Other specified acquired deformities of limbs

M13_LIMBDEFORM

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M21.8, M21.9
  • Hospital discharge: ICD-9 736[8-9]
  • Cause of death: ICD-10 M21.8, M21.9
  • Cause of death: ICD-9 736[8-9]

2 out of 7 registries used, show all original rules.

194

4. Check minimum number of events

None

194

5. Include endpoints

None

194

6. Filter based on genotype QC (FinnGen only)

178

Control definitions (FinnGen only)

Control exclude
M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1624 978 639
Only index persons 1493 897 596
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 32.12 39.17 21.06
Only index persons 31.42 38.34 21.00

-FinnGen-

Key figures

All Female Male
Number of individuals 178 120 58
Unadjusted period prevalence (%) 0.04 0.04 0.03
Median age at first event (years) 41.38 41.77 40.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
183
Matched controls
1830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M21.8
ICD-10 Finland
Other specified acquired deformities of limbs
+∞
92.8
81
*
M21.9
ICD-10 Finland
Acquired deformity of limb, unspecified
+∞
58.5
53
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
24.1
52.5
40
21
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
20.4
47.5
39
24
7368X
ICD-9 Finland
Other acquired deformities of limbs, Acquired deformities of other parts of limbs
+∞
42.4
39
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
12.1
26.9
29
28
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
22.3
21
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
+∞
22.3
21
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
68.6
21.4
24
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
21.3
20
*
WX320
NOMESCO Finland
Spinalanesthesy
4.7
19.9
59
167
M25.5
ICD-10 Finland
Pain in joint
4.3
19.9
72
238
M19.0
ICD-10 Finland
Primary arthrosis of other joints
32.6
17.9
23
8
M20.1
ICD-10 Finland
Hallux valgus (acquired)
23.7
16.5
23
11
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.5
16.0
95
428
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
+∞
15.9
15
*
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
14.8
14
*
9115
FHL
Epiphysiodesis (in hip luxation trokanter 9408)
+∞
14.8
14
*
L15
ICPC
Knee symptom/complaint
3.8
14.7
58
199
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
6.2
14.5
27
50
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
46.6
14.4
17
*
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
58.0
14.1
16
*
WX702
NOMESCO Finland
Supraglottic ventilation device
6.6
13.9
24
41
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
13.7
13
*
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
150.7
13.6
14
*
X59
ICD-10 Finland
Exposure to unspecified factor
3.6
13.0
53
184
B01AB05
ATC
enoxaparin; parenteral
3.3
12.4
64
257
7369X
ICD-9 Finland
Other acquired deformities of limbs, Acquired deformity of limb, site unspecified
+∞
11.6
11
*
N02AX02
ATC
tramadol; systemic, rectal
3.0
11.5
80
379
M79.6
ICD-10 Finland
Pain in limb
2.9
11.2
94
491
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
16.9
11.1
17
11
J01FF01
ATC
clindamycin; systemic
3.1
10.9
61
255
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.0
10.9
25
56
M16.1
ICD-10 Finland
Other primary coxarthrosis
17.4
10.6
16
10
9271
FHL
Hallux surgery
+∞
10.5
