osteochondrodysplasia: A term referring to disorders characterized by abnormalities in the development of bones and cartilage.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
331 |
4. Check minimum number of eventsNone |
331 |
5. Include endpointsNone |
331 |
6. Filter based on genotype QC (FinnGen only) |
317 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_DEFORMAT_MUSCULOS_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q6[5-9]|Q7
- Name in latin
- Aliae osteochondrodysplasiae
Similar endpoints
↥List of similar endpoints to
Other osteochondrodysplasias
based on the number of shared cases.
Similar with more cases:
- Congenital malformations and deformations of the musculoskeletal system
- Congenital malformations and deformations of the musculoskeletal system
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities
- Any operation in hilmo
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: unknown.
No upset table: unknown.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2943 | 1494 | 1438 |
| Only index persons | 2617 | 1336 | 1281 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 20.01 | 23.59 | 15.99 |
| Only index persons | 22.24 | 27.33 | 16.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 317 | 196 | 121 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.06 |
| Median age at first event (years) | 37.93 | 38.24 | 37.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 331
- Matched controls
- 3310
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q78.00
ICD-10 Finland
Congenital osteogenesis imperfecta
+∞
95.6
87
*
Q78.6
ICD-10 Finland
Multiple congenital exostoses
1064.3
86.7
81
*
Z31.5
ICD-10 Finland
Genetic counselling
9.0
58.5
84
121
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
20.1
55.1
44
25
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
9.7
53.6
70
89
Q78.9
ICD-10 Finland
Osteochondrodysplasia, unspecified
+∞
50.3
47
*
Q78.48
ICD-10 Finland
Enchondromatosis
+∞
39.4
37
*
NF3AA
NOMESCO Finland
Femur X-ray examination
14.9
37.9
35
26
Q78.1
ICD-10 Finland
Polyostotic fibrous dysplasia
+∞
32.9
31
*
NG4AA
NOMESCO Finland
Lower leg X-ray examination
8.8
32.3
43
55
NE1AA
NOMESCO Finland
Pelvis X-ray examination
7.3
31.8
51
81
Q78.2
ICD-10 Finland
Osteopetrosis
+∞
29.6
28
*
M05BA04
ATC
alendronic acid; oral
7.1
29.1
47
75
Q78.08
ICD-10 Finland
Osteogenesis imperfecta tarda
+∞
25.3
24
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.8
24.2
62
152
7564A
ICD-9 Finland
Other congenital musculoskeletal anomalies, Chondrodystrophy
+∞
23.2
22
*
Q78.88
ICD-10 Finland
Other specified osteochondrodysplasias
+∞
21.1
20
*
75650
ICD-8 Finland
Other congenital anomalies of musculoskeletal system, Chondrodystrophy
+∞
20.0
19
*
L28
ICPC
Limited function/disability (L)
3.7
19.4
71
225
R5110, ,
SPAT
6.2
19.4
35
62
S72.3
ICD-10 Finland
Fracture of shaft of femur
46.9
18.5
22
5
R4110
NOMESCO Finland
Physiotherapy
2.9
18.4
126
580
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
17.9
18.2
28
17
ZXA05
NOMESCO Finland
Left side
3.1
