osteochondrodysplasia: A term referring to disorders characterized by abnormalities in the development of bones and cartilage.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
353 |
4. Check minimum number of eventsNone |
353 |
5. Include endpointsNone |
353 |
6. Filter based on genotype QC (FinnGen only) |
328 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_DEFORMAT_MUSCULOS_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q6[5-9]|Q7
- Name in latin
- Aliae osteochondrodysplasiae
Similar endpoints
↥List of similar endpoints to
Other osteochondrodysplasias
based on the number of shared cases.
Similar with more cases:
- Congenital malformations and deformations of the musculoskeletal system
- Congenital malformations and deformations of the musculoskeletal system, including avohilmo
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities, including avohilmo
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2943 | 1494 | 1438 |
| Only index persons | 2617 | 1336 | 1281 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 20.01 | 23.59 | 15.99 |
| Only index persons | 22.24 | 27.33 | 16.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 328 | 203 | 125 |
| Unadjusted period prevalence (%) | 0.07 | 0.07 | 0.06 |
| Median age at first event (years) | 38.78 | 39.35 | 37.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 340
- Matched controls
- 3400
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q78.00
ICD-10 Finland
Congenital osteogenesis imperfecta
+∞
95.4
87
*
Q78.6
ICD-10 Finland
Multiple congenital exostoses
1107.5
90.0
84
*
Z31.5
ICD-10 Finland
Genetic counselling
8.3
55.6
85
131
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
17.7
53.0
45
29
Q78.9
ICD-10 Finland
Osteochondrodysplasia, unspecified
+∞
52.5
49
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.5
49.5
72
104
Q78.48
ICD-10 Finland
Enchondromatosis
+∞
40.4
38
*
NF3AA
NOMESCO Finland
Femur X-ray examination
14.3
38.0
36
28
NG4AA
NOMESCO Finland
Lower leg X-ray examination
8.6
34.4
47
62
Q78.1
ICD-10 Finland
Polyostotic fibrous dysplasia
+∞
32.8
31
*
Q78.2
ICD-10 Finland
Osteopetrosis
+∞
32.8
31
*
NE1AA
NOMESCO Finland
Pelvis X-ray examination
6.1
26.8
51
96
M05BA04
ATC
alendronic acid; oral
6.3
26.7
49
89
Q78.08
ICD-10 Finland
Osteogenesis imperfecta tarda
+∞
25.3
24
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.6
24.5
66
168
7564A
ICD-9 Finland
Other congenital musculoskeletal anomalies, Chondrodystrophy
+∞
23.2
22
*
M81.9
ICD-10 Finland
Osteoporosis, unspecified
7.7
22.5
33
47
L28
ICPC
Limited function/disability (L)
3.7
22.2
86
285
Q78.88
ICD-10 Finland
Other specified osteochondrodysplasias
+∞
21.1
20
*
R5110, ,
SPAT
4.8
20.3
50
118
75650
ICD-8 Finland
Other congenital anomalies of musculoskeletal system, Chondrodystrophy
+∞
20.0
19
