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Tularaemia

Endpoint Browser PheWeb

AB1_TULARAEMIA

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A21
  • Hospital discharge: ICD-9 — 02[1]
  • Hospital discharge: ICD-8 — 02[1]
  • Cause of death: ICD-10 — A21
  • Cause of death: ICD-9 — 02[1]
  • Cause of death: ICD-8 — 02[1]

2 out of 7 registries used, show all original rules.

545

4. Check minimum number of events

None

545

5. Include endpoints

None

545

6. Filter based on genotype QC (FinnGen only)

490

Control definitions (FinnGen only)

Control exclude
AB1_ZOONOTIC_BACTERIAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4460 1976 2467
Only index persons 4103 1830 2273
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.07
Only index persons 0.08 0.07 0.09
Median age at first event (years)
Whole population 46.83 48.39 45.50
Only index persons 46.01 47.63 44.71

-FinnGen-

Key figures

All Female Male
Number of individuals 490 239 251
Unadjusted period prevalence (%) 0.10 0.08 0.12
Median age at first event (years) 51.29 48.91 53.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
502
Matched controls
5020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A21.9
ICD-10 Finland
Tularaemia, unspecified
+∞
284.3
245
*
A21.0
ICD-10 Finland
Ulceroglandular tularaemia
+∞
148.5
135
*
J01MA02
ATC
ciprofloxacin; systemic
6.1
85.3
345
1323
R50.9
ICD-10 Finland
Fever, unspecified
4.3
46.4
153
460
A21.2
ICD-10 Finland
Pulmonary tularaemia
+∞
32.7
31
*
A21.8
ICD-10 Finland
Other forms of tularaemia
+∞
24.2
23
*
A21
ICD-10 Finland
Tularaemia
+∞
18.9
18
*
A98.5
ICD-10 Finland
Haemorrhagic fever with renal syndrome
6.5
18.7
31
50
WX720
NOMESCO Finland
Own respiration
4.2
17.5
49
126
0210A
ICD-9 Finland
Tularaemia, Ulceroglandular tularaemia
+∞
16.8
16
*
J17.0*A21.2
ICD-10 Finland
Pneumonia (due to)(in) tularaemia
+∞
15.7
15
*
02100
ICD-8 Finland
Tularaemia, Glanduraris sive ulceroglandularis
+∞
13.6
13
*
0219X
ICD-9 Finland
Tularaemia, Unspecified tularaemia
+∞
13.6
13
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
12.2
132
707
WX704
NOMESCO Finland
Intubation
3.0
11.9
57
208
WVA20, ,
SPAT
4.1
11.2
31
79
SPAT1263
SPAT
Sampling
1.9
10.9
224
1496
UDC00
NOMESCO Finland
Ear microscopy
2.9
10.8
53
196
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
4.3
10.8
28
68
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.8
10.7
58
226
A21.7
ICD-10 Finland
Generalized tularaemia
+∞
10.4
10
*
0218X
ICD-9 Finland
Tularaemia, Other specified tularaemia
+∞
10.4
10
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
9.5
71
323
SPAT1324
SPAT
Screening procedure
2.3
9.4
80
386
SPAT1044
SPAT
Tympanometry
4.6
9.4
22
49
WZC00, ,
SPAT
2.1
8.5
86
444
XQ855, ,
SPAT
7.6
8.5
19
26
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.8
8.4
152
961
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
7.8
119
710
SPAT1255
SPAT
Intravenous administration of medicine
2.9
7.8
38
140
J01AA02
ATC
doxycycline; systemic
1.8
7.4
379
3168
02109
ICD-8 Finland
Tularaemia, Unspecified
+∞
7.3
7
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
7.1
88
488
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.5
7.0
17
39
WX725
NOMESCO Finland
Noninvasive ventilation
2.7
6.9
37
144
SPAT1310
SPAT
Counselling related to known health issue
1.7
6.6
158
1071
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
6.5
199
1434
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
2.6
6.4
37
149
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.7
6.3
34
132
XQ858, ,
SPAT
11.2
6.3
11
10
02107
ICD-8 Finland
Tularaemia, Suspecta
+∞
6.3
6
*
A21.1
ICD-10 Finland
Oculoglandular tularaemia
+∞
6.3
6
*
Z2221
NOMESCO Finland
Medical doctor
0.4
6.3
43
873
SPAT1301
SPAT
No procedures
1.7
6.1
153
1045
SPAT1193
SPAT
Pap smear
2.5
6.1
39
166

