Drug-induced aplastic anaemia

DRUGADVERS_APLAST_ANAEM

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D61.1# 1 out of 7 registries used, show all original rules.	75
4. Check minimum number of events None	75
5. Include endpoints None	75
6. Filter based on genotype QC (FinnGen only)	55

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	DRUGADVERS_APLAST_ANAEM
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D611
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Drug-induced aplastic anaemia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	549	296	245
Only index persons	425	235	190
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	69.55	71.11	67.73
Only index persons	68.94	70.57	66.92

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	55	28	27
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	64.36	60.56	68.30

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
60: Matched controls
600

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D61.1

ICD-10 Finland

Drug-induced aplastic anaemia

+∞

86.1

A04AA01

ATC

ondansetron; systemic, rectal

17.0

15.2

D70.82

ICD-10 Finland

Drug-induced neutropenia

65.3

13.6

A03FA01

ATC

metoclopramide; systemic, rectal

6.8

12.4

D64.9

ICD-10 Finland

Anaemia, unspecified

7.1

11.3

H02AB02

ATC

dexamethasone; systemic

6.5

10.3

WW500

NOMESCO Finland

Blood transfusion

14.3

10.1

N02AA05

ATC

oxycodone; systemic

5.1

8.4

Z51.5

ICD-10 Finland

Palliative care

8.1

7.9

WD125

NOMESCO Finland

Demanding cystostatic therapy of methastized malignancy

10.4

7.3

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

5.3

7.2

L04AX01

ATC

azathioprine; systemic

16.4

7.2

GD1AA

NOMESCO Finland

Thorax X-ray examination

4.4

6.9

198

WD105

NOMESCO Finland

Cystostatic therapy of methastized malignancy

11.2

6.7

Z51.1

ICD-10 Finland

Chemotherapy session for neoplasm

77.8

6.6

D70.89

ICD-10 Finland

Neutropenic splenomegaly

30.2

6.4

L03AA02

ATC

filgrastim; parenteral

14.7

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3021879) Hepatitis B virus core Ab [Presence] in Serum

