No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
335 |
4. Check minimum number of eventsNone |
335 |
5. Include endpointsNone |
335 |
6. Filter based on genotype QC (FinnGen only) |
295 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M20
- Name in latin
- Alia deformitas hallucis [acquisita]
Similar endpoints
↥List of similar endpoints to
Other deformity of hallux (acquired)
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1768 | 1316 | 446 |
| Only index persons | 1661 | 1261 | 400 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.01 |
| Only index persons | 0.04 | 0.05 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 56.00 | 56.11 | 55.53 |
| Only index persons | 55.69 | 55.82 | 55.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 295 | 225 | 70 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.03 |
| Median age at first event (years) | 55.29 | 54.05 | 59.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 305
- Matched controls
- 3050
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M20.3
ICD-10 Finland
Other deformity of hallux (acquired)
+∞
307.7
273
*
M20.1
ICD-10 Finland
Hallux valgus (acquired)
77.8
223.4
125
27
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
29.0
121.9
88
42
M19.0
ICD-10 Finland
Primary arthrosis of other joints
39.0
112.5
72
24
M17.1
ICD-10 Finland
Other primary gonarthrosis
20.9
106.0
89
59
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
104.3
94
*
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
172.9
86.2
87
7
WX320
NOMESCO Finland
Spinalanesthesy
7.8
67.2
131
270
M16.1
ICD-10 Finland
Other primary coxarthrosis
22.8
65.5
50
26
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
15.3
64.3
61
49
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
20.2
63.2
51
30
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
62.7
58
*
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
53.8
50
*
M20.2
ICD-10 Finland
Hallux rigidus
179.8
45.2
46
*
9271
FHL
Hallux surgery
+∞
43.8
41
*
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
91.9
43.3
47
6
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
9.8
42.0
53
64
NHG70
NOMESCO Finland
Arthroplasty of first tarsometatarsal joint
+∞
40.5
38
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
40.5
38
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
441.4
40.1
39
*
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
+∞
39.4
37
*
M25.5
ICD-10 Finland
Pain in joint
4.7
37.0
126
400
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
35.1
33
*
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
135.5
34.5
36
*
7351A
ICD-9 Finland
Acquired deformities of toe, Hallux varus (acquired)
+∞
34.0
32
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
83.7
33.7
37
5
M20.5
ICD-10 Finland
Other deformities of toe(s) (acquired)
+∞
31.8
30
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
12.2
30.7
32
29
NHG82
NOMESCO Finland
Fusion of other tarsal joint
+∞
28.6
27
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.6
26.7
163
743
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
283.3
26.1
26
*
73799
ICD-8 Finland
Hallux valgus and varus
+∞
24.3
23
*
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
+∞
24.3
23
*
