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Certain zoonotic bacterial diseases

DOID EFO Endpoint Browser PheWeb

AB1_ZOONOTIC_BACTERIAL

Yersinia pestis infectious disease: Plague is a severe bacterial infection caused by the gram-negative bacterium Yersinia pestis.

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A20-A28
  • Hospital discharge: ICD-9 — 02[0-7]|B783A
  • Hospital discharge: ICD-8 — 02[0-7]
  • Cause of death: ICD-10 — A20-A28
  • Cause of death: ICD-9 — 02[0-7]|B783A
  • Cause of death: ICD-8 — 02[0-7]

2 out of 7 registries used, show all original rules.

779

4. Check minimum number of events

None

779

5. Include endpoints

779

6. Filter based on genotype QC (FinnGen only)

695

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2

Similar endpoints

↥

List of similar endpoints to Certain zoonotic bacterial diseases based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6494 3019 3435
Only index persons 5630 2662 2968
Unadjusted period prevalence (%)
Whole population 0.09 0.09 0.10
Only index persons 0.11 0.10 0.11
Median age at first event (years)
Whole population 47.98 48.65 47.21
Only index persons 45.99 46.97 45.11

-FinnGen-

Key figures

All Female Male
Number of individuals 695 356 339
Unadjusted period prevalence (%) 0.14 0.13 0.16
Median age at first event (years) 51.10 48.72 53.61

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
715
Matched controls
7150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A21.9
ICD-10 Finland
Tularaemia, unspecified
3395.0
271.8
245
*
A21.0
ICD-10 Finland
Ulceroglandular tularaemia
+∞
146.0
135
*
J01MA02
ATC
ciprofloxacin; systemic
4.3
79.8
437
1922
R50.9
ICD-10 Finland
Fever, unspecified
3.5
44.6
191
668
A21.2
ICD-10 Finland
Pulmonary tularaemia
+∞
32.5
31
*
A26.0
ICD-10 Finland
Cutaneous erysipeloid
+∞
27.3
26
*
A21.8
ICD-10 Finland
Other forms of tularaemia
+∞
24.1
23
*
A21
ICD-10 Finland
Tularaemia
+∞
18.8
18
*
0210A
ICD-9 Finland
Tularaemia, Ulceroglandular tularaemia
+∞
16.7
16
*
J17.0*A21.2
ICD-10 Finland
Pneumonia (due to)(in) tularaemia
+∞
15.7
15
*
A98.5
ICD-10 Finland
Haemorrhagic fever with renal syndrome
5.0
14.6
32
67
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
14.1
84
342
0219X
ICD-9 Finland
Tularaemia, Unspecified tularaemia
+∞
13.6
13
*
02100
ICD-8 Finland
Tularaemia, Glanduraris sive ulceroglandularis
+∞
13.6
13
*
A28.9
ICD-10 Finland
Zoonotic bacterial disease, unspecified
+∞
12.5
12
*
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.6
11.5
27
60
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
11.4
173
1025
A46
ICD-10 Finland
Erysipelas
2.0
10.6
121
648
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
10.5
172
1041
WX720
NOMESCO Finland
Own respiration
2.9
10.4
50
181
A25.1
ICD-10 Finland
Streptobacillosis
111.6
10.4
11
*
0218X
ICD-9 Finland
Tularaemia, Other specified tularaemia
+∞
10.4
10
*
A28.19
ICD-10 Finland
Other or indefinite cat-scratch fever
+∞
10.4
10
*
A21.7
ICD-10 Finland
Generalized tularaemia
+∞
10.4
10
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
10.2
125
687
UDC00
NOMESCO Finland
Ear microscopy
2.5
9.9
64
270
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
9.6
93
468
0270X
ICD-9 Finland
Other zoonotic bacterial diseases, Listeriosis[LISTERIOSIS ALIA (EI SYNNYNNÄINEN)]
+∞
9.4
9
*
A27.9
ICD-10 Finland
Leptospirosis, unspecified
+∞
9.4
9
*
A26.9
ICD-10 Finland
Erysipeloid, unspecified
+∞
9.4
9
*
WVA20, ,
SPAT
3.1
8.8
36
119
A28
ICD-10 Finland
Other zoonotic bacterial diseases, not elsewhere classified
50.6
8.7
10
*
SPAT1044
SPAT
Tympanometry
4.0
8.5
24
62
XQ855, ,
SPAT
6.6
8.2
20
31
SPAT1263
SPAT
Sampling
1.6
8.1
290
2145
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
3.2
8.1
32
104
WX704
NOMESCO Finland
Intubation
2.3
8.0
64
298
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
7.7
334
2577
J01AA02
ATC
doxycycline; systemic
1.6
7.4
529
4545
A24.1
ICD-10 Finland
Acute and fulminating melioidosis
+∞
7.3
7
*
02109
ICD-8 Finland
Tularaemia, Unspecified
+∞
7.3
7
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.1
7.2
70
353
TPH07
NOMESCO Finland
Cathetrisation of artery
1.9
6.9
85
467
J01MA12
ATC
levofloxacin; systemic
1.7
6.8
133
839
JN4AD
NOMESCO Finland
Body CT examination
1.9
6.6
86
480
J01MA14
ATC
moxifloxacin; systemic
2.1
6.5
65
331
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
6.3
200
1423
XQ858, ,
SPAT
9.4
6.3
12
13
M49.1*A23.9
ICD-10 Finland
Brucella spondylitis
+∞
6.3
6
*
A21.1
ICD-10 Finland
Oculoglandular tularaemia
+∞
6.3
6
*
02107
ICD-8 Finland
Tularaemia, Suspecta
+∞
6.3
6
*
SPAT1255
SPAT
Intravenous administration of medicine
2.2
6.2
49
227
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.4
6.2
43
189
WYA20, ,
SPAT
8.7
6.1
12
14
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
6.0
184
1298

