nephrosclerosis: Hardening of the walls of the small arteries and arterioles (small arteries that convey blood from arteries to the even smaller capillaries) of the kidney. This condition is caused by hypertension (high blood pressure)
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
234 |
4. Check minimum number of eventsNone |
234 |
5. Include endpointsNone |
234 |
6. Filter based on genotype QC (FinnGen only) |
209 |
Control definitions (FinnGen only)
- Control exclude
- N14_KIDUROTH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- N25-N29
- Name in latin
- Ren contractus non specificatus
Similar endpoints
↥List of similar endpoints to
Unspecified contracted kidney
based on the number of shared cases.
Similar with more cases:
- Other disorders of kidney and ureter
- All kidney diseases
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2426 | 1203 | 1167 |
| Only index persons | 1486 | 779 | 707 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 65.34 | 65.36 | 65.15 |
| Only index persons | 61.79 | 61.91 | 61.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 209 | 95 | 114 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | 57.78 | 55.01 | 60.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 218
- Matched controls
- 2180
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N26
ICD-10 Finland
Unspecified contracted kidney
+∞
242.4
185
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
29.5
129.4
102
63
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
64.3
112.2
64
14
N18.8
ICD-10 Finland
Other chronic renal failure
46.9
106.9
66
20
A11CC03
ATC
alfacalcidol; systemic
57.4
101.3
59
14
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
47.2
84.0
51
14
A12AA04
ATC
calcium carbonate; oral
58.0
79.8
46
10
TK800
NOMESCO Finland
Hemodialysis
30.4
58.2
40
16
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.3
41.6
53
66
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
10.2
40.7
52
65
Z94.0
ICD-10 Finland
Kidney transplant status
147.7
35.9
37
*
137
Kela drug reimbursment
Uraemia requiring dialysis
110.9
34.9
37
*
127
Kela drug reimbursment
Transplant complication
54.0
34.2
40
9
205
Kela drug reimbursment
Chronic hypertension
4.8
29.1
111
390
N18.0
ICD-10 Finland
End-stage renal disease
71.8
27.8
31
5
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.5
27.6
67
162
L04AA06
ATC
mycophenolic acid; systemic
28.4
26.7
36
15
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
106.6
26.3
28
*
L04AD02
ATC
tacrolimus; systemic
79.8
25.5
28
*
B03XA02
ATC
darbepoetin alfa; parenteral
23.7
25.3
36
18
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
49.4
25.3
30
7
B05DB
ATC
Hypertonic solutions
102.3
25.3
27
*
B05DA
ATC
Isotonic solutions
102.3
25.3
27
