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Other and unspecified pemphigoid

DOID Endpoint Browser PheWeb

L12_PEMPHIGOID_NAS

bullous pemphigoid: Bullous pemphigoid (BP) is the most common form of autoimmune bullous dermatosis.

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L12.8, L12.9, L12.9+H13.3
  • Hospital discharge: ICD-9 — 6945
  • Hospital discharge: ICD-8 — 69402
  • Cause of death: ICD-10 — L12.8, L12.9, L12.9+H13.3
  • Cause of death: ICD-9 — 6945
  • Cause of death: ICD-8 — 69402
  • KELA reimbursements: KELA codes — ANY
  • KELA reimbursements: ICD-10 — L12

3 out of 7 registries used, show all original rules.

370

4. Check minimum number of events

None

370

5. Include endpoints

None

370

6. Filter based on genotype QC (FinnGen only)

331

Control definitions (FinnGen only)

Control exclude
L12_BULLOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2871 1684 1154
Only index persons 2032 1255 777
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.03
Only index persons 0.04 0.05 0.03
Median age at first event (years)
Whole population 75.93 76.22 75.54
Only index persons 75.51 76.02 74.67

-FinnGen-

Key figures

All Female Male
Number of individuals 331 179 152
Unadjusted period prevalence (%) 0.07 0.06 0.07
Median age at first event (years) 73.25 71.45 75.37

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
339
Matched controls
3390
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L12.9
ICD-10 Finland
Pemphigoid, unspecified
1820.5
249.7
212
*
L12.0
ICD-10 Finland
Bullous pemphigoid
3670.2
205.0
177
*
L12.8
ICD-10 Finland
Other pemphigoid
+∞
133.4
119
*
D07AD01
ATC
clobetasol; topical
10.9
111.4
185
337
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
11.5
107.6
149
216
L04AX01
ATC
azathioprine; systemic
17.0
81.0
73
54
D07AC01
ATC
betamethasone; topical
6.6
62.1
237
883
135
Kela drug reimbursment
Pemphigus
+∞
53.6
50
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.6
53.3
149
414
TQW80
NOMESCO Finland
Local dermatologic skincare
14.5
52.4
50
40
H02AB06
ATC
prednisolone; systemic
6.5
49.5
271
1286
J04BA02
ATC
dapsone; oral
181.2
46.1
47
*
E0000UV, ,
ATC
4.6
40.9
225
1015
L04AX03
ATC
methotrexate; systemic
6.1
40.4
83
171
XQ848
NOMESCO Finland
Dermatological photography
10.8
38.5
44
46
L12.1
ICD-10 Finland
Cicatricial pemphigoid
+∞
32.8
31
*
D07AC13
ATC
mometasone; topical
3.5
27.5
154
657
L13.9
ICD-10 Finland
Bullous disorder, unspecified
140.3
25.0
26
*
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.0
24.1
84
260
EKA10
NOMESCO Finland
iopsy of buccal mucosa
9.0
23.5
30
36
K13.78
ICD-10 Finland
Other change in the oral mucosa
8.9
21.7
28
34
ECA20
NOMESCO Finland
Biopsy of gingiva
36.5
21.5
27
8
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
7.3
20.8
32
48
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
8.3
19.8
27
35
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
19.7
189
1043
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
17.4
79
286
E000001, ,
ATC
3.0
17.1
95
387
H13.3*L12.9
ICD-10 Finland
Ocular pemphigoid
+∞
16.8