18.2
96
382
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
28.6
18.1
24
9
TNX34
NOMESCO Finland
Major custom molded cast, unspecified region
20.0
17.6
26
14
NF1AA
NOMESCO Finland
Hip X-ray examination
4.8
17.1
41
94
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
5.5
17.1
35
70
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
16.9
119
552
Q78.40
ICD-10 Finland
Enchondromatosis
+∞
16.8
16
*
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
7.4
16.8
25
36
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.2
16.7
49
132
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.8
16.7
124
591
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
5.0
15.6
35
76
M81.9
ICD-10 Finland
Osteoporosis, unspecified
6.5
14.9
25
41
WX1PA
NOMESCO Finland
Total body mineral density measurement with Dual energy X-ray absorptiometry (DXA)
156.6
14.6
15
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.1
14.3
68
252
ZXE20
NOMESCO Finland
More than three and less than five hours
3.3
14.1
60
208
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.4
14.0
55
181
X59
ICD-10 Finland
Exposure to unspecified factor
2.7
13.8
90
396
D16.1
ICD-10 Finland
Benign neoplasm: Short bones of upper limb
78.5
13.7
15
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
17.1
13.6
21
13
NFJ60
NOMESCO Finland
Internal fixation of fracture of other parts of femur with intramedullary nail
35.7
13.6
17
5
ZXA00
NOMESCO Finland
Right side
2.7
13.6
94
426
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.3
12.7
52
175
5BA08, ,
NOMESCO Finland
72.7
12.7
14
*
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
72.7
12.7
14
*
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
5.7
12.5
24
45
NFU20
NOMESCO Finland
Removal of internal fixation device from femur
15.1
12.4
20
14
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
39.1
12.3
15
*
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
14.1
12.1
20
15
DFF00
NOMESCO Finland
Pure tone audiometry
3.5
12.0
45
143
Z3226
NOMESCO Finland
Physiotherapist
2.6
11.9
86
396
A28
ICPC
Limited function/disability NOS
3.1
11.9
54
194
M79.6
ICD-10 Finland
Pain in limb
2.3
11.8
156
936
EBA15
NOMESCO Finland
Extraction of multiple teeth
5.8
11.8
22
40
S82.2
ICD-10 Finland
Fracture of shaft of tibia
9.8
11.7
23
25
R4120
NOMESCO Finland
Occupational therapy
3.8
11.7
37
105
SPAT1229
SPAT
Assessment of need for aid
4.5
11.5
29
69
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
13.4
11.3
19
15
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
11.0
82
381
NFK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of femur
44.9
11.0
13
*
N02AX02
ATC
tramadol; systemic, rectal
2.2
10.5
141
841
Q78.80
ICD-10 Finland
Osteopoiesis
+∞
10.5
10
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
10.4
137
811
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.9
10.4
55
215
M05BA07
ATC
risedronic acid; oral
10.5
10.2
19
19
9165
FHL
Removal of osteosynthesis material
9.2
9.9
20
23
9102
FHL
Trepanation or removal of the local bone process
20.8
9.9
14
7
