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Other and unspecified aplastic anaemias

DOID EFO Endpoint Browser PheWeb

D3_OTHERAPLASTICANAEMIA

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D61
  • Hospital discharge: ICD-9 — 2848
  • Hospital discharge: ICD-8 — 284
  • Hospital discharge: excluded ICD-9 — 2848C
  • Hospital discharge: excluded ICD-8 — 28404
  • Cause of death: ICD-10 — D61
  • Cause of death: ICD-9 — 2848
  • Cause of death: ICD-8 — 284
  • Cause of death: excluded ICD-9 — 2848C
  • Cause of death: excluded ICD-8 — 28404
  • KELA reimbursements: KELA codes — 122

3 out of 7 registries used, show all original rules.

547

4. Check minimum number of events

None

547

5. Include endpoints

None

547

6. Filter based on genotype QC (FinnGen only)

410

Control definitions (FinnGen only)

Control exclude
D3_APLASTICANDOTHANAEMIA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D60-D64
Name in latin
Aliae anaemia aplasticae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4109 2037 1985
Only index persons 2722 1371 1351
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.06
Only index persons 0.05 0.05 0.05
Median age at first event (years)
Whole population 64.32 65.00 63.49
Only index persons 61.52 61.81 61.22

-FinnGen-

Key figures

All Female Male
Number of individuals 410 193 217
Unadjusted period prevalence (%) 0.08 0.07 0.10
Median age at first event (years) 61.90 55.27 67.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
437
Matched controls
4370
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D64.9
ICD-10 Finland
Anaemia, unspecified
34.7
255.6
182
88
XW000
NOMESCO Finland
Bone marrow biopsy
41.5
251.7
165
63
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
+∞
225.1
196
*
L04AD01
ATC
ciclosporin; systemic
74.0
178.9
98
17
WW500
NOMESCO Finland
Blood transfusion
22.3
148.9
120
73
122
Kela drug reimbursment
Aplastic anaemia
+∞
131.0
119
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
37.2
127.9
82
27
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
51.4
106.1
62
14
D70.89
ICD-10 Finland
Neutropenic splenomegaly
44.4
96.0
58
15
D61.0
ICD-10 Finland
Constitutional aplastic anaemia
+∞
81.9
76
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
11.0
76.9
91
102
D61.3
ICD-10 Finland
Idiopathic aplastic anaemia
+∞
69.7
65
*
D61.1
ICD-10 Finland
Drug-induced aplastic anaemia
+∞
64.2
60
*
L03AA02
ATC
filgrastim; parenteral
13.2
63.4
64
56
B03XA02
ATC
darbepoetin alfa; parenteral
17.1
49.2
42
27
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.8
46.2
132
359
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
11.3
42.9
47
46
D61.8
ICD-10 Finland
Other specified aplastic anaemias
+∞
42.4
40
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.0
42.4
71
118
ZX120
NOMESCO Finland
Intravenous
5.4
42.3
97
218
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.3
31.0
182
785
D70.82
ICD-10 Finland
Drug-induced neutropenia
11.8
29.6
31
28
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
29.5
276
1541
L04AA01
ATC
[U] ciclosporin
27.6
28.0
38
15
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
103.3
27.0
29
*
B02BX05
ATC
eltrombopag; oral
99.5
26.0
28
*
H02AB06
ATC
prednisolone; systemic
2.9
25.9
263
1496
127
Kela drug reimbursment
Transplant complication
25.2
25.2
35
15
R50.9
ICD-10 Finland
Fever, unspecified
3.3
24.2
116
435
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.6
24.0
92
299
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
23.7
194
975
L04AX01
ATC
azathioprine; systemic
6.3
23.7
42
73
WW200
NOMESCO Finland
Immunization
8.0
23.7
33
44
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.1
22.9
120
472
H02AB09
ATC
hydrocortisone; systemic
8.3
22.8
31
40
J01MA12
ATC
levofloxacin; systemic
3.0
21.9
123
503
A04AA01
ATC
ondansetron; systemic, rectal
4.0
21.8
69
196
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
63.3
21.1
24
*
3039, ,
Kela drug reimbursment
80.9
20.9
23
*
1517, ,
Kela drug reimbursment
80.9
20.9
23
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.7
20.5
51
120
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
50.6
20.4
24
5
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
28.7
20.3
27
10
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.7
20.0
70
213
D64.8
ICD-10 Finland
Other specified anaemias
21.3
19.3
28
14
D61.2
ICD-10 Finland
Aplastic anaemia due to other external agents
+∞
18.9
18
*
JN4AD
NOMESCO Finland
Body CT examination
3.4
18.8
79
270
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.2
18.6
40
83
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
31.6
18.5
24
8
A41.9
ICD-10 Finland
Sepsis, unspecified
5.5
18.5
37
72
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
46.1
18.4
22
5
JN4BD
NOMESCO Finland
Extensive body CT
3.4
18.4
74
246
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.4
17.9
48
120
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
17.7
132
618
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
16.2
16.4
26
17
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.5
16.1
41
98
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
6.7
16.0
26
41
Z51.5
ICD-10 Finland
Palliative care
3.4
15.9
64
212
M04AA01
ATC
allopurinol; systemic
2.8
15.9
91
370
D60.9
ICD-10 Finland
Acquired pure red cell aplasia, unspecified
+∞
15.7
15
*
C03CA01
ATC
furosemide; systemic
2.3
15.6
182
1033
N02AA05
ATC
oxycodone; systemic
2.5
14.8
113
530
B82
ICPC
Anaemia other/unspecified
6.1
14.1
25
43
ZX108
NOMESCO Finland
Inhalation
20.9
13.9
20
10
B03BA03
ATC
hydroxocobalamin; parenteral
3.9
13.5
41
112
9989/3-C42.1
ICD-O-3
Myelodysplastic syndrome, NOS, of bone marrow
144.3
13.5
14
*
V03AC03
ATC
deferasirox; oral
144.3
13.5
14
*
L04AA06
ATC
mycophenolic acid; systemic
14.4
13.4
22
16
A05AA02
ATC
ursodeoxycholic acid; oral
11.5
13.2
24
22
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.7
13.1
44
129
A46
ICD-10 Finland
Erysipelas
2.6
13.0
88
387
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
13.0
69
268
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
5.6
12.9
25
47
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
10.5
12.6
24
24
