Nonhereditary hypogammaglobulinemia

D3_NONHEREDHYPOGAMMA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D80.1
  • Cause of death: ICD-10 D80.1

2 out of 7 registries used, show all original rules.

456

4. Check minimum number of events

None

456

5. Include endpoints

None

456

6. Filter based on genotype QC (FinnGen only)

400

Control definitions (FinnGen only)

Control exclude
D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D80
Name in latin
Hypogammaglobulinaemia non familialis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1373 825 543
Only index persons 1282 786 496
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 50.05 52.53 46.32
Only index persons 49.45 52.05 45.35

-FinnGen-

Key figures

All Female Male
Number of individuals 400 263 137
Unadjusted period prevalence (%) 0.08 0.09 0.06
Median age at first event (years) 52.53 51.55 54.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
412
Matched controls
4120
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
307.7
406
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
231.9
200
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
229.3
198
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
25.7
189.1
149
89
ZX120
NOMESCO Finland
Intravenous
16.7
177.2
193
207
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
22.4
161.3
133
86
WW200
NOMESCO Finland
Immunization
40.6
153.7
97
31
J47
ICD-10 Finland
Bronchiectasis
44.4
138.9
85
24
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
23.5
131.2
102
57
J01MA12
ATC
levofloxacin; systemic
10.3
128.7
221
415
J01MA14
ATC
moxifloxacin; systemic
12.5
126.5
155
190
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
114.0
104
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
25.7
113.1
83
40
J18.9
ICD-10 Finland
Pneumonia, unspecified
8.4
106.4
239
582
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
10.7
105.4
141
191
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
103.6
95
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
15.3
99.6
96
80
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
97.9
90
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
11.3
97.3
120
145
TDM10
NOMESCO Finland
Puncture of maxillary antrum
14.6
96.6
96
84
H02AB09
ATC
hydrocortisone; systemic
23.3
88.8
67
34
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
8.0
86.8
156
293
TPH04
NOMESCO Finland
Cathetrisation of vein
6.8
84.5
214
564
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
11.1
82.4
99
114
A49.9
ICD-10 Finland
Bacterial infection, unspecified
8.7
80.9
124
194
6BA02, ,
NOMESCO Finland
319.6
79.5
78
*
R50.9
ICD-10 Finland
Fever, unspecified
7.0
79.2
167
366
TGC00
NOMESCO Finland
Bronchial lavation
19.9
78.0
63
37
GD1AA
NOMESCO Finland
Thorax X-ray examination
7.9
76.8
326
1341
UGC12
NOMESCO Finland
Flexible bronchoscopy
10.8
76.7
93
108
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
75.4
70
*
H02AB06
ATC
prednisolone; systemic
8.0
75.4
331
1396
J45.1
ICD-10 Finland
Nonallergic asthma
8.7
71.5
105
155
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.8
70.9
235
765
H02AB07
ATC
prednisone; oral
6.7
69.2
141
295
XW000
NOMESCO Finland
Bone marrow biopsy
13.6
68.0
68
59
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.1
66.2
104
165
L03AA02
ATC
filgrastim; parenteral
12.9
64.0
66
60
C01CA24
ATC
epinephrine; parenteral
7.9
63.2
101
163
GD1AD
NOMESCO Finland
Thorax CT examination
8.9
62.3
87
120
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
9.2
58.1
78
102
J32.4
ICD-10 Finland
Chronic pansinusitis
21.3
57.0
44
23
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
9.6
56.9
73
90
R03BB04
ATC
tiotropium bromide; inhalant
7.3
55.6
94
160
J01.0
ICD-10 Finland
Acute maxillary sinusitis
4.8
55.5
220
793
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
52.2
49
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
4.8
51.0
168
519
J45.9
ICD-10 Finland
Asthma, unspecified
4.7
49.2
161
493
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
+∞
48.9
46
*
J45.0
ICD-10 Finland
Predominantly allergic asthma
6.0
47.8
99
205
J45.8
ICD-10 Finland
Mixed asthma
12.0
47.1
50
47
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.3
47.1
229
934
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
4.6
46.3
155
480
UDH02
NOMESCO Finland
Rhinopharyngoscopy
6.4
45.9
87
165
Z01.8
ICD-10 Finland
Other specified special examinations
4.3
44.9
176
611
J01FA06
ATC
roxithromycin; oral
4.2
44.9
262
1203
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
8.0
43.3
64
93
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.1
42.8
86
172
A07AA02
ATC
nystatin; oral
7.5
42.7
67
104
WW500
NOMESCO Finland
Blood transfusion
9.5
42.2
53
63
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.6
42.1
94
207
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
12.9
41.8
42
36
J46
ICD-10 Finland
Status asthmaticus
11.6
41.8
45
43
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
8.8
41.0
55
71
XG410
NOMESCO Finland
Flow-volume spirometry
10.0
40.7
49
55
JN4BD
NOMESCO Finland
Extensive body CT
5.4
39.5
92
210
J01MA02
ATC
ciprofloxacin; systemic
3.7
38.1
227
1024
J05AB11
ATC
valaciclovir; oral
4.2
37.9
136
436
R03BA02
ATC
budesonide; inhalant
4.1
37.9
144
481
L04AX01
ATC
azathioprine; systemic
8.5
37.8
52
69
UJF32
NOMESCO Finland
Coloscopy
3.8
37.6
169
633
J01FF01
ATC
clindamycin; systemic
3.7
37.1
187
754
M05BA04
ATC
alendronic acid; oral
5.9
37.1
75
150
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.4
36.7
83
184
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
4.2
36.7
313
1769
R03DA04
ATC
theophylline; systemic, rectal
8.3
36.5
51
69
R03BB01
ATC
ipratropium bromide; inhalant
9.4
35.9
45
53
R03DC03
ATC
montelukast; oral
4.0
35.7
134
441
A41.9
ICD-10 Finland
Sepsis, unspecified
9.7
35.2
43
49
R03AK06
ATC
salmeterol and fluticasone; inhalant
4.3
34.9
115
344
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
33.8
32
*
WZC30
NOMESCO Finland
Teaching
4.0
33.6
126
413
M04AA01
ATC
allopurinol; systemic
4.8
33.3
87
217
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.5
33.0
183
773
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
10.4
32.9
38
40
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
9.4
32.8
41
48
JN6AD
NOMESCO Finland
CT of torso and neck
13.3
32.7
32
26
ZXA10
NOMESCO Finland
Bilateral
3.9
32.7
126
420
J01FA15
ATC
telithromycin; oral
4.5
32.4
92
245
C03CA01
ATC
furosemide; systemic
3.6
32.2
153
585
R03AK08
ATC
formoterol and beclometasone; inhalant
6.7
32.1
55
93
UJF30
NOMESCO Finland
Ileoscopy through colon
4.5
31.8
90
239
WE300
NOMESCO Finland
Profylactive therapy of malignancy with biomoidiers
325.0
30.2
30
*
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
10.2
30.1
35
37
JN4AD
NOMESCO Finland
Body CT examination
4.4
30.0
89
244
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.8
28.8
107
345
R03AC12
ATC
salmeterol; inhalant
6.7
28.7
48
79
R81
ICPC
Pneumonia
7.0
28.4
46
73
TPX10
NOMESCO Finland
Implantation of vascular injection port
8.3
27.6
38
50
WVC10
NOMESCO Finland
Subcutaneous infusion of drugs
39.7
26.6
33
9
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
8.6
26.4
35
44
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
64.5
26.3
30
5
R03AC02
ATC
salbutamol; inhalant
3.3
26.2
298
1832
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
4.9
26.1
63
146
R01AD08
ATC
fluticasone; nasal
3.0
25.8
181
852
JN3AD
NOMESCO Finland
Abdominal CT examination
3.8
25.7
95
303
J01FA10
ATC
azithromycin; systemic
3.4
25.6
318
2045
L04AA06
ATC
mycophenolic acid; systemic
11.1
25.6
28
27
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
8.0
25.4
36
49
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
32.5
25.4
33
11
Z3231
NOMESCO Finland
Registered nurse
3.0
25.1
166
755
N17.9
ICD-10 Finland
Acute renal failure, unspecified
8.0
25.0
35
47
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
3.1
24.5
289
1785
N02AA05
ATC
oxycodone; systemic
3.4
24.3
107
382
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.3
24.2
70
187
R03BA08
ATC
ciclesonide; inhalant
4.1
24.2
76
216
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
7.5
24.1
36
52
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
8.0
24.1
34
46
H02AB04
ATC
methylprednisolone; systemic
3.5
24.0
98
333
A04AA01
ATC
ondansetron; systemic, rectal
4.3
23.6
68
181
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
26.6
23.4
32
13
SPAT1262
SPAT
Handing over of treatment supplies
3.4
23.3
104
374
A03FA01
ATC
metoclopramide; systemic, rectal
3.0
23.1
147
649
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.9
23.0
55
126
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.3
22.9
35
52
R03AC13
ATC
formoterol; inhalant
5.6
22.7
46
91
J02AC01
ATC
fluconazole; systemic
2.7
22.5
225
1254
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.4
22.1
60
152
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
7.0
22.1
35
54
ZX108
NOMESCO Finland
Inhalation
41.1
22.0
27
7
WX892
NOMESCO Finland
Monitored bed care
4.5
21.9
58
144
J01FA09
ATC
clarithromycin; systemic
2.7
21.9
187
959
R01AD09
ATC
mometasone; nasal
2.7
21.6
253
1516
R01AD05
ATC
budesonide; nasal
4.3
21.5
61
160
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.6
21.4
82
266
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
36.0
21.4
27
8
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.0
21.4
121
498
