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Other disorders of optic disc

DOID EFO Endpoint Browser PheWeb

H7_OPTICDISCOTH

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — H47.3
  • Hospital discharge: ICD-9 — 3772
  • Cause of death: ICD-10 — H47.3
  • Cause of death: ICD-9 — 3772

2 out of 7 registries used, show all original rules.

578

4. Check minimum number of events

None

578

5. Include endpoints

None

578

6. Filter based on genotype QC (FinnGen only)

527

Control definitions (FinnGen only)

Control exclude
H7_OPTNERVE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H47
Name in latin
Aliae morbositates papillae/disci nervi optici non specificatae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3105 1814 1282
Only index persons 2939 1737 1202
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.04
Only index persons 0.06 0.06 0.05
Median age at first event (years)
Whole population 41.97 39.97 44.82
Only index persons 42.63 40.60 45.56

-FinnGen-

Key figures

All Female Male
Number of individuals 527 330 197
Unadjusted period prevalence (%) 0.11 0.12 0.09
Median age at first event (years) 53.51 50.45 58.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
545
Matched controls
5450
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H47.3
ICD-10 Finland
Other disorders of optic disc
4503599627370496.0
307.7
538
*
XCK00
NOMESCO Finland
Perimetry
14.9
135.3
134
117
H47.1
ICD-10 Finland
Papilloedema, unspecified
1189.8
103.8
98
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.7
76.6
109
153
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
12.0
71.7
77
74
XCK10
NOMESCO Finland
Photography of fundus of eye
6.7
71.6
133
249
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.5
70.5
137
268
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.2
51.6
189
615
XCD10
NOMESCO Finland
Electrophysiological examination of eye
12.7
47.8
48
41
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.0
44.0
110
264
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
11.9
39.3
41
37
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
+∞
36.9
35
*
CS494
NOMESCO Finland
Other visual field testing
9.8
34.3
41
45
H53.4
ICD-10 Finland
Visual field defects
10.0
34.0
40
43
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
11.6
32.3
34
31
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.9
31.0
44
60
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
60.3
29.5
34
6
H47.2
ICD-10 Finland
Optic atrophy
+∞
28.4
27
*
Z3229
NOMESCO Finland
Other healthcare associate professional
4.0
24.7
78
220
S01EC01
ATC
acetazolamide; systemic
8.8
23.3
30
36
H46
ICD-10 Finland
Optic neuritis
+∞
23.1
22
*
H53.1
ICD-10 Finland
Subjective visual disturbances
3.9
23.1
73
206
TAB00
NOMESCO Finland
Lumbar puncture
4.5
21.2
54
129
G93.2
ICD-10 Finland
Benign intracranial hypertension
114.4
20.7
22
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
16.8
74
258
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
21.8
16.1
23
11
H53.9
ICD-10 Finland
Visual disturbance, unspecified
4.2
15.1
41
103
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
13.5
242
1561
ZXA10
NOMESCO Finland
Bilateral
2.2
11.7
114
583
Z3231
NOMESCO Finland
Registered nurse
2.0
11.3
166
987
CS2P4
NOMESCO Finland
Optic nerve head imaging
13.2
10.7
18
14
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
5.0
10.6
23
48
R51.80
ICD-10 Finland
Headache
2.1
9.9
115
626
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
3.6
9.6
32
93
CK2P4
NOMESCO Finland
Optic nerve head light layer imaging (OCT)
28.0
8.5
11
*
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
8.7
8.4
17
20
3772A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Other disorders of optic disk
+∞
8.4
8
*
L04AX01
ATC
azathioprine; systemic
3.4
8.0
29
89
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.3
8.0
63
293
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.7
8.0
44
173
XCH00
NOMESCO Finland
Eye pressure measurement
3.1
7.7
32
107
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
15.3
7.7
12
8
H02AB06
ATC
prednisolone; systemic
1.7
7.7
249
1829
WX402
NOMESCO Finland
General anaesthesia
1.8
7.6
134
832
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.5
7.0
17
39
ZXD10
NOMESCO Finland
Scheduled procedure
1.7
7.0
191
1338
114
Kela drug reimbursment
Glaucoma
2.5
6.9
43
180
R06AE07
ATC
cetirizine; oral
1.6
6.8
243
1813
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
4.4
6.8
17
40
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
40.6
6.8
8
*
H26.4
ICD-10 Finland
After-cataract
2.3
6.5
49
224
H57.1
ICD-10 Finland
Ocular pain
2.8
6.5
32
119
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
6.4
116
723
Z2221
NOMESCO Finland
Medical doctor
1.7
6.4
147
981
N64.4
ICD-10 Finland
Mastodynia
3.0
6.4
27
92
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
6.3
71
379
R4190
NOMESCO Finland
Nutritional therapy
2.8
6.3
31
115
CKC12
NOMESCO Finland
Photocoagulation of retina
2.9
6.3
29
104
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
3.3
6.2
23
72
H52.0
ICD-10 Finland
Hypermetropia
3.5
6.1
20
58