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
5.2
12.3
26
53
TGC00
NOMESCO Finland
Bronchial lavation
4.8
12.3
28
61
A02BC02
ATC
pantoprazole; systemic
2.2
12.1
306
2270
Z31.5
ICD-10 Finland
Genetic counselling
3.8
12.1
39
111
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
9.0
11.7
24
28
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
10.5
11.6
22
22
UJF32
NOMESCO Finland
Coloscopy
2.2
11.6
128
696
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.1
11.6
33
86
J05AB01
ATC
aciclovir; systemic
2.2
11.1
109
565
L03AA13
ATC
pegfilgrastim; parenteral
3.8
10.9
34
95
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
10.7
145
850
B02AA02
ATC
tranexamic acid; systemic
2.6
10.5
67
285
175
Kela drug reimbursment
Deferasirox
+∞
10.5
10
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.8
10.4
56
218
H02AB02
ATC
dexamethasone; systemic
2.6
10.3
63
263
K92.1
ICD-10 Finland
Melaena
3.5
10.1
35
105
A03FA01
ATC
metoclopramide; systemic, rectal
2.1
9.9
110
596
9861/3-C42.1
ICD-O-3
Acute myeloid leukemia, NOS, of bone marrow
26.7
9.9
13
5
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.9
9.8
236
1670
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
5.0
9.6
21
44
J01MA14
ATC
moxifloxacin; systemic
2.7
9.5
52
205
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
9.3
67
301
TK800
NOMESCO Finland
Hemodialysis
8.0
9.2
20
26
B03XA01
ATC
erythropoietin; parenteral
11.8
9.1
16
14
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
8.9
81
403
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.2
8.9
24
60
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.0
8.9
40
141
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
3.5
8.8
31
94
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
8.7
118
684
GD1AD
NOMESCO Finland
Thorax CT examination
3.0
8.6
39
138
Z3231
NOMESCO Finland
Registered nurse
1.9
8.6
134
814
SPAT1088
SPAT
Blood transfusion
28.1
8.5
11
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
6.9
8.5
20
30
A11CC03
ATC
alfacalcidol; systemic
5.0
8.4
18
37
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
13.1
8.4
14
11
D60.8
ICD-10 Finland
Other acquired pure red cell aplasias
+∞
8.4
8
*
28409
ICD-8 Finland
Aplastic anaemia, Unspecified
+∞
8.4
8
*
WX892
NOMESCO Finland
Monitored bed care
2.7
8.3
45
176
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.7
8.3
26
73
ZXD05
NOMESCO Finland
Urgent procedure
1.9
8.1
141
885
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
22.5
8.0
11
5
L04AD02
ATC
tacrolimus; systemic
13.4
7.9
13
10
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
11.1
7.8
14
13
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
11.1
7.8
14
13
D69.5
ICD-10 Finland
Secondary thrombocytopenia
45.8
7.7
9
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
3.4
7.7
28
87
AA1AD
NOMESCO Finland
CT of head and brain
1.8
7.7
140
891
J02AC03
ATC
voriconazole; systemic
25.5
7.6
10
*
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
25.5
7.6
10
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
10.3
7.6
14
14
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
6.7
7.5
18
28
JN3AD
NOMESCO Finland
Abdominal CT examination
2.2
7.5
66
324
D59.5
ICD-10 Finland
Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
81.4
7.4
8
*
28402
ICD-8 Finland
Aplastic anaemia, Acquisita secundaria
+∞
7.3
7
*
TPH07
NOMESCO Finland
Cathetrisation of artery
2.3
7.2
58
274
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.8
7.2
36
135
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
8.1
7.2
15
19
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
7.1
98
569
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
3.0
7.1
31
108
1XC02, ,
NOMESCO Finland
14.1
6.9
11
8
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.8
6.8
21
58
A07EC02
ATC
mesalazine; oral, rectal
3.1
6.8
29
99
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
6.8
83
461
C95.0
ICD-10 Finland
Acute leukaemia of unspecified cell type
40.7
6.8
8
*
D69.1
ICD-10 Finland
Qualitative platelet defects
40.7
6.8
8
*
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
40.7
6.8
8
*
J02AC04
ATC
posaconazole; systemic
40.7
6.8
8
*
3AC01, ,
NOMESCO Finland
17.0
6.8
10
6
H02AB07
ATC
prednisone; oral
2.1
6.7
67
345
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
4.1
6.7
18
45
XQ848
NOMESCO Finland
Dermatological photography
3.9
6.6
19
50
L01BB02
ATC
mercaptopurine; oral
8.9
6.6
13
15
C90.0
ICD-10 Finland
Multiple myeloma
7.0
6.6
15
22
N03AX16
ATC
[U] pregabalin
1.9
6.5
99
591
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
6.5
99
591
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
3.4
6.5
23
70
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.8
6.5
33
125
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
70.8
6.4
7
*
9961/3-C42.1
ICD-O-3
Primary myelofibrosis of bone marrow
70.8
6.4
7
*
9101
FHL
Bone biopsy
70.8
6.4
7
*
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
14.6
6.4
10
7
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
6.4
79
440
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
5.7
6.4
17
31
N02AX02
ATC
tramadol; systemic, rectal
1.7
6.3
184
1322
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
11.2
6.3
11
10
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
18.3
6.3
9
5
J05AB11
ATC
valaciclovir; oral
2.0
6.3
74
405
2848X
ICD-9 Finland
Aplastic anaemia, Other specified aplastic anaemias[ANAEMIA APLASTICA ACQUISITA NON DEFINITA]
+∞
6.3
6
*
2848D
ICD-9 Finland
Aplastic anaemia, Other specified aplastic anaemias[ANAEMIA APLASTICA ALIA DEFINITA]
+∞
6.3
6
*
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
6.3
6
*
306
Kela drug reimbursment
Erythropoietin and darbepoetin
27.1
6.2
8
*
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
27.1
6.2
8
*
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
27.1
6.2
8
*
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
27.1
6.2
8
*
R18
ICD-10 Finland
Ascites
5.9
6.2
16
28
J01FF01
ATC
clindamycin; systemic
1.8
6.2
118
755
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.7
6.1
19
53
A10AB05
ATC
insulin aspart; parenteral
2.4
6.1
41
179
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
10.2
6.1
11
11