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
43.1
24.7
30
8
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
9.6
24.6
31
37
Z49.2
ICD-10 Finland
Other dialysis
93.8
23.2
25
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
58.7
22.6
26
5
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
+∞
22.3
21
*
N19
ICD-10 Finland
Unspecified kidney failure
8.5
21.8
30
40
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
121.7
21.0
22
*
M04AA01
ATC
allopurinol; systemic
4.5
20.9
64
184
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
18.8
20.3
31
19
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
80.9
20.1
22
*
I12.0
ICD-10 Finland
Hypertensive renal disease with renal failure
57.7
18.3
21
*
H05BX01
ATC
cinacalcet; oral
73.0
18.0
20
*
5870A
ICD-9 Finland
Renal sclerosis, unspecified[SCLEROSIS RENALIS SECUNDARIA NUD]
+∞
18.0
17
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
31.9
17.8
23
8
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
195.2
17.8
18
*
C03CA01
ATC
furosemide; systemic
3.3
17.2
108
495
TK820
NOMESCO Finland
Peritoneal dialysis
69.0
17.0
19
*
V03AE01
ATC
polystyrene sulfonate; oral
22.3
16.8
24
12
196
Kela drug reimbursment
Paricalcitol and cinacalcet
97.7
16.8
18
*
KBV00
NOMESCO Finland
Insertion of stent into ureter
51.8
16.3
19
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
15.4
16.0
26
19
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.9
15.7
56
177
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.7
15.5
26
43
C02AC05
ATC
moxonidine; oral
6.6
15.2
26
44
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
86.0
14.8
16
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
39.0
14.7
18
5
U14
ICPC
Kidney symptom/complaint
20.9
14.5
21
11
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.5
14.3
64
234
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
45.9
14.3
17
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
45.9
14.3
17
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
32.5
14.1
18
6
58499
ICD-8 Finland
Renal sclerosis, unqualified
+∞
13.7
13
*
H02AB04
ATC
methylprednisolone; systemic
3.6
13.7
54
182
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
148.9
13.6
14
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
6.9
13.6
22
35
R50.9
ICD-10 Finland
Fever, unspecified
3.4
13.0
58
211
N18.3
ICD-10 Finland
Chronic kidney disease, stage 3
13.4
12.9
22
18
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
26.2
12.7
17
7
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.8
12.4
30
70
C08CA01
ATC
amlodipine; oral
2.8
12.3
112
603
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.6
12.3
48
160
V03AE03
ATC
lanthanum carbonate; oral
49.6
12.0
14
*
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
49.6
12.0
14
*
204
