No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
835 |
4. Check minimum number of eventsNone |
835 |
5. Include endpointsNone |
835 |
6. Filter based on genotype QC (FinnGen only) |
706 |
Control definitions (FinnGen only)
- Control exclude
- AB1_TUBERCULOSIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Respiratory tuberculosis, confirmed
based on the number of shared cases.
Similar with more cases:
- Respiratory tuberculosis, bacteriologically and histologically confirmed
- Respiratory tuberculosis, confirmed and not-confirmed
- Respiratory tuberculosis
- Tuberculosis
- Tuberculosis, IBD comorbidity
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10043 | 3678 | 6041 |
| Only index persons | 5568 | 2240 | 3328 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.11 | 0.17 |
| Only index persons | 0.11 | 0.08 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 65.07 | 68.60 | 63.07 |
| Only index persons | 58.70 | 59.64 | 58.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 706 | 231 | 475 |
| Unadjusted period prevalence (%) | 0.17 | 0.08 | 0.22 |
| Median age at first event (years) | 63.17 | 56.52 | 66.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 749
- Matched controls
- 7490
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
+∞
307.7
304
*
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
+∞
241.0
218
*
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
91.7
169.3
89
11
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
7.0
134.3
269
555
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.6
131.0
228
406
0110A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, BAKTER.VARMA]
+∞
78.5
74
*
A70
ICPC
Tuberculosis
781.1
73.5
71
*
A15.2
ICD-10 Finland
Tuberculosis of lung, confirmed histologically
+∞
68.8
65
*
A15.6
ICD-10 Finland
Tuberculous pleurisy, confirmed bacteriologically and histologically
+∞
58.1
55
*
A15.9
ICD-10 Finland
Respiratory tuberculosis unspecified, confirmed bacteriologically and histologically
532.5
51.1
50
*
A15.3
ICD-10 Finland
Tuberculosis of lung, confirmed by unspecified means
+∞
45.3
43
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.4
44.2
208
769
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
43.2
370
1910
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
64.0
41.7
48
8
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
396.8
38.4
38
*
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
5.0
35.7
81
176
A15.7
ICD-10 Finland
Primary respiratory tuberculosis, confirmed bacteriologically and histologically
+∞
33.6
32
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.3
32.5
91
234
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.9
32.0
75
167
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.1
31.9
158
592
R03BB04
ATC
tiotropium bromide; inhalant
3.1
31.4
162
621
TGC00
NOMESCO Finland
Bronchial lavation
6.1
30.6
55
96
0112A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung with cavitation[TUBERCULOSIS PULMONUM CAVERNOSA, BAKTERIOL.VARMA]
+∞
29.4
28
*
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.7
28.7
100
300
J01MA14
ATC
moxifloxacin; systemic
3.3
27.6
115
387
GD1AD
NOMESCO Finland
Thorax CT examination
3.9
26.1
83
233
1240
FHL
Bronchoscopy
6.6
25.0
41
65
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