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
120
30
54.76
204.22
1.7
1.1
—
—
—
0
0
115
37
41.82
182.51
2.0
1.2
—
—
—
0
0
125
53
32.63
181.41
2.7
1.8
—
—
—
0
0
154
130
17.75
161.83
2.7
1.7
1.22
1.43
g/l
1.24
131
118
241
426
11.38
149.49
12.6
2.5
1.94
1.70
%
2.26
230
384
206
326
11.06
138.62
12.8
2.4
63.37
67.65
e9/l
0.73
164
242
81
63
15.55
86.87
1.4
1.3
355.07
22.97
u/l
5.02
74
57
59
28
24.20
80.10
2.3
1.8
1008.57
1139.91
e6/l
0.29
46
23
45
11
45.49
75.09
1.2
1.3
—
—
—
0
0
147
296
6.98
75.09
4.2
2.6
10.44
10.38
g/l
0.05
140
275
69
67
12.04
63.98
1.5
1.3
—
—
—
0
0
66
65
11.78
60.54
1.4
1.4
281.58
253.55
u/ml
0.19
36
33
47
25
20.95
60.46
2.2
1.8
427.41
467.05
e6/l
0.16
34
19
63
58
12.52
60.40
1.7
1.3
133.65
144.93
au/ml
0.19
20
15
119
242
6.38
59.08
2.5
1.5
1.43
1.19
g/l
0.48
105
224
178
523
5.06
58.11
4.2
2.3
2.05
2.31
g/l
7.68
173
484
113
224
6.46
57.50
2.0
2.9
—
—
—
0
0
126
283
5.85
56.07
3.1
3.1
65.28
66.60
g/l
1.01
119
260
75
103
8.58
53.42
2.5
5.0
46.14
118.49
mg/l
0.63
62
85
74
103
8.45
52.08
2.5
5.0
34.88
33.13
mg/l
0.12
61
87
55
52
11.96
51.63
1.1
1.0
—
—
—
0
0
43
29
16.34
49.16
1.3
1.3
—
—
—
0
0
69
95
8.44
48.91
2.5
4.7
1.99
2.41
ratio
0.25
38
52
76
119
7.52
48.14
1.5
1.4
—
—
—
0
0
42
30
15.38
46.53
1.1
1.1
—
—
—
0
0
265
1210
4.02
44.96
25.5
6.0
—
—
—
0
0
111
268
5.21
44.77
1.6
1.4
—
—
—
0
0
177
617
4.14
44.39
9.0
3.5
0.78
0.82
mmol/l
4.45
169
590
224
940
3.84
42.49
3.2
2.1
2.95
2.85
mg/l
0.20
198
816
49
54
10.09
41.16
9.3
1.8
0.90
0.84
%
0.20
41
30
49
54
10.09
41.16
1.2
1.1
—
—
—
0
0
134
413
4.24
39.26
1.9
1.5
—
—
—
0
0
210
907
3.53
36.92
5.9
2.9
348.08
350.75
umol/l
0.11
197
794
151
560
3.59
33.16
1.9
1.6
—
—
—
0
0
102
292
4.25
32.52
1.8
1.4
—
—
—
0
0
316
1850
3.56
32.23
24.6
6.0
0.51
0.60
e9/l
6.13
292
1590
47
68
7.62
31.59
1.4
1.8
—
—
—
0
0
315
1859
3.49
31.31
24.7
6.0
0.03
0.04
e9/l
8.34
290
1598
124
423
3.70
30.67
6.8
3.3
12.03
8.05
umol/l
0.59
110
380
164
672
3.31
30.29
2.0
1.9
—
—
—
0
0
316
1893
3.42
30.11
24.9
6.1
2.02
2.00
e9/l
0.02
296
1672
39
48
8.82
29.95
10.2
1.9
35.44
33.44
pg
2.28
39
48
109
346
3.86
29.91
2.8
2.7
0.21
0.21
g/l
0.10
101
319
317
1920
3.37
29.28
27.4
6.3
0.13
0.19
e9/l
10.84
294
1675
317
1924
3.36
29.09
19.4
6.4
12.98
11.77
umol/l
0.95
312
1825
288
1669
3.13
28.35
6.6
2.8
418.68
119.50
ug/l
10.19
279
1540
152
617
3.24
28.23
2.1
1.7
1231.45
1160.68
nmol/l
0.36
131
465
100
314
3.83
27.72
11.7
4.4
1.03
0.96
%
0.10
75
104
218
1094
2.98
27.72
8.8
4.1
—
—
—
0
0
328
2070
3.34
27.36
39.4
9.4
3.11
4.19
e9/l
4.75
309
1796
278
1625
2.95
26.09
11.8
5.0
