cartilage disease: Softening and degeneration of the CARTILAGE. Pathological processes involving the chondral tissue (CARTILAGE).
Other specified/unspecified disorders of bone/cartilage
DOID EFO Endpoint Browser PheWeb
M13_BONEDISNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1189 |
4. Check minimum number of eventsNone |
1189 |
5. Include endpointsNone |
1189 |
6. Filter based on genotype QC (FinnGen only) |
1081 |
Control definitions (FinnGen only)
- Control exclude
- M13_OSTEOCHONDRO
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other specified/unspecified disorders of bone/cartilage
based on the number of shared cases.
Similar with more cases:
- Other disorders of bone
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8627 | 3501 | 5069 |
| Only index persons | 7527 | 3030 | 4497 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.10 | 0.14 |
| Only index persons | 0.15 | 0.11 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 30.25 | 43.37 | 20.93 |
| Only index persons | 28.79 | 40.76 | 20.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1081 | 503 | 578 |
| Unadjusted period prevalence (%) | 0.22 | 0.18 | 0.27 |
| Median age at first event (years) | 33.10 | 43.21 | 24.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1101
- Matched controls
- 11010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
72398
ICD-8 Finland
Other diseases of bone, Alii definiti
+∞
307.7
353
*
M89.9
ICD-10 Finland
Disorder of bone, unspecified
+∞
188.0
175
*
M94.9
ICD-10 Finland
Disorder of cartilage, unspecified
1043.9
185.0
176
*
M94.8
ICD-10 Finland
Other specified disorders of cartilage
1331.4
124.5
119
*
72399
ICD-8 Finland
Other diseases of bone
+∞
110.3
104
*
7339X
ICD-9 Finland
Other disorders of bone and cartilage, Other and unspecified disorders of bone and cartilage
+∞
101.7
96
*
M89.88
ICD-10 Finland
Other specified disorders of bone, other
836.9
80.5
78
*
9102
FHL
Trepanation or removal of the local bone process
32.0
75.1
49
16
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
16.1
41.9
36
23
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
3.7
35.8
121
353
M81.9
ICD-10 Finland
Osteoporosis, unspecified
7.2
32.0
48
69
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
4.9
31.5
72
156
M89.0
ICD-10 Finland
Algoneurodystrophy
113.3
30.8
33
*
N02AX02
ATC
tramadol; systemic, rectal
1.9
25.4
520
3466
N03AX16
ATC
[U] pregabalin
2.1
23.2
279
1533
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.1
22.6
277
1531
M25.5
ICD-10 Finland
Pain in joint
1.9
22.0
413
2641
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
7.6
20.4
29
39
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.3
19.8
165
779
R51.80
ICD-10 Finland
Headache
2.2
19.2
197
1011
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
18.7
153
715
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
18.5
340
2135
M54.5
ICD-10 Finland
Low back pain
1.8
17.6
428
2915
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.2
17.4
161
792
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
2.2
17.1
161
796
H02AB06
ATC
prednisolone; systemic
1.7
16.9
523
3798
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
4.8
16.7
38
82
M79.6
ICD-10 Finland
Pain in limb
1.7
16.1
492
3546
M03BX02
ATC
tizanidine; oral
