No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
683 |
4. Check minimum number of eventsNone |
683 |
5. Include endpointsNone |
683 |
6. Filter based on genotype QC (FinnGen only) |
614 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H74
- Name in latin
- Morbus adhaesivus auris mediae
Similar endpoints
↥List of similar endpoints to
Adhesive middle ear disease
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7161 | 3318 | 3824 |
| Only index persons | 6710 | 3122 | 3588 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.10 | 0.11 |
| Only index persons | 0.13 | 0.11 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 23.56 | 31.19 | 16.81 |
| Only index persons | 23.60 | 31.18 | 17.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 614 | 344 | 270 |
| Unadjusted period prevalence (%) | 0.12 | 0.12 | 0.12 |
| Median age at first event (years) | 42.89 | 40.43 | 46.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 644
- Matched controls
- 6440
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
UDC00
NOMESCO Finland
Ear microscopy
21.9
312.0
279
217
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
307.7
603
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
995.2
272.2
248
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
763.2
225.1
209
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
15.7
217.4
222
209
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
86.6
180.9
96
13
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
59.7
178.5
101
20
Z01.1
ICD-10 Finland
Examination of ears and hearing
9.9
178.2
278
458
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
1983.3
162.7
151
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
152.3
140
*
H66.9
ICD-10 Finland
Otitis media, unspecified
12.1
149.6
172
188
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
71.7
139.3
76
12
DFF00
NOMESCO Finland
Pure tone audiometry
8.7
125.3
193
303
H68.1
ICD-10 Finland
Obstruction of Eustachian tube
32.7
118.8
78
27
H65.2
ICD-10 Finland
Chronic serous otitis media
320.0
108.5
107
*
H65.0
ICD-10 Finland
Acute serous otitis media
32.8
99.3
65
22
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
55.7
98.1
56
11
4122
FHL
Tympanostomy (tympanic tube)
284.8
97.6
97
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
88.6
83
*
EMB30
NOMESCO Finland
Adenotomy
12.9
80.8
82
72
DC1AD
NOMESCO Finland
Temporalbone CT
177.1
75.9
78
5
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
38.9
75.8
47
13
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
4.2
71.4
336
1328
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
31.4
66.7
44
15
DCD00
NOMESCO Finland
Myringoplasty
+∞
65.8
62
*
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
633.9
59.7
58
*
DGW00
NOMESCO Finland
Dilatation of eustachian tube
+∞
59.3
56
*
4451
FHL
Guitar cutting
11.0
55.7
62
62
DAX08
NOMESCO Finland
Fitting of hearing aid
7.0
55.5
91
147
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
74.6
54.2
61
9
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
6.6
53.8
94
162
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
14.2
53.4
50
38
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.3
53.2
173
510
S02CA02
ATC
flumetasone and antiinfectives; otic
7.1
52.1
84
133
Z97.4
ICD-10 Finland
Presence of external hearing-aid
