No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
58 |
4. Check minimum number of eventsNone |
58 |
5. Include endpointsNone |
58 |
6. Filter based on genotype QC (FinnGen only) |
52 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Similar endpoints
↥List of similar endpoints to
Aortic stenosis
based on the number of shared cases.
Similar with more cases:
- Aortic stenosis, including avohilmo
- Congenital malformations of great arteries
- Left ventricular outflow tract obstruction, narrow definition
- Left ventricular outflow tract obstruction (LVOTO), broad definition
- Congenital malformations of heart and great arteries
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 52 | 25 | 27 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 31.48 | 29.73 | 33.10 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 56
- Matched controls
- 560
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
80.2
56
*
Q25.1
ICD-10 Finland
Coarctation of aorta
302.8
21.1
20
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
13.2
20.5
41
96
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
29.7
20.4
28
18
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
12.5
19.1
25
34
TPH07
NOMESCO Finland
Cathetrisation of artery
11.4
18.8
28
45
I35.0
ICD-10 Finland
Aortic (valve) stenosis
37.7
18.3
23
10
ZXE20
NOMESCO Finland
More than three and less than five hours
10.9
16.8
24
36
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
23.1
14.6
21
14
C03CA01
ATC
furosemide; systemic
7.6
13.2
32
84
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.3
12.6
29
72
B01AA03
ATC
warfarin; systemic
8.5
12.6
21
37
XF400
NOMESCO Finland
ECG with 12 standard connections
7.2
12.1
26
60
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
7.2
12.1
26
60
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
134.1
10.8
11
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
119.4
9.7
10
*
WX408
NOMESCO Finland
General anesthesy, balanced
5.7
9.7
30
94
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
29.8
9.4
12
5
FM2CE, ,
NOMESCO Finland
18.1
9.3
14
10
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
13.5
9.3
16
16
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.9
9.2
40
166
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
16.5
9.0
14
11
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
5.4
8.6
24
68
Q23.11
ICD-10 Finland
Bicuspid aortic valve
52.6
8.0
9
*
ZXD10
NOMESCO Finland
Scheduled procedure
4.9
7.9
34
135
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
91.7
7.6
8
*
61
HP
Catheterization and pressure measurement of the left side of the heart
91.7
7.6
8
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
7.4
7
*
I50.9
ICD-10 Finland
Heart failure, unspecified
5.4
7.3
18
45
WX892
NOMESCO Finland
Monitored bed care
7.0
6.5
16
30
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
30.5
6.4
8
*
31
HP
Congenital heart failure surgery
+∞
6.4
6
*
TPH04
NOMESCO Finland
Cathetrisation of vein
4.4
6.4
22
72
XF600
NOMESCO Finland
Bloodpressure measurement
6.6
6.2
16
32
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
41
130
9.04
14.24
11.0
4.8
2609.73
1497.95
ng/l
0.71
41
106
29
76
6.84
11.79
5.0
6.0
31.71
30.18
s
0.65
29
76
20
40
7.22
10.50
8.6
9.3
80.50
84.62
%
0.29
20
40
31
105
5.37
9.05
4.3
4.1
—
—
—
0
0
17
32
7.15
6.87
3.9
9.5
198.65
180.25
%
0.36
17