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
9.8
101
539
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.4
9.8
37
118
ZX120
NOMESCO Finland
Intravenous
3.2
9.8
42
145
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
11.9
9.7
17
15
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
9.6
130
773
X58
ICD-10 Finland
Exposure to other specified factors
2.5
9.5
70
322
NBR20
NOMESCO Finland
Intralesional or marginal excision of soft tissue tumour of shoulder or upper arm
102.9
9.5
10
*
M05BX04
ATC
denosumab; parenteral
4.7
9.4
22
49
NFK10
NOMESCO Finland
Fenestration or partial or total excision of bone of femur
+∞
9.4
9
*
M25.5
ICD-10 Finland
Pain in joint
2.1
9.3
123
723
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
16.2
9.1
14
9
ZXE00
NOMESCO Finland
One hour or less
2.0
8.9
146
927
SAA04
NOMESCO Finland
Special examination of mouth
3.3
8.8
35
115
Z3229
NOMESCO Finland
Other healthcare associate professional
3.1
8.7
39
138
WX402
NOMESCO Finland
General anaesthesia
2.2
8.6
85
443
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
4.4
8.6
22
53
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.5
8.6
31
96
S18
ICPC
Laceration/cut
2.0
8.5
147
947
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
92.3
8.5
9
*
D16.0
ICD-10 Finland
Benign neoplasm: Scapula and long bones of upper limb
92.3
8.5
9
*
L82
ICPC
Congenital anomaly musculoskeletal
+∞
8.4
8
*
5BA03, ,
NOMESCO Finland
+∞
8.4
8
*
Z3231
NOMESCO Finland
Registered nurse
2.1
8.2
110
644
ZXD35
NOMESCO Finland
Usual procedure
5.0
8.2
18
38
L13
ICPC
Hip symptom/complaint
2.4
8.1
61
283
L95
ICPC
Osteoporosis
6.9
8.0
19
29
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.5
8.0
28
85
E883A
ICD-9 Finland
Fall into hole or other opening in surface
3.9
7.8
23
62
NFB60
NOMESCO Finland
Demanding prosthetic replacement of hip
46.1
7.7
9
*
WX002
NOMESCO Finland
Sedation and analgesia
2.3
7.7
65
316
S22.4
ICD-10 Finland
Multiple fractures of ribs
12.2
7.6
13
11
Z2221
NOMESCO Finland
Medical doctor
2.0
7.6
106
627
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.4
7.6
28
88
NFK99
NOMESCO Finland
Other operation on bone of femur
81.9
7.4
8
*
M85.0
ICD-10 Finland
Fibrous dysplasia (monostotic)
81.9
7.4
8
*
K00.51
ICD-10 Finland
Dentinogenesis imperfecta
81.9
7.4
8
*
7569X
ICD-9 Finland
Other congenital musculoskeletal anomalies, Other and unspecified anomalies of musculoskeletal system
+∞
7.3
7
*
7565A
ICD-9 Finland
Other congenital musculoskeletal anomalies, Osteodystrophies
+∞
7.3
7
*
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.1
7.2
30
102
WX110
NOMESCO Finland
Infiltration anesthesia
2.0
7.0
250
1999
NC2AA
NOMESCO Finland
Forearm X-ray examination
6.6
7.0
17
27
J30.4
ICD-10 Finland
Allergic rhinitis, unspecified
3.9
7.0
21
57
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.1
7.0
19
48
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
14.2
6.9
11
8
NCU20
NOMESCO Finland
Removal of internal fixation device from elbow or forearm
8.5
6.9
14
17
SPAT1215
SPAT
Assessment of need for medical rehabilitation