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
54
5
120.73
50.89
1.6
1.0
848.33
—
titre
—
24
0
204
1213
2.15
14.92
4.2
4.5
—
—
—
0
0
211
1292
2.09
14.10
4.0
3.2
0.00
0.07
estimate
0.58
62
389
26
49
5.54
13.38
1.2
1.1
—
—
—
0
0
220
1541
1.76
8.62
4.1
3.2
32.70
32.62
u/l
0.01
210
1463
204
1400
1.77
8.57
2.9
2.7
54.48
63.78
u/l
1.20
197
1305
138
865
1.82
7.73
5.4
3.9
159.22
316.12
ng/l
0.86
113
666
240
1760
1.70
7.71
4.3
3.6
0.02
0.02
estimate
0.03
65
410
277
2114
1.69
7.64
7.0
6.2
27.59
27.55
%
0.03
270
2022
273
2078
1.69
7.58
7.3
6.3
9.04
8.84
%
0.48
268
1965
272
2070
1.69
7.54
7.2
6.3
0.67
0.69
%
0.20
267
1947
154
1004
1.77
7.53
5.3
4.7
—
—
—
0
0
158
1040
1.76
7.47
3.9
3.8
1.02
1.02
kg/l
0.18
121
692
271
2077
1.66
7.18
7.1
6.2
2.66
2.89
%
1.03
264
1959
23
66
3.60
7.07
1.4
1.4
—
—
—
0
0
23
66
3.60
7.07
1.4
1.4
—
—
—
0
0
23
66
3.60
7.07
1.4
1.4
—
—
—
0
0
23
66
3.60
7.07
1.4
1.4
—
—
—
0
0
17
39
4.48
7.01
1.2
1.1
—
—
—
0
0
293
2341
1.60
6.18
4.3
3.7
0.00
0.00
estimate
-0.00
77
496
72
392
1.98
6.12
4.8
4.9
2.10
0.96
%
0.70
21
136
133
876
1.71
6.10
1.9
1.7
456.16
21390089.32
pmol/l
0.69
120
734
248
1911
1.59
6.05
6.4
5.0
35.98
35.85
g/l
0.13
238
1803
290
2321
1.59
5.99
7.0
6.3
0.18
0.19
e9/l
0.77
275
2026
176
1253
1.62
5.96
3.1
3.1
—
—
—
0
0
19
54
3.62
5.94
2.9
2.0
13.17
13.16
%
0.01
19
54
69
376
1.97
5.85
5.3
5.3
0.67
0.22
%
0.29
18
102
68
369
1.97
5.83
4.4
5.0
0.06
0.15
%
0.68
17
113
68
371
1.96
5.74
4.4
4.7
1.05
0.54
%
0.74
20
121
285
2292
1.56
5.61
6.8
6.1
1.85
1.93
e9/l
0.53
272
2026
313
2574
1.57
5.56
5.2
5.3
6.80
6.68
mmol/l
0.44
296
2435
280
2247
1.56
5.54
6.7
6.1
0.61
0.58
e9/l
1.37
265
1935
292
2366
1.56
5.52
4.3
3.7
0.00
0.67
estimate
0.51
73
456
280
2254
1.55
5.41
6.7
6.1
0.04
0.04
e9/l
0.65
266
1942
255
2027
1.52
5.11
11.5
12.7
1.22
1.23
inr
0.15
230
1665
25
93
2.78
5.08
3.3
4.2
21.12
25.72
mg/l
0.21
17
67
99
634
1.70
4.96
1.9
2.1
—
—
—
0
0
351
3000
1.57
4.96
4.2
4.1
—
0.14
—
0
7
97
621
1.70
4.86
1.3
1.3
396.52
523.94
titre
0.47
23
142
283
2317
1.51
4.82
4.3
3.7
0.00
0.00
estimate
-0.00
76
489
35
162
2.25
4.55
1.1
1.3
—
—
—
0
0
342
2943
1.51
4.36
5.9
4.4
—
2.71
—
0
5
67
1055
0.58
4.22
4.3
3.5
—
0.25
—
0
12
298
2509
1.46
4.13
10.2
9.6
4.22
4.08
e9/l
0.44
285
2188
47
257
1.91
3.97
5.6
6.1
—
—