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
55
6
99.20
50.60
1.6
1.2
848.33
—
titre
—
24
0
283
1779
1.98
16.63
5.0
4.5
—
—
—
0
0
28
63
4.58
11.75
1.2
1.1
—
—
—
0
0
384
2959
1.64
9.57
7.5
6.4
8.88
8.89
%
0.03
372
2797
259
1816
1.67
9.30
4.2
3.3
0.00
0.06
estimate
0.69
75
550
388
3013
1.63
9.25
7.3
6.4
26.87
27.43
%
0.47
374
2876
382
2961
1.62
9.13
7.4
6.3
2.63
2.87
%
1.51
368
2792
381
2955
1.62
9.05
7.5
6.4
0.69
0.69
%
0.03
369
2781
291
2124
1.62
8.79
3.7
3.2
32.10
33.39
u/l
0.23
277
2011
186
1224
1.70
8.34
5.0
4.0
141.07
412.82
ng/l
1.78
148
956
379
2975
1.58
8.27
7.2
6.2
58.43
57.35
%
1.01
371
2854
28
91
3.16
7.08
1.4
1.4
—
—
—
0
0
28
91
3.16
7.08
1.4
1.4
—
—
—
0
0
28
91
3.16
7.08
1.4
1.4
—
—
—
0
0
28
91
3.16
7.08
1.4
1.4
—
—
—
0
0
348
2742
1.52
7.05
6.1
5.0
35.56
35.76
g/l
0.27
333
2579
143
928
1.68
6.61
2.2
2.1
—
—
—
0
0
392
3197
1.50
6.55
7.1
6.2
0.60
0.59
e9/l
0.73
359
2761
393
3211
1.50
6.48
7.1
6.2
0.04
0.04
e9/l
0.47
361
2778
403
3310
1.50
6.48
7.2
6.4
0.18
0.19
e9/l
0.63
372
2913
398
3268
1.49
6.35
7.1
6.2
1.80
1.90
e9/l
1.03
369
2902
262
1984
1.51
6.19
2.8
2.6
53.62
62.40
u/l
1.70
252
1851
196
1422
1.52
5.58
5.6
4.8
—
—
—
0
0
356
2906
1.45
5.57
13.6
13.6
1.26
1.24
inr
0.15
315
2422
90
539
1.77
5.53
4.5
4.7
1.00
0.60
%
0.81
32
174
90
549
1.73
5.19
5.2
5.2
0.45
0.17
%
0.29
29
148
31
128
2.49
5.11
1.2
1.3
—
—
—
0
0
92
568
1.71
5.08
4.7
4.8
1.83
0.95
%
0.79
30
193
87
538
1.70
4.78
4.5
4.9
0.08
0.13
%
0.34
25
163
243
1890
1.43
4.74
3.4
3.2
—
—
—
0
0
85
526
1.70
4.66
3.4
2.7
10.00
10.98
g/l
1.43
80
484
424
3651
1.40
4.50
5.7
5.3
6.83
6.67
mmol/l
0.81
403
3458
28
118
2.43
4.45
1.2
1.3
151.60
162.90
au/ml
—
5
34
415
3568
1.39
4.41
10.5
9.5
4.20
4.10
e9/l
0.34
385
3125
196
1485
1.44
4.35
4.0
4.0
1.02
1.02
kg/l
0.49
149
1000
305
2501
1.38
4.28
4.5
3.8
0.01
0.03
estimate
0.50
79
577
17
56
3.09
4.26
1.2
1.1
—
—
—
0
0
43
221
2.01
4.25
1.1
1.3
—
—
—
0
0
111
758
1.55
4.09
6.5
8.7
5.04
5.11
kpa
0.36
105
731
110
759
1.53
3.87
6.5
8.7
11.39
12.18
kpa
0.96
104
736
109
751
1.53
3.86
6.6
8.8
7.42
7.42
ph
0.74
77
437
21
83
2.58
3.83
2.3
2.2
31.00
32.43
pg
0.60
21
83
384
3304
1.35
3.82
4.5
3.9
0.00
4.82
estimate
0.80
92
702
124
880
1.49
3.82
1.4
1.3
441.38
523.20
titre
0.32
29
200
69