4.4
6.8
17
40
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
3.6
6.8
23
68
B01AB05
ATC
enoxaparin; parenteral
2.0
6.8
94
552
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
40.9
6.8
8
*
NB4AA
NOMESCO Finland
Scapula X-ray examination
40.9
6.8
8
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
7.4
6.8
15
21
W00
ICD-10 Finland
Fall on same level involving ice and snow
2.5
6.8
46
203
M01AE03
ATC
ketoprofen; systemic, rectal
1.9
6.7
108
667
NGU20
NOMESCO Finland
Removal of internal fixation device from knee or lower leg
6.1
6.7
17
29
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
3.6
6.7
22
64
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
8.1
6.7
14
18
RK110, ,
NOMESCO Finland
12.6
6.6
11
9
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.0
6.6
30
107
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
6.6
83
472
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
6.4
70
377
Z2446
NOMESCO Finland
Social worker
2.6
6.4
37
151
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
7.3
6.3
14
20
WX212
NOMESCO Finland
Femoral plexus blockade
7.3
6.3
14
20
2137A
ICD-9 Finland
Benign neoplasm of bone and articular cartilage, Long bones of lower limb
+∞
6.3
6
*
75665
ICD-8 Finland
Other congenital anomalies of musculoskeletal system, Exostosis cartilaginea multiplex
+∞
6.3
6
*
3870A
ICD-9 Finland
Otosclerosis involving oval window, nonobliterative
27.2
6.3
8
*
NGJ60
NOMESCO Finland
Internal fixation of fracture of knee or lower leg using intramedullary nail, other or unspecified
10.3
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
55
8
82.01
49.85
4.2
2.0
106.84
54.45
ug/l
—
55
8
201
1063
3.27
24.44
5.5
2.5
78.40
75.10
nmol/l
1.01
196
969
196
1059
3.09
22.27
10.1
7.1
1.23
1.22
mmol/l
0.47
190
984
206
1153
3.08
21.81
10.4
7.5
1.22
1.22
mmol/l
0.37
183
992
137
727
2.51
14.39
4.8
3.3
7.19
8.07
mmol/l
1.05
126
639
256
1914
2.49
11.10
9.1
6.8
89.93
81.96
u/l
1.37
251
1800
125
759
2.04
8.53
3.8
3.0
2.36
2.36
mmol/l
0.07
115
686
49
211
2.55
7.58
10.9
9.6
26.04
24.99
mmol/l
1.36
49
211
206
1563
1.84
6.59
10.3
9.8
3.80
3.92
e9/l
0.40
170
1369
29
105
2.93
6.23
2.0
1.6
—
—
—
0
0
180
1345
1.74
5.74
7.4
6.5
29.35
30.56
%
0.77
168
1288
191
1452
1.75
5.73
5.0
5.1
6.20
6.48
mmol/l
1.26
182
1329
45
215
2.27
5.52
7.1
10.3
14.20
12.86
kpa
0.75
45
207
45
215
2.27
5.52
7.0
10.4
1.37
1.32
mmol/l
0.03
36
177
45
215
2.27
5.52
7.1
10.3
5.16
5.26
kpa
0.29
45
207
176
1331
1.69
5.18
7.3
6.4
55.66
55.02
%
0.29
164
1270
95
606
1.80
5.17
2.6
2.3
—
—
—
0
0
15
34
4.57
4.81
1.1
1.2
—
—
—
0
0
59
336
1.92
4.55
2.3
1.8
—
—
—
0
0
14
33
4.38
4.37
1.4
1.1
—
—
—
0
0
45
238
2.03
4.28
2.2
1.7
—
—
—
0
0
39
196
2.12
4.24
6.4
9.3
1.31
1.36
mmol/l
0.14
39
191
44
232
2.03
4.22
2.1
1.6
—
—
—
0
0
30
136
2.33
4.17
1.6
1.5
12.91
8.72
u/l
0.55
21
100
47
255
1.98
4.16
5.1
6.7
1.42
2.04
mmol/l
0.65
41
194
34
167
2.15
3.92
1.8
1.5
22.73
20.57
iu/l
0.14
27
132
155
1192
1.56
3.89
2.9
2.6
—
—
—
0
0
118
853
1.60
3.86
2.0
1.8
102.16
98.23
pmol/l
0.35
58
418
119
866
1.58
3.77
4.5
3.3
—
—
—
0