16
*
S99
ICPC
Skin disease other
6.7
16.5
27
43
L12
ICD-10 Finland
Pemphigoid
167.4
15.6
16
*
D07BC01
ATC
betamethasone and antiseptics; topical
3.4
15.6
66
228
D07AB08
ATC
desonide; topical
3.4
15.4
65
224
L29.9
ICD-10 Finland
Pruritus, unspecified
6.7
15.2
25
40
D07AB02
ATC
hydrocortisone butyrate; topical
2.5
14.5
133
692
SBA00
NOMESCO Finland
Microbiological examinations
10.0
13.2
26
28
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.5
12.6
46
144
S29
ICPC
Skin symptom/complaint other
2.4
11.3
94
460
A02BC02
ATC
pantoprazole; systemic
2.4
10.3
260
1973
D09AB01
ATC
zinc bandage without supplements; topical
8.0
10.1
22
29
A46
ICD-10 Finland
Erysipelas
2.4
9.9
78
370
A10AB05
ATC
insulin aspart; parenteral
3.0
9.8
47
173
R06AX27
ATC
desloratadine; oral
2.3
9.6
91
468
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.2
9.1
102
560
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.1
8.9
125
747
J01DB01
ATC
cefalexin; oral
2.5
8.9
287
2328
L04AA06
ATC
mycophenolic acid; systemic
9.4
8.6
17
19
L10.9
ICD-10 Finland
Pemphigus, unspecified
+∞
8.4
8
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
8.4
73
361
J01FF01
ATC
clindamycin; systemic
2.1
8.3
107
617
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.0
8.2
109
637
XQ802
NOMESCO Finland
Epicutan test
4.5
8.1
20
47
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.8
8.0
25
70
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
7.9
104
603
K12.10
ICD-10 Finland
Stomatitis NOS
18.9
7.6
11
6
L43.8
ICD-10 Finland
Other lichen planus
7.4
7.6
17
24
A28
ICPC
Limited function/disability NOS
2.0
7.5
103
606
L28.1
ICD-10 Finland
Prurigo nodularis
13.8
7.4
12
9
L29.8
ICD-10 Finland
Other pruritus
11.2
7.4
13
12
SPAT1262
SPAT
Handing over of treatment supplies
2.1
7.4
80
431
B86
ICD-10 Finland
Scabies
8.2
7.2
15
19
A10AE04
ATC
insulin glargine; parenteral
2.4
7.1
51
230
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.0
7.1
96
559
H02AB07
ATC
prednisone; oral
2.2
7.1
63
313
SPAT1167
SPAT
Insertion of urinary catheter
3.6
7.0
23
67
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
14.2
6.9
11
8
L30.0
ICD-10 Finland
Nummular dermatitis
3.8
6.9
21
58
H04.10
ICD-10 Finland
Dry eye syndrome
2.4
6.8
50
229
TDM10
NOMESCO Finland
Puncture of maxillary antrum
4.2
6.7
18
45
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.4
6.7
24
74
R06AE07
ATC
cetirizine; oral
1.8
6.5
141
953
SXA10
NOMESCO Finland
Oral mucosal sampling
7.6
6.5
14
19
SAA04
NOMESCO Finland
Special examination of mouth
3.3
6.5
25
81
S18
ICPC
Laceration/cut
1.8
6.4
179
1304
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.8
6.3
19
52
L12.2
ICD-10 Finland
Chronic bullous disease of childhood
+∞
6.3
6
*
L51.19
ICD-10 Finland
Other bullous erythema multiforme
+∞
6.3
6
*
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
6.5
6.2
15
24
SPAT1285
SPAT
Provision of consultation response
3.1
6.1
26
89
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.6
6.0
37
155
B35.3
ICD-10 Finland
Tinea pedis
3.3
6.0
23
74
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
6.0
124
823