34.49
35.64
g/l
2.70
270
1522
32
39
8.77
24.68
5.8
4.0
—
—
—
0
0
91
294
3.65
23.96
11.7
4.3
0.68
0.54
%
0.32
69
91
223
1204
2.74
23.65
14.6
2.5
—
—
—
0
0
88
301
3.41
21.06
13.3
4.7
0.38
0.14
%
0.68
64
78
291
1861
2.69
20.98
17.5
7.1
1.20
1.21
mmol/l
1.04
258
1602
179
911
2.63
20.74
13.7
2.3
—
—
—
0
0
86
295
3.38
20.46
12.2
4.5
0.09
0.11
%
0.13
62
84
165
814
2.65
20.29
2.8
1.7
1.46
1.36
mg/l
0.21
133
632
205
1126
2.55
20.11
10.7
4.0
7.40
7.39
ph
0.21
160
806
25
7
37.75
20.05
1.0
1.0
—
—
—
0
0
27
11
26.05
19.77
2.4
2.2
0.13
0.30
e9/l
—
13
6
23
5
48.37
19.38
2.1
3.8
—
—
—
0
0
31
21
15.79
19.22
3.2
2.7
36.89
48.22
%
—
20
9
200
1105
2.49
19.13
2.7
1.7
19.20
20.75
nmol/l
0.87
184
913
268
1692
2.51
19.12
16.2
6.6
1.20
1.21
mmol/l
1.31
259
1545
34
60
6.06
18.81
2.8
1.3
—
—
—
0
0
34
60
6.06
18.81
2.8
1.3
—
—
—
0
0
34
60
6.06
18.81
2.8
1.3
—
—
—
0
0
34
60
6.06
18.81
2.8
1.3
—
—
—
0
0
265
1679
2.47
18.54
15.3
2.8
—
—
estimate
—
0
0
156
780
2.56
18.33
2.3
1.4
2.29
2.45
g/l
0.51
123
463
23
7
34.56
18.14
1.3
1.3
—
—
—
0
0
113
487
2.78
17.85
1.5
1.4
422.22
449.91
titre
0.06
18
113
105
453
2.73
16.43
6.9
3.0
4.66
5.49
e9/l
0.26
95
394
252
1616
2.32
16.38
3.4
2.1
89.93
95.34
pmol/l
1.03
175
849
263
1755
2.25
15.03
17.4
15.3
1.31
1.29
inr
0.07
233
1459
19
6
33.00
14.92
2.1
1.5
31.84
21.83
%
—
19
6
201
1207
2.23
14.88
6.3
3.3
31.77
32.09
u/l
0.06
188
1141
26
48
5.70
13.70
5.8
3.2
2.75
4.20
e9/l
1.80
26
48
21
15
14.64
12.88
2.2
3.7
1031.86
659.20
u/ml
0.53
21
15
97
452
2.47
12.70
2.3
1.6
—
—
—
0
0
243
1646
2.07
12.44
36.1
10.8
0.08
0.00
e9/l
0.51
217
1343
177
1068
2.10
12.38
5.8
3.2
0.46
0.52
e6/l
0.12
138
789
82
357
2.60
12.36
2.8
2.0
365.39
394.26
nmol/l
0.67
75
336
183
1121
2.09
12.27
25.6
6.0
—
—
—
0
0
32
79
4.29
12.07
1.3
1.2
—
—
—
0
0
296
2172
2.12
12.03
11.5
5.1
6.66
6.67
mmol/l
0.02
290
2054
37
106
3.72
11.41
1.4
1.3
254.89
329.64
ug/g
1.16
24
63
79
353
2.51
11.23
4.1
2.5
30.49
170.62
u/l
0.51
74
293
16
8
20.69
11.21
1.4
1.4
—
—
—
0
0
106
544
2.25
11.01
2.6
2.0
—
—
—
0
0
140
808
2.08
10.75
16.4
4.8
—
—
—
0
0
35
101
3.68
10.68
4.6
2.8
2.57
2.13
index
0.18
21
60
44
152
3.11
10.14
1.1
1.4
—
18.56
—
0
5
191
1251
1.94
10.11
5.9
3.3
105.84
62.73
e6/l
0.25
150
963
208
1416
1.89
9.67
7.2
4.0
53.99
71.86
e6/l
0.47
156
1004
28
75
3.92
9.48
8.4
2.8
48.77
57.41
%
1.46
28
75
340
2741
2.08
9.28
26.7
7.9
87.87
79.51
u/l
1.37
335
2581
19
38
5.18
9.17
1.2
1.1
—
—
—
0
0
87
442
2.21
9.13
9.7
8.2
-0.11
1.15
mmol/l
1.47
73
371
111
620
2.06
9.12
5.5
3.1
1.62
2.04
e6/l
0.36
62
315
33
102
3.42
9.09
1.1
1.2
—
—
—
0
0
73
351