Kela drug reimbursment
Leukemia lymphatica
12.8
11.6
20
17
V03AE02
ATC
sevelamer; oral
126.4
11.5
12
*
L04AD01
ATC
ciclosporin; systemic
13.7
11.4
19
15
C08CA02
ATC
felodipine; oral
3.9
11.3
36
104
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.6
11.3
29
71
I15.0
ICD-10 Finland
Renovascular hypertension
45.8
11.0
13
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
10.8
130
787
JN3AD
NOMESCO Finland
Abdominal CT examination
3.3
10.7
46
162
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
115.3
10.5
11
*
Q60.3
ICD-10 Finland
Renal hypoplasia, unilateral
+∞
10.5
10
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.7
10.4
36
110
N18.4
ICD-10 Finland
Chronic kidney disease, stage 4
24.8
10.4
14
6
C07AB02
ATC
metoprolol; systemic
2.8
10.3
65
285
L04AA01
ATC
[U] ciclosporin
21.2
9.9
14
7
59000
ICD-8 Finland
Infections of kidney, Pyelonephritis chronica
57.6
9.7
11
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.6
9.7
36
115
B03XA01
ATC
erythropoietin; parenteral
16.0
9.7
15
10
N11.8
ICD-10 Finland
Other chronic tubulo-interstitial nephritis
+∞
9.4
9
*
N18
ICD-10 Finland
Chronic kidney disease
16.5
9.2
14
9
321
Kela drug reimbursment
Paricalcitol and cinacalcet
38.4
9.1
11
*
UKC02
NOMESCO Finland
Cystoscopy
2.9
9.0
50
203
C09AA02
ATC
enalapril; systemic
2.7
9.0
63
289
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
8.8
67
321
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
52.1
8.7
10
*
WW500
NOMESCO Finland
Blood transfusion
4.4
8.5
22
54
PC5CG
NOMESCO Finland
Extensive MRI examination of kidney vasculature with high intensity magnet
+∞
8.4
8
*
N25.0
ICD-10 Finland
Renal osteodystrophy
+∞
8.4
8
*
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
+∞
8.4
8
*
A41.9
ICD-10 Finland
Sepsis, unspecified
4.7
8.3
20
46
B01AB10
ATC
tinzaparin; parenteral
3.2
8.2
36
128
TK810
NOMESCO Finland
Hemofiltration
34.8
8.1
10
*
M01AE01
ATC
ibuprofen; systemic, rectal
0.4
8.0
126
1653
R4190
NOMESCO Finland
Nutritional therapy
4.8
7.8
18
40
KAC11
NOMESCO Finland
Total nephrectomy with capsule, transcutaneous
46.7
7.8
9
*
Z2446
NOMESCO Finland
Social worker
3.6
7.7
26
78
M10.9
ICD-10 Finland
Gout, unspecified
3.7
7.5
25
74
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.4
7.4
28
90
M10
ICD-10 Finland
Gout
4.4
7.4
19
46
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
11.4
7.4
13
12
C09CA01
ATC
losartan; oral
2.3
7.4
73
390
7151
FHL
Kidney transplantation
+∞
7.3
7
*
KAC00
NOMESCO Finland
Nephrectomy
+∞
7.3
7
*
N13.7
ICD-10 Finland
Vesicoureteral-reflux-associated uropathy
+∞
7.3
7
*
I12.9
ICD-10 Finland
Hypertensive renal disease without renal failure
+∞
7.3
7
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.3
7.3
30
102
N28.9
ICD-10 Finland
Disorder of kidney and ureter, unspecified
31.1
