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Crystalline deposits in vitreous body

DOID EFO Endpoint Browser PheWeb

H7_VITRCRYSTAL

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H43.2
  • Cause of death: ICD-10 — H43.2

2 out of 7 registries used, show all original rules.

380

4. Check minimum number of events

None

380

5. Include endpoints

None

380

6. Filter based on genotype QC (FinnGen only)

334

Control definitions (FinnGen only)

Control exclude
H7_VITREOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H43
Name in latin
Depositiones crystallinae corporis vitrei

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1754 700 1049
Only index persons 1640 667 973
Unadjusted period prevalence (%)
Whole population 0.03 0.02 0.03
Only index persons 0.03 0.02 0.04
Median age at first event (years)
Whole population 71.12 69.89 71.95
Only index persons 70.79 69.70 71.54

-FinnGen-

Key figures

All Female Male
Number of individuals 334 131 203
Unadjusted period prevalence (%) 0.07 0.05 0.09
Median age at first event (years) 68.95 65.78 70.99

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
347
Matched controls
3470
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H43.2
ICD-10 Finland
Crystalline deposits in vitreous body
+∞
307.7
347
*
H43.8
ICD-10 Finland
Other disorders of vitreous body
22.1
72.4
56
30
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
13.9
44.4
43
35
H43.3
ICD-10 Finland
Other vitreous opacities
90.4
43.1
47
6
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.6
39.0
127
386
WX140
NOMESCO Finland
Parabulbar anesthesy
6.1
27.8
53
100
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.7
18.1
67
213
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.7
17.8
65
205
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.5
15.9
183
1066
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.3
15.5
43
111
H25.0
ICD-10 Finland
Senile incipient cataract
3.8
14.3
48
142
H26.4
ICD-10 Finland
After-cataract
3.3
14.3
62
217
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.5
14.0
126
647
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
4.3
12.7
34
85
H43.1
ICD-10 Finland
Vitreous haemorrhage
72.6
12.7
14
*
103
Kela drug reimbursment
Diabetes, insulin-treated
2.3
12.4
137
762
H25.8
ICD-10 Finland
Other senile cataract
2.8
11.9
71
296
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.1
11.1
51
184
A10AB04
ATC
insulin lispro; parenteral
5.7
11.0
21
39
A10AB01
ATC
insulin (human); parenteral
5.0
10.9
24
51
A10AE04
ATC
insulin glargine; parenteral
2.8
10.1
57
230
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
8.5
10.0
21
26
A10AA02, ,
ATC
4.6
10.0
24
55
M10
ICD-10 Finland
Gout
3.9
9.9
30
82
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.1
9.9
153
955
H25.1
ICD-10 Finland
Senile nuclear cataract
2.1
9.8
147
906
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
4.8
9.7
22
48
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
9.2
80
395
T89
ICPC
Diabetes insulin dependent
4.2
9.2
25
63
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.7
9.2
19
23
SPAT1262
SPAT
Handing over of treatment supplies
2.3
9.1
82
411
A10AA01, ,
ATC
7.2
8.7
20
29
T90
ICPC
Diabetes non-insulin dependent
2.0
8.3
116
689
H36.00
ICD-10 Finland
Diabetic background retinopathy
8.8
7.9
16
19
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
7.0
7.7
18
27
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.2
7.5
20
50
XCK10
NOMESCO Finland
Photography of fundus of eye
2.5
7.4
47
201
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.9
7.2
21
56
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
30.7
7.2
9
*
H3600, E103,
ICD-10 Finland
20.5
7.2
10
5
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
4.4
7.1
18
43
CKC12
NOMESCO Finland
Photocoagulation of retina
3.9
6.9
20
53
H52.1
ICD-10 Finland
Myopia
4.4
6.8
17
40
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
2.7
6.5
35
137
J01DB01
ATC
cefalexin; oral
2.0
6.3
281
2352
A10AE05
ATC
insulin detemir; parenteral
2.9
6.1
29
106