428
1.68
3.77
1.9
1.6
1.47
1.49
g/l
0.03
63
397
170
1290
1.42
3.68
1.8
1.7
458.33
27077937.11
pmol/l
1.21
148
1071
365
3131
1.34
3.64
8.3
7.2
1.21
1.21
mmol/l
0.20
326
2727
107
745
1.51
3.61
6.6
8.8
1.82
0.86
mmol/l
1.87
81
620
27
125
2.21
3.52
3.3
4.2
20.23
25.96
mg/l
0.29
18
88
6
6
10.07
3.50
5.3
3.8
0.28
0.17
%
—
6
6
19
75
2.58
3.49
2.9
1.9
13.17
13.15
%
0.03
19
75
28
134
2.13
3.38
1.1
1.3
322.36
268.30
u/ml
0.37
14
71
107
758
1.48
3.32
3.0
2.8
1.82
1.83
%
0.02
102
688
79
524
1.57
3.32
2.6
2.8
65.73
67.18
g/l
0.97
74
484
382
3333
1.31
3.23
4.5
3.9
0.00
0.48
estimate
0.52
88
646
453
4049
1.32
3.21
5.5
4.7
861.47
1296.77
e6/l
0.21
17
69
42
237
1.82
3.21
1.4
1.1
—
—
—
0
0
157
1216
1.37
2.97
1.9
2.0
—
—
—
0
0
373
3269
1.29
2.95
4.5
3.8
0.00
0.00
estimate
-0.00
91
688
377
3313
1.29
2.90
7.8
6.6
11.77
11.47
umol/l
0.17
365
3153
108
789
1.43
2.87
2.8
3.0
6.96
4.87
e9/l
0.40
98
689
136
1037
1.38
2.83
1.2
1.3
5.75
10.29
u/ml
0.48
51
391
252
2109
1.30
2.79
7.2
6.0
—
—
—
0
0
468
4242
1.30
2.78
4.4
4.1
—
0.10
—
0
10
113
1489
0.71
2.76
4.0
3.7
—
0.18
—
0
17
60
393
1.57
2.69
4.9
5.9
—
—
—
0
0
130
993
1.38
2.67
2.7
2.4
2.33
2.31
g/l
0.18
119
927
333
2905
1.27
2.63
3.1
2.9
—
—
estimate
—
0
0
65
437
1.54
2.61
2.2
2.5
—
—
—
0
0
508
4677
1.30
2.56
10.0
8.3
77.72
78.57
u/l
0.14
492
4440
6
11
5.49
2.55
2.7
1.9
2.50
2.91
%
—
6
11
19
89
2.17
2.46
1.1
1.2
—
—
—
0
0
36
212
1.74
2.44
4.7
3.6
28.52
62.58
mg/l
1.09
31
179
36
212
1.74
2.44
4.7
3.6
35.58
77.50
mg/l
0.80
31
177
302
2637
1.25
2.27
3.7
3.5
6.21
6.21
ph
0.00
198
1477
33
194
1.73
2.26
4.3
3.4
1.78
2.38
ratio
0.36
23
107
26
142
1.86
2.26
3.3
1.3
18.85
13.83
e6/l
0.10
20
105
5
9
5.58
2.21
1.2
1.3
—
—
—
0
0
534
4983
1.28
2.21
25.4
20.6
333.67
332.60
g/l
1.94
528
4960
25
137
1.85
2.16
1.8
1.6
—
—
—
0
0
78
568
1.42
2.14
7.4
6.5
10.65
9.76
mmol/l
0.41
73
544
228
1939
1.26
2.13
2.8
2.2
177.47
272.28
u/l
0.90
215
1843
91
683
1.38
2.10
6.0
9.2
95.34
95.52
%
0.07
86
661
176
1454
1.28
2.09
1.7
1.7
1.11
1.28
mg/l
0.45
145
1131
88
659
1.38
2.06
3.9
3.3
7.39
7.38
ph
0.68
62
367
24
133
1.83
2.01
3.6
1.3
—
—
—
0
0
267
2324
1.24
2.01
3.5
3.2
—
—
—
0
0
141
1138
1.30
2.00
1.2
1.3
22.29
31.43
iu/ml
0.66
49
351
630
6037
1.37
1.97
23.6
19.0
139.43
139.65
mmol/l
1.29
623