1.7
15.3
702
5605
M94.0
ICD-10 Finland
Chondrocostal junction syndrome [Tietze]
5.2
15.1
31
61
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
15.1
314
2028
N03AX12
ATC
[U] gabapentin; oral
2.0
15.1
189
1039
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.2
14.7
131
633
1220
FHL
Arthroscopy
3.1
14.5
62
209
M01AB05
ATC
diclofenac; systemic, rectal
1.7
14.5
735
5982
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
14.4
388
2683
M54.4
ICD-10 Finland
Lumbago with sciatica
1.9
14.4
222
1307
M01AH05
ATC
etoricoxib; oral
1.7
14.3
715
5787
N06AX21
ATC
duloxetine; oral
2.1
14.1
149
769
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
14.0
497
3682
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
13.6
512
3842
J01FF01
ATC
clindamycin; systemic
1.7
13.6
296
1929
M23.8
ICD-10 Finland
Other internal derangements of knee
3.2
13.2
54
177
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
13.2
484
3601
M77.4
ICD-10 Finland
Metatarsalgia
2.5
13.2
83
344
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.3
13.1
107
498
A03FA02
ATC
cisapride; oral, rectal
2.5
13.0
85
358
M02AA07
ATC
piroxicam; topical
1.6
13.0
384
2705
M01AE03
ATC
ketoprofen; systemic, rectal
1.6
12.9
396
2814
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.1
12.9
128
644
R03DC03
ATC
montelukast; oral
1.9
12.9
185
1061
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
4.6
12.9
30
66
L15
ICPC
Knee symptom/complaint
1.7
12.4
282
1851
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.2
12.4
115
564
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
2.1
12.3
124
627
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.0
12.3
147
792
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
2.7
12.2
68
265
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
12.1
328
2255
J01AA02
ATC
doxycycline; systemic
1.7
12.0
838
7202
WX002
NOMESCO Finland
Sedation and analgesia
1.8
11.8
199
1198
B01AB05
ATC
enoxaparin; parenteral
1.6
11.7
322
2219
R03AC02
ATC
salbutamol; inhalant
1.6
11.6
582
4609
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
11.5
215
1333
R02
ICPC
Shortness of breath/dyspnoea
1.9
11.5
147
811
M94.2
ICD-10 Finland
Chondromalacia
121.2
11.4
12
*
M01AH01
ATC
celecoxib; oral
1.8
11.4
196
1186
X58
ICD-10 Finland
Exposure to other specified factors
1.8
11.4
176
1032
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.6
11.3
68
276
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.3
11.3
86
389
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
11.1
236
1516
UJF32
NOMESCO Finland
Coloscopy
1.7
11.1
276
1848
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
11.1
126
667
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
2.0
10.9
124
656
A02BC01
ATC
omeprazole; systemic
1.6
10.5
272
1840
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
4.2
10.4
27
65
N06AX16
ATC
venlafaxine; oral
1.8
10.3
159
930
S60.2
ICD-10 Finland
Contusion of other parts of wrist and hand
2.5
10.3
64
264
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
10.3
303
2113
N02AA05
ATC
oxycodone; systemic
1.8
10.2
185
1136
NF1AA
NOMESCO Finland
Hip X-ray examination
2.1
10.0
94
463
M19.0
ICD-10 Finland
Primary arthrosis of other joints
1.9
10.0
128
705
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.0
9.9
111
583
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
16.9
9.9
15
9
N02BF01
ATC
gabapentin; oral
2.0
9.8
117
629
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
9.8
187
1165
L17
ICPC
Foot/toe symptom/complaint
1.6
9.8
313
2221
S93.2
ICD-10 Finland
Rupture of ligaments at ankle and foot level
4.2
9.7
25
60
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.8
9.6
49
183
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.2
9.5
82
390
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
15.2
9.5
15
10
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
9.5
243
1633
R42
ICD-10 Finland
Dizziness and giddiness
1.6
9.5
234
1559
M89.81
ICD-10 Finland
Other specified disorders of bone, shoulder region
+∞
9.4
9
*
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
8.1
9.4
20
25
J01MA02
ATC
ciprofloxacin; systemic
1.5
9.3
387
2901
N06AA09
ATC
amitriptyline; systemic
2.0
9.3
99
511
R07.3
ICD-10 Finland
Other chest pain
1.9
9.2
117
642
A02BC02
ATC
pantoprazole; systemic
1.5
9.1
716
6092
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
9.1
190
1210
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.2
9.0
75
352
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
3.5
9.0
30
87
M05BA06
ATC
ibandronic acid; systemic
4.4
8.9
22
51
L03
ICPC
Low back symptom/complaint
1.5
8.9
299
2139
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
8.9
426
3283
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
8.8
194
1254
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
8.8
226
1519
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.0
8.7
102
544
9476
FHL
Splitting of fascia or aponeurosis
6.7
8.7
21
32
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
8.7
247
1700
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
2.8
8.6
42
153
T92.3
ICD-10 Finland
Sequelae of dislocation, sprain and strain of upper limb
7.0
8.6
20
29
S29
ICPC
Skin symptom/complaint other
1.6
8.5
203
1337
A02BA02
ATC
ranitidine; systemic
1.7
8.5
192
1248
M93.2
ICD-10 Finland
Osteochondritis dissecans
90.7
8.4
9
*
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
3.3
8.4
31
96
A02BC05
ATC
esomeprazole; systemic
1.5
8.4
416
3218
L28
ICPC
Limited function/disability (L)
1.7
8.2
173
1104
M01AX17
ATC
nimesulide; oral
1.6
8.2
233
1601
R06AE07
ATC
cetirizine; oral
1.5
8.1
426
3328
W00
ICD-10 Finland
Fall on same level involving ice and snow
1.8
8.0
120
694
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
2.4
8.0
54
232
R06.0
ICD-10 Finland
Dyspnoea
1.5
7.9
270
1930
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
13.1
7.9
13
10
UKC02
NOMESCO Finland
Cystoscopy
1.7
7.9
151
939
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
7.8
148
916
H02AB07
ATC
prednisone; oral
1.8
7.8
131
785
M22.4
ICD-10 Finland
Chondromalacia patellae
2.9
7.7
36
128
H02AB04
ATC
methylprednisolone; systemic
1.7
7.7
144
888
M77.1
ICD-10 Finland
Lateral epicondylitis
1.9
7.7
97
531
AA1AD
NOMESCO Finland
CT of head and brain
1.5
7.6
285
2075
NDA30
NOMESCO Finland
Exploration of joint of wrist or hand, arthroscopic
8.1
7.6
16
20
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.0
7.6
82
426
M01AE02
ATC
naproxen; oral, rectal
1.4
7.6
586
4890
E0000UV, ,
ATC
1.4
7.6
404
3152
M01AX05
ATC
glucosamine; oral
1.6
7.6
182
1199
M84.1