10
*
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
27.8
10.0
13
5
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
8.8
9.6
20
25
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.1
9.6
29
81
ZXA05
NOMESCO Finland
Left side
3.1
9.6
48
187
M20.2
ICD-10 Finland
Hallux rigidus
105.2
9.5
10
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
12.4
9.3
16
14
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
38.8
9.1
11
*
N02AJ06
ATC
codeine and paracetamol; systemic
2.6
9.0
87
475
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
17.4
8.7
13
8
N03AX16
ATC
[U] pregabalin
3.0
8.6
46
185
9102
FHL
Trepanation or removal of the local bone process
21.3
8.6
12
6
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.4
8.6
34
114
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
94.2
8.5
9
*
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
+∞
8.4
8
*
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
+∞
8.4
8
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
+∞
8.4
8
*
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
+∞
8.4
8
*
WX111
NOMESCO Finland
Local infiltration anesthesia
+∞
8.4
8
*
NGK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of knee or lower leg
+∞
8.4
8
*
NE1AA
NOMESCO Finland
Pelvis X-ray examination
8.2
8.4
18
24
N03AX12
ATC
[U] gabapentin; oral
3.5
8.3
32
105
M01AH05
ATC
etoricoxib; oral
2.5
8.3
116
745
NH3EA
NOMESCO Finland
Feet X-ray examination with load
35.1
8.2
10
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
6.7
8.1
20
33
WX704
NOMESCO Finland
Intubation
4.0
8.0
24
66
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
4.9
7.8
18
40
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
15.9
7.8
12
8
M01AH01
ATC
celecoxib; oral
3.4
7.7
31
105
NF1AA
NOMESCO Finland
Hip X-ray examination
7.0
7.6
18
28
ZXD20
NOMESCO Finland
Day surgery
3.3
7.6
32
111
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
83.3
7.5
8
*
NHL99
NOMESCO Finland
Other operation on muscle or tendon of ankle or foot
+∞
7.3
7
*
M01AB05
ATC
diclofenac; systemic, rectal
2.4
7.2
121
821
WX212
NOMESCO Finland
Femoral plexus blockade
21.0
7.2
10
5
S18
ICPC
Laceration/cut
2.3
7.1
88
524
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.9
7.0
36
141
L17
ICPC
Foot/toe symptom/complaint
2.4
6.9
62
321
NH1FA
NOMESCO Finland
Weight-bearing X-ray of ankle
23.5
6.7
9
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.8
6.7
21
60
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
6.7
45
203
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.5
6.5
47
219
M24.8
ICD-10 Finland
Other specific joint derangements, not elsewhere classified
72.3
6.5
7
*
W00
ICD-10 Finland
Fall on same level involving ice and snow
3.1
6.3
29
106
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
+∞
6.3
6
*
M21.5
ICD-10 Finland
Acquired clawhand, clubhand, clawfoot and clubfoot
+∞
6.3
6
*
WX213
NOMESCO Finland
Lower leg blockade
+∞
6.3
6
*
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
+∞
6.3
6
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
6.3
6
*
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
27.7
6.3
8
*
NF1DA
NOMESCO Finland
X-ray of hips
27.7
6.3
8
*
H02AB06
ATC
prednisolone; systemic
2.2
6.2
83
504
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
4.3
6.0
16
40
L13
ICPC
Hip symptom/complaint
2.7
6.0
36
152