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
171
1129
2.01
9.29
4.3
3.5
79.57
57.91
mg/l
0.25
110
743
174
1162
2.00
9.09
5.5
4.2
9.75
9.58
mg/mmol
0.02
111
733
172
1154
1.97
8.77
4.4
3.4
6.80
7.52
mmol/l
1.49
140
950
214
1632
1.81
6.58
6.4
4.3
20.83
0.98
estimate
0.46
48
312
137
919
1.81
6.46
5.8
4.3
0.00
0.01
estimate
0.50
47
307
210
1608
1.77
6.21
6.3
4.3
0.27
4.75
estimate
0.46
55
342
179
1313
1.75
6.12
2.8
2.4
76.06
76.50
nmol/l
0.07
166
1160
208
1593
1.76
6.10
6.4
4.3
0.00
0.00
estimate
-0.00
52
336
181
1338
1.74
5.97
6.1
4.3
28.25
60.04
ng/l
0.76
150
1045
148
1038
1.74
5.86
2.2
2.2
137.88
236.17
u/l
2.49
143
981
111
716
1.81
5.86
2.2
1.8
463.09
19932274.80
pmol/l
0.50
86
587
141
979
1.74
5.76
5.0
3.6
—
—
—
0
0
277
2330
1.94
5.76
9.6
9.2
83.24
82.32
u/l
0.09
263
2192
300
2602
2.13
5.60
6.8
5.1
1.99
2.01
mu/l
0.11
278
2336
146
1031
1.72
5.57
4.9
4.5
—
—
—
0
0
164
1202
1.69
5.41
5.2
4.1
—
0.80
—
0
5
143
1019
1.69
5.19
3.1
2.7
64.13
66.53
u/l
0.12
138
941
54
285
2.06
5.15
3.5
2.2
0.00
0.00
estimate
—
7
58
250
2074
1.73
4.99
7.1
5.0
—
2.23
—
0
7
170
1281
1.64
4.89
5.3
3.9
6.23
6.21
ph
0.09
90
709
95
615
1.75
4.83
1.5
1.2
0.66
1.45
u/ml
1.19
25
158
255
2142
1.72
4.69
5.2
4.0
15.14
15.01
pmol/l
0.33
234
1916
316
2844
2.24
4.59
24.9
17.3
—
—
—
0
0
55
306
1.95
4.52
3.2
3.2
64.80
66.37
g/l
0.65
50
284
123
869
1.64
4.48
3.9
3.0
376.69
358.01
umol/l
1.05
103
756
46
241
2.05
4.47
5.6
3.6
7.42
7.42
ph
0.20
38
202
208
1670
1.61
4.46
8.4
7.6
1.21
1.21
mmol/l
0.15
178
1438
93
612
1.71
4.43
1.9
1.8
1122.79
1190.37
nmol/l
0.31
68
465
36
172
2.22
4.41
4.4
3.3
25.37
24.79
mmol/l
0.61
36
166
160
1209
1.60
4.41
6.4
4.3
4.57
0.04
estimate
0.79
44
284
24
95
2.64
4.40
1.6
1.4
254.04
275.81
ug/g
0.24
16
56
312
2805
2.11
4.37
7.5
6.4
2.41
2.56
mmol/l
2.06
286
2560
14
42
3.43
4.09
5.1
2.1
-0.26
0.93
mmol/l
0.38
14
42
46
251
1.96
4.00
3.3
2.9
—
—
—
0
0
15
48
3.22
3.98
3.3
2.9
4.05
4.08
mmol/l
0.11
15
48
15
48
3.22
3.98
3.3
2.9
103.80
105.54
mmol/l
0.61
15
48
88
586
1.67
3.97
2.9
3.3
0.82
0.82
mmol/l
0.28
83
559
320
2927
2.20
3.91
15.6
13.6
24.06
25.13
u/l
0.81
313
2832
14
38
3.79
3.84
4.1
2.8
—
—
—
0
0
18
67
2.78
3.72
3.8
4.3
—
—
—
0
0
301
2708
1.84
3.69
10.3
7.2
43.36
40.20
mmol/mol
4.69
280
2505
186
1495
1.53
3.68
4.8
5.4
34.72
35.12
g/l
0.43
172
1408
308
2796
1.90
3.59
25.9
19.2
30.82
26.66
mg/l
1.08
270
2362
324
2995
2.23
3.56
37.5
29.1
242.44
240.98
e9/l
0.14
319
2933
324
2995
2.23
3.56
37.6
29.1
7.10
6.89
e9/l
0.85
319
2919
324
2995
2.23
