No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
86 |
4. Check minimum number of eventsNone |
86 |
5. Include endpointsNone |
86 |
6. Filter based on genotype QC (FinnGen only) |
75 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF13
Similar endpoints
↥List of similar endpoints to
Aortic stenosis, including avohilmo
based on the number of shared cases.
Similar with more cases:
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly, including avohilmo
- Congenital malformations, deformations and chromosomal abnormalities, including avohilmo
- Any operation in hilmo
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 75 | 36 | 39 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 56.74 | 58.68 | 54.95 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 81
- Matched controls
- 810
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
116.5
81
*
I35.0
ICD-10 Finland
Aortic (valve) stenosis
24.7
43.9
38
28
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
16.4
31.0
32
31
Q25.1
ICD-10 Finland
Coarctation of aorta
355.2
26.3
25
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.7
25.0
33
45
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
9.1
22.2
54
146
TPH07
NOMESCO Finland
Cathetrisation of artery
8.1
19.0
36
73
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
6.5
15.9
41
111
ZXE20
NOMESCO Finland
More than three and less than five hours
7.4
15.8
30
60
XF400
NOMESCO Finland
ECG with 12 standard connections
6.6
15.6
37
92
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
15.7
14.5
24
21
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.8
13.8
39
112
WX892
NOMESCO Finland
Monitored bed care
7.4
13.3
23
41
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
39.2
13.1
16
5
B01AA03
ATC
warfarin; systemic
5.6
12.4
33
89
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
5.2
12.2
39
123
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
138.9
11.8
12
*
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
21.7
11.3
16
9
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
125.6
10.7
11
*
ZXD10
NOMESCO Finland
Scheduled procedure
4.5
10.2
51
221
C03CA01
ATC
furosemide; systemic
4.4
10.0
45
179
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
9.8
9.9
20
26
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
5.7
9.8
22
50
WX408
NOMESCO Finland
General anesthesy, balanced
4.2
9.4
41
158
Q23.11
ICD-10 Finland
Bicuspid aortic valve
41.8
9.3
11
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.5
9.1
58
292
FM2CE, ,
NOMESCO Finland
12.8
8.7
15
14
TPH04
NOMESCO Finland
Cathetrisation of vein
3.9
7.9
32
115
Z2221
NOMESCO Finland
Medical doctor
3.7
7.7
37
149
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
87.8
7.6
8
*
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
+∞
7.4
7
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
7.4
7
*
XF600
NOMESCO Finland
Bloodpressure measurement
4.6
6.8
19
51
ZXE30
NOMESCO Finland
More than five and less than seven hours
7.4
6.5
15
24
Q25.40
ICD-10 Finland
Aortic hypoplasia
75.6
6.5
7
*
Z98.8
ICD-10 Finland
Other specified postsurgical states
20.0
6.4
9
5
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
20.0
6.4
9
5
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
7.1
6.4
15
25
31
HP
Congenital heart failure surgery
+∞
6.3
6
*
AB2
HP
AVR bio, stent
+∞
6.3
6
*
61
HP
Catheterization and pressure measurement of the left side of the heart
16.6
6.1
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
150
6.08
15.01
3.7
3.7
—
—
—
0
0
52
233
4.44
9.79
9.8
5.1
2790.48
1737.51
ng/l
0.79
52
191
31
97
4.56
9.44
11.0
12.5
8.60
7.29
mmol/l
0.54
31
92
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
19
10.19
8.29
15.9
10.4
0.40
0.34
iu/ml
—
9
10
29
95
4.20
8.18
21.6
22.2
1.18
1.50
mmol/l
0.15
24
80
55
293
3.73
7.33
4.6
3.6
—
—
estimate
—
0
0
26
98
3.43
5.78
2.4
6.3
296.08
331.47
u/l
0.35
26
91
58
354
3.25
5.55
13.0
8.9
26.51
22.79
umol/l
0.24
53
340
33
147
3.10
5.55
4.0
3.7
1.43
1.78
mg/l
0.23
25
119
17
50
4.04
5.37
8.4
18.6
0.74
0.59
%
0.86
17
50
17
52
3.87
5.08
8.4
18.1
1.06
1.09
%
0.10
17
52
60
387