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
20.8
21.2
31
16
D83.8
ICD-10 Finland
Other common variable immunodeficiencies
+∞
21.0
20
*
ZYC01
NOMESCO Finland
Remote contact by phone
4.4
21.0
58
149
WX882
NOMESCO Finland
High dependency care
9.2
20.9
26
30
A46
ICD-10 Finland
Erysipelas
3.3
20.6
92
329
A01AB09
ATC
miconazole; local oral
4.1
20.4
62
171
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
8.9
20.3
26
31
R03BA05
ATC
fluticasone; inhalant
3.0
20.3
119
498
A07AA09
ATC
vancomycin; oral
22.2
20.2
29
14
R06AE07
ATC
cetirizine; oral
2.6
20.1
239
1423
OAB50, ,
SPAT
4.1
20.1
60
163
J01AA02
ATC
doxycycline; systemic
4.0
20.1
365
2715
J01DA08
ATC
[U] cefaclor
3.5
20.1
78
255
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
20.0
19
*
R03AC03
ATC
terbutaline; inhalant
3.3
19.7
89
320
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
6.2
19.6
35
61
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
16.7
19.6
31
20
ZXD05
NOMESCO Finland
Urgent procedure
2.6
19.5
163
817
WZC00
NOMESCO Finland
Treatment plan or consultation
2.6
19.4
201
1116
J31.0
ICD-10 Finland
Chronic rhinitis
3.6
19.4
71
223
D70.89
ICD-10 Finland
Neutropenic splenomegaly
24.0
19.3
27
12
TAB00
NOMESCO Finland
Lumbar puncture
4.7
19.3
47
109
N02AX02
ATC
tramadol; systemic, rectal
2.5
19.0
219
1274
D84.18
ICD-10 Finland
Other specified defect in the complement system
+∞
18.9
18
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
22.1
18.9
27
13
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
40.5
18.7
23
6
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
5.5
18.5
37
72
UDM02
NOMESCO Finland
Sinoscopy
7.5
18.4
27
38
R03AK11
ATC
formoterol and fluticasone; inhalant
7.5
18.4
27
38
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
26.5
18.4
25
10
SPAT1255
SPAT
Intravenous administration of medicine
4.8
18.3
44
101
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.1
18.2
88
328
A02BC02
ATC
pantoprazole; systemic
2.9
18.1
319
2249
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
21.3
18.0
26
13
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
21.3
18.0
26
13
A01AB04
ATC
amphotericin B; local oral
5.3
17.9
38
78
D83.1
ICD-10 Finland
Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
+∞
17.8
17
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
6.2
17.7
31
53
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
99.4
17.7
19
*
J01DA06
ATC
[U] cefuroxime
3.0
17.7
96
382
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
5.7
17.6
34
64
R06.0
ICD-10 Finland
Dyspnoea
2.6
17.5
144
710
D64.9
ICD-10 Finland
Anaemia, unspecified
3.7
17.3
61
186
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
4.7
17.3
42
97
XF400
NOMESCO Finland
ECG with 12 standard connections
3.0
17.0
86
328
L04AX03
ATC
methotrexate; systemic
3.4
17.0
69
231
Z3226
NOMESCO Finland
Physiotherapist
2.8
16.9
108
468
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
66.2
16.9
19
*
ZX121
NOMESCO Finland
Central venous catheter
36.8
16.8
21
6
D80.6
ICD-10 Finland
Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
+∞
16.8
16
*
ZX112
NOMESCO Finland
Subcutaneous
6.3
16.7
29
49
UJF92
NOMESCO Finland
Capsular endoscopy
7.3
16.7
25
36
Z2221
NOMESCO Finland
Medical doctor
2.5
16.7
149
761
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.6
16.6
42
100
GD1DG
NOMESCO Finland
Extremely extensive MRI examination of pleura with high field magnet
176.9
16.6
17
*
H04.10
ICD-10 Finland
Dry eye syndrome
3.0
16.5
83
316
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
31.5
16.3
21
7
R4110
NOMESCO Finland
Physiotherapy
2.4
16.1
152
794
R03AK07
ATC
formoterol and budesonide; inhalant
2.6
16.0
121
569
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
18.1
15.8
24
14
D84.9
ICD-10 Finland
Immunodeficiency, unspecified
+∞
15.7
15
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
15.7
85
336
GD1CG
NOMESCO Finland
Extensive examination of lungs and pleura with high intensity magnet
88.5
15.7
17
*
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.8
15.7
91
374
1XC02, ,
NOMESCO Finland
29.9
15.3
20
7
B29
ICPC
Lymph/immune mech sympt/complt other
29.9
15.3
20
7
D70.82
ICD-10 Finland
Drug-induced neutropenia
7.1
15.0
23
34
A41.8
ICD-10 Finland
Other specified sepsis
12.0
15.0
27
24
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.8
14.9
91
383
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
4.4
14.8
39
96
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.2
14.8
67
239
L01BA01
ATC
methotrexate; systemic
5.7
14.7
28
52
A02BC05
ATC
esomeprazole; systemic
2.3
14.6
203
1239
J45
ICD-10 Finland
Asthma
3.2
14.6
66
235
L03AA13
ATC
pegfilgrastim; parenteral
4.0
14.5
43
116
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
17.8
14.5
22
13
R03DC01
ATC
zafirlukast; oral
11.0
14.4
27
26
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.2
14.0
39
100
XQ800
NOMESCO Finland
Prick test
3.4
14.0
54
174
P01BA02
ATC
hydroxychloroquine; oral
3.3
14.0
59
201
J96.0
ICD-10 Finland
Acute respiratory failure
31.3
14.0
18
6
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.9
13.9
72
277
J01.1
ICD-10 Finland
Acute frontal sinusitis
6.5
13.9
23
37
C10AC01
ATC
colestyramine; oral
5.4
13.8
28
55
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
5.4
13.8
28
55
R05
ICD-10 Finland
Cough
2.4
13.8
119
591
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.5
13.6
49
151
J06BA02
ATC
immunoglobulins, normal human, for intravascular adm.; systemic
+∞
13.6
13
*
D86.0
ICD-10 Finland
Sarcoidosis of lung
+∞
13.6
13
*
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
+∞
13.6
13
*
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
13.5
13.6
23
18
WVA20
NOMESCO Finland
Medicine administration
5.3
13.6
28
56
XG474
NOMESCO Finland
Exhalation nntrogen oxide
5.1
13.5
29
60
H65.3
ICD-10 Finland
Chronic mucoid otitis media
5.8
13.5
25
45
ZXE20
NOMESCO Finland
More than three and less than five hours
2.8
13.3
78
320
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.7
13.3
32
73
TQW99
NOMESCO Finland
Other minor procedure on skin
4.2
13.3
37
95
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.4
13.3
118
592
B99
ICPC
Blood/lymph/spleen disease other
41.5
13.2
16
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
5.7
13.2
25
46
ZXA00
NOMESCO Finland
Right side
2.3
13.2
132
698
J01DA01
ATC
[U] cefalexin
2.3
13.1
282
2020
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
5.9
13.0
24
43
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
19.8
13.0
19
10
ZXA05
NOMESCO Finland
Left side
2.4
13.0
120
612
R01AD12
ATC
fluticasone furoate; nasal
2.2
12.9
167
979
P01AB01
ATC
metronidazole; oral, rectal
2.1
12.9
202
1276
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
5.2
12.8
27
55
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
16.1
12.7
20
13
XG466
NOMESCO Finland
Sleep oxymetry
5.7
12.7
24
44
A07EA06
ATC
budesonide; oral, local oral
4.2
12.7
35
89
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.5
12.7
32
76
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.9
12.7
66
254
L01BB05
ATC
fludarabine; systemic
72.1
12.7
14
*
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
72.1
12.7
14
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
33.2
12.7
16
5
R06AE09
ATC
levocetirizine; oral
2.6
12.7
84
367
B01AB05
ATC
enoxaparin; parenteral
2.2
12.6
148
833
ZX100
NOMESCO Finland
Oral
13.8
12.6
21
16
H66.0
ICD-10 Finland
Acute suppurative otitis media
3.1
12.5
57
203
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.8
12.4
67
263
H65.2
ICD-10 Finland
Chronic serous otitis media
10.1
12.4
24
25
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
27.6
12.1
16
6
E0000UV, ,
ATC
2.1
12.1
202
1297
N03AX12
ATC
[U] gabapentin; oral
2.5
12.1
93
436
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
3.3
12.0
47
153
A02BC01
ATC
omeprazole; systemic
2.2
11.9
130
707
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.3
11.9
115
595
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.5
11.9
44
138
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
11.9
131
716
A28
ICPC
Limited function/disability NOS
2.6
11.9
77
332
J05AB01
ATC
aciclovir; systemic
2.3
11.8
119
626
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.1
11.8
196
1252
R03BA01
ATC
beclometasone; inhalant
2.6
11.8
77
333
A03
ICPC
Fever
2.4
11.8
100
489
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
31.0
11.7
15
5
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.9
11.7
58
217
390
Kela drug reimbursment
Ibrutinib
66.9
11.7
13
*
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
23.7
11.7
16
7
N03AX16
ATC
[U] pregabalin
2.3
11.6
117
616
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.4
11.5
90
424
UDC00
NOMESCO Finland
Ear microscopy
3.3
11.5
47
157
R03AK03
ATC
[U] fenoterol and ipratropium bromide
4.5
11.4
28
65
A06AD11
ATC
lactulose; oral
2.7
11.4
68
281
B34.9
ICD-10 Finland
Viral infection, unspecified
4.8
11.3
26
57
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.9
11.3
35
97
C82.1
ICD-10 Finland
Follicular lymphoma grade II
17.7
11.3
17
10
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
11.2
202
1322
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
20.7
11.2
16
8
PJA10
NOMESCO Finland
Exploration of lymph nodes
11.6
11.2
20
18
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.9
11.1
56
211
Z2446
NOMESCO Finland
Social worker
3.3
11.1
44
144
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
