COPD related to chronic (opportunist) infections

COPD_OPPORTUNIST_INFECTIONS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

  • J10_COPDNAS
28291

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

1018

6. Filter based on genotype QC (FinnGen only)

903

Control definitions (FinnGen only)

Control conditions
not J10_COPDNAS

Extra metadata

First used in FinnGen datafreeze
DF3

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5779 2148 3513
Only index persons 4088 1704 2384
Unadjusted period prevalence (%)
Whole population 0.09 0.06 0.10
Only index persons 0.08 0.06 0.09
Median age at first event (years)
Whole population 66.31 65.05 67.09
Only index persons 66.29 65.07 67.17

-FinnGen-

Key figures

All Female Male
Number of individuals 903 324 579
Unadjusted period prevalence (%) 0.21 0.12 0.27
Median age at first event (years) 67.20 62.70 69.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
928
Matched controls
9280
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J45.9
ICD-10 Finland
Asthma, unspecified
11.5
320.9
517
913
J01MA14
ATC
moxifloxacin; systemic
13.4
310.7
369
436
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
592.0
308.9
290
7
R03DA04
ATC
theophylline; systemic, rectal
26.5
307.7
340
198
R03AK06
ATC
salmeterol and fluticasone; inhalant
21.4
307.7
551
593
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
24.9
307.7
662
843
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
675.5
307.7
793
80
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
448.9
307.7
479
22
R03AK03
ATC
[U] fenoterol and ipratropium bromide
20.9
307.7
285
193
J47
ICD-10 Finland
Bronchiectasis
574.7
307.7
761
73
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
164.6
307.7
323
30
UGC12
NOMESCO Finland
Flexible bronchoscopy
13.9
307.7
384
447
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
43.2
307.7
222
67
R03BB04
ATC
tiotropium bromide; inhalant
69.8
307.7
658
313
R03AC12
ATC
salmeterol; inhalant
22.2
307.5
247
149
R95
ICPC
Chron obstructive pulmonary disease
47.6
297.8
178
46
J45.1
ICD-10 Finland
Nonallergic asthma
15.5
289.7
292
267
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
16.2
275.7
265
223
J96.1
ICD-10 Finland
Chronic respiratory failure
43.1
272.8
167
47
J18.9
ICD-10 Finland
Pneumonia, unspecified
11.5
270.9
717
2123
R03BB01
ATC
ipratropium bromide; inhalant
17.4
250.4
226
169
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
9.8
241.7
365
574
H02AB06
ATC
prednisolone; systemic
14.3
230.6
814
3092
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
9.2
228.2
366
614
R03AC02
ATC
salbutamol; inhalant
14.2
227.0
815
3132
J46
ICD-10 Finland
Status asthmaticus
29.4
211.4
145
58
R03BA05
ATC
fluticasone; inhalant
7.8
204.9
397
809
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
51.3
201.2
117
26
R03DC03
ATC
montelukast; oral
8.1
197.6
351
650
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
103.2
179.7
93
10
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
47.7
179.5
106
25
J45.8
ICD-10 Finland
Mixed asthma
21.7
175.7
136
73
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
6.4
169.3
416
1045
R03BA01
ATC
beclometasone; inhalant
7.0
159.7
310
617
J45.0
ICD-10 Finland
Predominantly allergic asthma
9.3
157.6
216
292
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
15.8
156.0
142
105
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
230.3
153.0
154
8
J01MA12
ATC
levofloxacin; systemic
5.6
147.3
431
1241
H02AB07
ATC
prednisone; oral
6.2
143.2
320
723
R03BA02
ATC
budesonide; inhalant
6.0
142.7
341
819
R03AK07
ATC
formoterol and budesonide; inhalant
6.0
142.3
338
807
R03AC13
ATC
formoterol; inhalant
11.0
140.5
163
176
J43.9
ICD-10 Finland
Emphysema, unspecified
24.8
138.5
100
45
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
10.2
138.4
171
201
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
30.5
136.1
91
33
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
12.8
127.3
131
118
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
5.5
127.0
679
3080
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
28.1
126.7
87
34
R04.2
ICD-10 Finland
Haemoptysis
10.7
124.6
146
159
R03AK08
ATC
formoterol and beclometasone; inhalant
11.6
121.1
133
132
R03AC03
ATC
terbutaline; inhalant
6.0
117.7
256
555
GD1AD
NOMESCO Finland
Thorax CT examination
7.2
116.0
198
338
XG410
NOMESCO Finland
Flow-volume spirometry
10.2
115.3
139
157
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
7.8
115.2
180
279
H02AB04
ATC
methylprednisolone; systemic
5.1
104.9
282
730
J01FA06
ATC
roxithromycin; oral
4.2
100.0
559
2474
J42
ICD-10 Finland
Unspecified chronic bronchitis
26.2
94.2
66
27
R02
ICPC
Shortness of breath/dyspnoea
4.6
91.7
278
785
TGC00
NOMESCO Finland
Bronchial lavation
9.7
88.8
109
125
J45
ICD-10 Finland
Asthma
5.7
86.6
186
392
R06.0
ICD-10 Finland
Dyspnoea
3.7
85.4
451
1870
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
8.2
85.4
122
169
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.2
83.5
692
3829
J01FA09
ATC
clarithromycin; systemic
3.6
78.0
389
1537
R96
ICPC
Asthma
5.1
77.8
191
450
J01AA02
ATC
doxycycline; systemic
7.8
77.7
859
5717
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
41.2
77.2
47
12
51899
ICD-8 Finland
Bronchiectasis
165.3
73.2
76
5
R03AK11
ATC
formoterol and fluticasone; inhalant
11.4
72.5
78
74
XG466
NOMESCO Finland
Sleep oxymetry
9.6
71.0
87
99
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.5
68.5
322
1209
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
5.0
68.0
165
383
R05CB01
ATC
acetylcysteine; inhalant, oral
14.0
68.0
64
49
J01FA15
ATC
telithromycin; oral
4.8
63.6
161
386
R81
ICPC
Pneumonia
6.7
63.1
106
174
J20
ICD-10 Finland
Acute bronchitis
4.5
62.5
176
459
R03BA08
ATC
ciclesonide; inhalant
5.0
61.5
148
340
R03AL03
ATC
vilanterol and umeclidinium bromide; inhalant
21.9
61.5
46
22
C03CA01
ATC
furosemide; systemic
3.1
61.1
547
2949
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
7.2
61.0
96
147
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
5.3
60.4
135
291
R03DC01
ATC
zafirlukast; oral
13.7
60.1
57
44
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
+∞
59.0
56
*
J01FA10
ATC
azithromycin; systemic
3.0
58.8
553
3042
4940A
ICD-9 Finland
Bronchiectasis[BRONCHIECTASIAE]
130.4
57.6
61
5
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
16.3
55.8
48
31
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
8.5
53.0
71
90
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.5
51.5
223
779
R28
ICPC
Limited function/disability (R)
11.9
51.3
53
47
XG474
NOMESCO Finland
Exhalation nntrogen oxide
9.4
50.7
62
70
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
12.6
49.2
49
41
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
4.8
48.3
119
277
J40
ICD-10 Finland
Bronchitis, not specified as acute or chronic
7.6
46.7
68
95
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
6.8
46.4
76
121
A07AA02
ATC
nystatin; oral
4.5
45.9
121
297
R03BB02
ATC
oxitropium bromide; inhalant
18.1
43.0
35
20
XG405
NOMESCO Finland
Education on PEF monitoring
13.0
42.0
41
33
49300
ICD-8 Finland
Asthma, bronchiale
7.2
42.0
64
94
A01AB09
ATC
miconazole; local oral
3.7
41.4
147
447
J96.0
ICD-10 Finland
Acute respiratory failure
10.5
41.0
46
46
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
13.1
40.3
39
31
J15.8
ICD-10 Finland
Other bacterial pneumonia
15.8
40.1
35
23
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.6
39.9
326
1589
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
39.9
332
1634
R05
ICPC
Cough
2.7
38.6
293
1375
R03AL11
ATC
formoterol, glycopyrronium bromide and budesonide; inhalant
65.9
38.4
44
7
I50.9
ICD-10 Finland
Heart failure, unspecified
2.7
37.8
280
1296
J01CA04
ATC
amoxicillin; systemic
3.1
37.5
775
5761
348