6.16

8.54

2.1

1.7

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

4.39

6.99

10.5

2.8

0.75

0.81

mmol/l

1.30

(3018418) pH of Serum or Plasma

154

4.05

6.67

8.1

5.6

7.40

0.06

110

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

14.66

6.34

1.3

1.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

11.92

6.34

1.5

1.2

—

(3023368) Bacteria identified in Blood by Culture

130

3.86

6.25

8.2

4.6

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

9.33

5.63

1.3

2.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

5.89

5.46

1.8

1.5

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

9.73

5.30

1.5

1.3

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

11.49

5.22

2.6

2.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

3.93

5.02

2.4

1.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.67

4.87

2.4

1.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

106

3.33

4.72

10.4

2.2

—

(4035726) Immunohistochemistry procedure

4.11

4.69

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.63

4.65

2.4

1.9

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

10.03

4.43

2.9

1.4

—

u/ml

—

(3044640) Blood type and Crossmatch panel - Blood

157

3.02

4.24

8.3

2.3

—

(42870588) Differential panel, method unspecified - Blood

165

3.01

4.24

22.1

5.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

6.43

4.18

1.5

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

227

3.05

4.11

10.5

2.6

—

estimate

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

6.08

4.03

1.7

1.5

—

(40758558) Short blood count panel - Blood

148

2.86

3.83

26.0

6.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

3.01

3.70

2.5

2.3

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

6.02

3.67

1.8

1.6

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

6.40

3.47

1.9

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.86

3.40

2.8

1.9

—

(3006504) Eosinophils/Leukocytes in Blood

234

2.70

3.35

22.6

6.2

2.58

2.81

0.24

218

(3022096) Basophils/Leukocytes in Blood

234

2.70

3.35

22.6

6.2

0.58

0.63

0.20

218

(3019069) Monocytes/Leukocytes in Blood

236

2.66

3.27

23.0

6.3

11.19

8.92

1.57

220

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

8.17

3.13

2.0

1.6

—

(3018010) Neutrophils/Leukocytes in Blood

240

2.59

3.10

21.3

6.1

56.02

59.26

0.76

228

(3016502) Oxygen saturation in Arterial blood

3.25

3.04

5.2

3.6

96.78

95.10

0.76

(21494434) Karyotype in Bone marrow

10.73

3.03

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

10.73

3.03

1.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

10.73

3.03

1.0

1.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

109

2.61

2.95

1.9

1.8

2.33

1.60

mg/l

0.34

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.70

2.90

4.2

2.6

0.73

0.99

e6/l

0.26

(3002030) Lymphocytes/Leukocytes in Blood

245

2.50

2.89

23.1

6.2

25.36

26.07

0.17

230

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

8.94

2.80

1.0

2.2

4.30

3.87

mg/l

—

(3022145) Colonoscopy Study observation

2.98

2.65

1.6

1.3

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.79

2.64

12.1

4.3

104.47

104.06

mmol/l

0.11

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.60

2.62

2.1

1.8

—

(3035715) Granulocytes [#/volume] in Blood

5.92

2.61

8.8

2.5

3.95

5.61

e9/l

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

7.65

2.60

1.0

—

(3000991) Gas panel - Venous blood

3.01

2.54

8.5

4.0

—

(40768804) Tissue Pathology biopsy report

174

2.29

2.49

1.7

2.1

—

(44790049) Parainfluenza type 3 nucleic acid detection

6.69

2.42

1.4

1.6

—

(44790047) Parainfluenza type 1 nucleic acid detection

6.69

2.42

1.4

1.6

—

(44806118) Parainfluenza type 4 nucleic acid detection

6.69

2.42

1.4

1.6

—

(44790048) Parainfluenza type 2 nucleic acid detection

6.69

2.42

1.4

1.6

—

(3018095) Leukocytes [#/volume] in Urine

194

2.24

2.39

5.4

4.1

46.32

35.45

e6/l

0.17

142

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

3.22

2.34

7.3

3.3

24.28

24.19

mmol/l

—

(36304419) Bacteria [Presence] in Urine

144

2.26

2.34

4.1

2.9

—

estimate

—

(3030467) Casts [#/volume] in Urine by Automated count

144

2.26

2.34

4.4

3.0

1.40

0.58