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
259.5
24.0
24
*
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
5.5
23.6
51
108
L17
ICPC
Foot/toe symptom/complaint
3.4
23.4
132
562
P01BA02
ATC
hydroxychloroquine; oral
9.8
23.3
28
31
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
38.3
22.5
28
8
L15
ICPC
Knee symptom/complaint
3.6
21.7
96
349
N02AX02
ATC
tramadol; systemic, rectal
3.1
21.0
152
740
S18
ICPC
Laceration/cut
3.1
20.5
178
956
M01AX05
ATC
glucosamine; oral
3.9
20.4
72
224
ZXA00
NOMESCO Finland
Right side
3.3
20.1
108
440
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.5
19.9
55
143
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
6.4
19.3
34
59
N02AJ06
ATC
codeine and paracetamol; systemic
3.0
19.3
151
759
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
20.4
19.0
28
15
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
21.0
18.6
27
14
M77.4
ICD-10 Finland
Metatarsalgia
5.6
18.4
37
73
L04AX03
ATC
methotrexate; systemic
6.8
18.4
30
48
B01AB05
ATC
enoxaparin; parenteral
3.0
18.3
115
509
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
19.6
18.1
27
15
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
+∞
17.9
17
*
L84
ICD-10 Finland
Corns and callosities
8.3
17.7
24
31
M01AH05
ATC
etoricoxib; oral
2.9
17.5
201
1216
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
45.0
17.5
21
5
N03AX12
ATC
[U] gabapentin; oral
3.7
17.4
65
209
NH3EA
NOMESCO Finland
Feet X-ray examination with load
95.4
16.7
18
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
13.9
16.5
28
22
M79.6
ICD-10 Finland
Pain in limb
2.7
15.8
159
884
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
4.7
15.8
39
92
1221
FHL
Arthroscopy and meniscus surgery
168.3
15.6
16
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
168.3
15.6
16
*
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
30.4
15.4
20
7
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
5.1
15.3
34
73
M13.9
ICD-10 Finland
Arthritis, unspecified
15.0
15.3
25
18
M09AX01
ATC
hyaluronic acid; parenteral
16.2
15.2
24
16
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
5.9
15.1
28
51
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
26.6
14.9
20
8
M19.9
ICD-10 Finland
Arthrosis, unspecified
11.7
14.8
27
25
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
84.3
14.7
16
*
NF1AA
NOMESCO Finland
Hip X-ray examination
4.8
14.5
35
81
L16
ICPC
Ankle symptom/complaint
3.6
14.4
54
173
NFB40
NOMESCO Finland
Primary total prosthetic replacement of hip joint using hybrid technique
31.7
14.0
18
6
ZXA05
NOMESCO Finland
Left side
2.8
13.9
89
390
N03AX16
ATC
[U] pregabalin
2.9
13.8
84
358
WX002
NOMESCO Finland
Sedation and analgesia
3.0
13.6
72
284
M01AH01
ATC
celecoxib; oral
3.1
13.6
66
248
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
146.2
13.6
14
*
SPAT1153
SPAT
Removal of sutures
2.6
12.9
109
546
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
12.6
12
*
WX111
NOMESCO Finland
Local infiltration anesthesia
135.3
12.5
13
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.5
12.2
101
500
Z01.2
ICD-10 Finland
Dental examination
2.4
12.1
155
931
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
5.5
11.9
24
47
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.0