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
198
25
189.01
307.65
3.1
1.2
30.40
—
u/ml
—
105
0
144
25
99.40
269.03
1.8
1.3
493.91
—
titre
—
46
0
98
140
9.44
69.22
1.5
1.2
—
—
—
0
0
270
1561
4.58
31.11
12.6
5.9
1.75
1.77
e9/l
0.19
242
1368
267
1537
4.47
30.81
12.5
5.9
0.62
0.61
e9/l
0.57
238
1300
267
1549
4.41
30.17
12.6
5.9
0.04
0.04
e9/l
0.49
238
1313
252
1426
3.99
29.03
13.6
6.1
24.89
25.53
%
0.40
245
1340
249
1415
3.86
28.10
13.5
6.0
0.66
0.64
%
0.24
242
1310
205
1034
3.49
27.95
13.1
5.8
—
—
—
0
0
266
1584
4.15
27.84
13.0
6.1
0.22
0.19
e9/l
2.04
241
1367
248
1415
3.80
27.60
13.8
6.1
9.02
9.00
%
0.04
241
1315
248
1419
3.79
27.39
13.6
6.0
3.02
2.81
%
0.76
242
1316
275
1704
4.25
26.45
14.8
9.8
4.37
4.23
e9/l
0.47
248
1488
95
314
3.81
24.83
2.9
1.9
348.34
389.67
nmol/l
1.04
88
289
90
366
2.99
16.18
2.2
1.4
—
—
—
0
0
169
1003
2.37
13.54
4.9
4.5
—
—
—
0
0
100
475
2.57
13.03
3.9
2.7
2.05
1.78
%
1.99
94
427
238
1689
2.37
11.92
6.8
6.6
13.17
12.11
umol/l
0.24
229
1597
291
2272
2.98
11.80
11.3
8.5
88.81
81.18
u/l
1.08
282
2137
81
367
2.59
11.49
1.5
1.3
572.73
514.73
titre
0.08
22
91
80
366
2.55
11.10
3.7
2.8
81.22
67.99
e9/l
2.02
57
279
79
362
2.54
10.91
3.0
1.8
—
—
—
0
0
213
1509
2.11
9.79
6.1
4.9
33.54
34.95
g/l
2.68
203
1408
71
327
2.48
9.61
1.6
3.0
65.57
66.35
g/l
0.38
65
299
148
929
2.05
9.34
3.2
2.3
3.06
3.21
mg/l
0.30
128
797
107
620
2.06
8.20
3.6
2.5
12.66
12.20
umol/l
0.28
102
575
61
285
2.39
7.93
1.3
2.6
—
—
—
0
0
239
1859
1.97
7.39
6.3
5.1
7.31
6.84
mmol/l
1.59
233
1767
167
1160
1.87
7.31
2.7
2.3
—
—
—
0
0
185
1337
1.84
7.05
3.9
3.1
142.00
138.26
ug/l
0.10
171
1220
216
1645
1.86
6.88
4.6
4.5
0.03
0.94
estimate
0.48
33
324
146
987
1.84
6.85
3.4
2.5
55.09
67.20
u/l
1.09
133
913
214
1630
1.85
6.76
4.5
4.4
0.00
10.01
estimate
0.80
37
350
32
117
2.92
6.75
1.6
1.5
2.83
9.84
iu/ml
—
6
32
220
1692
1.86
6.71
8.9
7.1
1.21
1.21
mmol/l
0.04
189
1458
92
539
1.97
6.67
3.5
2.5
21.66
21.69
%
0.01
86
503
153
1059
1.81
6.58
2.0
1.8
20.47
20.86
nmol/l
0.11
133
876
254
2054
1.94
6.52
6.9
5.4
6270.57
2712.42
e6/l
—
7
45
28
98
3.02
6.37
1.5
1.2
—
—
—
0
0
11
10
11.32
6.34
2.1
1.0
8.48
10.06
ug/l
—
11
10
95
576
1.90
6.17
3.6
2.5
2.29
2.25
g/l
0.22
90
530
210
1617
1.78
6.12
4.5
4.4
0.00
0.00
estimate
-0.00
36
334
252
2060
1.87
5.91
6.4
5.0
—
2.34
—
0
6
66
359
2.04
5.83
2.4
2.9
9.66
9.66
umol/l
0.00
57
320
197
1502
1.74
5.82
2.8
2.3
93.47
94.96
pmol/l
0.16
116
802
210
1639
1.74
5.62
23.4
17.4
1.37
1.33
inr
0.43
182
1366
51
255
2.18
5.60
5.7
4.4
0.55
0.60
%
0.07
28
82
98
617
1.83
5.59
7.6
5.2
—
—
—
0
0
82
495
1.87
5.32
2.6
1.9
—
—
