Polyarteritis Nodosa: ['A necrotizing vasculitis that affects medium-sized arteries, it is usually idiopathic, and may be triggered by viral infections (Hepatitis B, also others). A multisystem disease, it most commonly affects skin (nodules, livedo reticularis) and peripheral nerves; higher morbidity is associated with gastrointestinal, central nervous system, cardiac, and/or other organ involvement. Anti-neutrophil cytoplasmic antibodies (ANCA) are typically negative. [ NCI ]']
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
282 |
4. Check minimum number of eventsNone |
282 |
5. Include endpointsNone |
282 |
6. Filter based on genotype QC (FinnGen only) |
252 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M30
- Name in latin
- Polyarteritis nodosa
Similar endpoints
↥List of similar endpoints to
Polyarteritis nodosa
based on the number of shared cases.
Similar with more cases:
- Polyarteritis nodosa and related conditions
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2412 | 1441 | 939 |
| Only index persons | 1633 | 982 | 651 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.03 | 0.04 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 66.80 | 70.69 | 60.69 |
| Only index persons | 61.28 | 64.65 | 56.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 252 | 144 | 108 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 60.20 | 59.61 | 60.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 260
- Matched controls
- 2600
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M30.0
ICD-10 Finland
Polyarteritis nodosa
+∞
261.8
205
*
L04AX01
ATC
azathioprine; systemic
22.8
84.6
67
39
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
11.3
72.2
94
124
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
38.5
36
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
8.0
35.5
54
82
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
9.5
33.5
43
53
L04AA06
ATC
mycophenolic acid; systemic
38.9
29.6
37
11
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.1
27.9
150
652
M05BA04
ATC
alendronic acid; oral
5.6
27.7
62
138
H02AB06
ATC
prednisolone; systemic
4.2
27.0
177
874
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
26.5
25
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.4
26.5
62
143
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
6.8
25.4
44
76
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.6
24.0
69
188
L04AX03
ATC
methotrexate; systemic
5.6
23.9
52
112
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.8
23.8
65
170
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
83.9
21.0
23
*
M30.8
ICD-10 Finland
Other conditions related to polyarteritis nodosa
+∞
20.1
19
*
P01BA02
ATC
hydroxychloroquine; oral
5.5
19.5
41
85
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
19.0
18
*
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
19.0
18
*
C03CA01
ATC
furosemide; systemic
3.0
17.4
135
682