7.2
9
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.3
7.2
71
378
I10
ICD-10 Finland
Essential (primary) hypertension
2.3
7.2
149
1067
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.6
7.1
17
39
M01AH05
ATC
etoricoxib; oral
0.4
7.1
57
987
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
11.5
6.9
12
11
I50.9
ICD-10 Finland
Heart failure, unspecified
2.5
6.9
49
225
KH1BT
NOMESCO Finland
Urinary tract cathetrisation with X-ray guidance
17.4
6.8
10
6
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
41.4
6.8
8
*
XPX08
NOMESCO Finland
Intraoperative flow measurement
23.4
6.7
9
*
C07AG02
ATC
carvedilol; oral
3.4
6.7
25
80
K65.0
ICD-10 Finland
Acute peritonitis
10.5
6.6
12
12
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.5
6.6
45
202
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
71.9
6.5
7
*
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
71.9
6.5
7
*
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
71.9
6.5
7
*
N13.0
ICD-10 Finland
Hydronephrosis with ureteropelvic junction obstruction
71.9
6.5
7
*
C08CA13
ATC
lercanidipine; oral
2.5
6.4
45
204
I15.9
ICD-10 Finland
Secondary hypertension, unspecified
18.7
6.3
9
5
H05BX02
ATC
paricalcitol; systemic
+∞
6.3
6
*
Q60.0
ICD-10 Finland
Renal agenesis, unilateral
+∞
6.3
6
*
KA3EB
NOMESCO Finland
Antegrade pyelography
+∞
6.3
6
*
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
27.5
6.3
8
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.5
6.2
22
68
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
6.2
83
495
J01MA06
ATC
norfloxacin; oral
2.7
6.1
35
144
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
6.0
85
515
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
122
255
9.59
64.25
21.5
5.3
1.18
1.05
mmol/l
3.89
122
235
91
141
10.36
61.73
9.4
3.4
163.56
76.26
ng/l
4.43
81
122
41
32
15.55
43.82
11.5
2.7
17.69
9.93
pmol/l
1.27
41
32
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
36
44
9.60
28.22
3.4
2.5
0.29
0.40
iu/ml
0.60
20
23
35
43
9.51
27.30
11.7
7.1
1181.14
147.57
iu/ml
—
7
7
40
60
7.94
26.49
8.0
2.4
22.67
25.29
mmol/l
2.59
40
60
38
58
7.72
24.72
7.7
4.5
8.87
8.53
kpa
0.50
38
58
54
120
5.65
24.23
9.1
4.3
0.65
1.60
mmol/l
0.84
35
91
166
928
4.31
20.34
26.7
7.2
1.20
1.21
mmol/l
1.67
145
820
155
847
3.87
19.17
22.8
6.0
1.21
1.21
mmol/l
0.23
149
786
51
134
4.66
18.52
6.5
3.0
32.97
62.49
ml/min/173m2
9.54
36
57
63
200
4.02
17.76
9.9
3.7
0.45
1.80
mmol/l
2.25
51
163
25
35
7.94
17.33
2.2
1.3
—
—
—
0
0
24
32
8.30
17.32
2.3
1.3
174.64
156.14
au/ml
—
11
10
56
169
4.11
16.86
5.2
3.3
—
—
—
0
0
110
527
3.19
15.97
9.7
3.3
0.15
0.37
e6/l
2.95
95
394
122
624
3.17
15.75
9.6
4.2
33.25
10.61
mg/mmol
1.82
98
401
120
613
3.13
15.44
11.6
3.4
46.93
142.00
e6/l
0.43
110
475
39
96
4.73
15.20
2.2
2.3
1.60
1.42
g/l
0.55