e6/l

0.30

103

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.46

2.34

2.3

2.0

—

(3035933) Granulocytes/Leukocytes in Blood

5.00

2.33

10.8

2.2

55.67

62.07

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

5.00

2.33

1.5

1.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.90

2.22

1.8

2.7

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

2.90

2.22

5.8

3.5

107.64

124.98

g/l

1.39

(3022948) Iron [Moles/volume] in Serum or Plasma

2.40

2.17

3.6

3.0

20.49

12.88

umol/l

1.11

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.43

2.15

4.6

2.7

1.76

2.72

e6/l

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

5.34

2.11

3.8

1.6

4.02

2.63

u/ml

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

5.34

2.11

2.0

1.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

193

2.11

2.08

6.0

3.1

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

2.41

2.02

3.1

3.3

48.67

24.79

1.39

(3004789) Transferrin [Mass/volume] in Serum or Plasma

2.33

1.97

3.3

3.1

1.68

2.29

g/l

3.88

(3000494) Fungus identified in Specimen by Culture

2.58

1.96

1.2

1.3

—

(3002582) Erythrocytes [#/volume] in Urine

179

2.06

1.95

4.8

3.2

19.05

393.51

e6/l

0.52

136

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

2.84

1.89

6.8

6.7

1.22

1.21

mmol/l

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

3.80

1.89

2.0

1.5

—

(3027801) Oxygen [Partial pressure] in Arterial blood

2.53

1.88

5.6

3.3

12.07

12.69

kpa

0.18

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

2.53

1.88

5.6

3.3

4.80

4.96

kpa

0.47

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

3.02

1.87

6.3

3.4

1.39

1.67

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

2.58

1.83

3.2

2.2

34.73

37.11

u/l

0.12

(40760892) CBC W Ordered Manual Differential panel - Blood

115

2.11

1.82

14.8

6.9

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

0.00

1.78

0.0

1.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.16

1.78

2.7

2.0

—

(3052851) Hemolysis interference index of Serum or Plasma

4.09

1.75

4.4

2.80

3.17

index

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.72

1.74

7.6

3.4

1.05

1.21

mmol/l

—

(3015736) pH of Urine

212

1.96

1.74

6.0

3.4

6.16

6.25

0.18

118

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.39

1.71

2.0

1.5

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

3.79

1.65

2.0

1.4

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

3.79

1.65

2.2

2.5

9.38

11.14

mg/l

—

(40768797) Stomach Pathology biopsy report

2.16

1.55

1.2

—

(3020891) Body temperature

2.69

1.50

7.1

3.8

36.97

36.90

°c

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.69

1.50

6.7

3.3

0.76

0.74

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.69

1.50

14.0

5.6

23.50

24.30

mmol/l

—

(3019977) pH of Arterial blood

2.32

1.49

6.1

3.5

7.42

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

211

1.84

1.48

2.6

2.3

87.24

94.12

pmol/l

0.34

106

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.78

1.40

2.3

2.2

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

3.11

1.38

2.6

3.6

1.48

1.49

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.11

1.38

6.2

5.5

14.34

16.03

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.11

1.38

2.2

1.6

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.30

1.36

6.4

4.4

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

2.56

1.35

6.4

4.4

24.34

24.78

mmol/l

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.56

1.35

5.0

2.9

53.17

50.72

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

216

1.78

1.34

4.6

4.2

28.75

33.13

ng/l

0.17

156

(3025941) Bacteria identified in Stool by Culture

2.55

1.28

1.0

1.2

—

(3009261) Glucose [Presence] in Urine by Test strip

277

1.75

1.25

8.0

4.0

0.00

estimate

—

(3037467) Urinalysis macro (dipstick) panel - Urine

349

1.82

1.23

7.1

4.6

—

(3000963) Hemoglobin [Mass/volume] in Blood

518

0.52

1.18

79.5

25.7

117.98

135.20

g/l

5.86

509

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

2.50

1.17

5.1

2.8

22.06

24.64

mmol/l

—

(3010813) Leukocytes [#/volume] in Blood

517

0.53

1.13

78.5

25.5

5.97

6.63

e9/l

1.02

502

(3035941) MCH [Entitic mass]