11.9
60
229
M48.0
ICD-10 Finland
Spinal stenosis
3.3
11.6
48
163
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.7
11.2
38
113
L13
ICPC
Hip symptom/complaint
2.7
11.1
72
314
B01AF01
ATC
rivaroxaban; oral
3.4
11.1
42
135
M67.0
ICD-10 Finland
Short Achilles tendon (acquired)
45.1
11.0
13
*
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
3.6
11.0
38
115
J01DB01
ATC
cefalexin; oral
3.0
10.9
261
2026
R4110, ,
SPAT
2.9
10.7
58
230
M02AA07
ATC
piroxicam; topical
2.3
10.6
122
690
WX214
NOMESCO Finland
Plexus blockade at the ankle
+∞
10.5
10
*
M19.2
ICD-10 Finland
Other secondary arthrosis
+∞
10.5
10
*
M22.4
ICD-10 Finland
Chondromalacia patellae
+∞
10.5
10
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
10.5
10
*
A02BC05
ATC
esomeprazole; systemic
2.2
10.4
140
843
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
33.8
10.4
13
*
J01FF01
ATC
clindamycin; systemic
2.4
10.3
93
473
M01AH02
ATC
rofecoxib; oral
3.2
10.3
44
152
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.1
10.2
29
76
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
4.5
10.0
25
59
L01BA01
ATC
methotrexate; systemic
41.5
10.0
12
*
M01AX17
ATC
nimesulide; oral
2.4
9.9
80
387
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
9.6
125
737
WX702
NOMESCO Finland
Supraglottic ventilation device
4.1
9.6
27
70
M54.4
ICD-10 Finland
Lumbago with sciatica
2.6
9.6
66
295
L89
ICPC
Osteoarthrosis of hip
15.7
9.6
15
10
M01AC06
ATC
meloxicam; systemic, rectal
2.2
9.5
115
659
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.6
9.5
32
95
UJF32
NOMESCO Finland
Coloscopy
2.3
9.4
96
512
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
9.4
9
*
7170A
ICD-9 Finland
Internal derangement of knee, Old bucket handle tear of medial meniscus
+∞
9.4
9
*
SPAT1229
SPAT
Assessment of need for aid
3.7
9.3
31
91
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.4
9.3
82
411
AA1AD
NOMESCO Finland
CT of head and brain
2.2
9.2
108
611
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
37.9
9.1
11
*
J02AC01
ATC
fluconazole; systemic
2.1
9.0
142
898
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
13.1
9.0
15
12
M03BX02
ATC
tizanidine; oral
2.1
8.8
194
1383
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
51.5
8.7
10
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
8.6
159
1058
WZA00
NOMESCO Finland
Concise certificate
4.5
8.5
21
49
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
8.4
8
*
H02AB07
ATC
prednisone; oral
2.7
8.3
49
202
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
4.1
8.3
23
59
L28
ICPC
Limited function/disability (L)
2.4
8.2
67
324
NHQ40
NOMESCO Finland
Amputation of toe
17.8
8.1
12
7
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.1
8.1
23
60
A02BC02
ATC
pantoprazole; systemic
2.1
8.1
215
1620
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.4
8.1
30
95
A46
ICD-10 Finland
Erysipelas
2.7
8.0
46
187
M19.8
ICD-10 Finland
Other specified arthrosis
6.9
8.0
19
29
SPAT1211
SPAT
Application of soft bandage
3.2
7.9
32
107
ZXA10
NOMESCO Finland
Bilateral
2.3
7.9
67
329
N02BE01
ATC
paracetamol; systemic, rectal
3.0
7.8
277
2335
NHM99
NOMESCO Finland
Other operation on fascia, ganglion, synovial sheath or bursa of ankle or foot
46.2
7.8
9
*