ICD-10 Finland
Nonunion of fracture [pseudarthrosis]
25.2
7.6
10
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.9
7.6
91
491
R96
ICPC
Asthma
1.9
7.5
100
557
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
7.5
369
2833
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.8
7.5
105
595
ND1AA
NOMESCO Finland
Wrist X-ray examination
2.1
7.5
75
379
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
2.0
7.5
77
393
9101
FHL
Bone biopsy
80.6
7.4
8
*
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
80.6
7.4
8
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.6
7.4
163
1050
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
3.0
7.4
31
104
M01AB55
ATC
diclofenac, combinations; oral
2.1
7.4
66
320
KH1AD
NOMESCO Finland
CT of urinary organs
2.5
7.3
44
179
M01AH02
ATC
rofecoxib; oral
1.7
7.3
125
752
R03BA01
ATC
beclometasone; inhalant
1.7
7.3
138
855
ZXA05
NOMESCO Finland
Left side
1.5
7.3
232
1632
M05BA04
ATC
alendronic acid; oral
2.2
7.2
63
302
L29
ICPC
Musculoskeletal sympt/complt other
1.9
7.2
88
477
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
2.3
7.2
55
250
WX320
NOMESCO Finland
Spinalanesthesy
1.5
7.0
237
1686
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
3.4
7.0
24
71
R03BA08
ATC
ciclesonide; inhalant
1.9
7.0
91
504
N02BF02
ATC
pregabalin; oral
2.0
7.0
73
375
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
6.9
109
641
M09AX01
ATC
hyaluronic acid; parenteral
2.4
6.9
47
203
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.7
6.9
130
805
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
6.8
101
582
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.6
6.8
150
967
S18
ICPC
Laceration/cut
1.4
6.8
474
3861
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.5
6.7
278
2059
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
6.7
403
3196
R04.0
ICD-10 Finland
Epistaxis
1.9
6.7
79
424
R03BA05
ATC
fluticasone; inhalant
1.6
6.6
175
1177
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
6.6
500
4120
N02BE01
ATC
paracetamol; systemic, rectal
1.6
6.6
945
8723
J01DB01
ATC
cefalexin; oral
1.5
6.6
866
7849
SPAT1229
SPAT
Assessment of need for aid
2.0
6.6
67
341
J01FA06
ATC
roxithromycin; oral
1.4
6.6
390
3084
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
1.7
6.6
123
759
R52.9
ICD-10 Finland
Pain, unspecified
1.8
6.6
105
620
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.9
6.5
85
471
NH3BA, ,
SPAT
3.1
6.5
27
90
N06AX11
ATC
mirtazapine; oral
1.4
6.5
340
2628
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
6.5
119
730
M05BX04
ATC
denosumab; parenteral
2.4
6.5
45
196
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.1
6.5
61
302
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.2
6.4
24
75
Y0899
ICD-8 Finland
Investigation of musculoskeletal system
7.4
6.4
14
19
SPAT1312
SPAT
General health counselling
1.4
6.4
293
2210
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
6.4
132
837
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
3.1
6.3
25
81
J02AC01
ATC
fluconazole; systemic
1.4
6.3
340
2639
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
6.3
188
1299
M79.7
ICD-10 Finland
Fibromyalgia
2.5
6.3
37
149
N03AX09
ATC
lamotrigine; oral
2.2
6.3
51
238
M87.0
ICD-10 Finland
Idiopathic aseptic necrosis of bone
+∞
6.3
6
*