517

0.53

1.13

78.7

25.4

31.40

30.46

2.97

508

(3024731) MCV [Entitic mean volume] in Red Blood Cells

517

0.53

1.13

78.7

25.5

94.26

91.41

3.06

508

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

517

0.53

1.13

79.7

25.7

35.61

40.45

5.91

508

(3026361) Erythrocytes [#/volume] in Blood

517

0.53

1.13

78.6

25.5

3.83

4.46

e12/l

6.27

502

(3021601) Nitrite [Presence] in Urine by Test strip

272

1.69

1.13

8.2

4.0

0.00

estimate

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.50

1.11

1.0

1.1

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.27

1.10

7.0

2.9

0.67

0.69

—

(3007461) Platelets [#/volume] in Blood

516

0.53

1.09

78.7

25.6

200.46

243.06

e9/l

2.49

503

(3035350) Ketones [Presence] in Urine by Test strip

274

1.67

1.09

8.2

4.0

134.44

0.00

estimate

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.20

1.07

7.0

2.9

1.19

1.45

—

(3007164) IgA [Mass/volume] in Serum or Plasma

110

1.76

1.05

2.1

1.5

2.58

2.21

g/l

0.30

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.07

1.01

5.4

2.7

117.86

126.47

g/l

—

(3042936) Bacteria identified in Isolate by Culture

1.86

0.97

1.8

2.1

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

1.77

0.95

4.5

11353.57

81.93

ng/l

0.51

(40761535) Cells panel - Urine sediment

1.99

0.92

6.7

2.6

—

(40761511) CBC panel - Blood by Automated count

485

0.60

0.89

32.7

15.0

—

(3048689) Calprotectin [Mass/mass] in Stool

1.85

0.89

8.5

1.4

592.09

168.90

ug/g

0.59

(42868678) Cholesterol non HDL [Moles/volume] in Serum or Plasma

0.00

0.81

0.0

1.9

—

3.55

—

(1002224) Polysomnography panel

0.00

0.81

0.0

1.0

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

221

1.50

0.76

3.4

2.6

70.29

76.24

nmol/l

0.65

195

(3003694) ABO and Rh group [Type] in Blood

139

1.54

0.72

2.1

1.4

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.00

0.72

1.2

1.0

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.79

0.65

3.4

2.5

24.00

24.34

mmol/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.65

0.64

1.3

1.7

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.65

0.64

2.1

1.7

—

(3019060) Gas panel - Arterial blood

1.79

0.60

5.0

2.5

—

(3029937) Albumin [Presence] in Urine by Test strip

165

1.42

0.55

10.7

4.0

0.00

estimate

—

(36660697) Celiac disease serology panel - Serum

1.60

0.55

1.3

1.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.48

0.54

22.2

9.0

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

498

0.67

0.53

64.1

22.1

89.76

82.16

umol/l

0.57

493

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

497

0.68

0.51

39.7

12.1

26.17

25.00

u/l

0.25

482

(1761868) Lipid panel - Serum or Plasma

161

0.68

0.49

4.6

3.6

—

(3026008) Bacteria identified in Urine by Culture

159

1.39

0.49

6.2

3.1

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

485

0.71

0.44

53.6

19.6

4.00

3.99

mmol/l

0.16

474

(3019550) Sodium [Moles/volume] in Serum or Plasma

485

0.71

0.44

50.8

19.4

138.49

139.60

mmol/l

2.04

476

(3007853) Bacteria identified in Skin by Aerobe culture

1.38

0.42

1.9

1.4

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.44

0.42

1.5

1.4

11.84

9.56

u/ml

—

(3009343) pH of Capillary blood

1.51

0.41

6.2

2.9

7.42

7.43

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.51

0.41

2.6

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

280

1.31

0.40

4.3

3.3

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

392

1.34

0.40

61.5

21.2

15.06

13.75

4.31

387

(40761536) Microorganisms panel - Urine sediment

1.34

0.34

12.8

4.0

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

193

0.77

0.33

1.6

2.0

1.28

1.36

mmol/l

0.19

155

(3041096) Erythrocytes [Presence] in Urine by Automated

156

0.79

0.25

11.1

3.2

0.00

estimate

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.21

0.0

1.1

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.7

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.1

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.21

0.0

1.1

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.7

—

12.45

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.1

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

1.8

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.2

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

0.06

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

1.55

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

0.75

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.8

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.20

0.0

1.3

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.20

0.0

1.1

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.24

0.17

1.5

1.4

101.12

31.44

iu/ml

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

210

1.15

0.15

10.1

3.8

0.00

estimate

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

155

1.14

0.10

3.1

4.4

17.40

24.28

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.10

0.09

2.5

2.3

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.08

0.09

1.0

1.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

171

0.91

0.06

3.9

4.1

5.46

8.50

mg/mmol

0.31

116

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.95

0.00

1.6

1.8

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

12.33

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.8

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

2.0

—

27.43

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.8

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.0

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

-0.00

0.0

1.6

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.3

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

3.6

—

157.10

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

1.6

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

-0.00

0.0

1.0

—

7.63

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

-0.00

0.0

1.6

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.3

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

1.1

—

28.44

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

5.95

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.1

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

54.14

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3002256) Pathology report gross observation

0.83

-0.00

1.2

—

(40759040) C peptide [Moles/volume] in Serum or Plasma --post meal

0.00

-0.00

0.0

1.2

—

1.01

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.00

-0.00

2.8

2.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.3

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

14.00

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.2

—

173.50

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

-0.00

0.0

1.7

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.2

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3025130) Human papilloma virus identified in Specimen

0.00

-0.00

0.0

1.9

—

Mortality – FinRegistry

↥

Association

Association between endpoint DRUGADVERS_APLAST_ANAEM and mortality.

Females

Parameter	HR [95% CI]	p-value
DRUGADVERS_APLAST_ANAEM	4.979 [2.92, 8.49]	< 0.001
Birth year	0.995 [0.99, 1.0]	0.247

During the follow-up period (1.1.1998 — 31.12.2019), 149 out of 248 females with DRUGADVERS_APLAST_ANAEM died.

Males

Parameter	HR [95% CI]	p-value
DRUGADVERS_APLAST_ANAEM	6.784 [3.45, 13.35]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.001

During the follow-up period (1.1.1998 — 31.12.2019), 138 out of 209 males with DRUGADVERS_APLAST_ANAEM died.

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_APLAST_ANAEM.

N-year risk	Females	Males
1	0.537%	0.922%
5	3.103%	7.005%
10	7.649%	16.357%
15	14.183%	29.634%
20	22.687%	44.419%

Relationships between endpoints

↥

Index endpoint: DRUGADVERS_APLAST_ANAEM – Drug-induced aplastic anaemia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced aplastic anaemia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints