Acquired atrophy of ovary and fallopian tube

N14_ATROPHOV

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

only females

313377

2. Check conditions

None

313377

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N83.3
  • Cause of death: ICD-10 N83.3

2 out of 7 registries used, show all original rules.

114

4. Check minimum number of events

None

114

5. Include endpoints

None

114

6. Filter based on genotype QC (FinnGen only)

105

Control definitions (FinnGen only)

Control exclude
N14_FEMALEGENNONINF

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N83
Name in latin
Atrophia acquisita ovarii et tubae uterinae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 567 567 -
Only index persons 554 554 -
Unadjusted period prevalence (%)
Whole population 0.02 0.02 -
Only index persons 0.02 0.02 -
Median age at first event (years)
Whole population - 41.06 -
Only index persons - 40.51 -

-FinnGen-

Key figures

All Female Male
Number of individuals 105 105 -
Unadjusted period prevalence (%) 0.04 0.04 -
Median age at first event (years) 41.21 41.21 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
107
Matched controls
1070
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N83.3
ICD-10 Finland
Acquired atrophy of ovary and fallopian tube
+∞
154.3
107
*
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
141.7
51.8
52
7
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
10.5
34.0
70
163
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
+∞
25.0
23
*
N95.1
ICD-10 Finland
Menopausal and female climacteric states
+∞
25.0
23
*
N80.1
ICD-10 Finland
Endometriosis of ovary
107.1
17.1
18
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
5.3
16.3
52
163
JAL21
NOMESCO Finland
Laparoscopic excision or destruction of lesion of peritoneum
+∞
13.8
13
*
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
12.2
13.7
25
26
LCA06
NOMESCO Finland
Biopsy of endometrium
12.4
12.8
23
23
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
6.7
12.7
23
42
N80.9
ICD-10 Finland
Endometriosis, unspecified
146.5
12.7
13
*
N84.0
ICD-10 Finland
Polyp of corpus uteri
+∞
11.7
11
*
N80.0
ICD-10 Finland
Endometriosis of uterus
+∞
11.7
11
*
UJF32
NOMESCO Finland
Coloscopy
4.4
11.7
40
128
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.7
10.2
61
282
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
22.7
10.1
14
7
N97.9
ICD-10 Finland
Female infertility, unspecified
29.2
10.1
13
5
LAC01
NOMESCO Finland
Laparoscopic excision of ovarian cyst
60.6
9.8
11
*
SPAT1254
SPAT
Administration of medicine
5.0
9.0
22
53
N83.1
ICD-10 Finland
Corpus luteum cyst
97.4
8.5
9
*
LBF01
NOMESCO Finland
Laparoscopic perfusion of Fallopian tube
+∞
8.4
8
*
N83.8
ICD-10 Finland
Other noninflammatory disorders of ovary, fallopian tube and broad ligament
+∞
8.4
8
*
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
5.0
8.4
20
47
J02AC01
ATC
fluconazole; systemic
3.3
8.2
69
378
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
3.4
8.1
73
416
N95.0
ICD-10 Finland
Postmenopausal bleeding
20.2
7.8
11
6
N81.6
ICD-10 Finland
Rectocele
85.8
7.5
8
*
ULC02
NOMESCO Finland
Hysteroscopy
17.3
7.4
11
7
N95.2
ICD-10 Finland
Postmenopausal atrophic vaginitis
+∞
7.4
7
*
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
9.9
7.3
14
16
JAH01
NOMESCO Finland
Laparoscopy
9.9
7.3
14
16
N83.0
ICD-10 Finland
Follicular cyst of ovary
32.4
7.3
9
*
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
9.3
7.1
14
17
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.1
6.9
39
167
JAP01
NOMESCO Finland
Laparoscopic freeing of adhesions in the peritoneal cavity
42.9
6.9
8
*
N81.2
ICD-10 Finland
Incomplete uterovaginal prolapse
42.9
6.9
8
*
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
8.3
6.7
14
19
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
74.1
6.5
7
*
L02AE02
ATC
leuprorelin; implant, parenteral
19.4
6.4
9
5
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
4.0
6.4
20
58
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
8.5
6.3
13
17
N97.8
ICD-10 Finland
Female infertility of other origin
+∞
6.3
6
*
N80.5
ICD-10 Finland
Endometriosis of intestine
+∞
6.3
6
*
TLW12
NOMESCO Finland
Insertion of frozen embryo
+∞
6.3
6
*
N81.1
ICD-10 Finland
Cystocele
+∞
6.3
6
*
LC2HE
NOMESCO Finland
Hystero-salpingography with ultrasound
16.2
6.0
9
6