Kela drug reimbursment
Roflumilast
+∞
35.6
34
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
35.5
432
2499
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
6.5
35.1
59
96
4912A
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS CHRONICA OBSTRUCTIVA]
+∞
34.6
33
*
M05BA04
ATC
alendronic acid; oral
3.3
34.4
148
507
A03
ICPC
Fever
3.0
34.3
177
674
XF400
NOMESCO Finland
ECG with 12 standard connections
2.6
34.0
249
1138
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
12.6
33.4
33
27
TDM10
NOMESCO Finland
Puncture of maxillary antrum
5.5
33.3
67
130
J18.1
ICD-10 Finland
Lobar pneumonia, unspecified
10.1
33.2
38
39
J01GB01
ATC
tobramycin; inhalant, parenteral
338.6
33.1
33
*
R01AD08
ATC
fluticasone; nasal
2.5
32.4
279
1374
WW200
NOMESCO Finland
Immunization
6.8
31.4
50
77
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
31.1
291
1483
WX725
NOMESCO Finland
Noninvasive ventilation
4.1
30.9
91
241
R03DX07
ATC
roflumilast; oral
+∞
30.4
29
*
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
6.7
30.1
49
77
R5140
NOMESCO Finland
Monitoring the use of the aid
2.9
29.2
159
620
A02BC02
ATC
pantoprazole; systemic
2.4
29.1
694
5141
R03AC18
ATC
indacaterol; inhalant
45.3
28.9
35
8
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.2
28.6
374
2178
N07BA03
ATC
varenicline; oral
6.0
28.3
51
89
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
5.1
28.2
61
126
R01AD09
ATC
mometasone; nasal
2.2
28.0
405
2450
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
27.4
356
2060
J41.1
ICD-10 Finland
Mucopurulent chronic bronchitis
42.6
26.9
33
8
A02BC05
ATC
esomeprazole; systemic
2.1
26.7
422
2629
Z3226
NOMESCO Finland
Physiotherapist
2.4
26.6
226
1093
J01DA08
ATC
[U] cefaclor
3.5
26.6
99
308
J01MA02
ATC
ciprofloxacin; systemic
2.1
26.2
457
2945
R03AL04
ATC
indacaterol and glycopyrronium bromide; inhalant
61.9
26.1
30
5
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
10.3
25.7
29
29
R06AE07
ATC
cetirizine; oral
2.1
25.7
385
2341
J01DA06
ATC
[U] cefuroxime
2.6
25.5
168
720
A02BC03
ATC
lansoprazole; oral
2.1
25.4
334
1931
R03BB07
ATC
umeclidinium bromide; inhalant
36.8
25.3
32
9
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
+∞
25.1
24
*
R29
ICPC
Respiratory symptom/complaint other
3.5
24.5
91
282
R06.2
ICD-10 Finland
Wheezing
4.3
23.9
63
153
R05DA20
ATC
opium alkaloids and derivatives - combinations
2.2
23.7
269
1461
J15.1
ICD-10 Finland
Pneumonia due to Pseudomonas
42.6
23.7
29
7
R05
ICD-10 Finland
Cough
2.3
23.7
232
1188
N02AX02
ATC
tramadol; systemic, rectal
2.0
23.3
460
3060
J01DA01
ATC
[U] cefalexin
2.0
23.0
597
4360
J01DB01
ATC
cefalexin; oral
2.4
23.0
758
6064
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
4.1
22.9
66
172
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.5
22.8
57
133
SPAT1254
SPAT
Administration of medicine
2.3
22.6
201
985
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
7.2
22.6
34
49
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
4.2
22.5
62
156
R01AD01
ATC
beclometasone; nasal
2.5
22.4
160
710
C07AB07
ATC
bisoprolol; oral
2.0
22.4
583
4243
Z2446
NOMESCO Finland
Social worker
3.4
22.4
85
267
J01DC02
ATC
cefuroxime; systemic
3.9
22.0
68
186
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
21.7
176
827
R78
ICPC
Acute bronchitis/bronchiolitis
5.4
21.4
43
83
50301
ICD-8 Finland
Chronic sinusitis, Maxillaris NUD
7.4
21.3
31
43
A02BA02
ATC
ranitidine; systemic
2.1
21.2
246
1341
J31.0
ICD-10 Finland
Chronic rhinitis
3.1
20.9
94
327
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.2
20.7
87
291
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.1
20.7
91
313
XG460
NOMESCO Finland
Short time oxymetry
6.1
20.5
36
61
WX892
NOMESCO Finland
Monitored bed care
2.8
20.5
112
434
Z3231
NOMESCO Finland
Registered nurse
2.0
20.5
301
1785
Z72.0
ICD-10 Finland
Tobacco use
6.5
20.2
33
52
A02BC01
ATC
omeprazole; systemic
2.0
20.2
307
1842
R50.9
ICD-10 Finland
Fever, unspecified
2.3
20.1
186
924
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
20.0
197
1003
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
29.7
19.7
26
9
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
107.3
19.6
21
*
H02AB09
ATC
hydrocortisone; systemic
4.9
19.6
44
94
N05CF01
ATC
zopiclone; oral
1.9
19.3
356
2275
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
19.2
243
1361
I50.0
ICD-10 Finland
Congestive heart failure
2.5
18.9
135
597
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.1
18.9
85
296
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
4.6
18.9
45
101
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.1
18.6
84
293
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
18.5
172
853
R05FB02
ATC
cough suppressants and expectorants; systemic
1.9
18.4
390
2595
N02AA05
ATC
oxycodone; systemic
2.0
18.2
258
1501
R74
ICPC
Upper respiratory infection acute
2.0
17.9
225
1254
A01AB10
ATC
natamycin; local oral
4.4
17.8
45
106
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
4.1
17.7
50
128
R4110
NOMESCO Finland
Physiotherapy
1.9
17.7
292
1787
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
5.9
17.7
32
56
J02AC01
ATC
fluconazole; systemic
1.9
17.7
296
1821
E88.0
ICD-10 Finland
Disorders of plasma-protein metabolism, not elsewhere classified
96.9
17.6
19
*
F17.20
ICD-10 Finland
Addiction relationship caused by tobacco addiction relationship currently independent
29.4
17.5
23
8
J43.8
ICD-10 Finland
Other emphysema
21.4
17.4
25
12
1240
FHL
Bronchoscopy
5.6
17.2
33
61
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.1
17.2
185
971
A01AB04
ATC
amphotericin B; local oral
3.2
17.1
69
225
R03BB06
ATC
glycopyrronium bromide; inhalant
32.1
17.1
22
7
N03AX16
ATC
[U] pregabalin
2.0
16.8
237
1373
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
5.6
16.8
32
59
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
4.3
16.2
42
101
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
30.6
16.2
21
7
49109
ICD-8 Finland
Chronic bronchitis, Unspecified
30.6
16.2
21
7
R99
ICPC
Respiratory disease other
5.1
16.0
34
69
N02AA01
ATC
morphine; systemic, rectal
4.1
16.0
45
115
M05BB03
ATC
alendronic acid and colecalciferol; oral
4.4
15.8
40
94
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.9
15.8
237
1397
J01DA09
ATC
[U] cefadroxil
1.9
15.7
243
1447
J01FF01
ATC
clindamycin; systemic
1.9
15.6
266
1634
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
15.3
156
799
FB1AD
NOMESCO Finland
CT examination of arteria pulmonalis
4.1
15.3
43
110
J43.2
ICD-10 Finland
Centrilobular emphysema
23.8
15.2
21
9
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
12.1
15.1
27
23
R01AD58
ATC
fluticasone, combinations; nasal
2.1
14.9
169
902
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
11.6
14.8
27
24
XQ800
NOMESCO Finland
Prick test
3.1
14.8
62
207
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.2
14.7
145
733
J37.0
ICD-10 Finland
Chronic laryngitis
3.8
14.7
46
127
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
81.4
14.6
16
*
SPAT1263
SPAT
Sampling
1.7
14.5
391
2742
R05CB03
ATC
carbocisteine; oral
4.3
14.5
38
92
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.4
14.5
111
505
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
14.4
304
1986
R03DA54
ATC
theophylline, combinations excl. psycholeptics; systemic
6.1
14.4
25
42
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
3.3
14.2
55
175
R01AD05
ATC
budesonide; nasal
2.7
14.1
80
315
A31.9
ICD-10 Finland
Mycobacterial infection, unspecified
43.2
14.1
17
*
A46
ICD-10 Finland
Erysipelas
2.0
14.1
176
970
R01BA52
ATC
pseudoephedrine, combinations; oral
1.8
14.1
252
1565
G47.3
ICD-10 Finland
Sleep apnoea
1.9
14.1
213
1254
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
14.1
170
927
J86.9
ICD-10 Finland
Pyothorax without fistula
6.1
13.9
24
40
T08
