3409
8
24
3.38
2.19
1.4
1.3
—
—
—
0
0
8
24
3.38
2.19
1.4
1.3
—
—
—
0
0
49
325
1.57
2.18
9.2
4.0
1.21
1.23
mmol/l
1.35
42
280
7
19
3.73
2.16
2.1
1.6
—
—
—
0
0
7
19
3.73
2.16
1.3
1.7
746.14
365.93
e6/l
—
7
14
7
19
3.73
2.16
1.4
1.2
—
—
—
0
0
7
19
3.73
2.16
2.1
1.6
—
—
—
0
0
7
19
3.73
2.16
1.4
1.2
—
—
—
0
0
7
19
3.73
2.16
2.1
1.6
—
—
—
0
0
7
19
3.73
2.16
2.1
1.6
—
—
—
0
0
13
55
2.41
2.14
1.5
2.2
32.77
32.36
pg
0.11
13
55
53
362
1.53
2.08
3.2
2.0
—
—
—
0
0
43
280
1.59
2.07
1.4
1.4
—
—
—
0
0
366
3419
1.41
2.01
5.3
4.2
1.32
1.27
mmol/l
0.83
346
3153
20
105
1.95
1.99
2.5
2.1
243.90
186.31
%
1.06
20
100
23
127
1.86
1.98
1.7
1.2
—
—
—
0
0
380
3578
1.45
1.95
6.1
5.0
1.45
1.49
mmol/l
1.13
362
3327
20
106
1.93
1.94
3.3
3.0
1.62
2.02
index
—
8
57
413
3961
1.67
1.90
44.1
23.7
4.34
4.46
e12/l
4.51
407
3883
7
22
3.22
1.88
1.9
1.3
88.29
76.59
umol/l
—
7
22
11
46
2.43
1.86
3.0
1.9
89.21
90.23
%
0.29
11
46
39
255
1.58
1.86
6.6
2.9
121.97
129.49
g/l
1.13
39
247
21
115
1.87
1.86
2.7
2.3
9162.34
3968.84
u/l
—
5
46
6
17
3.56
1.84
3.3
1.8
41.67
54.52
ug/l
—
6
17
403
3848
1.55
1.83
21.1
11.7
24.76
25.30
u/l
0.35
397
3747
5
12
4.20
1.83
1.2
2.8
34.04
41.76
g/l
—
5
12
9
35
2.60
1.81
1.1
1.2
—
—
—
0
0
33
211
1.61
1.74
1.8
1.3
—
—
—
0
0
17
89
1.95
1.72
2.4
2.6
44.50
84.95
ug/min
0.50
11
50
20
112
1.82
1.67
1.5
4.8
1.43
2.61
ratio
1.08
12
68
13
63
2.10
1.61
1.2
1.1
0.38
2.05
u/ml
—
8
31
11
50
2.23
1.58
1.8
1.4
—
—
—
0
0
8
33
2.45
1.54
1.4
1.3
—
—
—
0
0
16
280
0.56
1.52
1.3
1.7
3.06
3.53
mmol/l
—
8
214
9
38
2.40
1.46
2.7
1.6
—
—
—
0
0
7
28
2.52
1.45
1.0
1.0
—
—
—
0
0
16
88
1.85
1.43
2.3
1.4
—
—
—
0
0
21
126
1.70
1.42
1.4
1.6
11.94
13.93
u/ml
—
5
21
9
40
2.28
1.41
1.6
1.2
—
—
—
0
0
9
42
2.17
1.34
2.7
1.6
—
—
—
0
0
8
34
2.38
1.29
1.6
1.5
—
—
—
0
0
5
18
2.80
1.29
1.0
1.2
—
—
—
0
0
5
18
2.80
1.29
1.0
1.2
—
—
—
0
0
73
579
1.31
1.28
1.4
1.5
—
—
—
0
0
26
171
1.55
1.26
5.2
1.8
—
—
—
0
0
50
375
1.38
1.26
13.1
7.0
119.24
122.16
g/l
0.58
50
367
10
49
2.06
1.23
1.0
1.1
—
—
—
0
0
177
1567
1.22
1.21
2.3
1.9
1.39
1.29
mmol/l
0.77
164
1292
10
51
1.98
1.12
1.9
1.3
—
—
—
0
0
7
31
2.28
1.11
1.6
1.7
—
—
—
0
0
7
32
2.21
1.08
2.6
1.6
—
—
—
0
0
7
32
2.21
1.08
2.6
1.6
—
—
—
0
0
7
32
2.21
1.08
2.6
1.6
—
—
—
0
0
10
52
1.94
1.07
1.9
1.3
—
—
—
0
0
10
52
1.94
1.07
1.9
1.3
—
—
—
0
0
10
52
1.94
1.07
1.9
1.3
—
—
—
0
0
10
52
1.94
1.07
1.9
1.3
—
—
—
0
0
10
52
1.94
1.07
1.9
1.3
—
—
—
0
0
11
60
1.85
1.03
1.0
1.4
0.45
0.61
nmol/l
1.81
11
55
7
34
2.08
1.03
1.0
1.1
86.00
104.56
pmol/l
—
7
34
27
375
0.70
0.99
1.4
1.9
3.23
3.45
ratio
0.27
19
306
9
49
1.85
0.99
1.1
1.1
—
1.26
—
0
14
10
54
1.87
0.97
1.4
1.4
—
—
—
0
0
6
118
0.50
0.95
1.2
1.1
1.40
1.59
g/l
—
6
118
130
1142
1.20
0.94
5.3
3.4
0.00
0.08
estimate
0.60
51
351
6
28
2.16
0.92
1.5
1.1
—
—
—
0
0
53
424
1.28
0.90
3.4
4.5
5.10
41.18
ug/l
1.20
40
359
6
31
1.95
0.84
1.0
1.1
—
—
—
0
0
6
32
1.89
0.82
1.0
1.1
—
—
—
0
0
6
32
1.89
0.82