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
21.1
17.2
25
13
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
21.1
17.2
25
13
L01AA01
ATC
cyclophosphamide; systemic
68.0
17.0
19
*
F02.89*M30.0
ICD-10 Finland
Dementia in polyarteritis nodosa
+∞
16.8
16
*
4460A
ICD-9 Finland
Polyarteritis nodosa and allied conditions, Polyarteritis nodosa[POLYARTERITIS NODOSA (CLASSICA)]
+∞
16.8
16
*
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
16.8
16
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
32.4
16.4
21
7
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
15.8
15
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
6.4
15.6
27
46
H02AB04
ATC
methylprednisolone; systemic
3.6
15.4
61
205
N03AX16
ATC
[U] pregabalin
3.1
15.2
86
359
A11CC03
ATC
alfacalcidol; systemic
14.4
15.0
25
19
Z94.0
ICD-10 Finland
Kidney transplant status
85.0
14.7
16
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
+∞
14.7
14
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
5.6
14.5
29
57
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
14.1
155
910
A12AA04
ATC
calcium carbonate; oral
25.5
14.0
19
8
J01MA12
ATC
levofloxacin; systemic
3.1
13.8
74
298
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
13.7
13
*
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
13.7
13
*
44600
ICD-8 Finland
Polyarteritis nodosa and allied conditions, Polyarteritis nodosa
+∞
13.7
13
*
A10AC01
ATC
insulin (human); parenteral
3.9
13.6
44
128
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
22.6
13.5
19
9
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
6.8
13.5
22
35
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.2
13.4
39
105
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.1
12.9
29
63
N085, M318,
ICD-10 Finland
+∞
12.6
12
*
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
+∞
12.6
12
*
R50.9
ICD-10 Finland
Fever, unspecified
3.2
12.5
60
225
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.8
12.5
30
69
TK800
NOMESCO Finland
Hemodialysis
13.3
12.4
21
17
H02AB07
ATC
prednisone; oral
3.3
12.2
54
193
127
Kela drug reimbursment
Transplant complication
22.6
12.2
17
8
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.4
12.1
32
80
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
125.3
11.5
12
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.5
11.0
22
43
S97
ICPC
Chronic ulcer skin
3.8
10.9
35
101
A02BC01
ATC
omeprazole; systemic
2.5
10.9
95
485
D64.9
ICD-10 Finland
Anaemia, unspecified
3.2
10.7
48
172
D69.0
ICD-10 Finland
Allergic purpura
62.6
10.7
12
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
10.5
67
292
L04AD01
ATC
ciclosporin; systemic
12.8
10.5
18
15
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
10.5
10
*
M30.3
ICD-10 Finland
Mucocutaneous lymph node syndrome [Kawasaki]
+∞
10.5
10
*
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
+∞
10.5
10
*
N30.0
ICD-10 Finland
Acute cystitis
2.8
10.2
60
251