ICPC
Weight loss
4.6
13.9
33
74
N06AB04
ATC
citalopram; systemic
1.9
13.8
194
1115
XF600
NOMESCO Finland
Bloodpressure measurement
2.6
13.7
83
338
J61
ICD-10 Finland
Pneumoconiosis due to asbestos and other mineral fibres
6.6
13.7
22
34
SPAT1059
SPAT
Spirometry at the office
3.0
13.7
63
222
SPAT1325
SPAT
Vaccination
1.7
13.7
367
2561
R03BB05
ATC
aclidinium bromide; inhalant
34.6
13.5
17
5
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.9
13.5
63
224
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.9
13.5
66
241
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.9
13.4
64
230
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
4.2
13.4
36
89
L04AX01
ATC
azathioprine; systemic
3.6
13.3
45
131
R03CC02
ATC
salbutamol; systemic
4.2
13.3
35
85
S81.0
ICD-10 Finland
Open wound of knee
5.4
13.3
26
49
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.7
13.2
333
2278
WX722
NOMESCO Finland
PEEP
2.8
13.2
66
244
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
5.6
13.1
25
46
JN3AD
NOMESCO Finland
Abdominal CT examination
2.1
13.1
144
757
A02BA03
ATC
famotidine; systemic
3.0
13.0
59
206
C03DA01
ATC
spironolactone; oral
2.0
13.0
159
869
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
19.4
12.9
19
10
R05FA02
ATC
opium derivatives and expectorants; systemic
1.7
12.9
369
2609
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.0
12.7
56
193
WX882
NOMESCO Finland
High dependency care
3.6
12.6
42
121
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.4
12.6
90
397
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
3.7
12.5
40
112
R60.0
ICD-10 Finland
Localized oedema
2.0
12.5
153
835
J43.1
ICD-10 Finland
Panlobular emphysema
+∞
12.5
12
*
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
24.7
12.5
17
7
P01AB01
ATC
metronidazole; oral, rectal
1.7
12.5
332
2297
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.7
12.4
70
275
WZC30
NOMESCO Finland
Teaching
1.9
12.4
172
980
A28
ICPC
Limited function/disability NOS
1.8
12.2
250
1607
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
3.6
12.2
41
119
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
4.8
12.2
27
57
R03BC03
ATC
nedocromil; inhalant
2.6
12.1
75
309
J02AC03
ATC
voriconazole; systemic
18.3
12.1
18
10
ZXD05
NOMESCO Finland
Urgent procedure
1.7
12.0
284
1900
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.2
11.9
104
499
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.0
11.8
52
179
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.0
11.7
140
757
L28
ICPC
Limited function/disability (L)
1.8
11.7
238
1525
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
30.4
11.7
15
5
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.3
11.6
44
138
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
65.8
11.6
13
*
49102
ICD-8 Finland
Chronic bronchitis, Purulenta
+∞
11.5
11
*
J01XB01
ATC
colistin; inhalant, parenteral
121.5
11.4
12
*
B44.8
ICD-10 Finland
Other forms of aspergillosis
121.5
11.4
12
*
N05BA01
ATC
diazepam; systemic, rectal
2.0
11.4
132
706
B02AA02
ATC
tranexamic acid; systemic
2.1
11.4
110
550
48509
ICD-8 Finland
Bronchopneumonia, unspecified
9.8
11.3
22
23
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
2.7
11.3
60
229
Z2221
NOMESCO Finland
Medical doctor
1.7
11.2
252
1657
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.1
11.1
47
158
46100
ICD-8 Finland
Acute sinusitis, Maxillaris
5.8
11.0
20
35
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.2
11.0
97
467
F2680, ,
NOMESCO Finland
43.9
10.9
13
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.5
10.9
71
300
GX2D5
NOMESCO Finland
Sleep oximetry
15.7
10.9
17
11
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
10.8
299
2074
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
5.0
10.8
23
47
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
28.4
10.7
14
5
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
2.0
10.7
133
728
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
13.1
10.7
18
14
A06AD11
ATC
lactulose; oral
1.8
10.7
195
1208
RK320, ,
NOMESCO Finland
8.1
10.6
23
29
C08DA01
ATC
verapamil; systemic
2.7
10.6
59
231
N05BA04
ATC
oxazepam; oral
1.7
10.6
242
1597
J93.1
ICD-10 Finland
Other spontaneous pneumothorax
9.3
10.5
21
23
J98.1
ICD-10 Finland
Pulmonary collapse
10.2
10.5
20
20
R03BC01
ATC
cromoglicic acid; inhalant
5.5
10.4
20
37
N06AA09
ATC
amitriptyline; systemic
2.2
10.4
95
465
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
10.4
263
1782
49099
ICD-8 Finland
Bronchitis, unspecified
7.6
10.2
23
31
R04
ICPC
Breathing problem other
2.9
10.2
47
166
4900A
ICD-9 Finland
Bronchitis, not specified as acute or chronic[BRONCHITIS NUD]
13.3
10.2
17
13
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
10.2
185
1143
ZY010
NOMESCO Finland
Hospital outpatient
3.2
10.2
41
134
R11
ICD-10 Finland
Nausea and vomiting
2.2
10.1
91
442
N06AX11
ATC
mirtazapine; oral
1.6
10.1
293
2051
R24
ICPC
Haemoptysis
8.6
10.1
21
25
A02BA04
ATC
nizatidine; systemic
2.2
10.1
90
436
SPAT1255
SPAT
Intravenous administration of medicine
2.3
10.1
81
376
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.0
10.0
108
563
R03AC19
ATC
olodaterol
40.5
10.0
12
*
ZX120
NOMESCO Finland
Intravenous
2.1
10.0
104
535
J01DC04
ATC
cefaclor; oral
7.7
9.9
22
29
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
9.9
175
1073
120
Kela drug reimbursment
Hypogammaglobulinaemia
20.3
9.8
14
7
P17
ICPC
Tobacco abuse
10.8
9.8
18
17
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
9.7
9.8
19
20
N03AX12
ATC
[U] gabapentin; oral
1.8
9.7
158
944
49101
ICD-8 Finland
Chronic bronchitis, Nonpurulenta (simplex)
13.5
9.7
16
12
R03AL05
ATC
formoterol and aclidinium bromide; inhalant
55.6
9.7
11
*
SPAT1257
SPAT
Teaching of medicine inhalation technique
3.0
9.7
43
149
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.7
9.6
52
200
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.6
9.6
425
3273
4931A
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA SINE EXACERBATIONE]
8.5
9.6
20
24
GD1BA
NOMESCO Finland
Extensive X-ray examination of thorax
4.9
9.6
21
44
ZXA10
NOMESCO Finland
Bilateral
1.7
9.6
201
1292
R63.4
ICD-10 Finland
Abnormal weight loss
2.7
9.5
53
207
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
10.2
9.5
18
18
R13
ICD-10 Finland
Dysphagia
2.2
9.5
84
405
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.9
9.5
27
70
N05CD07
ATC
temazepam; oral
1.9
9.4
139
806
6BA02, ,
NOMESCO Finland
21.9
9.4
13
6
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.8
9.4
141
822
TPH07
NOMESCO Finland
Cathetrisation of artery
1.9
9.4
127
716
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
4.6
9.3
22
49
J32.4
ICD-10 Finland
Chronic pansinusitis
4.8
9.3
21
45
J98.0
ICD-10 Finland
Diseases of bronchus, not elsewhere classified
10.8
9.3
17
16
UJF32
NOMESCO Finland
Coloscopy
1.6
9.3
269
1875
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
9.3
179
1122
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.2
9.3
36
115
R06AX13
ATC
loratadine; oral
2.0
9.3
108
578
RK110, ,
NOMESCO Finland
7.8
9.2
20
26
R03DA05
ATC
aminophylline; systemic, rectal
7.8
9.2
20
26
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
2.5
9.2
59
248
R01AD11
ATC
triamcinolone; nasal
2.3
9.1
72
331
ZXE00
NOMESCO Finland
One hour or less
1.6
9.1
339
2503
N02BE01
ATC
paracetamol; systemic, rectal
1.8
9.1
796
7136
RK250, ,
NOMESCO Finland
9.2
9.1
18
20
R79
ICPC
Chronic bronchitis
15.8
9.0
14
9
R01AD12
ATC
fluticasone furoate; nasal
1.7
9.0
201
1312
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.0
9.0
40
139
Q32.21
ICD-10 Finland
Secondary congenital bronchomalacia
24.3
8.9
12
5
78310
ICD-8 Finland
Symptoms referable to respiratory system, Haemoptysis
12.7
8.9
15
12
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
8.1
8.9
19
24