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
46.2
7.8
9
*
H02AB06
ATC
prednisolone; systemic
2.0
7.7
144
951
E0000UV, ,
ATC
2.0
7.6
138
901
NG2AA
NOMESCO Finland
Patella X-ray examination
25.7
7.6
10
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.5
7.6
27
83
L08
ICPC
Shoulder symptom/complaint
2.2
7.6
75
392
M54.5
ICD-10 Finland
Low back pain
2.0
7.5
109
658
N06AX21
ATC
duloxetine; oral
2.7
7.5
42
169
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
82.0
7.4
8
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
7.4
47
201
M70.6
ICD-10 Finland
Trochanteric bursitis
2.5
7.3
51
228
72410
ICD-8 Finland
Internal derangement of joint, Other shoulder derangement
+∞
7.3
7
*
M17.5
ICD-10 Finland
Other secondary gonarthrosis
+∞
7.3
7
*
M96.0
ICD-10 Finland
Pseudarthrosis after fusion or arthrodesis
+∞
7.3
7
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.2
7.3
75
397
L03
ICPC
Low back symptom/complaint
2.1
7.3
93
535
J01DA01
ATC
[U] cefalexin
1.9
7.2
190
1399
M01AE01
ATC
ibuprofen; systemic, rectal
3.0
7.2
278
2370
NHL99
NOMESCO Finland
Other operation on muscle or tendon of ankle or foot
30.8
7.2
9
*
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
12.4
7.1
12
10
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
12.4
7.1
12
10
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.7
7.1
42
173
S20
ICPC
Corn/callosity
10.4
7.1
13
13
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.7
7.0
40
162
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
3.6
7.0
23
67
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
6.9
74
397
J45.9
ICD-10 Finland
Asthma, unspecified
2.2
6.9
68
353
M67.4
ICD-10 Finland
Ganglion
3.3
6.9
27
88
NBL00
NOMESCO Finland
Suture or reinsertation of rotator cuff of shoulder
4.3
6.9
18
44
M15
ICD-10 Finland
Polyarthrosis
4.1
6.8
19
49
M02AA10
ATC
ketoprofen; topical
2.4
6.8
51
236
D11
ICPC
Diarrhoea
2.5
6.8
44
190
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.5
6.8
45
197
R29
ICPC
Respiratory symptom/complaint other
3.4
6.7
25
79
J01MA02
ATC
ciprofloxacin; systemic
1.9
6.7
119
764
UJD02
NOMESCO Finland
Gastroscopy
3.7
6.7
21
59
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
8.1
6.7
14
18
J01DA09
ATC
[U] cefadroxil
2.0
6.7
83
472
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
6.6
44
192
A02BC03
ATC
lansoprazole; oral
2.0
6.6
96
576
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
71.3
6.4
7
*
L04AA13
ATC
[U] leflunomide
71.3
6.4
7
*
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
71.3
6.4
7
*
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.3
6.4
24
76
SFA10
NOMESCO Finland
One-surface restoration
1.8
6.4
166
1197
M03BC01
ATC
orphenadrine (citrate); systemic
2.1
6.4
68
364
J01AA02
ATC
doxycycline; systemic
2.1
6.4
243
1988
TQW40
NOMESCO Finland
Remowal of suture of skin
3.1
6.3
27
93
M01AB05
ATC
diclofenac; systemic, rectal
1.9
6.3
191
1444
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
18.5
6.3
9
5
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.8
6.3
32
122
ZXE00
NOMESCO Finland
One hour or less
1.9
6.3
116
752
M21.0
ICD-10 Finland
Valgus deformity, not elsewhere classified
+∞
6.3
6
*
B01AX06
ATC
[U] rivaroxaban
+∞
6.3
6
*
9351
FHL
Metatarsus osteotomies
+∞