M88.9
ICD-10 Finland
Paget disease of bone, unspecified
+∞
6.3
6
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
6.2
173
1177
WZA90
NOMESCO Finland
Other medical or dental certificate
1.5
6.2
231
1673
R07.2
ICD-10 Finland
Precordial pain
3.0
6.2
27
93
J45.1
ICD-10 Finland
Nonallergic asthma
1.9
6.2
71
378
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
5.8
6.2
16
28
R52.2
ICD-10 Finland
Other chronic pain
2.3
6.1
43
189
L18
ICPC
Muscle pain
2.3
6.1
43
189
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
6.1
86
490
NH1BA, ,
SPAT
3.1
6.1
24
78
ZXA00
NOMESCO Finland
Right side
1.5
6.1
244
1794
SPAT1211
SPAT
Application of soft bandage
1.9
6.0
79
439
JN4AD
NOMESCO Finland
Body CT examination
1.7
6.0
114
706
C07AB07
ATC
bisoprolol; oral
1.4
6.0
471
3887
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.7
6.0
99
590
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
2.2
6.0
50
236
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
544
4087
1.65
14.79
9.0
6.4
1.21
1.21
mmol/l
0.33
506
3790
534
4062
1.61
13.31
5.6
5.1
36.10
35.97
g/l
0.21
503
3829
417
3020
1.61
12.52
3.3
2.7
58.82
62.27
u/l
0.38
393
2821
619
4939
1.58
12.16
6.9
6.7
11.26
11.62
umol/l
0.25
599
4731
536
4142
1.57
12.08
3.0
2.3
76.19
75.88
nmol/l
0.10
477
3759
580
4564
1.57
12.07
10.1
7.0
1.21
1.21
mmol/l
0.27
499
3977
556
4357
1.56
11.62
12.5
13.6
1.20
1.22
inr
0.41
474
3602
839
7255
1.66
11.26
9.8
8.0
77.22
77.96
u/l
0.20
807
6910
812
6992
1.61
10.79
5.5
4.2
11.48
11.17
mm/h
0.27
772
6556
67
276
2.52
10.77
3.2
3.6
26.73
41.59
mg/l
1.22
59
233
124
661
1.99
10.66
1.7
1.6
—
—
—
0
0
227
1466
1.69
10.44
3.1
2.4
2.28
2.34
g/l
0.93
216
1374
66
276
2.48
10.29
3.2
3.6
39.33
62.88
mg/l
0.54
58
234
212
1350
1.71
10.25
3.1
2.5
24.82
23.49
%
0.69
202
1279
652
5394
1.51
9.92
9.6
9.7
4.07
4.10
e9/l
0.09
580
4689
236
1569
1.64
9.63
3.1
2.5
14.05
13.52
umol/l
0.50
225
1479
473
3696
1.49
9.30
5.2
3.6
31.44
69.95
ng/l
1.27
350
2592
192
1220
1.69
9.30
6.8
6.0
1.05
1.03
mmol/l
0.29
178
1141
60
253
2.45
9.21
3.2
3.3
1.90
2.07
ratio
0.11
35
139
125
708
1.86
8.95
2.8
2.7
66.63
66.82
g/l
0.10
114
672
541
4386
1.46
8.59
2.9
2.7
—
—
estimate
—
0
0
189
1221
1.66
8.56
2.9
2.5
128.11
127.68
ug/g
0.01
148
1001
79
392
2.09
8.27
1.5
1.6
4.21
5.25
iu/ml
0.22
18
84
271
1923
1.54
8.26
1.6
1.4
2.38
2.50
g/l
0.54
177
1226
144
879
1.73
8.02
2.4
2.2
361.99
380.34
nmol/l
0.59
128
821
664
5651
1.44
7.81
6.4
5.1
6.71
6.72
mmol/l
0.04
644
5362
15
16
9.49
7.79
2.1
1.9
81.80
60.11
ug/l
0.51
15
16
111
644
1.80
7.35
4.8
3.9
81.98
83.78
ng/l
0.09
91
570
282
2068
1.49
7.24
2.9
2.6
5.51
5.26
e6/l
0.10
255
1892
690
5965
1.42
7.10
5.7
4.3
1579.86
2042.68
e6/l
—
7
94
63
308
2.11
6.88
1.5
1.5
266.13
269.23
ug/g
0.04
41
187
337
2583
1.44
6.82
3.1
2.7
354.89
349.63
umol/l
0.43
303
2322
290
2162
1.46
6.79
1.8
1.7
1.19
1.13
mg/l
0.10
223
1684
211
1492
1.51
6.38
2.3
1.9
—
—
—
0
0
241
1762
1.47
6.17
1.4
1.3
20.39
30.95
iu/ml
1.28
75
546
122
766
1.67
6.12
2.6
2.5
10.19
10.71
g/l
0.81
112
714
223
1610
1.48
6.08
3.7
3.5
0.81
0.82
mmol/l
0.52
207
1538
383
3052
1.39
6.07
4.2
3.2
27.81
80.21
e6/l
1.57
301
2314
117
731
1.67
5.98
1.3
1.5
—
—
—
0
0
281
2130
1.43
5.92
1.4
1.3
0.94
1.31
u/ml
0.57
74
594
332
2597
1.40
5.83
3.9
3.1
0.31
0.41
e6/l
0.59
250
1870
993
9335
1.65
5.76
20.5
14.6