B37.0
ICD-10 Finland
Candidal stomatitis
8.1
8.9
19
24
J01MA01
ATC
ofloxacin; systemic
2.0
8.9
100
529
J33.0
ICD-10 Finland
Polyp of nasal cavity
3.0
8.9
38
129
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
14.2
8.7
14
10
R03AK
ATC
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
14.2
8.7
14
10
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.3
8.7
64
286
C01DA14
ATC
isosorbide mononitrate; oral
1.6
8.7
230
1566
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
2.2
8.7
74
352
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.8
8.6
143
857
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
11.7
8.6
15
13
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
3.3
8.5
31
95
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
8.4
120
686
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
90.9
8.4
9
*
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
90.9
8.4
9
*
B44.0
ICD-10 Finland
Invasive pulmonary aspergillosis
90.9
8.4
9
*
R05CA10
ATC
expectorants - combinations
3.5
8.4
28
81
R03AC04
ATC
fenoterol; inhalant
10.9
8.3
15
14
J20.0
ICD-10 Finland
Acute bronchitis due to Mycoplasma pneumoniae
7.2
8.3
19
27
Z3229
NOMESCO Finland
Other healthcare associate professional
2.0
8.3
96
513
P03
ICPC
Feeling depressed
2.4
8.3
58
254
M05BX04
ATC
denosumab; parenteral
2.1
8.2
78
387
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.4
8.1
55
237
R83
ICPC
Respiratory infection other
1.8
8.1
137
826
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
33.7
8.1
10
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.4
8.1
53
225
J18
ICD-10 Finland
Pneumonia, organism unspecified
6.4
8.0
20
32
J92.9
ICD-10 Finland
Pleural plaque without asbestos
4.2
8.0
21
51
WX721
NOMESCO Finland
Oxygen concentrator therapy
22.2
8.0
11
5
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.5
8.0
48
195
C01AA05
ATC
digoxin; systemic
1.8
8.0
120
697
A08
ICPC
Swelling
2.1
8.0
72
350
A01
ICPC
Pain general/multiple sites
1.9
8.0
105
585
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
3.3
8.0
30
94
I20.90
ICD-10 Finland
Angina pectoris, unspecified
2.3
7.9
57
252
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.5
7.9
296
2174
JN4AD
NOMESCO Finland
Body CT examination
1.8
7.8
132
796
R05CB02
ATC
bromhexine; systemic
3.7
7.8
24
66
M05BA07
ATC
risedronic acid; oral
2.8
7.8
39
145
R06AE09
ATC
levocetirizine; oral
1.9
7.7
100
554
C08DB01
ATC
diltiazem; oral
2.1
7.7
73
362
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.0
7.7
88
468
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.9
7.6
100
557
JN4BD
NOMESCO Finland
Extensive body CT
1.8
7.6
117
685
J41.0
ICD-10 Finland
Simple chronic bronchitis
8.1
7.6
16
20
J20.8
ICD-10 Finland
Acute bronchitis due to other specified organisms
18.5
7.6
11
6
J01MA11
ATC
grepafloxacin; oral
25.2
7.6
10
*
B96.5
ICD-10 Finland
Pseudomonas (aeruginosa) as the cause of diseases classified to other chapters
25.2
7.6
10
*
PD3YT
NOMESCO Finland
Pelvic artery PTA with stent
4.1
7.6
20
49
B01AA03
ATC
warfarin; systemic
1.5
7.4
251
1800
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
3.3
7.4
27
83
B05XA03
ATC
sodium chloride; parenteral
80.7
7.4
8
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.3
7.3
57
261
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.0
7.3
84
447
N05BA02
ATC
chlordiazepoxide; systemic
3.2
7.3
28
89
S97
ICPC
Chronic ulcer skin
2.0
7.3
81
426
GX1E5
NOMESCO Finland
Flow volume spirometry and bronchodilation test
9.5
7.3
14
15
SPAT1060
SPAT
Administration of oxygen
9.5
7.3
14
15
4931B
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA CUM EXACERBATIONE]
9.5
7.3
14
15
P01BA02
ATC
hydroxychloroquine; oral
2.1
7.2
70
350
D07AA02
ATC
hydrocortisone; topical
1.8
7.2
110
643
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
2.8
7.2
35
128
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.0
7.2
84
450
F1246, ,
NOMESCO Finland
30.3
7.2
9
*
4919X
ICD-9 Finland
Chronic bronchitis, Unspecified chronic bronchitis
20.2
7.1
10
5
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
3.0
7.1
30
101
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
6.1
7.1
18
30
4610A
ICD-9 Finland
Acute sinusitis, Maxillary
6.1
7.1
18
30
48609
ICD-8 Finland
Pneumonia, unspecified
5.7
7.1
19
34
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.9
7.1
96
541
A41.9
ICD-10 Finland
Sepsis, unspecified
2.4
7.1
46
195
C02DE01, ,
ATC
3.9
7.0
20
52
M54.5
ICD-10 Finland
Low back pain
1.5
7.0
287
2140
SPAT1058
SPAT
PEF monitoring instruction
2.0
7.0
72
369
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
3.7
6.9
21
57
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
6.9
145
927
M01AG02
ATC
tolfenamic acid; oral, rectal
1.9
6.8
91
509
WX730
NOMESCO Finland
Conventional respirator
3.8
6.8
20
53
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
2.4
6.8
46
198
RF220, ,
NOMESCO Finland
3.7
6.8
21
58
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
40.4
6.8
8
*
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.9
6.7
31
110
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
6.7
359
2815
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
22.7
6.7
9
*
J98.9
ICD-10 Finland
Respiratory disorder, unspecified
22.7
6.7
9
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.5
6.7
39
157
WX872
NOMESCO Finland
Intensive care
2.2
6.6
58
279
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
3.3
6.6
24
74
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.6
6.6
147
954
R06AX22
ATC
ebastine; oral
1.7
6.5
117
717
N06AB10
ATC
escitalopram; oral
1.7
6.5
129
812
L14
ICPC
Leg/thigh symptom/complaint
1.9
6.5
81
444
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.9
6.5
81
444
D64.9
ICD-10 Finland
Anaemia, unspecified
1.7
6.5
136
869
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.5
6.5
260
1927
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
6.4
314
2415
GX1P5
NOMESCO Finland
Nocturnal CO2 monitoring
70.3
6.4
7
*
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
7.5
6.4
14
19
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
6.4
73
388
UJD02
NOMESCO Finland
Gastroscopy
2.2
6.4
55
263
A04
ICPC
Weakness/tiredness general
1.6
6.4
152
1002
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
2.8
6.4
30
108
N06AX12
ATC
bupropion; oral
2.7
6.4
34
131
TKC20
NOMESCO Finland
Catheterisation of bladder
1.9
6.3
83
462
UDM02
NOMESCO Finland
Sinoscopy
3.4
6.3
22
66
GX1L5
NOMESCO Finland
Exhaled nitric oxide analysis
9.3
6.3
12
13
J93.9
ICD-10 Finland
Pneumothorax, unspecified
9.3
6.3
12
13
R06AX26
ATC
fexofenadine; oral
2.3
6.3
44
193
J14
ICD-10 Finland
Pneumonia due to Haemophilus influenzae
+∞
6.3
6
*
R07.3
ICD-10 Finland
Other chest pain
1.8
6.2
100
593
SPAT1262
SPAT
Handing over of treatment supplies
1.6
6.2
172
1175
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
3.2
6.2
24
77
R23.3
ICD-10 Finland
Spontaneous ecchymoses
3.0
6.2
27
93
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
6.2
88
503
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
3.8
6.1
18
48
F41.09
ICD-10 Finland
UNS Panic Syndrome
4.2
6.1
16
39
SPAT1260
SPAT
Consultation of another employee
1.6
6.1
159
1071
J01FA01
ATC
erythromycin; systemic
1.8
6.1
85
483
RS230, ,
NOMESCO Finland
12.6
6.1
10
8
M81.4
ICD-10 Finland
Drug-induced osteoporosis
8.7
6.1
12
14
SPAT1229
SPAT
Assessment of need for aid
1.8
6.1
89
514
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.2
6.0
52
249
4221
FHL
Polyp removal from the nasal cavity, sinus puncture or irrigation, or biopsy under general anesthesia or operating room
10.1
6.0
11
11
H65.3
ICD-10 Finland
Chronic mucoid otitis media
3.5
6.0
20
58
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
6.1
6.0
15
25
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.5
6.0
35
141