0
98
682
1.62
3.73
4.7
3.3
0.17
0.30
e6/l
0.99
72
517
227
1931
1.56
3.43
4.9
4.0
11.73
9.54
mm/h
1.70
216
1797
0
86
0.00
3.37
0.0
1.3
—
—
—
0
0
127
959
1.53
3.33
5.3
5.3
36.13
37.03
g/l
1.05
117
907
276
2475
1.69
3.18
5.3
4.5
1.72
2.33
mu/l
0.70
260
2300
125
952
1.50
3.11
13.6
9.6
1.11
1.16
inr
0.38
43
290
61
395
1.67
3.04
4.1
3.1
3.22
2.10
e6/l
0.52
29
222
6
9
6.76
2.88
1.2
2.2
148.50
140.89
%
—
6
9
11
33
3.41
2.84
1.3
1.2
—
—
—
0
0
8
18
4.53
2.81
1.5
1.4
—
—
—
0
0
62
413
1.62
2.77
4.1
3.0
1.14
0.82
e6/l
0.43
30
238
44
268
1.74
2.74
6.9
7.9
104.73
104.54
mmol/l
0.10
44
268
16
67
2.46
2.67
2.6
1.1
—
—
—
0
0
16
67
2.46
2.67
2.6
1.1
—
—
—
0
0
16
67
2.46
2.67
1.9
2.3
—
—
—
0
0
8
20
4.07
2.58
3.6
5.5
0.37
2.47
ug/l
—
8
20
155
1265
1.42
2.57
6.6
6.2
11.03
11.44
umol/l
0.10
145
1198
31
175
1.85
2.48
2.6
3.4
4.64
4.76
pmol/l
0.30
26
152
53
351
1.61
2.42
2.1
2.1
14.15
14.66
umol/l
0.17
46
324
9
28
3.27
2.32
1.1
1.2
—
—
—
0
0
10
34
3.00
2.30
1.5
1.5
—
—
—
0
0
263
2389
1.49
2.26
15.1
10.0
93.12
89.56
ml/min/173m2
1.61
233
1891
237
2116
1.42
2.19
4.8
3.9
14.41
14.57
pmol/l
0.52
222
1941
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
6
14
4.34
2.16
1.2
1.8
107.33
137.86
%
—
6
14
54
373
1.54
2.07
2.6
2.6
2.45
2.43
mmol/l
0.65
48
328
33
202
1.70
2.05
3.2
3.0
—
—
—
0
0
49
332
1.56
2.04
1.4
1.6
1174.67
1188.79
nmol/l
0.04
39
251
20
105
1.96
2.00
3.2
5.8
1.23
1.49
%
0.58
20
105
12
51
2.40
1.97
2.2
3.7
6.01
4.93
kpa
1.15
12
51
10
39
2.61
1.96
1.4
1.3
2315.20
9275.73
e6/l
—
5
26
32
198
1.68
1.92
12.3
5.1
1.36
1.14
mmol/l
0.09
25
137
19
100
1.95
1.89
3.3
5.9
0.43
0.65
%
2.73
19
100
58
415
1.48
1.89
1.6
1.6
175000462.63
460.01
pmol/l
0.49
52
356
46
316
1.53
1.82
2.0
2.2
2.50
2.46
g/l
0.16
41
292
18
95
1.95
1.79
2.2
5.5
161.78
170.67
%
0.21
18
95
43
292
1.54
1.79
2.1
2.2
23.12
24.03
%
0.13
38
255
26
155
1.74
1.78
1.4
2.5
2075.59
4131.28
u/l
—
7
66
22
125
1.81
1.77
15.0
5.8
9.90
9.43
kpa
0.72
22
120
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
12
54
2.27
1.76
3.3
6.9
0.42
0.36
u/ml
—
7
31
289
2717
1.50
1.68
16.5
11.5
22.24
20.63
mg/l
0.39
234
2041
78
605
1.38
1.64
3.0
2.3
2.67
3.00
mg/l
0.84
66
517
68
517
1.40
1.61
2.8
3.3
2396.31
815.31
ng/l
1.08
53
433
7
26
2.73
1.59
1.3
1.2
—
—
—
0
0
6
20
3.04
1.59
1.2
1.1
—
—
—
0
0
11
52
2.15
1.46
1.7
2.3
—
—
—
0
0
7
28
2.53
1.46
1.6
4.4
—
—
—
0
0
5
16
3.16
1.44
2.8
3.4
—
—
—
0
0
5
16
3.16
1.44
1.0
2.1
—
—
—
0
0
5
16
3.16
1.44
1.4
1.0
89.20
89.50
%
—
5
16
320
3099
1.98
1.44
24.3
17.1
40.37
40.53
%
0.23
311
2952
12
60
2.04
1.40
1.8
2.0
232.86
136.84
ug/l
0.31
12
55
14
75
1.90
1.36
1.4
2.1
—
—
—
0
0
13
68
1.95
1.35
1.4
1.4
386.43
319.10
ug/g
—
7
41
74
588
1.33
1.33
3.2
3.7
7.39
10.36
mg/mmol
0.38
45
374
144
1251
1.27
1.32
2.9
2.8
95.21
97.03
ug/l
0.04
133
1166
320
3106
1.91
1.31
24.4
17.0
134.96
136.39
g/l
0.99
320
3071
5
18
2.80
1.29
3.0
3.2
—
—
—
0
0
5
18
2.80
1.29
1.0
1.1
—
—
—
0
0
146
1274
1.26
1.28
4.0
3.3
0.00
0.00
estimate
0.50
34
256
59
456
1.36
1.27
1.3
1.3
11.32
31.77
iu/ml
3.46
15
142
299
2860
1.47
1.27
11.9
9.2
27.64
27.02
u/l
0.26
294
2781