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
31
49
6.65
19.02
1.3
1.1
—
—
—
0
0
48
122
4.22
17.38
1.3
1.2
33.03
1026.98
e6/l
0.55
34
96
43
104
4.40
16.59
1.4
1.2
—
—
—
0
0
46
120
4.09
16.08
1.3
1.1
18.59
14.23
e6/l
0.10
32
91
25
39
6.67
15.50
1.2
1.1
235.20
218.56
mg/l
0.28
20
34
25
41
6.34
14.78
1.2
1.1
39.21
35.05
mg/l
0.23
20
31
22
33
6.91
14.12
1.4
1.2
0.60
0.51
ratio
0.63
12
17
292
2001
1.99
13.79
6.5
4.8
36.83
36.31
g/l
0.94
278
1894
244
1623
1.91
12.08
6.9
6.0
—
—
—
0
0
79
349
2.48
11.31
2.6
2.4
30.00
15.97
au/ml
—
5
31
317
2332
1.86
11.12
10.8
7.4
1.21
1.21
mmol/l
0.08
281
2034
213
1408
1.84
10.35
7.5
4.1
7.40
7.40
ph
1.54
150
969
25
58
4.47
10.15
1.2
1.2
—
—
—
0
0
357
2805
1.79
9.28
9.5
9.6
4.21
4.07
e9/l
0.48
296
2443
357
2817
1.77
9.02
6.4
5.3
6.47
6.59
mmol/l
0.54
333
2646
284
2108
1.73
8.86
10.2
7.1
1.21
1.21
mmol/l
0.52
271
1956
306
2319
1.73
8.85
7.4
6.4
8.48
8.68
%
0.60
289
2180
131
781
1.89
8.58
3.4
3.0
2.96
2.56
e6/l
0.18
64
376
303
2310
1.70
8.40
7.5
6.4
0.66
0.69
%
0.41
286
2165
323
2510
1.70
8.30
7.3
6.2
0.56
0.57
e9/l
0.52
272
2157
303
2320
1.69
8.18
7.4
6.3
3.03
2.85
%
0.53
287
2174
323
2522
1.69
8.04
7.3
6.2
0.04
0.04
e9/l
0.44
270
2167
197
1352
1.72
7.96
4.7
3.1
0.29
0.43
e6/l
0.33
140
971
303
2350
1.65
7.53
7.3
6.2
57.80
56.68
%
0.89
290
2247
279
2122
1.64
7.47
3.8
3.3
6.18
6.21
ph
0.15
132
1203
112
662
1.87
7.45
4.7
2.5
23.10
23.79
%
0.16
106
629
306
2384
1.65
7.44
7.5
6.3
27.43
28.59
%
1.02
293
2269
328
2602
1.65
7.41
7.4
6.6
0.21
0.19
e9/l
0.63
280
2269
188
1299
1.68
7.28
4.5
3.0
—
0.00
estimate
—
0
8
423
3601
1.78
7.23
9.5
7.9
77.23
79.39
u/l
0.48
403
3413
324
2573
1.64
7.19
7.4
6.3
1.85
1.99
e9/l
1.16
282
2274
198
1394
1.66
7.10
1.9
2.1
295.78
240.77
u/l
0.12
190
1323
168
1133
1.70
7.09
2.2
1.8
2.11
1.24
mg/l
0.37
135
882
247
1840
1.63
7.07
5.5
3.9
98.41
95.06
e6/l
0.02
170
1256
15
22
6.98
6.55
4.3
4.5
1997.93
714.59
u/ml
0.38
15
22
282
2200
1.58
6.46
3.1
2.5
80.17
74.98
nmol/l
2.03
264
1995
134
869
1.72
6.45
5.1
4.0
656.99
370.12
ng/l
0.27
88
639
169
1166
1.65
6.45
3.8
3.5
—
0.18
—
0
11
517
4772
2.62
6.18
22.7
16.5
139.74
139.68
mmol/l
0.20
508
4673
213
1570
1.59
6.14
4.7
3.2
56.83
101.43
e6/l
0.40
159
1186
391
3318
1.63
6.09
5.6
4.4
—
3.81