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
265
115
31.85
307.65
5.5
2.4
—
—
—
0
0
113
38
33.72
173.86
2.0
1.3
2.17
1.01
u/ml
0.54
92
23
211
351
7.49
127.21
2.2
1.2
329.76
161.48
u/ml
2.27
197
321
124
142
9.92
101.47
7.4
2.3
—
—
—
0
0
292
954
4.01
77.67
2.9
1.5
—
—
—
0
0
73
57
13.82
76.75
1.5
1.3
2.75
2.75
g/l
0.00
50
44
73
57
13.82
76.75
1.5
1.3
0.42
0.45
g/l
0.10
53
43
73
57
13.82
76.75
1.5
1.3
7.12
7.03
g/l
0.05
53
44
72
57
13.61
75.07
1.6
1.3
—
—
—
0
0
52
23
23.89
71.81
5.3
2.0
—
—
—
0
0
85
106
8.73
64.52
1.6
1.4
0.84
0.88
g/l
0.10
62
87
296
1111
3.44
62.16
7.2
7.7
7.42
7.42
ph
0.28
185
637
296
1114
3.43
61.85
7.3
7.7
5.38
4.98
kpa
5.81
283
1078
206
614
4.03
61.07
8.4
3.5
5.52
5.06
kpa
7.13
197
584
202
596
4.05
60.71
3.9
2.9
10.48
11.09
g/l
0.97
193
543
294
1115
3.40
60.51
7.4
7.6
9.48
12.12
kpa
26.01
282
1080
291
1105
3.38
59.66
7.4
7.7
2.20
0.74
mmol/l
6.48
249
906
510
2706
2.96
57.54
8.1
4.3
—
—
—
0
0
198
604
3.90
56.49
8.1
3.5
7.42
7.42
ph
0.13
174
499
188
565
3.92
54.68
6.9
9.6
25.39
24.12
mmol/l
5.29
179
555
167
472
4.10
52.84
2.2
2.0
1.07
1.48
g/l
2.00
157
427
40
21
19.86
51.24
1.6
1.5
—
—
—
0
0
602
3636
2.87
50.84
13.0
6.0
8.81
9.18
%
2.51
587
3372
600
3619
2.86
50.78
12.3
5.8
62.99
58.40
%
16.90
584
3420
601
3641
2.85
50.20
12.8
5.9
2.51
2.87
%
3.31
584
3370
494
2718
2.75
49.74
11.3
5.6
—
—
—
0
0
599
3642
2.82
49.34
13.1
6.0
0.58
0.65
%
2.55
583
3372
295
1249
3.00
48.91
2.5
2.1
—
—
—
0
0
600
3683
2.78
47.94
12.9
6.0
22.00
26.02
%
17.41
588
3453
624
3908
2.82
47.91
12.1
5.7
0.72
0.61
e9/l
18.78
569
3281
625
3920
2.82
47.80
12.1
5.7
0.04
0.04
e9/l
3.47
571
3295
634
4021
2.82
47.16
12.6
5.8
0.20
0.20
e9/l
0.30
578
3442
628
3974
2.79
46.73
12.2
5.8
1.78
1.94
e9/l
1.24
579
3431
149
427
3.97
45.94
8.7
3.6
—
—
—
0
0
251
1016
3.02
44.60
7.3
8.0
93.04
95.72
%
8.60
243
989
171
554
3.56
43.92
2.3
1.5
—
—
—
0
0
115
293
4.34
41.43
1.4
1.2
—
—
—
0
0
81
159
5.49
39.83
1.6
1.1
—
—
—
0
0
42
39
11.23
39.32
1.5
2.4
686.54
535.94
e6/l
0.78
35
31
41
38
11.24
38.43
1.6
2.6
268.91
259.88
e6/l
0.06
34
33
647
4400
2.55
37.48
14.5
9.3
5.54
4.18
e9/l
22.60
593
3789
47
56
8.79
36.75
1.6
2.2
1623.10
1113.53
e6/l
2.37
40
49
109
340
3.50
29.20
9.2
3.8
25.95
24.87
mmol/l
2.65
101
310
181
775
2.66
27.71
1.6
1.5
—
—
—
0
0
206
941
2.53
27.59
2.3
1.8
—
—
—
0
0
482
3161
2.09
26.48
4.7
3.3
1867.08
1764.41
ng/l
0.19
446
2769
276
1473
2.24
25.73
4.3
3.1
0.81
0.82
mmol/l
0.28
259
1387
292
1627
2.16
24.22
2.1
1.7
1.55
1.56
mg/l
0.00
247
1285
184
868
2.40
22.60
7.1
7.3
1.51
1.41
mmol/l
0.48
177
854
200
988
2.31
22.05
4.3
3.5
6.35
5.72
kpa
8.65
193
961
199
986
2.30
21.76
4.3
3.6
7.38
7.38
ph
0.70
126
571
191
943
2.29
21.00
4.4
3.5
3.47
1.74
mmol/l
6.48
179
799
592
4388
1.96
20.92
9.3
6.8
9.88
12.64
umol/l
10.61
576
4194
242
1333
2.10
20.14
2.1
1.5
2.86
2.69
g/l
0.68
179
749
171
822
2.32
19.94
8.2
8.5
—
—
—
0
0
47
106
4.62
19.59
2.1
1.5
—
—
—
0
0
47
106
4.62
19.59
2.1
1.5
—
—
—
0
0
47
106
4.62
19.59
2.1
1.5
—
—
—
0
0
47
106
4.62
19.59
2.1
1.5
—
—
—
0
0
181
910
2.23
18.89
1.3
1.3
446.36
473.64
titre
0.12
44
220
62
185
3.52
17.67
8.8
4.1
—
—
—
0
0
172
869
2.20
17.65
2.5
2.2
0.19
0.20
g/l
0.30
162
803
33
60
5.67
17.53
1.4
1.2
—
—
—
0
0
108
446
2.61
17.41
2.7
1.8
0.98
2.47
ug/l
1.05
97
388
529
3951
1.79
16.39
5.7
5.3
32.28
34.74
g/l
16.87
501
3676
144
710
2.22
15.58
6.0
4.1
1.76
0.66
%
0.83
55
230
581
4497
1.78
15.56
10.3
7.6
1.20
1.21
mmol/l
1.38
503
3829
366
2496
1.77
15.16
2.9
2.3
3.35
2.91
mg/l
2.09
316
2128
147
748
2.15
14.66
6.0
4.3
1.23
0.87
%
0.47
56
252
141
708
2.17
14.54
6.1
4.4
0.06
0.11
%
0.48
49
213
157
823
2.09
14.48
3.8
3.1
280.54
241.40
ng/l
0.29
145
761
532
4077
1.71
14.15
9.7
6.8
1.20
1.21
mmol/l
1.29
494
3724
562
4382
1.72
13.93
21.4
20.0
1.32
1.36
inr
0.82
490
3709
54
174
3.23
13.65
10.4
4.6
3.03
2.79
mmol/l
0.25
46
114
271
1740
1.79
13.49
7.5
4.3
137.33
336.99
ng/l
2.31
237
1514
277
1792
1.78
13.43
3.7
3.2
492.43
545.25
mosm/kgh2o
4.80
251
1579
157
848
2.02
13.29
7.3
7.1
11.05
11.62
mmol/l
0.43
149
817
125
627
2.15
12.86
9.2
9.5
91.98
94.27
%
3.96
125
627
253
1622
1.77
12.52
2.7
2.7
9.86
12.21
umol/l
6.17
228
1501
68
264
2.70
12.36
7.8
7.2
1.29
1.40
mmol/l
0.46
58
233
227
1419
1.79
12.21
2.8
2.7
18.91
22.23
%
2.86
209
1312
27
57
4.85
12.19
1.7
2.7
15.89
15.85
%
0.01
27
57
59
214
2.88
12.18
3.2
2.1
132.76
126.86
g/l
1.04
38
169
368
2634
1.66
12.05
3.4
2.6
51.46
93.89
u/l
0.78
339
2433
41
122
3.47
11.76
3.8
2.8
5.93
4.62
e9/l
1.62
41
122
135
722
2.02
11.67
2.8
2.2
297.39
387.55
nmol/l
5.30
128
668
237
1525
1.74
11.45
7.6
4.8
—
—
—
0
0
133
721
1.99
11.05
6.7
