Congenital varicose veins

Q17_CONGENITAL_VARICOSE_VEINS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q27.4
  • Cause of death: ICD-10 Q27.4

2 out of 7 registries used, show all original rules.

192

4. Check minimum number of events

None

192

5. Include endpoints

None

192

6. Filter based on genotype QC (FinnGen only)

175

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 175 123 52
Unadjusted period prevalence (%) 0.04 0.04 0.02
Median age at first event (years) 40.31 39.86 41.36

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
183
Matched controls
1830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q27.4
ICD-10 Finland
Congenital phlebectasia
+∞
264.8
183
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
45.3
114.8
74
27
D18.0
ICD-10 Finland
Haemangioma, any site
45.5
91.2
57
18
Q27.3
ICD-10 Finland
Peripheral arteriovenous malformation
207.3
34.0
34
*
Q27.9
ICD-10 Finland
Congenital malformation of peripheral vascular system, unspecified
+∞
33.4
31
*
QX3LT
NOMESCO Finland
Subcutaneous sclerotherapy
+∞
23.4
22
*
R4110
NOMESCO Finland
Physiotherapy
4.6
22.9
87
303
ZXD10
NOMESCO Finland
Scheduled procedure
4.4
22.0
107
444
Z2221
NOMESCO Finland
Medical doctor
4.3
21.3
96
375
Q27.88
ICD-10 Finland
Other specified congenital malformation of peripheral vascular system
+∞
20.2
19
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.0
17.8
71
249
D18.1
ICD-10 Finland
Lymphangioma, any site
+∞
16.9
16
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.4
15.3
91
408
XX4BW, ,
NOMESCO Finland
162.4
14.7
15
*
ZXA00
NOMESCO Finland
Right side
3.7
14.4
59
207
EP1LT
NOMESCO Finland
Percutaneous sclerotherapy of vascular malformation of head and neck
+∞
13.7
13
*
Z3226
NOMESCO Finland
Physiotherapist
3.6
13.5
57
203
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.9
12.0
41
126
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.0
11.7
22
41
Q87.21
ICD-10 Finland
Klippel-Trénaunay-Weber syndrome
+∞
11.6
11
*
Q82.50
ICD-10 Finland
Naevus flammeus
116.4
10.5
11
*
JN5LT
NOMESCO Finland
Sclerotherapy with direct puncture body area
+∞
10.5
10
*
QX3KT, ,
NOMESCO Finland
+∞
10.5
10
*
ZXE00
NOMESCO Finland
One hour or less
2.7
10.2
98
543
R4120
NOMESCO Finland
Occupational therapy
4.7
10.0
25
60
ZXA05
NOMESCO Finland
Left side
3.2
10.0
50
195
H02AB07
ATC
prednisone; oral
3.8
9.6
32
96
ZXE20
NOMESCO Finland
More than three and less than five hours
3.6
9.5
35
112
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
9.3
66
310
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
13.5
9.0
15
12
QB9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in torso, unspecified
29.1
8.6
11
*
XX6KT
NOMESCO Finland
Other sclerotherapy
94.2
8.5
9
*
Z3231
NOMESCO Finland
Registered nurse
2.6
8.5
68
338
QD9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in lower extremities, unspecified
+∞
8.4
8
*
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
26.3
7.7
10
*
PG1JT
NOMESCO Finland
Very extensive endovascular embolisation of arterio-venous malformation not elsewhere classified
+∞
7.3
7
*
B01AB05
ATC
enoxaparin; parenteral
2.5
7.3
57
277
Q82.58
ICD-10 Finland
Congenital non-neoplastic naevus
21.0
7.2
10
5
Z71.8
ICD-10 Finland
Other specified counselling
2.3
7.1
86
507
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
41.6
6.8
8
*
Z76.0
ICD-10 Finland
Issue of repeat prescription
2.3
6.8
68
368
WX002
NOMESCO Finland
Sedation and analgesia
2.7
6.5
39
165
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.9
6.5
35
140
22700
ICD-8 Finland
Haemangioma and lymphangioma, Haemangioma
72.3
6.5
7
*
ZXC12
NOMESCO Finland
Pulse colorlaser
72.3
6.5
7
*
R22.4
ICD-10 Finland
Localized swelling, mass and lump, lower limb
9.8
6.4
12
13
QAE40
NOMESCO Finland
Repair of anomaly or lesion after disease of skin of head or neck
+∞
6.3
6
*
XQ800
NOMESCO Finland
Prick test
3.5
6.1
22
69
Z31.5
ICD-10 Finland
Genetic counselling
3.2
6.0
25
86