6.0
11.1
20
35
L04AA01
ATC
[U] ciclosporin
14.4
11.1
18
13
I50.9
ICD-10 Finland
Heart failure, unspecified
3.0
11.0
53
195
B99
ICD-10 Finland
Other and unspecified infectious diseases
8.6
11.0
23
28
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.2
11.0
30
76
N05CD07
ATC
temazepam; oral
2.9
10.9
56
213
C03DA01
ATC
spironolactone; oral
2.8
10.9
60
237
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.7
10.9
65
268
ZXH09, ,
SPAT
5.3
10.9
22
43
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
10.9
79
359
ZY010
NOMESCO Finland
Hospital outpatient
3.4
10.9
40
125
ZXE00
NOMESCO Finland
One hour or less
2.0
10.8
180
1141
J20
ICD-10 Finland
Acute bronchitis
2.7
10.7
64
264
WX872
NOMESCO Finland
Intensive care
4.0
10.7
31
82
1512
Kela drug reimbursment
Ibrutinib
61.6
10.7
12
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.8
10.7
59
234
A02BA03
ATC
famotidine; systemic
5.0
10.6
23
48
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.7
10.6
65
272
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.0
10.6
154
930
J01DB01
ATC
cefalexin; oral
2.7
10.5
363
3008
L01XE27
ATC
[U] ibrutinib
112.8
10.5
11
*
D81.0
ICD-10 Finland
Severe combined immunodeficiency [SCID] with reticular dysgenesis
+∞
10.5
10
*
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
4.5
10.5
26
61
A10AB05
ATC
insulin aspart; parenteral
3.1
10.4
45
155
N05CF01
ATC
zopiclone; oral
2.0
10.4
150
901
C82.9
ICD-10 Finland
Follicular lymphoma, unspecified
33.5
10.4
13
*
5BA08, ,
NOMESCO Finland
24.1
10.3
14
6
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
24.1
10.3
14
6
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
13.6
10.2
17
13
A02BA02
ATC
ranitidine; systemic
2.3
10.2
88
431
L04AA13
ATC
[U] leflunomide
5.5
10.2
20
38
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
8.8
10.2
21
25
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
10.4
10.1
19
19
J01.9
ICD-10 Finland
Acute sinusitis, unspecified
3.7
10.1
33
95
WX002
NOMESCO Finland
Sedation and analgesia
2.3
10.0
89
441
R01AD58
ATC
fluticasone, combinations; nasal
2.1
10.0
132
765
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.8
10.0
53
205
C91.9
ICD-10 Finland
Lymphoid leukaemia, unspecified
41.1
10.0
12
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
3.1
10.0
45
159
A10AC01
ATC
insulin (human); parenteral
3.1
10.0
43
148
L28
ICPC
Limited function/disability (L)
2.3
10.0
85
414
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.6
10.0
33
96
R75
ICPC
Sinusitis acute/chronic
3.2
10.0
40
132
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
4.6
9.9
24
55
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
4.6
9.9
24
55
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.9
9.9
30
82
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
20.6
9.9
14
7
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
7.7
9.8
22
30
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.3
9.8
39
128
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.9
9.8
29
78
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
13.8
9.7
16
12
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
5.5
9.7
19
36
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.2
9.7
40
134
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
4.5
9.7
24
56
R13
ICD-10 Finland
Dysphagia
3.1
9.7
42
145
J01CA04
ATC
amoxicillin; systemic
2.6
9.7
361
3014
PJD45
NOMESCO Finland
Excision of inguinal lymph nodes
56.4
9.7
11
*
R96
ICPC
Asthma
2.7
9.7
56
227
N06AA09
ATC
amitriptyline; systemic
2.8
9.7
53
209
J01.4
ICD-10 Finland
Acute pansinusitis
11.8
9.6
17
15
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
2.1
9.6
108
589
R05
ICPC
Cough
2.0
9.6
132
776
Z3229
NOMESCO Finland
Other healthcare associate professional
2.9
9.6
46
169
J01FA01
ATC
erythromycin; systemic
2.5
9.5
69
312
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.4
9.5
72
332
S97
ICPC
Chronic ulcer skin
3.2
9.4
39
131
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.7
9.4
22
49
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.7
9.4
30
85
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
+∞
9.4
9
*
D81.1
ICD-10 Finland
Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
+∞
9.4
9
*
D73.1
ICD-10 Finland
Hypersplenism
+∞
9.4
9
*
D84.1
ICD-10 Finland
Defects in the complement system
+∞
9.4
9
*
M81.4
ICD-10 Finland
Drug-induced osteoporosis
22.3
9.4
13
6
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
9.9
9.4
18
19
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
7.6
9.3
21
29
A02BC03
ATC
lansoprazole; oral
2.0
9.3
129
759
N05BA01
ATC
diazepam; systemic, rectal
2.4
9.3
68
309
A04AA02
ATC
granisetron; systemic, transdermal
3.0
9.3
42
149
H10.0
ICD-10 Finland
Mucopurulent conjunctivitis
2.9
9.3
46
172
K90.0
ICD-10 Finland
Coeliac disease
4.5
9.2
23
54
S01AA01
ATC
chloramphenicol; ophthalmic
3.6
9.2
31
91
A06AC01
ATC
ispaghula (psylla seeds); oral
2.0
9.2
122
705
TK800
NOMESCO Finland
Hemodialysis
8.6
9.2
19
23
ZX114
NOMESCO Finland
Intramuscular
7.3
9.1
21
30
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.6
9.1
30
87
J32.8
ICD-10 Finland
Other chronic sinusitis
16.0
9.1
14
9
J01CF05
ATC
flucloxacillin; systemic
2.9
9.1
46
174
C82.01
ICD-10 Finland
Follicular nodular lymphoma, grade I
37.6
9.1
11
*
ZX110
NOMESCO Finland
Intracutaneous
37.6
9.1
11
*
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.9
9.0
27
73
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.6
9.0
56
235
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
9.0
161
1031
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
9.0
171
1117
M05BX04
ATC
denosumab; parenteral
3.3
9.0
35
113
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
9.0
66
300
J32.2
ICD-10 Finland
Chronic ethmoidal sinusitis
19.1
9.0
13
7
B28
ICPC
Limited function/disability (B)
24.6
9.0
12
5
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
24.6
9.0
12
5
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
7.1
9.0
21
31
Z71.8
ICD-10 Finland
Other specified counselling
1.9
8.9
168
1094
X57
ICD-10 Finland
Unspecified privation
5.1
8.9
19
39
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
8.9
90
469
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.0
8.9
41
147
WVA20, ,
SPAT
3.8
8.9
27
74
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
8.8
105
583
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
6.9
8.8
21
32
L04AD01
ATC
ciclosporin; systemic
7.9
8.7
19
25
Q79.6
ICD-10 Finland
Ehlers-Danlos syndrome
51.1
8.7
10
*
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
4.9
8.7
19
40
ZXH06, ,
SPAT
3.2
8.7
35
116
J15.8
ICD-10 Finland
Other bacterial pneumonia
16.7
8.6
13
8
ZYC01, ,
SPAT
2.5
8.6
59
260
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
20.5
8.5
12
6
L01AA01
ATC
cyclophosphamide; systemic
20.5
8.5
12
6
318
Kela drug reimbursment
Teriparatide
20.5
8.5
12
6
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
20.5
8.5
12
6
J05AH02
ATC
oseltamivir; oral
20.5
8.5
12
6
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.0
8.5
115
668
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.2
8.5
34
112
R04.2
ICD-10 Finland
Haemoptysis
4.6
8.5
20
45
J01DC02
ATC
cefuroxime; systemic
3.2
8.4
34
113
2790C
ICD-9 Finland
Disorders involving the immune mechanism, Deficiency of humoral immunity[DEFICIENTIA IMMUNOGLOBULINI ALIA]
+∞
8.4
8
*
A07EC01
ATC
sulfasalazine; oral, rectal
2.8
8.3
44
170
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
4.4
8.3
21
50
4730A
ICD-9 Finland
Chronic sinusitis, Maxillary
6.7
8.3
20
31
B03XA02
ATC
darbepoetin alfa; parenteral
7.8
8.2
18
24
R06.2
ICD-10 Finland
Wheezing
3.6
8.2
27
78
N03AE01
ATC
clonazepam; systemic
3.2
8.2
33
109
JAH00
NOMESCO Finland
Laparotomy
4.7
8.2
19
42
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
4.2
8.2
22
55
XCK00
NOMESCO Finland
Perimetry
3.3
8.2
32
104
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
17.6
8.1
12
7
M05BA07
ATC
risedronic acid; oral
6.5
8.1
20
32
K90.9
ICD-10 Finland
Intestinal malabsorption, unspecified
34.1
8.1
10
*
I50.0
ICD-10 Finland
Congestive heart failure
3.4
8.1
30
94
D07AB08
ATC
desonide; topical
2.4
8.1
59
267
J18.1
ICD-10 Finland
Lobar pneumonia, unspecified
10.3
8.1
15
15
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
7.5
8.0
18
25
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
4.4
8.0
20
47
XA800
NOMESCO Finland
Neuropsychological investigation
3.1
8.0
33
111
DMB00
NOMESCO Finland
Endonasal trephine of maxillary antrum
13.4
7.9
13
10
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.9
7.9
23
61
R01AD01
ATC
beclometasone; nasal
2.2
7.9
78
402
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.9
7.9
37
134
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
7.2
7.9
18
26
TPH40
NOMESCO Finland
Insertion of a long peripheral venous catheter
11.1
7.8
14
13
EBA10
NOMESCO Finland
Operative extraction of tooth
2.2
7.8
70
347
3AC01, ,
NOMESCO Finland
15.4
7.8
12
8
E000006, ,
ATC
2.9
7.7
38
141
UGC02
NOMESCO Finland
Rigid bronchoscopy
45.9
7.7
9
*
J20.6
ICD-10 Finland
Acute bronchitis due to rhinovirus
45.9
7.7
9
*
E23.03
ICD-10 Finland
Lack of ACTH
45.9
7.7
9
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.9
7.7
23
62
E87.6
ICD-10 Finland
Hypokalaemia
3.7
7.7
24
67
J12.1
ICD-10 Finland
Respiratory syncytial virus pneumonia
18.8
7.6
11
6
H05AA02
ATC
teriparatide; parenteral
18.8
7.6
11
6
K59.1
ICD-10 Finland
Functional diarrhoea
