retinal detachment: An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
951 |
4. Check minimum number of eventsNone |
951 |
5. Include endpointsNone |
951 |
6. Filter based on genotype QC (FinnGen only) |
871 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H33
- Name in latin
- Retinoschisis et cystae retinales
Similar endpoints
↥List of similar endpoints to
Retinoschisis and retinal cysts
based on the number of shared cases.
Similar with more cases:
- Retinal detachments and breaks
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5538 | 2706 | 2804 |
| Only index persons | 5192 | 2588 | 2604 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.10 | 0.10 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 62.82 | 63.54 | 62.17 |
| Only index persons | 62.55 | 63.27 | 61.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 871 | 418 | 453 |
| Unadjusted period prevalence (%) | 0.18 | 0.15 | 0.21 |
| Median age at first event (years) | 63.86 | 62.25 | 65.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 894
- Matched controls
- 8940
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H33.1
ICD-10 Finland
Retinoschisis and retinal cysts
+∞
307.7
858
*
CKC12
NOMESCO Finland
Photocoagulation of retina
532.6
307.7
334
10
H33.0
ICD-10 Finland
Retinal detachment with retinal break
2051.6
173.8
163
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
60.1
128.3
72
13
H33.3
ICD-10 Finland
Retinal breaks without detachment
1303.3
119.7
114
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
7.5
115.7
188
305
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
48.5
100.7
59
13
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.5
94.8
133
181
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.1
88.1
173
336
CKC10
NOMESCO Finland
Local photocoagulation of retina
471.9
87.7
86
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
33.0
77.2
50
16
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
16.2
74.9
65
43
H43.8
ICD-10 Finland
Other disorders of vitreous body
4.7
69.6
187
473
WX140
NOMESCO Finland
Parabulbar anesthesy
10.6
67.8
77
79
H43.1
ICD-10 Finland
Vitreous haemorrhage
17.0
62.9
53
33
CKD40
NOMESCO Finland
Endophotocoagulation of retina
+∞
51.6
49
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
87.0
51.6
57
7
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
172.6
47.3
49
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.4
46.7
205
720
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
38.8
37
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
57.7
37.7
44
8
H26.4
ICD-10 Finland
After-cataract
3.3
33.5
146
504
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
32.6
210
900
H35.4
ICD-10 Finland
Peripheral retinal degeneration
117.7
31.9
34
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.4
30.1
121
396
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
29.6
459
2884
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.3
