testicular carcinoma: A primary or metastatic malignant neoplasm that affects the testis. Representative examples include seminoma, embryonal carcinoma, sarcoma, leukemia, and lymphoma.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleonly males |
244368 |
2. Check conditionsNone |
244368 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
179 |
4. Check minimum number of eventsNone |
179 |
5. Include endpointsNone |
179 |
6. Filter based on genotype QC (FinnGen only) |
157 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D29
- Name in latin
- Neoplasma benignum testis
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Testis
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm of male genital organs
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1309 | - | 1309 |
| Only index persons | 1140 | - | 1140 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | - | 0.04 |
| Only index persons | 0.04 | - | 0.04 |
| Median age at first event (years) | |||
| Whole population | - | - | 39.28 |
| Only index persons | - | - | 36.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 157 | - | 157 |
| Unadjusted period prevalence (%) | 0.07 | - | 0.07 |
| Median age at first event (years) | 47.48 | - | 47.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 164
- Matched controls
- 1640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D29.2
ICD-10 Finland
Benign neoplasm: Testis
+∞
153.1
122
*
KFC00
NOMESCO Finland
Unilateral orchiectomy
71.5
89.3
50
10
D40.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Testis
87.7
41.6
45
7
KF8AE
NOMESCO Finland
Ultrasound examination of scrotum
10.7
28.2
34
39
22200
ICD-8 Finland
Benign neoplasm of male genital organs, Testis
+∞
27.9
26
*
2220A
ICD-9 Finland
Benign neoplasm of male genital organs, Testis
+∞
17.0
16
*
9061/3-C62.9
ICD-O-3
Seminoma, NOS, of testis, NOS
+∞
13.7
13
*
C62.11
ICD-10 Finland
Malignant tumor of the descending testicle, seminoma
+∞
12.7
12
*
KFA00
NOMESCO Finland
Exploration of testis
23.5
12.3
17
8
7501
FHL
Testicular exploration (includes removal of biopsy, detorsion or appendix test)
105.9
9.5
10
*
7511
FHL
Orchidectomy (unilateral), also includes funicularectomy
83.7
7.5
8
*
JN4BD
NOMESCO Finland
Extensive body CT
3.3
6.9
28
95
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
54
234
2.95
9.00
3.3
2.6
12.91
14.27
nmol/l
0.55
47
215
19
45
4.64
7.71
2.1
1.5
7.31
5.36
u/l
0.41
14
37
5
6
8.54
2.77
2.2
3.2
1.60
6.98
ug/l
—
5
6
10
30
3.48
2.65
1.2
1.6
1.96
4.68
mg/l
—
10
23
8
26
3.18
2.04
1.1
1.2
—
—
—
0
0
108
905
1.57
1.96
5.7
5.6
3.55
2.73
ug/l
0.19
95
812
20
108
1.97
1.92
1.6
1.9
—
—
—
0
0
21
121
1.84
1.68
2.0
1.9
—
—
—
0
0
69
538
1.49
1.68
2.0
2.1
91.58
90.82
pmol/l
0.04
33
299
73
578
1.47
1.64
2.9
3.1
—
—
estimate
—
0
0
24
148
1.73
1.55
4.3
3.3
—
—
—
0
0
5
15
3.40
1.53
1.0
1.3
—
—
—
0
0
16
88
1.91
1.47
11.6
10.7
24.68
24.42
mmol/l
0.09
16
88
17
96
1.86
1.45
4.4
2.6
61.00
58.61
ml/min/173m2
—
7
41
10
47
2.20
1.36
1.7
1.4
—
—
—
0
0
38
280
1.46
1.19
3.3
4.4
215.69
280.25
ng/l
0.13
31
230
5
20
2.55
1.16
2.0
1.3
105.04
192.84
pmol/l
—
5
20
7
30
2.39
1.14
1.1
1.4
—
—
—
0
0
7
30
2.39
1.14
1.1
1.4
—
—
—
0
0
48
374
1.40
1.11
1.5
1.8
18.74
19.36
nmol/l
0.12
39
309
9
45
2.06
1.07
1.1
1.4
—
—
—
0
0
10
53
1.94
1.03
1.0
1.2
1.51
1.46
g/l
—
10
53
111
995
1.36
1.03
9.2
9.4
74.01
79.88
u/l
1.01
106
947
10
54
1.91
0.99
1.0
1.2
0.90
0.91
g/l
—
10
54
50
401
1.36
0.97
3.9
3.3
0.72
0.36
e6/l
0.36
39
302
64
534
1.33
0.95
2.8
2.9
177.10
182.43
ug/l
0.06
57
501
32
245
1.38
0.82
1.9
2.0
30.86
29.44
s
0.63
32
240
0
25
0.00
0.79
0.0
1.1
—
—
—
0
0
62
529
1.28
0.76
3.4
3.2
0.67
0.85
ug/l
0.92
39
335
81
721
1.24
0.68
4.9
4.7
20.79
22.14
%
0.37
38
356
68
594
1.25
0.67
4.7
6.0
35.00
35.36
g/l
0.19
63
565
5
28
1.81
0.66
2.8
2.1
—
—
—
0
0
72
636
1.24
0.64
9.9
9.7
1.20
1.20
mmol/l
0.19
60
561
20
148
1.40
0.63
3.0
4.1
1.29
1.24
mmol/l
0.02
15
120
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
6
38
1.60
0.55
1.0
1.5
—
—
—
0
0
13
91
1.47
0.55
3.8
3.7
23.50
