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Vitamin B12 deficiency anemia due to intrinsic factor deficiency

Endpoint Browser PheWeb

D3_VITAMIN_B12_DEFICIENCY_ANEMIA_DUE_TO_INTRINSIC_FACTOR_DEFICIENCY

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D51.0
  • Cause of death: ICD-10 — D51.0

2 out of 7 registries used, show all original rules.

778

4. Check minimum number of events

None

778

5. Include endpoints

None

778

6. Filter based on genotype QC (FinnGen only)

685

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 685 362 323
Unadjusted period prevalence (%) 0.14 0.13 0.15
Median age at first event (years) 67.59 65.86 69.53

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
712
Matched controls
7120
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
107
Kela drug reimbursment
Pernicious anaemia
152.2
307.7
426
69
K29.4
ICD-10 Finland
Chronic atrophic gastritis
69.3
307.7
300
74
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
4503599627370496.0
307.7
711
5
B81
ICPC
Anaemia vit B12/folate deficiency
82.5
307.7
452
147
B03BA03
ATC
hydroxocobalamin; parenteral
259.5
307.7
647
263
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
59.1
262.9
150
32
WVA30, ,
SPAT
10.1
136.4
177
225
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
6.2
128.5
450
1545
T91
ICPC
Vitamin/nutritional deficiency
24.9
97.3
70
31
D51
ICD-10 Finland
Vitamin B12deficiency anaemia
43.3
92.9
56
14
B03BA02
ATC
cyanocobalamin tannin complex; parenteral
30.4
76.5
51
18
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.4
49.9
145
389
D64.9
ICD-10 Finland
Anaemia, unspecified
3.8
48.8
188
617
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.8
47.2
180
586
A55
ICPC
General and Unspecified, Local injection/infiltration
15.3
47.1
42
29
H03AA01
ATC
levothyroxine sodium; systemic
3.2
46.2
266
1119
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
10.3
44.4
51
53
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.9
42.5
395
2139
-50
ICPC
Medication/prescr/renewal
5.4
36.5
77
157
104
Kela drug reimbursment
Thyroid insufficiency
4.1
35.7
109
300
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
8.9
27.7
35
41
A50
ICPC
General and Unspecified, Medication/prescr/renewal
5.3
27.7
58
117
E53.8
ICD-10 Finland
Deficiency of other specified B group vitamins
27.4
25.1
34
13
UJD02
NOMESCO Finland
Gastroscopy
3.9
22.5
71
198
D51.8
ICD-10 Finland
Other vitamin B12deficiency anaemias
43.0
20.6
25
6
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
5.2
20.4
43
87
SPAT1254
SPAT
Administration of medicine
2.4
19.5
158
750
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.2
18.1
49
122
UJF32
NOMESCO Finland
Coloscopy
2.1
17.8
236
1364
A10AB05
ATC
insulin aspart; parenteral
3.0
17.7
84
303
B50
ICPC
Blood and Immunity, Medication/prescr/renewal
16.5
17.1
27
17
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
6.8
17.1
27
41
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
41.1
16.4
20
5
WVA20, ,
SPAT
4.0
16.1
47
124
UJF30
NOMESCO Finland
Ileoscopy through colon
2.6
15.7
96
396
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
15.0
123
582
JDA05
NOMESCO Finland
Endoscopic polypectomy in stomach or pylorus
25.7
14.7
20
8
-55
ICPC
Local injection/infiltration
11.2
14.1
26
24
T89
ICPC
Diabetes insulin dependent
4.0
13.8
40
105
B82
ICPC
Anaemia other/unspecified
3.7
13.7
45
129
ZX114, ,
SPAT
6.0
13.6
24
41
A10AE04
ATC
insulin glargine; parenteral
2.5