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
18
49
3.97
6.09
1.3
1.1
—
—
—
0
0
42
191
2.56
6.07
1.5
1.2
20.99
1.57
u/ml
0.46
14
80
45
217
2.42
5.72
1.5
1.2
11.21
16.94
iu/ml
1.16
17
58
138
1103
2.02
4.08
6.8
8.2
76.18
78.14
u/l
0.23
130
1042
98
708
1.83
3.90
7.8
7.4
1.23
1.22
mmol/l
0.49
85
605
68
445
1.84
3.69
3.9
4.3
7.39
7.39
ph
0.35
57
305
69
462
1.79
3.43
5.4
5.8
—
—
—
0
0
91
664
1.74
3.33
2.7
2.7
—
—
estimate
—
0
0
31
160
2.13
3.29
1.9
2.0
—
—
—
0
0
50
310
1.84
3.16
3.3
3.1
317.95
326.28
umol/l
0.24
43
282
12
37
3.40
2.99
2.1
4.2
2.20
3.40
index
—
5
20
100
769
1.66
2.88
4.5
8.0
9.56
11.73
umol/l
2.43
93
728
82
600
1.66
2.85
8.7
9.0
1.16
1.18
inr
0.14
71
497
84
628
1.62
2.63
6.8
7.4
1.22
1.22
mmol/l
0.12
79
578
36
215
1.84
2.53
2.0
1.6
1269.70
1120.59
nmol/l
0.34
25
161
73
531
1.62
2.53
2.8
3.5
18.45
33.55
ng/l
1.17
39
344
53
355
1.69
2.53
3.3
4.1
—
—
—
0
0
18
84
2.27
2.44
4.1
10.7
24.48
24.95
mmol/l
0.17
18
84
5
8
6.39
2.38
1.0
1.0
21.58
42.06
mg/l
—
5
8
70
511
1.60
2.37
2.3
3.6
2.35
2.37
mmol/l
0.38
62
474
122
1015
1.61
2.34
5.5
4.0
—
1.71
—
0
5
26
149
1.87
2.08
2.3
1.7
—
—
—
0
0
104
850
1.52
2.04
5.0
5.2
6.50
6.49
mmol/l
0.01
97
786
43
289
1.64
2.00
2.0
2.7
2.44
2.44
mmol/l
0.09
37
269
98
797
1.49
1.93
4.6
3.4
0.00
0.01
estimate
0.50
18
161
99
807
1.49
1.92
4.5
3.5
0.00
0.00
estimate
-0.00
19
147
41
276
1.63
1.89
3.1
4.0
20.04
420.83
ng/l
1.89
27
194
27
162
1.78
1.88
1.7
1.5
—
—
—
0
0
50
354
1.57
1.87
2.1
1.9
2.55
2.99
mg/l
0.61
39
302
6
18
3.41
1.76
2.7
2.1
—
—
—
0
0
40
274
1.59
1.72
2.0
1.7
452.44
429.52
pmol/l
0.20
32
239
85
685
1.45
1.68
6.8
6.0
0.68
0.69
%
0.06
80
646
139
1232
1.53
1.68
5.0
4.2
14.84
14.63
pmol/l
0.49
130
1146
165
1525
1.83
1.66
17.0
13.0
23.84
23.33
mg/l
0.05
142
1195
61
463
1.48
1.64
4.6
2.8
0.00
0.02
estimate
0.74
17
127
59
445
1.48
1.63
2.4
2.4
61.07
76.36
u/l
0.49
54
420
47
340
1.51
1.59
1.9
2.1
1.61
1.23
mg/l
0.25
37
262
96
798
1.43
1.58
4.6
3.5
0.00
8.91
estimate
0.50
20
158
90
749
1.40
1.43
6.7
6.2
0.04
0.04
e9/l
0.18
79
640
55
420
1.44
1.41
3.1
2.9
—
—
—
0
0
61
475
1.43
1.41
3.5
3.2
9.54
51.81
e6/l
2.26
46
353
56
430
1.44
1.39
1.4
1.4
0.76
1.36
u/ml
—
9
112
6
23
2.66
1.38
1.2
1.2
—
—
—
0
0
53
404
1.44
1.37
3.1
3.1
0.20
0.33
e6/l
0.38
39
285
89
744
1.38
1.35
6.8
6.2
0.55
0.55
e9/l
0.05
78
637
91
769
1.36
1.27
6.8
6.2
1.78
1.85
e9/l
0.44
83
680
16
93
1.79
1.26
1.5
1.2
110.02
409.14
u/ml
0.93
16
85
50
384
1.42
1.23
2.3
1.5
19.51
20.81
nmol/l
0.23
40
319
5
19
2.68
1.22
4.0
2.6
8.90
9.19
kpa
—
5
19
5
19
2.68
1.22
4.0
2.6
4.74
5.14
kpa
—
5
19
77
638
1.36
1.20
4.4
3.2
6.27
6.24
ph
0.08
45
380
27
184
1.55
1.19
1.2
1.2
—
—
—
0
0
5
20
2.54
1.16
1.0
1.1
—
—
—
0
0
74
614
1.34
1.13
4.9
3.2
0.00
0.03
estimate
0.68
17
133
16
97
1.71
1.11
2.4
2.3
24.76
7.49
au/ml
—
5
7
7
32
2.23
1.09
1.1
1.7
—
—
—
0
0