3.56
37.5
29.0
4.37
4.43
e12/l
1.14
318
2918
22
94
2.43
3.49
7.4
5.2
—
—
—
0
0
75
495
1.66
3.47
2.4
2.0
—
—
—
0
0
14
47
3.06
3.45
3.5
2.9
1.20
1.19
mmol/l
0.11
14
47
304
2757
1.83
3.44
6.8
5.7
6.41
6.07
mmol/l
3.71
275
2496
154
1202
1.51
3.42
4.0
3.4
1206.18
1391.37
ng/l
0.40
136
1057
302
2735
1.80
3.41
6.6
5.5
1.43
1.43
mmol/l
0.10
274
2479
303
2747
1.81
3.41
6.5
5.6
4.32
4.44
mmol/l
1.28
276
2515
293
2637
1.71
3.31
5.4
4.6
1.33
1.27
mmol/l
0.81
260
2368
60
378
1.71
3.29
2.7
1.6
—
—
—
0
0
83
573
1.59
3.19
1.9
1.5
2.34
2.73
g/l
1.06
54
334
98
707
1.54
3.10
5.8
4.6
1.02
1.02
kg/l
0.49
61
483
199
1660
1.47
3.05
19.5
16.0
1.25
1.30
inr
0.73
178
1388
37
208
1.87
2.97
1.4
1.2
—
—
—
0
0
215
1826
1.47
2.97
3.9
3.6
62.40
54.16
u/l
0.52
200
1705
206
1736
1.46
2.95
7.2
7.4
10.31
12.08
umol/l
2.75
198
1659
28
145
2.01
2.84
1.6
1.3
—
—
—
0
0
133
1038
1.46
2.83
2.1
1.8
23.97
20.09
nmol/l
1.90
112
854
5
6
8.43
2.76
2.0
1.7
35.00
36.67
%
—
5
6
29
154
1.96
2.75
2.6
1.9
—
—
—
0
0
48
299
1.70
2.75
2.8
2.1
375.14
392.63
nmol/l
0.22
43
279
25
128
2.03
2.63
2.7
3.8
297.17
213.11
mg/l
0.53
12
53
150
1211
1.42
2.61
2.1
2.0
1.38
1.29
mmol/l
0.71
117
989
13
51
2.61
2.47
3.5
2.8
0.91
1.41
g/24h
—
7
32
8
23
3.53
2.28
2.0
1.3
—
—
—
0
0
35
211
1.73
2.27
3.2
2.7
0.75
0.63
%
1.82
35
211
137
1113
1.38
2.22
5.2
3.6
459.78
120.40
e6/l
0.35
114
857
30
174
1.79
2.21
6.5
3.8
—
—
—
0
0
61
428
1.52
2.16
1.3
1.3
—
—
—
0
0
165
1390
1.36
2.10
6.4
6.0
2.58
2.95
ug/l
0.26
146
1231
35
217
1.68
2.07
3.2
2.7
1.30
1.17
%
0.41
35
217
63
450
1.49
2.05
1.3
1.3
16.39
8.50
u/ml
0.21
23
166
6
15
4.05
2.04
1.2
2.5
35.72
41.43
g/l
—
6
15
171
1453
1.35
2.04
3.0
2.9
—
—
estimate
—
0
0
36
226
1.66
2.03
3.4
4.3
—
—
—
0
0
27
156
1.79
2.03
2.6
2.4
—
—
—
0
0
39
251
1.62
2.00
3.5
4.1
1.23
1.22
mmol/l
0.16
33
219
169
1439
1.34
1.96
5.5
6.5
25.88
26.09
%
0.09
160
1359
11
45
2.49
1.95
1.1
1.1
—
—
—
0
0
28
166
1.75
1.94
1.3
1.2
—
—
—
0
0
173
1480
1.34
1.94
2.8
2.2
98.27
95.34
pmol/l
0.33
91
795
17
85
2.05
1.93
6.7
10.8
—
—
—
0
0
177
1520
1.34
1.93
8.0
6.9
1.21
1.21
mmol/l
0.09
161
1383
199
1740
1.34
1.91
8.3
10.2
4.51
4.29
e9/l
0.53
175
1524
139
1155
1.34
1.88
2.2
3.8
2.34
2.35
mmol/l
0.18
119
1041
146
1225
1.33
1.84
6.0
4.3
83.58
98.53
e6/l
0.12
116
886
53
374
1.49
1.84
4.2
3.8
1.54
1.80
mmol/l
0.27
48
314
7
23
3.08
1.81
2.1
1.4
22.43
35.25
ng/l
—
7
23
51
359
1.49
1.79
2.0
2.9
64.52
68.73
e9/l
0.63
41
266
21
118
1.83
1.74
3.9
3.7
1.25
3.59
ratio
1.62
13
62
178
1545
1.31
1.74
5.6
6.0
0.04
0.04
e9/l