146
1276
1.26
1.26
5.5
4.6
0.00
0.00
estimate
-0.00
36
247
147
1289
1.25
1.22
4.0
3.4
0.00
0.00
estimate
-0.00
35
233
8
37
2.19
1.22
1.3
1.6
—
—
—
0
0
24
158
1.56
1.18
2.3
1.5
—
—
—
0
0
5
20
2.52
1.15
1.2
1.4
—
—
—
0
0
14
80
1.78
1.14
2.0
2.3
—
—
—
0
0
31
218
1.47
1.14
4.1
8.0
8.41
6.83
mmol/l
0.56
31
211
71
575
1.30
1.12
2.2
3.1
334.02
4123.78
umol/l
1.53
66
514
19
120
1.62
1.11
8.1
10.7
24.85
24.77
mmol/l
0.03
19
115
62
496
1.31
1.07
1.7
1.4
24.36
21.45
nmol/l
0.78
57
417
7
33
2.14
1.06
1.1
1.7
—
—
—
0
0
11
61
1.83
0.99
1.5
1.4
—
—
—
0
0
69
567
1.27
0.98
1.7
2.3
2.26
1.04
mg/l
0.51
54
432
0
29
0.00
0.98
0.0
1.8
—
—
—
0
0
79
664
1.25
0.93
4.2
3.6
0.00
0.00
estimate
0.50
34
245
19
127
1.53
0.90
1.7
1.3
—
—
—
0
0
104
906
1.22
0.88
3.1
3.4
32.65
30.58
u/l
0.25
97
873
49
393
1.29
0.85
3.4
3.2
47.59
228.89
ng/l
2.00
41
260
6
34
1.78
0.76
2.0
1.6
—
—
—
0
0
10
59
1.72
0.76
1.4
1.2
1.40
3.46
ug/l
—
10
52
14
91
1.56
0.76
1.4
2.3
—
—
—
0
0
6
107
0.55
0.74
1.7
1.5
—
—
—
0
0
26
195
1.36
0.72
4.0
4.9
5.21
6.45
ug/l
0.15
17
158
9
57
1.59
0.71
1.2
3.0
3.92
3.64
mmol/l
—
9
52
9
59
1.54
0.69
1.8
2.3
—
—
—
0
0
7
42
1.68
0.69
1.1
1.1
—
—
—
0
0
5
27
1.86
0.68
1.6
1.6
—
—
—
0
0
7
43
1.64
0.67
5.1
2.8
144.14
37.20
u/ml
—
7
43
198
1858
1.16
0.66
3.1
3.2
40.95
41.31
u/l
0.02
185
1780
237
2262
1.17
0.61
5.0
4.9
38.29
38.80
mmol/mol
0.39
227
2142
21
157
1.36
0.60
2.2
1.4
268.24
314.52
mu/l
0.57
21
142
0
20
0.00
0.60
0.0
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
1.6
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
8
52
1.55
0.60
2.0
1.7
—
—
—
0
0
6
35
1.73
0.58
2.0
1.5
—
—
—
0
0
6
35
1.73
0.58
2.0
1.5
—
—
—
0
0
6
35
1.73
0.58
2.0
1.5
—
—
—
0
0
6
35
1.73
0.58
2.0
1.5
—
—
—
0
0
38
313
1.24
0.56
1.7
3.9
9.51
7.47
umol/l
0.29
32
267
10
65
1.56
0.56
1.7
1.2
—
—
—
0
0
6
38
1.59
0.54
1.2
1.1
—
—
—
0
0
52
446
1.20
0.53
1.3
1.3
4.45
7.08
u/ml
0.51
16
179
23
291
0.77
0.52
1.7
1.6
—
—
—
0
0
14
189
0.73
0.49
1.3
1.2
—
—
—
0
0
12
166
0.71
0.49
1.4
1.4
—
—
—
0
0
7
49
1.44
0.46
1.1
1.2
—
—
—
0
0
10
140
0.71
0.44
2.0
1.8
—
—
—
0
0
6
91
0.65
0.43
1.3
1.4
—
—
—
0
0
11
149
0.73
0.41
1.5
1.5
—
—
—
0
0
5
35
1.43
0.39
2.2
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
13
98
1.34
0.38
1.2
1.1
—
2.11
—
0
16
8
114
0.69
0.37
1.4
1.6
—
—
—
0
0
9
69
1.31
0.37
1.9
2.0
2.08
5.04
ug/l
—
9
63
6
43
1.40
0.35
1.3
1.1
—
—
—
0
0
226
2187
1.11
0.34
3.4
3.6
—
—
—
0
0
20
242
0.82
0.34
1.6
1.5
—
—
—
0
0
248
2542
0.90
0.32
4.7
4.3
2.90
2.85
mmol/l
0.38
233
2380
7
96
0.72
0.31
1.0
1.4
—
—
—
0
0
246
2520
0.91
0.30
4.1
4.0
4.78
4.74
mmol/l
0.29
232
2371
11
141
0.77
0.30
1.4
1.4
—
—
—
0
0
11
141
0.77
0.30
1.4
1.4
—
—
—
0
0
11
140
0.78
0.28
1.4
1.4
—
—
—
0
0
11
140
0.78
0.28
1.4
1.4
—
—
—
0
0
12
94
1.29
0.28
1.7
1.6
—
—
—
0
0
8
64
1.26
0.27
2.1
1.8
—
—
—
0
0
70
755
0.91
0.27
1.8
1.7
—
—
—
0
0
87
814
1.09
0.27
3.2
3.1
88.64
25.72
ng/l
0.76
49
474
8
66
1.22
0.27
2.1
1.7
—
—
—
0
0
27
308
0.87
0.26
2.2
1.8
—
—
—
0
0
14
114
1.24
0.25
1.6
1.3
—
—
—
0
0
72
671
1.09
0.24
1.8
1.7
1.45
1.41
mmol/l
0.12
65
581
83
781
1.08
0.23
2.6
2.4