13.5
94
412
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.1
13.2
28
57
S50
ICPC
Skin, Medication/prescr/renewal
12.7
12.2
21
17
E10
ICD-10 Finland
Type 1 diabetes mellitus
9.5
12.1
24
26
B80
ICPC
Iron deficiency anaemia
4.1
12.0
33
83
D50.8
ICD-10 Finland
Other iron deficiency anaemias
5.5
11.9
23
43
A10AE05
ATC
insulin detemir; parenteral
2.9
11.7
55
197
B03BA01
ATC
cyanocobalamin; nasal, systemic
44.0
10.9
13
*
B81
ICD-10 Finland
Other intestinal helminthiases, not elsewhere classified
111.6
10.4
11
*
A10AB04
ATC
insulin lispro; parenteral
3.9
10.0
29
76
A10AA01, ,
ATC
4.1
9.8
27
68
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
9.5
130
740
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
101.3
9.4
10
*
R53
ICD-10 Finland
Malaise and fatigue
1.7
9.4
207
1363
A10AC01
ATC
insulin (human); parenteral
2.3
9.0
74
349
S55
ICPC
Skin, Local injection/infiltration
24.4
8.9
12
5
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.0
8.7
39
136
T50
ICPC
Metabolic, Medication/prescr/renewal
50.6
8.7
10
*
E61.1
ICD-10 Finland
Iron deficiency
4.6
8.6
20
44
2810X
ICD-9 Finland
Other deficiency anaemias, Pernicious anaemia[ANAEMIA PERNICIOSA SINE MYELOPATHIA SPINALI]
27.9
8.5
11
*
D50
ICPC
Digestive, Medication/prescr/renewal
91.1
8.4
9
*
8240/3-C16.9
ICD-O-3
Neuroendocrine tumor, NOS, of stomach, NOS
91.1
8.4
9
*
SPAT1262
SPAT
Handing over of treatment supplies
1.8
8.4
137
824
T86
ICPC
Hypothyroidism/myxoedema
2.9
8.2
39
141
R50.9
ICD-10 Finland
Fever, unspecified
1.9
7.9
115
668
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.2
7.9
68
327
D37.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Stomach
8.6
7.8
16
19
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
7.8
126
754
A04
ICPC
Weakness/tiredness general
1.8
7.8
129
779
A10AE06
ATC
insulin degludec; parenteral
3.2
7.6
29
92
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
7.2
7.5
17
24
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
7.4
285
2136
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.2
7.2
63
305
XW000
NOMESCO Finland
Bone marrow biopsy
2.7
7.1
39
152
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
7.1
104
603
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.2
7.1
59
279
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
7.1
156
1018
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.1
7.0
68
342
UJF92
NOMESCO Finland
Capsular endoscopy
4.0
6.9
19
48
A29
ICPC
General symptom/complaint other
1.8
6.8
116
706
E53.9
ICD-10 Finland
Vitamin B deficiency, unspecified
22.8
6.7
9
*
E03
ICD-10 Finland
Other hypothyroidism
2.3
6.7
49
220
A28
ICPC
Limited function/disability NOS
1.6
6.7
178
1219
A10AB01
ATC
insulin (human); parenteral
2.9
6.7
31
111
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.2
6.5
56
269
A10AA02, ,
ATC
2.7
6.5
35
136
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
6.5
175
1202
376
Kela drug reimbursment
Cyanocobalamin
70.5
6.4
7
*
H02AB09
ATC
hydrocortisone; systemic
3.5
6.3
21
61
D07AC13
ATC
mometasone; topical
1.6
6.3
191
1345
S97
ICPC
Chronic ulcer skin
2.1
6.3
63
321
177
Kela drug reimbursment
Insulin glargine 300 U / ml
3.9
6.3
18
47
D51.1
ICD-10 Finland
Vitamin B12deficiency anaemia due to selective vitamin B12malabsorption with proteinuria
+∞
6.3
6
*
SPAT1100
SPAT
Long-term monitoring of blood pressure
2.0
6.2
64
329
H3600, E103,
ICD-10 Finland
8.7
6.1
12
14
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
10.1
6.0
11
11