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.5
10.2
26
63
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
10.1
96
507
J01MA02
ATC
ciprofloxacin; systemic
2.3
9.7
123
731
J01FF01
ATC
clindamycin; systemic
2.4
9.7
89
460
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
57.2
9.7
11
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
9.6
97
523
I77.6
ICD-10 Finland
Arteritis, unspecified
103.7
9.5
10
*
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
9.4
9
*
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
9.4
9
*
ZX120
NOMESCO Finland
Intravenous
3.2
9.3
39
134
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
4.1
9.0
26
69
N18.0
ICD-10 Finland
End-stage renal disease
19.5
9.0
13
7
B03XA02
ATC
darbepoetin alfa; parenteral
11.3
8.9
16
15
137
Kela drug reimbursment
Uraemia requiring dialysis
51.8
8.7
10
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.4
8.6
22
53
ZXD05
NOMESCO Finland
Urgent procedure
2.3
8.6
94
521
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.6
8.6
21
49
Z49.0
ICD-10 Finland
Preparatory care for dialysis
28.6
8.5
11
*
A12BA01
ATC
potassium chloride; oral
3.7
8.5
28
82
Z2446
NOMESCO Finland
Social worker
3.7
8.5
28
82
A12AA12
ATC
[U] calcium acetate
92.9
8.5
9
*
M13.9
ICD-10 Finland
Arthritis, unspecified
3.7
8.3
28
83
TQW80
NOMESCO Finland
Local dermatologic skincare
8.6
8.2
17
21
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
17.9
8.2
12
7
A46
ICD-10 Finland
Erysipelas
2.6
8.1
53
232
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.8
7.8
24
67
TK810
NOMESCO Finland
Hemofiltration
46.4
7.8
9
*
WX892
NOMESCO Finland
Monitored bed care
3.3
7.7
30
98
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.3
7.7
30
98
M35.3
ICD-10 Finland
Polymyalgia rheumatica
8.4
7.7
16
20
L04AA01
ATC
[U] ciclosporin
12.4
7.7
13
11
C08CA01
ATC
amlodipine; oral
2.1
7.7
120
758
L04AD02
ATC
tacrolimus; systemic
25.9
7.6
10
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
7.6
57
266
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.1
7.5
34
122
JN6JR
NOMESCO Finland
Extensive PET-CT of whole body metabolism (crown to foot)
82.3
7.5
8
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
82.3
7.5
8
*
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.4
7.4
19
46
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
7.4
67
340
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.5
7.4
53
242
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
7.3
7
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
20.7
7.2
10
5
JN6DR
NOMESCO Finland
PET-CT of whole body metabolism
20.7
7.2
10
5
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
7.2
75
404
J01MA06
ATC
norfloxacin; oral
2.5
7.1
50
226
A10AB05
ATC
insulin aspart; parenteral
3.0
7.1
33
120
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
6.2
7.1
18
31
L52
ICD-10 Finland
Erythema nodosum
14.3
7.0
11
8
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.0