6.3
6
*
NHL20
NOMESCO Finland
Myotomy or tenotomy of foot
+∞
6.3
6
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.0
6.3
92
553
M35.7
ICD-10 Finland
Hypermobility syndrome
27.3
6.3
8
*
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
8.9
6.1
12
14
M15.8
ICD-10 Finland
Other polyarthrosis
8.9
6.1
12
14
M10.0
ICD-10 Finland
Idiopathic gout
10.3
6.1
11
11
R06AE07
ATC
cetirizine; oral
1.8
6.1
136
934
N05BA01
ATC
diazepam; systemic, rectal
2.3
6.1
49
234
N05BA04
ATC
oxazepam; oral
2.0
6.1
86
510
EB1VA, ,
NOMESCO Finland
2.2
6.1
56
283
L12
ICPC
Hand/finger symptom/complaint
2.2
6.1
56
283
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
6.0
109
701
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
19
14
14.38
11.62
1.7
1.0
—
—
—
0
0
81
381
2.53
10.71
1.5
1.2
30.73
16.78
iu/ml
0.51
29
100
248
1883
2.70
10.71
6.6
3.5
11.54
12.45
mm/h
0.58
237
1726
166
1069
2.21
10.47
3.1
2.6
—
—
estimate
—
0
0
208
1522
2.15
8.80
4.1
5.0
6.48
6.73
mmol/l
1.48
197
1435
100
562
2.16
8.53
2.2
2.5
340.44
337.31
umol/l
0.12
88
492
173
1193
2.04
8.46
3.8
5.2
35.76
35.68
g/l
0.06
154
1124
69
339
2.34
8.10
1.5
1.2
2.48
2.89
u/ml
0.08
27
126
173
1224
1.96
7.53
5.3
6.3
1.23
1.22
mmol/l
0.54
162
1125
174
1245
1.93
7.20
2.7
2.4
83.02
79.08
nmol/l
0.96
155
1108
197
1481
1.93
6.89
8.5
9.4
3.94
4.10
e9/l
0.47
176
1278
289
2531
3.70
6.87
19.4
14.8
20.74
25.58
mg/l
2.10
253
1989
108
672
1.94
6.71
2.6
2.1
2.63
2.94
mg/l
0.96
98
558
124
812
1.89
6.57
2.8
3.3
1023.41
1186.13
ng/l
0.31
104
692
298
2751
4.63
5.98
14.4
11.2
24.82
24.27
u/l
0.22
290
2657
244
2029
2.01
5.66
8.8
8.2
73.71
79.64
u/l
2.38
231
1913
252
2127
2.06
5.50
5.5
4.4
14.87
14.96
pmol/l
0.25
229
1941
181
1393
1.74
5.17
6.5
7.0
1.23
1.22
mmol/l
0.73
156
1208
118
810
1.75
5.06
1.8
1.6
22.05
20.95
nmol/l
0.31
106
673
160
1205
1.69
4.82
2.4
2.1
97.67
98.96
pmol/l
0.13
79
626
277
2470
2.32
4.52
6.9
5.5
1.87
1.97
mu/l
0.61
259
2258
46
241
2.07
4.51
4.1
3.1
—
—
—
0
0
177
1386
1.66
4.46
5.1
3.9
0.00
0.00
estimate
-0.00
37
297
299
2812
4.22
4.41
30.3
22.5
254.98
253.31
e9/l
0.18
292
2738
299
2812
4.22
4.41
30.2
22.5
4.38
4.44
e12/l
1.72
292
2730
159
1215
1.64
4.39
3.6
2.8
101.41
107.46
ug/l
0.23
147
1128
176
1392
1.63
4.14
5.0
4.0
0.00
0.05
estimate
1.46
37
288
285
2591
2.52
4.12
5.8
5.0
4.68
4.72
mmol/l
0.23
267
2398
73
461
1.77
4.08
1.7
1.9
—
—
—
0
0
275
2467
2.17
4.05
7.0
6.5
38.40
39.45
mmol/mol
2.01
258
2272
140
1053
1.61
4.01
3.6
3.7
20.56
72.96
ng/l
1.00
91
775
173
1374
1.60
3.91
5.1
3.9
0.00
0.00
estimate
-0.00
37
293
283
2579
2.35
3.81
5.5
4.9
1.57
1.53
mmol/l
0.62
266
2366
287
2638
2.49
3.67
6.6
5.8
2.69
2.74
mmol/l
0.36
270
2438
177
1434
1.56
3.52
5.5
7.2
9.76
11.60
umol/l
2.25
167
1364
143
1108
1.55
3.45
2.2
1.9
1.25
1.29
mmol/l
0.24
120
908
10
23
4.46
3.34
1.1
1.2
—
—
—
0
0
19
79
2.50
3.20
1.5
1.9
—
—
—
0
0
82
569
1.60
3.15
2.6
2.1
—
—
—
0
0
63
409
1.68
3.15
2.4
2.4
2.43
2.32
g/l
0.68
57
384
113
848
1.53
3.08
2.7
2.6
72.16
70.43
u/l
0.06
102
778
15
57
2.72
3.01
1.2
1.8
—
—
—
0
0
119
909
1.51
2.96
3.5
4.1
3.40
7.81
mg/mmol
1.65
65
568
47
289
1.74
2.85
2.4
5.2
242.64
239.91
u/l
0.07
42
274
5
6
8.44
2.76
1.4
1.2
1.06
1.09
ratio
—
5
6
19
87
2.26
2.63
1.7
2.0
—
—
—
0
0
104
789
1.48
2.62
5.2
3.8
0.00
0.00
estimate
0.50