—
0
0
27
126
2.21
3.48
4.9
3.8
1.97
2.73
ratio
0.33
18
67
257
2157
1.39
3.33
8.1
7.5
1.21
1.21
mmol/l
0.48
228
1886
104
742
1.51
3.26
1.2
1.3
7.21
10.76
u/ml
0.25
38
281
324
2834
1.40
3.24
5.5
4.5
861.47
230.94
e6/l
0.45
17
48
211
1723
1.39
3.18
3.5
3.1
—
—
—
0
0
28
138
2.09
3.17
5.5
4.1
30.29
97.76
mg/l
0.90
23
118
28
138
2.09
3.17
5.5
4.1
22.04
43.83
mg/l
0.90
23
119
22
98
2.30
3.17
1.3
1.3
—
—
—
0
0
81
555
1.55
3.05
2.8
3.1
7.32
4.68
e9/l
0.39
75
483
451
4223
1.67
3.05
19.5
15.9
28.38
23.81
mg/l
1.63
407
3476
22
100
2.25
3.04
1.1
1.3
306.08
283.12
u/ml
0.11
12
50
243
2048
1.36
2.94
3.0
2.8
—
—
estimate
—
0
0
76
519
1.55
2.91
5.6
9.5
7.43
7.42
ph
1.17
58
290
20
89
2.30
2.90
1.7
1.2
2.00
19.70
e6/l
0.93
14
64
6
9
6.73
2.87
2.7
2.0
2.50
2.89
%
—
6
9
47
738
0.60
2.86
3.5
2.9
0.80
2.27
e6/l
3.00
27
342
30
159
1.94
2.82
1.4
1.1
—
—
—
0
0
19
84
2.31
2.80
1.7
1.3
—
—
—
0
0
367
3319
1.39
2.74
9.8
8.3
75.86
78.69
u/l
0.58
360
3145
5
168
0.29
2.74
3.4
4.3
25.70
24.88
mmol/l
—
5
157
468
4458
1.74
2.52
14.3
12.0
28.27
26.97
u/l
0.81
461
4347
46
290
1.65
2.47
2.5
2.6
—
—
—
0
0
10
32
3.17
2.45
1.2
1.3
288140.00
87647.09
e6/l
—
10
23
73
515
1.49
2.41
5.6
9.5
2.20
0.76
mmol/l
2.93
57
435
269
2347
1.31
2.40
7.5
6.7
12.02
11.62
umol/l
0.18
258
2230
116
894
1.39
2.38
1.9
2.0
—
—
—
0
0
136
1682
0.74
2.38
1.9
2.1
—
—
—
0
0
219
1863
1.31
2.32
3.7
3.3
6.16
6.19
ph
0.14
150
1034
9
28
3.25
2.31
1.2
3.8
15.26
16.34
%
—
9
28
10
35
2.89
2.22
2.4
2.1
1651.40
1215.17
e6/l
—
10
30
14
293
0.46
2.21
5.5
10.6
23.52
24.27
mmol/l
0.82
14
288
200
1690
1.30
2.20
3.9
3.8
41.53
36.35
ng/l
0.17
124
1202
14
61
2.33
2.16
1.4
2.1
31.86
32.72
pg
0.28
14
61
105
809
1.38
2.15
1.3
1.3
25.06
30.93
iu/ml
0.28
39
257
419
3925
1.41
2.15
5.6
5.1
1.86
1.90
mu/l
0.26
405
3621
15
68
2.24
2.13
1.1
1.2
—
—
—
0
0
163
1346
1.31
2.11
2.7
2.2
178.08
259.40
u/l
0.62
153
1278
358
3283
1.32
2.05
4.5
4.1
14.65
14.78
pmol/l
0.45
339
2999
440
4166
1.45
2.05
5.1
4.9
1.42
1.43
mmol/l
0.21
426
3879
17
83
2.08
2.03
3.5
2.8
—
—
—
0
0
20
104
1.96
2.03
1.8
1.6
—
—
—
0
0
37
235
1.62
1.96
1.2
1.3
—
—
—
0
0
441
4184
1.44
1.96
5.3
5.1
4.64
4.60
mmol/l
0.37
426
3921
430
4072
1.39
1.83
5.0
5.0
5.94
5.97
mmol/l
0.16
413
3755
88
679
1.36
1.79
1.6
1.7
1260.86
1157.25
nmol/l
0.56
77
523