7.5
51.6
79
118
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
276.4
50.9
51
*
3851A
ICD-9 Finland
Other disorders of middle ear and mastoid, Adhesive middle ear disease
+∞
46.4
44
*
DCD10
NOMESCO Finland
Tympanoplasty
+∞
45.3
43
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
6.2
41.6
76
136
H60.9
ICD-10 Finland
Otitis externa, unspecified
4.8
41.3
105
253
H60.8
ICD-10 Finland
Other otitis externa
7.8
40.9
59
82
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
63.2
40.8
47
8
TDA90
NOMESCO Finland
Removal wax from ear
15.2
40.2
36
25
H66
ICD-10 Finland
Suppurative and unspecified otitis media
8.1
35.3
49
65
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
41.8
34.8
43
11
DFF15
NOMESCO Finland
Speech audiometry
5.6
33.3
67
131
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
7.2
32.7
50
74
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
31.5
30
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
6.9
31.1
50
78
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
30.5
29
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
29.4
28
*
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
+∞
29.4
28
*
H60.3
ICD-10 Finland
Other infective otitis externa
7.5
28.7
42
59
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
+∞
28.3
27
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.9
27.8
89
253
H66.1
ICD-10 Finland
Chronic tubotympanic suppurative otitis media
+∞
27.3
26
*
H04
ICPC
Ear discharge
6.2
27.0
48
83
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.4
25.3
398
2587
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
+∞
24.1
23
*
H92.0
ICD-10 Finland
Otalgia
3.9
23.9
76
214
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
+∞
23.1
22
*
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
+∞
23.1
22
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
+∞
23.1
22
*
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
+∞
22.0
21
*
R01AD08
ATC
fluticasone; nasal
2.4
21.8
221
1171
H72.8
ICD-10 Finland
Other perforations of tympanic membrane
227.4
21.7
22
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.9
21.7
69
194
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.0
21.6
106
393
R5120
NOMESCO Finland
Preparation of an aid
5.8
21.3
40
73
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
20.9
20
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
+∞
20.9
20
*
J35.2
ICD-10 Finland
Hypertrophy of adenoids
5.3
20.5
42
83
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
19.9
19
*
R4135
NOMESCO Finland
Rehabilitation for hearing problems
8.0
19.7
27
35
4742A
ICD-9 Finland
Chronic disease of tonsils and adenoids, Adenoid vegetations
7.0
18.8
29
43
1450
FHL
Otomicroscopy
31.1
18.4
24
8
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
20.1
18.3
27
14
50099
ICD-8 Finland
Hypertrophy of tonsils and adenoids
3.3
17.6
71
233
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
184.9
17.6
18
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
16.7
16
*
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
+∞
16.7
16
*
R01BA52
ATC
pseudoephedrine, combinations; oral
2.2
16.7
183
985
R01AD09
ATC
mometasone; nasal
2.0
16.5
317
2100
ZXC10
NOMESCO Finland
Use of laser
6.4
16.0
27
44
H01
ICPC
Ear pain/earache
2.5
15.7
115
519
DEB10
NOMESCO Finland
Attico-antro-mastoidectomy
+∞
15.7