5925
199
1679
1.26
1.97
2.6
2.2
2.71
2.90
mg/l
0.61
178
1449
14
64
2.21
1.95
5.2
1.2
—
—
—
0
0
630
6045
1.35
1.88
24.2
19.2
3.99
3.98
mmol/l
0.63
623
5922
24
137
1.78
1.85
4.0
3.3
—
—
—
0
0
77
581
1.36
1.74
2.8
2.9
71.80
70.99
e9/l
0.06
66
439
83
634
1.35
1.74
3.8
3.3
1.61
1.81
mmol/l
0.22
72
542
96
752
1.32
1.70
1.8
1.7
—
—
—
0
0
6
19
3.18
1.66
1.0
1.6
27.50
27.32
%
—
6
19
127
1538
0.79
1.66
3.3
2.5
—
—
—
0
0
21
120
1.77
1.64
3.5
2.8
31.40
8.94
pmol/l
0.64
21
120
619
5952
1.30
1.60
21.6
16.3
28.97
24.22
mg/l
2.19
556
4913
167
1415
1.24
1.58
4.0
2.7
4.78
6.04
e6/l
0.61
157
1290
114
924
1.28
1.58
2.9
2.4
19.39
23.30
%
2.82
106
871
217
1890
1.21
1.57
5.0
4.0
7.40
7.40
ph
0.21
183
1350
12
57
2.12
1.55
1.2
1.1
—
—
—
0
0
5
125
0.40
1.51
2.0
1.5
—
—
—
0
0
5
126
0.39
1.51
1.8
1.6
—
—
—
0
0
211
1843
1.21
1.47
6.7
6.4
—
—
—
0
0
10
45
2.24
1.47
1.2
3.0
15.03
16.33
%
—
10
45
128
1063
1.25
1.45
2.9
2.4
11.65
13.33
umol/l
1.88
117
998
6
22
2.74
1.43
1.7
1.2
—
1.20
—
0
5
125
1038
1.25
1.42
1.7
1.7
1305.44
1173.09
nmol/l
0.51
105
793
9
40
2.27
1.40
1.0
1.3
—
—
—
0
0
11
53
2.09
1.39
1.5
1.2
—
—
—
0
0
9
41
2.21
1.37
1.3
1.3
—
—
—
0
0
215
1895
1.19
1.35
3.3
3.2
1420.91
1280.72
ng/l
0.18
188
1612
83
1031
0.78
1.34
3.1
3.0
2.27
2.38
e6/l
0.03
50
491
323
2949
1.17
1.33
3.6
3.0
136.93
124.61
ug/l
0.41
302
2754
268
2413
1.18
1.31
4.4
3.9
55.01
71.41
ng/l
0.22
174
1744
155
1329
1.21
1.31
1.6
1.4
2.53
2.49
g/l
0.10
115
828
20
122
1.66
1.28
4.0
3.9
2.25
2.77
mmol/l
0.32
15
85
493
4666
1.18
1.28
4.8
4.3
14.57
14.80
pmol/l
1.29
465
4263
61
469
1.33
1.27
3.5
3.9
83.79
81.30
ng/l
0.09
53
415
575
5520
1.21
1.26
5.7
5.3
1.83
1.89
mu/l
0.65
550
5093
647
6292
1.30
1.25
26.2
20.9
78.76
78.12
umol/l
0.15
642
6219
182
1591
1.19
1.25
3.4
2.8
350.24
344.10
umol/l
0.31
169
1398
6
25
2.41
1.24
1.0
1.2
5.32
6.71
mmol/l
—
6
25
20
124
1.63
1.22
4.2
4.2
233.80
2306.12
u/ml
0.54
15
117
29
197
1.49
1.21
1.2
1.2
101.25
99.05
titre
—
8
21
6
26
2.32
1.19
1.2
1.2
—
21.33
—
0
6
6
26
2.32
1.19
1.7
2.3
—
—
—
0
0
10
50
2.01
1.17
1.1
1.9
38.74
39.75
%
—
10
50
19
118
1.63
1.16
1.0
1.1
—
—
—
0
0
15
87
1.74
1.16
2.3
2.8
—
—
—
0
0
214
2383
0.85
1.14
1.9
2.1
—
—
—
0
0
12
65
1.86
1.14
1.1
1.3
—
—
—
0
0
16
96
1.68
1.11
2.7
2.5
—
—
—
0
0
7
31