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
208
822
3.16
39.30
1.6
1.2
—
—
—
0
0
323
1801
2.45
29.58
3.1
2.4
3.33
3.09
mg/l
0.99
287
1534
252
1324
2.40
25.57
2.2
1.8
1121.42
1209.03
nmol/l
0.67
192
996
441
2967
2.28
24.43
3.4
2.3
85.13
94.54
pmol/l
2.84
271
1542
173
876
2.29
18.26
3.5
2.4
1.92
1.79
%
0.56
147
788
213
1185
2.14
17.74
3.7
2.6
10.94
12.01
umol/l
1.53
204
1107
200
1107
2.12
16.74
3.3
2.6
2.30
2.25
g/l
0.52
189
1030
376
2670
1.87
14.73
4.8
3.1
152.28
133.40
ug/l
0.21
354
2460
236
1460
1.92
14.07
2.3
1.8
943.35
23103312.93
pmol/l
1.18
192
1186
181
1032
2.01
13.63
3.4
2.6
20.12
21.45
%
0.61
170
966
181
1059
1.95
12.53
1.5
1.5
2.48
2.64
g/l
0.42
96
608
196
1178
1.92
12.53
1.4
1.3
0.79
1.32
u/ml
1.34
41
301
77
345
2.38
10.50
2.1
1.8
1.46
1.58
g/l
0.52
54
311
123
676
1.99
10.02
3.2
2.6
73.81
68.64
e9/l
0.84
103
515
280
1995
1.67
9.51
4.8
4.4
—
—
—
0
0
419
3336
1.62
8.89
7.8
6.6
12.34
11.92
umol/l
0.25
392
3177
390
3053
1.61
8.86
7.8
6.6
1.21
1.21
mmol/l
0.07
358
2794
89
459
2.07
8.60
4.4
3.7
5.13
5.16
kpa
0.10
84
439
421
3371
1.61
8.60
10.3
9.2
4.27
4.21
e9/l
0.09
367
2905
88
452
2.08
8.59
4.3
3.7
7.41
7.42
ph
0.38
70
376
112
629
1.93
8.51
2.1
3.0
66.80
66.22
g/l
0.32
98
574
361
2793
1.59
8.47
8.0
5.7
3.21
2.84
%
1.51
339
2601
360
2792
1.59
8.30
8.0
5.8
0.66
0.67
%
0.06
337
2597
360
2797
1.58
8.20
8.2
5.8
8.91
9.08
%
0.53
338
2606
363
2830
1.58
8.12
8.2
5.8
25.85
26.03
%
0.09
343
2670
357
2782
1.57
7.94
7.9
5.7
58.20
58.53
%
0.17
338
2643
282
2083
1.59
7.90
2.1
1.8
18.78
20.42
nmol/l
1.27
253
1735
378
2987
1.57
7.88
6.5
5.0
33.94
34.80
g/l
2.14
357
2775
352
2742
1.56
7.79
3.1
2.4
76.99
79.35
nmol/l
0.89
317
2426
267
1958
1.58
7.66
3.3
2.6
65.33
62.18
u/l
0.24
247
1811
380
3019
1.55
7.65
7.7
5.7
0.04
0.04
e9/l
0.44
327
2547
378
3004
1.55
7.56
7.7
5.7
0.60
0.61
e9/l
0.12
326
2530
383
3054
1.55
7.54
7.7
5.7
1.68
1.86
e9/l
2.57
343
2653
108
629
1.85
7.30
6.0
4.6
7.39
7.36
ph
2.80
80
444
272
2037
1.54
6.96
4.0
2.6
—
—
—
0
0
64
316
2.13
6.93
4.9
3.9
—
—
—
0
0
385
3111
1.52
6.87
7.7
5.8
0.22
0.19
e9/l
0.95
341
2676
90
508
1.88
6.70
1.6
1.5
—
—
—
0
0
410
3375
1.51
6.57
9.2
7.4
1.21
1.21
mmol/l
0.20
364
2909
272
2057
1.52
6.56
7.6
5.5
—
—
—
0
0
76
410
1.96
6.47
1.3
1.2
—
—
—
0
0
101
608
1.77
6.10
8.3
6.9
11.77
10.97
mmol/l
0.39
95
577
524
4583
1.54
5.99
10.6
8.5
97.80
81.52
u/l
2.57
494
4312
216
1590
1.51
5.78
3.4
2.9
359.45
352.30
umol/l
0.36
187
1366
26
93
2.86
5.62
1.3
1.3
—
—
—
0
0
135
900
1.62
5.56
7.0
5.4
1.05
1.04
mmol/l
0.26
124
824
102
632
1.72
5.56
2.8
2.1
216.55
140.51
ug/g
1.76
87
490
270
2100
1.46
5.42
4.3
3.3
6.74
7.09
mmol/l
0.79
237
1738
106
675
1.67
5.22
1.5
1.3
—
—
—
0
0
101
640
1.67
5.07
2.6
2.3
0.19
0.20
g/l
1.71
92
597
206
1537
1.48
5.06
3.0
2.6
—
—
—
0
0
93
579
1.70