15
*
ZXA10
NOMESCO Finland
Bilateral
2.3
15.6
133
644
DEB30
NOMESCO Finland
Radical mastoidectomy
163.8
15.5
16
*
H71
ICPC
Acute otitis media/myringitis
7.0
14.9
23
34
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
14.6
14
*
DCB10
NOMESCO Finland
Freeing of adhesions of middle ear
+∞
14.6
14
*
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
+∞
14.6
14
*
H61.2
ICD-10 Finland
Impacted cerumen
3.1
14.5
64
222
J01DA08
ATC
[U] cefaclor
2.4
14.4
117
552
J01DA01
ATC
[U] cefalexin
1.9
14.4
395
2903
J01DA06
ATC
[U] cefuroxime
2.5
14.4
105
473
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
5.5
14.3
28
53
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
13.6
13
*
H29
ICPC
Ear symptom/complaint other
2.4
12.7
93
418
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
71.3
12.6
14
*
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
12.5
12
*
DCW00
NOMESCO Finland
Removal of ventilating tube from tympanic membrane
+∞
12.5
12
*
DCA30
NOMESCO Finland
Exploration of middle ear
+∞
12.5
12
*
TDC10
NOMESCO Finland
Removal of ventilating tube from tympanic membrane
+∞
12.5
12
*
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
+∞
12.5
12
*
SPAT1263
SPAT
Sampling
1.8
12.5
291
1998
4141
FHL
Myringoplasty (also for reasons other than inflammation)
132.5
12.5
13
*
H69.8
ICD-10 Finland
Other specified disorders of Eustachian tube
21.8
12.1
17
8
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
4.0
12.0
34
88
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
+∞
11.5
11
*
SPAT1301
SPAT
No procedures
1.9
11.5
216
1380
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.2
11.4
46
151
H69.0
ICD-10 Finland
Patulous Eustachian tube
20.5
11.2
16
8
J01FA10
ATC
azithromycin; systemic
1.8
11.2
392
3002
H02
ICPC
Hearing complaint
2.3
10.9
92
439
H72
ICD-10 Finland
Perforation of tympanic membrane
61.0
10.7
12
*
H13
ICPC
Plugged feeling ear
2.0
10.6
128
703
Z96.2
ICD-10 Finland
Presence of otological and audiological implants
+∞
10.4
10
*
DDD10
NOMESCO Finland
Interposition between malleus and stapes
+∞
10.4
10
*
J01DB01
ATC
cefalexin; oral
2.0
10.3
535
4560
H60.4
ICD-10 Finland
Cholesteatoma of external ear
40.7
10.0
12
*
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
4.3
10.0
26
63
H80.9
ICD-10 Finland
Otosclerosis, unspecified
17.0
9.9
15
9
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.1
9.9
27
68
H02AB06
ATC
prednisolone; systemic
1.7
9.6
282
2026
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
9.5
161
986
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
101.5
9.4
10
*
4144
FHL
Mastoidectomy or aticomastoidectomy
+∞
9.4
9
*
H73.8
ICD-10 Finland
Other specified disorders of tympanic membrane
+∞
9.4
9
*
DE2DG
NOMESCO Finland
Acoustic channel very extensive MRI examination with high intensity magnet
+∞
9.4
9
*
J01FA09
ATC
clarithromycin; systemic
1.7
9.0
193
1266
J01MA02
ATC
ciprofloxacin; systemic
1.7
8.9
224
1536
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.4
8.9
32
98
J01CA04
ATC
amoxicillin; systemic
2.0
8.9
545
4743
J35.1
ICD-10 Finland
Hypertrophy of tonsils
3.8
8.7
26
70
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
11.8
8.6
15
13
H91.9
ICD-10 Finland
Hearing loss, unspecified
2.8
8.5
42
155
H92.1
ICD-10 Finland
Otorrhoea
27.9
8.5
11
*
R5140
NOMESCO Finland
Monitoring the use of the aid