2.27
1.10
1.3
2.3
478.43
729.29
u/ml
—
7
31
7
32
2.20
1.08
1.0
1.4
123.57
153.86
nmol/l
—
7
32
7
33
2.13
1.05
1.9
1.6
51.71
55.89
ug/l
—
7
33
91
757
1.23
1.05
1.8
1.6
—
—
—
0
0
9
47
1.93
1.02
1.2
3.0
8.04
8.00
mmol/l
—
9
47
31
224
1.40
0.98
4.0
2.2
3903.53
6281.50
u/l
0.23
14
94
17
108
1.59
0.97
3.2
1.6
—
—
—
0
0
640
6246
1.24
0.96
14.7
12.0
27.68
26.58
u/l
0.83
630
6083
62
501
1.26
0.93
1.6
1.5
—
—
—
0
0
6
27
2.23
0.93
1.0
1.0
—
—
—
0
0
11
183
0.59
0.92
26.7
10.2
—
—
—
0
0
6
28
2.15
0.91
1.0
1.4
—
—
—
0
0
71
585
1.24
0.91
2.4
2.3
12.86
13.42
nmol/l
0.23
65
539
45
571
0.77
0.90
4.4
4.2
7.29
7.35
ph
0.57
38
412
169
1512
1.15
0.87
1.2
1.3
0.86
1.60
u/ml
1.19
51
415
8
43
1.87
0.87
3.0
3.0
0.88
0.81
index
—
8
43
79
662
1.22
0.87
1.5
1.5
—
—
—
0
0
235
2159
1.13
0.82
3.6
3.4
7.57
7.79
mmol/l
0.33
215
1825
6
32
1.88
0.82
2.3
3.8
87.33
135.97
nmol/l
—
6
32
42
331
1.29
0.79
1.2
1.2
—
—
—
0
0
0
25
0.00
0.79
0.0
1.5
—
—
—
0
0
435
4152
1.12
0.79
3.9
3.4
47.00
50.16
u/l
0.39
409
3920
7
125
0.56
0.78
1.4
1.5
—
—
—
0
0
17
244
0.69
0.76
4.1
4.0
25.77
24.90
mmol/l
0.58
17
228
6
34
1.77
0.76
1.0
1.1
—
0.45
—
0
10
9
53
1.71
0.75
2.4
1.6
1.07
1.06
promille
—
9
40
9
54
1.68
0.74
1.0
1.1
100.33
99.69
pmol/l
—
9
54
122
1081
1.16
0.73
4.5
3.1
0.82
0.82
mmol/l
0.02
117
1026
15
100
1.51
0.73
1.1
1.2
2.33
6.52
u/ml
—
6
44
230
2127
1.12
0.72
4.0
3.4
2.35
2.35
mmol/l
0.04
216
1930
92
799
1.17
0.71
1.5
1.4
—
—
—
0
0
9
145
0.62
0.70
1.2
1.3
—
—
—
0
0
17
118
1.45
0.70
3.8
2.6
—
—
—
0
0
86
745
1.18
0.69
2.7
2.8
8.60
8.00
umol/l
0.08
76
658
74
860
0.84
0.68
1.4
1.2
—
—
—
0
0
7
43
1.63
0.67
1.1
1.2
209.40
176.05
pmol/l
—
7
43
111
1246
0.87
0.66
2.6
3.1
0.64
0.77
ug/l
1.47
73
765
99
871
1.16
0.66
7.1
5.6
1.04
1.03
mmol/l
0.15
94
808
296
2786
1.11
0.66
2.3
2.1
98.60
95.91
pmol/l
0.41
172
1475
5
28
1.79
0.66
4.2
1.6
2.04
1.93
umol/l
—
5
22
18
129
1.41
0.64
1.0
1.1
—
—
—
0
0
5
30
1.67
0.61
1.0
1.1
—
—
—
0
0
586
5725
1.13
0.61
5.0
5.1
5.93
5.96
mmol/l
0.24
558
5255
0
20
0.00
0.60
0.0
1.2
—
357.17
—
0
12
598
5852
1.13
0.59
5.3
5.1
4.61
4.59
mmol/l
0.27
571
5471
18
242
0.74
0.59
2.9
3.6
505.86
237.11
mg/l
—
7
101
200
1859
1.11
0.57
1.8
1.7
20.33
20.22
nmol/l
0.03
181
1571
214
1996
1.10
0.57
3.7
3.5
39.70
53.58
mg/l
0.58
151