—
0
5
517
4777
2.60
6.07
23.2
16.7
3.94
3.95
mmol/l
0.64
507
4665
121
777
1.72
6.00
4.6
2.4
13.20
13.81
umol/l
0.34
116
728
26
90
2.98
5.97
5.7
2.8
—
—
—
0
0
308
2479
1.56
5.97
4.5
3.1
116.14
105.17
ug/l
0.41
294
2337
515
4759
2.49
5.89
20.0
14.2
22.97
22.22
mg/l
0.19
441
3845
325
2654
1.56
5.85
4.5
3.8
0.00
0.00
estimate
-0.00
60
528
75
421
1.91
5.79
2.8
2.3
10.26
10.33
g/l
0.05
66
393
319
2602
1.54
5.71
4.5
3.7
0.00
0.00
estimate
-0.00
61
561
322
2639
1.54
5.59
4.5
3.7
0.00
2.87
estimate
0.50
62
566
73
411
1.90
5.58
12.6
10.7
—
—
—
0
0
199
1481
1.54
5.33
5.9
6.1
—
—
—
0
0
81
479
1.81
5.31
7.7
4.0
7.37
7.38
ph
0.89
52
278
113
735
1.68
5.30
1.5
1.4
423.64
518.11
titre
0.30
22
169
175
1268
1.56
5.28
2.3
2.2
2.61
2.89
mg/l
0.65
159
1094
215
1635
1.52
5.18
3.2
3.1
2.35
2.36
mmol/l
0.26
202
1484
78
460
1.81
5.16
2.1
2.4
31.36
33.35
u/l
0.23
69
375
29
116
2.58
5.13
1.3
1.4
254.26
245.27
u/ml
0.06
19
60
9
9
10.14
5.04
1.0
1.0
6.10
5.86
mg/g
—
9
9
305
2504
1.50
5.01
6.3
6.5
11.15
11.66
umol/l
0.33
288
2377
277
2235
1.49
4.93
13.6
10.7
0.00
0.00
e9/l
0.12
216
1819
165
1197
1.54
4.89
4.9
4.3
—
—
—
0
0
54
290
1.96
4.76
1.6
2.4
—
—
—
0
0
282
2303
1.47
4.61
3.1
2.8
—
—
estimate
—
0
0
21
77
2.80
4.40
1.0
1.2
—
—
—
0
0
28
120
2.41
4.32
7.1
10.3
1.00
1.28
mmol/l
1.61
23
106
74
457
1.72
4.18
8.0
4.0
1.47
1.70
mmol/l
0.25
60
389
79
497
1.69
4.17
9.2
10.1
0.74
0.88
mmol/l
0.11
61
425
30
135
2.29
4.16
1.8
1.2
—
—
—
0
0
100
670
1.60
4.13
1.3
1.2
—
—
—
0
0
8
10
8.10
4.07
1.0
1.0
—
—
—
0
0
99
664
1.60
4.07
2.3
2.0
—
—
—
0
0
145
1064
1.49
3.97
3.9
2.6
3.84
6.59
e6/l
1.62
131
962
250
2035
1.42
3.95
2.2
2.0
98.85
96.55
pmol/l
0.29
121
1032
214
1695
1.43
3.93
3.2
3.2
27.84
30.77
u/l
1.13
201
1598
372
3255
1.45
3.91
4.3
3.9
—
0.14
—
0
7
168
1277
1.46
3.83
3.5
3.2
1554.87
1050.72
ng/l
0.60
135
1073
486
4510
1.72
3.80
6.0
5.3
1.78
1.88
mu/l
1.08
455
4201
187
1453
1.44
3.79
4.1
3.5
98.55
49.14
mg/l
1.19
121
932
249
2039
1.41
3.74
18.5
11.3
1.23
1.18
inr
0.80
196
1663
79
512
1.64
3.72
9.2
9.9
4.91
5.10
kpa
1.30
74
499
79
512
1.64
3.72
9.3
9.9
12.62
12.53
kpa
0.06
74
501
78
509
1.62
3.58
9.3
10.0
7.42
7.42
ph
0.28
39
285
127
928
1.48
3.51
4.4
2.8
511.49
530.14
mosm/kgh2o
0.52
111
804
199
1586
1.40
3.43
2.6
2.3
—
—