—
0
0
92
576
1.82
5.31
2.9
3.2
0.79
0.82
mmol/l
1.24
85
542
105
684
1.78
5.31
1.9
1.7
1175.42
1174.13
nmol/l
0.01
85
512
97
621
1.79
5.19
1.3
1.2
1.45
1.38
u/ml
0.04
32
148
293
2555
2.08
5.18
6.3
5.5
2.13
2.00
mu/l
0.85
270
2304
314
2819
2.54
5.08
35.9
24.0
138.99
139.57
mmol/l
3.13
308
2766
314
2820
2.54
5.06
36.2
24.1
3.99
4.00
mmol/l
0.30
308
2764
26
100
2.73
5.02
1.2
1.2
—
2.30
—
0
8
63
360
1.92
4.81
5.7
2.9
4.22
4.97
e9/l
0.52
50
303
150
1108
1.63
4.64
4.4
3.6
—
—
—
0
0
196
1549
1.63
4.59
7.7
6.3
1.20
1.21
mmol/l
0.93
175
1418
15
37
4.19
4.46
1.2
1.3
—
—
—
0
0
105
714
1.68
4.45
2.0
1.8
82759049.78
9727398.62
pmol/l
0.42
87
586
299
2662
2.04
4.44
6.5
5.8
6.19
6.10
mmol/l
0.45
282
2408
176
1362
1.61
4.44
3.1
2.5
80.38
78.42
nmol/l
0.30
159
1194
55
309
1.93
4.40
1.7
1.5
—
—
—
0
0
48
258
2.00
4.36
5.0
4.5
0.00
0.13
%
1.76
23
76
304
2727
2.11
4.35
32.7
19.6
26.23
26.52
mg/l
0.06
279
2318
50
273
1.98
4.34
5.5
4.4
0.66
0.84
%
0.35
25
91
205
1654
1.61
4.28
4.5
3.3
73.04
51.31
u/l
1.35
196
1531
12
25
4.94
4.22
1.4
1.4
22.62
32.32
ng/l
0.28
12
25
125
902
1.61
4.14
8.9
6.5
—
—
—
0
0
158
1209
1.57
4.07
3.6
3.6
2328.81
1658.08
ng/l
0.66
140
1060
293
2611
1.90
4.04
9.1
7.3
42.08
40.49
mmol/mol
1.62
276
2425
105
731
1.63
4.00
5.0
4.6
1.02
1.02
kg/l
1.45
76
499
47
259
1.95
3.98
1.9
1.4
—
—
—
0
0
84
554
1.69
3.94
1.7
1.5
2.78
2.60
g/l
0.32
59
315
250
2138
1.64
3.92
4.9
4.3
15.19
15.07
pmol/l
0.31
231
1905
56
333
1.82
3.76
1.8
1.7
—
—
—
0
0
93
646
1.61
3.53
6.5
4.4
47.94
237.96
ng/l
2.41
81
555
45
256
1.87
3.47
3.2
2.8
5.92
6.04
ph
0.46
30
185
111
808
1.56
3.44
3.1
3.0
373.61
355.86
umol/l
0.73
103
693
137
1045
1.52
3.42
2.8
2.1
156.42
200.32
u/l
0.82
130
984
9
18
5.11
3.39
2.6
1.3
11.97
5.46
umol/l
—
9
11
22
97
2.36
3.27
1.5
1.2
0.26
0.24
g/l
0.58
22
92
33
173
2.01
3.23
2.7
2.6
—
—
—
0
0
292
2645
1.75
3.19
5.5
5.4
4.33
4.44
mmol/l
1.08
272
2419
163
1305
1.48
3.15
4.5
4.0
6.35
6.22
ph
0.69
85
716
149
1173
1.48
3.13
3.3
3.3
2.33
2.35
mmol/l
1.66
133
1056
21
93
2.34
3.10
1.2
1.7
—
—
—
0
0
161
1292
1.47
3.04
19.5
12.9
0.00
0.00
e9/l
0.72
129
1055
142
1115
1.47
2.99
3.9
3.6
759.76
113.22
e6/l
0.46
107
863
5
5
10.12
2.99
1.6
1.2
—
—
—
0
0
300
2750
1.79
2.99
27.7
17.6
—
—
—
0
0
153
1222
1.46
2.93
4.8
4.5
0.00
0.02
estimate
0.78
30
285
10
27
3.78
2.90
1.0
1.1
—
—
—
0
0
295
2698
1.72
2.87
6.2
6.3
2.49
2.52
mmol/l
0.22
274
2455
45
272
1.75
2.87
6.1
4.8
0.00
0.20
%
0.98
20
75
62
412
1.62
2.78
4.6
6.6
0.93
1.06
mmol/l
0.11
48
341
62
414
1.61
2.73
1.3
1.3
—
—
—
0
0
9
24
3.82
2.69
1.6
1.3
—
—
—
0
0
30
163
1.92
2.68
5.1
4.1
—
—
—
0
0
152
1228