0.25
156
1324
165
1419
1.31
1.72
5.5
6.4
0.61
0.65
%
0.54
154
1327
74
565
1.39
1.70
2.9
2.6
2.39
2.25
g/l
1.30
62
524
179
1563
1.30
1.64
5.7
6.2
1.75
1.82
e9/l
0.50
161
1378
66
498
1.40
1.62
1.3
1.3
26.26
34.01
iu/ml
0.40
18
156
105
855
1.33
1.60
7.1
3.8
7.17
0.10
estimate
0.60
42
273
176
1538
1.29
1.59
5.6
6.0
0.62
0.61
e9/l
0.05
157
1315
46
326
1.47
1.58
3.9
3.1
4.33
4.30
kpa
0.06
46
315
46
327
1.47
1.55
5.2
4.3
7.38
7.35
ph
1.39
27
229
42
294
1.49
1.53
2.3
2.2
203.39
155.04
ug/g
0.21
31
243
164
1425
1.29
1.53
5.8
6.4
9.05
9.04
%
0.01
152
1332
38
261
1.51
1.51
3.1
4.8
0.00
0.20
%
—
7
75
126
1062
1.29
1.48
2.6
2.5
—
—
—
0
0
163
1421
1.28
1.46
5.7
6.3
57.99
58.44
%
0.17
158
1348
53
393
1.41
1.44
4.4
3.7
7.39
7.38
ph
0.08
40
226
163
1426
1.27
1.41
5.5
6.3
2.75
2.88
%
0.29
151
1330
16
89
1.84
1.39
2.8
2.5
231.72
86.37
ug/min
—
9
45
39
276
1.47
1.36
2.8
4.3
0.50
1.04
%
—
8
102
51
382
1.39
1.32
4.4
3.8
5.65
5.74
kpa
0.29
51
371
9
43
2.12
1.31
2.6
2.6
—
—
—
0
0
6
24
2.53
1.31
1.0
1.1
—
—
—
0
0
6
24
2.53
1.31
1.0
1.1
—
—
—
0
0
105
877
1.28
1.30
3.2
2.2
2.77
3.00
mg/l
0.61
94
762
20
122
1.68
1.30
1.3
1.1
—
—
—
0
0
178
1587
1.25
1.27
5.8
6.3
0.19
0.20
e9/l
0.19
162
1381
12
63
1.94
1.24
1.2
1.4
0.90
0.79
nmol/l
—
6
54
8
37
2.19
1.22
1.6
1.2
—
—
—
0
0
5
19
2.65
1.22
1.4
1.3
—
—
—
0
0
36
257
1.45
1.22
4.7
2.8
5.89
6.07
ph
0.59
22
181
112
953
1.26
1.18
4.9
3.5
0.27
0.58
e6/l
1.39
92
701
122
1049
1.25
1.18
5.5
6.2
—
—
—
0
0
67
534
1.32
1.18
3.0
2.6
20.50
21.94
%
0.58
57
500
35
254
1.42
1.10
2.9
4.4
0.00
0.15
%
—
5
80
5
21
2.40
1.09
2.0
2.0
38.00
33.83
%
—
5
21
75
614
1.28
1.08
3.1
2.6
11.52
12.51
umol/l
0.66
66
570
35
255
1.41
1.08
2.9
4.4
0.50
0.50
%
—
8
89
49
379
1.34
1.06
4.0
3.4
4.73
4.94
e9/l
0.10
40
325
50
389
1.33
1.04
1.6
1.5
—
—
—
0
0
5
23
2.19
0.98
1.2
2.2
—
—
—
0
0
5
23
2.19
0.98
1.2
2.0
—
—
—
0
0
7
36
1.96
0.97
1.1
2.6
—
—
—
0
0
115
1006
1.21
0.92
5.1
4.6
7.40
7.40
ph
0.00
84
727
6
29
2.09
0.89
1.0
1.1
—
—
—
0
0
103
896
1.21
0.87
4.9
3.4
—
0.00
estimate
—
0
5
17
112
1.54
0.86
1.4
1.2
—
—
—
0
0
8
140
0.56
0.85
1.3
1.5
—
—
—
0
0
8
45
1.80
0.85
1.5
1.6
—
—
—
0
0
8
45
1.80
0.85
1.5
1.6
—
—
—
0
0
8
45
1.80
0.85
1.8
1.9
—
—
—
0
0
8
45
1.80
0.85
1.5
1.6
—
—
—
0
0
8
45
1.80
0.85
1.5
1.6
—
—
—
0
0
38
294
1.33
0.84
1.4
1.4
—
—
—
0
0
54
440
1.27
0.83
5.4
7.2
1.26
1.00
mmol/l
0.29
47
370
6
32
1.89
0.82
1.2
1.0
—
—
—
0
0
6
32
1.89
0.82
1.2
1.6
—
—
—
0
0
55
451
1.26
0.80
2.0
2.7
1.67
1.81
%
0.71
45
408
74
628
1.23
0.80
5.4
5.1
—
—
—
0
0
0
24