2.30
8.72
18.1
8.1
—
—
—
0
0
86
443
2.17
8.70
9.7
8.3
7.43
7.41
ph
1.31
45
265
222
1580
1.82
8.65
4.0
2.5
74.28
76.91
nmol/l
0.75
209
1401
15
14
11.05
8.35
4.6
1.5
—
—
—
0
0
37
130
3.02
8.28
1.1
1.3
—
—
—
0
0
185
1265
1.80
8.07
6.0
3.2
2.33
2.35
mmol/l
1.18
176
1149
170
1149
1.78
7.61
4.3
2.7
54.30
65.45
u/l
1.15
164
1069
136
865
1.83
7.42
4.0
2.6
4.90
5.69
e6/l
0.31
128
786
15
18
8.59
7.37
1.1
1.1
—
—
—
0
0
118
720
1.88
7.33
2.0
1.8
433.51
29195070.19
pmol/l
0.74
105
596
299
2405
1.77
7.00
7.5
4.8
43.86
2813.23
e6/l
—
7
44
120
746
1.84
6.99
4.6
4.0
1770.01
256.29
ng/l
0.58
112
595
119
742
1.83
6.85
4.4
2.8
529.66
548.16
mosm/kgh2o
0.43
107
648
17
40
4.38
6.81
1.5
1.3
—
—
—
0
0
50
230
2.33
6.59
3.2
6.3
—
—
—
0
0
169
1182
1.70
6.47
4.1
3.2
2700.22
1362.95
ng/l
2.05
153
1002
22
66
3.46
6.36
1.4
1.9
0.65
0.80
g/l
0.27
14
59
31
115
2.83
6.32
1.2
1.3
109.14
305.45
miu/ml
—
7
51
9
5
18.33
6.29
3.8
2.0
—
—
—
0
0
166
1163
1.69
6.27
2.7
2.1
573.44
270.01
u/l
0.31
160
1099
82
470
1.92
6.08
2.5
1.5
—
—
—
0
0
14
23
6.25
5.73
6.1
2.2
0.36
0.87
index
2.18
14
23
74
421
1.91
5.59
12.6
3.8
7.35
7.38
ph
1.54
54
246
35
148
2.48
5.55
2.2
1.6
15.42
5.80
iu/ml
—
10
37
17
37
4.74
5.54
1.5
1.3
0.51
0.36
g/l
—
9
31
17
37
4.74
5.54
1.5
1.3
4.30
2.32
g/l
—
9
30
17
37
4.74
5.54
1.5
1.3
7.77
6.32
g/l
—
9
31
16
33
4.99
5.48
2.2
2.8
—
—
—
0
0
71
402
1.91
5.44
12.6
3.8
1.40
1.79
mmol/l
0.29
62
333
40
184
2.29
5.28
2.6
2.4
—
—
—
0
0
22
77
2.96
5.00
3.5
2.8
33.41
36.22
umol/l
0.21
17
69
143
1015
1.61
4.90
2.0
1.4
—
—
—
0
0
11
18
6.24
4.63
1.3
1.1
—
—
—
0
0
77
471
1.77
4.60
1.5
1.2
—
—
—
0
0
9
11
8.33
4.58
1.9
1.9
0.62
0.60
mmol/l
—
9
11
9
11
8.33
4.58
1.1
1.5
29.11
28.18
s
—
9
11
15
36
4.28
4.56
1.0
1.2
—
—
—
0
0
157
1157
1.56
4.52
4.9
3.2
—
—
—
0
0
75
460
1.76
4.43
4.2
2.4
265.36
117.37
ug/g
1.09
64
358
198
1541
1.52
4.41
5.7
3.5
6.33
6.21
ph
0.62
95
845
9
12
7.63
4.37
1.2
1.9
—
—
—
0
0
7
6
11.83
4.29
5.3
2.0
1.29
3.83
%
—
7
6
14
34
4.22
4.24
6.3
2.3
13.57
12.30
index
0.19
14
23
63
374
1.80
4.15
2.4
4.5
4.45
19.13
ug/l
0.71
50
312
15
47
3.27
4.09
2.9
2.2
—
—
—
0
0
8
10
8.12
4.07
2.4
1.1
—
—
—
0
0
53
302
1.86
3.98
3.3
3.3
300.59
192.01
ng/l
0.55
46
273
15
48
3.20
3.96
1.1
1.3
—
—
—
0
0
17
59
2.96
3.94
2.1
2.9
—
—
—
0
0
18
65
2.85
3.90
1.5
1.2
14.50
7.13
u/ml
—
6
30
89
1271
0.62
3.84
3.3
3.2
—
—
—
0
0
7
8
8.87
3.78
2.6
1.5
—
—
—
0
0
10
20
5.09
3.71
1.1
1.1
—
—
—
0
0
86
574
1.62
3.70
1.3
1.3
3.56
11.42
u/ml
1.53
24
220
109
770
1.55
3.69
4.4
3.0
2.46
2.45
mmol/l
0.19
101
698
9
16
5.72
3.67
1.9
1.9
—
—
—
0
0
233
1922
1.45
3.65