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
92
351
4.26
21.04
3.3
2.0
1.08
0.82
mg/l
0.68
74
264
26
42
7.05
15.95
1.2
1.1
2.89
2.75
u/ml
0.04
18
20
24
28
9.69
11.96
1.1
1.2
—
—
—
0
0
17
12
15.47
10.72
1.1
1.4
8.84
10.01
umol/l
0.36
17
12
97
548
2.64
9.50
6.7
6.3
—
—
—
0
0
117
759
2.50
8.09
8.5
9.0
0.00
0.00
e9/l
0.11
87
617
83
471
2.39
7.62
4.3
7.1
—
—
—
0
0
88
517
2.35
7.41
3.0
2.4
—
—
—
0
0
122
846
2.33
6.70
6.8
6.5
0.53
0.54
e9/l
0.28
101
750
122
849
2.31
6.60
6.8
6.5
0.04
0.04
e9/l
0.17
101
752
124
881
2.26
6.20
6.9
7.0
0.18
0.18
e9/l
0.16
104
792
123
876
2.23
6.05
7.0
6.5
1.92
1.98
e9/l
0.29
104
796
172
1437
4.28
5.98
20.4
16.6
330.70
333.09
g/l
2.03
172
1431
42
197
2.47
5.67
1.5
1.2
—
—
—
0
0
15
31
5.17
5.25
2.7
1.9
—
—
—
0
0
126
943
2.08
4.96
8.3
10.2
3.66
3.96
e9/l
1.04
102
834
18
57
3.39
4.91
1.2
1.3
—
—
—
0
0
106
748
1.99
4.91
3.2
2.9
—
—
estimate
—
0
0
46
239
2.24
4.88
3.4
2.5
2.41
2.42
mmol/l
0.22
39
215
41
214
2.18
4.27
3.2
2.6
13.97
14.18
umol/l
0.06
41
204
45
244
2.12
4.25
2.8
2.9
2.69
3.76
e6/l
0.24
19
118
23
92
2.72
4.24
4.0
5.2
24.01
23.88
mmol/l
0.09
23
92
84
583
1.81
3.78
3.8
3.8
11.74
20.18
e6/l
0.97
44
383
13
34
4.04
3.78
1.0
1.0
—
—
—
0
0
13
35
3.92
3.67
1.1
1.1
—
—
—
0
0
38
204
2.09
3.66
1.7
2.5
—
—
—
0
0
24
106
2.45
3.64
6.5
9.3
24.03
25.18
mmol/l
0.78
24
106
25
116
2.34
3.41
1.3
1.6
—
—
—
0
0
71
490
1.73
3.13
2.2
2.6
—
0.00
—
0
6
174
1593
2.88
3.09
15.6
13.1
21.71
20.89
mg/l
0.12
146
1243
6
8
7.70
3.08
1.0
1.1
26.33
28.38
s
—
6
8
75
530
1.70
3.01
17.1
9.4
1.21
1.12
inr
0.77
62
435
76
544
1.68
2.88
2.1
1.9
95.75
95.78
pmol/l
0.00
39
296
15
59
2.68
2.87
1.0
1.6
157.60
168.68
u/ml
—
10
31
15
60
2.63
2.78
1.0
1.5
—
—
—
0
0
83
623
1.61
2.53
2.5
1.9
—
—
—
0
0
14
57
2.58
2.51
1.0
1.5
188.00
146.72
au/ml
—
5
16
40
248
1.78
2.50
5.0
3.3
125.46
147.03
ng/l
0.07
26
148
16
70
2.41
2.49
12.8
12.2
0.51
0.66
%
0.86
16
70
88
675
1.59
2.43
6.9
8.4
1.22
1.22
mmol/l
0.05
83
599
5
8
6.39
2.38
1.8
1.1
5.37
5.80
mmol/l
—
5
8
8
23
3.59
2.30
2.6
2.8
71.92
62.86
%
—
8
23
16
73
2.31
2.28
12.9
11.9
1.15
1.39
%
0.66
16
73
26
145
1.92
2.25
1.5
1.5
—
—
—
0
0
5
9
5.67
2.22
1.0
1.3
—
—
—
0
0
28
161