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
49
265
2.57
5.32
3.9
2.7
—
—
—
0
0
11
16
7.52
5.10
1.7
1.3
53.09
87.94
pmol/l
0.43
11
16
59
373
2.30
4.28
2.1
1.8
—
—
—
0
0
56
357
2.19
3.86
10.6
10.4
1.21
1.13
inr
0.55
45
292
52
344
2.00
3.06
5.4
3.0
0.27
0.03
estimate
0.40
11
69
45
283
2.02
3.05
3.5
3.2
60.39
21.88
ng/l
0.35
22
176
66
476
2.01
3.02
5.5
3.2
0.00
0.00
estimate
-0.00
14
88
66
477
2.00
2.99
5.5
3.2
0.00
16.92
estimate
0.50
13
96
65
468
1.99
2.97
5.6
3.2
0.00
0.00
estimate
-0.00
12
89
35
206
2.04
2.81
6.1
2.8
1.02
1.02
kg/l
0.45
29
131
10
32
3.34
2.51
6.1
7.6
—
—
—
0
0
63
466
1.86
2.48
6.2
6.5
9.16
9.41
umol/l
0.12
63
447
18
85
2.34
2.46
1.2
1.4
—
—
—
0
0
32
191
1.96
2.43
1.4
1.3
3.65
12.42
u/ml
1.11
13
77
69
529
1.86
2.38
6.5
10.4
4.31
4.14
e9/l
0.29
64
467
58
422
1.82
2.37
6.4
6.8
1.21
1.22
mmol/l
0.09
51
371
38
244
1.86
2.32
3.9
2.9
0.00
0.01
estimate
—
10
75
42
281
1.81
2.23
2.5
2.1
—
—
—
0
0
53
381
1.77
2.21
5.5
2.7
6.34
6.28
ph
0.16
35
208
34
216
1.84
2.12
1.4
1.3
7.82
29.74
iu/ml
2.03
14
59
17
85
2.19
2.04
1.9
1.5
—
—
—
0
0
99
892
2.47
1.93
6.7
5.5
1.63
1.88
mu/l
2.02
93
836
22
125
1.96
1.90
1.2
1.2
—
—
—
0
0
31
200
1.77
1.82
2.0
1.8
1.45
1.05
mg/l
0.52
22
152
42
296
1.69
1.80
6.0
6.2
—
—
—
0
0
8
30
2.80
1.76
2.9
2.1
27.63
24.61
mmol/l
—
8
30
10
40
2.65
1.72
2.6
2.3
—
—
—
0
0
56
430
1.63
1.70
3.1
2.4
—
—
estimate
—
0
0
45
327
1.65
1.70
3.7
3.4
94.47
64.22
e6/l
0.14
37
213
6
22
2.83
1.45
1.3
1.1
—
—
—
0
0
6
22
2.83
1.45
8.2
4.5
37.00
36.94
°c
—
6
22
96
869
2.02
1.39
5.0
4.4
5.86
5.85
mmol/l
0.02
89
813
100
927
2.20
1.33
5.0
4.5
4.91
4.94
mmol/l
0.11
94
872
36
263
1.56
1.28
6.3
3.2
0.00
0.00
estimate
-0.00
13
91
8
36
2.32
1.27
3.6
2.3
0.61
0.56
%
—
8
36
8
37
2.25
1.24
3.6
2.4
1.37
1.14
%
—
8
37
52
415
1.49
1.22
1.9
1.8
1.44
1.32
mmol/l
0.49
44
360
33
239
1.55
1.21
1.2
1.3
0.50
2.20
u/ml
—
8
66
30
213
1.57
1.20
3.8
4.0
—
—
—
0
0
93
844
1.78
1.18
5.7
5.4
37.71
38.68
mmol/mol
0.68
85
804
0
33
0.00
1.18
0.0
1.6
—
1.32
—
0
23
0
34
0.00
1.18
0.0
1.6
—
—
—
0
0
0
35
0.00
1.17
0.0
1.6
—
—
—
0
0
10
51
2.06
1.15
2.4
3.9
77.10
224.68
ng/l
—
10
46
13
74
1.86
1.12
3.0
3.3
6.02
5.94
kpa
0.10
13
74
5
21
2.45
1.10
1.0
1.0
—
—
—
0
0
10
52
2.02
1.10
7.2
3.0
—
—
—
0
0
20
288
0.62
1.08
1.7
1.5
—
—
—
0
0
12
68
1.86
1.05
7.4
9.1
—
—
—
0
0
16
100
1.71
1.04
8.4
7.9
103.88
104.46
mmol/l
0.16
16
100
99
926
1.92
1.02
4.9
4.4
1.60
1.59
mmol/l
0.06
91
869
7
35
2.07
1.02
14.0
9.4
26.29
24.77
mmol/l
—
7
35
7
37
1.95
0.96
1.1
1.1
—
—
—
0
0
88
804
1.53
0.89
19.3
16.9
13.49
13.52
%
0.08
88
792
8
47
1.76
0.83
14.0
10.7
0.69
0.57
%
—
8
47
8
47
1.76
0.83
14.1
10.8
91.61
94.61
%
—
8
47
8
48
1.72
0.80
1.1
2.0
—
—
—
0
0
17
116
1.55
0.80
1.1
1.3
—
—
—
0
0
99
937
1.76
0.80
5.7
5.1
2.85
2.91
mmol/l
0.31
91
881
5
24
2.13
0.75
1.2
1.1
557.40
501.42
mg/l
—
5
24
10
60
1.74
0.75
3.1
2.5
7.48
4.28
kpa
—
10
60
5
25
2.05
0.73
4.8
9.3
0.88
0.82
%
—
5
25
27
208
1.40
0.72
1.4
1.5
2.14
2.25
g/l
0.13
16
125
11
69
1.66
0.71
10.1
10.9
120.00
117.64
g/l
0.16
11
69
12
78
1.61