29.6
369
2124
Q14.10
ICD-10 Finland
Congenital retinoschis
+∞
29.3
28
*
XCK10
NOMESCO Finland
Photography of fundus of eye
3.2
26.4
112
378
H33.5
ICD-10 Finland
Other retinal detachments
38.0
26.3
33
9
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
139.0
25.7
27
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
92.8
24.8
27
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.1
24.1
364
2214
3611A
ICD-9 Finland
Retinal detachments and defects, Retinoschisis and retinal cysts
+∞
23.0
22
*
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
23.0
22
*
XCH00
NOMESCO Finland
Eye pressure measurement
3.9
22.0
66
177
37603
ICD-8 Finland
Detachment of retina, Retinoschisis
+∞
22.0
21
*
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
75.2
19.8
22
*
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
47.1
19.3
23
5
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
18.8
18
*
XCK00
NOMESCO Finland
Perimetry
3.2
17.8
72
235
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
68.0
17.8
20
*
H53.1
ICD-10 Finland
Subjective visual disturbances
2.9
16.7
81
294
H33.2
ICD-10 Finland
Serous retinal detachment
+∞
16.7
16
*
CKC30
NOMESCO Finland
Cryopexy of detached retina
+∞
16.7
16
*
S01ED01
ATC
timolol; ophthalmic
4.0
16.2
47
123
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
18.9
16.1
24
13
S01ED51
ATC
timolol, combinations; ophthalmic
2.7
15.9
90
355
H3600, E113,
ICD-10 Finland
+∞
15.7
15
*
H52.1
ICD-10 Finland
Myopia
4.1
14.7
40
100
H35.36
ICD-10 Finland
Macular cyst
+∞
14.6
14
*
CKC60
NOMESCO Finland
Local buckling of sclera using implant
+∞
14.6
14
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
152.4
14.5
15
*
H25.1
ICD-10 Finland
Senile nuclear cataract
1.8
13.6
288
1884
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
142.1
13.5
14
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.4
12.6
45
136
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
+∞
12.5
12
*
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
12.5
12
*
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
12.5
12
*
H35.37
ICD-10 Finland
Macular holes
131.8
12.5
13
*
H26.2
ICD-10 Finland
Complicated cataract
9.5
12.0
24
26
H3601, E113,
ICD-10 Finland
+∞
11.5
11
*
3745
FHL
Hard membrane girding, cerclage with coagulation
+∞
11.5
11
*
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
+∞
11.5
11
*
H25.0
ICD-10 Finland
Senile incipient cataract
2.5
11.1
73
310
CKC15
NOMESCO Finland
Panretinal photocoagulation
43.9
10.9
13
*
S01BC03
ATC
diclofenac; ophthalmic
4.5
10.8
26
59
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
111.3
10.4
11
*
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
+∞
10.4
10
*
S01EA05
ATC
brimonidine; ophthalmic
3.5
9.7
33
97
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
11.5
9.6
17
15
H26.02
ICD-10 Finland
Presenil cataract
3.6
9.6
31
88
ZXA10
NOMESCO Finland
Bilateral
1.8
9.5
168