3.0
7.6
35
125
B25.9
ICD-10 Finland
Cytomegaloviral disease, unspecified
25.5
7.6
10
*
J01
ICD-10 Finland
Acute sinusitis
2.9
7.6
37
137
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
7.5
74
380
R01BA52
ATC
pseudoephedrine, combinations; oral
1.8
7.5
143
925
B01.9
ICD-10 Finland
Varicella without complication
81.5
7.4
8
*
C83.00
ICD-10 Finland
Lymphocytic lymphoma
81.5
7.4
8
*
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.4
7.4
54
244
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
13.7
7.4
12
9
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.6
7.4
24
69
E86
ICD-10 Finland
Volume depletion
7.0
7.4
17
25
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
2.7
7.4
41
163
JN6DR
NOMESCO Finland
PET-CT of whole body metabolism
11.1
7.3
13
12
X58
ICD-10 Finland
Exposure to other specified factors
2.1
7.3
78
413
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
6.4
7.3
18
29
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
7.3
7
*
D84.19
ICD-10 Finland
Unspecified defect in the complement system
+∞
7.3
7
*
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
+∞
7.3
7
*
3XA02, ,
NOMESCO Finland
+∞
7.3
7
*
R50.0
ICD-10 Finland
Fever with chills
+∞
7.3
7
*
D84.8
ICD-10 Finland
Other specified immunodeficiencies
+∞
7.3
7
*
132
Kela drug reimbursment
Sarcoidosis
+∞
7.3
7
*
D80.5
ICD-10 Finland
Immunodeficiency with increased immunoglobulin M [IgM]
+∞
7.3
7
*
J01XB01
ATC
colistin; inhalant, parenteral
+∞
7.3
7
*
D86.1
ICD-10 Finland
Sarcoidosis of lymph nodes
+∞
7.3
7
*
4AA24, ,
NOMESCO Finland
+∞
7.3
7
*
H66.9
ICD-10 Finland
Otitis media, unspecified
2.7
7.3
40
158
R01AC01
ATC
cromoglicic acid; nasal
3.3
7.3
27
85
R1250
NOMESCO Finland
Evaluation of functional capability
4.1
7.2
20
51
J01MA01
ATC
ofloxacin; systemic
2.7
7.2
40
159
J11.1
ICD-10 Finland
Influenza with other respiratory manifestations, virus not identified
4.2
7.2
19
47
A05AA02
ATC
ursodeoxycholic acid; oral
5.8
7.2
19
34
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.3
7.1
59
282
R60.0
ICD-10 Finland
Localized oedema
2.3
7.1
60
289
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
12.3
7.1
12
10
M13.9
ICD-10 Finland
Arthritis, unspecified
2.6
7.1
42
172
D50.8
ICD-10 Finland
Other iron deficiency anaemias
9.0
7.1
14
16
H53.1
ICD-10 Finland
Subjective visual disturbances
2.6
7.1
41
166
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.5
7.1
45
191
XFP96
NOMESCO Finland
Other intraoperative electrophysiological investigation in arhythmia or disturbance of impulse propagation
7.2
7.1
16
23
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
4.5
7.0
17
39
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.1
7.0
79
427
RD210, ,
NOMESCO Finland
6.5
7.0
17
27
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
6.0
7.0
18
31
N03AX11
ATC
topiramate; oral
3.7
7.0
22
62
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
7.0
158
1072
NF1AA
NOMESCO Finland
Hip X-ray examination
2.6
6.9
41
168
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
14.1
6.9
11
8
SPAT1229
SPAT
Assessment of need for aid
2.9
6.9
32
115
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.7
6.9
39
156
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.7
6.9
38
150
R60.9
ICD-10 Finland
Oedema, unspecified
3.0
6.9
30
104
JN4CD
NOMESCO Finland
Very extensive body CT
3.9
6.9
20
53
M35.7
ICD-10 Finland
Hypermobility syndrome
6.9
6.9
16
24
I80.8
ICD-10 Finland
Phlebitis and thrombophlebitis of other sites
6.9
6.9
16
24
J01DA09
ATC
[U] cefadroxil
1.8
6.9
119
744
SAA03
NOMESCO Finland
Extended examination of mouth
1.7
6.8
180
1272
J40
ICD-10 Finland
Bronchitis, not specified as acute or chronic
3.8
6.8
21
58
WX730
NOMESCO Finland
Conventional respirator
9.5
6.8
13
14
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
4.4
6.8
17
40
ZXD20
NOMESCO Finland
Day surgery
2.2
6.8
64
323
GD1BG
NOMESCO Finland
MRI of lungs and pleura with high intensity magnet
40.7
6.8
8
*
L01AA02
ATC
chlorambucil; oral
40.7
6.8
8
*
DPA20
NOMESCO Finland
Trephine of frontal sinus
40.7
6.8
8
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
40.7
6.8
8
*
212
Kela drug reimbursment
Gout
7.4
6.8
15
21
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
2.2
6.7
58
282
R04.0
ICD-10 Finland
Epistaxis
2.7
6.7
38
152
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
3.8
6.7
20
54
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.9
6.7
32
117
N03AX14
ATC
levetiracetam; systemic
4.1
6.7
18
45
R05CA10
ATC
expectorants - combinations
5.7
6.7
18
33
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
8.0
6.7
14
18
ZY010, ,
SPAT
8.0
6.7
14
18
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
8.0
6.7
14
18
M01CB01
ATC
sodium aurothiomalate; parenteral
12.5
6.6
11
9
4222
FHL
Endonasal etmoidectomy
12.5
6.6
11
9
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
7.0
6.6
15
22
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.5
6.6
42
179
R33
ICD-10 Finland
Retention of urine
2.9
6.5
31
113
R06AX22
ATC
ebastine; oral
2.0
6.5
84
476
R01BA51
ATC
phenylpropanolamine, combinations; oral
2.2
6.5
58
286
J00
ICD-10 Finland
Acute nasopharyngitis [common cold]
4.0
6.5
18
46
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.5
6.5
42
180
N30.0
ICD-10 Finland
Acute cystitis
2.0
6.5
77
424
B01AB04
ATC
dalteparin; parenteral
3.2
6.5
26
86
H02AB02
ATC
dexamethasone; systemic
2.2
6.5
59
294
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
70.9
6.4
7
*
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
70.9
6.4
7
*
372
Kela drug reimbursment
Idelalisib
70.9
6.4
7
*
C81.9
ICD-10 Finland
Hodgkin lymphoma, unspecified
70.9
6.4
7
*
L01EL01
ATC
ibrutinib; oral
70.9
6.4
7
*
PJD42
NOMESCO Finland
Excision of axillary lymph nodes
14.6
6.4
10
7
A06AC51
ATC
ispaghula, combinations; oral
3.1
6.4
27
92
J33.8
ICD-10 Finland
Other polyp of sinus
5.3
6.4
18
35
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
3.7
6.4
20
56
M05BB03
ATC
alendronic acid and colecalciferol; oral
6.7
6.4
15
23
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
8.3
6.4
13
16
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
5.7
6.4
17
31
R49.01
ICD-10 Finland
Functional dysphonia
3.5
6.4
22
66
N02BE01
ATC
paracetamol; systemic, rectal
2.4
6.4
375
3329
A49.8
ICD-10 Finland
Other bacterial infections of unspecified site
11.3
6.3
11
10
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
11.3
6.3
11
10
N17.8
ICD-10 Finland
Other acute renal failure
11.3
6.3
11
10
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
9.5
6.3
12
13
L04AD02
ATC
tacrolimus; systemic
9.5
6.3
12
13
R05CB01
ATC
acetylcysteine; inhalant, oral
9.5
6.3
12
13
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.3
6.3
49
228
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
6.3
54
262
SPAT1254
SPAT
Administration of medicine
2.1
6.3
61
311
C83.1
ICD-10 Finland
Mantle cell lymphoma
18.4
6.3
9
5
L01XX52
ATC
venetoclax; oral
18.4
6.3
9
5
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
18.4
6.3
9
5
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
18.4
6.3
9
5
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
18.4
6.3
9
5
127
Kela drug reimbursment
Transplant complication
7.2
6.3
14
20
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
7.2
6.3
14
20
27510
ICD-8 Finland
Plasma protein abnormalities, Hypogammaglobulinaemia
+∞
6.3
6
*
JK3MN
NOMESCO Finland
Bile absorbtion isotope examination
+∞
6.3
6
*
2790B
ICD-9 Finland
Disorders involving the immune mechanism, Deficiency of humoral immunity[DEFICIENTIA IMMUNOGLOBULINI A]
+∞
6.3
6
*
2790D
ICD-9 Finland
Disorders involving the immune mechanism, Deficiency of humoral immunity[COMMON VARIABLE HYPOGAMMAGLOBULINEMIA]
+∞
6.3
6
*
D81.9
ICD-10 Finland
Combined immunodeficiency, unspecified
+∞
6.3
6
*
2790A
ICD-9 Finland
Disorders involving the immune mechanism, Deficiency of humoral immunity[AGAMMAGLOBULINAEMIA (BRUTON)]
+∞
6.3
6
*
N06AX21
ATC
duloxetine; oral
2.1
6.3
63
326
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
27.1
6.2
8
*
GX2D5
NOMESCO Finland
Sleep oximetry
27.1
6.2
8
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.4
6.2
44
196
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
3.6
6.2
20
57
UJD02
NOMESCO Finland
Gastroscopy
3.1
6.2
26
88
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.8
6.2
32
122
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.7
6.2
34
134
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
5.9
6.2
16
28
R04
ICPC
Breathing problem other
3.0
6.2
27
94
K08.3
ICD-10 Finland
Retained dental root
2.5
6.2
38
159
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.2
6.1
52
251
TQW80
NOMESCO Finland
Local dermatologic skincare
4.2
6.1
16
39
R03BC03
ATC
nedocromil; inhalant
2.6
6.1
36
147
GX1E5
NOMESCO Finland
Flow volume spirometry and bronchodilation test
12.8
6.1
10
8
J12.8
ICD-10 Finland
Other viral pneumonia
12.8
6.1
10
8
NJ3CG
NOMESCO Finland
Extensive MRI examination of extremities with median high magnet
12.8
6.1
10
8
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.9
6.1
29
106
R02
ICPC
Shortness of breath/dyspnoea
2.1
6.1
61
315
A01
ICPC
Pain general/multiple sites
2.2
6.1
53
259
M01AE03
ATC
ketoprofen; systemic, rectal
1.7
6.1
150
1034
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
10.2
6.1
11
11
WX725
NOMESCO Finland
Noninvasive ventilation
2.8
6.0
31
118
R53
ICD-10 Finland
Malaise and fatigue
1.8
6.0
113
720