1.7
3.0
1200.50
828.47
mg
—
6
32
26
190
1.39
0.81
1.5
1.3
—
—
—
0
0
6
33
1.83
0.79
1.0
1.1
—
—
—
0
0
6
33
1.83
0.79
1.0
1.1
—
—
—
0
0
17
115
1.50
0.78
1.1
1.1
—
—
—
0
0
56
461
1.25
0.77
5.2
5.0
32.07
32.07
%
0.00
42
298
17
116
1.48
0.75
1.1
1.1
—
—
—
0
0
26
193
1.37
0.75
1.0
1.0
—
—
—
0
0
7
38
1.86
0.74
5.7
4.0
—
—
—
0
0
7
40
1.76
0.71
1.0
1.0
—
—
—
0
0
7
43
1.64
0.67
2.9
2.2
—
—
—
0
0
21
154
1.38
0.66
1.3
1.4
0.42
0.34
mg/l
0.21
13
65
28
217
1.31
0.63
5.1
1.9
—
—
—
0
0
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
6
36
1.68
0.57
1.0
1.1
—
—
—
0
0
11
74
1.50
0.54
1.3
1.8
3.98
4.84
mmol/24h
0.49
11
64
6
40
1.51
0.52
1.0
1.1
—
—
—
0
0
112
1024
1.13
0.48
4.9
5.5
3.18
3.07
ug/l
0.04
97
908
168
1573
1.11
0.47
5.3
3.8
0.04
0.02
estimate
0.13
53
362
16
120
1.35
0.47
1.2
1.3
198.42
272.15
miu/ml
—
5
46
23
183
1.27
0.46
4.1
3.3
25.70
25.22
mmol/l
0.25
23
175
31
257
1.22
0.44
2.6
2.5
11.31
13.08
nmol/l
0.59
26
234
5
31
1.62
0.43
1.2
1.1
—
—
—
0
0
5
31
1.62
0.43
1.2
1.1
—
—
—
0
0
5
31
1.62
0.43
1.4
1.2
—
—
—
0
0
126
1169
1.11
0.42
5.8
3.9
0.00
0.01
estimate
0.99
58
411
13
96
1.36
0.42
1.5
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
106.33
—
0
9
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
99
909
1.11
0.40
4.9
3.9
1.01
1.02
kg/l
3.83
76
597
14
108
1.31
0.35
1.6
1.5
—
—
—
0
0
6
45
1.34
0.34
1.2
1.2
—
—
—
0
0
46
409
1.14
0.32
7.6
6.5
—
—
—
0
0
7
57
1.23
0.29
1.1
1.5
72.93
51.56
ug/l
—
7
57
13
103
1.27
0.28
1.6
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
96.25
—
0
8
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
14
0.00
0.20
0.0
1.1
—
123.29
—
0
14
9
112
0.80
0.20
2.0
1.7
—
—
—
0
0
12
99
1.22
0.20
1.4
1.3
—
—
—
0
0
6
50
1.20
0.20
1.5
1.1
—
—
—
0
0
10
121
0.82
0.18
1.6
1.1
0.81
0.91
g/l
—
10
121
8
69
1.16
0.16
1.4
1.7
—
—
—
0
0
84
812
1.04
0.10
4.1
4.6
21.46
22.05
%
0.11
33
394
5
64
0.78
0.08
2.0
1.5
—
—
—
0
0
7
68
1.03
0.08
2.0
1.7
—
—
—
0
0
59
602
0.98
0.03
2.9
3.3
0.60
0.86
ug/l
2.33
40
385
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
1.32
—
0
6
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_PRURIGONAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PRURIGONAS | 1.386 [1.18, 1.63] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.214 |
During the follow-up period (1.1.1998 — 31.12.2019), 337 out of 1532 females with L12_PRURIGONAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PRURIGONAS | 1.635 [1.33, 2.01] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 342 out of 1002 males with L12_PRURIGONAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_PRURIGONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.094% | 0.339% |
| 5 | 0.64% | 1.753% |
| 10 | 1.935% | 4.381% |
| 15 | 3.65% | 8.135% |
| 20 | 6.816% | 13.54% |
Relationships between endpoints
↥Index endpoint: L12_PRURIGONAS – Other prurigo
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data