6.1
3.9
0.00
0.00
estimate
-0.00
46
404
7
9
7.88
3.57
2.0
1.7
—
—
—
0
0
235
1955
1.44
3.44
6.1
3.9
0.02
0.77
estimate
0.48
47
388
234
1946
1.44
3.43
6.1
3.9
25.23
4.52
estimate
0.37
48
416
64
404
1.68
3.41
1.7
1.3
—
—
—
0
0
183
1457
1.44
3.39
4.9
4.0
27.35
39.84
ng/l
1.70
150
1065
9
18
5.08
3.38
1.2
1.3
—
—
—
0
0
272
2335
1.44
3.29
5.1
3.4
70.73
48.09
u/l
1.41
266
2177
35
186
1.96
3.25
1.1
1.1
—
—
—
0
0
19
80
2.44
3.10
1.1
1.5
—
—
—
0
0
54
335
1.70
3.07
2.2
2.2
0.00
0.00
estimate
—
7
71
55
343
1.69
3.07
1.8
1.7
—
—
—
0
0
22
100
2.26
3.05
11.3
3.9
65.10
60.04
%
0.54
22
95
11
31
3.61
3.01
1.7
1.5
76.17
64.09
%
—
6
23
10
26
3.91
2.99
1.2
1.3
—
—
—
0
0
5
5
10.09
2.98
9.4
2.8
33.20
34.00
u/l
—
5
5
49
302
1.70
2.86
2.3
2.5
9.74
6.98
ug/l
0.42
43
266
12
39
3.13
2.79
3.9
3.3
—
—
—
0
0
36
205
1.82
2.75
13.8
5.0
—
—
—
0
0
6
183
0.32
2.74
1.0
1.1
—
—
—
0
0
20
92
2.23
2.71
1.5
1.2
—
—
—
0
0
10
30
3.39
2.62
1.3
3.0
347.60
787.73
mg
—
10
30
46
286
1.68
2.61
13.0
4.6
7.43
7.42
ph
0.75
38
237
7
15
4.72
2.60
5.9
7.3
28.93
40.87
%
—
7
15
8
20
4.05
2.58
3.6
2.4
—
—
—
0
0
10
32
3.17
2.45
6.5
6.1
9.21
11.22
%
—
10
32
87
638
1.45
2.41
1.3
1.3
53.76
31.69
iu/ml
0.51
31
197
5
8
6.31
2.38
3.0
1.8
—
—
—
0
0
7
17
4.17
2.37
1.1
1.1
—
—
—
0
0
10
34
2.99
2.29
1.7
1.1
—
—
—
0
0
12
47
2.60
2.29
1.7
2.2
11.50
10.53
mmol/l
0.37
12
47
12
262
0.44
2.14
1.2
1.4
—
—
—
0
0
25
140
1.83
2.05
4.6
3.4
175.64
219.70
mg/l
0.51
14
54
17
83
2.09
2.04
1.7
1.5
8583.44
14197.41
e6/l
—
9
58
25
141
1.82
2.01
2.7
2.6
—
—
—
0
0
7
21
3.37
1.97
1.6
1.5
12.86
25.14
umol/l
—
7
21
44
296
1.54
1.86
1.3
1.2
—
—
—
0
0
107
856
1.33
1.76
1.5
1.3
0.55
1.53
u/ml
2.33
20
229
292
2667
1.29
1.69
4.9
4.2
15.01
14.87
pmol/l
0.41
281
2401
14
69
2.06
1.66
8.6
3.4
2.69
2.66
mmol/l
—
9
43
32
206
1.60
1.65
5.6
3.5
4.65
4.57
pmol/l
0.14
25
184
36
239
1.55
1.63
1.7
1.3
912.13
364.81
u/ml
0.52
30
215
8
32
2.53
1.60
1.0
1.1
—
—
—
0
0
11
50
2.23
1.58
2.1
1.9
—
—
—
0
0
165
1417
1.26
1.57
2.9
2.1
—
—
—
0
0
34
227
1.54
1.52
1.3
1.2
—
—
—
0
0
10
45
2.25
1.47
1.2
1.4
20.30
29.21
ng/l
—
10
45
14
73
1.95
1.45
7.9
2.8
—
—
—
0
0
5
16
3.15
1.44
1.2
1.1
131.20
184.50
mmol/24h
—
5
16
303
3236
0.79
1.42
7.1
6.5
39.01
39.38
mmol/mol
0.31
285
3028
46
333
1.43
1.40
7.8
4.0
7.37
7.34
ph
0.60
38
226
28
183
1.57
1.38
2.0
1.3
—
—
—
0
0
9
41
2.22
1.37
2.2
1.8
91.93
90.62
%
—
9
41
9
42
2.17
1.34
3.2
3.1
1.72
3.09
nmol/l
—
9
42
11
54
2.06
1.34
1.8
1.4
—
—
—
0
0
24
362
0.64
1.30
1.8
1.7
—
—
—
0
0
8
34
2.38
1.29
1.1
1.1
—
—
—
0
0
12
63
1.93
1.24
2.3
1.4
—
—
—
0
0
122
1419
0.81
1.23
2.1
1.9