2.2
8.5
72
344
4151
FHL
Reoperation for chronic otitis media
+∞
8.3
8
*
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
+∞
8.3
8
*
SPAT1153
SPAT
Removal of sutures
1.7
8.2
180
1184
UDC10
NOMESCO Finland
Tympanoscopy
33.8
8.1
10
*
J20
ICD-10 Finland
Acute bronchitis
2.2
8.0
73
359
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
7.9
7.9
17
22
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.2
7.9
66
314
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
7.6
209
1455
SPAT1043
SPAT
Audiometry
2.2
7.5
64
307
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
7.5
168
1110
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
81.0
7.4
8
*
H61.8
ICD-10 Finland
Other specified disorders of external ear
9.5
7.3
14
15
H74.3
ICD-10 Finland
Other acquired abnormalities of ear ossicles
+∞
7.3
7
*
SPAT1312
SPAT
General health counselling
1.6
7.2
216
1534
ZYC03
NOMESCO Finland
Remote contact, text-based
20.3
7.1
10
5
DDA00
NOMESCO Finland
Stapedotomy
14.0
6.9
11
8
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
6.9
93
527
S18
ICPC
Laceration/cut
1.6
6.9
280
2129
H61.3
ICD-10 Finland
Acquired stenosis of external ear canal
40.5
6.8
8
*
DFF10
NOMESCO Finland
Measurement of acoustic impedance (tympanometry and reflex testing)
22.8
6.7
9
*
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.8
6.7
102
602
J01AA02
ATC
doxycycline; systemic
1.6
6.6
429
3606
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.9
6.6
87
490
J01DA09
ATC
[U] cefadroxil
1.7
6.6
156
1042
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
6.5
270
2053
R01AD05
ATC
budesonide; nasal
2.3
6.5
48
216
R01AD12
ATC
fluticasone furoate; nasal
1.6
6.4
199
1416
4145
FHL
Tympanomastoidectomy, includes possible tympanoplasty
70.5
6.4
7
*
H80.8
ICD-10 Finland
Other otosclerosis
70.5
6.4
7
*
R01BA51
ATC
phenylpropanolamine, combinations; oral
1.8
6.4
96
562
EMB10
NOMESCO Finland
Tonsillectomy
2.3
6.4
47
212
DE2BG
NOMESCO Finland
Acoustic channel MRI examination with high intensity magnet
8.3
6.4
13
16
A05
ICPC
Feeling ill
2.1
6.3
62
315
3810A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Acute nonsuppurative otitis media
+∞
6.3
6
*
Q90.9
ICD-10 Finland
Down syndrome, unspecified
+∞
6.3
6
*
3824A
ICD-9 Finland
Suppurative and unspecified otitis media, Unspecified suppurative otitis media
+∞
6.3
6
*
DCA40
NOMESCO Finland
Fat patching or other similar technique without opening of tympanic membrane
+∞
6.3
6
*
H74.4
ICD-10 Finland
Polyp of middle ear
+∞
6.3
6
*
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.2
6.2
50
234
SPAT1310
SPAT
Counselling related to known health issue
1.6
6.2
208
1507
H02AB04
ATC
methylprednisolone; systemic
1.9
6.1
79
441
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
12.7
6.1
10
8
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
3.3
6.1
22
68
H60
ICD-10 Finland
Otitis externa
2.3
6.0
43
191
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.3
6.0
45
204
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
109
521
2.31
12.99
7.3
6.8
—
—
—
0
0
50
186
2.83
9.98
2.0
1.7
—
—
—
0
0
51
201
2.67
9.13
1.9
1.9
—
—
—
0
0
96
576
1.78
5.92
4.9
4.4
31.27
31.34
%
0.02
59
375
67
359
1.97
5.86
2.8
2.3
3.96
7.86
ug/l
1.92
54
322
249
1931
1.47
5.18
4.0
3.6
74.15
34.68
ng/l
0.40
173
1272
456
3977
1.50
5.13
7.2
8.1
76.99
78.71
u/l