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
18.5
19.1
29
17
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
29.8
19.0
25
9
NF1AA
NOMESCO Finland
Hip X-ray examination
4.8
19.0
47
111
ZXA05
NOMESCO Finland
Left side
3.1
18.6
100
402
R4110
NOMESCO Finland
Physiotherapy
2.9
18.6
132
619
S72.3
ICD-10 Finland
Fracture of shaft of femur
46.8
18.5
22
5
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.0
17.5
55
156
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
5.3
17.0
36
74
TNX34
NOMESCO Finland
Major custom molded cast, unspecified region
17.5
16.8
26
16
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.7
16.8
128
616
Q78.40
ICD-10 Finland
Enchondromatosis
+∞
16.8
16
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.7
16.3
132
654
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
7.0
16.0
25
38
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
4.9
15.6
36
80
X59
ICD-10 Finland
Exposure to unspecified factor
2.8
14.9
97
428
WX1PA
NOMESCO Finland
Total body mineral density measurement with Dual energy X-ray absorptiometry (DXA)
156.4
14.6
15
*
NFJ60
NOMESCO Finland
Internal fixation of fracture of other parts of femur with intramedullary nail
31.5
14.0
18
6
D16.1
ICD-10 Finland
Benign neoplasm: Short bones of upper limb
55.8
13.9
16
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
3.3
13.9
60
209
ZXA00
NOMESCO Finland
Right side
2.6
13.5
97
447
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.3
13.4
58
202
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
41.9
13.3
16
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.0
13.2
69
269
ZXE20
NOMESCO Finland
More than three and less than five hours
3.1
12.8
60
219
5BA08, ,
NOMESCO Finland
72.6
12.7
14
*
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
72.6
12.7
14
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
13.9
12.6
21
16
S82.2
ICD-10 Finland
Fracture of shaft of tibia
10.2
12.4
24
25
DFF00
NOMESCO Finland
Pure tone audiometry
3.3
12.2
49
163
A28
ICPC
Limited function/disability NOS
3.0
12.1
62
238
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
4.2
12.0
33
84
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.9
11.9
62
240
Z3226
NOMESCO Finland
Physiotherapist
2.6
11.9
88
409
R4120
NOMESCO Finland
Occupational therapy
3.7
11.8
39
114
EBA15
NOMESCO Finland
Extraction of multiple teeth
5.5
11.7
23
44
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
5.3
11.6
24
48
Q78.80
ICD-10 Finland
Osteopoiesis
+∞
11.5
11
*
NFU20
NOMESCO Finland
Removal of internal fixation device from femur
12.4
11.5
20
17
NFK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of femur
36.4
11.3
14
*
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
11.1
10.9
20
19
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
11.8
10.7
19
17
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