6.9
20
53
XW000
NOMESCO Finland
Bone marrow biopsy
4.3
6.9
18
44
TGC00
NOMESCO Finland
Bronchial lavation
6.0
6.9
18
32
L88
ICPC
Rheumatoid/seropositive arthritis
6.0
6.9
18
32
N18.8
ICD-10 Finland
Other chronic renal failure
7.5
6.8
15
21
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
41.2
6.8
8
*
N02AX02
ATC
tramadol; systemic, rectal
2.0
6.8
120
783
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
23.2
6.7
9
*
L01BA01
ATC
methotrexate; systemic
5.6
6.6
18
34
SPAT1255
SPAT
Intravenous administration of medicine
3.5
6.6
23
70
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
6.0
6.6
17
30
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
6.5
49
228
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
6.5
63
327
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
6.5
65
343
A41.9
ICD-10 Finland
Sepsis, unspecified
4.3
6.5
17
42
PAW37
NOMESCO Finland
Biopsy of temporal artery
71.5
6.5
7
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
14.8
6.4
10
7
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
18.6
6.3
9
5
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
6.3
6
*
L88
ICD-10 Finland
Pyoderma gangrenosum
+∞
6.3
6
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.8
6.2
32
123
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
4.3
6.2
16
39
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.8
6.2
33
130
R53
ICD-10 Finland
Malaise and fatigue
2.0
6.2
84
497
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
6.1
40
174
A02BC05
ATC
esomeprazole; systemic
1.9
6.1
115
759
JN4AD
NOMESCO Finland
Body CT examination
2.6
6.1
39
168
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.0
6.1
78
451
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.6
6.0
36
150
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
53
51
12.80
49.85
4.2
1.1
9.59
—
iu/ml
—
8
0
50
76
7.91
32.76
3.5
1.4
17.82
6.13
iu/ml
1.01
15
21
31
42
8.24
22.13
6.9
5.8
446.33
178.40
iu/ml
—
9
5
56
152
4.42
19.30
2.1
2.8
63.94
66.05
g/l
0.99
50
139
54
161
3.97
16.26
8.1
3.4
117.04
86.97
ng/l
0.99
47
140
26
41
6.93
16.15
1.2
1.3
—
—
—
0
0
39
100
4.41
14.29
1.7
2.0
1.46
1.48
g/l
0.04
34
89
28
54
5.69
14.25
2.4
4.6
2.65
4.40
ratio
0.44
16
25
28
56
5.48
13.70
1.7
1.5
0.20
0.04
iu/ml
—
6
9
29
60
5.31
13.68
2.4
4.7
54.55
167.54
mg/l
0.58
22
51
29
60
5.31
13.68
2.4
4.8
34.07
65.66
mg/l
0.43
22
52
25
47
5.78
13.05
1.5
1.3
1.60
3.28
u/ml
—
5
5
25
47
5.78
13.05
1.5
1.3
4.16
2.78
u/ml
—
5
6
33
83
4.41
12.34
1.3
2.3
33.68
38.93
u/l
0.85
28
74
21
35
6.44
12.33
1.4
1.2
—
—
—
0
0
164
1091
2.36
10.03
15.5
7.1
1.21
1.21
mmol/l
0.27
144
933
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
52
4.76
9.76
4.2
2.2
0.31
0.34
iu/ml
0.12
15
25
172
1190
2.32
9.28
18.3
9.6
4.80
4.17
e9/l
3.11
167
1045
21
32
7.04
8.86
1.4
1.2
271.67
198.80
u/ml
0.43
12
15
43
163
2.96
8.65
1.8
1.5
—
—
—
0
0
36
125
3.18
8.41
5.4
3.0
1.85
1.51
mmol/l
0.16
30
92
75
390