0.40
426
3764
51
266
2.00
4.83
4.3
3.4
45.43
48.62
%
0.47
51
261
186
1383
1.48
4.70
3.4
3.2
1156.68
1168.47
ng/l
0.02
149
1162
283
2283
1.43
4.64
15.2
12.8
1.29
1.22
inr
1.25
224
1909
277
2237
1.42
4.46
3.9
5.2
35.75
36.23
g/l
0.64
258
2111
539
4923
1.58
4.43
5.1
4.6
5.94
5.82
mmol/l
1.08
485
4545
577
5365
1.73
4.35
15.6
14.5
24.46
23.13
mg/l
0.40
501
4354
219
1704
1.43
4.31
3.2
2.7
50.10
62.05
u/l
2.45
203
1589
369
3146
1.40
4.28
4.1
5.0
6.77
6.59
mmol/l
0.72
341
2933
597
5614
1.87
4.21
11.2
11.2
28.19
26.57
u/l
0.79
572
5477
122
851
1.53
4.14
1.7
1.9
—
—
—
0
0
20
74
2.76
4.12
1.2
1.3
—
—
—
0
0
52
291
1.86
4.04
2.9
3.5
1.15
1.76
mmol/l
0.47
36
207
570
5311
1.64
3.91
17.1
16.5
139.66
139.58
mmol/l
0.38
559
5200
470
4212
1.43
3.89
4.2
4.2
14.85
14.71
pmol/l
0.64
418
3849
112
779
1.53
3.84
1.6
1.7
1230.33
1210.27
nmol/l
0.07
73
588
569
5314
1.61
3.68
16.9
16.6
3.95
3.95
mmol/l
0.03
559
5189
21
86
2.49
3.58
1.4
1.2
—
—
—
0
0
52
842
0.58
3.47
3.2
2.9
2.04
2.61
e6/l
0.27
36
395
58
353
1.71
3.43
1.5
1.4
—
—
—
0
0
163
1252
1.40
3.33
2.7
2.7
343.50
342.26
umol/l
0.05
145
1116
266
2211
1.35
3.32
2.0
2.0
98.35
96.34
pmol/l
0.28
140
1147
618
5929
2.05
3.31
23.8
21.8
254.08
251.64
e9/l
0.41
611
5825
618
5932
2.04
3.25
23.6
21.7
90.35
90.40
fl
0.13
613
5883
224
1819
1.35
3.24
3.4
3.5
7.90
8.01
mmol/l
0.12
187
1569
618
5934
2.03
3.22
23.7
21.8
4.56
4.54
e12/l
0.46
610
5815
618
5934
2.03
3.22
23.9
22.2
40.74
41.36
%
0.37
613
5879
519
4789
1.43
3.22
6.5
5.8
39.26
38.56
mmol/mol
0.91
479
4532
440
3954
1.36
3.19
4.8
4.2
11.58
10.71
mm/h
0.75
403
3694
16
61
2.66
3.15
1.6
1.5
—
—
—
0
0
16
61
2.66
3.15
1.6
1.5
—
—
—
0
0
33
173
1.96
3.15
1.2
1.3
—
—
—
0
0
618
5938
2.01
3.14
23.9
21.9
136.97
136.22
g/l
0.62
613
5885
594
5643
1.68
3.13
19.2
18.1
77.93
75.52
umol/l
0.74
588
5583
139
1050
1.41
3.11
1.6
1.7
155000425.29
28491424.67
pmol/l
0.59
120
888
16
62
2.62
3.06
1.6
1.5
—
—
—
0
0
25
120
2.13
3.02
1.6
1.4
7946.75
13974.40
e6/l
0.53
20
86
16
63
2.58
2.97
1.6
1.4
—
—
—
0
0
16
64
2.54
2.89
1.6
1.5
—
—
—
0
0
169
1335
1.36
2.88
4.1
3.9
1.02
1.02
kg/l
0.05
108
881
13
47
2.80
2.83
1.1
1.7
—
—
—
0
0
13
47
2.80
2.83
1.1
1.7
—
—
—
0
0
13
47
2.80
2.83
1.1
1.7
—
—
—
0
0
317
2747
1.30
2.81
5.4
6.6
9.89
11.40
umol/l
3.65
299
2614
203
1655
1.33
2.80
3.9
3.9
0.00
0.00
estimate
0.74
59
629
191
1561
1.32
2.56
4.6
4.4
9.09
9.13
mg/mmol
0.00
116
1000
9
26
3.50
2.49
1.0
1.8
—
—
—
0
0
9
26
3.50
2.49
1.0
1.8
—
—
—
0
0
9
26
3.50
2.49
1.0
1.8
—
—
—
0
0
9
26
3.50
2.49
1.0
1.8
—
—
—
0
0
15
64
2.38
2.40
1.7
1.5
—
—
—
0
0
14
58
2.45
2.38
2.1
2.1
0.03
0.58
mmol/l
0.22
14
58
13
52
2.53
2.37
1.7
2.0
—
—
—
0
0
24
126
1.94
2.33
1.6
1.3
—
—
—
0
0
7
18
3.92
2.25
1.0
1.2
—
—
—
0
0
7
18
3.92
2.25
1.0
1.1
—
—
—
0
0
7
18
3.92
2.25
1.0
1.1
—
—
—
0
0
7
18
3.92
2.25
1.0
1.2
—
—
—
0
0
180
1485
1.29
2.21
1.6
1.6
19.22
20.43
nmol/l
0.46
146
1261
287
2509
1.26
2.20
6.3
7.2
1.21
1.21
mmol/l
0.42
234
2157
279
2433
1.26
2.18
2.4
2.5
73.87
75.05
nmol/l
0.30
242
2213
14
61
2.32
2.16
1.6
1.8
—
—
—
0
0
263
2285
1.26
2.10
3.9
3.6
0.02
0.03
estimate
0.10
50
573
181
1504
1.28
2.10
2.3
2.1
200.01
291.01
u/l
0.48
167
1431
5
10
5.03
2.07
1.0
1.4
—
—
—
0
0
548
5206
1.35
2.01
5.5
5.1
2.68
2.71
mmol/l
0.26
506
4881
29
172
1.72
1.96
1.6
1.4
—
—
—
0
0
542
5150
1.33
1.91
5.0
4.6
4.50
4.59
mmol/l
1.27
504
4844
515
4860
1.30
1.90