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
173
29
102.11
307.65
2.6
1.5
1208.72
1461.26
e6/l
0.68
149
23
305
258
42.67
307.65
5.9
1.6
0.93
1.44
g/l
2.07
268
240
131
24
79.56
239.46
2.8
1.7
217.58
206.47
e6/l
0.11
107
19
134
28
70.44
238.90
2.2
1.7
39.89
39.79
%
0.01
118
28
128
24
76.92
232.76
2.6
1.5
542.90
741.29
e6/l
0.55
101
17
124
34
51.74
206.81
2.4
1.4
—
—
—
0
0
124
35
50.25
205.23
2.3
1.4
1.57
3.13
g/l
3.60
96
25
123
35
49.67
203.06
2.3
1.4
4.20
6.56
g/l
5.03
96
26
123
35
49.67
203.06
2.3
1.4
0.23
0.36
g/l
2.18
95
25
131
66
28.64
178.31
2.3
1.9
0.21
0.79
g/l
1.98
102
56
93
19
62.93
164.53
3.2
1.4
13.69
11.68
u/l
0.81
93
19
316
884
12.05
128.36
5.7
1.4
1.30
2.34
g/l
17.18
247
550
95
50
24.39
125.26
4.9
2.1
—
—
—
0
0
172
272
10.14
114.28
2.1
1.2
62.51
308.20
u/ml
1.66
122
254
71
27
31.56
105.39
2.7
2.4
42.02
45.09
%
0.31
52
11
168
330
7.91
89.96
5.6
2.4
0.23
0.22
g/l
0.83
162
309
265
880
6.64
80.39
11.6
4.2
—
—
—
0
0
308
1207
7.15
76.46
26.0
6.1
—
—
—
0
0
106
147
9.36
76.23
3.1
1.6
—
—
—
0
0
388
1904
18.82
75.79
28.1
6.2
0.58
0.56
e9/l
0.66
378
1627
388
1913
18.65
75.12
28.3
6.2
0.04
0.04
e9/l
1.00
377
1634
79
8
121.79
74.95
1.6
1.5
0.13
—
e9/l
—
45
0
388
1957
17.87
71.91
28.6
6.2
2.09
1.98
e9/l
0.20
381
1720
388
1974
17.58
70.70
29.0
6.5
0.16
0.19
e9/l
3.15
380
1718
183
497
5.83
67.55
3.6
2.1
—
—
—
0
0
42
13
35.86
65.76
2.3
1.3
—
—
—
0
0
95
139
8.58
64.82
3.1
1.5
0.24
0.23
g/l
0.21
89
132
353
1762
8.01
61.12
27.8
6.2
57.97
56.72
%
1.04
348
1680
82
109
9.14
60.39
3.3
1.9
1.14
1.46
ug/l
0.19
76
102
385
2112
13.56
59.44
37.2
9.8
3.89
3.94
e9/l
0.20
380
1836
140
334
5.83
58.85
11.9
4.8
0.58
0.74
%
0.51
85
100
136
319
5.87
58.19
11.8
4.7
0.59
0.46
%
0.38
80
90
62
7
104.01
57.70
2.3
1.4
31.16
30.71
%
—
62
7
141
349
5.62
56.66
7.2
3.0
2.08
1.88
%
1.05
135
321
164
462
5.24
56.63
2.6
1.5
—
—
—
0
0
120
261
6.08
55.52
6.4
3.0
76.93
74.56
e9/l
0.21
98
185
130
315
5.57
53.20
12.4
5.0
0.08
0.09
%
0.06
75
79
130
327
5.35
50.74
12.8
5.3
0.27
0.04
%
0.46
73
77
226
892
4.40
49.14
3.7
2.1
3.19
2.77
mg/l
1.97
218
769
147
420
4.89
49.03
3.0
1.6
—
—
—
0
0
106
230
5.86
48.72
3.5
2.4
—
—
—
0
0
79
133
7.11
46.87
2.9
2.1
1.40
1.51
g/l
0.38
70
124
45
36
13.91
46.81
2.2
1.3
—
—
—
0
0
111
274
5.18
43.76
4.3
2.8
61.42
67.52
g/l
10.20
106
261
49
50
10.99
43.58
2.1
1.8
—
—
—
0
0
47
46
11.40
42.99
2.5
1.5
—
—
—
0
0
47
46
11.40
42.99
2.5
1.5
—
—
—
0
0
47
46
11.40
42.99
2.5
1.5
—
—
—
0
0
47
46
11.40
42.99
2.5
1.5
—
—
—
0
0
78
153
6.06
39.48
2.6
1.6
3.24
17.08
iu/ml
—
5
5
37
0
+∞
39.19
1.3
0.0
0.25
—
iu/ml
—
20
0
54
72
8.48
39.14
1.8
1.8
—
—
—
0
0
186
757
3.66
36.23
2.2
2.0
—
—
—
0
0
161
601
3.76
35.70
9.7
3.4
0.81
0.82
mmol/l
0.85
155
571
291
1587
3.84
35.47
21.4
6.5
1.21
1.22
mmol/l
1.18
286
1474
166
640
3.67
34.92
2.1
1.6
—
—
—
0
0
309
1769
3.99
34.59
22.1
7.0
1.21
1.21
mmol/l
0.17
287
1534
63
115
6.29
34.15
1.5
1.4
339.52
298.29
ug/g
0.78
44
67
137
479
3.79
33.17
4.0
3.1
3.37
4.61
e9/l
1.76
122
424
298
1697
3.73
32.92
5.6
2.5
79.49
77.12
nmol/l
0.80
288
1534
152
581
3.56
31.97
2.0
1.4
716.13
552.12
titre
0.45
31
132
119
387
3.92
31.90
4.2
2.0
303.76
381.35
nmol/l
3.27
112
358
107
323
4.12
31.85
1.6
1.5
—
—
—
0
0
198
896
3.33
31.61
17.4
4.7
—
—
—
0
0
32
28
12.31
31.28
1.3
1.1
—
—
—
0
0
142
528
3.58
31.06
2.8
2.5
205.89
103.74
ug/g
1.82
122
426
49
76
7.18
30.98
1.4
1.4
—
—
—
0
0
64
131
5.60
30.67
1.4
1.3
—
—
—
0
0
36
39
10.02
30.47
3.6
2.8
—
—
—
0
0
36
40
9.77
29.90
1.9
1.1
—
—
—
0
0
289
1675
3.43
29.70
35.1
10.7
0.00
0.00
e9/l
0.57
263
1360
221
1109
3.14
28.89
18.9
6.2
—
—
—
0
0
220
1104
3.13
28.71
9.9
3.6
7.40
7.40
ph
0.31
162
770
132
494
3.46
28.24
1.9
1.6
—
—
—
0
0
49
86
6.33
27.47
8.6
3.0
54.35
58.32
%
0.87
49
86
30
29
11.08
27.43
1.6
1.0
—
—
—
0
0
33
39
9.11
26.11
7.2
3.6
—
—
—
0
0
44
73
6.63
26.03
1.4
1.4
119.30
161.56
au/ml
—
10
24
292
1796
3.15
25.25
5.2
3.0
190.34
102.45
ug/l
3.32
284
1683
320
2093
3.37
24.47
14.6
5.1
6.75
6.54
mmol/l
0.55
310
1989
77
220
4.07
24.31
8.2
3.5
7.41
7.42
ph
0.06
64
188
78
226
4.02
24.15
8.3
3.5
5.14
5.18
kpa
0.14
73
221
193
969
2.87
24.06
4.5
3.0
1461.23
892.00
ng/l
0.87
182
801
52
110
5.27
23.86
1.4
1.2
51.43
87.50
titre
—
7
12
111
410
3.34
23.83
4.0
1.4
—
—
—
0
0
94
314
3.58
23.63
2.3
1.4
—
—
—
0
0
29
34
9.10
23.04
1.6
1.1
0.63
0.41
u/ml
0.19
20
17
117
464
3.13
22.13