1.87
2.22
9.3
8.2
105.21
104.35
mmol/l
0.43
28
161
176
1654
2.67
2.18
17.0
14.7
70.90
70.06
umol/l
0.13
176
1628
6
14
4.39
2.17
2.8
1.5
—
—
—
0
0
18
90
2.11
2.09
3.4
3.6
61.77
75.66
e9/l
—
7
63
30
180
1.80
2.08
1.4
1.6
—
—
—
0
0
14
63
2.32
2.07
2.5
2.1
—
—
—
0
0
65
483
1.54
1.98
3.0
3.1
13.64
45.80
e6/l
1.51
40
357
23
130
1.88
1.92
9.8
9.8
—
—
—
0
0
72
551
1.51
1.90
1.5
1.6
—
—
—
0
0
25
146
1.83
1.89
3.8
4.9
7.35
7.38
ph
0.56
13
95
11
46
2.48
1.89
1.1
1.3
—
—
—
0
0
31
194
1.72
1.87
1.4
1.3
—
—
—
0
0
57
417
1.53
1.85
4.9
3.9
7.39
7.40
ph
0.13
33
291
175
1652
2.36
1.82
11.7
11.1
—
—
—
0
0
28
174
1.72
1.74
1.8
1.6
—
—
—
0
0
0
47
0.00
1.73
0.0
15.5
—
1.60
—
0
41
42
293
1.56
1.67
1.5
1.7
—
—
—
0
0
29
185
1.67
1.64
1.4
1.4
—
—
—
0
0
25
154
1.72
1.60
1.4
1.6
16.46
19.79
iu/l
0.21
19
126
45
324
1.52
1.55
5.0
4.3
—
—
—
0
0
5
15
3.40
1.53
1.0
1.1
—
—
—
0
0
5
15
3.40
1.53
3.4
3.5
11.52
11.09
%
—
5
15
0
45
0.00
1.52
0.0
16.0
—
0.77
—
0
39
55
420
1.44
1.41
2.9
2.9
0.13
0.24
e6/l
0.82
30
295
7
29
2.47
1.40
1.1
1.4
—
—
—
0
0
69
553
1.40
1.35
2.1
2.2
—
—
—
0
0
6
132
0.44
1.34
2.3
2.5
—
—
—
0
0
12
62
2.00
1.31
1.2
1.3
—
—
—
0
0
141
1278
1.45
1.30
4.1
4.6
14.51
14.48
pmol/l
0.05
132
1198
54
420
1.41
1.24
2.9
2.8
—
—
estimate
—
0
0
8
37
2.21
1.23
2.0
3.2
0.25
3.57
index
—
8
21
5
19
2.68
1.22
1.4
1.6
—
—
nmol/l
—
0
0
6
122
0.47
1.10
1.2
1.1
—
—
—
0
0
7
32
2.23
1.09
1.0
1.0
—
—
—
0
0
0
31
0.00
0.97
0.0
2.1
—
129.00
—
0
22
31
228
1.43
0.97
1.3
1.3
—
—
—
0
0
6
27
2.26
0.94
1.3
1.3
—
—
—
0
0
10
55
1.87
0.94
2.5
2.1
—
—
—
0
0
34
438
0.73
0.91
2.6
3.3
0.00
0.00
estimate
—
9
148
6
29
2.10
0.90
1.3
1.3
—
—
—
0
0
94
829
1.28
0.87
5.7
5.7
5.89
6.33
mmol/l
2.49
87
771
157
1484
1.41
0.84
5.0
5.4
1.50
1.78
mu/l
4.56
152
1415
17
114
1.54
0.83
1.0
1.5
—
—
—
0
0
18
123
1.51
0.81
11.8
13.5
7.36
7.43
ph
—
5
69
0
26
0.00
0.79
0.0
3.5
—
19.75
—
0
26
17
119
1.47
0.70
1.6
1.7
—
—
—
0
0
13
86
1.55
0.68
1.6
1.5
—
—
—
0
0
5
28
1.81
0.66
2.0
2.0
14.00
33.25
ng/l
—
5
28
24
183
1.36
0.63
1.5
1.5
—
—
—
0
0
8
50
1.63
0.62
2.6
3.9
10.75
113.19
u/ml
—
8
42
0
20
0.00
0.60
0.0
14.9
—
940.65
—
0
20
13
89
1.50
0.60
1.7
1.6
—
—
—
0
0
0
22
0.00
0.59
0.0
10.9
—