7.4
24.4
36
51
A16.2
ICD-10 Finland
Tuberculosis of lung, without mention of bacteriological or histological confirmation
+∞
24.1
23
*
A15.8
ICD-10 Finland
Other respiratory tuberculosis, confirmed bacteriologically and histologically
+∞
24.1
23
*
R04.2
ICD-10 Finland
Haemoptysis
4.4
23.9
63
154
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
5.2
22.3
47
95
J47
ICD-10 Finland
Bronchiectasis
6.0
21.2
38
66
H02AB06
ATC
prednisolone; systemic
2.0
20.1
392
2622
A15.4
ICD-10 Finland
Tuberculosis of intrathoracic lymph nodes, confirmed bacteriologically and histologically
+∞
19.9
19
*
J96.1
ICD-10 Finland
Chronic respiratory failure
4.5
19.0
48
113
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.2
18.7
191
996
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.6
17.8
61
180
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
17.4
395
2735
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
17.1
174
902
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
3.5
17.0
61
185
R03DA04
ATC
theophylline; systemic, rectal
2.7
16.7
95
378
R03AC12
ATC
salmeterol; inhalant
3.1
16.0
69
235
0119A
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, BAKTERIOLOG. VARMA]
+∞
15.7
15
*
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
14.1
15.6
26
19
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.7
15.0
83
325
R03AC02
ATC
salbutamol; inhalant
1.8
14.2
386
2768
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.8
14.1
75
287
H02AB07
ATC
prednisone; oral
2.2
14.1
136
687
R05
ICD-10 Finland
Cough
2.1
13.7
154
824
XG410
NOMESCO Finland
Flow-volume spirometry
3.4
13.6
50
154
1370A
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,TUBERKULOOSIARPI]
+∞
13.6
13
*
A16.1
ICD-10 Finland
Tuberculosis of lung, bacteriological and histological examination not done
+∞
13.6
13
*
R03BB01
ATC
ipratropium bromide; inhalant
2.6
12.5
74
299
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
3.2
12.3
49
159
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
12.3
113
558
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
12.3
227
1434
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
5.4
12.1
24
46
SPAT1254
SPAT
Administration of medicine
2.1
11.6
133
713
R03AK03
ATC
[U] fenoterol and ipratropium bromide
2.3
11.5
89
408
R99
ICPC
Respiratory disease other
4.8
11.5
26
56
J01MA12
ATC
levofloxacin; systemic
1.9
11.5
170
998
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
11.4
345
2497
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
11.4
154
877
J45.1
ICD-10 Finland
Nonallergic asthma
2.6
10.6
63
255
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
4.7
10.5
24
52
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
+∞
10.4
10
*
A18.2
ICD-10 Finland
Tuberculous peripheral lymphadenopathy
+∞
10.4
10
*
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
3.9
9.9
29
77
N05BA02
ATC
chlordiazepoxide; systemic
3.9
9.9
29
77
R50.9
ICD-10 Finland
Fever, unspecified
1.9
9.6
124
692
F10.20
ICD-10 Finland
Alcohol dependence currently independent
4.7
9.6
22
48
M05BA04
ATC
alendronic acid; oral
2.3
9.6
76
352
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
3.4
9.6
35
108
L04AX01
ATC
azathioprine; systemic
3.5
9.5
33
98
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.5
9.5
60
250
0120A
ICD-9 Finland