32
26
102
3.89
5.78
4.0
4.2
1.54
1.89
mg/l
0.16
19
83
20
74
3.65
4.71
2.7
2.1
—
—
—
0
0
23
95
3.41
4.56
3.0
2.2
—
—
—
0
0
14
41
4.22
4.53
9.4
22.4
1.04
1.11
%
0.23
14
41
25
113
3.19
4.23
15.1
12.1
1.33
1.29
mmol/l
0.20
25
108
14
40
4.32
3.97
9.4
22.8
0.85
0.60
%
2.42
14
40
35
201
2.98
3.77
5.0
3.8
—
—
estimate
—
0
0
27
140
2.79
3.44
4.8
4.1
27.74
43.90
ng/l
0.49
19
95
18
75
3.06
3.40
3.0
2.2
—
—
—
0
0
19
84
2.91
3.22
12.7
20.0
105.84
103.76
mmol/l
1.10
19
84
5
5
10.79
3.03
2.8
3.0
94.40
93.60
g/l
—
5
5
22
114
2.53
2.69
19.7
24.3
25.05
24.69
mmol/l
0.28
22
114
5
8
6.72
2.42
2.4
5.5
100.80
106.50
%
—
5
8
5
8
6.72
2.42
2.8
14.5
4.84
4.70
kpa
—
5
8
5
8
6.72
2.42
2.8
14.5
6.56
5.92
kpa
—
5
8
6
13
5.03
2.34
1.8
1.3
—
—
—
0
0
6
13
5.03
2.34
1.0
1.6
—
—
—
0
0
8
26
3.41
2.11
1.8
2.4
—
—
—
0
0
5
13
4.11
1.75
1.8
2.2
—
—
—
0
0
6
19
3.41
1.71
1.7
2.0
—
—
—
0
0
5
14
3.81
1.65
1.0
1.6
—
—
—
0
0
7
26
2.93
1.64
1.9
2.3
—
—
—
0
0
40
311
2.00
1.50
31.9
14.6
75.62
86.68
ml/min/173m2
1.61
34
279
9
41
2.42
1.45
2.4
1.6
—
—
—
0
0
28
196
1.86
1.42
7.1
4.9
—
—
—
0
0
5
18
2.94
1.31
1.0
2.2
—
—
—
0
0
48
413
2.13
1.28
49.8
23.9
331.88
333.44
g/l
0.59
48
413
8
39
2.22
1.21
2.1
1.9
—
—
—
0
0
5
21
2.51
1.11
11.6
9.9
—
618.86
—
0
7
38
311
1.69
0.99
11.9
12.9
4.44
3.81
e9/l
0.90
32
252
51
463
2.13
0.88
18.2
12.2
25.24
24.88
u/l
0.06
51
449
5
26
2.01
0.72
1.2
1.5
—
—
—
0
0
16
113
1.58
0.71
7.7
3.8
1.02
1.02
kg/l
—
10
74
15
105
1.59
0.69
22.1
12.4
1.24
0.84
mmol/l
0.28
15
82
40
348
1.52
0.66
6.1
4.8
1.41
1.41
mmol/l
0.04
40
326
6
34
1.85
0.61
1.7
1.2
—
—
—
0
0
22
173
1.45
0.59
6.2
3.7
0.00
0.00
estimate
—
5
40
40
352
1.48
0.58
7.0
5.4
2.41
2.61
mmol/l
0.85
40
329
31
262
1.41
0.56
5.9
4.2
0.00
0.00
estimate
—
5
47
19
150
1.40
0.49
3.2
2.0
92.00
87.77
pmol/l
—
10
85
31
267
1.36
0.47
6.0
4.3
0.00
0.00
estimate
—
5
43
15
114
1.43
0.47
5.4
5.2
0.62
0.63
e6/l
—
9
60
31
268
1.35
0.45
6.0
4.3
0.00
0.00
estimate
—
5
42
5
32
1.62
0.43
1.2
1.2
—
—
—
0
0
14
109
1.38
0.38
5.4
5.2
2.75
1.89
e6/l
—
8
57
16
130
1.32
0.33
4.8
3.8
50.13
53.38
u/l
0.23
16
123
5
39
1.31
0.23
14.2
11.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
37
348
1.19
0.18
4.0
3.6
—
—
—
0
0
6
53
1.15
0.09
2.3
1.7
1377.28
1175.34
nmol/l
—
6
46
13
118
1.13
0.08
3.8
3.2
0.00
0.00
estimate
—
5
33
14
135
1.05
0.00
1.8
2.2
—
—
—
0
0
34
338
1.02
0.00
8.4
5.4
39.82
38.82
mmol/mol
0.28
34
311
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
1.17
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
105.54
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
96.60
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
0.81
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
6.14
—
0
7
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
13.94
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.6
—
26.20
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
65
0.91
-0.00
1.2
1.2
—
33.08
—
0
15
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
50.39
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
-0.00
1.5
2.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
6.52
—
0
5
5
57
0.87
-0.00
1.6
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
8
79
1.01
-0.00
2.8
2.9
476.63
352.95
nmol/l
—
8
73
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: Q17_AORTIC_STENOSIS – Aortic stenosis
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).