1029
3744
FHL
Pericardial identification surgery with coagulation (includes epi- and intrascleral indications and eg Lincoff catheter)
+∞
9.4
9
*
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
9.4
9
*
S01EC04
ATC
brinzolamide; ophthalmic
2.8
9.4
47
174
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
9.4
111
598
A98
ICPC
Health maint/preventive medicine
2.7
9.2
853
7924
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.9
9.0
132
763
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
8.6
369
2809
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
3.3
8.6
32
100
S01EE01
ATC
latanoprost; ophthalmic
2.2
8.3
67
311
UDC00
NOMESCO Finland
Ear microscopy
2.2
8.3
74
359
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.7
8.2
190
1251
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
3.5
8.1
28
83
SPAT1263
SPAT
Sampling
1.5
7.9
349
2664
H36.01
ICD-10 Finland
Diabetic maculopathy
45.4
7.7
9
*
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
6.0
7.7
20
34
H40.0
ICD-10 Finland
Glaucoma suspect
2.1
7.7
78
398
114
Kela drug reimbursment
Glaucoma
2.0
7.6
87
463
A10AA02, ,
ATC
3.9
7.6
22
58
SPAT1312
SPAT
General health counselling
1.5
7.3
253
1826
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
7.3
7
*
S01BC05
ATC
ketorolac; ophthalmic
2.6
6.8
39
155
H20.1
ICD-10 Finland
Chronic iridocyclitis
8.3
6.8
14
17
A10AB01
ATC
insulin (human); parenteral
3.7
6.8
21
58
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.9
6.8
90
504
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
40.4
6.8
8
*
S01EC01
ATC
acetazolamide; systemic
3.8
6.7
20
54
H25.8
ICD-10 Finland
Other senile cataract
1.8
6.6
103
607
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.3
6.6
49
221
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
18.2
6.3
9
5
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
2.5
6.3
37
150
37600
ICD-8 Finland
Detachment of retina, Primaria
+∞
6.3
6
*
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
6.3
6
*
H3603, E113,
ICD-10 Finland
+∞
6.3
6
*
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
+∞
6.3
6
*
SPAT1043
SPAT
Audiometry
1.8
6.1
102
612
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
6.0
337
2656
S01EC03
ATC
dorzolamide; ophthalmic
3.9
6.0
17
44
DFF00
NOMESCO Finland
Pure tone audiometry
1.7
6.0
104
631
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
795
7045
2.16
12.01
6.1
5.3
2.00
2.01
mu/l
0.05
719
6446
821
7442
2.26
10.49
5.9
5.3
1.44
1.45
mmol/l
0.33
745
6836
834
7621
2.41
10.25
6.9
6.2
2.52
2.63
mmol/l
3.35
761
7018
819
7478
2.13
9.26
6.0
5.4
4.43
4.54
mmol/l
2.34
748
6927
816
7450
2.09
9.07
6.1
5.6
5.95
6.02
mmol/l
1.10
739
6787
682
5924
1.64
8.83
4.9
4.3
15.11
14.97
pmol/l
0.79
616
5394
858
8012
2.76
8.79
27.1
24.1
84.94
80.67
umol/l
1.83
849
7915
863
8089
2.93
8.64
30.3
27.3
91.59
91.65
fl
0.16
851
7993
851
7925
2.53
8.61
15.0
13.0
26.09
25.65
u/l
0.32
823
7689
863
8091
2.92
8.60
30.7
28.0