4.3
3.9
1.32
1.25
mmol/l
1.55
472
4522
0
51
0.00
1.89
0.0
1.6
—
—
—
0
0
7
22
3.20
1.88
1.3
1.4
—
—
—
0
0
7
22
3.20
1.88
1.0
1.3
—
—
—
0
0
7
22
3.20
1.88
1.3
1.4
—
—
—
0
0
11
46
2.42
1.86
1.7
1.3
—
—
—
0
0
6
17
3.55
1.84
1.0
1.4
81.48
73.66
ng/l
—
6
17
11
47
2.36
1.78
1.7
1.3
—
—
—
0
0
45
643
0.68
1.76
2.1
3.0
6.43
8.34
umol/l
0.55
36
557
6
18
3.35
1.75
1.3
1.3
—
—
—
0
0
6
18
3.35
1.75
1.3
1.3
—
—
—
0
0
6
18
3.35
1.75
1.0
1.1
—
—
—
0
0
123
996
1.29
1.73
1.3
1.3
23.90
28.80
iu/ml
0.19
42
285
65
479
1.40
1.71
3.3
3.4
4.04
4.49
kpa
1.88
65
464
6
19
3.18
1.66
1.0
2.1
—
—
—
0
0
6
19
3.18
1.66
1.0
2.1
—
—
—
0
0
529
5035
1.28
1.65
12.3
13.8
86.90
87.14
ml/min/173m2
0.08
486
4584
537
5127
1.29
1.59
5.0
4.5
1.38
1.44
mmol/l
3.35
495
4802
284
2544
1.21
1.59
2.5
2.8
—
—
estimate
—
0
0
6
20
3.02
1.58
1.0
2.0
—
—
—
0
0
6
20
3.02
1.58
1.2
1.8
—
—
—
0
0
24
145
1.68
1.56
3.0
2.7
1.61
1.48
mmol/l
0.19
24
140
162
1376
1.24
1.53
5.6
5.1
2.11
2.33
ug/l
0.27
142
1234
70
904
0.75
1.52
2.8
2.7
1.41
0.95
e6/l
0.50
53
453
6
21
2.87
1.51
1.3
1.5
—
—
—
0
0
131
1089
1.25
1.49
4.7
4.4
20.03
21.68
%
0.60
59
487
41
285
1.47
1.49
2.7
3.5
0.66
0.61
%
0.53
41
285
72
553
1.34
1.49
3.3
3.9
6.07
5.75
kpa
2.72
72
533
112
915
1.27
1.48
1.3
1.3
3.49
10.89
u/ml
2.14
40
373
51
375
1.39
1.39
2.6
2.4
4842.53
5162.86
u/l
0.04
16
163
24
151
1.61
1.36
1.4
1.4
316.25
297.97
ug/g
0.15
16
82
0
38
0.00
1.34
0.0
1.4
—
85.00
—
0
6
18
105
1.73
1.34
2.0
1.5
—
—
—
0
0
37
518
0.70
1.33
3.8
3.2
—
—
—
0
0
409
3827
1.19
1.31
3.4
3.3
43.45
42.11
u/l
0.15
387
3642
154
1323
1.22
1.30
2.1
2.2
—
—
—
0
0
9
44
2.06
1.27
2.8
3.2
456.56
1051.20
mg
—
9
44
522
5002
1.23
1.27
5.4
5.2
1.84
1.87
mu/l
0.30
476
4661
18
107
1.70
1.27
1.1
1.1
57.72
15.26
au/ml
—
5
40
165
1431
1.21
1.26
1.8
1.7
—
—
—
0
0
153
1758
0.83
1.22
3.2
3.2
93.83
85.99
e6/l
0.03
126
1344
11
56
1.98
1.22
2.2
2.7
18.60
21.80
mg/l
—
5
23
16
262
0.60
1.21
1.9
1.5
—
—
—
0
0
15
249
0.59
1.20
1.3
1.4
—
—
—
0
0
5
20
2.51
1.15
1.4
1.5
—
—
—
0
0
199
1774
1.18
1.11
2.3
3.4
2.37
2.35
mmol/l
0.91
178
1619
19
291
0.64
1.10
1.8
1.6
54.29
61.62
ug/l
0.64
19
258
18
113
1.61
1.06
1.9
2.7
582.80
57.59
ug/min
0.59
11
67
48
369
1.33
1.04
2.6
2.5
73.65
66.06
ml/min/173m2
0.85
26
157
5
22
2.28
1.03
2.2
2.5
—
—
—
0
0
69
559
1.26
1.01
1.9
1.8
388.82
390.32
nmol/l
0.02
62
520
131
1501
0.84
1.01
3.1
3.1
0.17
0.44
e6/l
3.16
107
1093
47
362
1.32
1.01
3.7
4.0
103.53
80.94
ng/l
0.48
39
325
68
551
1.26
1.00
5.0
8.3
5.08
5.10
kpa
0.06
63
528
165
1462
1.17
0.99
2.1
2.3
2.83
2.81
mg/l
0.03
137
1275
25
173
1.46
0.99
1.5
1.3
—
—
—
0
0
11
61
1.82
0.99
1.9
1.6
31.64
32.00
pg
0.10
11
61
0
29
0.00
0.98
0.0
2.4
—
—
—
0
0
0
29
0.00
0.98
0.0
2.4
—
—
—
0
0
101
859
1.21
0.96
2.3
2.9
162.27
139.81
ug/g
0.20
79
687
246
2252
1.15
0.95
5.7
6.5
1.21
1.21
mmol/l
0.12
217
2066
64
520
1.26
0.93
2.4
2.3
12.45
13.79
nmol/l
0.67
59
483
12
195
0.61
0.92
2.3
3.9
43.00
826.89
u/ml
1.09
12
164
337
3162
1.14
0.89
8.8
9.6
4.70
4.08
e9/l
1.57
310
2763
6
29
2.08
0.89
1.8
3.3
1462.00
877.07
u/ml
—
6
29
35
454
0.76
0.84
5.5
7.6
1.37
1.36
mmol/l
0.03
35
441
65
539
1.23
0.81
5.1
8.5
1.23
0.97
mmol/l
0.24
54
447
138
1227
1.16
0.80
1.4
1.8
0.97
1.35
mg/l
1.11
94
932
18
257
0.69
0.78
1.7
2.8
21.61
35.27
u/ml
1.10
18
248
0
26
0.00
0.78
0.0
1.8
—
—
—
0
0
316
2975
1.12
0.75
4.1
3.8
0.00
7.32
estimate
1.07
63
671
13
83