11
47
2.37
1.79
1.1
1.3
—
—
—
0
0
173
1471
1.27
1.74
7.3
6.0
—
—
—
0
0
25
403
0.60
1.72
5.6
9.2
—
—
—
0
0
181
1549
1.26
1.72
5.9
5.2
2.37
2.32
ug/l
0.04
175
1407
179
1530
1.26
1.72
3.5
3.3
7.94
7.85
mmol/l
0.10
165
1305
71
533
1.39
1.71
3.0
2.7
1.67
1.84
%
0.69
71
486
169
1436
1.27
1.70
4.2
4.1
3.04
9.76
mg/mmol
4.12
111
908
6
19
3.18
1.66
1.3
2.0
513.00
857.26
u/ml
—
6
19
16
83
1.96
1.66
3.8
2.6
31.77
9.37
pmol/l
0.46
16
83
444
4244
1.40
1.63
5.8
5.7
2.74
2.70
mmol/l
0.37
425
3964
64
477
1.39
1.62
1.5
1.6
—
—
—
0
0
8
32
2.52
1.60
1.0
1.3
—
—
—
0
0
165
1408
1.26
1.59
3.6
3.4
19.32
55.31
mg/l
4.27
113
920
117
1409
0.78
1.58
2.8
2.4
—
—
—
0
0
121
1001
1.28
1.50
1.7
1.7
1.09
1.34
mg/l
0.51
103
781
136
1143
1.26
1.48
2.6
2.1
2.44
2.85
mg/l
1.37
129
988
10
45
2.25
1.47
1.6
1.2
—
—
—
0
0
452
4347
1.40
1.46
19.8
13.9
—
—
—
0
0
9
38
2.39
1.46
2.3
1.1
—
—
—
0
0
6
23
2.63
1.37
1.2
1.5
55.17
62.50
ug/l
—
6
23
11
208
0.52
1.36
3.1
3.9
—
—
—
0
0
87
700
1.29
1.34
2.5
2.4
2.42
2.31
g/l
1.24
78
652
7
150
0.46
1.33
3.0
1.9
79.00
338.27
ug/l
—
7
143
29
423
0.67
1.32
3.7
8.2
1.21
1.34
mmol/l
0.62
29
416
153
1320
1.23
1.31
4.9
4.0
7.40
7.40
ph
0.32
136
926
8
34
2.37
1.29
1.3
3.4
7.61
7.97
mmol/l
—
8
34
5
18
2.79
1.29
1.0
1.2
5.26
6.92
mmol/l
—
5
18
5
18
2.79
1.29
1.0
1.4
—
—
—
0
0
24
156
1.57
1.22
4.9
2.1
4553.53
5025.30
u/l
0.03
12
62
124
1054
1.23
1.22
1.3
1.3
0.93
1.60
u/ml
0.83
42
294
228
2063
1.19
1.17
3.6
3.0
139.37
124.40
ug/l
0.38
215
1926
5
20
2.51
1.15
1.0
1.5
105.20
145.80
nmol/l
—
5
20
38
277
1.40
1.13
1.4
1.3
—
49.81
—
0
24
41
303
1.38
1.13
2.5
2.5
—
16.25
—
0
28
8
40
2.02
1.12
1.0
1.1
—
—
—
0
0
30
210
1.46
1.11
2.5
2.4
—
—
—
0
0
7
34
2.07
1.03
1.4
1.3
—
—
—
0
0
57
451
1.30
1.02
2.2
2.3
13.31
13.46
nmol/l
0.05
52
412
413
3968
1.23
1.00
4.4
4.2
1.28
1.30
mmol/l
0.15
397
3671
46
588
0.76
0.99
1.4
1.2
—
—
—
0
0
144
1268
1.19
0.98
1.8
1.7
20.16
20.37
nmol/l
0.06
131
1069
44
565
0.76
0.98
1.2
1.3
—
—
—
0
0
414
3983
1.22
0.96
6.5
6.3
40.09
39.41
mmol/mol
0.84
402
3761
45
348
1.32
0.96
5.2
3.6
—
—
—
0
0
6
28
2.16
0.91
3.3
2.1
728.33
616.86
e6/l
—
6
22
16
241
0.65
0.90
2.4
2.3
0.55
0.61
%
0.57
16
241
52
415
1.28
0.89
2.1
2.7
71.75
70.78
e9/l
0.05
46
308
29
213
1.38
0.86
1.7
2.1
0.00
0.00
estimate
-0.00
19
72
62
510
1.25