4.98
2.3
1.8
359.57
390.21
nmol/l
0.90
87
532
431
3700
1.42
4.82
6.9
5.2
7.21
6.76
mmol/l
2.58
414
3541
86
530
1.71
4.78
2.0
2.7
—
—
—
0
0
269
2130
1.42
4.76
5.1
4.0
9.94
9.07
mg/mmol
0.13
180
1318
338
2801
1.39
4.54
3.8
2.9
—
—
estimate
—
0
0
25
99
2.58
4.51
3.0
1.2
0.56
0.88
nmol/l
1.39
20
82
260
2068
1.41
4.41
4.4
3.4
44.40
47.52
mg/l
0.11
181
1327
126
1757
0.66
4.40
3.7
3.5
—
—
—
0
0
108
721
1.59
4.39
3.3
2.7
5.75
8.05
umol/l
2.68
93
638
99
649
1.61
4.34
2.0
1.6
—
—
—
0
0
28
120
2.39
4.30
1.2
1.2
—
—
—
0
0
40
200
2.06
4.26
1.7
1.4
304.52
282.88
ug/g
0.25
23
124
109
735
1.57
4.25
1.7
1.5
—
—
—
0
0
112
764
1.55
4.15
1.6
1.3
742.86
453.79
titre
0.60
28
177
91
592
1.62
4.12
1.6
1.5
—
—
—
0
0
74
462
1.67
3.94
4.1
2.6
11.91
10.94
g/l
0.47
64
418
132
944
1.49
3.92
2.4
2.0
—
—
—
0
0
14
38
3.74
3.81
1.2
1.1
—
—
—
0
0
460
4073
1.37
3.79
6.6
5.4
8771.71
2514.49
e6/l
—
7
81
152
1126
1.44
3.76
3.2
3.1
0.80
0.82
mmol/l
0.81
146
1058
271
2217
1.36
3.74
3.9
3.6
—
—
—
0
0
61
368
1.72
3.69
1.8
1.7
1.77
1.39
g/l
0.43
51
333
14
45
3.15
3.66
1.3
1.7
—
—
—
0
0
52
301
1.78
3.63
1.3
1.2
318.04
128.09
u/ml
1.28
20
115
482
4317
1.36
3.58
6.5
4.3
15.35
15.05
pmol/l
1.61
443
3885
57
341
1.73
3.56
2.6
2.5
—
—
—
0
0
93
634
1.54
3.46
8.2
7.0
1.34
1.35
mmol/l
0.02
87
622
30
147
2.09
3.41
1.3
1.3
58.72
62.74
mmol/l
0.25
25
124
30
150
2.04
3.24
1.5
2.7
31.09
33.12
umol/l
0.25
23
126
144
1084
1.41
3.24
3.7
3.2
2.56
2.45
e6/l
0.05
68
542
20
85
2.39
3.17
1.3
1.1
200.85
313.34
u/ml
1.05
13
38
49
291
1.73
3.16
4.1
3.1
4.04
4.34
pmol/l
1.46
43
253
16
61
2.66
3.15
1.0
1.1
—
—
—
0
0
369
3221
1.30
3.05
19.3
18.1
1.38
1.34
inr
0.55
319
2722
19
81
2.38
3.01
1.3
1.3
135.18
171.20
au/ml
—
8
27
8
17
4.75
2.92
1.1
2.4
—
—
—
0
0
40
230
1.78
2.89
1.2
1.1
—
32.20
—
0
5
9
22
4.13
2.89
5.0
1.5
2.09
1.87
umol/l
—
9
17
586
5479
1.39
2.88
26.9
19.3
26.72
26.54
mg/l
0.05
518
4658
396
3506
1.29
2.87
4.1
3.3
59.06
53.82
u/l
0.26
363
3240
42
246
1.75
2.86
2.7
3.7
2.70
2.98
ratio
0.12
29
139
48
293
1.68
2.83
2.5
2.1
0.00
0.01
estimate
—
8
85
81
561
1.50
2.82
4.3
3.7
117.52
87.20
ng/l
1.50
68
481
11
34
3.27
2.73
2.7
1.5
11.22
23.70
umol/l
1.55
11
29
10
29
3.48
2.70
1.2
1.4
2.33
3.57
mmol/l
—
10
24
229
1905
1.30
2.63
3.6
3.1
40.13
32.93
u/l
0.83
215
1794
15
61
2.49
2.63
2.1
1.5
10.74
10.16
%
0.19
15
61
44
269
1.68
2.60
2.9
4.0
35.24
57.67
mg/l
0.83
38
227
44
269
1.68
2.60
2.9
4.0
77.45
78.03
mg/l
0.01
38
224
244
2051
1.29
2.58
4.5
4.2
7.40
7.40
ph
0.49
180
1500
31
172
1.84
2.54
1.6
1.7
—
—
—
0
0
16
69
2.35
2.50
2.4
2.6
—
—
—
0
0
120
916
1.37
2.48
1.3
1.3
13.78
13.09
u/ml
0.03
37
320
63
427
1.52
2.45
8.8
9.0
23.93
24.59
mmol/l
0.79
58
418
96
709
1.41
2.41
4.2
3.2
4.55
4.86
e9/l
0.23
77
601
102
762
1.40
2.40
3.5
4.2
7.97
28.31
ug/l
1.10
86
651
5
8
6.28