57.38
56.62
u/l
0.05
71
730
5
40
1.25
0.22
1.6
1.6
—
—
—
0
0
11
135
0.81
0.22
3.5
1.9
—
—
—
0
0
248
2432
1.08
0.21
4.2
3.8
5.85
5.79
mmol/l
0.25
234
2254
0
11
0.00
0.21
0.0
1.0
—
2.61
—
0
6
0
11
0.00
0.21
0.0
2.8
—
—
—
0
0
0
11
0.00
0.21
0.0
2.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
8
101
0.79
0.21
1.1
1.1
—
—
—
0
0
8
102
0.78
0.21
1.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
0.06
—
0
6
0
12
0.00
0.21
0.0
1.1
—
0.44
—
0
6
21
240
0.87
0.21
2.1
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
6
48
1.25
0.20
3.3
3.8
56.83
54.42
%
—
6
48
6
50
1.20
0.20
1.8
1.1
—
—
—
0
0
246
2502
0.93
0.18
4.0
3.9
1.41
1.46
mmol/l
1.43
232
2346
52
485
1.09
0.18
4.7
4.1
1.78
2.43
ug/l
0.39
46
437
103
990
1.06
0.16
3.9
3.3
—
—
—
0
0
10
83
1.21
0.15
1.4
1.7
252.60
188.33
u/ml
—
5
45
21
188
1.12
0.15
1.0
1.0
—
—
—
0
0
37
398
0.92
0.14
4.2
3.7
25.04
20.87
%
0.59
11
164
43
403
1.08
0.14
1.4
1.8
1.38
1.39
%
0.04
37
359
8
100
0.80
0.14
1.1
1.1
—
—
—
0
0
12
104
1.16
0.12
1.3
1.5
1.16
1.21
g/l
0.29
12
99
23
249
0.92
0.10
6.8
6.6
—
—
—
0
0
46
483
0.94
0.10
1.7
1.5
—
—
—
0
0
10
87
1.15
0.09
1.3
1.6
—
—
—
0
0
6
54
1.11
0.09
1.2
1.1
—
—
—
0
0
5
60
0.83
0.08
1.0
1.2
—
—
—
0
0
7
84
0.83
0.07
1.3
1.5
—
—
—
0
0
20
187
1.07
0.06
2.2
2.4
55.62
70.70
ml/min/173m2
—
8
76
30
293
1.03
0.01
3.6
2.8
0.83
0.68
ug/l
0.26
16
174
78
786
0.99
0.00
1.3
1.4
0.65
1.60
u/ml
0.93
17
187
48
478
1.00
0.00
1.8
2.0
—
—
—
0
0
12
121
0.99
0.00
1.3
1.4
276.00
275.49
miu/ml
—
6
67
53
532
1.00
0.00
1.8
2.1
—
—
—
0
0
18
179
1.01
0.00
1.2
1.2
—
17.04
—
0
8
10
97
1.03
0.00
2.8
4.0
72.53
49.18
%
—
10
97
27
267
1.01
0.00
2.4
3.9
30.05
31.21
%
0.32
19
190
241
2407
1.00
0.00
3.6
3.6
1.35
1.30
mmol/l
0.45
225
2246
24
235
1.02
0.00
1.3
1.3
155.99
184.38
iu/ml
—
7
89
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
25.08
—
0
8
6
60
1.00
0.00
1.2
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.3
—
26.86
—
0
7
0
5
0.00
-0.00
0.0
5.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
82
0.98
-0.00
1.4
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
90
1.00
-0.00
1.1
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.2
—
—
—
0
0
6
64
0.94
-0.00
4.3
2.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_OSTEOCHONDROD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_OSTEOCHONDROD | 1.735 [1.24, 2.42] | 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 1266 females with Q17_OTHER_OSTEOCHONDROD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_OSTEOCHONDROD | 1.75 [1.36, 2.26] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 1206 males with Q17_OTHER_OSTEOCHONDROD died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_OSTEOCHONDROD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.14% | 0.289% |
| 5 | 0.742% | 1.79% |
| 10 | 2.147% | 4.824% |
| 15 | 3.782% | 9.297% |
| 20 | 6.659% | 15.819% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_OSTEOCHONDROD – Other osteochondrodysplasias
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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