10.5
85
409
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
10.5
141
839
SPAT1229
SPAT
Assessment of need for aid
4.1
10.4
29
75
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
11.8
10.2
18
16
N02AX02
ATC
tramadol; systemic, rectal
2.1
10.0
147
902
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
4.5
10.0
25
59
M05BA07
ATC
risedronic acid; oral
9.2
9.9
20
23
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
9.9
135
805
9102
FHL
Trepanation or removal of the local bone process
20.8
9.9
14
7
M79.6
ICD-10 Finland
Pain in limb
2.1
9.8
167
1080
9165
FHL
Removal of osteosynthesis material
8.8
9.7
20
24
NBR20
NOMESCO Finland
Intralesional or marginal excision of soft tissue tumour of shoulder or upper arm
102.8
9.5
10
*
NFK10
NOMESCO Finland
Fenestration or partial or total excision of bone of femur
+∞
9.4
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
9.4
102
555
M05BX04
ATC
denosumab; parenteral
4.1
9.0
25
64
ZXE00
NOMESCO Finland
One hour or less
2.0
8.9
151
966
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
14.5
8.8
14
10
WX402
NOMESCO Finland
General anaesthesia
2.2
8.7
96
523
M25.5
ICD-10 Finland
Pain in joint
2.0
8.6
131
805
SAA04
NOMESCO Finland
Special examination of mouth
3.2
8.6
35
117
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.5
8.6
31
96
Z3231
NOMESCO Finland
Registered nurse
2.1
8.6
114
667
ZX120
NOMESCO Finland
Intravenous
3.0
8.5
41
151
X58
ICD-10 Finland
Exposure to other specified factors
2.3
8.5
75
372
Z3229
NOMESCO Finland
Other healthcare associate professional
3.0
8.5
40
146
M85.0
ICD-10 Finland
Fibrous dysplasia (monostotic)
92.3
8.5
9
*
NFK99
NOMESCO Finland
Other operation on bone of femur
92.3
8.5
9
*
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
92.3
8.5
9
*
D16.0
ICD-10 Finland
Benign neoplasm: Scapula and long bones of upper limb
92.3
8.5
9
*
S18
ICPC
Laceration/cut
2.0
8.4
162
1078
5BA03, ,
NOMESCO Finland
+∞
8.4
8
*
L82
ICPC
Congenital anomaly musculoskeletal
+∞
8.4
8
*
WX002
NOMESCO Finland
Sedation and analgesia
2.4
8.4
68
326
L95
ICPC
Osteoporosis
4.7
8.2
19
42
B01AB05
ATC
enoxaparin; parenteral
2.1
8.1
102
584
ZXD35
NOMESCO Finland
Usual procedure
4.8
8.0
18
39
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.9
7.9
39
146
Z2221
NOMESCO Finland
Medical doctor
2.0
7.8
109
645
NFB60
NOMESCO Finland
Demanding prosthetic replacement of hip
46.1
7.7
9
*
NCU20
NOMESCO Finland
Removal of internal fixation device from elbow or forearm
9.2
7.6
15
17
NGU20
NOMESCO Finland
Removal of internal fixation device from knee or lower leg
6.7
7.5
18
28
K00.51
ICD-10 Finland
Dentinogenesis imperfecta
81.8
7.4
8
*
S22.4
ICD-10 Finland
Multiple fractures of ribs
11.2
7.4
13
12
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
11.2
7.4
13
12
7569X
ICD-9 Finland
Other congenital musculoskeletal anomalies, Other and unspecified anomalies of musculoskeletal system
+∞
7.3
7
*
7565A
ICD-9 Finland
Other congenital musculoskeletal anomalies, Osteodystrophies
+∞
7.3
7
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
7.3
76
403
NB6AA
NOMESCO Finland
Humerus X-ray examination
6.8
7.2
17
26
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.3
7.2
28
91
S72.4
ICD-10 Finland
Fracture of lower end of femur
20.5
7.2
10
5
Z71.8
ICD-10 Finland
Other specified counselling
1.9
7.1
138
908
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
3.6
7.1
24
71
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.2
7.1
28
92
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.9
7.0
21
57
E883A
ICD-9 Finland
Fall into hole or other opening in surface
3.6
7.0
23
67
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.9
6.9
33
121
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
6.9
6.9
16
24
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
40.9
6.8
8
*
NB4AA
NOMESCO Finland
Scapula X-ray examination
40.9
6.8
8
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
7.4
6.8
15
21
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
7.4
6.8
15
21
W00
ICD-10 Finland
Fall on same level involving ice and snow
2.4
6.7
49
223
L13
ICPC
Hip symptom/complaint
2.2
6.7
66
341
NC2AA
NOMESCO Finland
Forearm X-ray examination
6.1
6.7
17
29
M01AE03
ATC
ketoprofen; systemic, rectal
1.9
6.7
111
692
RK110, ,
NOMESCO Finland
12.6
6.6
11
9
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
6.6
85
487
318
Kela drug reimbursment
Teriparatide
71.1
6.4
7
*
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
4.2
6.4
17
42
SPAT1215
SPAT
Assessment of need for medical rehabilitation
4.2
6.4
17
42
WX212
NOMESCO Finland
Femoral plexus blockade
6.2
6.4
16
27
WX110
NOMESCO Finland
Infiltration anesthesia
1.9
6.3
260
2127
75665
ICD-8 Finland
Other congenital anomalies of musculoskeletal system, Exostosis cartilaginea multiplex
+∞
6.3
6
*
2137A
ICD-9 Finland
Benign neoplasm of bone and articular cartilage, Long bones of lower limb
+∞
6.3
6
*
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
3.1
6.3
26
88
3870A
ICD-9 Finland
Otosclerosis involving oval window, nonobliterative
27.2
6.3
8
*
L99
ICPC
Musculoskeletal disease other
5.5
6.2
17
32
N02BF02
ATC
pregabalin; oral
2.8
6.1
31
118
G47.3
ICD-10 Finland
Sleep apnoea
2.0
6.1
79
452
NGJ60
NOMESCO Finland
Internal fixation of fracture of knee or lower leg using intramedullary nail, other or unspecified
10.3
6.1
11
11
S22.3
ICD-10 Finland
Fracture of rib
2.9
6.0
29
107
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
59
11
64.69
105.41
4.4
1.8
102.11
49.54
ug/l
1.97
59
11
227
1354
3.04
20.81
12.8
8.1
1.22
1.22
mmol/l
0.17
208
1181
212
1231
2.92
20.20
12.7
7.7
1.22
1.22
mmol/l
0.31
206
1153
154
949
2.14
10.50
5.3
3.5
7.36
8.23
mmol/l
1.15
142
824
269
2124
2.28
8.81
10.9
7.7
88.56
82.25
u/l
1.07
264
2021
58
259
2.49
8.33
14.1
10.9
26.05
24.92
mmol/l
1.76
58
259
142
908
1.97
8.25
4.3
3.1
2.36
2.36
mmol/l
0.14
136
838
36
127
3.05
8.08
2.0
1.6
—
—
—
0
0
18
44
4.26
6.90
1.4
1.3
—
—
—
0
0
24
75
3.37
6.56
2.0
2.3
8.85
2.44
index
0.48
13
39
109
702
1.81
5.80
2.8
2.4
—
—
—
0
0
16
41
4.05
5.78
1.4
1.1
—
—
—
0
0
53
266
2.18
5.77
9.5
10.8
1.40
1.06
mmol/l
0.27
44
231
53
271
2.13
5.50
9.9
10.6
5.19
5.28
kpa
0.29
53
263
53
271
2.13
5.50
9.8
10.5
14.25
12.77
kpa
1.05
53
263
220
1758
1.71
5.21
11.6
10.6
3.81
3.92
e9/l
0.42
186
1529
176
1327
1.68
5.19
3.3
2.9
—
—
estimate
—
0
0
70
412
1.88
4.89
2.5
1.8
—
—
—
0
0
56
312
1.95
4.59
6.1
6.8
1.42
1.75
mmol/l
0.34
51
260
207
1658
1.64
4.58
6.5
5.6
6.28
6.46
mmol/l
0.71
199
1547
17
55
3.20
4.42
2.9
4.6
5.92
7.37
pmol/l
0.47
17
55
54
302
1.94
4.38
2.4
1.7
—
—
—
0
0
152
1143
1.60
4.27
6.1
5.6
36.29
37.05
g/l
0.93
142
1088
14
41
3.52
4.23
1.4
1.6
—
—
—
0
0
54
309
1.89
4.09
2.3
1.7
—
—
—
0
0
38
192
2.10
4.07
2.5
3.6
4.63
4.73
pmol/l
0.24
33
166
40
211
2.02
3.83
1.9
1.5
21.62
19.96
iu/l
0.13
32
166
32
159
2.12
3.59
1.6
1.5
13.29
8.28
u/l
0.74
23
114
0
93
0.00
3.51
0.0
1.3
—
—
—
0
0
9
18
5.10
3.39
2.2
2.1
0.89
0.72
index
—
9
18
15
54
2.86
3.30
3.9
3.3
1.19
2.15
ratio
—
6
33
109
797
1.54
3.28
5.5
3.6
0.16
0.28
e6/l
1.06
76
577
13
41
3.26
3.09
1.2
1.2
—
—
—
0
0
70
468
1.62
3.07
5.4
3.4
3.12
2.21
e6/l
0.41
30
231
8
16
5.09
3.07
1.1
1.1
85.50
64.56
u/l
—
8
16
9
21
4.37
3.01
3.3
5.4
0.34
2.36
ug/l
—
9
21
325
3058
2.42
2.99
24.1
16.3
67.46
71.20
umol/l
2.37
325
3023
177
1467
1.43
2.71
7.3
6.6
10.96
11.59
umol/l
0.18
167
1400
16
67
2.46
2.67
2.6
1.1
—
—
—
0
0
16
67
2.46
2.67
2.6
1.1
—
—
—
0
0
72
501
1.55
2.66
5.4
3.3
0.94
0.84
e6/l
0.13
32
260
5
7
7.23
2.55
1.8
1.3
86.60
65.64
ng/l
—
5
7
6
11
5.53
2.55
1.2
2.1
148.50
148.27
%
—
6
11
10
31
3.29
2.54
1.1
1.2
—
—
—
0
0
46
293
1.66
2.44
6.7
6.7
5.51
4.68
kpa
1.21
46
288
55
368
1.59
2.40
10.0
8.2
103.80
104.35
mmol/l
0.29
55
368
8
22
3.70
2.38
1.8
1.6
—
—
—
0
0
295
2733
1.60
2.27
6.3
5.2
1.73
1.84
mu/l
0.82
282
2563
35
212
1.73
2.24
13.6
5.1
1.86
1.05
mmol/l
0.54
27
151
95
724
1.43
2.23
2.9
2.4
2.47
2.84
mg/l
1.30
82
630
287
2651
1.53
2.15
18.5
12.2
92.77
89.20
ml/min/173m2
1.70
262
2392
16
75
2.19
2.12
1.8
1.8
221.39
133.21
ug/l
0.39
16
69
66
474
1.49
2.10
2.8
2.5
2.46
2.43
mmol/l
1.40
61
422
9
31
2.95
2.08
1.7
5.0
—
—
—
0
0
260
2363
1.43
2.05
5.5
4.3
14.55
14.61
pmol/l
0.15
246
2180
38
242
1.64
2.03
3.1
3.1
—
—
—
0
0
21
112
1.93
2.01
2.4
5.1
163.90
176.48
%
0.39
21
112
136
1119
1.36
2.00
2.3
1.9
101.57
97.94
pmol/l
0.36
66
549
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
6
16
3.80
1.94
1.2
1.7
107.33
141.13
%
—
6
16
61
439
1.47
1.92
2.5
2.4
13.02
14.17
umol/l
0.56
56
409
14
65
2.20
1.90
1.4
1.3
1.54
3.32
ug/l
2.09
14
58
50
347
1.52
1.88
1.4