1.43
2.67
4.9
4.3
139.16
101.52
e6/l
0.41
105
893
141
1124
1.44
2.67
4.4
4.0
14.60
9.45
mg/mmol
0.62
106
705
11
35
3.21
2.67
3.1
2.1
0.84
0.59
mmol/l
0.10
11
35
62
418
1.59
2.62
4.7
6.6
7.41
7.42
ph
0.38
37
254
9
25
3.67
2.59
1.0
1.2
—
—
—
0
0
36
210
1.80
2.59
1.3
1.2
—
—
—
0
0
5
7
7.23
2.55
1.4
3.1
—
—
—
0
0
55
363
1.61
2.54
4.7
3.7
7.37
7.38
ph
0.40
31
221
28
154
1.89
2.42
2.3
1.9
2.60
3.71
ug/l
0.17
22
129
6
12
5.07
2.41
1.0
1.0
—
—
—
0
0
5
8
6.32
2.38
1.6
1.3
37.40
32.75
%
—
5
8
7
17
4.18
2.37
2.1
1.7
39.67
35.65
%
—
7
17
136
1096
1.40
2.35
3.8
3.4
68.56
49.36
mg/l
0.52
109
718
165
1378
1.38
2.29
5.5
4.5
352.78
64.80
ng/l
0.45
133
1099
132
1063
1.40
2.28
6.8
4.3
7.40
7.40
ph
0.38
99
759
6
13
4.68
2.28
2.0
2.3
450.00
892.31
u/ml
—
6
13
12
48
2.56
2.21
1.9
1.5
29.29
30.70
g/l
0.15
12
43
137
1118
1.38
2.16
3.9
3.3
6.37
7.01
mmol/l
1.12
122
936
47
311
1.59
2.16
4.7
4.4
7.41
7.35
ph
1.59
33
217
10
36
2.83
2.15
4.0
3.8
—
—
—
0
0
8
25
3.25
2.11
1.0
1.1
—
—
—
0
0
284
2622
1.51
2.10
5.5
5.3
1.41
1.47
mmol/l
1.55
262
2375
124
1000
1.38
2.09
2.9
2.8
—
—
—
0
0
10
37
2.75
2.08
1.2
1.2
—
—
—
0
0
5
10
5.06
2.08
1.0
1.0
—
—
—
0
0
10
38
2.68
2.02
1.0
1.1
—
—
—
0
0
47
317
1.56
2.00
2.4
2.8
4.81
6.16
ug/l
0.43
38
275
23
127
1.87
1.99
1.9
3.8
1.75
3.02
ratio
0.77
12
73
36
229
1.64
1.94
5.6
3.9
7.41
7.42
ph
0.66
31
186
18
92
2.01
1.94
1.8
1.4
279.64
289.56
ug/g
0.06
11
54
163
1387
1.34
1.90
3.2
3.0
—
—
estimate
—
0
0
115
930
1.36
1.87
4.4
4.5
0.00
0.01
estimate
0.50
30
303
5
12
4.21
1.83
4.6
5.1
—
—
—
0
0
49
342
1.51
1.80
1.4
1.3
—
—
—
0
0
5
13
3.89
1.72
4.6
4.8
—
—
—
0
0
107
866
1.34
1.72
3.8
3.9
0.00
0.10
estimate
0.55
26
269
271
2508
1.40
1.71
4.8
4.5
1.30
1.25
mmol/l
0.45
249
2253
16
83
1.97
1.67
1.8
2.9
95.00
105.19
ug/min
—
9
55
116
956
1.32
1.64
4.1
3.5
0.29
0.46
e6/l
1.33
86
710
21
121
1.78
1.62
6.0
3.0
242.13
254.52
mg/l
0.07
15
42
8
32
2.54
1.60
3.0
3.1
—
—
—
0
0
43
300
1.50
1.59
1.8
2.2
0.00
0.05
estimate
—
6
56
6
20
3.03
1.59
1.0
1.2
—
—
—
0
0
10
44
2.31
1.57
1.3
1.1
—
—
—
0
0
71
546
1.38
1.57
3.6
3.4
5.05
2.35
e6/l
0.75
33
277
23
138
1.72
1.56
1.2
1.2
—
—
—
0
0
8
33
2.46
1.54
1.5
1.2
—
—
—
0
0
23
139
1.70
1.52
1.2
1.1
—
—
—
0
0
9
37
2.47
1.49
1.3
1.4
—
—
—
0
0
7
28
2.53
1.46
1.3
1.3
—
—
—
0
0
6
22
2.76
1.44
1.0
1.0
—
—
—
0
0
31
207
1.55
1.41
2.8
2.6
0.97
0.64
%
0.87
31
207
6
23
2.64
1.37
1.3
1.1
—
—
—
0
0
84
677
1.32
1.37
1.9
1.7
1.29
1.55
mg/l
0.52
70
545
10
47
2.16
1.35
1.1
1.3
—
—
—
0
0
9
42
2.17
1.34
1.1
2.6
—
—
—
0
0
42
304
1.44
1.31
3.0
2.4
209.52
152.95
ug/g
0.47
33
234
6
24
2.53
1.31
1.7
1.6
183.83
85.25
ng/l
—
6