34
86
30
59
5.74
15.06
2.3
3.9
77.95
66.08
mg/l
0.15
22
50
30
59
5.74
15.06
2.3
3.9
42.86
28.54
mg/l
0.70
22
50
122
639
3.06
14.85
7.9
3.4
5.80
8.17
mmol/l
7.43
110
541
61
217
3.51
14.26
6.7
8.0
0.11
0.88
mmol/l
0.66
43
185
28
55
5.69
14.05
2.3
3.8
2.19
3.78
ratio
0.48
16
31
60
219
3.40
13.40
6.8
7.9
11.37
12.01
kpa
0.54
55
212
22
36
6.68
13.21
2.0
1.1
233.91
222.52
u/ml
0.04
15
21
22
38
6.33
12.53
2.0
1.2
—
—
—
0
0
96
479
2.79
12.19
4.0
2.2
3.23
2.96
mg/l
0.46
91
422
43
136
3.69
11.87
2.0
1.6
—
—
—
0
0
15
6
26.67
11.30
1.1
1.0
—
—
—
0
0
112
625
2.63
11.13
7.8
3.4
2.35
2.36
mmol/l
0.48
107
564
133
818
2.61
10.64
8.8
2.9
218.99
128.02
ug/l
3.33
127
758
131
802
2.59
10.55
4.4
2.4
77.49
76.88
nmol/l
0.08
123
712
65
301
2.65
9.16
6.9
3.0
1.26
2.84
e6/l
1.43
38
154
165
1173
2.67
9.06
10.5
4.6
2259.14
1027.32
e6/l
—
7
22
66
310
2.62
9.02
2.5
1.6
1626.31
1205.12
nmol/l
1.77
55
239
65
305
2.61
8.89
4.8
1.9
29.06
28.86
s
0.09
65
294
68
327
2.57
8.84
2.6
2.0
—
—
—
0
0
60
273
2.65
8.71
12.4
6.9
103.33
103.97
mmol/l
0.41
60
273
96
548
2.34
8.50
10.6
4.0
0.00
0.01
estimate
0.50
44
179
89
504
2.29
7.91
6.8
2.9
414.54
348.60
umol/l
8.08
81
441
64
327
2.35
7.12
5.4
2.9
0.77
1.06
e6/l
0.53
36
179
123
821
2.14
7.02
4.9
2.9
—
—
estimate
—
0
0
11
8
14.39
6.97
1.5
1.1
125.00
174.33
mmol/24h
—
11
8
139
976
2.17
6.91
9.9
3.9
0.00
0.00
estimate
-0.00
50
196
34
130
2.91
6.78
8.1
3.3
113.56
129.98
g/l
2.98
34
125
139
989
2.12
6.51
10.0
4.0
0.00
7.96
estimate
0.50
52
204
20
56
3.83
6.48
1.5
1.3
—
—
—
0
0
19
52
3.91
6.35
1.4
1.9
—
—
—
0
0
89
541
2.09
6.33
9.2
3.4
0.00
0.00
estimate
-0.00
43
161
15
24
6.63
6.28
1.2
1.4
—
—
—
0
0
6
0
+∞
6.28
21.5
0.0
198.17
—
e6/l
—
6
0
6
0
+∞
6.28
1.7
0.0
—
—
—
0
0
139
997
2.09
6.27
10.1
4.0
0.00
0.00
estimate
-0.00
50
191
15
25
6.36
6.12
1.1
1.1
—
—
—
0
0
76
440
2.12
6.11
4.6
2.5
—
—
—
0
0
19
55
3.69
5.88
3.7
1.3
—
—
—
0
0
110
748
1.95
5.52
9.9
3.9
0.00
0.02
estimate
0.50
42
162
12
17
7.40
5.52
2.8
1.3
1553.25
599.24
mg
0.97
12
17
31
126
2.70
5.50
10.0
9.6
0.78
0.67
%
0.98
31
126
47
236
2.26
5.32
2.1
2.0
—
—
—
0
0
5
0
+∞
5.23
10.0
0.0
—
—
—
0
0
8
6
13.77
5.12
1.0
1.0
1189.13
1052.00
miu/ml
—
8
6
48
248
2.20
5.06
2.1
1.9
—
—
—
0
0
31
132
2.57
5.02
10.0
9.1
1.31
1.34
%
0.07
31
132
171
1387
2.08
4.76
18.1
8.4
95.42
80.94
u/l
2.20
166
1304
141
1073
1.89
4.73
14.9
10.4
4.71
4.08
e9/l
2.41
124
942
91
606
1.86
4.66
3.6
3.5
6790.56
1236.49
ng/l
2.31
79
507
24
100
2.57
4.06
2.0
1.4
—
—
—
0
0
8
13
6.34
3.53
1.1
1.5
—
—
—
0
0
7
10
7.19
3.39
1.1
1.3
163.57
84.61
u/l
—
7
10
7
10
7.19
3.39
1.1
1.3
73.71
19.37
u/l
—
7
10
7
11
6.53
3.21
1.0
1.4
67.00
108.55
pmol/l
—
7
11
58
374
1.75
3.12
2.0
1.8
433.73
441.92
pmol/l
0.09
51
321
20
87
2.43
3.11
2.5
2.4
40.41
39.87
u/l
0.04
20
78
11
31
3.68
3.04
3.3
1.8
—
—
—
0
0
5
5