39.98
40.04
%
0.12
851
7989
863
8091
2.92
8.60
30.3
27.4
4.44
4.44
e12/l
0.02
838
7893
863
8091
2.92
8.60
30.5
27.4
242.80
244.41
e9/l
0.31
840
7918
863
8092
2.92
8.58
30.6
27.6
134.28
134.05
g/l
0.17
852
7997
678
5911
1.61
8.32
5.3
4.5
13.77
13.42
mm/h
0.22
635
5491
816
7499
2.01
8.14
19.6
18.1
23.54
26.61
mg/l
1.91
689
6310
844
7865
2.31
7.94
24.1
22.0
3.99
4.00
mmol/l
0.07
828
7710
842
7849
2.25
7.74
23.9
21.8
139.78
139.66
mmol/l
0.74
825
7705
796
7306
1.82
7.25
7.5
6.8
39.47
39.64
mmol/mol
0.28
727
6784
778
7150
1.68
6.33
5.0
4.5
1.27
1.29
mmol/l
0.34
697
6519
791
7327
1.69
5.91
19.9
17.7
74.44
76.67
ml/min/173m2
2.53
730
6849
692
6229
1.49
5.77
10.0
8.6
80.90
80.27
u/l
0.09
654
5915
433
3605
1.39
5.51
2.5
2.4
77.17
79.18
nmol/l
0.81
387
3207
485
4133
1.38
5.26
19.7
16.8
1.31
1.29
inr
0.31
416
3464
329
2647
1.38
5.02
1.7
1.7
20.10
19.97
nmol/l
0.06
277
2240
181
1315
1.47
4.86
2.7
2.6
21.72
22.39
%
0.31
169
1222
202
1503
1.44
4.78
2.7
2.6
12.29
12.53
umol/l
0.21
186
1398
189
1400
1.44
4.57
2.7
2.6
2.29
2.28
g/l
0.16
171
1295
452
3883
1.33
4.30
6.2
5.2
35.27
35.15
g/l
0.18
414
3638
504
4405
1.33
4.23
8.2
7.5
1.21
1.21
mmol/l
0.38
428
3805
494
4308
1.33
4.19
4.5
4.1
0.00
0.35
estimate
0.51
113
870
420
3580
1.33
4.18
3.4
3.0
140.20
148.60
ug/l
0.34
392
3306
380
3201
1.33
4.08
6.4
5.9
3.38
2.73
ug/l
0.37
337
2877
331
2734
1.33
4.07
2.3
2.2
215.81
237.36
u/l
0.14
315
2592
298
2425
1.34
4.05
4.4
4.2
0.00
0.01
estimate
0.96
110
838
345
2888
1.32
3.80
3.4
3.3
1337.14
1380.60
ng/l
0.08
293
2514
525
4654
1.31
3.79
10.1
9.7
4.07
4.19
e9/l
0.48
449
4029
488
4288
1.30
3.74
4.5
4.1
0.00
3.60
estimate
0.80
124
937
449
3907
1.30
3.68
2.3
2.2
100.71
95.18
pmol/l
1.42
231
2062
556
4982
1.31
3.63
5.3
5.4
6.58
6.73
mmol/l
1.37
525
4781
481
4232
1.30
3.59
4.4
4.1
0.00
0.00
estimate
0.50
121
911
101
698
1.50
3.46
6.1
3.7
1.22
1.23
mmol/l
0.34
93
608
504
4487
1.28
3.32
7.3
6.9
11.85
11.88
umol/l
0.02
476
4301
269
2216
1.31
3.23
4.3
3.6
0.01
0.04
estimate
0.42
101
714
270
2230
1.30
3.17
3.3
2.9
355.58
351.04
umol/l
0.32
234
1956
317
2679
1.28
3.11
2.7
2.6
57.46
91.36
u/l
0.59
291
2482
139
1042
1.40
3.11
6.0
5.0
31.83
32.49
%
0.28
96
674
352
3022
1.27
3.03
4.6
4.1
9.99
7.69
mg/mmol
0.43
212
1895
382
3315
1.27
3.00
2.0
1.9
1.31
1.33
mmol/l
0.24
291
2750
207
1667
1.31
2.90
1.3
1.3
1.16
1.72
u/ml
0.44
56
450
349
3013
1.26
2.82
3.8
3.7
2.34
2.35
mmol/l
0.99
314
2724
19
86
2.24
2.65
1.2
1.3
—
—
—
0
0
365
3191
1.24
2.58
4.6
4.1
5.08
0.03
estimate
0.50
99
753
60
401
1.53
2.45
4.6
3.7
4.39
4.45
pmol/l
0.19
53
354
577
5317
1.24
2.44
5.3
5.0
4.17
2117.53
e6/l
—
6
81
267
2269
1.25
2.40
2.6
2.3
2.89
2.91
mg/l
0.06
239
1933
383
3385
1.23
2.40
4.6
4.1
40.54
89.95
ng/l
1.11
302
2573
32
183
1.78
2.38
1.3
1.3
—
—
—
0
0
93
686
1.40
2.31
1.5
1.5
—
—
—
0
0
218
1817
1.26
2.31
1.8
1.8
64204944.23
15333767.02
pmol/l
0.34
176
1500
443
3989
1.22
2.28
7.0
6.8
1.21
1.21
mmol/l
0.68
411
3684
176
1434