1.58
0.75
1.4
1.5
—
—
—
0
0
44
354
1.26
0.72
1.1
1.0
—
—
—
0
0
10
60
1.68
0.72
1.0
1.1
—
—
—
0
0
23
169
1.37
0.70
1.4
2.1
169.22
560.80
ug/l
0.83
23
158
317
2994
1.12
0.70
4.2
3.8
0.05
0.01
estimate
0.36
56
632
29
222
1.32
0.69
1.7
1.7
7.96
7.43
u/ml
—
9
56
5
28
1.79
0.66
2.2
3.1
0.80
1.07
%
—
5
28
410
3937
1.11
0.65
3.2
3.4
—
—
—
0
0
48
397
1.23
0.64
3.5
3.7
1.22
1.23
mmol/l
0.12
42
341
11
165
0.66
0.63
2.5
2.2
1.86
3.86
iu/l
—
6
65
98
866
1.16
0.63
2.3
2.5
11.48
13.81
umol/l
2.74
93
810
10
63
1.60
0.62
1.2
1.4
—
—
—
0
0
5
30
1.67
0.61
1.0
1.1
1.04
1.07
ratio
—
5
25
78
679
1.17
0.61
3.8
6.1
1.04
1.05
mmol/l
0.09
66
626
29
227
1.29
0.61
1.7
1.8
32.03
39.61
nmol/l
2.17
29
218
455
4691
0.90
0.60
18.8
18.1
333.95
333.32
g/l
0.83
455
4666
8
52
1.55
0.59
1.0
1.1
—
—
—
0
0
10
64
1.57
0.59
1.2
2.6
104.30
106.08
mmol/l
—
10
64
71
623
1.16
0.52
1.5
1.8
—
—
—
0
0
30
242
1.25
0.52
1.3
1.7
1.64
6.70
iu/ml
2.12
11
54
9
64
1.41
0.51
1.2
2.6
1.19
1.19
mmol/l
—
9
64
19
145
1.32
0.49
1.4
1.2
—
—
—
0
0
35
290
1.22
0.48
1.5
1.4
—
—
—
0
0
60
685
0.86
0.48
1.6
1.8
3.55
3.47
ratio
0.20
42
514
45
526
0.84
0.48
1.4
1.6
3.63
3.43
mmol/l
0.47
28
357
67
591
1.15
0.47
1.6
1.9
—
—
—
0
0
13
94
1.39
0.46
1.4
1.7
—
—
—
0
0
8
120
0.66
0.46
1.6
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
19
238
0.79
0.41
2.0
1.8
—
—
—
0
0
18
141
1.28
0.40
1.2
1.6
—
—
—
0
0
14
106
1.33
0.39
1.4
1.5
—
—
—
0
0
82
746
1.11
0.37
2.3
2.4
20.15
23.57
%
1.69
76
708
6
43
1.40
0.35
1.2
1.1
—
—
—
0
0
305
2946
1.07
0.34
4.2
3.7
0.00
0.00
estimate
0.50
61
674
39
444
0.87
0.33
1.2
1.3
78.75
143.70
u/ml
1.24
18
176
24
284
0.84
0.32
1.6
1.4
19.58
18.12
iu/l
0.09
24
237
118
1104
1.08
0.32
2.3
2.3
—
—
—
0
0
87
803
1.10
0.31
2.3
2.4
2.46
2.34
g/l
1.19
82
750
16
129
1.25
0.30
1.3
1.4
—
—
—
0
0
15
120
1.26
0.30
2.3
2.2
7.38
5.12
umol/l
—
10
92
14
111
1.27
0.30
1.7
3.7
27.71
35.47
umol/l
1.60
14
103
164
1559
1.07
0.29
1.4
1.4
0.68
1.70
u/ml
2.63
51
441
11
140
0.78
0.28
1.2
1.3
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
10
129
0.77
0.28
4.6
3.4
0.41
0.35
iu/ml
—
5
69
9
116
0.77
0.27
1.3
1.3
—
—
—
0
0
9
119
0.75
0.27
1.1
1.2
—
—
—
0
0
18
215
0.83
0.27
1.3
2.3
1.55
1.43
g/l
0.24
12
194
9
121
0.74
0.27
2.4
5.4
—
455.56
—
0
16
27
234
1.16
0.27
2.0
1.5
6.93
8.34
u/l
0.32
22
189
13
104
1.26
0.26
1.4
1.5
—
—
—
0
0
43
387
1.12
0.26
1.5
1.7
—
—
—
0
0
181
1736
1.06
0.25
3.2
3.1
0.00
0.01
estimate
1.24
47
546
9
75
1.20
0.25
1.0
1.1
—
—
—
0
0
9
76
1.19
0.24
1.8
1.5
7.52
7.13
mmol/l
—
9
64
105
990
1.07
0.24
2.3
2.8
2.43
2.44
mmol/l
0.34
92
879
9
77
1.17
0.24
1.4
1.4
0.70
24.19
nmol/l
—
9
72
18
152
1.19
0.24
1.3
1.6
—
—
—
0
0
17
143
1.19
0.23
1.0
1.4
511.06
426.07
mg/l
0.55
17
137
5
38
1.32
0.23
1.0
1.4
74.20
76.71
umol/l
—
5
38
5
39
1.28
0.23
1.0
1.1
1489.80
1561.97
miu/ml
—
5
39
5
40
1.25
0.22
1.8
2.4
—
—
—
0
0
30
336
0.89
0.22
1.5
1.5
—
—
—
0
0
5
41
1.22
0.22
1.0
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
5
43
1.16
0.21
4.2
3.4
38.02
56.04
u/ml
—
5
43
15
175
0.85
0.19
1.4
1.1
—
—
—
0
0
15
175
0.85
0.19
1.4
1.1
—
—
—
0
0
11
132
0.83
0.18
1.0
1.2
—
1.00
—
0
8
288
2818
1.04
0.17
3.2
3.1
114.85
105.13
ug/l
0.30
267
2645
81
854
0.94
0.17
3.0
3.4
0.83
0.82
mmol/l
0.35
76
807
7
61
1.15
0.17
1.1
1.1
—
—
—
0
0
26
234
1.12
0.17
1.5
1.8
10.08
3.88
mg/l
0.47
17
168
117
1218
0.95
0.17
2.6
2.6
7.36
5.93
e6/l