Other respiratory tuberculosis, Tuberculous pleurisy[TUBERCULOSIS PLEURAE, BAKTERIOLOGISESTI VARMA]
+∞
9.4
9
*
0110X
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, EPÄILTY]
+∞
9.4
9
*
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
9.3
141
828
J01FA06
ATC
roxithromycin; oral
1.6
9.3
287
2060
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.9
9.0
125
713
R06.0
ICD-10 Finland
Dyspnoea
1.7
8.9
218
1471
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
8.8
172
1092
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
3.6
8.7
28
79
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
8.7
152
932
A31.9
ICD-10 Finland
Mycobacterial infection, unspecified
50.6
8.7
10
*
F10.25
ICD-10 Finland
Alcohol dependence continuous use
4.6
8.6
20
44
R03AC03
ATC
terbutaline; inhalant
2.0
8.4
94
498
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
3.7
8.3
26
72
0118A
ICD-9 Finland
Pulmonary tuberculosis, Other specified pulmonary tuberculosis[TUBERCULOSIS PULMONUM ALIA, BAKTERIOLOG.VARMA]
+∞
8.3
8
*
A16.5
ICD-10 Finland
Tuberculous pleurisy, without mention of bacteriological or histological confirmation
+∞
8.3
8
*
A18.1
ICD-10 Finland
Tuberculosis of genitourinary system
+∞
8.3
8
*
0119X
ICD-9 Finland
Pulmonary tuberculosis, unspecified[TUBERCULOSIS PULMONUM NUD, EPÄILTY]
+∞
8.3
8
*
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
4.6
8.2
19
42
Z20.1
ICD-10 Finland
Contact with and exposure to tuberculosis
11.9
8.1
14
12
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
4.3
8.0
20
47
J46
ICD-10 Finland
Status asthmaticus
3.6
7.8
25
71
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
45.5
7.7
9
*
J45.8
ICD-10 Finland
Mixed asthma
3.3
7.7
28
86
R03AL03
ATC
vilanterol and umeclidinium bromide; inhalant
4.6
7.7
18
40
J01AA02
ATC
doxycycline; systemic
1.6
7.6
538
4597
JN4AD
NOMESCO Finland
Body CT examination
2.0
7.6
91
493
R03BA01
ATC
beclometasone; inhalant
1.9
7.6
107
612
B90.0
ICD-10 Finland
Sequelae of central nervous system tuberculosis
80.9
7.4
8
*
L04AA13
ATC
[U] leflunomide
4.2
7.3
19
46
A15
ICD-10 Finland
Respiratory tuberculosis, bacteriologically and histologically confirmed
+∞
7.3
7
*
A16.9
ICD-10 Finland
Respiratory tuberculosis unspecified, without mention of bacteriological or histological confirmation
+∞
7.3
7
*
A18.0
ICD-10 Finland
Tuberculosis of bones and joints
+∞
7.3
7
*
A15.5
ICD-10 Finland
Tuberculosis of larynx, trachea and bronchus, confirmed bacteriologically and histologically
+∞
7.3
7
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.6
7.3
42
168
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
4.4
7.2
18
42
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
6.1
7.1
18
30
L88
ICPC
Rheumatoid/seropositive arthritis
3.0
7.1
31
107
R03BB02
ATC
oxitropium bromide; inhalant
4.3
7.0
18
43
N05CD07
ATC
temazepam; oral
1.8
7.0
121
737
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.5
6.9
44
185
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.8
6.8
34
127
XW000
NOMESCO Finland
Bone marrow biopsy
2.6
6.7
38
151
WNF00
NOMESCO Finland
Infection source and contact determination
10.1
6.5
12
12
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
6.3
6.5
16
26
V03AA01, ,
ATC
4.0
6.5
18
46
A31.89
ICD-10 Finland
Other mycobacterial infections
70.4
6.4
7
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.6