2.30
7.87
1.9
1.6
1307.54
1184.17
nmol/l
0.49
64
295
97
565
2.14
7.67
3.3
2.2
3.09
3.00
mg/l
0.13
89
488
17
26
6.92
7.24
1.4
1.1
9.00
1.33
u/ml
—
6
12
72
383
2.22
7.08
2.4
1.8
—
—
—
0
0
34
127
2.93
6.99
2.2
2.4
—
15.84
—
0
8
16
26
6.48
6.58
1.4
1.1
2.86
2.18
u/ml
—
7
11
13
16
8.49
6.41
1.0
1.1
—
—
—
0
0
33
128
2.81
6.33
9.2
3.5
23.94
23.92
mmol/l
0.02
33
128
107
684
1.96
6.31
3.6
2.1
327.28
226.75
u/l
0.24
102
648
101
637
1.96
6.17
6.0
3.1
0.33
0.47
e6/l
0.40
89
475
23
75
3.27
5.93
2.7
2.7
—
—
—
0
0
19
55
3.65
5.85
1.1
1.3
—
—
—
0
0
9
7
13.26
5.62
1.1
1.0
—
—
—
0
0
62
338
2.10
5.61
1.4
1.3
19.06
11.95
u/ml
0.25
26
120
13
21
6.46
5.46
1.9
3.6
1163.00
1049.00
mg
0.08
13
21
20
63
3.36
5.44
1.4
2.5
0.00
0.33
g/l
1.17
15
55
135
965
1.83
5.40
5.0
2.9
198.81
117.44
ug/l
2.61
128
896
65
367
2.03
5.34
1.5
1.3
31.97
29.54
iu/ml
0.07
24
123
17
49
3.64
5.27
1.4
1.4
—
—
—
0
0
5
0
+∞
5.22
3.4
0.0
—
—
—
0
0
45
226
2.20
4.99
8.5
3.5
5.88
5.66
kpa
1.09
45
218
76
473
1.86
4.62
2.0
1.8
0.94
1.56
mg/l
2.12
64
389
20
70
3.01
4.61
1.5
1.2
—
—
—
0
0
8
8
10.27
4.55
1.3
1.0
76.00
122.55
iu/ml
—
8
8
8
8
10.27
4.55
1.1
1.3
—
—
—
0
0
19
65
3.07
4.55
1.5
1.4
—
—
—
0
0
19
65
3.07
4.55
1.5
1.4
—
—
—
0
0
10
15
6.88
4.51
1.1
1.3
—
—
—
0
0
10
15
6.88
4.51
1.1
1.3
—
—
—
0
0
10
15
6.88
4.51
1.1
1.3
—
—
—
0
0
85
553
1.80
4.46
3.7
2.8
335.93
345.38
umol/l
0.29
74
478
51
282
2.01
4.39
2.4
1.8
—
—
—
0
0
10
16
6.45
4.33
1.1
1.3
—
—
—
0
0
10
16
6.45
4.33
2.2
1.6
—
—
—
0
0
49
271
2.00
4.21
2.4
1.8
—
—
—
0
0
147
1135
1.68
4.05
7.0
3.9
0.00
0.00
estimate
-0.00
38
254
101
707
1.70
4.03
7.7
4.1
23.08
9.36
mg/mmol
1.06
73
443
9
14
6.61
4.02
1.1
1.3
—
—
—
0
0
149
1158
1.67
3.97
6.9
4.0
0.00
0.00
estimate
-0.00
36
240
10
19
5.43
3.86
1.1
1.2
—
—
—
0
0
147
1145
1.65
3.83
7.0
4.0
0.00
6.22
estimate
0.50
38
261
96
673
1.68
3.76
3.1
2.6
48.11
62.68
u/l
1.34
89
632
42
229
1.99
3.74
3.6
3.4
—
—
—
0
0
18
67
2.81
3.74
1.4
1.3
—
—
—
0
0
107
779
1.63
3.58
4.3
3.3
2.30
2.36
mmol/l
2.78
102
698
8
13
6.31
3.53
2.4
2.6
—
—
—
0
0
20
82
2.56
3.48
2.1
1.8
—
—
—
0
0
19
76
2.62
3.46
1.9
1.7
—
—
—
0
0
99
712
1.63
3.46
4.4
3.2
34.84
34.48
u/l
0.02
93
674
16
60
2.78
3.29
1.5
1.4
—
—
—
0
0
8
15
5.46
3.21
3.1
2.7
87.00
96.47
%
—
8
15
8
16
5.12
3.07
1.5
1.8
—
—
—
0
0
8
16
5.12
3.07
1.5
1.8
—
—
—
0
0
8
16
5.12
3.07
1.5
1.8
—
—
—
0
0
6
8
7.64
3.07
1.5
2.1
1555.50
1092.00
u/ml
—
6
8
64
423
1.68
3.06
4.8
3.9
794.76
243.16
ng/l
0.63
55
350
15
57
2.73
3.02
1.7
1.4
—
—
—
0
0
171
1428
1.58
3.00
8.5
4.7
11196.11
2550.45
e6/l
—
9
33
12
37
3.35
2.97
1.4
1.4
—
—
—
0
0
12
37
3.35
2.97
2.6
3.1
4.95
4.97
kpa
0.04
12
37
90
652
1.58
2.97
6.9
4.0
0.00
0.01
estimate
0.50
37
230
13
46
2.92
2.96
1.6
1.4
—
—
—
0
0
158
1301
1.55
2.92
9.8
5.2
6.88
6.71
mmol/l
0.41
153
1226
7
13
5.50
2.89
1.1
1.5
—
—
—
0
0
7
13
5.50
2.89
1.1
1.5
—
—
—
0
0
97
722
1.55
2.82
4.0
3.3
3074.75
1565.16
ng/l
0.48
86
619
12
39
3.18
2.81
1.3
1.5
—
—
—
0
0
124
976
1.52
2.78
3.9