0.63
—
0
22
0
22
0.00
0.59
0.0
22.3
—
1638.32
—
0
22
54
466
1.23
0.57
1.6
1.5
2.10
2.14
g/l
0.07
33
291
6
40
1.52
0.52
1.2
1.1
—
—
—
0
0
27
331
0.78
0.51
1.4
1.3
3.98
8.26
u/ml
—
10
127
15
112
1.37
0.46
1.2
1.1
—
16.20
—
0
5
126
1194
1.18
0.43
3.2
3.6
40.16
38.60
u/l
0.07
121
1156
5
31
1.63
0.43
1.0
1.1
—
—
—
0
0
14
105
1.36
0.42
8.0
4.8
120.12
69.07
ng/l
1.05
14
99
0
15
0.00
0.41
0.0
2.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
0.28
—
0
7
0
16
0.00
0.41
0.0
3.1
—
47.67
—
0
6
0
17
0.00
0.41
0.0
1.1
—
0.24
—
0
10
0
17
0.00
0.41
0.0
2.0
—
11.47
—
0
17
36
309
1.21
0.40
2.1
2.5
4.93
8.00
e6/l
1.31
31
281
0
18
0.00
0.40
0.0
4.4
—
61.83
—
0
6
5
35
1.44
0.39
1.0
2.0
—
—
—
0
0
69
629
1.16
0.39
2.4
1.9
1.21
1.35
mmol/l
1.17
64
558
9
67
1.36
0.38
1.0
1.1
—
—
—
0
0
32
273
1.21
0.38
2.2
2.3
631.48
552.85
mosm/kgh2o
1.01
27
236
32
371
0.83
0.37
3.9
3.4
26.42
66.56
mg/l
1.78
24
234
16
127
1.28
0.35
2.9
2.3
9.66
13.33
nmol/l
0.94
16
120
49
440
1.16
0.33
1.7
1.8
—
—
—
0
0
42
470
0.86
0.33
2.2
3.1
35.54
34.75
ng/l
0.01
20
243
74
686
1.13
0.32
2.4
2.6
—
—
—
0
0
17
138
1.26
0.32
2.1
2.5
0.60
0.73
ug/l
—
5
73
18
148
1.24
0.30
2.5
1.9
—
—
—
0
0
91
858
1.12
0.29
2.8
3.3
0.00
0.00
estimate
—
9
154
7
57
1.24
0.29
1.3
1.1
—
—
—
0
0
18
149
1.23
0.29
2.6
1.9
—
—
—
0
0
8
62
1.30
0.28
2.6
3.3
0.55
0.65
%
—
8
62
22
187
1.20
0.28
1.4
1.9
2.99
3.46
mmol/l
1.46
16
137
89
840
1.12
0.28
2.8
3.2
0.00
0.00
estimate
—
9
160
18
150
1.22
0.27
2.6
1.9
—
—
—
0
0
18
150
1.22
0.27
2.6
1.9
—
—
—
0
0
14
113
1.26
0.27
1.4
1.2
—
—
—
0
0
39
350
1.15
0.27
1.5
1.6
—
—
—
0
0
10
77
1.32
0.26
1.0
1.0
1.53
1.59
g/l
—
10
77
12
148
0.80
0.25
2.7
2.0
10.07
10.24
g/l
0.07
12
141
10
126
0.78
0.25
2.7
1.8
1.84
1.36
g/l
—
10
120
9
76
1.19
0.25
3.6
2.4
—
—
—
0
0
15
125
1.22
0.23
2.7
2.0
—
—
—
0
0
10
79
1.28
0.23
1.0
1.2
0.97
0.88
g/l
—
10
79
10
79
1.28
0.23
1.1
1.2
—
—
—
0
0
5
40
1.26
0.22
1.4
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
209.73
—
0
11
0
10
0.00
0.21
0.0
1.0
—
152.07
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
3.90
—
0
13
0
13
0.00
0.21
0.0
2.2
—
107.23
—
0
13
0
13
0.00
0.21
0.0
2.2
—
1.19
—
0
13