1.6
1164.60
1192.20
nmol/l
0.08
40
265
38
252
1.57
1.75
4.6
8.6
8.24
7.11
mmol/l
0.43
38
244
65
483
1.43
1.74
1.7
1.7
296610625.78
27990884.63
pmol/l
0.69
59
418
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
13
61
2.18
1.74
3.4
6.3
0.42
0.36
iu/ml
—
7
34
29
182
1.65
1.67
2.5
1.6
—
—
—
0
0
238
2163
1.33
1.65
5.7
4.3
11.78
9.75
mm/h
1.63
231
2028
12
56
2.18
1.63
2.2
3.5
6.01
4.92
kpa
1.17
12
56
82
648
1.35
1.53
3.4
3.5
2246.16
811.53
ng/l
1.10
66
546
178
1565
1.29
1.52
4.7
3.7
0.00
5.08
estimate
0.50
38
320
7
27
2.63
1.52
1.3
1.2
—
—
—
0
0
172
1507
1.29
1.51
3.3
3.2
91.05
96.49
ug/l
0.18
163
1428
307
2922
1.52
1.50
19.8
13.4
23.07
21.09
mg/l
0.56
263
2306
5
16
3.16
1.44
1.0
2.1
—
—
—
0
0
176
1554
1.27
1.42
4.7
3.7
0.00
0.00
estimate
-0.00
40
321
81
646
1.33
1.42
1.8
2.3
2.06
1.13
mg/l
0.45
65
499
178
1578
1.27
1.38
4.8
3.7
0.00
0.00
estimate
-0.00
39
296
94
771
1.30
1.35
3.9
4.0
13.17
8.62
mg/mmol
0.26
58
489
15
84
1.82
1.29
2.0
2.3
—
—
—
0
0
5
18
2.80
1.29
2.8
3.9
1180.00
1102.94
mg
—
5
18
5
18
2.80
1.29
1.4
1.0
89.20
87.22
%
—
5
18
16
92
1.78
1.27
1.4
1.3
—
—
—
0
0
13
70
1.89
1.25
1.7
2.3
—
—
—
0
0
27
181
1.53
1.23
1.5
2.5
1817.21
5149.26
u/l
—
8
76
61
478
1.34
1.20
3.6
3.3
208.88
250.34
ng/l
0.11
49
322
6
26
2.33
1.19
4.0
3.7
—
—
—
0
0
14
79
1.81
1.18
1.4
2.1
—
—
—
0
0
10
50
2.03
1.17
1.3
1.5
—
—
—
0
0
8
39
2.08
1.16
1.3
1.6
—
—
—
0
0
5
20
2.52
1.15
1.0
1.1
—
—
—
0
0
22
144
1.56
1.12
4.9
5.8
1.20
1.42
%
0.52
22
144
331
3236
1.86
1.11
29.7
20.6
89.97
89.87
fl
0.14
331
3214
331
3236
1.86
1.11
30.8
21.1
40.49
40.68
%
0.37
331
3212
5
21
2.40
1.09
1.0
1.1
92.60
109.95
pmol/l
—
5
21
122
1058
1.24
1.09
3.3
3.5
31.59
30.87
u/l
0.09
116
1015
315
3046
1.46
1.04
14.4
11.0
27.34
26.96
u/l
0.16
307
2987
5
22
2.29
1.03
1.2
1.4
—
—
—
0
0
80
665
1.27
1.03
2.7
3.3
328.80
332.07
umol/l
0.11
75
602
331
3239
1.83
1.00
30.0
20.7
134.65
136.32
g/l
1.27
331
3216
70
576
1.27
0.98
1.4
1.3
11.32
29.32
iu/ml
3.62
15
169
222
2062
1.22
0.98
3.5
3.6
41.31
41.84
u/l
0.04
211
1981
21
141
1.52
0.97
5.1
5.9
0.41
0.60
%
2.57
21
141
21
141
1.52
0.97
1.3
2.1
1.60
5.36
iu/ml
—
5
38
19
126
1.54
0.93
1.1
1.1
1.44
1.53
g/l
0.81
19
126
13
78
1.69
0.93
1.4
1.3
386.43
314.68
ug/g
—
7
48
6
29
2.09
0.89
1.2
1.1
—
—
—
0
0
10
56
1.81
0.88
1.4
1.2
2315.20
7163.59
e6/l
—
5
37
8
46
1.76
0.83
1.4
1.3
317.13
296.24
mu/l
—
8
38
19
130
1.49
0.83
1.1
1.1
0.98
0.92
g/l
0.45
19
130
0
27
0.00
0.78
0.0
1.4
—
—
—
0
0
6
34
1.78
0.76
1.0
1.2
—
79.00
—
0
6
6
34
1.78
0.76
1.0
1.2
—
—
—
0
0
12
75
1.62
0.76
1.7
1.3
—
—
—
0
0
30
388
0.75
0.76
1.9
1.9
3.91
3.58
ratio
0.61
23
294
6
110
0.54
0.73
1.7
1.6
—
—
—
0
0
19
134
1.44
0.73
1.7
1.3
—
—
—
0
0
10
60
1.69
0.73
1.5
1.4
—
—
—
0
0
20
143
1.42
0.72
10.7
9.8
25.01
24.88
mmol/l
0.04
20
138
14
93
1.53
0.70
1.8
1.7
—
—
—
0
0
28
214
1.34
0.69
1.8
1.5
—
—
—
0
0
24
179
1.37
0.69
2.4
1.5