10.19
2.99
1.2
1.4
—
—
—
0
0
15
59
2.66
2.85
2.6
1.2
—
—
—
0
0
21
99
2.24
2.75
4.1
3.4
4.14
4.44
pmol/l
0.72
21
85
7
14
5.13
2.75
7.9
1.9
—
—
—
0
0
7
14
5.13
2.75
1.0
2.3
—
—
—
0
0
9
24
3.86
2.70
1.1
1.5
—
—
—
0
0
15
61
2.57
2.68
4.3
3.3
4.22
4.06
mmol/l
0.36
15
61
9
25
3.71
2.60
1.1
1.4
—
—
—
0
0
73
524
1.59
2.56
2.0
1.6
18.62
21.10
nmol/l
0.77
64
435
97
751
1.53
2.41
5.7
4.1
59.48
43.40
ng/l
0.52
84
546
5
8
6.36
2.38
1.0
1.9
—
—
—
0
0
5
8
6.36
2.38
1.0
1.8
—
—
—
0
0
11
40
2.84
2.31
1.5
1.2
—
—
—
0
0
13
54
2.50
2.24
1.5
1.5
—
—
—
0
0
13
54
2.50
2.24
3.3
1.6
—
—
—
0
0
5
9
5.65
2.22
1.4
3.4
906.00
632.11
u/ml
—
5
9
5
9
5.65
2.22
1.0
1.7
—
—
—
0
0
22
116
2.00
2.20
2.2
1.8
—
—
—
0
0
15
69
2.26
2.10
3.3
2.1
—
—
—
0
0
98
777
1.47
2.09
2.4
2.1
102.44
95.80
pmol/l
0.71
53
387
5
10
5.09
2.08
1.4
1.5
—
—
—
0
0
5
10
5.09
2.08
1.4
1.5
—
—
—
0
0
35
528
0.60
2.07
3.0
4.7
20.68
21.58
%
0.17
20
258
8
27
3.04
1.95
2.8
2.3
—
—
—
0
0
57
409
1.53
1.95
3.2
1.8
1.99
1.38
mg/l
0.79
46
324
24
394
0.56
1.94
2.3
3.1
0.80
0.77
ug/l
0.13
17
243
61
447
1.51
1.89
9.7
4.1
1.02
1.02
kg/l
0.86
51
290
14
66
2.20
1.86
1.6
1.8
—
—
—
0
0
8
30
2.73
1.74
1.6
1.8
—
—
—
0
0
5
13
3.91
1.72
1.4
1.5
—
—
—
0
0
5
13
3.91
1.72
1.0
1.1
—
—
—
0
0
5
13
3.91
1.72
1.4
1.5
—
—
—
0
0
190
1756
1.64
1.65
42.1
16.8
24.88
24.54
mg/l
0.06
174
1444
12
56
2.21
1.64
3.9
1.6
—
—
—
0
0
15
77
2.02
1.63
2.0
2.7
—
—
—
0
0
12
57
2.17
1.58
1.2
1.2
—
—
—
0
0
11
51
2.22
1.53
2.0
1.4
—
—
—
0
0
151
1342
1.41
1.52
6.1
4.5
21.18
11.89
mm/h
5.71
142
1238
6
21
2.91
1.51
1.8
1.7
—
—
—
0
0
9
38
2.43
1.47
1.4
1.6
—
—
—
0
0
6
22
2.77
1.44
1.8
1.6
—
—
—
0
0
6
22
2.77
1.44
1.8
1.6
—
—
—
0
0
6
22
2.77
1.44
1.8
1.6
—
—
—
0
0
6
23
2.65
1.37
1.8
1.6
—
—
—
0
0
6
23
2.65
1.37
1.8
1.6
—
—
—
0
0
5
17
2.98
1.36
2.8
4.6
18.72
53.35
u/ml
—
5
17
12
62
1.99
1.30
2.5
1.6
0.01
0.02
iu/ml
—
5
16
11
55
2.05
1.29
1.5
1.4
338.33
306.92
ug/g
—
6
33
5
18
2.82
1.29
1.8
1.4
—
—
—
0
0
5
18
2.82
1.29
1.8
1.3
190.20
247.79
u/l
—
5
18
8
35
2.33
1.28
2.3
1.4
—
—
—
0
0
8
35
2.33
1.28
2.3
1.4
—
—
—
0
0
6
25
2.44
1.25
1.0
1.7
—
—
—
0
0
8
37
2.21
1.23
1.6
1.7
—
—
—
0
0
5
19
2.67
1.22
7.4
2.4
0.80
0.79
index
—
5
19
8
38
2.15
1.19
1.0
1.3
—
—
—
0
0
5
21
2.41
1.09
3.4
3.5
—
—
—
0
0
11
61
1.85
1.00
1.9
1.4
—
—
—
0
0
9
49
1.87
1.00
1.6
1.6
—
—
—
0
0
28
203
1.44
0.93
4.3
4.5
9.03
29.85
ug/l
0.49
23
167
47
374
1.33
0.90
4.7
2.8
2.47
2.46
mmol/l
0.27
41
332
45
357
1.33
0.88
4.1
4.0
400.47
167.48
ng/l
0.53
36
286
8
45
1.81
0.85
1.5
1.4
—
—
—
0
0
27
199
1.41
0.83
15.5
7.7
—
—
—
0
0
23
166
1.43
0.79
2.0
2.2
—
—
—
0
0
7
41
1.73
0.70
1.0
1.6
—
—
—
0
0
7
44
1.61
0.65
1.3
1.2
—
56.10
—
0
5
17
121
1.44
0.64
1.2
1.2
380.46
540.41
u/ml
0.18
17
113
174
1658
1.25
0.61
41.0
16.4
53.21
80.46
ml/min/173m2
24.98
169
1539
8
55
1.47
0.56
1.4
1.3