18.9
7.2
103.72
104.27
mmol/l
0.61
117
464
256
1533
2.77
22.02
18.5
10.1
1.16
1.16
inr
0.01
209
1249
73
215
3.91
22.00
2.2
1.3
—
—
—
0
0
47
98
5.28
21.87
4.0
3.4
4.45
2.11
ratio
0.51
33
56
82
264
3.63
21.68
6.0
3.5
73.87
74.64
ng/l
0.04
77
235
181
917
2.74
21.65
8.4
2.7
331.55
334.31
umol/l
0.13
172
821
49
108
5.01
21.40
4.6
3.8
26.70
28.02
mg/l
0.06
40
96
49
108
5.01
21.40
4.6
3.8
32.22
97.29
mg/l
0.65
40
97
62
166
4.22
21.26
13.2
7.9
—
—
—
0
0
42
82
5.59
20.99
2.8
2.3
132.94
130.34
g/l
0.14
16
65
93
332
3.33
20.88
17.3
3.6
7.37
7.39
ph
1.22
57
185
231
1344
2.64
20.57
7.9
3.2
41.32
31.44
u/l
0.79
225
1276
90
319
3.33
20.41
17.1
3.5
1.72
2.00
mmol/l
0.31
83
279
66
193
3.88
20.01
3.1
2.0
7.52
5.54
iu/ml
0.36
24
39
106
419
3.06
19.97
5.5
3.0
7.17
7.29
umol/l
0.02
95
365
48
113
4.68
19.34
4.5
4.1
487.00
216.19
mg/l
0.94
34
52
167
853
2.61
19.15
3.1
1.7
1.35
1.19
mg/l
0.14
144
675
25
31
8.52
18.96
1.3
1.2
—
—
—
0
0
154
760
2.64
18.91
5.9
2.6
4.90
5.83
e6/l
0.50
146
695
94
358
3.11
18.79
15.0
10.7
0.50
1.02
mmol/l
0.43
74
305
52
134
4.30
18.68
1.4
1.3
—
—
—
0
0
85
306
3.24
18.68
21.3
9.7
—
—
—
0
0
52
135
4.26
18.50
1.8
1.3
1.93
2.68
u/ml
0.35
15
17
88
327
3.15
18.32
15.4
11.1
94.94
95.52
%
0.45
80
320
94
364
3.05
18.22
14.9
10.5
10.80
12.35
kpa
2.85
85
353
94
364
3.05
18.22
14.9
10.6
5.04
5.18
kpa
0.56
86
351
180
975
2.50
17.99
7.0
3.0
0.23
0.47
e6/l
1.13
150
685
51
135
4.17
17.67
1.8
1.3
1.72
6.17
u/ml
0.83
16
28
93
364
3.01
17.65
15.4
10.6
7.43
7.42
ph
0.69
42
196
201
1156
2.44
17.49
5.5
2.3
—
—
—
0
0
199
1140
2.44
17.46
7.4
3.1
111.47
41.84
e6/l
0.40
167
849
37
77
5.18
17.19
1.4
1.3
225.91
245.01
u/ml
0.14
23
43
42
98
4.66
17.07
2.9
2.7
2.94
1.95
index
0.21
16
55
136
659
2.59
17.06
5.9
2.8
505.28
528.77
mosm/kgh2o
0.72
131
578
250
1607
2.41
16.64
5.6
3.2
6.28
6.19
ph
0.54
114
906
55
162
3.76
16.41
1.6
1.2
2.41
4.47
u/ml
—
15
6
30
54
5.91
16.26
2.0
1.3
42.60
98.12
u/ml
—
6
6
25
38
6.94
15.93
1.2
1.3
—
—
—
0
0
34
71
5.13
15.72
1.2
1.1
—
—
—
0
0
190
1108
2.33
15.52
4.3
2.1
109.59
233.79
u/l
1.37
184
1059
37
85
4.68
15.30
1.4
1.2
2.59
14.49
e6/l
0.70
29
59
216
1338
2.29
15.19
8.7
3.7
51.56
54.59
e6/l
0.06
170
905
319
2339
2.61
15.13
10.0
4.3
69.00
901.77
e6/l
—
5
40
111
515
2.58
15.00
2.0
1.6
1337.29
1201.83
nmol/l
0.85
97
386
37
87
4.57
14.87
1.4
1.3
47.13
101.40
e6/l
0.31
32
63
52
158
3.62
14.79
9.5
3.7
—
—
—
0
0
331
2489
2.68
14.56
10.0
4.2
—
2.71
—
0
5
25
42
6.27
14.49
2.3
2.6
15.06
26.52
iu/ml
—
5
6
284
2007
2.34
14.12
6.7
3.5
19.50
0.00
estimate
0.49
68
409
249
1672
2.24
13.95
5.7
2.7
—
—
estimate
—
0
0
235
1545
2.21
13.83
2.7
2.0
93.74
97.66
pmol/l
0.77
162
766
44
126
3.79
13.62
3.6
1.8
7.57
10.29
g/l
3.44
39
119
155
867
2.26
13.58
4.3
2.2
—
—
—
0
0
281
2001
2.27
13.36
6.8
3.5
0.00
0.00
estimate
-0.00
67
406
40
109
3.96
13.26
1.8
1.2
18.10
55.28
u/ml
0.90
13
14
283
2030
2.26
13.08
6.8
3.6
0.00
0.02
estimate
0.80
66
378
105
507
2.44
12.83
1.3
1.2
—
—
—
0
0
40
112
3.85
12.77
15.2
10.8
—
—
—
0
0
54
186
3.19
12.57
19.4
9.7
25.16
24.84
mmol/l
0.20
49
178
18
9
20.84
12.56
1.7
1.7
—
—
—
0
0
31
74
4.45
12.21
1.2
1.1
—
—
—
0
0
200
1283
2.09
11.98
7.0
3.3
2.32
2.36
mmol/l
4.24
191
1165
178
1098
2.09
11.80
7.7
3.6
0.00
0.01
estimate
0.50
65
382
20
16
13.07
11.75
1.6
2.1
—
—
—
0
0
128
700
2.20
11.54
1.8
1.7
503.92
19631314.51
pmol/l
0.50
120
596
30
73
4.35
11.53
1.5
1.4
—
—
—
0
0
20
18
11.61
11.16
3.1
1.6
88.44
63.85
ug/l
0.61
20
18
21
40
5.48
10.70
1.5
1.2
—
—
—
0
0
53
199
2.91
10.60
3.6
2.2
0.00
0.01
estimate
—
8
74
23
30
8.05
10.53
2.4
3.0
—
—
—
0
0
21
43
5.09
9.89
5.3
2.4
32.52
32.19
pg
0.11
21
43
21
45
4.86
9.40
1.1
1.3
—
—
—
0
0
15
11
14.10
9.25
8.3
5.5
32.83
50.59
%
0.98
15
11
51
202
2.74
9.22
4.4
2.5
148.77
145.34
ng/l
0.02
40
182
50
196
2.77
9.22
22.4
2.5
0.61
0.60
%
0.05
50
196
24
59
4.26
9.11
6.5
3.0
—
—
—
0
0
14
9
16.04
9.09
1.4
1.4
—
—
—
0
0
88
452
2.20
9.05
1.6
1.4
—
—
—
0
0
115
669
2.00
8.45
5.4
3.6
73.73
258.21
ng/l
1.81
88
477
191
1318
1.84
8.30
6.8
3.5
26.19
81.45
ng/l
0.62
146
860
13
9
14.86
8.25
1.5
1.4
—
—
—
0
0
17
21
8.39
8.16
1.4
1.2
0.56
0.49
ratio
—
8
8
30
95
3.33
7.98
1.5
1.2
—
—
—
0
0
72
361
2.21
7.79
2.6
2.4
34.88
29.32
u/l
0.66
65
297
11
6
18.78
7.64
2.4
3.5
—
—
—
0
0
69
348
2.18
7.34
3.4
2.1
0.00
0.04
estimate
0.49
12
83
30
102
3.09
7.12
1.2
1.2
—
—
—
0
0
16
23
7.19
7.06