—
0
0
84
565
1.58
3.40
1.9
3.0
8.15
7.54
umol/l
0.07
72
490
133
987
1.46
3.39
1.4
1.3
15.70
30.89
iu/ml
2.39
35
292
58
358
1.69
3.30
1.8
2.8
65.55
67.31
g/l
0.96
53
336
65
415
1.64
3.26
4.4
5.5
0.00
0.19
%
1.24
16
96
186
1478
1.39
3.23
5.2
4.2
18.97
8.30
mg/mmol
1.13
118
919
154
1186
1.42
3.20
2.4
2.2
—
—
—
0
0
32
166
1.99
3.16
1.3
1.3
—
—
—
0
0
17
67
2.59
3.15
1.1
1.2
—
—
—
0
0
155
1200
1.41
3.11
2.9
2.8
331.33
338.20
umol/l
0.36
138
1067
178
1416
1.38
3.04
3.0
2.8
—
—
—
0
0
470
4378
1.53
2.99
7.0
6.1
39.59
38.72
mmol/mol
1.09
449
4142
537
5226
2.88
2.99
29.5
22.0
4.51
4.52
e12/l
0.29
524
5112
537
5226
2.88
2.99
29.6
22.0
6.89
6.73
e9/l
0.67
524
5113
537
5223
2.92
2.98
29.6
22.0
255.28
253.99
e9/l
0.18
526
5122
28
142
2.02
2.95
1.9
2.8
—
—
—
0
0
21
95
2.26
2.93
10.4
2.7
10.92
8.13
pmol/l
0.72
21
95
201
1639
1.36
2.92
4.1
3.4
8.02
7.76
mmol/l
0.30
177
1408
377
3384
1.37
2.88
3.2
3.4
41.87
44.47
u/l
0.39
363
3212
12
39
3.12
2.78
2.7
2.5
—
—
—
0
0
62
408
1.59
2.77
4.2
4.9
0.76
0.56
%
0.33
17
117
5
6
8.40
2.75
1.0
1.0
—
—
—
0
0
20
92
2.22
2.70
1.6
1.9
6.20
5.03
mmol/24h
0.70
20
80
25
126
2.03
2.70
1.8
1.5
—
—
—
0
0
19
87
2.23
2.60
1.4
1.4
—
—
—
0
0
98
721
1.44
2.59
2.9
2.4
177.51
116.34
ug/g
0.61
84
576
520
4997
1.89
2.54
14.6
11.3
25.10
25.92
u/l
0.60
515
4855
18
82
2.24
2.50
1.4
1.2
1.73
3.49
u/ml
1.47
11
37
7
16
4.42
2.48
1.3
2.7
0.55
0.61
mmol/l
—
7
16
7
16
4.42
2.48
1.0
1.1
—
—
—
0
0
14
57
2.49
2.46
3.0
2.1
—
—
—
0
0
80
574
1.46
2.41
1.9
1.6
—
—
—
0
0
79
566
1.46
2.40
1.4
1.4
—
—
—
0
0
33
191
1.77
2.39
1.8
1.8
—
—
—
0
0
73
516
1.48
2.37
2.2
1.9
384.00
381.10
nmol/l
0.04
68
480
73
516
1.48
2.37
2.1
2.9
1.77
1.84
%
0.20
64
467
43
269
1.65
2.37
4.2
3.5
153.20
164.98
ng/l
0.07
35
245
43
271
1.64
2.31
1.4
1.2
—
—
—
0
0
16
73
2.23
2.23
2.9
3.3
4.76
4.34
e9/l
0.17
16
73
71
507
1.46
2.20
1.5
1.4
—
—
—
0
0
25
137
1.86
2.17
4.4
4.0
34.00
61.77
mg/l
0.68
19
121
25
137
1.86
2.17
4.4
4.0
30.75
89.57
mg/l
0.78
19
122
59
407
1.50
2.17
3.9
5.1
0.07
0.15
%
0.52
15
105
62
435
1.48
2.11
4.0
4.9
0.78
0.93
%
0.26
18
136
11
43
2.59
2.09
1.3
1.1
—
—
—
0
0
116
911
1.35
2.08
1.9
1.7
433.81
22109711.47
pmol/l
0.74
95
787
56
386
1.50
2.07
1.8
1.4
—
—
—
0
0
513
4941
1.65
2.05
16.2
12.7
—
—
—
0
0
56
387
1.50