4.6
0.10
0.17
%
0.34
42
198
54
200
2.81
10.74
2.5
2.0
13.18
13.20
mg/l
0.01
49
181
232
1522
1.70
10.31
2.7
2.7
2.13
2.23
g/l
1.74
212
1396
60
241
2.59
10.21
5.0
3.6
2.16
1.55
index
0.49
31
131
297
2082
1.63
10.19
6.6
4.3
85.19
83.50
%
0.50
288
2048
147
846
1.88
10.19
3.9
2.9
4.62
4.35
kpa
0.75
139
825
450
3486
1.56
10.05
7.3
4.4
41.42
56.35
ng/l
0.81
365
2821
437
3363
1.57
10.05
20.8
12.3
0.00
0.00
e9/l
1.29
363
2733
150
877
1.85
9.88
2.2
2.9
64.43
66.17
g/l
1.76
132
797
197
1253
1.73
9.75
6.7
5.8
1.11
1.04
mmol/l
2.37
179
1151
345
2531
1.58
9.68
5.0
3.5
0.61
0.47
e6/l
0.40
279
1924
41
139
3.04
9.57
2.8
1.8
1.52
1.67
mmol/l
0.62
41
133
363
2708
1.56
9.40
5.5
4.3
7.40
7.40
ph
0.27
280
1963
18
19
9.64
9.29
1.8
1.4
—
—
—
0
0
630
5328
1.57
9.07
7.1
5.3
284.00
2181.80
e6/l
—
8
97
43
155
2.86
9.02
4.1
2.9
62.78
59.61
%
0.78
43
155
336
2483
1.55
8.98
4.2
3.2
31.79
35.73
u/l
0.72
317
2342
370
2797
1.54
8.90
4.0
3.5
—
—
—
0
0
126
725
1.85
8.69
2.1
2.7
—
—
—
0
0
57
243
2.43
8.59
1.5
1.7
—
—
—
0
0
18
23
7.96
8.39
1.3
3.1
9.62
14.39
%
0.34
13
18
23
59
3.97
8.19
3.3
2.8
—
—
—
0
0
76
378
2.10
7.96
2.1
3.8
121.19
68.42
mg/l
0.36
54
327
71
345
2.15
7.90
1.9
3.6
10.84
3.61
ratio
0.41
35
204
31
100
3.17
7.89
4.4
5.0
—
—
—
0
0
31
101
3.14
7.76
2.9
2.0
88.61
89.78
%
0.61
31
101
25
71
3.59
7.73
1.2
1.2
7.33
7.41
ph
0.53
16
51
377
2929
1.48
7.64
5.1
3.7
99.18
91.00
e6/l
0.07
310
2307
432
3450
1.47
7.60
3.8
3.1
124.42
155.29
ug/l
2.70
395
3140
688
6030
1.55
7.60
14.3
8.5
85.54
82.55
u/l
0.70
668
5671
75
378
2.07
7.59
2.1
3.8
35.14
85.97
mg/l
0.95
53
329
24
68
3.60
7.46
1.3
1.8
—
—
—
0
0
587
4992
1.48
7.38
9.3
5.3
6.77
6.87
mmol/l
0.56
568
4790
150
952
1.69
7.35
5.1
3.0
6.89
5.28
e9/l
0.56
125
796
295
2197
1.50
7.29
3.7
3.1
373.70
360.57
umol/l
1.00
253
1881
20
51
3.99
7.19
1.1
1.0
0.22
1.47
u/ml
—
6
24
312
2358
1.49
7.15
9.7
6.4
—
—
—
0
0
210
1461
1.57
7.08
4.5
3.4
2.00
1.71
e6/l
0.34
102
762
20
52
3.91
7.01
1.1
1.0
0.44
5.09
u/ml
—
8
27
402
3201
1.45
7.00
6.0
4.3
76.23
120.75
e6/l
0.74
319
2372
167
1103
1.63
7.00
1.4
1.3
—
—
—
0
0
55
254
2.24
6.95
1.5
1.5
294.50
260.54
ug/g
0.59
34
156
17
40
4.31
6.77
3.3
2.1
665.24
1744.35
u/ml
0.97
17
40
22
63
3.55
6.74
1.2
1.1
0.24
1.31
u/ml
1.51
12
33
206
1445
1.55
6.66
2.7
2.0
30.05
29.74
s
0.21
198
1408
281
2105
1.48
6.64
3.7
2.8
4.91
4.52
e6/l
0.28
265
1931
145
937
1.65
6.61
2.3
2.8
8.92
9.45
umol/l
0.10
123
847
425
3445
1.43
6.60
2.9
2.4
78.64
79.70
nmol/l
0.30
376
3006
83
461
1.88
6.39
4.6
3.3
27.41
24.87
mmol/l
4.42
83
443
122
760
1.70
6.38
2.3
2.4
27.74
36.43
u/l
3.12
108
625
18
47
3.89
6.28
1.2
1.0
0.22
0.31
u/ml
—
7
26
43
187
2.36
6.26
1.4
1.3
60.38
61.22
mmol/l
0.04
34
153
34
133
2.62
6.18
1.3
1.3
46726.93
126197.25
e6/l
0.69
14
72
172
1177
1.57
6.17
1.4
1.3
59.05
34.97
iu/ml
0.55
61
365
163
1111
1.57
5.94
1.4
1.3
32.26
13.56
u/ml
0.82
46
385
17
35
4.93
5.76
3.5
1.7
51.81
51.05
ug/l
0.02
17
35
133
871
1.62
5.73
3.3
2.6
5.72
6.86
ug/l
0.51
107
761
36
151
2.44
5.69
1.3
1.4
1619.42
1395.29
e6/l
0.15
24
101
33
133
2.54
5.67
1.3
1.4
—
—
—
0
0
180
1267
1.52
5.66
2.2
2.6
1.77
1.78
%
0.04
148
1141
69
377
1.90
5.60
1.2
1.3
—
—
—
0
0
132
869
1.61
5.56
5.5
4.5
7.38
7.36
ph
1.48
100
616
16
33
4.91
5.44
1.2
1.1
1.20
1.21
u/ml
—
8
13
16
34
4.77
5.31
1.2
1.0
1.28
2.43
u/ml
—
8
14
157
2175
0.67
5.11
3.6
3.6
—
—
—
0
0
15
32
4.75
5.00
1.1
1.1
0.20
0.07
u/ml
—
6
10
13
24
5.48
4.92
2.2
1.2
—
—
—
0
0
27
106
2.59
4.92
2.0
2.3
10.09
11.00
mmol/l
0.62
27
106
336
2718
1.37
4.87
2.9
2.3
232.77
228.23
u/l
0.02
309
2574
31
131
2.41
4.86
1.5
1.6
—
—
—
0
0
10
13
7.76
4.85
1.0
1.0
—
—
—
0
0
647
7059
0.72
4.66
5.9
6.4
2.31
2.50
mmol/l
7.06
577
6383
210
1580
1.43
4.64
4.5
3.2
0.87
1.04
e6/l
0.57
105
881
23
86
2.72
4.61
1.2
1.1
—
23.78
—
0
13
143
1001
1.51
4.58
2.1
2.7
70.77
65.93
e9/l
0.92
101
769
630
6895
0.73
4.56
5.2
5.5
4.20
4.38
mmol/l
4.04
563
6268
42
208
2.07
4.54
2.2
3.5
478.42
1848.28
u/ml
0.56
36
195
624
6831
0.74
4.44
5.2
5.4
1.45
1.43
mmol/l
0.23
554
6148
66
385
1.77
4.39
1.8
2.7
10.31
10.82
g/l
0.39
58
337
156
2110
0.69
4.39
3.2
3.6
0.61
0.82
ug/l
3.74
111
1507
28
120
2.37
4.28
1.3
1.4
—
—
—
0
0
13
29
4.53
4.25
1.9
1.1
—
—
—
0
0
114
775
1.54
4.18
2.0
2.1
449.14
155.35
ug/g
0.79
90
609
145
1037
1.47
4.17
3.1
4.4
4.60
25.87
ug/l
1.91
131
874
40
202
2.02
4.13
8.0
8.0
10.66
11.31
mmol/l
0.49
35
183
40
202
2.02
4.13
8.0
8.0
102.34
105.60
mmol/l
2.15
35
183
19
70
2.75
3.94
1.3
1.2
—
—
—
0
0
262
2096
1.35
3.93
2.9
2.5
—
—
—
0
0
7
243
0.28
3.91
1.0
1.5
—
—
—
0
0
503
4447
1.29
3.53
5.3
3.3
63.97
56.49
u/l
0.63
460
4081
8
13
6.20
3.50
1.4
1.2
—
—
—
0
0