1.28
2.24
1.4
1.3
28.49
36.27
iu/ml
0.23
40
457
5
9
5.58
2.21
1.0
1.3
—
—
—
0
0
426
3832
1.21
2.18
2.9
2.9
—
—
estimate
—
0
0
297
2577
1.23
2.18
5.3
4.8
22.34
21.27
%
0.67
156
1323
344
3035
1.22
2.14
3.8
3.3
7.32
7.54
mmol/l
0.38
286
2548
653
6136
1.24
2.13
24.1
22.6
13.70
13.77
%
0.74
642
6051
208
1743
1.25
2.10
1.7
1.7
1.06
1.36
mg/l
1.26
158
1389
5
10
5.02
2.07
1.0
1.2
—
—
—
0
0
542
5030
1.20
1.87
3.5
3.4
49.20
53.60
u/l
0.62
494
4704
114
920
1.27
1.59
4.0
3.5
—
—
—
0
0
182
1550
1.22
1.57
1.9
1.8
1174.89
1190.09
nmol/l
0.07
129
1165
25
154
1.64
1.51
1.3
1.3
13.78
8.26
u/l
0.87
18
115
29
186
1.58
1.50
2.0
1.8
5.22
3.80
iu/l
0.29
12
74
68
517
1.34
1.47
3.1
3.6
1.64
1.92
mmol/l
0.21
53
391
94
756
1.27
1.37
3.3
3.1
146.34
228.65
ng/l
2.22
86
703
6
23
2.62
1.37
1.7
1.3
111.00
103.71
%
—
6
17
5
17
2.95
1.36
1.0
1.2
—
—
—
0
0
8
34
2.36
1.29
1.0
1.3
—
—
—
0
0
97
790
1.26
1.28
2.5
2.5
5.81
7.01
ug/l
0.33
84
703
12
62
1.95
1.28
1.1
1.2
—
—
—
0
0
433
4023
1.15
1.27
2.7
2.6
—
—
—
0
0
9
44
2.06
1.27
1.4
1.4
5.40
6.59
u/l
—
9
34
130
1096
1.22
1.26
4.1
4.3
231.92
252.45
u/l
1.26
124
1035
35
248
1.43
1.18
1.7
1.6
39.06
14.35
u/ml
0.72
11
49
109
910
1.23
1.17
2.3
2.3
180.31
138.05
ug/g
0.58
86
740
8
39
2.06
1.15
1.0
1.2
—
—
—
0
0
5
20
2.51
1.15
1.0
1.2
—
—
—
0
0
5
20
2.51
1.15
1.0
1.1
—
—
—
0
0
5
20
2.51
1.15
1.0
2.0
103.72
108.30
nmol/24h
—
5
20
115
968
1.22
1.14
1.3
1.4
—
—
—
0
0
43
319
1.37
1.13
2.5
1.9
11.37
7.66
iu/ml
0.26
12
83
36
259
1.41
1.13
1.3
1.5
235.75
275.78
ug/g
0.66
17
160
24
159
1.52
1.13
1.6
1.4
—
—
—
0
0
178
1564
1.17
1.10
1.9
2.0
—
—
—
0
0
5
21
2.39
1.09
1.2
1.3
—
—
—
0
0
5
21
2.39
1.09
1.0
1.1
—
—
—
0
0
116
987
1.20
1.04
7.8
7.5
—
—
—
0
0
16
98
1.64
1.03
2.1
2.4
-0.10
0.34
mmol/l
0.24
16
93
5
22
2.28
1.03
1.0
1.2
—
—
—
0
0
7
34
2.07
1.03
1.1
1.3
—
—
—
0
0
137
1186
1.18
1.02
1.7
1.9
—
—
—
0
0
26
180
1.46
1.01
2.0
2.7
14.98
15.88
%
0.60
26
175
34
248
1.39
1.01
2.4
3.7
1.78
1.64
mg/l
0.28
26
225
9
48
1.88
1.00
1.7
3.1
—
—
—
0
0
114
973
1.20
1.00
3.1
2.8
9.38
8.44
umol/l
0.16
99
859
292
2679
1.13
0.99
3.1
3.4
29.26
33.02
u/l
2.26
275
2519
7
36
1.95
0.97
1.0
1.8
—
—
—
0
0
84
699
1.22
0.96
4.2
3.8
96.07
92.91
ng/l
0.12
70
610
158
1393
1.16
0.95
2.0
2.0
28.98
29.60
s
0.66
152
1356
39
296
1.33
0.92
1.2
1.2
0.14
1.52
u/ml
—
5
20
23
159
1.46
0.92
6.4
3.0
9.98
9.10
pmol/l
0.19
23
159
89
749
1.21
0.91
2.6
2.4
0.20
0.49
e6/l
1.42
84
712
16
102
1.58
0.91
1.4
1.5
42.91
65.35
%
1.40
11
65
8
42
1.91
0.88
1.3
1.2
143.63
164.16
pmol/l
—
8
42
31
229
1.37
0.87
1.6
2.5
4.06
3.69
g/l
0.53
31
220
59
478
1.25
0.87
1.2
1.2
258.55
202.41
u/ml
0.23
54
436
57
460
1.26
0.87
1.4
1.4
78.75
42.33
au/ml
—
8
35
6
30
2.01
0.87
1.3
1.3
—
—
—
0
0
16
104
1.55
0.85
1.6
1.4
—
—
—
0
0
188
1694
1.14
0.84
4.3
4.3
334.55
397.93
ng/l
0.12
157
1407
170
1522
1.14
0.84
3.2
3.5
0.83
0.82
mmol/l
0.69
162
1433
91
775
1.19
0.84
2.8
2.1
408.27
384.41
nmol/l
0.51
81
717
82
692
1.20
0.83
2.3
2.3
15.00