2.8
—
—
estimate
—
0
0
5
6
8.46
2.76
1.0
1.0
—
—
—
0
0
5
6
8.46
2.76
1.0
1.0
—
—
—
0
0
26
134
2.04
2.71
5.8
7.0
24.27
24.21
mmol/l
0.03
26
134
8
19
4.31
2.70
1.0
1.2
—
—
—
0
0
9
24
3.85
2.70
1.2
1.4
—
—
—
0
0
8
20
4.09
2.59
1.0
1.2
—
—
—
0
0
14
56
2.59
2.57
2.4
1.3
—
—
—
0
0
13
50
2.68
2.57
1.6
1.4
—
—
—
0
0
5
7
7.25
2.56
1.4
1.6
2.32
1.19
ratio
—
5
7
10
31
3.31
2.54
1.3
1.3
—
—
—
0
0
8
21
3.90
2.48
1.0
1.1
—
—
—
0
0
6
12
5.09
2.41
1.2
1.4
—
—
—
0
0
6
13
4.70
2.28
1.2
1.5
—
—
—
0
0
5
9
5.64
2.22
1.0
1.1
—
—
—
0
0
7
19
3.76
2.16
1.1
1.8
—
—
—
0
0
6
14
4.36
2.16
1.0
1.2
104.17
105.50
pmol/l
—
6
14
7
21
3.40
1.98
1.1
1.8
—
—
—
0
0
7
21
3.40
1.98
3.3
2.2
—
—
—
0
0
28
166
1.77
1.97
6.6
2.6
59.27
60.18
ml/min/173m2
0.04
15
71
119
975
1.41
1.97
2.6
2.1
92.83
93.51
pmol/l
0.06
77
500
52
363
1.54
1.96
5.4
2.9
1.38
2.29
e6/l
0.70
28
178
5
11
4.61
1.95
1.0
1.0
—
—
—
0
0
6
16
3.81
1.94
1.2
1.4
—
—
—
0
0
6
16
3.81
1.94
1.0
1.1
—
—
—
0
0
88
686
1.43
1.92
2.1
1.7
19.66
20.71
nmol/l
0.28
76
574
66
488
1.47
1.90
3.7
2.4
—
—
—
0
0
20
108
1.92
1.87
1.8
1.4
—
—
—
0
0
84
652
1.43
1.87
5.8
3.4
0.00
0.01
estimate
0.50
34
197
63
464
1.47
1.84
1.8
1.8
468.76
439.21
pmol/l
0.35
54
388
11
47
2.40
1.80
1.3
1.4
—
—
—
0
0
9
36
2.55
1.75
1.3
1.3
—
—
—
0
0
54
390
1.49
1.74
5.2
2.8
0.84
0.93
e6/l
0.08
30
203
110
904
1.38
1.73
7.1
4.1
39.08
39.96
ng/l
0.03
83
660
7
24
2.97
1.73
7.4
3.7
—
—
—
0
0
65
490
1.44
1.68
1.3
1.3
0.79
1.41
u/ml
0.72
15
132
14
69
2.09
1.68
2.1
1.4
—
—
—
0
0
6
19
3.21
1.67
1.2
1.4
—
—
—
0
0
5
14
3.62
1.62
1.2
1.1
85.00
71.43
umol/l
—
5
14
106
876
1.35
1.58
6.5
4.0
0.00
0.02
estimate
0.68
32
209
44
317
1.47
1.44
11.3
6.7
102.61
104.15
mmol/l
1.47
44
317
29
191
1.58
1.42
6.2
2.3
6.43
5.25
ug/l
0.21
24
172
9
42
2.18
1.35
1.6
1.2
—
—
—
0
0
9
42
2.18
1.35
1.6
1.2
—
—
—
0
0
11
199
0.53
1.23
2.2
1.9
3.80
3.56
ratio
—
6
165
5
23
2.20
0.98
1.0
1.5
—
—
—
0
0
5
23
2.20
0.98
1.0
1.5
—
—
—
0
0
6
27
2.25
0.94
1.2
1.3
—
—
—
0
0
10
56
1.82
0.89
1.7
1.5
—
—
—
0
0
6
31
1.96
0.85
1.0
1.1
—
—
—
0
0
6
32
1.90
0.82
1.3
1.1
—
—
—
0
0
154
1661
0.82
0.81
49.6
21.2
329.58
331.92
g/l
2.12
154
1653
31
400
0.74
0.79
2.5
3.2
0.58
0.77
ug/l
1.34
18
257
185
1957
0.81
0.78
5.6
5.2
5.94
6.02
mmol/l
0.33
169
1771
19
133
1.46
0.76
1.8
1.7
—
—
—
0
0
212
2020
1.27
0.75
40.3
16.3
25.11
24.23
mg/l
0.15
198
1670
5
24
2.10
0.75
1.0
1.5
—
—
—
0
0
5
24
2.10
0.75
1.0
1.5
—
—
—
0
0
5
24
2.10
0.75
1.0
1.5
—
—
—
0
0
5
24
2.10
0.75
1.0
1.5
—
—
—
0
0
12
180
0.65
0.70
1.7
2.1
—
—
—
0
0
7
41
1.73
0.70
7.9
3.0
15.33
10.37
pmol/l
—
7
41
30
233
1.33
0.68
4.4
4.4
14.18
53.98
ug/l
0.60
22
198
5
28
1.80
0.66
1.4
1.3
—
—
—
0
0
147
1365
1.18
0.62
4.1
3.2
61.57
48.94
u/l
0.94
139
1290
8
50
1.62
0.62
1.1
1.1
—
4.07
—
0
6
0
23
0.00
0.58
0.0
3.0
—
86.99
—
0
23
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
18
133
1.38
0.56
1.2
1.2
33.74
161.46
u/ml
—
9
47
39
323
1.24
0.56
1.8
1.5
—
—
—
0
0
10
140
0.70
0.44
1.6
1.8
3.72