650
6999
0.76
3.44
5.8
5.8
6.01
6.11
mmol/l
1.08
584
6253
22
94
2.37
3.43
1.8
1.7
12.07
10.21
%
0.75
22
94
382
3274
1.28
3.38
4.4
3.8
6.24
6.26
ph
0.13
199
1822
9
18
5.04
3.37
8.8
15.6
1055.33
939.83
nmol/l
—
9
18
8
14
5.75
3.34
1.0
1.2
25.88
27.43
s
—
8
14
101
704
1.49
3.32
3.4
4.1
90.76
97.29
ng/l
0.34
85
604
6
7
8.62
3.26
1.0
1.0
—
—
—
0
0
6
7
8.62
3.26
1.0
1.0
—
—
—
0
0
6
7
8.62
3.26
1.0
1.0
—
—
—
0
0
325
2742
1.29
3.22
3.1
2.6
—
—
—
0
0
242
2916
0.77
3.05
1.9
2.0
1.33
1.26
mmol/l
0.52
187
2372
45
267
1.72
2.90
3.9
3.5
0.80
0.81
nmol/l
0.04
37
215
15
59
2.57
2.79
1.1
1.0
—
—
—
0
0
21
97
2.19
2.78
1.1
1.3
269.46
273.73
mosm/kgh2o
0.31
13
71
643
6872
0.79
2.71
7.5
7.4
41.63
40.46
mmol/mol
2.50
587
6307
59
383
1.58
2.71
2.2
2.2
0.00
0.01
estimate
0.50
18
101
15
60
2.52
2.71
1.1
1.0
—
—
—
0
0
15
60
2.52
2.71
2.3
2.1
—
—
—
0
0
349
3022
1.25
2.68
3.5
3.6
2.34
2.35
mmol/l
0.28
313
2710
8
19
4.24
2.68
2.3
2.0
—
—
—
0
0
74
509
1.49
2.63
1.5
1.9
1.80
1.53
g/l
1.77
66
451
87
620
1.44
2.59
1.7
1.5
—
—
—
0
0
450
4018
1.23
2.58
2.5
2.3
91.22
94.65
pmol/l
0.88
272
2106
16
68
2.38
2.56
1.6
2.6
7.65
8.26
mmol/l
0.27
16
68
16
68
2.38
2.56
1.3
1.2
—
—
—
0
0
454
4068
1.23
2.48
4.9
4.3
0.00
0.00
estimate
-0.00
111
899
21
103
2.06
2.43
1.6
2.6
0.54
1.26
g/24h
1.48
12
60
24
124
1.96
2.42
1.2
1.1
—
—
—
0
0
99
732
1.39
2.41
5.4
3.8
1.21
1.22
mmol/l
1.83
91
620
462
4158
1.22
2.39
5.0
4.3
0.00
0.36
estimate
0.52
105
860
46
291
1.61
2.38
2.8
1.5
7.96
7.19
iu/ml
0.06
14
76
7
17
4.14
2.36
5.4
4.7
—
—
—
0
0
74
523
1.45
2.32
1.2
1.2
—
—
—
0
0
458
4134
1.21
2.25
4.9
4.3
0.00
5.51
estimate
1.08
113
924
226
1896
1.25
2.24
3.4
3.1
2.50
2.46
mmol/l
8.90
205
1697
61
418
1.49
2.24
1.6
1.3
—
—
—
0
0
18
86
2.11
2.24
1.2
1.2
2.90
6.89
u/ml
—
10
38
616
6566
0.82
2.22
4.4
4.6
1.25
1.25
mmol/l
0.06
542
5847
33
195
1.72
2.22
3.2
2.7
34.04
32.20
umol/l
0.16
28
173
93
696
1.37
2.13
1.8
1.5
—
—
—
0
0
85
630
1.38
2.07
5.4
4.4
—
—
—
0
0
66
472
1.43
1.98
2.5
2.5
—
—
—
0
0
218
1847
1.24
1.97
2.1
1.8
1146.20
1183.16
nmol/l
0.18
167
1394
7
21
3.35
1.96
1.7
1.5
27.86
31.86
%
—
7
21
5
11
4.56
1.94
2.0
5.5
15.12
14.82
ml/dl
—
5
11
178
1478
1.25
1.93
1.3
1.3
0.91
1.40
u/ml
1.39
37
376
25
144
1.76
1.86
1.5
1.3
—
—
—
0
0
12
53
2.28
1.81
2.3
3.3
28.40
34.84
%
—
5
33
48
330
1.48
1.78
1.8
3.1
1400.42
274.72
mg/l
0.54
24
126
27
162
1.69
1.76
1.5
2.4
0.79
0.82
%
0.16
20
124
516
5537
0.85
1.75
55.3
26.2
326.29
331.33
g/l
26.32
510
5502
22
126
1.76
1.69
1.5
1.4
152.80
170.84
au/ml
—
5
35
316
2816
1.19
1.67
1.9
1.8
18.66
20.34
nmol/l
1.25
265
2356
15
76
1.99
1.65
1.1
1.4
—
—
—
0
0
324
3599
0.85
1.64
5.4
6.3
2.45
4.77
ug/l
1.12
275
3173
16
84
1.92
1.60
1.3
1.3
0.20
0.19
nmol/l
0.14
11
66
6
20
3.01
1.58
1.2
1.3
—
—
—
0
0
333
3000
1.17
1.52
2.5
2.4
—
—
—
0
0
9
38
2.38
1.46
2.7
1.5
—
—
—
0
0
7
28
2.51
1.45
1.1
2.2
0.62
0.60
mmol/l
—
7
28
5
16
3.14
1.44
1.2
1.4
6.11
7.74
mmol/l
—
5
16
12
59
2.05
1.44
1.0
1.2
—
—
—
0
0
35
239
1.48
1.39
1.6
1.6
47.07
20.97
u/ml
—
6
43
20
119
1.70
1.38
1.3
1.3
—
—
—
0
0
733
7588
0.84
1.38
63.3
29.8
129.54
132.02
g/l
4.22
724
7475
733
7587
0.84
1.37
62.5
29.4
29.99
30.50
pg
9.25
724
7474
733
7587
0.84
1.37
62.7
29.5
4.37
4.37
e12/l
0.02
718
7376
733
7587
0.84
1.37
63.8
30.1
39.48
39.42
%
0.12
724
7471
733
7586
0.84
1.36
62.7
29.6
268.01
235.35
e9/l
23.16
719
7408
733
7586
0.84
1.36
62.5
29.5
91.82
91.89
fl
0.14
724
7474
219
1929
1.18
1.30
4.6
4.1
—
0.18
—
0
28
734
7588
0.84
1.30
62.7
29.6
8.49
6.93
e9/l
41.92
718
7376
14
243
0.57
1.29
1.4
1.2
—
—
—
0
0
14
241
0.57
1.26
10.8
12.3
—
—
—
0
0
9
45
2.01
1.23
2.6
1.3
—
—
—
0
0
27
180
1.51
1.22
1.3
1.2
13.04
2.74
u/ml
—
7
20
20
124
1.63
1.21
1.1
1.2
403.60
314.37
u/ml
—
10
64
159
1829
0.84
1.19
5.3
4.7
1.02
1.02
kg/l
0.49
117
1244
27
182
1.50
1.17
1.3
1.2
11.09
2.61
u/ml
—
7
30
0
34
0.00
1.16
0.0
1.3
—
108.52
—
0
24
24
158
1.53
1.15
1.2
1.2
—
—
—
0
0
5
20
2.51
1.15
1.0
1.1
—
—
—
0
0
14
80
1.76
1.13
1.2
1.1
—
—
—
0
0
5
22
2.28
1.03
3.0
1.6
—
—
—
0
0
17
106
1.62
1.03
1.2
2.3
—
—
—
0
0
7
34
2.07
1.03
2.7
1.7
39.43
39.99
g/l
—
7
34
7
35
2.01
1.00
1.0
1.0
—
—
—
0
0
7
35
2.01
1.00
1.1
1.0
—
—
—
0
0
721
7424
0.87
0.98
20.8
13.1
23.56
24.98
u/l
0.85
707
7151
5
23
2.18
0.98
1.6
1.6
—
—
—
0
0
734
7548
0.87
0.98
53.3
26.5
86.54
86.07
umol/l
0.08
723
7440
402
3763
1.12
0.96
3.2
3.0
—
—
estimate
—
0
0
16
101
1.59
0.94
1.2
1.2
—
—
—
0
0
173
1934
0.87
0.90
1.3
1.3
—
—
—
0
0
19
127
1.51
0.89
1.6
1.1
—
—
—
0
0
641
6629
0.89
0.85
5.8
5.3
1.91
2.06
mu/l
1.50
592
5958
14
88
1.60
0.84
1.4
1.2
—
—
—
0
0
44
346
1.29
0.83
3.3
3.1
4.13
4.28
pmol/l
0.50
35
297
8
46
1.75
0.82