2.05
2.1
2.8
69.75
73.18
e9/l
0.31
37
278
11
44
2.53
2.02
1.1
1.2
—
—
—
0
0
9
32
2.84
2.01
1.2
3.4
1826.44
904.38
mg
—
9
32
91
692
1.38
2.00
1.9
1.6
—
—
—
0
0
34
211
1.65
1.96
1.4
1.4
—
—
—
0
0
50
341
1.51
1.95
2.2
1.6
0.99
1.38
g/l
1.55
43
318
415
3868
1.31
1.91
4.9
4.3
14.72
14.64
pmol/l
0.30
382
3549
14
65
2.18
1.89
1.1
1.2
—
—
—
0
0
23
129
1.82
1.88
1.7
2.0
4.36
3.91
iu/l
—
8
52
491
4699
1.45
1.86
6.2
5.6
2.64
2.74
mmol/l
1.82
464
4401
53
371
1.47
1.84
1.5
1.2
555.40
301.30
u/ml
0.41
46
343
115
919
1.32
1.83
1.4
1.3
4.54
11.26
u/ml
1.74
42
359
26
153
1.73
1.83
1.7
1.2
—
—
—
0
0
11
47
2.37
1.78
6.0
3.6
12.96
12.08
%
0.24
11
47
22
124
1.81
1.78
4.0
3.8
1.05
2.21
ratio
—
9
72
180
1532
1.26
1.75
2.6
2.6
58.35
63.39
u/l
0.43
170
1426
12
54
2.25
1.75
4.4
2.7
20.38
22.03
nmol/l
0.26
12
49
9
36
2.52
1.74
1.1
1.2
—
—
—
0
0
145
1203
1.28
1.74
1.7
1.4
2.23
2.21
g/l
0.03
77
731
36
236
1.56
1.70
1.7
2.1
2.98
6.00
iu/ml
—
6
50
232
2039
1.24
1.69
2.0
1.9
1.29
1.35
mmol/l
0.65
196
1749
485
4648
1.39
1.65
5.4
4.9
4.58
4.66
mmol/l
0.92
464
4374
143
1193
1.27
1.64
2.2
2.1
—
—
—
0
0
158
1335
1.26
1.63
1.7
1.6
22.28
20.86
nmol/l
0.21
138
1134
59
433
1.41
1.62
1.7
2.6
0.23
0.22
g/l
0.18
54
416
32
207
1.58
1.61
1.1
1.2
—
—
—
0
0
6
20
3.02
1.58
1.8
1.5
—
—
—
0
0
90
711
1.32
1.56
1.9
1.7
1140.15
1192.71
nmol/l
0.23
67
535
159
1352
1.25
1.54
1.6
1.3
1.69
1.81
u/ml
0.04
42
358
42
292
1.47
1.54
1.4
1.4
25.00
20.64
iu/l
0.38
35
241
122
1006
1.27
1.53
2.0
1.7
—
—
—
0
0
48
344
1.43
1.51
1.2
1.2
—
—
—
0
0
6
21
2.88
1.51
2.5
1.9
—
—
—
0
0
111
908
1.28
1.49
2.5
2.6
2.44
2.44
mmol/l
0.27
96
808
80
628
1.32
1.45
9.6
7.3
104.90
104.29
mmol/l
0.61
80
628
5
16
3.14
1.44
1.4
1.3
26.60
26.56
s
—
5
16
31
205
1.54
1.44
1.7
1.6
31.93
9.98
u/ml
—
6
42
59
443
1.37
1.43
1.8
1.5
—
—
—
0
0
482
4635
1.35
1.42
5.3
4.8
1.46
1.47
mmol/l
0.18
456
4337
12
60
2.02
1.39
4.9
2.7
—
—
—
0
0
5
17
2.96
1.36
1.0
1.3
—
—
—
0
0
15
83
1.83
1.32
1.3
1.3
—
—
—
0
0
13
69
1.91
1.29
1.0
1.1
1.56
1.44
g/l
0.58
13
64
195
1723
1.21
1.28
3.6
3.6
70.58
55.37
ng/l
0.12
132
1127
6
25
2.42
1.24
5.2
1.3
194.17
74.86
ng/l
—
6
25
6
25
2.42
1.24
3.7
2.5
4.12
3.62
ug/l
—
6
25
50
375
1.37
1.24
2.2
2.3
5.84
6.16
ph
1.70
32
245
47
349
1.38
1.24
11.5
3.6
1.22
1.23