1.40
1.34
mmol/l
0.37
113
1193
5
19
2.65
1.22
2.8
1.7
29.60
73.92
ug/l
—
5
19
15
86
1.77
1.20
4.1
3.0
89.04
89.29
%
0.06
15
80
8
38
2.13
1.19
1.5
1.3
4.78
7.01
mmol/l
—
8
33
10
50
2.02
1.17
1.0
1.3
0.57
0.53
nmol/l
—
10
45
325
3421
0.80
1.16
5.5
5.8
2.48
2.63
mmol/l
2.63
310
3163
13
72
1.83
1.16
2.7
3.3
0.80
0.87
nmol/l
—
8
59
313
3306
0.81
1.15
5.7
5.1
6.04
5.97
mmol/l
0.38
292
3024
145
1272
1.21
1.07
4.2
3.3
6.87
7.81
mmol/l
1.70
128
1078
45
343
1.35
1.05
2.2
1.5
—
—
—
0
0
17
106
1.63
1.04
2.4
1.2
—
—
—
0
0
22
147
1.52
1.02
2.1
1.6
32.68
21.96
iu/l
0.52
13
121
7
134
0.51
1.00
1.3
1.1
—
—
—
0
0
6
27
2.24
0.94
1.0
1.2
82.83
109.85
pmol/l
—
6
27
310
2936
1.19
0.91
69.0
19.8
14.92
13.61
%
23.50
310
2909
320
3348
0.83
0.90
4.8
5.0
1.35
1.44
mmol/l
3.31
302
3090
24
170
1.44
0.87
1.8
1.5
0.33
0.31
mg/l
0.06
11
77
367
3787
0.81
0.86
81.9
24.2
3.76
4.50
e12/l
57.93
361
3710
367
3787
0.81
0.86
81.9
24.3
5.93
6.88
e9/l
3.80
361
3710
10
57
1.77
0.84
1.1
1.1
—
5.77
—
0
15
8
47
1.71
0.81
1.1
1.2
—
—
—
0
0
323
3362
0.85
0.76
5.0
5.1
4.32
4.52
mmol/l
3.03
310
3122
5
25
2.01
0.73
3.2
2.0
12.82
16.64
%
—
5
25
7
39
1.81
0.73
1.3
1.2
—
—
—
0
0
28
212
1.34
0.72
1.3
1.3
101.75
122.06
u/ml
—
8
93
5
27
1.86
0.68
1.6
1.5
320.20
332.52
mu/l
—
5
21
334
3214
1.17
0.68
6.0
5.2
2.06
1.95
mu/l
0.72
317
2940
13
86
1.53
0.66
2.7
1.3
159.66
250.92
pmol/l
0.29
13
81
5
30
1.67
0.61
1.2
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
8.8
—
0.65
—
0
20
0
20
0.00
0.60
0.0
15.0
—
1000.00
—
0
20
14
97
1.46
0.59
2.0
1.9
3.25
5.49
iu/l
—
5
37
309
3204
0.88
0.58
4.5
4.3
1.40
1.26
mmol/l
2.22
292
2933
6
35
1.72
0.58
1.5
1.3
—
—
—
0
0
12
81
1.50
0.57
3.0
2.1
29.57
163.56
ug/min
—
7
50
129
1177
1.14
0.57
4.3
3.4
124.45
53.19
mg/l
1.01
95
778
97
869
1.15
0.56
6.2
4.1
1.02
1.02
kg/l
2.20
70
588
6
39
1.55
0.53
1.3
1.4
—
—
—
0
0
6
99
0.60
0.52
1.3
1.8
128.00
203.08
pmol/l
—
6
93
6
40
1.51
0.52
1.0
1.1
—
—
—
0
0
35
290
1.22
0.49
5.4
3.4
—
—
—
0
0
53
459
1.18
0.48
1.8
1.3
—
—
—
0
0
15
111
1.36
0.47
2.7
1.7
11.46
8.59
u/l
—
10
89
119
1095
1.12
0.46
5.7
3.9
0.00
0.01
estimate
0.74
44
375
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
357
3495
1.12
0.37
53.9
16.1
23.08
24.90
mg/l
0.64
336
2912
5
37
1.36
0.37
1.0
1.1
—
—
—
0
0
9
71
1.27
0.36
1.4
1.7
—
—
—
0
0
6
41
1.47
0.36
1.2
1.6
—
—
—
0
0
6
41
1.47
0.36
1.0
1.3
—
—
nmol/l
—
0
0
129
1209
1.10
0.35
5.3
4.1
27.14
8.55
mg/mmol
1.02
93
759
9
122
0.73
0.35
1.3
1.8
68.89
40.47
nmol/l
—
9
116
84
775
1.10
0.32
2.9
3.3
0.89
0.82
ug/l
0.16
63
513
17
138
1.24
0.31
1.3
1.6
—
7.22
—
0
28
8