1311
14
98
1.44
0.57
4.0
3.2
3.22
4.46
e9/l
2.65
14
98
58
496
1.18
0.56
6.3
3.7
—
—
—
0
0
15
107
1.41
0.55
1.2
1.3
—
—
—
0
0
22
168
1.32
0.55
2.6
1.9
3.53
4.11
iu/l
0.24
11
64
12
82
1.47
0.54
1.3
1.3
—
—
—
0
0
9
60
1.51
0.54
2.0
2.5
—
—
—
0
0
595
5830
1.12
0.54
5.1
5.0
1.43
1.45
mmol/l
0.45
568
5417
34
277
1.24
0.53
1.7
1.9
—
—
—
0
0
224
2100
1.10
0.53
5.6
5.3
2.37
2.47
ug/l
0.07
210
1894
38
314
1.22
0.53
2.6
2.3
—
—
—
0
0
655
6462
1.16
0.50
31.1
24.5
249.54
247.90
e9/l
0.24
648
6355
37
307
1.22
0.50
1.8
2.1
0.00
0.01
estimate
0.50
19
100
11
156
0.70
0.50
1.6
1.8
—
—
—
0
0
29
234
1.25
0.50
1.1
1.1
—
—
—
0
0
10
67
1.50
0.50
1.9
2.2
—
—
—
0
0
72
635
1.15
0.49
3.4
4.6
10.62
30.67
ug/l
0.78
54
538
25
311
0.80
0.48
3.7
3.8
—
—
—
0
0
295
2811
1.08
0.48
2.7
2.5
78.90
76.51
nmol/l
0.68
279
2525
605
5943
1.12
0.48
5.8
5.7
2.71
2.68
mmol/l
0.34
571
5530
655
6466
1.15
0.47
31.4
24.9
40.15
40.46
%
0.95
649
6400
655
6466
1.15
0.47
31.0
24.4
4.44
4.50
e12/l
2.50
649
6337
217
2044
1.09
0.47
4.4
4.2
7.40
9.57
mg/mmol
0.38
147
1284
655
6467
1.15
0.46
31.1
24.5
6.75
6.76
e9/l
0.04
649
6337
8
117
0.68
0.46
1.1
1.1
—
—
—
0
0
7
49
1.43
0.46
1.0
1.0
—
—
—
0
0
218
2059
1.08
0.44
4.1
3.3
22.95
90.51
e6/l
1.35
187
1552
63
559
1.14
0.41
3.7
2.7
4.69
4.45
kpa
0.37
57
536
5
33
1.52
0.41
1.0
1.1
—
0.32
—
0
10
8
59
1.36
0.41
1.3
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
3.2
—
—
—
0
0
5
34
1.47
0.40
2.8
2.0
414.20
70.58
umol/l
—
5
19
27
223
1.22
0.40
1.1
1.1
0.91
0.90
g/l
0.06
27
223
268
2561
1.07
0.40
2.1
1.9
1.44
1.34
mmol/l
1.11
238
2157
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
8
61
1.31
0.39
1.1
1.3
—
—
—
0
0
51
448
1.15
0.39
3.3
3.6
7.42
7.42
ph
0.11
46
377
9
66
1.37
0.38
1.0
1.2
—
—
—
0
0
9
67
1.35
0.38
1.3
1.4
—
—
—
0
0
293
2814
1.07
0.38
7.1
6.6
1.20
1.21
mmol/l
0.62
284
2592
130
1211
1.09
0.37
3.4
2.9
503.63
535.98
mosm/kgh2o
0.90
119
1061
8
116
0.69
0.37
1.1
1.1
—
—
—
0
0
10
72
1.39
0.37
1.8
2.3
—
—
—
0
0
14
178
0.78
0.34
1.3
1.2
—
—
—
0
0
12
91
1.32
0.34
1.3
1.8
—
—
—
0
0
194
2038
0.93
0.33
2.9
2.5
—
—
—
0
0
568
5591
1.08
0.33
6.6
6.4
39.97
39.38
mmol/mol
0.83
548
5259
20
164
1.23
0.33
3.6
3.0
4.27
2.27
index
0.93
11
97
19
155
1.23
0.32
3.6
4.6
—
—
—
0
0
33
285
1.17
0.32
1.8
2.1