2.37
4.6
2.9
—
—
—
0
0
450
4107
1.26
2.30
6.3
5.0
—
2.51
—
0
9
29
164
1.80
2.26
1.2
1.2
—
880.00
—
0
5
28
157
1.82
2.24
1.3
2.3
19.58
13.06
mg/l
0.36
23
145
5
9
5.59
2.21
1.2
1.2
—
—
—
0
0
146
1169
1.31
2.20
3.4
3.0
0.78
1.22
e6/l
0.78
71
629
241
2057
1.26
2.19
2.4
2.2
159.50
241.91
u/l
1.21
228
1941
126
988
1.33
2.19
1.3
1.3
22.12
36.66
iu/ml
1.31
36
311
83
611
1.41
2.14
10.0
8.0
—
—
—
0
0
32
190
1.72
2.13
1.5
1.5
7.64
10.13
u/ml
—
5
28
598
5678
1.33
2.10
31.9
23.6
139.26
139.59
mmol/l
1.84
586
5563
110
851
1.35
2.10
7.7
7.6
0.40
1.14
mmol/l
1.11
90
695
23
124
1.88
2.09
1.7
1.6
—
—
—
0
0
9
31
2.93
2.08
1.0
1.0
—
—
—
0
0
252
2174
1.25
2.07
4.3
3.6
18.78
95.51
e6/l
1.86
184
1690
6
160
0.37
2.04
1.0
1.4
—
—
—
0
0
598
5685
1.32
2.03
32.4
23.8
4.00
4.00
mmol/l
0.15
585
5564
8
26
3.10
2.02
1.0
1.0
—
—
—
0
0
162
1335
1.28
1.96
5.1
4.5
501.47
243.69
ng/l
0.57
136
1141
14
64
2.21
1.95
4.1
4.6
—
—
—
0
0
109
856
1.32
1.89
7.8
7.6
4.88
5.07
kpa
1.35
101
823
12
52
2.33
1.88
1.8
1.5
84.00
412.86
titre
—
5
7
49
335
1.50
1.87
1.4
1.3
—
—
—
0
0
80
601
1.37
1.85
2.4
2.1
0.00
0.03
estimate
0.50
11
104
13
59
2.23
1.85
1.5
1.4
147.92
28.88
ng/l
0.69
13
59
108
851
1.32
1.83
7.9
7.7
7.41
7.42
ph
0.51
55
514
79
594
1.37
1.82
3.2
2.4
32.11
33.68
u/l
0.21
65
498
16
80
2.02
1.81
2.8
5.4
306.55
344.81
umol/l
0.42
11
72
7
23
3.06
1.80
3.4
3.3
840.57
742.52
u/ml
—
7
23
72
535
1.38
1.78
4.6
4.0
1.88
0.91
%
1.16
36
187
49
339
1.48
1.78
2.5
2.6
8.75
23.01
au/ml
—
6
23
203
1736
1.24
1.77
3.9
3.4
—
0.00
estimate
—
0
11
28
170
1.67
1.76
2.3
2.2
129.91
126.55
g/l
0.29
22
134
26
155
1.70
1.75
1.7
1.2
4.88
2.60
u/ml
—
5
20
108
857
1.31
1.74
7.9
7.6
10.81
11.64
kpa
1.82
101
825
8
30
2.69
1.72
2.5
3.3
—
—
—
0
0
160
1339
1.25
1.69
3.3
3.1
509.63
532.88
mosm/kgh2o
0.80
143
1165
268
2371
1.21
1.66
3.3
3.3
2080.18
1751.88
ng/l
0.55
239
2057
16
83
1.95
1.65
1.0
1.1
—
—
—
0
0
15
76
1.99
1.65
1.5
1.2
—
—
—
0
0
10
41
2.46
1.65
1.3
1.7
11.09
13.93
umol/l
—
10
36
95
748
1.31
1.63
6.4
3.4
7.39
7.38
ph
0.28
52
448
35
230
1.55
1.63
3.4
2.9
235.07
262.17
mg/l
0.13
15
90
5
14
3.59
1.62
3.4
1.5
28.00
31.07
%
—
5
14
42
288
1.49
1.61
1.3
1.3
—
—
—
0
0
354
3221
1.20
1.61
4.5
4.4
16.95
0.46
estimate
0.48
59
659
26
159
1.66
1.61
2.4
2.5
57.81
90.97
ug/min
0.45
15
94
10
43
2.34
1.59
1.4
1.8
79.00
87.10
ng/l
—
10
43
7
26
2.71
1.58
1.4
1.8
318.00
305.00
mu/l
—
7
17
271
2410
1.20
1.58
5.5
4.2
184.00
152.42
e6/l
0.13
187
1744
13
64
2.05
1.55
1.1
1.2
—
—
—
0
0
8
33
2.44
1.54
2.5
3.1
—
—
—
0
0
8
33
2.44
1.54
1.8
1.1
5.03
6.45
u/l
—
8
27
13
65
2.02
1.49
1.1
1.2
—
—
—
0
0
13
65
2.02
1.49
1.1
1.2
—
—
—
0
0
10
45
2.24
1.47
1.1
1.2
—
—
—
0
0
258
2298
1.19
1.45
2.4
2.3
—
—
—
0
0
15
80
1.89
1.45
1.5
1.3
4791.88
116818.61
e6/l
—
8
46
94
752
1.29
1.45
2.6
1.7
—
—
—
0
0
29