13.09
nmol/l
1.32
68
622
39
302
1.30
0.82
2.0
1.7
—
—
—
0
0
57
464
1.24
0.82
1.4
1.9
1.56
1.57
g/l
0.05
48
409
6
32
1.88
0.82
1.0
1.1
1.07
1.08
ratio
—
6
27
153
1363
1.15
0.81
1.5
1.3
11.16
13.84
u/ml
0.18
60
497
21
147
1.44
0.80
1.2
1.6
—
—
—
0
0
10
163
0.61
0.79
1.1
1.2
1.47
1.54
g/l
—
10
163
0
26
0.00
0.78
0.0
1.2
—
—
—
0
0
0
27
0.00
0.77
0.0
1.2
—
—
—
0
0
10
59
1.70
0.76
1.6
1.1
—
—
—
0
0
208
1901
1.12
0.75
3.5
3.5
0.67
0.78
ug/l
1.44
140
1307
7
38
1.85
0.73
6.9
2.5
564.43
787.26
u/ml
—
7
38
10
60
1.67
0.72
1.6
1.1
—
—
—
0
0
10
60
1.67
0.72
1.6
1.1
—
—
—
0
0
5
26
1.93
0.70
1.0
1.0
984.80
1650.12
miu/ml
—
5
26
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
41
1.71
0.70
1.0
1.2
—
—
—
0
0
7
41
1.71
0.70
1.0
1.0
—
—
—
0
0
137
1226
1.14
0.70
8.1
5.8
1.02
1.02
mmol/l
0.02
131
1121
9
58
1.56
0.70
1.7
1.1
—
—
—
0
0
60
503
1.21
0.68
2.7
2.5
45.47
20.75
au/ml
—
7
36
200
1835
1.12
0.68
3.4
3.1
2.44
2.46
mmol/l
1.28
181
1643
7
43
1.63
0.67
1.6
3.3
264.29
649.78
e6/l
—
7
36
13
86
1.52
0.66
1.1
1.1
8.49
7.23
mmol/l
—
7
72
20
145
1.39
0.66
1.3
1.3
—
—
—
0
0
11
70
1.58
0.65
1.6
1.1
—
—
—
0
0
78
674
1.17
0.64
1.4
1.6
—
—
—
0
0
8
49
1.64
0.62
1.5
1.6
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
331.46
—
0
13
225
2098
1.10
0.57
2.3
2.5
—
—
—
0
0
23
176
1.31
0.57
1.3
1.6
—
—
—
0
0
24
185
1.31
0.56
1.1
1.4
3.69
3.69
mmol/l
0.01
24
173
27
212
1.28
0.56
1.1
1.4
526.78
563.08
mg/l
0.27
27
195
15
107
1.41
0.55
1.2
1.3
0.64
0.66
nmol/l
0.05
15
100
18
133
1.36
0.55
1.4
1.2
—
—
—
0
0
6
38
1.58
0.54
1.5
1.1
—
—
—
0
0
70
611
1.16
0.53
5.3
6.8
24.28
24.50
mmol/l
0.34
65
585
13
91
1.43
0.53
1.2
1.8
—
—
—
0
0
10
66
1.52
0.52
1.5
1.7
—
—
—
0
0
10
66
1.52
0.52
1.6
1.1
—
—
—
0
0
13
180
0.72
0.51
1.2
1.4
—
—
—
0
0
13
180
0.72
0.51
1.2
1.4
—
—
—
0
0
25
197
1.28
0.51
1.3
1.2
—
—
—
0
0
39
326
1.21
0.49
1.1
1.0
—
—
—
0
0
103
930
1.12
0.49
3.9
3.8
1.96
1.94
mmol/l
0.02
92
798
17
128
1.33
0.48
1.2
1.2
238.25
275.86
u/ml
—
8
70
7
47
1.49
0.47
1.6
1.6
—
—
—
0
0
123
1126
1.11
0.46
5.1
7.9
5.02
5.12
kpa
0.71
117
1082
123
1127
1.11
0.46
5.1
7.9
13.25
12.01
kpa
1.37
116
1086
122
1120
1.10
0.44
5.0
7.9
0.37
0.96
mmol/l
1.28
99
919
19
241
0.78
0.44
3.2
1.8
4.37
5.32
mg/l
0.15
14
196
76
681
1.13
0.42
2.7
3.1
58.32
63.24
ml/min/173m2
0.57
40
299
12
87
1.38
0.42
1.1
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
7.85
—
0
16
213
2016
1.07
0.39
2.8
2.8
3.96
5.28
e6/l
1.25
187
1852
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
49
429
1.15
0.39
5.3
3.7
1.02
1.02
ratio
0.98
43
401
24
197
1.22
0.38
3.0
2.4
126.40
77.97
ug/min
—
10
112
13
98
1.33
0.37
1.2
1.8
—
—
—
0
0
9
71
1.27
0.36
1.0
1.1
—
—
—
0
0
38
329
1.16
0.35
2.1
1.8
—
—
—
0
0
6
44
1.37
0.34
1.2
1.1
—
13.30
—
0
20
31
361
0.85
0.34
2.4
1.7
—
—
—
0
0
120
1119
1.08
0.33
1.6
2.0
—
—
—
0
0
6
47
1.28
0.32
2.2
2.4
—
—
—
0
0
24
203
1.19
0.30
1.3
1.6
—
—
—
0
0
7
56
1.25
0.29
1.6
1.6
—
—
—
0
0
51
459
1.12
0.29
1.3
1.5
—
—
—
0
0
27
232