6.4
36
143
R03AC13
ATC
formoterol; inhalant
2.3
6.3
45
199
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
5.6
6.3
17
31
01107
ICD-8 Finland
Pulmonary tuberculosis, Suspecta
+∞
6.3
6
*
A19.1
ICD-10 Finland
Acute miliary tuberculosis of multiple sites
+∞
6.3
6
*
0116A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculous pneumonia [any form][TUBERCULOSIS PULMONUM CUM PNEUMONIA,BAKTER.VARMA]
+∞
6.3
6
*
01101
ICD-8 Finland
Pulmonary tuberculosis, Cavernosa
+∞
6.3
6
*
A18.3
ICD-10 Finland
Tuberculosis of intestines, peritoneum and mesenteric glands
+∞
6.3
6
*
GAC01
NOMESCO Finland
Endoscopic biopsy of pleura
26.9
6.2
8
*
L01BA01
ATC
methotrexate; systemic
2.9
6.2
28
99
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
4.2
6.1
16
39
A02BC02
ATC
pantoprazole; systemic
1.5
6.1
459
3877
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
6.0
174
1208
R81
ICPC
Pneumonia
2.6
6.0
33
129
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
222
237
12.89
197.49
7.1
2.8
—
—
—
0
0
115
68
19.80
142.14
13.3
3.8
—
—
—
0
0
103
163
7.17
63.94
2.9
1.4
—
—
—
0
0
60
88
7.32
39.55
1.2
1.1
—
—
—
0
0
29
28
10.73
26.37
8.9
4.4
—
—
—
0
0
65
156
4.47
25.22
1.8
1.5
1.30
0.15
iu/ml
3.02
21
35
60
140
4.57
24.10
1.5
1.5
—
—
—
0
0
54
121
4.73
22.78
1.5
1.4
—
—
—
0
0
62
163
4.06
21.31
1.7
1.6
—
—
—
0
0
26
11
24.43
18.74
1.7
1.2
—
—
—
0
0
60
172
3.71
18.24
1.7
1.6
—
—
—
0
0
32
59
5.62
16.79
1.5
1.6
—
—
—
0
0
32
64
5.18
15.38
1.4
1.3
15.63
13.83
u/l
0.52
32
59
65
220
3.14
15.23
1.7
2.1
42.23
38.63
u/l
0.71
56
190
43
122
3.68
13.27
1.7
1.5
—
—
—
0
0
177
1011
1.98
13.11
4.8
3.3
0.80
0.82
mmol/l
1.75
170
954
29
63
4.75
12.68
1.8
1.8
—
—
—
0
0
27
58
4.79
11.97
1.8
1.8
—
—
—
0
0
37
103
3.73
11.74
1.6
1.5
—
—
—
0
0
192
1185
1.83
11.02
2.6
1.9
—
—
—
0
0
14
5
28.48
10.75
1.1
1.8
—
—
—
0
0
409
3146
1.66
10.39
16.7
9.3
4.43
4.30
e9/l
0.46
365
2733
22
27
8.36
10.37
1.2
1.2
—
—
—
0
0
402
3080
1.66
10.36
12.1
6.7
10.02
12.30
umol/l
5.54
394
2939
23
49
4.81
10.30
1.7
1.6
—
—
—
0
0
23
49
4.81
10.30
1.7
1.6
—
—
—
0
0
23
49
4.81
10.30
1.7
1.6
—
—
—
0
0
38
118
3.34
10.26
1.8
1.7
—
—
—
0
0
40
136
3.05
9.33
1.4
2.1
13.15
13.26
mg/l
0.02
31
121
136
791
1.88
9.28
5.1
4.2
232.40
251.47
u/l
1.03
131
750
142
854
1.82
8.68
7.0
5.7
1.06
1.03
mmol/l
0.38
133
780
29
87
3.43
8.28
1.7
1.5
—
—
—
0
0
47
187
2.61
8.23
1.5
1.6
—
—
—
0
0
35
119
3.04
8.18
4.6
5.7
227.67
153.31
iu/ml
—
6
13
85
445
2.03
7.85
2.1
1.7
—
—
—
0
0
138
849
1.77
7.76
2.6
1.9
—
—
—
0
0
103
590
1.86
7.31
2.4
2.3
0.19
0.20
g/l
0.88
98
541
99
560
1.88
7.30
1.8
2.6
66.37
66.09
g/l
0.12
87
512
142
896
1.72
7.28
2.4
1.9
—
—
—
0
0
112
664
1.81
7.11
2.8
4.5
21.32
26.89
ug/l
0.13
96
567
158
1034
1.67
7.06
3.4
2.6
2.15
2.24
g/l
1.08
147
950
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
49
218
2.34
6.80
2.2
2.8
0.33
0.34
iu/ml
0.12
23
118
165
1106
1.63
6.69
3.5
2.6
10.75
12.36
umol/l
2.49
155
1022
29
100
2.98
6.65
1.5
1.3
2077.39
1460.60
e6/l
0.74
18
65
148
968
1.66
6.60
3.5
2.6
20.29
22.41
%
1.19
139
899
85
474
1.89
6.54
1.8
1.7
—
—
—
0
0
61
307
2.07
6.28
1.7
1.3
111.68
358.84
u/ml
1.77
55
282
41
175
2.42
6.25
1.4
1.6
—
—
—
0
0
17
32
5.41
6.18
1.4
1.7
802.00
471.52
e6/l
0.67
12
27
16
28
5.81
6.17
1.8
1.7
—
—
—
0
0
16
28
5.81
6.17
1.8
1.7
—
—
—
0
0
16
28
5.81
6.17
1.8
1.7
—
—
—
0
0
26
88
3.02
6.16