0.37
109
1103
23
206
1.12
0.16
1.6
1.6
57.26
52.66
ug/l
0.25
23
206
26
235
1.11
0.16
1.1
1.1
0.86
0.88
g/l
0.17
26
235
9
82
1.10
0.15
1.1
1.1
1.43
1.47
g/l
—
9
75
86
823
1.05
0.14
3.5
3.0
0.79
0.78
ug/l
0.02
54
496
10
117
0.85
0.13
1.1
1.1
—
—
—
0
0
10
117
0.85
0.13
1.5
1.8
—
—
—
0
0
9
108
0.83
0.13
1.8
1.6
—
—
—
0
0
91
946
0.96
0.13
1.5
1.5
—
—
—
0
0
25
229
1.10
0.12
1.1
1.1
1.52
1.51
g/l
0.10
25
229
122
1186
1.04
0.11
2.4
2.5
—
—
—
0
0
12
136
0.88
0.11
1.1
1.2
—
—
—
0
0
27
251
1.08
0.10
1.9
1.7
—
—
—
0
0
5
44
1.14
0.10
1.0
1.1
282.40
271.18
mg/l
—
5
39
5
46
1.09
0.09
1.0
1.1
296.00
221.17
mg/l
—
5
41
10
87
1.15
0.09
6.1
6.5
415.60
375.21
umol/l
—
10
77
5
47
1.06
0.09
1.2
1.3
264.80
190.75
pmol/l
—
5
47
5
48
1.04
0.09
1.0
1.0
—
—
—
0
0
5
48
1.04
0.09
1.2
1.2
97.80
112.46
pmol/l
—
5
48
186
1894
0.97
0.09
3.3
3.5
30.15
32.35
u/l
0.46
177
1795
16
146
1.10
0.08
3.7
2.6
—
—
—
0
0
6
71
0.84
0.07
1.7
1.5
—
—
—
0
0
8
74
1.08
0.07
1.6
1.4
—
—
—
0
0
29
306
0.95
0.07
1.5
1.7
0.22
0.27
mg/l
0.42
16
146
15
163
0.92
0.07
1.1
1.1
0.23
3.41
u/ml
—
7
93
8
93
0.86
0.06
1.0
1.4
—
—
—
0
0
8
93
0.86
0.06
1.0
1.4
—
—
—
0
0
9
102
0.88
0.06
1.2
1.4
—
—
—
0
0
18
193
0.93
0.06
1.6
1.5
—
—
—
0
0
209
2116
0.98
0.06
2.0
1.9
1.49
1.33
mmol/l
1.67
174
1815
35
365
0.96
0.06
1.3
1.3
—
—
—
0
0
10
90
1.11
0.05
1.2
1.2
11.52
23.68
u/l
—
10
75
29
301
0.96
0.04
1.5
1.6
—
—
—
0
0
46
471
0.97
0.03
3.6
4.6
23.16
37.22
ug/l
0.30
37
393
96
973
0.98
0.03
3.0
3.6
184.92
590.08
ng/l
1.53
60
697
72
708
1.02
0.03
2.2
2.2
—
—
—
0
0
11
102
1.08
0.03
2.3
3.0
38.79
8.09
pmol/l
0.42
11
102
18
172
1.05
0.02
1.8
3.0
4.68
3.64
g/l
1.31
13
166
36
352
1.02
0.01
2.5
3.8
4.36
4.69
pmol/l
1.13
31
314
60
608
0.99
0.01
1.9
2.1
—
—
—
0
0
23
237
0.97
0.01
1.8
1.6
—
—
—
0
0
13
133
0.98
0.00
1.0
1.0
0.95
3.11
u/ml
—
5
72
14
138
1.01
0.00
1.1
1.5
—
—
—
0
0
29
288
1.01
0.00
1.2
1.4
158.42
254.98
miu/ml
1.19
16
151
0
5
0.00
0.00
0.0
1.6
—
6.28
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
7
69
1.01
0.00
1.4
1.4
0.23
0.17
nmol/l
—
7
50
8
79
1.01
0.00
1.0
1.2
—
—
—
0
0
9
90
1.00
-0.00
1.2
2.1
—
2160.00
—
0
7
5
50
1.00
-0.00
1.0
1.1
—
94.40
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
7.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
9.7
—
10.63
—
0
7
0
6
0.00
-0.00
0.0
6.3
—
8.12
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
10.17
—
0
6
5
56
0.89
-0.00
1.4
1.3
—
322.73
—
0
11
0
8
0.00
-0.00
0.0
2.1
—
43.00
—
0
8
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_MIDDLEADDH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MIDDLEADDH | 1.106 [0.97, 1.26] | 0.133 |
| Birth year | 0.997 [0.99, 1.01] | 0.534 |
During the follow-up period (1.1.1998 — 31.12.2019), 364 out of 2840 females with H8_MIDDLEADDH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MIDDLEADDH | 0.981 [0.85, 1.13] | 0.785 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 343 out of 3211 males with H8_MIDDLEADDH died.
Mortality risk
Mortality risk for people of age
years, who have H8_MIDDLEADDH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.124% | 0.176% |
| 5 | 0.686% | 1.216% |
| 10 | 1.732% | 2.881% |
| 15 | 3.336% | 5.368% |
| 20 | 5.743% | 8.851% |
Relationships between endpoints
↥Index endpoint: H8_MIDDLEADDH – Adhesive middle ear disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data