1.32
1.44
g/l
0.25
23
258
118
1257
0.93
0.30
2.7
2.9
2.46
2.45
mmol/l
0.40
108
1129
8
63
1.27
0.28
3.4
1.4
27.54
29.79
ng/l
—
8
63
110
1034
1.08
0.27
1.7
1.7
—
—
—
0
0
25
215
1.17
0.27
1.0
1.1
1.50
1.53
g/l
0.18
25
215
5
73
0.68
0.26
1.6
1.7
—
—
—
0
0
15
123
1.22
0.25
1.1
1.2
—
—
—
0
0
9
74
1.22
0.25
5.7
4.7
—
—
—
0
0
25
217
1.16
0.24
3.7
1.9
—
—
—
0
0
31
276
1.13
0.22
1.5
1.7
4.24
8.29
iu/ml
—
5
72
5
40
1.25
0.22
1.2
1.2
8.28
6.68
ug/l
—
5
35
10
79
1.27
0.22
1.3
1.3
—
—
—
0
0
5
42
1.19
0.21
1.4
1.5
141.80
76.74
umol/l
—
5
42
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
3.14
—
0
5
0
12
0.00
0.21
0.0
1.1
—
0.08
—
0
12
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
73
779
0.93
0.21
1.2
1.3
—
—
—
0
0
241
2339
1.05
0.21
4.5
4.0
60.74
113.80
e6/l
0.96
193
1633
5
43
1.16
0.21
1.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.7
—
19.07
—
0
13
0
13
0.00
0.21
0.0
1.5
—
65.08
—
0
13
0
13
0.00
0.21
0.0
1.1
—
44.41
—
0
13
23
261
0.88
0.20
1.4
3.4
18.78
5548.18
u/ml
0.85
18
228
617
6117
1.06
0.20
20.7
14.4
—
—
—
0
0
23
260
0.88
0.19
1.3
1.2
—
—
—
0
0
6
52
1.16
0.19
1.0
1.4
—
—
—
0
0
51
473
1.08
0.19
1.9
1.7
3.54
3.45
mmol/l
0.20
33
338
55
512
1.08
0.18
1.2
1.2
—
—
—
0
0
284
2774
1.04
0.18
17.3
11.3
0.00
0.00
e9/l
0.28
244
2286
17
147
1.16
0.18
1.1
1.2
—
—
—
0
0
561
5554
1.05
0.18
4.4
4.2
1.29
1.29
mmol/l
0.06
531
5117
70
661
1.07
0.17
1.8
1.8
—
—
—
0
0
30
273
1.10
0.16
3.4
1.9
—
—
—
0
0
78
819
0.95
0.15
2.4
2.4
111.12
110.51
ug/g
0.01
66
656
10
84
1.19
0.14
1.3
1.2
—
—
—
0
0
32
346
0.92
0.14
3.4
2.3
0.67
0.61
%
0.32
32
346
8
97
0.82
0.13
1.1
1.2
—
—
—
0
0
30
276
1.09
0.13
3.3
1.7
—
—
—
0
0
30
276
1.09
0.13
3.3
1.9
—
—
—
0
0
15
132
1.14
0.13
4.1
3.0
57.07
59.20
%
0.20
15
132
30
277
1.09
0.13
4.4
1.9
—
—
—
0
0
30
324
0.92
0.12
1.0
1.1
—
—
—
0
0
218
2134
1.03
0.12
3.9
3.7
—
0.71
—
0
7
28
258
1.09
0.12
3.5
1.9
—
—
—
0
0
14
158
0.88
0.12
3.4
2.4
60.51
72.36
ug/min
—
9
90
49
516
0.95
0.11
1.4
1.4
—
—
—
0
0
174
1774
0.97
0.09
3.9
3.2
0.13
0.49
e6/l
5.69
144
1284
47
492
0.95
0.09
1.9
2.5
6.13
6.13
ph
0.01
27
330
6
58
1.03
0.08
1.3
1.4
—
—
—
0
0
6
58
1.03
0.08
1.2
1.1
—
—
—
0
0
54
561
0.96
0.08
1.4
1.4
—
—
—
0
0
7
67
1.05
0.08
9.3
1.4
—
—
—
0
0
7
68
1.03
0.08
1.1
1.3
—
—
—
0
0
8
74