24
224
2050
1.27
1.30
4.7
4.8
—
0.17
—
0
6
42
305
1.43
1.29
3.2
2.6
79.14
32.99
u/l
0.64
37
247
5
18
2.80
1.29
1.2
2.1
5.86
7.97
mmol/l
—
5
12
5
18
2.80
1.29
1.2
1.1
—
—
—
0
0
9
44
2.07
1.27
1.3
1.6
—
—
—
0
0
96
798
1.28
1.24
3.1
2.8
6.71
5.22
e6/l
0.34
89
730
106
898
1.26
1.17
4.1
3.5
—
0.00
estimate
—
0
6
40
294
1.41
1.17
7.1
8.0
—
—
—
0
0
5
20
2.52
1.15
1.0
1.7
—
—
—
0
0
13
73
1.81
1.12
1.7
1.2
—
92.22
—
0
9
117
1012
1.24
1.07
6.0
6.1
11.53
2.77
ug/l
0.48
109
893
22
146
1.54
1.06
1.4
1.4
—
—
—
0
0
50
389
1.33
1.05
1.4
1.4
—
—
—
0
0
23
155
1.52
1.04
2.1
2.9
—
—
—
0
0
83
694
1.26
1.02
3.7
3.3
476.77
529.03
mosm/kgh2o
2.02
74
602
25
173
1.48
1.01
1.3
1.4
—
—
—
0
0
0
29
0.00
0.98
0.0
3.8
—
0.83
—
0
29
7
36
1.96
0.97
1.3
2.9
381.86
671.03
mg
—
7
36
25
175
1.46
0.96
1.2
1.3
—
—
—
0
0
6
27
2.24
0.94
2.8
2.3
—
—
—
0
0
6
32
1.89
0.82
1.0
1.1
—
13.60
—
0
6
5
25
2.01
0.73
1.2
1.2
88.40
95.04
pmol/l
—
5
25
5
25
2.01
0.73
2.4
2.1
—
—
—
0
0
53
439
1.25
0.72
1.4
1.3
6.59
11.83
u/ml
0.38
20
160
9
59
1.54
0.69
1.3
1.3
—
—
—
0
0
7
42
1.68
0.69
1.1
1.5
—
—
—
0
0
7
42
1.68
0.69
1.1
1.5
—
—
—
0
0
7
42
1.68
0.69
1.1
1.5
—
—
—
0
0
7
42
1.68
0.69
1.1
1.5
—
—
—
0
0
5
27
1.86
0.68
1.6
2.2
—
206.00
—
0
7
5
28
1.80
0.66
1.6
1.3
—
—
—
0
0
5
30
1.68
0.61
1.4
1.7
6.02
8.19
mmol/l
—
5
30
30
237
1.29
0.61
3.9
3.1
127.73
126.59
g/l
0.11
30
231
21
157
1.36
0.60
2.0
1.9
—
—
—
0
0
8
53
1.52
0.59
1.0
1.2
—
—
—
0
0
8
54
1.49
0.57
3.1
3.2
—
—
—
0
0
6
37
1.63
0.56
2.3
1.9
221.17
200.53
pmol/l
—
6
32
9
60
1.51
0.54
1.3
1.3
—
—
—
0
0
9
64
1.42
0.52
1.0
1.1
—
—
—
0
0
28
225
1.27
0.51
3.8
3.9
—
—
—
0
0
17
128
1.35
0.48
1.2
1.6
—
—
—
0
0
7
46
1.53
0.48
4.6
2.4
4.89
5.03
e9/l
—
7
46
14
102
1.39
0.48
3.1
1.4
0.65
0.33
mg/l
—
6
38
13
176
0.73
0.47
3.1
4.0
36.92
36.90
°c
0.06
13
176
28
228
1.25
0.47
1.6
1.6
—
—
—
0
0
7
49
1.44
0.46
2.9
7.9
8.29
6.60
mmol/l
—
7
40
7
50
1.41
0.45
2.4
2.0
12.00
10.16
mmol/l
—
7
50
10
69
1.46
0.44
7.2
3.1
—
—
—
0
0
124
1154
1.12
0.42
5.0
4.2
—
0.80
—
0
5
5
33
1.52
0.41
1.0
1.5
—
—
nmol/l
—
0
0
8
61
1.32
0.40
1.1
1.6
—
—
—
0
0
54
482
1.14
0.36
1.6
1.3
18.98
33.63
iu/ml
2.18
18
164
32
280
1.16
0.29
1.5
1.5
—
—
—
0
0
8
64
1.26
0.27
4.1
2.7
61.00
60.51
%
—
8
64
44
399
1.12
0.24
4.4
4.4
4.76
38.71
ug/l
1.09
35
346
0
11
0.00
0.21
0.0
3.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
0.12
—
0
5
0
10
0.00
0.21
0.0
5.7
—
48.75
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
3.3
—
7.24
—
0
12
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
48
1.25
0.20
1.2
1.1
—
—
—
0
0
11
90
1.23
0.19
1.1
1.1
—
—
—
0
0
8
69
1.16
0.16
1.5
1.3