5
108
0.45
1.04
1.2
1.1
—
—
—
0
0
19
123
1.61
1.04
4.1
3.4
—
—
—
0
0
22
149
1.54
1.01
1.2
1.2
—
—
—
0
0
14
84
1.72
1.01
2.1
2.6
72.07
184.20
ng/l
1.67
14
77
11
61
1.85
1.01
2.8
5.5
36.98
36.99
°c
0.02
11
61
71
595
1.32
1.00
2.5
1.9
89.06
92.87
pmol/l
0.29
31
324
47
371
1.36
0.98
1.4
1.4
2.11
2.17
g/l
0.13
23
236
18
118
1.58
0.95
10.1
12.6
—
—
—
0
0
13
78
1.72
0.94
1.5
1.6
—
—
—
0
0
15
94
1.65
0.94
1.4
1.7
—
—
—
0
0
6
30
2.03
0.87
5.8
5.6
0.69
1.26
mmol/l
—
6
25
89
780
1.27
0.86
6.8
6.5
0.18
0.18
e9/l
0.04
80
679
20
138
1.50
0.86
10.3
9.3
7.39
7.43
ph
—
9
76
10
57
1.80
0.85
16.5
13.2
16.43
16.30
%
—
10
52
14
209
0.64
0.81
1.2
1.4
—
—
—
0
0
8
48
1.70
0.80
1.0
1.1
—
—
—
0
0
13
196
0.64
0.79
1.3
1.8
—
—
—
0
0
13
83
1.61
0.77
1.4
3.1
—
—
—
0
0
10
159
0.61
0.76
1.6
1.7
3.62
3.37
mmol/l
—
5
120
18
125
1.49
0.76
1.3
1.3
219.06
118.69
u/ml
—
8
55
15
100
1.54
0.75
1.4
1.7
—
—
—
0
0
15
101
1.53
0.73
1.4
1.7
—
—
—
0
0
64
551
1.25
0.70
4.3
3.8
63.56
66.66
e6/l
0.02
46
377
79
697
1.23
0.69
11.6
10.0
0.00
0.01
e9/l
0.53
65
554
56
481
1.24
0.62
3.1
3.3
7.58
7.73
mmol/l
0.09
46
417
11
72
1.56
0.60
1.4
2.0
—
—
—
0
0
11
72
1.56
0.60
1.0
1.6
—
—
—
0
0
8
52
1.56
0.60
1.6
1.3
—
—
—
0
0
6
35
1.74
0.58
3.5
2.4
7.41
7.41
ph
—
6
35
167
1614
1.40
0.58
14.3
11.2
—
—
—
0
0
6
36
1.69
0.57
1.0
1.3
—
—
—
0
0
52
447
1.23
0.57
5.9
6.7
—
—
—
0
0
14
99
1.45
0.56
1.4
1.7
—
—
—
0
0
6
38
1.60
0.55
1.3
1.2
—
—
—
0
0
14
100
1.43
0.53
1.4
1.7
—
—
—
0
0
6
39
1.56
0.53
8.0
3.5
0.75
0.92
%
—
6
34
152
1455
1.26
0.53
6.2
5.1
1.74
1.86
mu/l
0.52
146
1363
13
92
1.44
0.52
2.8
3.3
—
—
—
0
0
20
253
0.76
0.48
1.4
1.9
—
—
—
0
0
7
49
1.45
0.46
1.0
1.2
—
—
—
0
0
48
418
1.20
0.46
3.4
3.3
102.01
71.47
mg/l
0.18
30
263
7
50
1.42
0.45
8.3
3.1
1.91
1.35
%
—
7
44
11
78
1.44
0.44
12.7
12.5
0.67
0.67
%
0.01
11
78
35
408
0.82
0.43
2.4
2.2
—
—
—
0
0
0
15
0.00
0.41
0.0
2.7
—
20.78
—
0
9
0
16
0.00
0.41
0.0
2.3
—
—
—
0
0
11
80
1.40
0.39
12.7
12.3
1.34
1.59
%
0.37
11
80
147
1518
0.84
0.37
5.4
4.6
4.72
4.70
mmol/l
0.07
140
1427
48
428
1.16
0.36
4.2
3.9
15.79
11.05
mg/mmol
0.18
27
265
6
44
1.38
0.35
1.0
1.9
—
—
—
0
0
147
1515
0.85
0.33
5.2
4.5
1.46
1.47
mmol/l
0.09
140
1416
91
853
1.13
0.33
8.5
10.8
3.80
4.15
e9/l
1.14
84
737
27
231
1.20
0.32
2.2
1.7
—
—
—
0
0
21
248
0.83
0.30
2.0
1.5
—
—
—
0
0
13
162
0.79
0.29
1.2
1.2
—
—
—
0
0
8
62
1.30
0.28
1.8
1.9
—
—
—
0
0
13
104
1.27
0.27
2.0
3.5
55.00
75.26
e9/l
—
7
73
22
188
1.19
0.27
7.8
7.3
103.00
104.47
mmol/l
0.78
22
188
8
67
1.20
0.26
5.9
3.9
—
—
—
0
0
11
138
0.78
0.26
1.2
1.6
—
—
—
0
0
10
126
0.78
0.25
6.9
9.4
9.57
7.08
mmol/l
—
10
119
25
218
1.17
0.25
1.7
2.0
50.60
88.22
ug/g
0.95
20
169
13
106
1.24
0.24
1.8
1.7
—
—
—
0
0
5
38
1.32
0.23
2.2
2.3
—
—
—
0
0
150
1534
0.88
0.23
5.9
5.1
2.82
2.80
mmol/l
0.13
143
1440
13
107
1.23
0.22
1.2