1.08
0.07
1.0
1.1
—
—
—
0
0
14
128
1.10
0.06
1.1
1.3
—
—
—
0
0
74
720
1.03
0.06
1.2
1.4
—
—
—
0
0
20
188
1.07
0.05
4.8
2.7
—
—
—
0
0
177
1792
0.98
0.05
1.5
1.5
—
—
—
0
0
17
181
0.94
0.05
1.2
1.2
—
—
—
0
0
29
302
0.96
0.04
1.1
1.1
—
108.88
—
0
8
63
642
0.98
0.03
1.6
1.5
—
—
—
0
0
57
560
1.02
0.02
7.1
8.7
—
—
—
0
0
183
1841
0.99
0.02
5.0
3.9
0.00
0.01
estimate
1.15
89
635
18
187
0.96
0.01
1.6
1.4
222.60
287.84
ug/g
0.71
12
108
30
307
0.98
0.01
2.1
1.6
0.20
0.32
mg/l
1.12
16
144
59
583
1.01
0.01
1.8
2.1
0.00
0.03
estimate
0.50
18
120
12
116
1.04
0.00
1.7
1.6
—
—
—
0
0
17
166
1.02
0.00
1.2
1.1
—
—
—
0
0
24
237
1.01
0.00
2.8
2.7
—
—
—
0
0
26
263
0.99
0.00
1.7
1.7
—
—
—
0
0
41
412
0.99
0.00
1.3
1.2
252.75
154.61
u/ml
0.48
13
160
43
429
1.00
0.00
1.3
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
7
78
0.90
-0.00
3.0
2.7
4.13
4.01
mmol/l
—
7
78
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
71
0.99
-0.00
3.0
2.4
—
—
—
0
0
7
77
0.91
-0.00
3.0
2.7
1.21
1.19
mmol/l
—
7
77
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.2
—
0.33
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
402.00
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
80
1.00
-0.00
1.1
1.4
0.56
0.57
nmol/l
—
8
75
7
78
0.90
-0.00
3.0
2.7
107.57
105.41
mmol/l
—
7
78
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_ZOONOTIC_BACTERIAL and mortality.

Females

Parameter HR [95% CI] p-value
AB1_ZOONOTIC_BACTERIAL 1.32 [1.11, 1.57] 0.002
Birth year 0.998 [0.99, 1.01] 0.644

During the follow-up period (1.1.1998 — 31.12.2019), 303 out of 1976 females with AB1_ZOONOTIC_BACTERIAL died.

Males

Parameter HR [95% CI] p-value
AB1_ZOONOTIC_BACTERIAL 1.111 [0.96, 1.29] 0.16
Birth year 0.988 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 369 out of 2439 males with AB1_ZOONOTIC_BACTERIAL died.

Mortality risk

Mortality risk for people of age

years, who have AB1_ZOONOTIC_BACTERIAL.

N-year risk Females Males
1 0.128% 0.284%
5 0.806% 1.415%
10 2.18% 3.598%
15 4.413% 6.727%
20 7.549% 11.22%

Relationships between endpoints

↥

Index endpoint: AB1_ZOONOTIC_BACTERIAL – Certain zoonotic bacterial diseases

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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