37
271
30
168
1.87
2.47
1.5
1.6
—
—
—
0
0
51
334
1.63
2.46
1.6
1.9
—
—
—
0
0
194
1669
1.45
2.45
3.8
3.3
42.83
44.39
u/l
0.15
183
1550
125
999
1.43
2.35
3.3
3.7
2.36
2.37
mmol/l
0.33
115
899
131
1057
1.42
2.33
5.3
3.9
0.00
0.17
estimate
0.89
29
236
53
356
1.59
2.31
1.6
1.8
—
—
—
0
0
81
599
1.48
2.28
6.0
3.8
1.02
1.02
kg/l
0.66
59
387
5
9
5.63
2.22
1.2
1.2
—
—
—
0
0
76
558
1.48
2.21
1.8
1.7
1.32
1.33
mg/l
0.00
56
433
62
440
1.51
2.12
2.9
2.5
1.34
1.28
e6/l
0.04
29
227
265
2455
1.61
2.08
4.7
4.2
1.30
1.25
mmol/l
0.41
246
2235
65
469
1.49
2.05
1.7
1.6
1251.31
1203.23
nmol/l
0.16
54
341
25
143
1.82
1.96
5.1
8.5
15.81
15.42
%
0.27
25
137
9
33
2.78
1.94
1.4
1.3
—
—
—
0
0
57
407
1.49
1.89
2.9
2.7
3.78
3.22
e6/l
0.17
24
193
270
2525
1.60
1.88
19.0
14.9
78.40
78.08
ml/min/173m2
0.10
256
2342
169
1460
1.35
1.85
2.7
2.8
—
—
—
0
0
273
2565
1.61
1.80
6.0
5.1
5.79
5.97
mmol/l
2.85
251
2352
93
737
1.38
1.75
3.3
2.9
0.56
0.56
e6/l
0.00
71
540
5
13
3.89
1.72
1.6
2.5
—
—
—
0
0
7
26
2.73
1.59
1.1
1.5
—
—
—
0
0
7
26
2.73
1.59
1.1
1.5
—
—
—
0
0
7
26
2.73
1.59
1.1
1.5
—
—
—
0
0
75
583
1.38
1.58
1.9
1.7
464.49
36722433.55
pmol/l
0.75
63
482
47
340
1.45
1.48
4.2
5.4
1.05
1.05
mmol/l
0.01
41
306
103
850
1.32
1.46
3.2
3.2
34.70
30.20
u/l
0.60
94
808
7
29
2.45
1.40
1.1
1.5
—
—
—
0
0
7
29
2.45
1.40
1.1
1.5
—
—
—
0
0
5
17
2.97
1.36
1.0
1.1
—
—
—
0
0
13
68
1.95
1.35
1.2
1.4
—
—
—
0
0
65
508
1.36
1.32
4.0
3.9
111.62
387.08
ng/l
1.61
55
403
31
212
1.51
1.29
1.4
1.4
—
—
—
0
0
22
139
1.63
1.27
1.1
1.4
—
49.91
—
0
14
6
25
2.43
1.25
1.0
1.2
—
—
—
0
0
9
45
2.03
1.24
1.0
1.3
37.09
17.29
u/l
—
9
38
91
754
1.29
1.23
4.6
3.5
0.00
0.02
estimate
0.68
26
225
28
191
1.51
1.19
3.0
3.8
19.73
152.50
u/ml
1.37
28
185
13
72
1.84
1.17
1.7
1.8
—
—
—
0
0
5
20
2.52
1.15
2.6
1.8
—
—
—
0
0
5
21
2.40
1.09
1.6
2.1
59.20
96.29
ng/l
—
5
21
73
601
1.28
1.03
2.4
3.0
2.44
2.47
mmol/l
1.22
63
545
7
35
2.02
1.00
3.6
1.4
12.00
11.32
mmol/l
—
7
35
58
466
1.30
0.99
1.7
1.5
—
—
—
0
0
58
467
1.30
0.97
6.4
5.1
2.28
3.10
ug/l
0.39
53
413
10
55
1.85
0.93
4.6
4.3
0.84
0.82
nmol/l
—
10
47
6
29
2.09
0.90
1.2
1.5
—
—
—
0
0
8
43
1.88
0.88
1.5
1.2
—
—
—
0
0
13
80
1.65
0.86
2.8
1.7
—
—
—
0
0
8
45
1.80
0.85
1.5
2.9
8.31
7.30
pmol/l
—
8
45
34
260
1.35
0.82
6.0
7.8
119.50
120.68
g/l
0.11
34
255
25
182
1.41
0.81
1.2
1.2
110.61
148.70
u/ml
—
8
75
15
98
1.56
0.80
2.6
1.8
—
—
—
0
0
7
122
0.56
0.80
1.3
1.2
—
—
—
0
0
0
24
0.00
0.79
0.0
3.6
—
848.25
—
0
24
9
57
1.60
0.71
1.2
1.4
—
—
—
0
0
38
303
1.29
0.71
1.6
3.1
5.42
7.07
umol/l
0.73
33
267
28
215
1.33
0.68
2.4
3.7
1.24
1.23
mmol/l
0.19
22
177
7
43
1.64
0.67
1.0
1.4
—
—
—
0
0
13
86
1.53
0.67
1.1
2.1
0.00
0.00
g/l
—
8
72
46
379
1.25
0.67
5.4
6.4
104.02
103.96
mmol/l
0.03
46
379
7
44
1.60
0.65
1.0
1.1
—
—
—
0
0
25
192
1.33
0.61
1.5
1.5
—
—
—
0
0
26
201
1.32
0.61
3.2
3.1
164.92
208.73
ng/l
0.37
26
188
8
53
1.52
0.59
1.1
1.5
—
—
—
0
0
24
185
1.32
0.58
2.0
2.8
64.00
59.37
ml/min/173m2
0.27
13
75
6
38
1.59
0.54
1.2
1.5
—
—
—
0
0
70
616
1.18
0.54
1.3
1.3
0.59
1.15
u/ml
1.29
22
156
10
66
1.53
0.53
1.4
1.5
—
—
—
0
0
10
66
1.53
0.53
1.4
1.5
—
—
—
0
0
6
40
1.51
0.52
1.2
1.5
—
—
—
0
0
7
46
1.53
0.48
1.3
1.5
—
—
—
0
0
35
292
1.22
0.48
6.1
7.1
—
—
—
0
0
5
85
0.58
0.46
2.2
2.8
26.74
25.37
mmol/l
—
5
85
7
50
1.41