0.84
1.5
1.7
—
—
—
0
0
146
1306
1.17
0.82
3.3
3.2
1416.21
1251.03
ng/l
0.15
129
1107
6
33
1.83
0.79
2.0
2.3
648.50
548.56
ml
—
6
18
6
33
1.83
0.79
1.0
1.2
242.17
172.36
pmol/l
—
6
33
318
3015
1.15
0.78
3.8
3.4
44.74
51.05
u/l
0.80
301
2853
5
99
0.50
0.78
1.4
1.3
—
—
—
0
0
16
233
0.68
0.78
2.6
1.6
0.15
0.34
mg/l
—
7
109
126
1119
1.17
0.78
3.7
2.9
348.11
346.78
umol/l
0.05
118
988
6
34
1.77
0.76
1.2
2.1
41.83
37.92
%
—
6
34
10
59
1.71
0.76
2.3
3.1
—
—
—
0
0
112
1263
0.85
0.75
4.2
3.1
0.13
0.43
e6/l
3.64
98
895
11
67
1.66
0.75
2.5
2.6
—
—
—
0
0
16
109
1.48
0.71
2.9
2.0
2.52
3.56
iu/l
—
8
42
7
41
1.72
0.70
2.3
1.5
0.94
1.23
promille
—
7
30
7
42
1.68
0.68
3.7
1.3
27.17
30.37
ng/l
—
7
42
15
102
1.49
0.68
1.5
1.4
16695.67
16175.75
e6/l
0.02
15
72
106
939
1.16
0.68
1.5
1.4
2.43
2.46
g/l
0.08
83
590
7
43
1.64
0.67
2.1
2.0
—
—
—
0
0
143
1297
1.14
0.66
6.6
6.3
—
—
—
0
0
5
28
1.79
0.66
1.4
1.1
373.40
380.73
nmol/l
—
5
22
10
62
1.63
0.65
5.0
7.1
10.10
11.19
mg/l
—
10
57
63
537
1.20
0.64
3.0
3.0
8.71
8.20
umol/l
0.05
57
481
5
30
1.67
0.61
1.4
1.6
141.80
76.27
umol/l
—
5
30
23
174
1.34
0.61
1.1
1.1
0.87
0.91
g/l
0.28
23
174
13
186
0.69
0.60
1.5
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
219.36
—
0
20
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.7
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
8
53
1.52
0.58
1.1
1.2
—
—
—
0
0
53
451
1.20
0.56
3.9
3.4
7.39
7.38
ph
0.72
38
248
10
65
1.55
0.56
3.7
2.8
3.26
4.49
e9/l
—
10
65
14
193
0.72
0.54
2.1
2.0
—
—
—
0
0
6
39
1.54
0.53
1.0
1.2
104.17
99.82
pmol/l
—
6
39
13
92
1.42
0.51
1.2
1.1
—
—
—
0
0
30
365
0.81
0.49
1.5
1.4
—
—
—
0
0
12
165
0.72
0.47
2.2
2.1
—
—
—
0
0
5
85
0.58
0.45
1.2
1.1
—
—
—
0
0
5
85
0.58
0.45
1.2
1.1
—
—
—
0
0
138
1279
1.11
0.45
4.8
3.8
0.00
0.01
estimate
0.96
74
448
207
1958
1.10
0.45
2.6
2.4
79.14
76.15
nmol/l
0.75
197
1754
63
556
1.15
0.45
1.5
1.5
—
—
—
0
0
51
443
1.17
0.44
2.9
4.7
4.96
37.77
ug/l
1.12
42
377
16
208
0.76
0.44
1.9
1.9
—
—
—
0
0
16
208
0.76
0.44
1.8
1.8
—
—
—
0
0
16
208
0.76
0.44
2.0
1.9
—
—
—
0
0
41
350
1.19
0.44
1.2
1.2
—
—
—
0
0
9
129
0.69
0.44
29.3
11.2
—
—
—
0
0
14
104
1.36
0.43
3.9
4.4
—
—
—
0
0
6
95
0.63
0.42
1.5
1.4
—
—
—
0
0
16
206
0.77
0.42
2.0
2.0
—
—
—
0
0
11
79
1.40
0.41
4.3
1.7
—
—
—
0
0
21
168
1.26
0.41