—
—
—
0
0
79
754
1.06
0.15
3.5
3.0
2.48
2.46
mmol/l
0.58
71
676
83
863
0.95
0.13
3.5
3.6
—
—
—
0
0
27
250
1.09
0.11
1.3
1.6
—
—
—
0
0
5
44
1.14
0.10
3.4
2.0
89.12
89.11
%
—
5
44
5
44
1.14
0.10
1.4
1.2
1.51
1.63
g/l
—
5
44
5
47
1.06
0.09
1.4
1.2
0.72
0.85
g/l
—
5
47
6
56
1.07
0.08
3.3
2.5
—
—
—
0
0
6
70
0.85
0.07
3.2
2.5
5.48
9.59
pmol/l
—
6
70
115
1128
1.03
0.07
2.1
1.9
1.29
1.28
mmol/l
0.07
102
920
16
148
1.09
0.06
4.3
3.0
25.56
46.52
u/ml
1.13
16
143
56
576
0.97
0.05
3.1
3.4
1.59
0.81
ug/l
0.58
42
407
11
100
1.10
0.05
7.5
6.1
—
—
—
0
0
10
94
1.07
0.01
1.1
1.2
—
—
—
0
0
23
233
0.99
0.00
4.0
4.5
—
—
—
0
0
71
713
0.99
0.00
1.3
1.3
—
—
—
0
0
5
56
0.89
0.00
3.8
2.7
104.40
105.89
mmol/l
—
5
56
5
56
0.89
0.00
3.8
2.7
4.04
4.03
mmol/l
—
5
56
0
9
0.00
-0.00
0.0
19.6
—
1047.22
—
0
9
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
9
99
0.91
-0.00
1.3
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
13.48
—
0
5
5
50
1.00
-0.00
1.4
1.2
—
—
—
0
0
5
57
0.88
-0.00
1.0
1.1
—
—
—
0
0
9
91
0.99
-0.00
12.0
11.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
159.46
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
39.40
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
18.30
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
55.40
—
0
5
5
53
0.94
-0.00
1.8
1.3
20.94
28.59
iu/l
—
5
46
5
55
0.91
-0.00
3.8
2.7
1.20
1.20
mmol/l
—
5
55
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.02
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.7
—
6.68
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
58.17
—
0
6

Mortality – FinRegistry

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Association

Association between endpoint L12_PEMPHIGOID_NAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_PEMPHIGOID_NAS 1.903 [1.56, 2.32] < 0.001
Birth year 0.991 [0.98, 1.0] 0.044

During the follow-up period (1.1.1998 — 31.12.2019), 546 out of 1148 females with L12_PEMPHIGOID_NAS died.

Males

Parameter HR [95% CI] p-value
L12_PEMPHIGOID_NAS 2.036 [1.5, 2.76] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 407 out of 732 males with L12_PEMPHIGOID_NAS died.

Mortality risk

Mortality risk for people of age

years, who have L12_PEMPHIGOID_NAS.

N-year risk Females Males
1 0.148% 0.367%
5 1.004% 2.224%
10 2.413% 5.341%
15 4.364% 10.53%
20 7.81% 17.358%

Relationships between endpoints

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Index endpoint: L12_PEMPHIGOID_NAS – Other and unspecified pemphigoid

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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