188
1.57
1.45
1.3
1.2
—
—
—
0
0
349
3192
1.18
1.45
4.6
4.4
0.00
5.03
estimate
0.80
67
697
291
2621
1.19
1.44
5.0
4.3
40.62
96.89
ng/l
1.03
236
2044
346
3163
1.18
1.44
4.6
4.4
0.00
0.00
estimate
-0.00
64
668
17
95
1.81
1.44
1.4
1.3
1087.42
1396.03
e6/l
0.25
12
68
19
110
1.75
1.44
2.7
2.2
0.82
0.86
%
0.15
13
78
11
53
2.09
1.39
1.1
1.2
—
—
—
0
0
9
41
2.21
1.37
1.1
1.1
—
—
—
0
0
538
5124
1.20
1.34
8.2
5.4
2.12
1.99
mu/l
1.25
491
4637
9
42
2.16
1.34
2.1
2.5
—
59.76
—
0
7
25
160
1.58
1.33
2.3
1.8
—
—
—
0
0
599
5769
1.24
1.32
34.5
25.8
88.76
82.16
umol/l
2.21
586
5683
65
502
1.32
1.31
4.4
4.1
0.17
0.12
%
0.28
29
155
65
502
1.32
1.31
4.9
4.1
1.00
0.56
%
1.62
35
168
6
24
2.51
1.30
1.7
1.5
—
—
—
0
0
42
302
1.42
1.30
2.2
2.0
—
—
—
0
0
5
18
2.79
1.28
1.2
1.0
2161.40
1514.11
miu/ml
—
5
18
5
18
2.79
1.28
1.6
1.8
—
—
—
0
0
12
62
1.95
1.28
1.1
1.2
—
—
—
0
0
9
44
2.06
1.27
1.1
1.1
98.33
95.89
pmol/l
—
9
44
20
123
1.64
1.25
1.2
1.2
—
—
—
0
0
282
2560
1.17
1.23
4.0
3.9
6.26
6.28
ph
0.10
154
1426
12
63
1.92
1.23
1.2
1.2
—
—
—
0
0
39
280
1.42
1.23
1.3
1.3
—
—
—
0
0
258
2328
1.17
1.21
3.9
3.6
2.35
2.36
mmol/l
0.09
234
2087
22
140
1.59
1.21
1.1
1.1
—
—
—
0
0
91
746
1.25
1.18
6.3
3.3
5.63
5.78
kpa
0.72
86
721
8
39
2.06
1.15
1.1
1.2
—
—
—
0
0
22
143
1.56
1.12
3.8
4.2
—
—
—
0
0
12
66
1.83
1.09
1.1
1.2
—
—
—
0
0
8
41
1.96
1.09
1.3
1.5
—
—
—
0
0
589
5694
1.20
1.06
16.1
12.9
23.85
24.25
u/l
0.19
565
5496
208
1869
1.16
1.02
4.0
3.5
0.24
0.55
e6/l
3.10
145
1400
33
240
1.39
1.00
3.2
1.6
12.03
8.31
iu/ml
—
10
62
7
35
2.01
1.00
1.0
1.3
—
—
—
0
0
39
292
1.36
1.00
2.5
3.4
70.61
5118.52
u/ml
0.87
34
254
13
76
1.72
0.99
1.2
1.3
0.68
24.55
nmol/l
0.49
13
71
9
49
1.85
0.99
1.1
1.0
—
—
—
0
0
14
84
1.68
0.98
1.2
1.4
—
—
—
0
0
7
36
1.95
0.97
1.6
1.5
28.66
34.29
u/l
—
7
31
14
85
1.66
0.95
1.0
1.0
—
—
—
0
0
86
720
1.22
0.94
6.5
3.3
1.06
2.00
mmol/l
1.50
78
604
11
62
1.79
0.94
1.1
1.1
—
—
—
0
0
600
5825
1.19
0.94
40.4
28.9
91.24
91.71
fl
1.29
587
5741
600
5825
1.19
0.94
40.6
29.0
242.53
242.61
e9/l
0.01
582
5698
600
5826
1.19
0.93
41.4
29.5
38.14
39.45
%
7.64
587
5737
600
5826
1.19
0.93
40.6
29.0
6.97
6.85
e9/l
0.18
580
5684
600
5826
1.19
0.93
40.5
29.0
4.25
4.38
e12/l
5.89
580
5681
600
5826
1.19
0.93
40.4
28.9
30.04
30.39
pg
3.67
587
5741
600
5827
1.19
0.93
40.9
29.2
126.11
131.93
g/l
15.41
587
5742
13
78
1.68
0.92
1.4
1.3
—
—
—
0
0
19
128
1.50
0.86
3.9
1.7
3.42
53.16
iu/l
—
7
48
40
512
0.77
0.86
1.5
1.5
—
—
—
0
0
8
44
1.83
0.86
1.0
1.3
—
—
—
0
0
12
191
0.62
0.85
1.1
1.1
—
—
—
0
0
62
508
1.24
0.84
4.7
4.5
0.03
0.17
%
1.04
29
146
12
73
1.65
0.82
1.0
1.1
—
—
—
0
0
13
81
1.62
0.81
2.1
1.4
—
—
—
0
0
13
81
1.62
0.81
2.1
1.4
—
—
—
0
0
13
81
1.62
0.81
2.1
1.4
—
—
—
0
0
13
81
1.62
0.81
2.1
1.4
—
—
—
0
0
30
224
1.35
0.81
1.8
1.4
—
—
—
0
0
0
24
0.00