—
—
—
0
0
8
55
1.47
0.56
1.4
1.3
—
—
—
0
0
81
726
1.18
0.55
2.0
2.0
1.53
1.39
mmol/l
0.63
68
602
116
1083
1.15
0.45
3.1
3.0
—
—
—
0
0
23
185
1.27
0.44
2.1
2.3
—
—
—
0
0
6
41
1.48
0.36
1.0
1.4
7.67
227.32
e6/l
—
6
31
188
1834
1.18
0.33
24.0
12.6
29.71
26.48
u/l
0.42
183
1787
6
83
0.72
0.24
3.7
2.1
—
—
—
0
0
13
157
0.82
0.23
1.2
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
11.7
—
42.00
—
0
5
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
168
1641
1.10
0.21
7.0
4.4
1.49
1.27
mmol/l
3.05
160
1510
0
12
0.00
0.21
0.0
1.2
—
9.83
—
0
12
164
1677
0.91
0.20
8.1
5.2
5.97
5.98
mmol/l
0.06
158
1533
31
341
0.89
0.19
1.6
1.6
—
—
—
0
0
6
53
1.14
0.19
1.2
1.2
—
14.90
—
0
7
11
91
1.22
0.18
3.7
2.3
—
—
—
0
0
5
66
0.75
0.17
1.4
1.1
0.94
0.93
g/l
—
5
66
27
297
0.90
0.16
1.2
1.3
2.26
8.76
u/ml
—
8
115
168
1651
1.08
0.14
10.0
6.7
39.57
39.61
mmol/mol
0.02
163
1556
13
114
1.15
0.12
1.6
2.6
—
12.62
—
0
9
44
464
0.94
0.11
1.4
1.3
0.93
1.88
u/ml
0.82
12
113
11
96
1.15
0.10
1.1
1.0
—
—
—
0
0
64
663
0.95
0.09
4.5
5.4
1.37
2.42
ug/l
1.42
58
595
5
65
0.76
0.08
2.0
1.7
—
—
—
0
0
31
325
0.95
0.06
1.2
1.3
17.52
34.39
iu/ml
—
10
101
24
228
1.06
0.05
1.7
1.5
—
—
—
0
0
11
101
1.09
0.04
1.0
1.3
—
38.17
—
0
9
12
111
1.09
0.04
1.6
1.3
69.11
152.20
u/ml
—
7
40
175
1743
1.02
0.01
8.2
6.0
2.36
2.67
mmol/l
5.08
165
1614
19
184
1.04
0.00
1.7
2.6
10.79
14.87
nmol/l
1.42
19
177
133
1336
0.99
0.00
5.6
4.2
14.90
14.78
pmol/l
0.23
127
1215
172
1715
1.01
0.00
7.8
5.3
4.27
4.58
mmol/l
3.83
164
1599
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
97
0.92
-0.00
1.3
1.3
—
—
—
0
0
171
1710
1.00
-0.00
7.7
5.2
1.36
1.44
mmol/l
2.14
162
1581
0
9
0.00
-0.00
0.0
1.2
—
9.78
—
0
9
6
65
0.92
-0.00
1.8
1.4
22.23
21.98
iu/l
—
6
55
160
1600
1.00
-0.00
6.2
5.2
1.86
1.98
mu/l
0.60
154
1471
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
66.44
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint N14_UNSPECKIDCONTR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_UNSPECKIDCONTR | 2.593 [2.02, 3.33] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.521 |
During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 605 females with N14_UNSPECKIDCONTR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_UNSPECKIDCONTR | 2.537 [1.95, 3.3] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 233 out of 572 males with N14_UNSPECKIDCONTR died.
Mortality risk
Mortality risk for people of age
years, who have N14_UNSPECKIDCONTR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.242% | 0.652% |
| 5 | 1.628% | 3.302% |
| 10 | 4.228% | 8.142% |
| 15 | 7.901% | 14.549% |
| 20 | 13.33% | 24.081% |
Relationships between endpoints
↥Index endpoint: N14_UNSPECKIDCONTR – Unspecified contracted kidney
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data