2.8
3.6
662.00
1071.83
mg
0.38
16
23
17
29
6.07
6.68
1.3
1.0
—
—
—
0
0
14
19
7.59
6.46
1.0
1.1
—
—
—
0
0
9
5
18.35
6.29
1.7
1.2
—
—
—
0
0
9
5
18.35
6.29
2.1
3.8
—
—
—
0
0
94
562
1.87
6.18
6.3
2.8
3.58
3.09
e6/l
0.15
53
248
12
14
8.79
6.09
1.4
2.1
—
—
—
0
0
11
11
10.24
6.06
1.3
1.6
—
—
—
0
0
19
54
3.64
5.95
2.2
1.4
29.14
28.53
ng/l
0.02
19
54
9
6
15.29
5.93
1.3
1.8
—
—
—
0
0
14
23
6.26
5.74
1.1
1.0
—
—
—
0
0
38
165
2.44
5.71
1.3
1.3
—
—
—
0
0
12
16
7.69
5.67
1.0
1.1
1322.67
1690.31
miu/ml
0.35
12
16
9
7
13.11
5.60
1.2
1.1
—
—
—
0
0
15
28
5.52
5.59
4.4
2.8
2.10
1.72
g/24h
—
9
22
66
364
1.97
5.49
3.4
4.4
3.66
7.00
ug/l
1.40
52
297
393
3605
2.95
5.49
68.7
14.1
18.50
22.20
mg/l
2.75
385
2885
17
48
3.65
5.38
1.1
1.3
—
—
nmol/l
—
0
0
14
26
5.53
5.27
1.5
1.4
42892.86
13622.45
e6/l
—
7
11
30
124
2.53
5.01
1.6
1.4
11.70
9.40
u/l
0.30
23
101
34
151
2.36
4.88
2.6
3.4
78.55
1500.39
u/ml
0.85
29
127
18
57
3.26
4.82
1.3
1.3
—
—
—
0
0
19
63
3.11
4.73
1.2
1.2
2.33
3.54
u/ml
—
6
26
112
1563
0.61
4.68
2.8
3.1
—
—
—
0
0
7
5
14.21
4.59
2.1
1.2
—
—
—
0
0
15
36
4.28
4.56
1.3
1.2
—
—
—
0
0
15
36
4.28
4.56
1.2
1.1
—
—
—
0
0
8
8
10.17
4.53
2.9
1.4
—
—
—
0
0
60
342
1.88
4.52
1.2
1.2
—
—
—
0
0
16
49
3.36
4.51
1.9
1.3
—
—
—
0
0
23
88
2.71
4.47
29.3
11.4
1.33
1.22
mmol/l
0.31
17
76
15
45
3.42
4.36
2.2
2.0
—
—
—
0
0
12
24
5.12
4.35
2.6
2.0
—
—
—
0
0
8
9
9.04
4.29
1.1
1.0
—
—
—
0
0
7
6
11.84
4.29
1.0
1.3
—
—
—
0
0
14
34
4.23
4.25
1.1
1.1
—
—
—
0
0
39
195
2.10
4.24
2.1
1.5
0.24
0.31
mg/l
0.43
13
90
16
52
3.16
4.13
3.3
1.8
1.68
1.57
mmol/l
0.27
16
52
192
1507
1.51
4.11
7.2
3.4
0.00
0.02
estimate
1.15
59
336
135
983
1.56
4.09
1.4
1.3
0.70
1.63
u/ml
1.03
26
274
164
1247
1.52
4.07
4.8
3.3
7.31
7.69
mmol/l
0.49
157
1068
17
58
3.01
4.06
1.2
1.4
0.48
0.53
nmol/l
0.40
17
53
14
36
3.99
4.03
2.1
1.9
27.42
22.94
nmol/l
0.47
14
31
391
3651
2.39
3.90
62.8
16.2
139.40
139.77
mmol/l
2.42
391
3580
64
391
1.75
3.85
1.9
1.8
—
—
—
0
0
14
44
3.26
3.81
1.7
1.4
—
—
—
0
0
103
720
1.57
3.68
3.7
2.6
2.45
2.45
mmol/l
0.13
95
651
17
62
2.82
3.63
6.1
2.8
16.75
16.35
%
0.20
17
62
334
3606
0.61
3.55
5.0
5.0
1.44
1.49
mmol/l
1.11
320
3375
8
13
6.25
3.51
1.1
1.2
—
—
—
0
0
6
6
10.12
3.50
1.0
1.0
—
—
—
0
0
336
3620
0.61
3.48
5.1
5.1
4.62
4.75
mmol/l
1.52
324
3402
11
27
4.16
3.42
2.5
1.7
—
—
—
0
0
342
3091
1.63
3.41
64.1
17.8
14.29
13.50
%
16.60
342
3063
12
33
3.71
3.32
1.3
1.2
—
—
—
0
0
120
888
1.50
3.27
7.6
3.5
1.02
1.02
kg/l
1.45
65
581
6
7
8.67
3.27
1.0
1.0
—
—
—
0
0
39
215
1.90
3.27
1.1
1.1
—
114.00
—
0
5
7
11
6.45
3.19
2.3
3.1
0.63
0.60
mmol/l
—
7
11
26
125
2.15
3.15
1.7
1.2
—
—
—
0
0
28
139
2.09
3.14
1.1
1.4
414.02
252.40
miu/ml
—
10
70
184
1490
1.42
3.10
2.8
2.1
—
—
—
0
0
8
16
5.08
3.06
1.3
1.1
100.12
190.54
mmol/24h
—
8
16
317
3441
0.66
3.04
4.6
4.2
1.42
1.29
mmol/l
2.43
306
3205
11
31
3.62
3.01
1.2
1.1
147.09
112.39
pmol/l
0.67
11
31
49
298
1.73
3.01
7.0
3.6
—
—
—
0
0
5
5
10.10
2.98
1.6
1.0
—
—
—
0
0
5
5
10.10
2.98
3.0
1.4
48.20
36.60
umol/l
—
5
5
5
5
10.10
2.98
1.6
1.0
6.50
6.66
mg/g
—
5
5
9
22
4.16
2.89
1.4
1.4
119.22
153.09
nmol/l
—
9
22
17
71
2.45
2.84
1.6
1.4
0.28
0.29
nmol/l
0.06
12
52
32
174
1.91
2.81
2.4
2.2
—
—
—
0
0
101
743
1.48
2.80
1.5
1.3
11.86
10.72
u/ml
0.05
41
296
18
78
2.37
2.78
1.1
1.1
—
—
—
0
0
5
6
8.42
2.75
9.4
1.8
33.60
36.17
u/l
—
5
6
5
6
8.42
2.75
1.2
1.2
—
—
—
0
0
15
60
2.56
2.73
1.4
1.2
—
—
—
0
0
8
19
4.27
2.69
1.4
1.0
—
—
—
0
0
8
19
4.27
2.69
1.4
1.0
—
—
—
0
0
8
19
4.27
2.69
1.4
1.0
—
—
—
0
0
107
803
1.45
2.66
1.6
1.3
16.19
31.53
iu/ml
2.54
26
249
71
491
1.54
2.63
1.5
1.3
—
—
—
0
0
9
25
3.66
2.59
1.6
1.4
—
—
—
0
0
9
25
3.66
2.59
1.3
1.2
—
—
—
0
0
8
20
4.06
2.58
3.0
2.8
0.50
0.75
index
—
8
20
5
7
7.21
2.55
1.0
1.0
—
—
—
0
0
5
7
7.21
2.55
3.6
1.4
—
—
—
0
0
5
7
7.21
2.55
1.0
1.0
—
—
—
0
0
5
7
7.21
2.55
1.0
1.0
—
—
—
0
0
345
3657
0.65
2.49
5.7
5.7
2.63
2.80
mmol/l
2.85
331
3425
11
38
2.95
2.43
2.6
1.6
90.91
90.29
%
0.20
11
38
9
27
3.38
2.40
1.3
1.7
0.67
3.00
u/field
—
9
16
17
78
2.23
2.34
1.1
1.1
—
—
—
0
0
24
425
0.54
2.32
1.2
1.4
—
—
—
0
0
142
1145
1.37
2.30
5.5
4.1
28.62
9.75
mg/mmol
1.19
98
698
140
1130
1.36
2.25
4.9
3.4
134.15
53.99
mg/l
1.25
94
707
5
9
5.61
2.22
3.0
1.2
—
—
—
0
0
26
146
1.83
2.12
1.8
2.1
4647.89
5730.32
u/l
—
9
55
12
50
2.44
2.04
1.2
1.3
—
—
—
0
0
14
63
2.27
2.03
1.8
1.1
115.86
13.42
iu/ml
—
7
12
9
32