0.79
0.0
1.3
—
—
—
0
0
0
24
0.00
0.79
0.0
1.2
—
6.95
—
0
24
0
24
0.00
0.79
0.0
1.3
—
1.31
—
0
17
0
25
0.00
0.79
0.0
1.5
—
—
—
0
0
66
552
1.22
0.76
1.5
1.4
—
—
—
0
0
18
255
0.70
0.76
1.3
1.4
—
—
—
0
0
149
1340
1.14
0.73
1.6
1.7
1.32
1.45
mg/l
0.31
120
1066
5
25
2.01
0.73
1.2
1.1
65.40
659.85
u/l
—
5
20
82
704
1.19
0.72
8.7
8.4
115.29
119.37
g/l
1.21
82
690
9
56
1.61
0.72
1.4
1.8
—
—
—
0
0
10
60
1.68
0.72
1.2
1.3
—
—
—
0
0
511
5274
0.89
0.70
5.7
5.2
1.39
1.47
mmol/l
3.30
478
4795
489
5055
0.90
0.68
4.8
4.5
1.29
1.25
mmol/l
0.65
451
4548
165
1504
1.13
0.66
4.2
4.2
—
0.23
—
0
22
47
387
1.23
0.65
11.7
10.2
15.52
15.58
%
0.06
47
373
15
104
1.45
0.63
1.1
1.3
232.33
255.09
miu/ml
—
6
42
198
1830
1.11
0.62
4.6
4.4
0.00
0.00
estimate
0.50
60
611
6
102
0.58
0.62
1.0
1.2
0.92
0.89
g/l
—
6
102
516
5308
0.90
0.61
5.7
5.4
4.26
4.48
mmol/l
5.49
489
4860
8
51
1.57
0.60
1.1
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
118.85
—
0
15
12
80
1.51
0.60
1.3
1.3
—
—
—
0
0
59
505
1.18
0.57
3.4
2.9
6.16
6.08
ph
0.25
41
354
537
5229
1.11
0.57
8.5
7.1
42.05
40.09
mmol/mol
4.07
503
4831
39
471
0.82
0.56
4.5
4.2
—
—
—
0
0
6
37
1.63
0.55
1.7
1.4
1.43
1.07
promille
—
6
32
6
37
1.63
0.55
2.0
1.6
0.67
3.89
u/field
—
6
25
23
177
1.31
0.55
4.0
3.6
4.50
1.78
index
—
10
96
132
1202
1.12
0.55
6.0
4.7
—
—
—
0
0
16
117
1.38
0.52
1.1
1.2
4.47
3.85
mmol/l
0.76
16
108
53
455
1.18
0.50
6.0
3.0
117.02
125.64
g/l
2.66
53
445
14
101
1.39
0.50
1.5
1.1
—
—
—
0
0
14
101
1.39
0.50
1.1
1.2
—
—
—
0
0
38
317
1.21
0.49
1.5
1.9
3.52
2.52
ug/l
0.22
33
275
566
5540
1.11
0.49
24.8
17.5
—
—
—
0
0
10
68
1.48
0.47
3.7
3.8
14.00
12.00
index
—
5
41
7
48
1.46
0.47
1.1
3.1
15.36
15.66
%
—
7
48
166
1545
1.10
0.46
3.4
2.8
4.47
5.34
e6/l
0.62
149
1411
54
469
1.16
0.46
5.4
5.1
—
—
—
0
0
190
1781
1.09
0.46
7.1
6.3
—
—
—
0
0
10
69
1.46
0.44
1.9
2.1
—
—
—
0
0
532
5434
0.92
0.44
6.7
6.2
2.43
2.56
mmol/l
3.07
499
4953
13
95
1.38
0.44
1.4
1.7
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
98.80
138.21
nmol/l
—
5
31
12
87
1.39
0.42
1.0
1.1
—
—
—
0
0
6
95
0.63
0.42
1.0
1.2
1.55
1.56
g/l
—
6
95
0
15
0.00
0.41
0.0
1.1
—
0.59
—
0
6
60
531
1.14
0.41
4.9
4.1
1.21
1.23
mmol/l
1.88
54
458
5
34
1.47
0.40
1.0
1.5
—
—
—
0
0
137
1471
0.91
0.40
1.3
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
142.16
—
0
18
25
205
1.23
0.39
3.9
3.5
0.92
0.83
nmol/l
0.53
18
172
154
1441
1.09
0.39
4.5
4.7
1.02
1.02
kg/l
0.44
106
993
9
66
1.37
0.38
1.2
1.3
—
—
nmol/l
—
0
0
9
68
1.33
0.37
2.1
2.4
—
—
—
0
0
6
46
1.31
0.33
1.7
1.3
—
—
—
0
0
20
165
1.22
0.31
9.9
12.5
—
—
—
0
0
27
230
1.18
0.31
1.2
1.2
—
—
—
0
0
29
336
0.86
0.31
7.7
3.2
24.83
25.04
mmol/l
0.13
29
326
11
84
1.31
0.30
2.7
1.2
151.59
67.86
mu/l
0.31
11
77
7
55
1.28
0.30
1.1
1.3
—
—
—
0
0
40
354
1.14
0.29
1.2
1.3
—
—
—
0