1.8
1.5
—
—
—
0
0
341
2724
1.46
6.03
9.0
6.5
1.20
1.21
mmol/l
1.10
317
2488
336
2677
1.46
6.02
6.5
5.2
33.47
34.87
g/l
3.98
311
2495
228
1681
1.51
6.02
3.1
2.3
2.83
3.05
mg/l
0.71
200
1446
14
22
6.46
5.88
1.9
1.8
—
—
—
0
0
14
22
6.46
5.88
1.9
1.8
—
—
—
0
0
14
23
6.18
5.71
1.9
2.2
1354.00
876.22
u/ml
0.44
14
23
14
23
6.18
5.71
1.9
1.7
—
—
—
0
0
121
779
1.66
5.70
8.8
7.5
1.12
1.03
mmol/l
0.09
106
628
28
104
2.76
5.65
1.4
1.3
—
212.50
—
0
8
122
789
1.65
5.64
8.9
7.4
5.05
5.10
kpa
0.22
116
755
122
790
1.65
5.61
8.9
7.4
11.45
11.58
kpa
0.07
117
758
15
28
5.44
5.55
1.8
1.7
—
—
—
0
0
19
57
3.39
5.47
1.2
1.4
—
—
—
0
0
25
90
2.84
5.35
1.6
1.2
32008.00
24274.22
e6/l
0.11
13
51
73
414
1.85
5.35
1.3
1.4
—
—
—
0
0
106
679
1.65
5.08
4.5
3.6
5.79
5.80
kpa
0.06
101
659
62
342
1.89
4.96
1.6
2.0
1.57
1.55
g/l
0.04
57
307
44
217
2.09
4.82
1.3
1.3
—
—
—
0
0
364
3024
1.40
4.81
9.8
7.3
1.21
1.21
mmol/l
0.55
323
2571
102
656
1.64
4.81
4.8
3.6
1.94
2.02
mmol/l
0.07
87
550
14
30
4.73
4.70
1.6
2.0
—
—
—
0
0
18
58
3.16
4.66
4.4
2.7
—
—
—
0
0
458
3976
1.39
4.54
8.4
4.3
18.33
14.08
mm/h
4.64
435
3639
8
8
10.09
4.53
1.4
1.4
—
—
—
0
0
65
381
1.77
4.30
5.1
3.8
1.49
2.04
mmol/l
0.46
53
278
69
413
1.74
4.25
10.6
8.6
24.23
24.42
mmol/l
0.20
69
401
16
51
3.18
4.23
1.3
1.3
—
—
—
0
0
481
4242
1.37
4.13
15.7
8.4
82.56
81.82
u/l
0.09
468
3990
233
1834
1.39
4.09
3.8
3.1
33.30
35.88
u/l
0.46
221
1734
30
136
2.26
4.07
1.4
1.5
—
—
—
0
0
84
541
1.62
3.95
2.0
1.8
1.70
1.57
%
0.78
71
462
90
591
1.59
3.91
8.0
7.1
11.05
11.20
mmol/l
0.06
85
562
38
193
2.02
3.89
2.8
2.1
3.00
8.41
iu/ml
1.63
11
48
47
258
1.88
3.86
2.6
1.9
—
—
—
0
0
232
1844
1.37
3.80
3.0
2.6
61.31
61.58
u/l
0.02
219
1719
10
20
5.05
3.69
1.2
1.4
—
—
—
0
0
25
110
2.32
3.65
1.3
1.3
4.26
3.82
mmol/l
0.56
25
101
32
157
2.08
3.61
2.5
1.5
0.23
0.23
g/l
0.18
32
152
24
107
2.28
3.42
1.5
1.3
—
—
—
0
0
7
10
7.05
3.37
1.1
1.5
—
—
—
0
0
121
876
1.45
3.35
1.4
1.3
58.12
33.79
iu/ml
0.45
37
276
29
143
2.07
3.25
1.6
1.3
—
—
—
0
0
159
1220
1.39
3.17
2.3
1.7
1.25
1.48
mg/l
0.63
126
977
51
307
1.71
3.13
2.5
2.6
35.60
14.99
au/ml
—
5
21
19
80
2.41
3.08
1.3
1.4
155.90
158.75
au/ml
—
10
22
160
1236
1.37
3.06
5.3
4.3
814.12
327.08
ng/l
0.79
135
1056
30
154
1.99
3.03
1.6
1.3
—
—
—
0
0
30
154
1.99
3.03
1.6
1.3
—
—
—
0
0
155
1195
1.37
3.00
2.0
1.8
1111.21
1147.13
nmol/l
0.20
116
902
41
235
1.79
2.99
2.3
1.8
—
—
—
0
0
253
2101
1.31
2.96
4.3
3.3
2670.66
1978.34
ng/l
1.16
228
1812
38
216
1.80
2.85
1.8
1.6
0.33
0.34
mg/l
0.05
21
95
344
2991
1.28
2.78
19.1
18.0
1.28
1.35
inr
1.32
304
2529
12
39
3.11
2.78
1.2
1.6
—
—
—
0
0
12
39
3.11
2.78
1.2
1.6
—
—
—
0
0
30
160
1.91
2.75
2.5
2.1
117.67
128.06
g/l
1.16
18
127
13
48
2.74
2.73
1.5
1.5
0.96
0.94
ratio
—
5
30
13
48
2.74
2.73
1.4
1.5
—
—
—
0
0
13
48
2.74
2.73
1.5
1.5
0.90
1.29
ratio
—
5
30
13
48
2.74
2.73
1.5
1.5
1.04
1.16
ratio
—
5
30
10
29
3.48
2.70
1.0
1.0
—
—
—
0
0
55
353
1.60
2.68
1.7
1.5
—
—
—
0
0
40
236
1.73
2.67
1.6
2.8
1.26
1.06
g/l
0.07
30
207
12
43
2.82
2.65
1.4
1.2
—
82.00
—
0
5
76
530
1.48
2.56
2.3
2.0
397.16
386.87
nmol/l
0.21
68
491
109
814
1.40
2.55
1.4
1.3
15.49
12.96
u/ml
0.11
33
311
6
11
5.49
2.54
1.0
1.3
—
—
—
0
0
6
11
5.49
2.54
1.0
1.4
—
—
—
0
0
175
1408
1.32
2.53
3.6
2.5
—
—
—
0
0
11
37
3.00
2.49
2.0
1.5
—
—
—
0
0
225
1878
1.28
2.47
2.5
2.1
267.08
297.21
u/l
0.14
212
1774
42
258