108
0.74
0.29
1.1
1.1
1.35
1.55
g/l
—
8
108
13
103
1.27
0.28
10.2
4.0
—
—
—
0
0
352
3577
0.92
0.27
36.9
14.1
—
—
—
0
0
5
40
1.25
0.22
1.6
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
38.40
—
0
6
0
12
0.00
0.21
0.0
1.0
—
81.82
—
0
12
17
146
1.17
0.19
1.3
1.5
—
—
—
0
0
5
69
0.72
0.17
3.2
2.3
7.28
7.95
pmol/l
—
5
69
8
71
1.13
0.16
2.1
1.6
—
—
—
0
0
9
78
1.16
0.15
1.2
1.2
—
—
—
0
0
11
95
1.16
0.11
1.7
2.0
—
—
—
0
0
6
54
1.11
0.09
1.0
1.1
—
—
—
0
0
6
55
1.09
0.09
1.0
1.1
—
—
—
0
0
6
56
1.07
0.08
1.2
1.1
—
21.09
—
0
11
149
1463
1.03
0.08
6.6
3.8
0.00
0.04
estimate
1.63
39
344
7
83
0.84
0.07
1.0
1.1
—
—
—
0
0
11
122
0.90
0.07
1.2
1.6
260.18
339.25
mu/l
0.90
11
112
129
1313
0.98
0.06
5.3
5.6
3.48
2.99
ug/l
0.14
116
1169
12
132
0.91
0.06
1.5
1.7
—
—
—
0
0
17
159
1.07
0.05
1.4
1.5
—
—
—
0
0
17
160
1.07
0.04
1.4
1.5
—
—
—
0
0
17
161
1.06
0.03
1.4
1.5
—
—
—
0
0
10
108
0.92
0.03
18.0
9.7
—
—
—
0
0
106
1072
0.99
0.02
6.1
3.2
0.08
0.09
estimate
0.05
38
323
16
168
0.95
0.02
2.5
1.9
—
—
—
0
0
38
372
1.02
0.01
1.3
1.6
—
—
—
0
0
13
124
1.05
0.00
1.4
1.6
—
—
—
0
0
17
174
0.98
0.00
1.3
1.3
—
—
—
0
0
16
163
0.98
0.00
1.4
1.5
—
—
—
0
0
11
112
0.98
0.00
1.5
1.1
0.80
0.87
g/l
0.66
11
112
11
111
0.99
0.00
1.6
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.3
—
6.66
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
79
1.01
-0.00
1.4
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
68.57
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
14.90
—
0
7
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
92.16
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint D3_OTHERAPLASTICANAEMIA and mortality.

Females

Parameter HR [95% CI] p-value
D3_OTHERAPLASTICANAEMIA 4.14 [3.24, 5.29] < 0.001
Birth year 0.995 [0.99, 1.0] 0.266

During the follow-up period (1.1.1998 — 31.12.2019), 646 out of 1166 females with D3_OTHERAPLASTICANAEMIA died.

Males

Parameter HR [95% CI] p-value
D3_OTHERAPLASTICANAEMIA 3.95 [3.02, 5.16] < 0.001
Birth year 0.991 [0.98, 1.0] 0.051

During the follow-up period (1.1.1998 — 31.12.2019), 660 out of 1238 males with D3_OTHERAPLASTICANAEMIA died.

Mortality risk

Mortality risk for people of age

years, who have D3_OTHERAPLASTICANAEMIA.

N-year risk Females Males
1 0.339% 0.703%
5 2.533% 4.934%
10 5.664% 12.691%
15 10.663% 22.855%
20 18.979% 36.188%

Relationships between endpoints

↥

Index endpoint: D3_OTHERAPLASTICANAEMIA – Other and unspecified aplastic anaemias

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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