1.1
1.7
—
—
—
0
0
6
32
1.88
0.82
1.7
1.4
—
—
—
0
0
8
47
1.71
0.80
1.4
1.6
73.38
87.21
umol/l
—
8
47
10
58
1.73
0.80
1.5
1.2
—
—
—
0
0
31
235
1.33
0.76
1.4
1.6
0.45
0.33
mg/l
—
10
102
6
34
1.77
0.76
1.5
1.1
—
—
—
0
0
0
28
0.00
0.76
0.0
1.3
—
138.71
—
0
21
9
54
1.67
0.74
2.6
1.4
—
—
—
0
0
9
55
1.64
0.73
2.6
1.4
—
—
—
0
0
14
207
0.67
0.73
1.3
1.2
—
—
—
0
0
9
56
1.61
0.72
2.6
1.4
—
—
—
0
0
7
40
1.76
0.71
1.0
1.0
—
—
—
0
0
9
57
1.58
0.71
2.6
1.4
—
—
—
0
0
9
57
1.58
0.71
2.6
1.4
—
—
—
0
0
16
109
1.48
0.71
2.6
2.6
—
—
—
0
0
9
143
0.63
0.70
1.3
1.7
—
—
—
0
0
84
725
1.17
0.69
1.4
1.4
—
—
—
0
0
15
102
1.48
0.67
1.3
1.3
—
0.68
—
0
6
731
7472
0.90
0.66
51.1
24.4
4.02
4.02
mmol/l
0.00
719
7312
5
29
1.73
0.64
1.0
1.3
98.00
160.61
mmol/24h
—
5
29
730
7135
1.11
0.63
52.5
19.2
30.24
28.32
mg/l
1.08
703
6055
731
7463
0.90
0.61
50.8
24.1
138.86
139.61
mmol/l
10.08
719
7312
104
924
1.14
0.60
1.3
1.3
—
—
—
0
0
19
254
0.74
0.59
8.3
4.8
—
—
—
0
0
0
23
0.00
0.58
0.0
3.7
—
6.21
—
0
23
15
106
1.42
0.58
1.0
1.0
—
—
—
0
0
12
81
1.49
0.57
1.4
1.1
—
—
—
0
0
12
82
1.47
0.54
1.8
2.7
548.83
756.42
mg
0.31
12
82
28
222
1.27
0.54
1.6
1.3
—
—
—
0
0
330
3134
1.08
0.54
6.4
4.1
—
0.73
—
0
15
55
640
0.85
0.53
2.8
2.4
14.68
12.11
nmol/l
1.10
43
558
12
83
1.45
0.52
1.4
1.6
17.83
40.01
ng/l
0.88
12
83
52
444
1.18
0.52
2.9
2.9
—
—
—
0
0
254
2391
1.09
0.52
5.2
4.4
0.00
0.00
estimate
0.50
99
805
225
2107
1.09
0.52
4.7
3.9
0.11
0.07
estimate
0.15
90
697
9
136
0.66
0.51
1.1
1.1
—
—
—
0
0
523
5396
0.93
0.51
6.3
4.8
—
5942.47
—
0
17
12
84
1.43
0.49
1.3
1.3
—
—
—
0
0
34
280
1.22
0.49
1.3
1.2
—
—
—
0
0
51
440
1.17
0.46
2.7
2.7
14.82
20.93
au/ml
—
5
27
706
7191
0.92
0.46
35.8
17.8
—
—
—
0
0
19
147
1.30
0.45
1.8
1.6
58.65
50.97
iu/l
—
7
50
7
51
1.38
0.44
1.6
1.2
—
—
—
0
0
5
32
1.57
0.42
3.6
1.3
—
—
—
0
0
14
105
1.34
0.41
1.0
1.1
—
—
—
0
0
5
35
1.43
0.39
1.8
1.3
—
—
—
0
0
10
136
0.73
0.38
1.1
1.8
—
—
—
0
0
5
80
0.62
0.35
1.2
1.2
345.40
352.33
nmol/l
—
5
66
6
87
0.69
0.33
1.3
1.1
1.34
1.49
nmol/l
—
6
78
38
433
0.87
0.32
2.1
2.1
—
—
—
0
0
7
54
1.30
0.30
1.6
1.2
—
—
—
0
0
61
669
0.91
0.29
1.5
1.5
—
—
—
0
0
51
461
1.11
0.27
1.3
1.3
—
—
—
0
0
18
151
1.20
0.25
1.1
1.1
—
—
—
0
0
21
179
1.18
0.25
1.1
1.6
—
—
—
0
0
85
793
1.08
0.25
2.2
2.2
0.00
0.02
estimate
0.50
19
150
6
85
0.70
0.24
1.0
1.1
—
—
—
0
0
17
196
0.86
0.18
1.2
1.1
—
—
—
0
0
12
100
1.20
0.18
1.6
2.3
—
—
—
0
0
7
63
1.11
0.17
2.0
1.1
151.14
98.46
pmol/l
—
7
63
5
66
0.76
0.17
1.2
1.9
74.64
111.03
ng/l
—
5
66
8
69
1.16
0.16
1.6
1.4
—
—
—
0
0
299
3048
0.97
0.14
4.3
4.2
11.51
8.17
mg/mmol
0.48
184
1937
554
5483
1.03
0.13
4.4
4.1
15.12
15.08
pmol/l
0.10
504
4894
38
355
1.07
0.12
1.3
1.3
—
—
—
0
0
109
1126
0.96
0.11
1.4
1.4
—
—
—
0
0
13
147
0.88
0.11
1.0
1.4
—
—
—
0
0
193
1965
0.98
0.09
1.9
1.8
41176954.29
22927573.96
pmol/l
0.17
153
1592
6
57
1.05
0.08
2.3
2.5
—
—
—
0
0
297
3007
0.98
0.08
3.5
3.4
6.48
7.19
mmol/l
1.92
241
2480
7
66
1.06
0.08
2.1
2.3
1.36
2.01
ug/l
—
7
54
61
630
0.97
0.07
3.3
3.1
6.17
6.07
ph
0.37
40
448
9
102
0.88
0.06
1.0
1.0
—
—
—
0
0
18
190
0.95
0.04
1.1
1.1
—
—
—
0
0
23
220
1.05
0.03
1.6
1.6
16867.29
14740.17
e6/l
0.13
17
151
569
5673
1.01
0.03
49.8
24.2
14.66
13.92
%
21.68
563
5592
306
3067
1.00
0.00
5.3
4.4
0.27
0.04
estimate
0.39
92
749
33
331
1.00
0.00
1.3
1.2
88.60
133.85
u/ml
0.47
12
117
22
217
1.01
0.00
2.1
2.5
248.87
85.42
ug/min
0.66
12
126
297
2971
1.00
0.00
3.5
3.5
60.92
46.26
mg/l
0.49
191
1931
0
5
0.00
0.00
0.0
5.6
—
0.43
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
1.89
—
0
8
5
50
1.00
-0.00
1.0
1.0
338.00
280.93
mg/l
—
5
44
5
49
1.02
-0.00
2.2
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint COPD_OPPORTUNIST_INFECTIONS and mortality.

Females

Parameter HR [95% CI] p-value
COPD_OPPORTUNIST_INFECTIONS 2.652 [2.3, 3.05] < 0.001
Birth year 1.0 [0.99, 1.01] 0.953

During the follow-up period (1.1.1998 — 31.12.2019), 633 out of 1389 females with COPD_OPPORTUNIST_INFECTIONS died.

Males

Parameter HR [95% CI] p-value
COPD_OPPORTUNIST_INFECTIONS 2.541 [2.21, 2.92] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1245 out of 2143 males with COPD_OPPORTUNIST_INFECTIONS died.

Mortality risk

Mortality risk for people of age

years, who have COPD_OPPORTUNIST_INFECTIONS.

N-year risk Females Males
1 0.272% 0.412%
5 1.622% 2.284%
10 4.163% 5.977%
15 8.101% 11.142%
20 14.53% 18.826%

Relationships between endpoints

Index endpoint: COPD_OPPORTUNIST_INFECTIONS – COPD related to chronic (opportunist) infections

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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