1.67
2.44
1.9
2.5
3.04
3.04
g/l
0.00
33
231
44
274
1.64
2.43
1.8
2.4
4.18
4.15
g/l
0.08
35
247
44
274
1.64
2.43
1.8
2.4
3.69
3.77
g/l
0.12
35
247
44
274
1.64
2.43
1.8
2.4
7.91
7.43
g/l
0.91
35
247
93
683
1.41
2.40
3.0
2.9
4.91
8.82
umol/l
4.74
81
616
186
1520
1.30
2.39
3.6
3.0
364.37
364.44
umol/l
0.00
161
1315
12
46
2.63
2.37
2.0
1.4
—
—
—
0
0
11
39
2.85
2.35
1.0
1.0
—
—
—
0
0
11
39
2.85
2.35
2.1
1.5
—
—
—
0
0
35
208
1.72
2.31
1.4
3.4
2.56
3.04
ratio
0.20
22
121
449
4881
0.80
2.31
5.3
5.1
1.48
1.42
mmol/l
2.36
413
4445
242
2053
1.26
2.30
3.4
3.5
2.34
2.35
mmol/l
0.68
208
1842
518
5539
0.79
2.28
49.4
28.1
252.38
239.81
e9/l
3.18
510
5415
11
40
2.78
2.28
1.5
1.2
—
—
—
0
0
12
47
2.58
2.28
1.4
1.1
—
—
—
0
0
11
41
2.71
2.21
1.5
1.2
—
—
—
0
0
519
5541
0.79
2.20
49.2
28.1
4.30
4.42
e12/l
4.79
509
5395
519
5541
0.79
2.20
50.2
28.6
38.90
39.74
%
3.15
514
5453
286
2485
1.24
2.19
4.3
3.1
186.94
153.62
ug/l
0.86
267
2292
8
24
3.36
2.18
1.4
1.1
—
—
—
0
0
163
1976
0.78
2.17
4.3
4.8
22.11
21.98
%
0.04
85
1022
6
14
4.31
2.15
1.0
1.1
—
—
—
0
0
11
42
2.64
2.15
1.5
1.2
—
—
—
0
0
11
42
2.64
2.15
1.5
1.2
—
—
—
0
0
37
229
1.65
2.12
1.4
3.6
33.38
51.52
mg/l
0.77
32
194
37
229
1.65
2.12
1.4
3.6
49.83
83.73
mg/l
0.67
31
194
73
527
1.43
2.09
3.9
3.4
258.00
250.57
ng/l
0.05
64
482
14
62
2.28
2.08
1.2
1.2
2.50
2.00
u/ml
—
8
20
27
154
1.78
2.06
2.4
2.3
—
—
—
0
0
467
5030
0.81
2.06
5.9
6.0
2.45
2.56
mmol/l
1.88
430
4583
212
2477
0.80
2.05
5.0
5.8
6.39
5.03
ug/l
0.13
189
2187
21
111
1.92
2.02
1.4
1.3
23.56
18.32
e6/l
0.12
16
84
11
44
2.52
2.02
1.2
1.2
—
—
—
0
0
8
26
3.10
2.02
1.0
1.1
—
—
—
0
0
456
4919
0.81
2.01
5.3
5.2
4.37
4.43
mmol/l
0.68
420
4511
10
38
2.65
2.01
1.1
1.3
—
—
—
0
0
23
126
1.85
2.00
1.3
1.2
—
—
—
0
0
13
58
2.26
1.91
2.0
1.6
—
—
—
0
0
5
12
4.19
1.82
1.2
1.0
—
—
—
0
0
19
101
1.90
1.82
1.5
1.3
73.36
241.91
miu/ml
—
9
40
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
30
2.68
1.72
1.0
1.2
—
—
—
0
0
8
30
2.68
1.72
5.6
4.0
114.63
137.87
nmol/l
—
8
30
133
1086
1.27
1.72
4.2
3.3
1.19
1.10
e6/l
0.08
80
611
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
5
13
3.86
1.71
3.0
1.7
104.20
100.38
%
—
5
13
15
75
2.02
1.70
1.8
2.7
55.29
19.98
mg/l
—
7
30
382
3481
1.20
1.70
7.6
5.2
6.64
6.81
mmol/l
0.94
365
3318
288
2563
1.20
1.65
3.9
3.0
—
—
estimate
—
0
0
10
41
2.46
1.65
1.5
1.1
1.39
1.16
promille
—
10
32
5
14
3.59
1.62
1.0
1.1
—
—
—
0
0
437
4687
0.84
1.60
4.4
4.4
1.20
1.27
mmol/l
1.41
395
4227
517
5462
0.83
1.60
42.5
24.9
86.65
85.42
umol/l
0.17
512
5371
125
1027
1.26
1.54
4.4
3.4
1.65
1.57
e6/l
0.07
70
550
5
15
3.35
1.52
1.0
1.3
—
—
—
0
0
273
2434
1.19
1.51
2.7
2.4
78.19
77.21
nmol/l
0.19
246
2157
35
235
1.51
1.49
1.9
2.5
10.87
10.98
g/l
0.05
25
206
26
163
1.62
1.48
1.3
1.3
—
—
—
0
0
274
2448
1.19
1.47
5.4
4.2
40.81
43.79
ng/l
0.23
207
1894
310
2800
1.18
1.46
3.4
2.8
—
—
—
0
0
11
52
2.13
1.45
1.5
1.2
—
—
—
0
0
13
66
1.99
1.44
1.2
1.2
2.63
7.29
u/ml
—
8
28
5
16
3.14
1.44
1.0
3.2
3.40
5.31
ug/l
—
5
16
120
1440
0.80
1.43
3.4
3.3
0.73
0.83
ug/l
0.77
81
982
9
39
2.32
1.43
1.9
1.5
—
—
—
0
0
365
3354
1.17
1.38
5.7
3.4
60.52
53.68
u/l
0.64
347
3134
6
23
2.62
1.37
21.8
16.7
726.17
926.61
nmol/l
—
6
23
458
4858
0.85
1.33
6.6
6.9
40.09
40.14
mmol/mol
0.03
424
4483
465
4925
0.85
1.32
5.6
5.4
5.93
6.07
mmol/l
1.32
427
4438
6
24
2.51
1.30
1.0
1.0
—
—
—
0
0