2.85
2.01
1.4
1.2
—
—
—
0
0
10
39
2.60
1.95
1.4
1.1
—
—
—
0
0
9
33
2.76
1.94
1.0
1.4
—
—
—
0
0
318
2933
1.37
1.93
5.6
4.4
15.23
14.62
pmol/l
3.72
305
2707
18
327
0.53
1.91
1.7
1.8
3.34
3.54
mmol/l
0.35
13
241
41
276
1.54
1.75
1.2
1.3
—
—
—
0
0
18
96
1.91
1.73
4.1
1.8
—
—
—
0
0
28
434
0.62
1.67
1.8
1.6
—
—
—
0
0
10
41
2.47
1.65
1.6
1.4
309.40
275.89
mu/l
—
10
35
10
41
2.47
1.65
1.8
3.4
3.29
3.01
nmol/l
—
10
41
25
151
1.70
1.64
1.7
2.2
—
—
—
0
0
5
14
3.60
1.62
3.2
1.3
—
—
—
0
0
134
1128
1.28
1.52
5.8
3.1
0.00
0.00
estimate
0.50
56
325
10
45
2.25
1.47
1.0
1.0
—
—
—
0
0
19
110
1.76
1.45
1.5
2.0
2.29
4.11
iu/l
—
8
42
17
95
1.82
1.45
1.9
2.8
—
—
—
0
0
10
46
2.20
1.41
2.8
6.7
7.91
6.69
mmol/l
—
10
38
5
18
2.80
1.29
2.8
2.8
23.00
29.76
umol/l
—
5
11
5
19
2.65
1.22
1.0
1.3
381.40
99.75
iu/ml
—
5
19
6
128
0.46
1.18
1.5
1.4
—
—
—
0
0
13
222
0.57
1.17
1.9
1.7
—
—
—
0
0
34
244
1.43
1.12
2.0
2.7
65.15
45.17
u/ml
0.44
34
237
393
3836
1.53
1.02
68.5
18.1
81.03
73.44
umol/l
2.61
393
3798
59
472
1.29
1.00
1.5
1.5
—
—
—
0
0
20
134
1.52
0.93
2.7
3.1
—
—
—
0
0
26
186
1.42
0.89
1.7
2.1
—
—
—
0
0
26
187
1.42
0.87
1.7
2.1
—
—
—
0
0
26
187
1.42
0.87
1.7
2.1
—
—
—
0
0
384
3750
1.35
0.79
45.0
12.3
—
—
—
0
0
24
176
1.39
0.74
1.7
2.2
—
—
—
0
0
7
38
1.86
0.74
3.0
2.6
4.13
3.91
mmol/l
—
7
38
7
38
1.86
0.74
3.0
2.6
103.14
105.63
mmol/l
—
7
38
7
38
1.86
0.74
2.0
2.3
10.29
11.47
%
—
7
38
25
187
1.36
0.70
1.7
1.9
—
—
—
0
0
12
77
1.58
0.69
2.5
2.7
313.26
91.64
ug/min
—
7
48
21
153
1.39
0.68
1.5
1.8
—
—
—
0
0
5
30
1.67
0.61
1.2
2.8
—
—
—
0
0
10
65
1.55
0.56
1.0
1.1
—
—
—
0
0
6
38
1.59
0.54
3.3
2.6
1.19
1.19
mmol/l
—
6
38
11
74
1.50
0.54
3.7
2.9
7.35
7.86
pmol/l
0.09
11
74
10
66
1.53
0.53
3.4
1.9
—
—
—
0
0
23
180
1.29
0.51
1.1
1.1
—
—
—
0
0
349
3406
1.16
0.48
7.0
5.4
1.94
1.87
mu/l
0.55
340
3173
15
111
1.36
0.47
2.0
2.7
—
—
—
0
0
11
78
1.42
0.43
2.8
4.2
—
—
—
0
0
155
1648
0.90
0.43
1.9
1.9
1.44
1.38
mmol/l
0.46
137
1402
8
60
1.34
0.40
8.5
6.2
328.38
348.98
umol/l
—
8
54
113
1046
1.11
0.40
1.7
1.5
—
—
—
0
0
345
3510
0.89
0.33
5.8
4.9
5.87
5.86
mmol/l
0.02
335
3265
34
300
1.15
0.27
1.4
1.2
63.55
151.38
u/ml
1.78
17
124
8
65
1.24
0.27
1.4
1.5
35.40
24.32
u/l
—
8
55
393
3960
0.84
0.26
84.8
21.9
128.70
136.17
g/l
16.49
393
3919
5
40
1.25
0.22
3.6
4.0
—
39.82
—
0
13
5
41
1.22
0.22
2.2
1.2
—
—
—
0
0
393
3957
0.85
0.22
86.2
22.2
38.92
40.71
%
10.55
393
3916
393
3957
0.85
0.22
83.5
21.7
30.08
30.28
pg
1.12
393
3918
0
10
0.00
0.21
0.0
1.3
—
1.81
—
0
10
26
292
0.88
0.20
3.5
2.0
6.11
6.16
ph
0.10
19
193
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
393
3955
0.86
0.19
83.6
21.7
90.86
90.83
fl
0.03
393
3916
8
68
1.18
0.16
1.5
1.6
—
—
—
0
0
8
70
1.15
0.16
1.5
1.7
—
—
—
0
0
12
102
1.18
0.15
1.2
1.8
200.42
227.84
pmol/l
0.42
12
94
338
3414
0.94
0.14
6.9
6.0
39.23
38.72
mmol/mol
0.39
328
3224
14
157
0.89
0.11
1.4
1.2
0.88
0.93
g/l
0.30
14
157
81
835
0.96
0.09
4.5
4.7
2.16
2.07
ug/l
0.07
76
751
5
60
0.83
0.08
1.2
1.5
—
—
—
0
0
14
153
0.91
0.07
1.4
1.1
1.65
1.54
g/l
0.86
14
153
9
85
1.06
0.07
1.4
1.3
—
—
—
0
0
14
151
0.92
0.05
1.8
1.6
15.29
10.27
u/ml
—
7
33
50
507
0.98
0.01
3.0
2.9
0.70
0.71
ug/l
0.00
38
300
23
236
0.97
0.00
1.1
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
6.96
—
0
5
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.6
—
163.11
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
48.00
—
0
6

Mortality – FinRegistry

Association

Association between endpoint D3_NONHEREDHYPOGAMMA and mortality.

Females

Parameter HR [95% CI] p-value
D3_NONHEREDHYPOGAMMA 3.869 [3.03, 4.95] < 0.001
Birth year 0.991 [0.98, 1.0] 0.063

During the follow-up period (1.1.1998 — 31.12.2019), 147 out of 714 females with D3_NONHEREDHYPOGAMMA died.

Males

Parameter HR [95% CI] p-value
D3_NONHEREDHYPOGAMMA 3.065 [2.24, 4.19] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 99 out of 457 males with D3_NONHEREDHYPOGAMMA died.

Mortality risk

Mortality risk for people of age

years, who have D3_NONHEREDHYPOGAMMA.

N-year risk Females Males
1 0.361% 0.457%
5 2.14% 3.087%
10 5.093% 8.232%
15 9.046% 16.041%
20 15.845% 25.789%

Relationships between endpoints

Index endpoint: D3_NONHEREDHYPOGAMMA – Nonhereditary hypogammaglobulinemia

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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