mmol/l
0.37
40
301
9
45
2.02
1.24
1.1
1.0
—
—
—
0
0
54
411
1.35
1.23
6.6
3.6
—
—
—
0
0
19
116
1.66
1.23
1.4
1.4
6726.40
15214.83
e6/l
—
10
82
10
49
2.06
1.22
1.0
1.2
—
—
—
0
0
6
26
2.32
1.19
1.0
1.1
—
—
—
0
0
20
126
1.61
1.16
1.1
1.1
—
—
—
0
0
61
478
1.31
1.15
1.2
1.2
—
—
—
0
0
14
80
1.77
1.14
1.1
1.1
—
—
—
0
0
136
1176
1.21
1.11
6.2
4.9
—
—
—
0
0
17
104
1.66
1.10
4.1
3.1
58.12
58.51
%
0.04
17
104
8
41
1.97
1.09
2.1
2.7
—
—
—
0
0
8
41
1.97
1.09
2.3
1.9
41.88
40.44
%
—
8
41
470
4537
1.26
1.08
5.3
4.8
5.90
5.87
mmol/l
0.15
438
4191
33
237
1.42
1.07
1.0
1.1
—
—
—
0
0
10
53
1.90
1.02
1.0
1.2
—
—
—
0
0
36
266
1.38
1.01
1.1
1.1
—
—
—
0
0
17
108
1.59
0.97
1.2
1.1
—
—
—
0
0
17
108
1.59
0.97
1.2
1.1
—
—
—
0
0
44
339
1.32
0.96
4.6
4.8
7.42
7.42
ph
0.06
37
274
20
133
1.52
0.95
1.3
1.2
2.86
3.20
u/ml
0.07
11
78
7
37
1.90
0.94
1.0
1.1
—
—
—
0
0
174
1563
1.17
0.91
1.5
1.6
—
—
—
0
0
75
624
1.23
0.90
1.4
1.4
—
—
—
0
0
6
29
2.08
0.89
1.3
1.3
—
—
—
0
0
71
589
1.24
0.88
1.3
1.3
—
—
—
0
0
210
1918
1.15
0.88
2.2
2.1
—
—
—
0
0
8
43
1.87
0.87
1.3
1.1
—
—
—
0
0
15
96
1.58
0.85
1.3
1.8
—
—
—
0
0
33
249
1.35
0.84
5.2
2.7
0.72
0.63
%
0.87
33
249
216
1986
1.15
0.81
4.6
3.5
0.02
0.01
estimate
0.16
55
476
33
251
1.34
0.80
6.4
6.6
—
—
—
0
0
27
200
1.37
0.78
2.7
4.4
37.00
36.90
°c
1.38
27
200
6
34
1.77
0.76
1.0
1.5
—
—
—
0
0
9
54
1.68
0.75
7.9
3.3
—
—
—
0
0
21
288
0.72
0.74
1.4
1.8
—
—
—
0
0
82
704
1.19
0.74
1.6
1.6
—
—
—
0
0
7
39
1.80
0.72
1.3
1.1
—
—
—
0
0
54
446
1.23
0.72
2.1
2.1
0.00
0.03
estimate
0.50
12
104
161
1473
1.13
0.64
4.3
3.2
0.00
0.01
estimate
1.08
53
462
8
130
0.61
0.64
1.0
1.4
75.13
188.22
pmol/l
—
8
125
22
291
0.75
0.64
1.4
2.0
—
—
—
0
0
22
289
0.75
0.62
1.3
2.0
—
—
—
0
0
5
30
1.67
0.61
1.0
2.2
16.74
17.07
%
—
5
30
22
288
0.75
0.60
1.3
2.0
—
—
—
0
0
452
4404
1.15
0.60
4.5
4.1
1.28
1.28
mmol/l
0.02
424
4089
0
21
0.00
0.60
0.0
2.2
—
—
—
0
0
34
273
1.26
0.59
3.1
2.6
41.83
44.33
u/ml
0.04
34
260
8
53
1.52
0.58
1.8
1.3
—
—
—
0
0
36
292
1.25
0.58
2.7
2.3
4740.91
6442.76
u/l
0.20
15
124
6
36
1.67
0.57
1.2
1.3
4.13
8.44
u/l
—
6
31
6
37
1.63
0.55
1.0
1.5
199.88
158.83
pmol/l
—
6
37
137
1253
1.12
0.55
5.4
5.2
1.82
2.26
ug/l
0.55
126
1134
27
213
1.28
0.55
2.0
2.3
—
—
—
0
0
21
272
0.76
0.55
1.2
2.0
—
—
—
0
0
9
62
1.46
0.53
7.3
2.2
10.44
10.36
mmol/l
—
9
62
21
269
0.77
0.51
2.0
1.7
—
—
—
0
0
6
41
1.47
0.50
1.3
1.1
112.00
107.71
pmol/l
—
6
41
10
68
1.48
0.47
1.0
1.3
—
112.54
—
0
5
11
77
1.44
0.46
1.6
1.9
—
—
—
0
0
18
231
0.77
0.45
1.2
2.1
—
—
—
0
0
10
69
1.46
0.44
1.0
1.0
—
—
—
0
0
5
31
1.62
0.43
1.6
1.5
62.20
72.71
umol/l
—
5
31
5
31
1.62
0.43
1.4
1.3
—
16181.93
—
0
14
8
57
1.41
0.42
1.4
2.2
31.88
32.93
pg
—
8
57
20
159
1.27
0.40
1.8
1.6
—
—
—
0
0
48
419
1.16
0.40
2.0
1.8
3.28
3.46
mmol/l
0.56
36
301
12
88
1.37
0.40
2.7
1.4
20.09
23.53
u/l
0.18
12
72
66
590
1.13
0.40
1.7
1.8
—
—
—
0
0
18
142
1.28
0.39
1.2
1.1
—
—
—
0
0
5
36
1.39
0.38
1.2
1.7
—
—
—
0
0
16
125
1.29
0.37
2.4
2.8
2.33
1.89
index
—
9
70
6
42
1.43
0.35
1.0
1.2
—
—
—
0
0
14
108
1.30
0.35
4.6
4.1
—
—
—
0
0
152
1434
1.08
0.34
4.9
3.7
0.00
0.00
estimate
0.50
58
533
12
91
1.33
0.34
1.3
1.1
20.86
5.96
u/ml
—
5
41
81
743
1.11
0.33
1.7
1.8
—
—
—
0
0
6
86
0.69
0.33
1.0
1.1
—
—
—
0
0
6
46
1.31
0.33
2.0
3.2
—
—
—
0
0
18
146
1.24
0.32
1.0
1.1
—
—
—
0
0
10
132
0.75
0.32
1.3
2.7
—
—
—
0
0
26
221
1.19
0.31
1.4
1.3
324.50
267.01
miu/ml
—
6
109
19
157
1.22
0.30
1.8
1.4
—
—
—
0
0
8
62
1.29
0.28
1.1
1.1
—
—
nmol/l
—
0
0
45
404
1.12
0.28
1.3
1.2
112.81
160.26
u/ml
0.62
14
164
37
416
0.88
0.27
3.9
4.0
7.38
7.34
ph
1.77
28
303
12
95
1.27
0.26
1.2
1.1
—
—
—
0
0
10
77
1.30
0.26
1.1
1.5
—
—
—
0
0
10
77
1.30
0.26
1.1
1.5
—
—
—
0
0
10
77
1.30
0.26
1.1
1.5
—
—
—
0
0
10
77
1.30
0.26
1.1
1.5
—
—
—
0
0
189
1965
0.94
0.26
3.4
3.0
—
—
—
0
0
10
78
1.29
0.24
1.1
1.2
29.78
23.66
u/l
—
10
68
20
171
1.18
0.23
3.9
3.6
229.62
331.43
mg/l
0.51
13
74
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
7.50
—
0
11
0
10
0.00
0.21
0.0
1.2
—
1.87
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
69.30
—
0
5
0
13
0.00
0.21
0.0
1.8
—
1.21
—
0
13
0
14
0.00
0.20
0.0
1.4
—
9.24
—
0
14
47
433
1.09
0.20
4.7
4.4
2.50
33.24
ug/l
1.01
37
356
26
231
1.13
0.20
2.3
1.8
—
—
—
0
0
6
50
1.20
0.19
2.5
1.1
0.86
1.52
nmol/l
—
6
44
6
52
1.16
0.19
5.7
2.4
106.33
105.54
mmol/l
—
6
52
6
52
1.16
0.19
5.7
2.4
1.19
1.19
mmol/l
—
6
52
6
52
1.16
0.19
5.7
2.4
4.00
3.98
mmol/l
—
6
52
7
63
1.11
0.17
1.0
1.6
37.11
30.47
ng/l
—
7
63
13
152
0.85
0.17
6.9
10.4
—
—
—
0
0
9
78
1.16
0.15
1.8
1.6
—
—
—
0
0
12
102
1.18
0.15
1.3
1.1
3.52
2.76
u/ml
—
7
52
9
82
1.10
0.15
3.3
4.0
81.44
366.99
u/ml
—
9
76
9
83
1.09
0.14
1.2
1.2
—
—
—
0
0
122
1178
1.05
0.14
3.7
3.6
1.02
1.02
kg/l
0.61
86
777
10
84
1.19
0.14
2.0
1.6
—
—
—
0
0
17
190
0.89
0.13
1.4
1.1
0.93
0.88
g/l
0.23
17
190
49
518
0.94
0.12
1.3
1.4
—
—
—
0
0
24
261
0.92
0.12
1.4
1.5
0.33
0.26
mg/l
—
9
107
77
743
1.04
0.10
3.5
3.1
0.74
0.75
ug/l
0.07
50
466
5
48
1.04
0.09
1.4
1.9
—
—
—
0
0
6
56
1.07
0.08
1.7
1.2
—
—
—
0
0
17
185
0.92
0.08
1.4
1.1
1.54
1.55
g/l
0.03
17
185
14
154
0.91
0.08
1.4
1.3
188.37
298.00
ug/g
—
8
88
17
182
0.93
0.05
1.1
1.1
0.74
0.69
ratio
—
5
20
11
100
1.10
0.05
1.8
1.5
0.52
0.38
nmol/l
—
6
79
20
211
0.95
0.04
1.3
2.7
—
—
—
0
0
26
251
1.04
0.02
5.3
5.1
—
—
—
0
0
26
252
1.03
0.02
2.8
2.2
0.00
0.01
estimate
—
9
86
12
127
0.94
0.01
1.7
1.4
—
—
—
0
0
12
115
1.04
0.00
1.2
1.1
17.17
6.39
u/ml
—
5
70
12
115
1.04
0.00
1.3
1.1
8.36
1.33
u/ml
—
6
67
0
9
0.00
0.00
0.0
1.7
—
57.11
—
0
9
5
49
1.02
0.00
1.4
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
40.00
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
16.74
—
0
5
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
7
75
0.93
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.0
—
0.22
—
0
5
6
61
0.98
-0.00
1.7
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
6.8
—
6.83
—
0
8

Mortality – FinRegistry

↥

Association

Association between endpoint H7_OPTICDISCOTH and mortality.

Females

Parameter HR [95% CI] p-value
H7_OPTICDISCOTH 1.21 [0.93, 1.57] 0.153
Birth year 0.995 [0.99, 1.0] 0.202

During the follow-up period (1.1.1998 — 31.12.2019), 102 out of 1503 females with H7_OPTICDISCOTH died.

Males

Parameter HR [95% CI] p-value
H7_OPTICDISCOTH 1.083 [0.84, 1.4] 0.538
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 1051 males with H7_OPTICDISCOTH died.

Mortality risk

Mortality risk for people of age

years, who have H7_OPTICDISCOTH.

N-year risk Females Males
1 0.144% 0.177%
5 0.814% 1.259%
10 1.812% 3.309%
15 3.528% 5.975%
20 6.072% 9.793%

Relationships between endpoints

↥

Index endpoint: H7_OPTICDISCOTH – Other disorders of optic disc

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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