1.17
0.29
1.3
1.7
—
—
—
0
0
25
214
1.17
0.28
2.8
2.4
125.90
126.09
g/l
0.01
20
164
30
261
1.15
0.28
1.4
1.6
—
—
—
0
0
50
452
1.11
0.27
1.3
1.2
152.09
155.20
u/ml
0.02
16
178
15
122
1.23
0.27
1.4
1.7
—
—
—
0
0
5
72
0.69
0.26
1.2
1.1
90.60
99.86
%
—
5
66
5
73
0.68
0.26
1.4
1.1
—
—
—
0
0
22
189
1.17
0.24
1.2
1.3
—
—
—
0
0
38
421
0.90
0.23
1.8
1.8
3.44
3.49
mmol/l
0.09
28
318
328
3194
1.04
0.23
4.1
4.2
257.99
120.39
e6/l
0.36
238
2307
7
94
0.74
0.22
1.1
1.1
—
—
—
0
0
5
41
1.22
0.22
2.6
1.7
37.80
40.72
g/l
—
5
41
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
27
239
1.13
0.21
1.3
1.7
—
—
—
0
0
36
397
0.90
0.20
2.2
1.8
—
—
—
0
0
197
1902
1.05
0.20
4.1
4.3
1.02
1.02
kg/l
0.32
128
1267
0
14
0.00
0.20
0.0
1.4
—
61.60
—
0
14
0
14
0.00
0.20
0.0
1.1
—
0.64
—
0
8
0
14
0.00
0.20
0.0
1.0
—
19.70
—
0
14
9
112
0.80
0.20
1.0
1.0
—
—
—
0
0
6
49
1.23
0.20
1.2
1.9
—
—
—
0
0
9
115
0.78
0.20
5.4
5.6
327.67
354.45
umol/l
—
9
106
23
260
0.88
0.19
1.2
1.3
—
—
—
0
0
6
52
1.15
0.19
1.2
1.5
76.83
82.37
umol/l
—
6
52
21
238
0.88
0.18
4.4
3.2
2.00
1.79
index
0.06
13
125
18
156
1.16
0.18
1.4
1.8
—
—
—
0
0
294
2870
1.04
0.18
3.5
3.6
47.14
91.43
e6/l
0.88
230
2224
7
58
1.21
0.18
1.7
1.2
—
—
—
0
0
26
233
1.12
0.17
1.5
1.6
—
—
—
0
0
24
214
1.12
0.17
1.5
1.2
—
—
—
0
0
96
1007
0.95
0.17
4.6
4.3
17.39
19.36
ug/l
0.09
82
832
20
226
0.88
0.17
1.1
1.2
—
—
—
0
0
7
63
1.11
0.17
1.0
1.0
267.86
293.72
mg/l
—
7
53
20
177
1.13
0.16
1.3
1.6
—
—
—
0
0
37
341
1.09
0.16
4.2
2.9
0.20
1.32
g/l
3.72
32
296
29
318
0.91
0.16
1.5
1.7
0.13
0.34
mg/l
—
7
151
27
297
0.91
0.15
1.1
1.3
—
—
—
0
0
23
207
1.11
0.15
1.5
1.6
—
—
—
0
0
9
81
1.11
0.15
1.2
1.5
—
—
—
0
0
9
81
1.11
0.15
1.2
1.5
—
—
—
0
0
9
81
1.11
0.15
1.2
1.5
—
—
—
0
0
76
798
0.95
0.15
3.2
2.4
39.13
42.29
u/l
0.13
67
661
13
150
0.86
0.14
2.0
2.0
—
—
—
0
0
12
103
1.17
0.13
3.6
3.8
—
—
—
0
0
8
96
0.83
0.13
1.9
2.6
—
—
—
0
0
84
877
0.95
0.13
5.3
7.6
1.37
1.35
mmol/l
0.06
84
861
13
113
1.15
0.13
1.2
1.1
1.59
1.53
g/l
0.22
13
100
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
30
324
0.92
0.12
2.9
2.5
0.33
0.37
iu/ml
0.20
18
170
15
168
0.89
0.11
1.6
1.8
182.33
205.64
pmol/l
0.57
15
157
12
105
1.14
0.11
1.2
1.4
—
—
—
0
0
12
105
1.14
0.11
1.2
1.4
—
—
—
0
0
40
377
1.06
0.11
5.0
3.7
64623.83
3982.76
u/ml
0.47
35
327
10
86
1.16
0.11
1.5
1.9
—
—
—
0
0
15
134
1.12
0.11
7.3
6.1
13.03
12.24
mg/l
0.31
15
125
24
222
1.08
0.10
1.6
1.5
—
—
—
0
0
140
1434
0.97
0.09
3.1
3.3
2.56
2.18
e6/l
0.20
65
727
5
46
1.09
0.09
8.8
3.3
2.40
0.93
index
—
5
46
90
873
1.03
0.09
1.4
1.4
—
—
—
0
0
253
2493
1.02
0.08
3.3
3.5
1.70
0.42
e6/l
0.77
188
1858
27
253
1.07
0.08
1.6
1.7
—
—
—
0
0
6
57
1.05
0.08
1.0
1.3
—
—
—
0
0
12
107
1.12
0.08
1.2
1.4
—
—
—
0
0
66
637
1.04
0.08
5.6
9.8
93.47
93.76
%
0.08
66
631
10
113
0.88
0.08
1.2
1.5
6.83
6.57
mmol/l
—
10
107
21
226
0.93
0.08
1.0
1.2
—
—
—
0
0
5
60
0.83
0.08
3.4
1.5
172.40
94.54
ng/l
—
5
60
11
123
0.89
0.08
2.1
2.0
—
—
—
0
0
7
67
1.05
0.08