39
279
1.42
1.25
1.2
1.2
129.28
134.23
u/ml
0.02
15
104
6
25
2.41
1.24
2.0
3.0
91.33
104.52
%
—
6
25
26
383
0.67
1.23
1.8
2.1
3.05
3.58
ratio
1.30
19
316
11
57
1.94
1.17
4.5
3.4
7.45
6.36
nmol/l
0.09
11
57
24
158
1.54
1.16
1.7
1.4
315.48
291.32
ug/g
0.19
16
91
173
1963
0.85
1.15
4.4
4.2
12.46
9.78
mg/mmol
0.34
112
1273
316
2902
1.15
1.15
4.7
4.2
0.00
0.00
estimate
-0.00
53
658
11
58
1.91
1.12
1.1
1.1
—
0.75
—
0
6
7
31
2.27
1.10
1.6
3.2
1.00
0.68
%
—
7
31
320
2951
1.15
1.08
4.8
4.3
0.00
0.48
estimate
0.51
52
632
59
464
1.29
1.07
4.6
4.0
98.70
91.46
ng/l
0.21
50
405
199
1777
1.16
1.04
4.7
3.6
0.61
0.50
e6/l
0.29
159
1358
9
46
1.97
1.04
1.3
1.2
86.78
95.60
%
—
9
40
9
46
1.97
1.04
1.0
1.1
—
—
—
0
0
5
22
2.28
1.03
1.0
1.3
—
—
—
0
0
514
5359
0.87
1.00
22.0
12.5
24.20
25.70
u/l
1.47
506
5179
20
132
1.53
0.98
2.5
2.2
—
—
—
0
0
16
100
1.61
0.97
1.3
1.2
355.11
269.63
u/ml
—
9
49
316
2929
1.14
0.97
4.8
4.3
0.00
2.41
estimate
0.50
57
674
7
37
1.90
0.94
7.7
3.3
19.71
61.99
u/ml
—
7
37
41
314
1.32
0.92
2.5
1.9
—
—
—
0
0
226
2057
1.14
0.91
4.9
3.7
37.22
111.14
e6/l
1.51
187
1618
31
228
1.38
0.90
1.5
1.3
—
—
—
0
0
67
552
1.23
0.86
2.6
2.6
6.64
7.08
ug/l
0.09
51
482
204
1850
1.14
0.86
2.1
1.8
19.26
20.06
nmol/l
0.36
178
1563
514
5337
0.88
0.85
39.0
23.1
4.00
4.01
mmol/l
0.34
507
5212
67
555
1.23
0.83
3.5
2.5
34.36
35.30
u/l
0.08
61
458
6
32
1.88
0.82
1.3
2.5
—
—
—
0
0
451
4712
0.89
0.80
5.6
5.1
1.84
1.99
mu/l
1.86
408
4255
0
24
0.00
0.79
0.0
1.1
—
15.67
—
0
10
6
33
1.82
0.79
1.3
1.1
236.33
251.41
mg/l
—
6
27
163
1465
1.14
0.79
3.7
2.8
4.01
4.69
e6/l
0.50
150
1339
19
269
0.70
0.79
1.7
1.8
2.65
3.50
mmol/l
3.11
11
203
8
48
1.67
0.79
1.0
1.1
—
—
—
0
0
21
148
1.43
0.78
1.8
1.6
8150.00
14498.12
e6/l
0.77
16
109
12
74
1.63
0.78
1.1
1.0
—
—
—
0
0
515
5336
0.89
0.78
38.6
22.8
138.85
139.61
mmol/l
6.77
509
5218
10
59
1.70
0.76
1.3
1.2
112.60
110.76
%
—
10
54
5
24
2.09
0.74
1.2
1.1
—
—
—
0
0
44
353
1.26
0.73
2.6
2.0
—
—
—
0
0
5
25
2.01
0.72
1.6
1.8
38.00
54.46
ug/l
—
5
25
80
686
1.19
0.71
1.5
1.5
—
—
—
0
0
5
27
1.86
0.68
1.8
1.6
41.38
40.13
g/l
—
5
27
7
43
1.63
0.67
1.0
1.2
76.14
95.35
pmol/l
—
7
43
393
3748
1.10
0.66
6.7
5.1
6219.00
2455.44
e6/l
—
10
72
5
28
1.79
0.66
1.0
1.3
—
—
—
0
0
5
28
1.79
0.66
1.0
1.3
—
—
—
0
0
53
441
1.22
0.66
3.0
3.1
61.15
60.73
ml/min/173m2
0.02
27
191
11
70
1.58
0.65
1.2
1.5
—
—
—
0
0
11
70
1.58
0.65
1.2
1.5
—
—
—
0
0
188
2037
0.90
0.63
2.1
2.0
1.23
1.31
mmol/l
1.04
166
1674
11
71
1.56
0.62
1.2
1.5
—
—
—
0
0
475
4915
0.91
0.61
31.7
18.7
77.38
75.31
ml/min/173m2
1.04
445
4596
8
50
1.61
0.61
1.0
1.1
—
—
—
0
0
11
72
1.54
0.59
1.6
1.7
—
—
—
0
0
11
72
1.54
0.59
1.2
1.4
—
—
—
0
0
369
3858
0.91
0.59
4.6
4.0
15.19
14.96
pmol/l
0.93
334
3458
21
158
1.34
0.57
1.7
1.3
—
—
—
0
0
142
1294
1.12
0.57
4.8
4.4
1.02
1.02
kg/l
0.34
96
886
11
73
1.51
0.56
1.2
1.4
—
—
—
0
0
75
658
1.16
0.54
9.5
8.2
—
—
—
0
0
11
74
1.49
0.53
3.0
1.9
85.44
89.73
%
0.67
11
74
11
74
1.49
0.53
1.2
1.4
—
—
—
0
0
182
1956
0.91
0.52
3.7
3.4
6.63
7.56
mmol/l
2.33
155
1634
17
126
1.36
0.52
1.3
1.3
—
—
—
0
0
6
41
1.47
0.50
1.3
1.9
79.67
106.11
ng/l
—
6
41
141
1299
1.11
0.48
1.7
1.8
471.61
5342521.73
pmol/l
0.50
119
1067
7
47
1.49
0.47
1.3
1.4
—
38.00
—
0
5
23
182
1.27
0.47
4.3
2.5
7.23
7.83
kpa
1.30
23
177
19
147
1.30
0.45
2.2
1.5
—
—
—
0
0
5
32
1.57
0.42
1.0
1.4
—
—
—
0
0
280