1.0
1.1
1.53
1.54
g/l
0.09
21
168
0
17
0.00
0.40
0.0
3.5
—
—
—
0
0
0
19
0.00
0.39
0.0
3.3
—
—
—
0
0
9
66
1.37
0.38
1.0
1.3
—
—
—
0
0
54
478
1.15
0.38
1.8
1.8
—
—
—
0
0
73
660
1.12
0.38
2.7
2.4
20.06
23.43
%
1.51
67
620
11
147
0.74
0.38
2.0
3.0
—
—
—
0
0
82
748
1.12
0.37
2.7
2.4
12.80
13.54
umol/l
0.38
74
698
9
122
0.73
0.35
1.2
1.2
—
—
—
0
0
9
125
0.71
0.35
1.1
1.2
—
—
—
0
0
13
166
0.78
0.33
3.0
3.6
556.83
200.53
mg/l
—
6
68
21
173
1.22
0.33
1.0
1.1
—
—
—
0
0
7
53
1.33
0.31
1.0
1.1
—
—
—
0
0
7
55
1.28
0.30
2.0
2.3
—
—
—
0
0
123
1304
0.92
0.30
1.5
1.5
—
—
—
0
0
8
106
0.75
0.29
2.8
3.6
31.50
35.21
umol/l
—
8
97
40
355
1.14
0.29
1.8
1.7
3.62
3.46
mmol/l
0.36
25
262
48
432
1.12
0.28
3.9
3.3
1.45
1.87
mmol/l
0.45
42
369
19
158
1.21
0.28
2.6
2.7
—
—
—
0
0
11
85
1.30
0.28
1.5
1.3
0.85
0.87
nmol/l
0.06
11
72
41
366
1.13
0.28
1.7
1.5
—
—
—
0
0
155
1478
1.07
0.27
3.7
3.7
—
0.67
—
0
6
194
1865
1.07
0.27
2.2
1.9
1.42
1.37
mmol/l
0.37
178
1570
87
930
0.92
0.26
2.4
3.1
0.63
0.79
ug/l
1.68
57
579
199
1918
1.06
0.25
2.2
2.1
95.98
96.14
pmol/l
0.02
114
999
61
562
1.10
0.25
1.8
1.6
—
—
—
0
0
56
514
1.10
0.24
1.2
1.4
—
—
—
0
0
5
38
1.32
0.23
1.2
1.5
—
—
—
0
0
201
1943
1.06
0.23
6.6
6.7
1.20
1.21
mmol/l
1.25
195
1804
5
41
1.22
0.22
1.2
1.0
—
—
—
0
0
5
41
1.22
0.22
1.2
1.1
—
—
—
0
0
5
42
1.19
0.21
1.4
1.5
1095.00
1891.63
e6/l
—
5
27
0
11
0.00
0.21
0.0
6.5
—
8.18
—
0
11
0
11
0.00
0.21
0.0
3.3
—
46.55
—
0
11
0
11
0.00
0.21
0.0
3.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
19.29
—
0
10
5
43
1.16
0.21
2.8
2.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
44.41
—
0
13
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
21
240
0.87
0.21
1.0
1.1
—
—
—
0
0
89
842
1.07
0.20
3.5
2.9
488.79
534.34
mosm/kgh2o
1.36
84
733
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
3.2
—
—
—
0
0
6
49
1.23
0.20
1.2
1.3
—
—
—
0
0
159
1647
0.95
0.19
4.9
3.9
28.34
102.73
e6/l
2.25
136
1128
15
128
1.18
0.18
1.6
1.4
212.22
294.03
ug/g
—
10
78
191
1966
0.95
0.18
18.7
11.2
0.00
0.00
e9/l
0.15
175
1607
7
58
1.21
0.18
1.4
1.3
—
—
—
0
0
7
63
1.11
0.17
1.3
1.9
—
—
—
0
0
16
141
1.14
0.14
1.0
1.2
106.00
90.67
titre
—
5
15
61
579
1.06
0.13
2.7
2.4
128.18
109.47
ug/g
0.18
50
464
43
458
0.93
0.13
1.7
1.4
—
—
—
0
0
151
1474
1.03
0.11
4.1
3.3