23.81
mmol/l
0.16
13
91
6
40
1.52
0.52
10.0
7.7
—
328.00
—
0
6
132
1258
1.25
0.50
19.3
18.6
31.70
27.14
mg/l
0.64
109
1068
9
127
0.69
0.45
2.2
2.3
6.90
10.60
ug/l
—
9
112
44
382
1.21
0.45
4.7
4.1
0.00
0.05
estimate
0.96
18
126
6
92
0.64
0.43
8.0
5.0
62.15
102.94
ng/l
—
6
83
41
470
0.83
0.43
4.0
4.6
5.88
10.77
mg/mmol
0.69
25
342
5
34
1.48
0.40
4.0
2.4
—
—
—
0
0
53
590
0.85
0.40
3.8
4.0
47.75
42.79
ng/l
0.09
40
447
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
5
35
1.44
0.39
1.4
1.4
—
—
—
0
0
33
282
1.21
0.39
1.7
1.7
1.58
1.49
mg/l
0.05
27
219
0
19
0.00
0.39
0.0
3.8
—
29.40
—
0
10
27
227
1.23
0.37
7.6
8.5
105.37
104.06
mmol/l
0.73
27
227
87
926
0.87
0.35
2.6
3.7
34.34
57.36
u/l
6.61
82
878
98
926
1.14
0.33
4.8
4.4
10.04
12.06
mm/h
0.91
92
863
7
55
1.28
0.30
1.0
1.0
—
—
—
0
0
7
56
1.26
0.30
2.1
2.9
—
—
—
0
0
19
158
1.23
0.29
3.2
4.1
5.67
5.66
kpa
0.03
19
153
34
301
1.16
0.28
6.2
4.0
1.02
1.02
kg/l
0.21
27
201
9
72
1.26
0.26
2.3
2.3
1.33
2.82
ug/l
—
9
63
5
37
1.36
0.24
2.4
1.5
—
—
—
0
0
5
37
1.36
0.24
1.2
1.8
—
—
—
0
0
23
201
1.17
0.22
1.8
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
34
309
1.13
0.20
3.2
2.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
26
232
1.14
0.20
1.8
1.7
1332.83
1166.92
nmol/l
0.17
18
178
123
1199
1.10
0.18
6.2
7.0
39.97
40.25
mmol/mol
0.13
115
1128
12
141
0.84
0.17
7.2
8.9
—
—
—
0
0
118
1210
0.91
0.17
3.9
4.4
1.31
1.34
mmol/l
0.17
107
1113
13
149
0.86
0.14
6.8
8.7
11.38
10.12
mmol/l
0.20
13
144
78
751
1.07
0.14
11.9
11.4
4.11
4.38
e9/l
0.55
70
651
21
190
1.12
0.13
1.9
2.1
—
—
—
0
0
127
1247
1.08
0.12
4.8
5.3
4.47
4.37
mmol/l
0.55
117
1165
24
260
0.91
0.12
2.4
2.2
—
—
—
0
0
54
516
1.07
0.12
4.4
3.8
0.00
0.03
estimate
0.50
17
114
21
192
1.11
0.11
1.2
1.2
142.52
25.09
iu/ml
—
5
50
11
96
1.16
0.10
3.5
3.2
301.64
226.86
ng/l
0.18
11
85
88
857
1.06
0.10
3.2
3.2
15.15
14.85
pmol/l
0.53
81
763
5
45
1.11
0.10
1.2
1.8
—
—
—
0
0
27
253
1.08
0.09
4.0
2.9
0.45
1.07
e6/l
1.09
15
135
118
1197
0.95
0.07
5.0
5.3
6.07
6.12
mmol/l
0.18
111
1091
25
236
1.07
0.07
4.7
3.1
0.23
0.44
e6/l
0.76
13
120
9
100
0.89
0.06
4.6
3.5
1.10
1.73
mmol/l
—
9
72
19
178
1.08
0.06
1.4
1.5
—
—
—
0
0
126
1247
1.04
0.05
4.8
5.2
1.34
1.30
mmol/l
0.65
116
1153
67
657
1.03
0.04
4.5
3.8
0.00
0.00
estimate
-0.00
18
136
30
289
1.05
0.04
1.8
1.8
407.37
46988355.55
pmol/l
0.50
24
249
68
668
1.03
0.04
4.4
3.8
0.00
0.00
estimate
-0.00
18
138
77
758
1.03
0.03
3.0
3.0
—
—
—
0
0
10
92
1.09
0.03
1.9
2.0
—
—
—
0
0
39
380
1.03
0.03
4.0
3.3
0.00
0.00
estimate
-0.00
15
105
110
1092
1.02
0.01
4.3
4.1
1.82
2.04
mu/l
1.48
99
985
12
116
1.04
0.00
1.8
1.7
—
—
—
0
0
13
133
0.98
0.00
3.2
3.1
4.45
4.65
kpa
0.13
13
128
67
675
0.99
0.00
4.5
3.8
0.00
0.03
estimate
0.50
15
119
5
52
0.96
0.00
4.0
2.0
—
—
—
0
0
8
86
0.93
0.00
1.6
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
7.40
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
11
110
1.00
-0.00
1.2
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
127
1270
1.00
-0.00
5.5
5.9
2.64
2.61
mmol/l
0.15
118
1181
0
8
0.00
-0.00
0.0
1.0
—
10.88
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
152.35
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
51.78
—
0
6
8
88
0.90
-0.00
4.0
2.5
1.02
1.30
%
—
8
88
0
6
0.00
-0.00
0.0
3.3
—
41.17
—
0
6
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1295.67
—
0
6
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
40.42
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_TESTIS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_TESTIS | 1.218 [0.97, 1.53] | 0.089 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 128 out of 807 males with CD2_BENIGN_TESTIS died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_TESTIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.273% |
| 5 | No data | 1.509% |
| 10 | No data | 3.655% |
| 15 | No data | 6.935% |
| 20 | No data | 11.538% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_TESTIS – Benign neoplasm: Testis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data