3.55
mmol/l
—
5
103
23
185
1.27
0.43
1.4
1.4
—
—
—
0
0
15
194
0.76
0.42
1.6
2.2
—
—
—
0
0
196
2021
0.88
0.36
6.4
6.0
2.48
2.67
mmol/l
2.14
181
1858
90
836
1.12
0.34
2.2
2.0
1.55
1.34
mmol/l
0.82
79
691
191
1968
0.89
0.33
5.8
5.1
1.39
1.45
mmol/l
1.30
176
1805
29
250
1.18
0.31
10.4
7.3
—
—
—
0
0
7
56
1.26
0.29
2.1
1.4
—
—
—
0
0
54
494
1.12
0.27
8.4
4.3
1.02
1.02
kg/l
0.33
46
341
49
537
0.89
0.27
4.5
4.7
23.01
22.42
%
0.07
21
265
193
1973
0.92
0.22
5.7
5.2
4.37
4.58
mmol/l
1.91
179
1820
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
7.45
—
0
11
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
367.60
—
0
5
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
7
62
1.13
0.17
1.1
1.2
—
—
—
0
0
29
263
1.12
0.17
4.4
4.7
35.90
31.53
%
1.08
21
152
7
63
1.11
0.17
1.1
1.2
—
—
—
0
0
5
66
0.75
0.17
2.2
1.8
—
—
—
0
0
63
661
0.94
0.14
4.5
5.6
1.88
2.42
ug/l
0.61
58
595
186
1887
0.95
0.11
4.8
4.3
1.33
1.28
mmol/l
0.41
169
1713
11
96
1.15
0.10
1.0
1.0
—
—
—
0
0
117
1196
0.96
0.09
3.7
3.0
—
—
—
0
0
6
54
1.11
0.09
1.2
1.4
—
—
—
0
0
29
273
1.07
0.08
1.5
1.5
—
—
—
0
0
5
63
0.79
0.08
1.2
1.2
0.83
0.92
g/l
—
5
63
8
74
1.08
0.07
1.4
2.1
—
—
—
0
0
10
112
0.89
0.07
1.4
3.2
5.21
4.29
pmol/l
—
10
99
186
1878
0.97
0.06
5.6
5.4
2.06
1.93
mu/l
0.71
175
1705
158
1573
1.01
0.01
4.6
4.4
15.12
14.86
pmol/l
0.64
142
1415
195
1951
1.00
0.00
34.2
16.4
74.64
78.68
ml/min/173m2
1.49
187
1819
10
97
1.03
0.00
1.1
1.3
—
—
—
0
0
17
166
1.03
0.00
2.5
2.5
12.25
14.40
nmol/l
0.71
17
158
193
1927
1.01
0.00
8.2
6.6
40.44
39.74
mmol/mol
0.42
183
1791
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
77.20
—
0
5
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
5
54
0.92
0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
32.60
—
0
5
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
1.18
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.3
—
61.37
—
0
6
9
94
0.96
-0.00
1.7
2.1
—
—
—
0
0
7
70
1.00
-0.00
2.4
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_POLNODOSA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POLNODOSA | 2.456 [2.03, 2.97] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.939 |
During the follow-up period (1.1.1998 — 31.12.2019), 585 out of 1085 females with M13_POLNODOSA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_POLNODOSA | 2.422 [1.81, 3.24] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.042 |
During the follow-up period (1.1.1998 — 31.12.2019), 269 out of 625 males with M13_POLNODOSA died.
Mortality risk
Mortality risk for people of age
years, who have M13_POLNODOSA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.36% | 0.392% |
| 5 | 1.66% | 3.074% |
| 10 | 4.388% | 7.997% |
| 15 | 8.081% | 15.044% |
| 20 | 13.718% | 24.31% |
Relationships between endpoints
↥Index endpoint: M13_POLNODOSA – Polyarteritis nodosa
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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