280.71
309.76
mu/l
0.32
24
164
62
527
1.22
0.67
1.4
1.3
3.82
7.89
u/ml
1.09
20
214
5
29
1.73
0.64
1.0
1.2
—
—
—
0
0
8
50
1.61
0.61
5.8
2.9
128.13
34.51
u/ml
—
8
50
27
210
1.31
0.61
2.6
2.4
0.31
0.57
e6/l
0.25
27
197
0
21
0.00
0.60
0.0
1.6
—
2744.56
—
0
5
24
184
1.33
0.59
2.0
1.6
0.16
0.28
mg/l
—
9
81
6
36
1.68
0.57
2.0
1.5
—
—
—
0
0
12
171
0.69
0.56
1.4
1.5
—
—
—
0
0
13
90
1.46
0.56
1.8
1.6
—
—
—
0
0
6
37
1.63
0.56
2.0
1.5
—
—
—
0
0
6
37
1.63
0.56
2.0
1.5
—
—
—
0
0
14
193
0.71
0.55
1.3
1.2
—
—
—
0
0
9
60
1.51
0.54
1.1
1.2
—
—
—
0
0
6
38
1.59
0.54
1.0
1.2
—
—
—
0
0
6
38
1.59
0.54
2.0
1.5
—
—
—
0
0
6
38
1.59
0.54
2.0
1.5
—
—
—
0
0
9
62
1.46
0.53
1.9
1.8
—
—
—
0
0
15
109
1.39
0.52
1.7
1.6
—
—
—
0
0
24
300
0.78
0.50
1.8
1.7
4.03
3.52
mmol/l
1.43
19
204
236
2265
1.14
0.49
3.5
3.6
—
—
—
0
0
14
102
1.39
0.48
1.1
1.1
—
2.11
—
0
16
5
31
1.62
0.43
1.0
1.2
—
—
—
0
0
5
31
1.62
0.43
1.0
1.2
—
—
—
0
0
6
95
0.63
0.42
1.3
1.4
—
—
—
0
0
62
552
1.15
0.42
4.9
4.6
1.65
2.30
ug/l
0.47
56
496
27
223
1.23
0.41
4.4
5.0
5.27
6.75
ug/l
0.19
17
182
270
2768
0.88
0.39
5.6
5.2
2.85
2.78
mmol/l
0.64
256
2613
9
70
1.29
0.37
2.2
2.2
—
—
—
0
0
9
71
1.27
0.36
1.2
2.8
3.92
3.63
mmol/l
—
9
66
90
830
1.11
0.36
4.8
3.8
0.00
0.00
estimate
0.50
38
305
11
144
0.76
0.34
1.4
1.5
1.12
1.12
ratio
—
6
94
11
144
0.76
0.34
1.4
1.5
0.96
0.96
ratio
—
6
94
11
144
0.76
0.34
1.4
1.5
1.22
1.19
ratio
—
6
94
11
143
0.76
0.32
1.4
1.5
—
—
—
0
0
6
47
1.28
0.32
1.3
1.5
—
—
—
0
0
6
47
1.28
0.32
1.3
1.1
—
—
—
0
0
262
2556
1.11
0.32
5.9
5.6
38.33
38.41
mmol/mol
0.05
254
2441
98
915
1.10
0.31
1.4
1.5
0.61
1.60
u/ml
1.21
21
227
25
212
1.19
0.31
1.0
1.0
—
—
—
0
0
102
955
1.10
0.31
3.6
3.3
48.70
25.30
ng/l
0.44
62
585
7
54
1.30
0.30
1.1
1.1
—
—
—
0
0
97
907
1.10
0.30
2.7
2.5
55.24
61.08
u/l
0.45
86
849
11
141
0.77
0.30
3.5
1.8
—
—
—
0
0
25
290
0.85
0.28
2.2
2.0
—
—
—
0
0
31
352
0.87
0.27
2.4
2.1
—
—
—
0
0
8
67
1.20
0.26
1.1
1.6
—
—
—
0
0
10
77
1.31
0.26
1.5
1.4
—
—
—
0
0
270
2747
0.92
0.23
4.8
4.7
4.76
4.69
mmol/l
0.64
258
2604
5
38
1.32
0.23
2.2
1.5
—
—
—
0
0
12
97
1.25
0.23
1.2
1.3
—
3.13
—
0
13
11
88
1.26
0.23
1.7
3.4
5.40
440.63
u/ml
—
6
80
0
11
0.00
0.21
0.0
1.0
—
13.53
—
0
5
0
11
0.00
0.21
0.0
3.7
—
11.33
—
0
11
0
11
0.00
0.21
0.0
3.7
—
4.59
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
8
103
0.77
0.21
1.1
1.1
—
—
—
0
0
116
1212
0.93
0.21
2.3
2.0
1.52
1.40
mmol/l
0.66
103
1050
8
104
0.76
0.21
1.1
1.1
—
—
—
0
0
14
117
1.21
0.21
1.4
1.6
1.22
1.21
g/l
0.03
14
112
0
13
0.00
0.21
0.0
1.0
—
2.60
—
0
6
10
123
0.81
0.20
1.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
0.44
—
0
6
0
14
0.00
0.20
0.0
1.1
—
0.06
—
0
6
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
122
1173
1.06
0.19
4.1
3.4
0.00
0.00
estimate
0.50
33
270
7
58
1.21
0.18
1.7
1.2
—
—
—
0
0
7
59
1.19
0.18
1.4
1.5
—
—
—
0
0
7
60
1.17
0.18
1.1
1.1
—
—
—
0