0.45
1.4
1.2
—
—
—
0
0
39
332
1.20
0.44
6.4
4.8
34.44
33.48
%
0.27
32
213
8
56
1.44
0.43
1.4
1.4
—
—
—
0
0
8
56
1.44
0.43
1.4
1.4
—
—
—
0
0
21
168
1.27
0.41
7.7
8.4
1.37
1.39
%
0.02
21
168
11
79
1.41
0.41
1.4
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
5
36
1.40
0.38
1.4
1.3
—
—
—
0
0
10
72
1.40
0.37
1.1
1.0
—
1.18
—
0
6
15
190
0.78
0.36
2.1
1.9
2.88
3.51
mmol/l
—
9
132
20
162
1.25
0.36
2.8
3.5
24.32
24.41
mmol/l
0.04
20
157
5
76
0.65
0.36
1.4
1.2
—
—
—
0
0
5
77
0.64
0.36
1.4
1.2
—
—
—
0
0
6
42
1.44
0.35
1.2
1.6
—
—
—
0
0
43
389
1.12
0.25
1.4
1.5
—
—
—
0
0
19
161
1.19
0.24
3.1
2.0
—
—
—
0
0
29
256
1.15
0.24
2.0
2.1
3.20
3.36
ratio
0.34
22
199
31
277
1.13
0.22
3.7
2.9
0.71
0.83
ug/l
0.58
24
191
19
163
1.18
0.22
8.7
8.6
0.54
0.67
%
1.37
19
163
5
41
1.22
0.22
1.6
1.7
—
—
—
0
0
5
42
1.19
0.21
4.2
4.0
70.88
93.61
u/ml
—
5
42
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
11
134
0.81
0.21
1.2
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
5.3
—
183.31
—
0
13
21
186
1.14
0.17
1.7
2.9
129.29
127.54
g/l
0.11
21
178
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
9
78
1.16
0.15
4.2
2.9
0.58
0.39
iu/ml
—
9
44
9
82
1.10
0.15
1.8
2.8
—
—
—
0
0
11
93
1.19
0.14
1.2
1.2
—
—
—
0
0
32
302
1.07
0.09
3.2
3.3
5.88
5.77
kpa
0.32
32
288
40
382
1.05
0.08
5.6
4.4
21.85
22.18
%
0.05
23
200
8
75
1.07
0.07
1.9
1.3
62.50
486.76
pmol/l
—
8
75
7
83
0.84
0.07
1.3
1.2
1.51
1.60
g/l
—
7
83
7
85
0.82
0.07
1.9
1.4
—
—
—
0
0
12
112
1.07
0.03
1.7
1.6
—
—
—
0
0
14
148
0.94
0.02
1.6
3.1
25.91
25.02
mmol/l
0.60
14
143
17
177
0.96
0.01
3.5
2.0
—
—
—
0
0
26
253
1.03
0.01
2.0
2.8
4.65
4.50
kpa
0.14
26
240
14
139
1.01
0.00
2.9
4.4
1.56
1.49
%
0.11
14
131
16
155
1.03
0.00
1.1
1.5
—
—
—
0
0
17
166
1.03
0.00
2.7
6.4
23.43
24.09
mmol/l
0.20
17
160
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
8
88
0.91
-0.00
1.3
1.2
0.68
0.92
g/l
—
8
88
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
1.1
4.6
1163.57
1213.45
u/ml
—
7
65
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
14.29
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
1.18
—
0
7
5
58
0.86
-0.00
1.4
1.3
—
—
—
0
0
7
75
0.93
-0.00
1.3
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
15.36
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
99.57
—
0
7
0
5
0.00
-0.00
0.0
9.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_HALLUDEFORMOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_HALLUDEFORMOTH | 0.675 [0.54, 0.85] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.581 |
During the follow-up period (1.1.1998 — 31.12.2019), 85 out of 970 females with M13_HALLUDEFORMOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_HALLUDEFORMOTH | 0.93 [0.7, 1.24] | 0.625 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 341 males with M13_HALLUDEFORMOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_HALLUDEFORMOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.058% | 0.114% |
| 5 | 0.403% | 1.004% |
| 10 | 1.009% | 2.475% |
| 15 | 2.078% | 4.616% |
| 20 | 3.681% | 7.893% |
Relationships between endpoints
↥Index endpoint: M13_HALLUDEFORMOTH – Other deformity of hallux (acquired)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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