1.0
1.0
—
—
—
0
0
56
580
0.96
0.07
2.0
2.1
3.44
3.50
ratio
0.14
45
475
8
93
0.86
0.06
1.1
1.2
133.00
115.98
%
—
8
84
20
187
1.07
0.06
1.2
1.5
1367.86
818.63
e6/l
0.15
14
142
154
1563
0.98
0.05
2.8
3.1
5.05
1.02
e6/l
0.60
81
857
30
288
1.04
0.04
4.5
2.9
0.00
0.00
g/l
-0.00
24
252
218
2159
1.01
0.04
3.9
4.3
86.03
87.69
%
0.43
213
2116
24
229
1.05
0.04
1.6
2.3
85.75
92.06
%
0.62
24
221
36
348
1.04
0.04
2.9
2.9
—
—
—
0
0
25
242
1.03
0.02
1.4
1.6
18483.50
16472.76
e6/l
0.10
14
176
26
252
1.03
0.02
1.4
1.3
—
—
—
0
0
11
103
1.07
0.02
2.1
2.5
16.00
19.86
mg/l
—
5
36
31
318
0.97
0.02
1.5
1.3
—
—
—
0
0
80
808
0.99
0.01
1.6
1.7
1.56
1.57
%
0.06
67
680
11
104
1.06
0.01
1.3
1.5
—
—
—
0
0
11
104
1.06
0.01
1.3
1.5
—
—
—
0
0
19
184
1.03
0.00
1.2
1.4
8.09
66.21
e6/l
0.97
11
135
11
107
1.03
0.00
1.3
1.4
—
—
—
0
0
11
111
0.99
0.00
1.5
1.8
—
—
—
0
0
34
337
1.01
0.00
6.0
3.6
53.20
43.61
mg/l
0.18
28
290
34
337
1.01
0.00
6.0
3.5
42.42
67.12
mg/l
0.73
28
290
31
305
1.02
0.00
6.1
3.5
1.35
2.63
ratio
2.23
17
177
58
575
1.01
0.00
5.8
9.9
24.07
24.33
mmol/l
0.32
58
563
59
595
0.99
0.00
1.6
1.7
—
—
—
0
0
17
175
0.97
0.00
3.5
3.5
20.96
26.74
mg/l
0.45
12
120
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
0.38
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
8
81
0.99
-0.00
1.3
1.2
12.13
11.94
u/l
—
8
71
5
59
0.85
-0.00
1.0
1.3
—
—
—
0
0
5
57
0.88
-0.00
1.2
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
51
0.98
-0.00
2.4
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
6
65
0.92
-0.00
1.0
1.1
115.83
105.46
pmol/l
—
6
65
5
59
0.85
-0.00
1.0
1.3
—
—
—
0
0
7
69
1.01
-0.00
1.3
1.4
19.86
13.45
u/l
—
7
64
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
5
49
1.02
-0.00
4.2
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
21
210
1.00
-0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
-0.00
1.2
1.3
—
—
—
0
0
7
72
0.97
-0.00
2.1
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
6.10
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINOCHISISCYST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINOCHISISCYST | 0.746 [0.64, 0.86] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.087 |
During the follow-up period (1.1.1998 — 31.12.2019), 279 out of 2255 females with H7_RETINOCHISISCYST died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINOCHISISCYST | 0.806 [0.7, 0.93] | 0.003 |
| Birth year | 0.988 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 391 out of 2318 males with H7_RETINOCHISISCYST died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINOCHISISCYST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.069% | 0.188% |
| 5 | 0.386% | 0.962% |
| 10 | 0.962% | 2.488% |
| 15 | 1.992% | 4.683% |
| 20 | 3.487% | 8.127% |
Relationships between endpoints
↥Index endpoint: H7_RETINOCHISISCYST – Retinoschisis and retinal cysts
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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