2676
1.07
0.41
2.7
2.3
87.16
93.85
pmol/l
1.83
174
1448
137
1272
1.09
0.41
3.6
3.2
2.46
2.46
mmol/l
0.21
118
1133
24
195
1.24
0.41
4.2
2.9
1.46
1.71
mg/l
0.97
24
171
0
17
0.00
0.40
0.0
3.5
—
5.03
—
0
17
0
17
0.00
0.40
0.0
3.5
—
10.01
—
0
17
16
123
1.31
0.40
1.4
1.6
736.13
287.36
mu/l
0.74
16
114
7
105
0.66
0.39
1.0
1.1
1.61
1.54
g/l
—
7
105
5
35
1.43
0.39
2.6
2.4
—
—
—
0
0
9
66
1.37
0.38
1.3
1.1
—
—
—
0
0
5
36
1.39
0.38
1.0
1.3
—
—
—
0
0
12
89
1.35
0.38
1.2
1.4
—
—
—
0
0
8
113
0.70
0.37
1.1
1.2
0.79
0.88
g/l
—
8
113
21
171
1.23
0.36
4.3
3.7
2.93
1.93
index
0.20
13
95
13
167
0.77
0.34
1.3
1.9
49.77
42.60
nmol/l
0.52
13
159
11
82
1.35
0.34
5.7
4.7
351.09
339.93
umol/l
0.13
11
72
151
1598
0.93
0.32
4.4
3.7
0.00
0.07
estimate
0.86
47
511
117
1097
1.08
0.29
1.4
1.3
3.95
1.44
u/ml
0.43
23
278
74
680
1.10
0.29
4.9
5.0
34.28
32.32
%
0.60
50
428
511
5194
0.95
0.26
36.8
19.0
29.15
27.53
mg/l
0.56
469
4409
19
160
1.19
0.25
1.2
1.2
—
—
—
0
0
17
142
1.20
0.25
3.5
4.0
35.30
31.32
mg/l
—
9
105
24
208
1.16
0.24
2.7
2.8
153.94
62.08
u/ml
0.44
24
200
7
95
0.73
0.22
1.4
1.5
—
—
—
0
0
5
41
1.22
0.22
8.4
1.9
—
—
—
0
0
5
41
1.22
0.22
1.0
1.0
211.20
275.19
ng/l
—
5
26
5
41
1.22
0.22
1.0
1.0
19.60
36.81
ng/l
—
5
25
0
11
0.00
0.21
0.0
1.2
—
1.17
—
0
11
0
11
0.00
0.21
0.0
1.9
—
8.23
—
0
11
0
10
0.00
0.21
0.0
9.7
—
10.77
—
0
10
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.0
—
2.33
—
0
6
6
51
1.18
0.19
1.2
1.2
—
—
—
0
0
18
160
1.13
0.14
1.2
1.2
—
—
—
0
0
11
95
1.16
0.11
1.6
1.9
32.45
33.02
pg
0.19
11
95
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
12
107
1.12
0.08
4.4
3.5
12.01
10.04
pmol/l
0.18
12
107
7
66
1.06
0.08
1.0
1.3
—
—
—
0
0
69
668
1.04
0.08
5.0
3.8
—
—
—
0
0
10
90
1.11
0.05
2.0
1.4
—
—
—
0
0
224
2222
1.01
0.03
4.7
4.3
0.05
0.05
estimate
0.03
44
550
168
1664
1.01
0.03
5.3
4.3
0.00
0.01
estimate
0.78
51
584
12
128
0.94
0.02
1.3
1.9
171.17
221.39
pmol/l
0.99
12
119
14
148
0.94
0.02
1.5
2.5
130.50
101.96
ug/min
—
6
91
46
469
0.98
0.02
1.5
1.4
—
—
—
0
0
16
165
0.97
0.00
4.6
3.4
6.86
7.54
mmol/l
0.58
16
160
22
219
1.00
0.00
1.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
5
54
0.93
0.00
1.4
2.5
1574.60
1069.45
mg
—
5
54
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
0.19
—
0
9
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
30.14
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint AB1_RESP_TUBERCU_CONF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_RESP_TUBERCU_CONF | 2.229 [1.96, 2.54] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.076 |
During the follow-up period (1.1.1998 — 31.12.2019), 994 out of 2033 females with AB1_RESP_TUBERCU_CONF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_RESP_TUBERCU_CONF | 2.551 [2.23, 2.92] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 1865 out of 3273 males with AB1_RESP_TUBERCU_CONF died.
Mortality risk
Mortality risk for people of age
years, who have AB1_RESP_TUBERCU_CONF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.13% | 0.496% |
| 5 | 0.995% | 2.92% |
| 10 | 2.597% | 6.619% |
| 15 | 5.126% | 11.95% |
| 20 | 9.257% | 20.013% |
Relationships between endpoints
↥Index endpoint: AB1_RESP_TUBERCU_CONF – Respiratory tuberculosis, confirmed
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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