0
13
110
1.19
0.17
9.1
8.7
1.80
1.53
%
0.33
13
104
12
141
0.85
0.16
1.3
1.4
276.00
270.35
miu/ml
—
6
77
49
459
1.08
0.15
1.6
1.8
1.40
1.40
%
0.01
43
408
270
2733
0.94
0.14
4.6
4.6
1.40
1.45
mmol/l
1.23
257
2579
10
84
1.20
0.14
2.0
1.9
1.88
4.26
ug/l
—
10
76
266
2627
1.06
0.13
26.0
17.2
332.16
333.33
g/l
1.20
266
2621
11
96
1.15
0.10
1.6
1.7
252.60
183.94
u/ml
—
5
50
36
340
1.07
0.10
3.7
2.9
0.79
0.72
ug/l
0.13
19
196
261
2584
1.04
0.09
3.9
4.0
1.38
1.29
mmol/l
0.80
247
2423
22
204
1.08
0.09
1.2
1.3
—
21.36
—
0
12
23
214
1.08
0.08
2.7
2.9
67.36
70.20
ml/min/173m2
0.09
11
87
49
510
0.95
0.08
1.7
1.5
—
—
—
0
0
24
255
0.94
0.07
6.6
6.8
—
—
—
0
0
10
89
1.13
0.07
1.3
2.0
2.40
5.49
iu/l
—
5
38
14
128
1.10
0.07
1.1
1.2
0.22
3.81
u/ml
—
9
91
26
272
0.95
0.05
1.3
1.3
155.99
176.85
u/ml
—
7
100
12
130
0.92
0.04
1.7
1.6
—
—
—
0
0
71
724
0.98
0.04
4.1
3.4
1.02
1.02
kg/l
0.00
45
464
15
141
1.07
0.03
1.7
1.3
—
—
—
0
0
11
102
1.08
0.03
1.5
1.6
—
—
—
0
0
44
447
0.98
0.01
4.2
4.0
27.02
21.47
%
0.93
15
189
85
843
1.01
0.01
1.8
1.8
—
—
—
0
0
59
592
1.00
0.00
2.0
2.2
—
—
—
0
0
87
871
1.00
0.00
3.9
2.9
0.00
0.00
estimate
-0.00
33
259
264
2641
1.00
0.00
5.0
4.4
5.83
5.79
mmol/l
0.14
250
2466
0
7
0.00
0.00
0.0
5.6
—
—
—
0
0
6
67
0.89
0.00
4.3
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.0
—
—
—
0
0
9
93
0.97
-0.00
1.1
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
37.08
—
0
5
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
54
540
1.00
-0.00
1.9
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
74
0.94
-0.00
1.0
1.1
—
13.19
—
0
17
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
83
0.96
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
8.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
30
300
1.00
-0.00
2.6
4.3
30.20
31.29
%
0.31
20
209
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
87
0.92
-0.00
1.3
1.5
69.64
53.90
ug/l
—
8
87
9
93
0.97
-0.00
1.4
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_OTHER_OSTEOCHONDROD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_OSTEOCHONDROD | 1.735 [1.24, 2.42] | 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 1266 females with Q17_OTHER_OSTEOCHONDROD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_OTHER_OSTEOCHONDROD | 1.75 [1.36, 2.26] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 1206 males with Q17_OTHER_OSTEOCHONDROD died.
Mortality risk
Mortality risk for people of age
years, who have Q17_OTHER_OSTEOCHONDROD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.14% | 0.289% |
| 5 | 0.742% | 1.79% |
| 10 | 2.147% | 4.824% |
| 15 | 3.782% | 9.297% |
| 20 | 6.659% | 15.819% |
Relationships between endpoints
↥Index endpoint: Q17_OTHER_OSTEOCHONDROD – Other osteochondrodysplasias
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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