0.69
2.3
2.8
4.45
4.67
pmol/l
0.39
12
69
7
43
1.67
0.68
2.3
1.3
1.21
1.18
g/l
—
7
38
8
49
1.68
0.64
14.1
10.4
1.78
1.20
%
—
8
49
15
106
1.48
0.62
2.3
5.0
1.01
1.04
mmol/l
0.19
15
99
10
64
1.62
0.61
1.4
1.3
—
—
—
0
0
43
365
1.30
0.60
2.4
2.2
94.10
92.86
pmol/l
0.06
18
179
16
116
1.45
0.58
1.4
1.7
—
—
—
0
0
92
868
1.43
0.57
4.1
3.8
1.25
1.22
mmol/l
0.20
84
811
11
75
1.52
0.53
1.4
1.2
—
—
—
0
0
16
119
1.41
0.52
1.5
1.4
—
—
—
0
0
7
46
1.56
0.49
2.6
4.0
25.36
25.45
mmol/l
—
7
46
15
113
1.38
0.45
2.1
1.4
—
—
—
0
0
36
309
1.25
0.45
4.7
6.7
—
—
—
0
0
8
55
1.49
0.44
4.5
7.3
25.39
25.22
mmol/l
—
8
55
27
225
1.27
0.43
2.6
4.9
—
—
—
0
0
0
15
0.00
0.41
0.0
3.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
12
89
1.39
0.40
1.2
2.2
326.00
346.24
nmol/l
0.15
12
83
10
72
1.43
0.38
1.6
1.3
—
—
—
0
0
6
41
1.49
0.37
15.7
11.3
16.93
15.27
%
—
6
41
46
419
1.17
0.30
8.5
9.5
0.00
0.00
e9/l
0.62
39
339
14
113
1.27
0.28
1.8
1.9
—
—
—
0
0
14
114
1.26
0.26
1.3
3.7
3.89
5.13
e9/l
0.78
14
106
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
4.1
—
25.04
—
0
5
0
12
0.00
0.21
0.0
12.7
—
879.75
—
0
12
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
23
205
1.16
0.19
2.0
1.9
—
—
—
0
0
84
814
1.15
0.18
25.0
17.1
331.15
330.55
g/l
0.26
84
809
17
148
1.18
0.18
4.5
2.4
2.48
2.45
mmol/l
0.44
17
134
7
62
1.14
0.17
2.1
3.6
1.21
1.24
mmol/l
—
7
53
8
70
1.15
0.17
5.4
3.3
—
—
—
0
0
30
276
1.12
0.16
3.4
4.1
1.12
7.04
mg/mmol
1.53
21
163
37
395
0.90
0.15
3.2
2.9
—
—
—
0
0
29
271
1.10
0.11
2.9
3.5
6.62
27.44
mg/l
2.03
18
166
5
46
1.09
0.10
1.6
1.3
0.85
0.92
g/l
—
5
46
6
58
1.04
0.08
1.3
3.9
65.40
68.32
g/l
—
6
53
10
88
1.15
0.08
1.3
1.5
—
—
—
0
0
14
127
1.12
0.08
1.6
2.4
14.31
13.53
umol/l
0.12
14
120
13
118
1.12
0.07
1.7
2.4
2.59
2.38
g/l
0.60
13
112
11
100
1.11
0.05
1.5
1.3
—
—
—
0
0
11
119
0.92
0.04
1.8
1.8
—
—
—
0
0
13
127
1.03
0.00
1.2
1.4
—
—
—
0
0
18
184
0.97
0.00
1.8
1.6
—
—
—
0
0
5
52
0.96
0.00
1.4
4.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
222.00
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
32.78
—
0
9
8
82
0.97
-0.00
1.5
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
11.80
—
0
5
0
7
0.00
-0.00
0.0
1.9
—
44.86
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
-0.00
1.2
1.2
—
39.86
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
409.20
—
0
5
5
57
0.87
-0.00
1.4
1.1
—
—
—
0
0
5
51
0.98
-0.00
1.6
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
10.5
—
0.62
—
0
6
0
9
0.00
-0.00
0.0
1.0
—
13.13
—
0
9
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.6
—
10.42
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
92.00
—
0
5
0
6
0.00
-0.00
0.0
5.0
—
7.40
—
0
6

Mortality – FinRegistry

Association

Association between endpoint N14_ATROPHOV and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_ATROPHOV.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: N14_ATROPHOV – Acquired atrophy of ovary and fallopian tube

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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