0
7
56
1.25
0.29
1.7
2.5
947.23
937.98
mg
—
7
56
18
148
1.22
0.29
1.3
1.2
—
—
—
0
0
7
57
1.23
0.29
1.1
1.2
—
—
—
0
0
22
186
1.19
0.28
1.6
1.4
0.43
0.27
mg/l
—
10
74
15
123
1.22
0.25
2.1
1.8
56.53
45.50
nmol/l
0.85
15
113
528
5356
0.95
0.25
6.2
5.6
6.21
6.05
mmol/l
1.63
484
4829
9
77
1.17
0.24
2.3
2.0
89.40
89.14
%
—
9
77
16
190
0.84
0.23
4.4
5.2
—
—
—
0
0
15
125
1.20
0.22
5.7
2.7
10.47
9.52
pmol/l
0.16
15
125
0
11
0.00
0.21
0.0
2.2
—
2.36
—
0
11
0
10
0.00
0.21
0.0
1.0
—
17.44
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
8
103
0.77
0.21
2.1
3.0
—
—
—
0
0
232
2389
0.96
0.20
4.8
4.5
8.96
0.05
estimate
0.49
56
553
0
14
0.00
0.20
0.0
1.5
—
8.28
—
0
14
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
6
49
1.23
0.20
3.7
2.5
—
—
—
0
0
6
49
1.23
0.20
1.3
1.3
7.45
7.39
ph
—
6
38
6
50
1.20
0.19
2.2
2.1
—
—
—
0
0
34
311
1.10
0.17
5.5
5.9
0.83
0.88
%
0.35
34
294
51
480
1.07
0.14
1.6
1.5
—
—
—
0
0
36
334
1.08
0.14
5.7
5.6
1.60
1.54
%
0.22
36
317
8
99
0.81
0.13
1.9
2.6
—
—
—
0
0
197
2016
0.97
0.13
5.9
6.2
4.42
2.91
ug/l
0.55
183
1783
13
147
0.88
0.11
1.1
1.1
—
—
—
0
0
5
61
0.82
0.08
2.0
1.0
—
—
—
0
0
5
62
0.81
0.08
2.0
1.0
—
—
—
0
0
7
65
1.08
0.08
1.3
1.1
—
—
—
0
0
148
1458
1.02
0.05
3.8
3.1
2.49
2.46
mmol/l
1.93
133
1307
29
302
0.96
0.04
1.3
1.4
—
—
—
0
0
10
91
1.10
0.04
3.7
2.7
4.50
4.56
e9/l
—
10
91
82
805
1.02
0.04
1.4
1.4
—
—
—
0
0
224
2253
0.99
0.02
2.0
1.9
1.27
1.28
mmol/l
0.09
192
1850
167
1658
1.01
0.02
4.3
4.0
4.90
0.06
estimate
0.48
51
525
257
2564
1.00
0.00
14.5
11.8
0.00
0.00
e9/l
0.05
197
2088
12
115
1.04
0.00
1.3
1.4
—
—
—
0
0
15
152
0.99
0.00
8.5
8.8
11.73
11.54
mmol/l
0.08
15
140
15
152
0.99
0.00
8.5
8.8
103.93
105.05
mmol/l
0.33
15
140
12
121
0.99
0.00
3.9
2.7
61.25
59.84
%
0.11
12
121
63
628
1.00
0.00
2.3
2.5
7.20
6.33
ug/l
0.17
44
541
62
621
1.00
0.00
4.1
3.3
361.02
251.98
ng/l
0.48
53
575
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
-0.00
1.0
1.1
—
—
—
0
0
5
55
0.91
-0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
117
1170
1.00
-0.00
3.5
3.4
0.81
0.81
ug/l
0.01
91
809
0
8
0.00
-0.00
0.0
1.1
—
31.60
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
50
1.00
-0.00
1.4
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
7.67
—
0
5
5
53
0.94
-0.00
1.2
2.9
9.34
7.55
mmol/l
—
5
53
29
290
1.00
-0.00
1.9
2.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
0.54
—
0
7
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
1.90
—
0
7
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
68.57
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: D3_VITAMIN_B12_DEFICIENCY_ANEMIA_DUE_TO_INTRINSIC_FACTOR_DEFICIENCY – Vitamin B12 deficiency anemia due to intrinsic factor deficiency

GWS hits: 1

This endpoint is excluded (different definition than used in FinnGen).