0.00
0.79
0.0
3.3
—
0.79
—
0
24
24
175
1.40
0.77
2.3
2.9
—
—
—
0
0
79
678
1.21
0.77
1.5
1.8
1.57
1.52
mg/l
0.03
58
548
49
399
1.27
0.76
3.2
4.7
18.81
42.49
ug/l
0.44
41
338
14
92
1.54
0.73
1.2
1.8
—
—
—
0
0
10
60
1.69
0.73
4.0
3.6
14.44
11.14
pmol/l
—
10
60
12
76
1.60
0.72
1.8
1.2
—
—
—
0
0
54
448
1.24
0.72
5.5
7.2
7.43
7.41
ph
1.24
30
258
146
1330
1.17
0.72
4.0
3.0
131.72
143.37
ug/l
0.34
132
1226
5
27
1.86
0.68
2.0
1.9
2020.20
1164.32
e6/l
—
5
22
5
27
1.86
0.68
1.0
1.2
—
—
—
0
0
6
104
0.57
0.63
5.0
6.5
1.10
1.42
mmol/l
—
6
92
11
71
1.57
0.63
1.2
1.4
—
—
—
0
0
5
30
1.68
0.61
1.0
1.5
—
—
—
0
0
8
52
1.55
0.60
1.1
1.6
—
—
—
0
0
88
781
1.17
0.60
1.4
1.4
—
—
—
0
0
19
140
1.38
0.59
1.7
2.1
222.58
322.14
ug/l
0.67
19
132
30
238
1.29
0.59
6.9
3.9
—
—
—
0
0
6
35
1.73
0.58
1.0
1.4
0.52
0.57
nmol/l
—
6
30
6
35
1.73
0.58
4.7
3.2
507.83
895.51
mg
—
6
35
8
54
1.49
0.57
1.8
1.6
30.90
32.59
g/l
—
8
48
103
929
1.15
0.57
4.6
3.7
—
—
—
0
0
34
276
1.26
0.56
1.4
1.6
—
—
—
0
0
43
359
1.23
0.56
1.5
1.3
—
—
—
0
0
6
38
1.59
0.54
10.7
1.6
—
—
—
0
0
14
192
0.72
0.53
1.3
1.4
—
—
—
0
0
40
334
1.22
0.53
1.3
1.5
—
—
—
0
0
6
40
1.51
0.52
2.0
1.6
—
—
—
0
0
7
47
1.50
0.48
9.4
1.4
—
—
—
0
0
7
47
1.50
0.48
9.0
1.4
—
—
—
0
0
7
47
1.50
0.48
1.0
1.0
—
—
—
0
0
7
47
1.50
0.48
9.3
1.4
—
—
—
0
0
7
48
1.47
0.47
10.0
1.4
—
—
—
0
0
7
48
1.47
0.47
2.1
3.5
—
—
—
0
0
10
69
1.46
0.44
1.3
1.3
—
—
—
0
0
7
51
1.38
0.44
1.7
1.9
33.29
32.59
pg
—
7
51
5
31
1.62
0.43
1.0
1.6
—
—
—
0
0
23
185
1.26
0.43
2.5
2.4
29.26
19.09
au/ml
—
5
15
29
240
1.23
0.43
5.8
8.9
24.75
24.41
mmol/l
0.38
29
234
8
57
1.41
0.42
1.6
1.5
148.34
266.16
pmol/l
—
8
57
5
32
1.57
0.42
1.0
1.2
—
—
—
0
0
5
33
1.52
0.41
10.0
1.4
—
—
—
0
0
12
88
1.38
0.40
1.2
1.1
—
—
—
0
0
77
702
1.12
0.37
1.9
3.2
2.46
2.45
mmol/l
0.27
65
637
18
144
1.26
0.36
1.2
1.3
—
—
—
0
0
231
2233
1.10
0.35
30.3
25.4
332.61
331.56
g/l
1.15
231
2220
141
1333
1.10
0.34
16.3
12.5
0.00
0.00
e9/l
0.31
117
1099
6
44
1.37
0.34
9.2
1.5
—
—
—
0
0
6
44
1.37
0.34
1.2
2.0
82.88
89.08
%
—
6
44
11
82
1.35
0.34
1.7
2.3
14.17
12.97
mg/l
0.41
11
76
6
45
1.34
0.34
1.8
1.5
6.78
6.08
mmol/l
—
6
40
10
74
1.36
0.32
2.3
1.9
33.90
43.64
nmol/l
—
10
67
15
119
1.27
0.32
1.1
1.7
—
—
—
0
0
41
368
1.13
0.26
1.2
1.7
—
—
—
0
0
5
73
0.68
0.26
5.4
7.2
11.20
11.37
mmol/l
—
5
67
5
73
0.68
0.26
5.4
7.2
105.60
105.01
mmol/l
—
5
67
99
933
1.09
0.26
7.6
6.6
—
—
—
0
0
9
72
1.26
0.26
1.0
1.1
—
—
—
0
0
9
75
1.21
0.25
1.0
1.1
—
—
—
0
0
10
78
1.29
0.24
1.2
4.1
21.00
34.60
umol/l
—
5
72
19
221