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
6
51
1.18
0.19
1.7
1.3
—
—
—
0
0
34
372
0.89
0.19
4.0
3.8
2.72
10.36
mg/mmol
2.60
25
229
13
109
1.21
0.19
2.8
2.4
—
—
—
0
0
7
86
0.81
0.15
3.1
6.1
—
—
—
0
0
51
483
1.08
0.14
2.0
2.5
0.00
0.01
estimate
—
6
128
54
513
1.07
0.13
1.5
1.5
1.14
1.45
u/ml
0.19
14
132
16
142
1.14
0.13
2.6
1.9
—
—
—
0
0
19
210
0.89
0.13
1.2
1.2
—
—
—
0
0
61
636
0.94
0.12
2.3
2.9
0.00
0.01
estimate
—
7
139
88
854
1.06
0.11
2.8
3.2
0.00
8.80
estimate
—
9
160
13
115
1.14
0.11
1.3
1.1
—
—
—
0
0
40
421
0.94
0.10
3.2
3.9
—
—
—
0
0
72
697
1.05
0.10
3.0
3.0
6.11
6.20
ph
0.27
31
378
5
45
1.11
0.10
1.8
1.6
0.45
0.65
g/l
—
5
40
13
116
1.13
0.09
1.8
1.9
—
—
—
0
0
5
47
1.07
0.09
1.8
1.3
—
—
—
0
0
14
127
1.11
0.08
2.4
2.0
178.20
4948.57
u/l
—
5
47
38
366
1.05
0.05
1.3
1.3
9.43
21.87
iu/ml
—
9
101
144
1454
0.95
0.05
3.7
4.0
5.56
5.67
mmol/l
0.53
139
1369
41
397
1.04
0.05
2.5
3.1
1.02
1.02
kg/l
0.01
24
242
10
107
0.93
0.02
1.5
1.2
—
—
—
0
0
21
209
1.01
0.00
2.1
1.9
—
—
—
0
0
34
343
0.99
0.00
2.6
1.9
—
—
—
0
0
41
405
1.02
0.00
3.0
2.5
—
—
—
0
0
47
468
1.01
0.00
3.6
3.2
8.85
8.30
mmol/l
0.25
42
413
5
49
1.02
0.00
1.0
1.1
—
—
—
0
0
6
62
0.97
0.00
1.5
1.5
—
—
—
0
0
6
62
0.97
0.00
1.5
1.5
—
101.67
—
0
6
5
49
1.02
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
15.0
—
17.06
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
1762.38
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
1.19
—
0
8
0
5
0.00
-0.00
0.0
2.8
—
1809.00
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
3.20
—
0
5
0
7
0.00
-0.00
0.0
1.6
—
0.00
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
163.44
—
0
8
0
5
0.00
-0.00
0.0
1.4
—
21.80
—
0
5
9
91
0.99
-0.00
1.6
1.8
—
4.72
—
0
18
0
5
0.00
-0.00
0.0
1.2
—
56.40
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
10.3
—
7.41
—
0
8
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
7.3
—
9.38
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.1
—
147.71
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
453.67
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: Q17_CONGENITAL_VARICOSE_VEINS – Congenital varicose veins

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).