3.12
4.96
16.0
14.6
1.21
1.21
mmol/l
0.35
53
345
28
124
2.92
4.65
14.3
16.4
104.43
103.63
mmol/l
0.37
28
124
13
28
5.32
4.61
8.1
25.3
62.95
68.12
%
0.46
13
28
31
152
2.68
4.20
2.9
2.1
—
—
—
0
0
6
5
12.80
3.82
3.3
3.0
94.17
93.60
g/l
—
6
5
25
116
2.67
3.72
2.7
2.0
—
—
—
0
0
37
210
2.40
3.59
2.9
2.9
2.52
2.81
mg/l
0.35
31
185
27
133
2.55
3.55
20.4
22.6
25.52
24.78
mmol/l
0.64
27
133
6
8
7.98
3.11
3.3
14.5
5.13
4.70
kpa
—
6
8
6
8
7.98
3.11
3.3
14.5
6.55
5.92
kpa
—
6
8
61
450
2.44
3.03
10.3
12.4
4.42
4.10
e9/l
0.49
50
375
23
116
2.37
2.81
3.0
2.1
—
—
—
0
0
39
246
2.13
2.78
5.2
4.5
31.77
51.33
ng/l
0.69
26
179
7
17
4.40
2.42
1.9
1.2
—
—
—
0
0
43
299
1.93
2.20
6.1
4.6
—
—
—
0
0
5
10
5.25
2.10
2.4
4.9
100.80
101.70
%
—
5
10
76
671
3.15
1.98
37.3
18.6
29.43
24.17
mg/l
0.75
69
551
13
59
2.43
1.96
2.5
1.6
—
—
—
0
0
61
493
1.96
1.83
11.7
8.2
104.70
101.36
u/l
0.06
56
462
6
18
3.51
1.78
1.0
1.4
—
—
—
0
0
37
260
1.78
1.72
5.2
4.4
0.19
0.32
e6/l
0.51
31
189
61
498
1.91
1.71
34.1
18.3
76.17
80.19
ml/min/173m2
0.65
54
456
14
71
2.17
1.66
5.1
3.4
24.22
26.62
u/l
—
9
55
6
20
3.15
1.61
1.0
1.4
—
—
—
0
0
9
37
2.61
1.53
1.7
2.1
—
—
—
0
0
12
59
2.21
1.52
1.8
1.8
—
—
—
0
0
6
22
2.86
1.46
2.8
1.7
—
—
—
0
0
25
164
1.76
1.43
4.6
4.6
1.04
0.58
e6/l
0.63
14
89
24
157
1.75
1.38
4.6
4.8
7.77
1.71
e6/l
0.84
13
84
5
17
3.06
1.38
1.4
3.6
0.00
0.00
g/l
—
5
17
5
18
2.89
1.30
1.4
3.5
0.00
0.00
g/l
—
5
18
8
37
2.29
1.25
1.8
2.0
—
—
—
0
0
36
269
1.61
1.25
3.2
2.2
90.74
90.69
pmol/l
0.00
19
140
5
19
2.73
1.23
1.8
1.9
—
—
—
0
0
6
26
2.41
1.21
2.8
2.0
—
—
—
0
0
7
30
2.46
1.15
1.6
1.7
—
—
—
0
0
6
30
2.08
0.89
1.2
1.2
—
—
—
0
0
6
31
2.01
0.86
1.2
1.2
—
—
—
0
0
56
491
1.46
0.78
4.9
4.8
16.04
12.71
mm/h
0.69
51
451
5
23
2.25
0.77
1.0
1.9
—
—
—
0
0
5
23
2.25
0.77
2.4
1.5
—
—
—
0
0
17
119
1.54
0.74
20.2
12.1
1.42
1.01
mmol/l
0.32
17
91
5
25
2.06
0.74
2.6
1.6
—
—
—
0
0
5
25
2.06
0.74
2.6
1.6
—
—
—
0
0
5
25
2.06
0.74
11.6
10.6
—
567.00
—
0
8
7
43
1.69
0.69
1.9
1.2
—
—
—
0
0
52
457
1.39
0.66
3.9
3.4
—
—
—
0
0
44
387
1.30
0.50
4.9
4.5
0.00
0.00
estimate
—
8
76
7
46
1.57
0.50
1.1
1.2
—
—
—
0
0
5
31
1.65
0.44
9.2
3.0
1.40
1.27
index
—
5
15
44
393
1.26
0.42
5.0
4.6
0.00
21.09
estimate
—
8
77
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
44
394
1.26
0.41
5.0
4.6
0.00
0.00
estimate
—
8
72
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
15
120
1.31
0.33
4.1
3.3
0.74
0.81
ug/l
—
10
81
5
37
1.37
0.24
1.2
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
4.0
—
2067.14
—
0
11
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
8
70
1.16
0.17
1.6
2.2
—
—
—
0
0
17
152
1.15
0.13
5.5
5.0
20.71
22.10
%
—
8
79
23
211
1.13
0.13
6.6
4.4
0.00
0.00
estimate
—
7
69
6
53
1.14
0.09
1.7
1.3
—
—
—
0
0
5
63
0.78
0.08
14.2
12.1
—
—
—
0
0
7
64
1.10
0.08
1.6
2.1
—
—
—
0
0
21
196
1.10
0.08
4.9
4.0
7.67
10.41
mg/mmol
0.33
13
128
8
73
1.11
0.08
6.5
3.5
—
—
—
0
0
17
160
1.08
0.04
1.9
2.1
—
—
—
0
0
18
187
0.95
0.01
3.9
3.5
0.00
0.00
estimate
—
7
58
27
267
1.02
0.00
5.8
4.3
0.00
0.00
estimate
—
8
63
17
169
1.01
0.00
7.3
4.6
1.01
1.02
kg/l
0.83
11
116
10
99
1.01
0.00
2.4
2.7
455.00
377.97
nmol/l
—
10
92
0
9
0.00
-0.00
0.0
1.2
—
0.81
—
0
9
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
50.39
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.8
—
9.52
—
0
5
20
200
1.00
-0.00
4.5
3.3
50.75
55.15
u/l
0.38
20
187
0
6
0.00
-0.00
0.0
1.0
—
89.67
—
0
6
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
6.52
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
14.00
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
14.80
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
87.57
—
0
7
0
6
0.00
-0.00
0.0
2.7
—
92.12
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.8
—
4.53
—
0
5
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.17
—
0
6
6
60
1.00
-0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
13.94
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
6.40
—
0
8
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: Q17_AORTIC_STENOSIS_WIDE – Aortic stenosis, including avohilmo
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).