0.85
0.23
9.5
9.0
14.95
15.69
%
0.84
19
214
5
40
1.25
0.22
1.6
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.7
—
—
—
0
0
0
10
0.00
0.21
0.0
4.6
—
56.80
—
0
10
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
6
50
1.20
0.20
1.0
1.1
—
—
—
0
0
12
142
0.84
0.18
1.2
1.2
45.63
138.81
u/ml
—
6
49
5
67
0.74
0.17
1.0
1.2
—
—
—
0
0
5
69
0.72
0.17
3.6
2.5
57.80
58.84
%
—
5
69
60
567
1.07
0.15
5.2
3.4
1.50
1.76
e6/l
0.19
39
295
35
323
1.09
0.15
6.9
8.4
—
—
—
0
0
6
58
1.04
0.08
1.0
1.1
—
—
—
0
0
40
419
0.95
0.08
1.2
1.3
—
—
—
0
0
5
65
0.77
0.08
1.6
1.5
—
—
—
0
0
7
68
1.03
0.08
1.1
1.3
—
—
—
0
0
12
108
1.12
0.07
1.0
1.1
—
—
—
0
0
123
1207
1.03
0.07
2.6
2.2
—
—
—
0
0
11
121
0.91
0.06
1.6
1.5
0.43
0.33
mg/l
—
5
53
40
386
1.04
0.05
1.5
1.3
200.00
471.34
titre
—
10
97
213
2113
1.02
0.04
5.6
4.7
—
0.40
—
0
5
69
676
1.03
0.04
6.1
4.1
573.60
330.41
ng/l
0.22
54
570
82
806
1.02
0.04
3.1
3.5
0.81
0.80
ug/l
0.05
58
561
26
250
1.04
0.03
1.7
1.6
—
—
—
0
0
10
101
0.99
0.00
1.3
1.3
—
3.03
—
0
9
11
115
0.96
0.00
1.4
2.2
20.73
21.26
s
0.25
11
108
32
315
1.02
0.00
3.2
2.5
4.89
8.08
ug/l
1.02
25
278
29
295
0.98
0.00
1.2
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
67
0.89
-0.00
1.3
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
-0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.2
0.85
0.87
g/l
—
5
52
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.0
1.2
1.57
1.57
g/l
—
5
50
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.3
—
2.11
—
0
9
15
150
1.00
-0.00
1.3
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
37.50
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_VITRCRYSTAL and mortality.

Females

Parameter HR [95% CI] p-value
H7_VITRCRYSTAL 0.983 [0.8, 1.21] 0.868
Birth year 0.996 [0.99, 1.0] 0.342

During the follow-up period (1.1.1998 — 31.12.2019), 133 out of 603 females with H7_VITRCRYSTAL died.

Males

Parameter HR [95% CI] p-value
H7_VITRCRYSTAL 0.981 [0.8, 1.2] 0.852
Birth year 0.989 [0.98, 1.0] 0.021

During the follow-up period (1.1.1998 — 31.12.2019), 251 out of 834 males with H7_VITRCRYSTAL died.

Mortality risk

Mortality risk for people of age

years, who have H7_VITRCRYSTAL.

N-year risk Females Males
1 0.063% 0.173%
5 0.566% 1.147%
10 1.412% 2.925%
15 2.787% 5.421%
20 4.935% 9.54%

Relationships between endpoints

↥

Index endpoint: H7_VITRCRYSTAL – Crystalline deposits in vitreous body

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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