2.34
2.35
mmol/l
0.35
144
1337
14
125
1.12
0.10
1.1
1.1
—
—
—
0
0
5
46
1.09
0.09
1.0
1.1
—
—
—
0
0
10
87
1.15
0.09
1.0
1.0
—
—
—
0
0
5
60
0.83
0.08
1.2
1.3
0.52
0.54
nmol/l
—
5
55
20
185
1.08
0.08
1.8
1.9
—
—
—
0
0
6
71
0.84
0.07
1.5
1.3
—
—
—
0
0
20
214
0.93
0.07
1.2
1.1
—
101.57
—
0
7
9
88
1.02
0.07
1.1
1.3
—
—
—
0
0
45
433
1.04
0.06
1.4
1.4
—
—
—
0
0
8
95
0.84
0.06
2.5
2.7
—
—
—
0
0
9
105
0.85
0.06
1.0
1.2
—
—
—
0
0
30
286
1.05
0.06
1.5
1.2
—
—
—
0
0
42
407
1.03
0.04
1.8
2.0
0.00
0.00
estimate
-0.00
16
87
10
91
1.10
0.04
1.0
1.1
—
—
—
0
0
20
190
1.05
0.04
1.3
1.7
—
—
—
0
0
35
361
0.97
0.03
1.6
2.4
6.05
6.13
ph
0.21
22
242
147
1456
1.01
0.03
4.5
3.2
20.55
96.44
e6/l
0.96
132
1078
10
93
1.08
0.02
3.7
2.6
55.80
58.98
%
—
10
93
14
144
0.97
0.00
1.8
1.7
174.57
219.90
pmol/l
1.32
14
135
28
285
0.98
0.00
1.4
1.2
201.64
150.59
u/ml
0.23
12
113
74
745
0.99
0.00
1.7
1.7
—
—
—
0
0
6
65
0.92
0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
8.23
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
402.00
—
0
5
5
49
1.02
-0.00
2.8
3.5
2.86
3.41
nmol/l
—
5
49
0
6
0.00
-0.00
0.0
1.2
—
66.43
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
18.93
—
0
6
0
9
0.00
-0.00
0.0
1.0
—
0.02
—
0
9
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.13
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
41.67
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
62.00
—
0
6

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_TULARAEMIA and mortality.

Females

Parameter HR [95% CI] p-value
AB1_TULARAEMIA 0.971 [0.78, 1.21] 0.798
Birth year 0.996 [0.99, 1.0] 0.411

During the follow-up period (1.1.1998 — 31.12.2019), 131 out of 1400 females with AB1_TULARAEMIA died.

Males

Parameter HR [95% CI] p-value
AB1_TULARAEMIA 0.804 [0.68, 0.95] 0.011
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 193 out of 1871 males with AB1_TULARAEMIA died.

Mortality risk

Mortality risk for people of age

years, who have AB1_TULARAEMIA.

N-year risk Females Males
1 0.079% 0.134%
5 0.564% 0.855%
10 1.485% 2.14%
15 2.888% 4.126%
20 4.936% 7.341%

Relationships between endpoints

↥

Index endpoint: AB1_TULARAEMIA – Tularaemia

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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