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
5.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.17
0.21
1.4
3.0
12.76
12.12
mg/l
—
5
43
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
2.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
0.59
—
0
14
17
146
1.18
0.20
1.6
3.5
1.63
1.81
%
0.67
17
139
37
340
1.11
0.18
4.9
6.0
—
—
—
0
0
7
60
1.17
0.18
2.7
4.9
24.14
24.65
mmol/l
—
7
60
19
167
1.15
0.17
1.5
1.4
—
—
—
0
0
38
352
1.10
0.16
5.4
3.3
1.02
1.02
kg/l
0.24
30
228
46
431
1.09
0.16
4.1
3.5
0.00
0.01
estimate
0.50
19
149
6
78
0.76
0.16
1.3
1.3
0.78
0.91
g/l
—
6
78
145
1422
1.09
0.15
5.8
5.5
37.50
38.19
mmol/mol
0.50
139
1333
10
84
1.20
0.14
1.2
1.2
—
—
—
0
0
8
100
0.79
0.14
1.5
1.4
1.46
1.19
g/l
—
8
95
26
239
1.10
0.13
3.9
2.8
0.73
2.50
e6/l
—
10
103
32
343
0.92
0.12
1.9
1.7
—
—
—
0
0
20
217
0.91
0.10
2.6
3.3
29.23
29.82
s
0.25
20
212
5
45
1.11
0.10
7.8
1.4
0.20
0.23
g/l
—
5
45
49
470
1.06
0.09
3.0
2.4
—
—
—
0
0
149
1472
1.07
0.08
4.8
4.4
5.67
5.82
mmol/l
0.88
138
1367
16
146
1.11
0.08
4.8
5.7
7.36
7.38
ph
—
9
87
6
58
1.04
0.08
1.0
1.2
—
—
—
0
0
14
154
0.90
0.08
1.4
1.6
—
—
—
0
0
6
74
0.80
0.07
1.3
1.1
1.40
1.53
g/l
—
6
74
8
74
1.08
0.07
3.6
4.6
—
—
—
0
0
8
75
1.07
0.07
3.1
4.4
0.59
0.61
%
—
8
75
21
196
1.08
0.07
1.1
1.3
—
—
—
0
0
61
626
0.96
0.06
2.2
1.9
1.29
1.39
mmol/l
0.46
52
534
50
487
1.04
0.04
1.4
1.5
—
—
—
0
0
65
661
0.97
0.03
2.7
3.0
—
—
—
0
0
144
1430
1.03
0.03
4.4
3.9
1.26
1.24
mmol/l
0.14
135
1336
62
629
0.98
0.02
1.9
2.0
—
—
—
0
0
13
124
1.05
0.00
4.5
5.2
4.72
4.69
kpa
0.02
13
119
20
206
0.97
0.00
2.5
2.7
0.44
0.82
ug/l
—
10
118
12
117
1.03
0.00
2.3
2.4
11.18
10.03
g/l
0.95
12
109
0
9
0.00
-0.00
0.0
1.0
—
1115.56
—
0
9
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
56.49
—
0
7
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
24.00
—
0
8
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
0.00
—
0
6
0
8
0.00
-0.00
0.0
1.6
—
2031.25
—
0
8
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
7
77
0.91
-0.00
2.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
20.50
—
0
6
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
11.83
—
0
6
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_LIMBDEFORM and mortality.

Females

Parameter HR [95% CI] p-value
M13_LIMBDEFORM 1.57 [1.14, 2.17] 0.006
Birth year 0.994 [0.99, 1.0] 0.203

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 621 females with M13_LIMBDEFORM died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_LIMBDEFORM.

N-year risk Females Males
1 0.187% No data
5 0.894% No data
10 2.358% No data
15 4.271% No data
20 7.636% No data

Relationships between endpoints

Index endpoint: M13_LIMBDEFORM – Other specified acquired deformities of limbs

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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