21.22
24.17
mg/l
2.46
853
7665
72
399
1.86
5.56
1.7
1.9
1.51
1.56
g/l
0.20
60
355
53
266
2.04
5.45
1.2
1.3
—
—
—
0
0
309
2411
1.39
5.45
4.7
4.0
90.92
90.49
%
0.11
297
2369
54
273
2.03
5.45
1.3
1.2
4.68
2.65
u/ml
—
6
25
590
5090
1.34
5.44
4.9
3.6
0.02
0.01
estimate
0.16
130
975
65
358
1.87
5.14
2.8
2.1
6.93
7.27
g/l
0.98
58
338
65
358
1.87
5.14
2.8
2.1
3.44
3.74
g/l
0.96
58
338
65
358
1.87
5.14
2.8
2.1
4.01
4.27
g/l
1.76
58
338
154
1065
1.52
5.14
8.0
6.5
—
—
—
0
0
350
2810
1.36
5.13
3.6
3.0
1017.34
1102.38
ng/l
0.23
305
2383
53
274
1.98
5.05
1.3
1.2
3.02
8.93
u/ml
—
6
37
53
275
1.97
5.00
1.3
1.3
—
—
—
0
0
61
334
1.87
4.92
2.2
2.2
2.68
2.89
g/l
1.06
54
314
368
2995
1.34
4.89
2.5
2.2
238.01
249.29
u/l
0.04
349
2853
45
223
2.06
4.82
1.2
1.1
14.60
43.23
u/ml
—
6
20
13
26
5.05
4.64
3.1
4.3
—
—
—
0
0
150
1054
1.49
4.63
4.4
4.6
237.43
240.80
u/l
0.16
142
1006
327
2632
1.34
4.63
1.9
1.7
20.73
20.32
nmol/l
0.17
274
2258
218
1647
1.40
4.57
1.6
1.5
—
—
—
0
0
287
2269
1.36
4.56
2.6
2.4
—
—
—
0
0
56
306
1.87
4.56
2.7
2.1
9.58
10.53
g/l
0.77
48
285
574
5008
1.31
4.55
4.8
3.5
0.00
0.00
estimate
0.50
132
1045
967
9137
1.48
4.34
19.1
14.1
81.84
82.57
ml/min/173m2
0.52
903
8457
156
1120
1.46
4.32
5.6
4.9
31.35
31.48
%
0.05
106
751
42
212
2.02
4.31
1.4
1.5
—
—
—
0
0
339
2769
1.32
4.29
5.0
3.7
0.00
0.01
estimate
0.88
124
979
219
1674
1.38
4.27
1.4
1.3
2.15
10.88
u/ml
5.93
80
656
513
4436
1.29
4.24
3.7
3.0
139.10
140.11
ug/l
0.03
483
4159
54
299
1.85
4.24
2.1
2.2
0.84
0.96
g/l
0.10
47
274
408
3425
1.30
4.22
3.8
3.3
8.05
8.14
mmol/l
0.13
338
2931
576
5058
1.29
4.22
4.8
3.6
9.91
4.99
estimate
0.20
137
1054
58
329
1.81
4.22
1.7
1.5
—
—
—
0
0
374
3105
1.31
4.19
3.2
3.4
2.35
2.35
mmol/l
0.30
340
2841
154
1110
1.45
4.18
2.0
1.8
—
—
—
0
0
52
286
1.86
4.17
1.4
1.4
7.66
8.56
u/l
0.27
39
230
128
891
1.49
4.14
2.1
2.4
0.21
0.22
g/l
0.59
116
846
83
525
1.63
4.09
1.9
1.6
—
—
—
0
0
197
1490
1.39
4.08
1.9
2.0
29.99
29.40
s
0.42
189
1449
41
211
1.98
4.01
1.2
1.3
232.16
1107.34
e6/l
0.66
32
152
132
931
1.47
4.01
5.8
3.5
1.26
1.92
mmol/l
0.99
117
803
742
6762
1.30
3.95
3.8
3.4
45.34
50.37
u/l
1.31
701
6422
655
5875
1.28
3.94
3.1
2.9
—
—
—
0
0
55
315
1.79
3.90
1.7
1.5
0.04
0.25
iu/ml
—
10
48
450
3859
1.28
3.86
4.7
3.5
0.03
0.02
estimate
0.11
108
876
146
1058
1.44
3.85
2.0
1.8
—
—
—
0
0
19
71
2.71
3.84
1.0
1.0
—
—
—
0
0
190
1444
1.38
3.82
1.8
1.7
1166.06
1171.13
nmol/l
0.03
134
1089
23
95
2.45
3.82
2.3
2.4
33.43
20.21
mg/l
—
7
44
125
883
1.47
3.77
9.8
7.8
1.50
1.40
mmol/l
0.41
125
868
70
434
1.65
3.75
2.2
2.1
38.84
39.50
u/l
0.09
57
389
34
168
2.06
3.73
2.6
3.8
8.33
8.86
pmol/l
0.10
34
168
40
210
1.94
3.72
1.2
1.2
6.43
9.58
e6/l
0.27
30
144
83
540
1.58
3.67
3.9
3.1
1.68
1.76
mmol/l
0.05
66
394
474
4110
1.27
3.67
2.5
2.1
96.48
95.41
pmol/l
0.19
255
2223
76
486
1.61
3.61
1.8
1.8
0.21
0.37
mg/l
2.47
30
248
146
1071
1.42
3.61
2.5
2.9
8.50
8.26
umol/l
0.04
124
951
273
2219
1.31
3.49
4.9
3.5
1.02
1.02
kg/l
0.30
183
1490
72
461
1.60
3.42
1.1
1.1
—
—
—
0
0
1001
9600
1.47
3.36
24.1
17.1
139.56
139.71
mmol/l
1.17
987
9424
781
7225
1.28
3.36
4.9
4.1
14.82
14.72
pmol/l
0.53
710
6659
1003
9624
1.47
3.35
24.1
17.3
3.99
3.98
mmol/l
0.35
988
9431
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
48
278
1.76
3.31
3.4
2.6
0.32
0.35
iu/ml
0.27
27
152
23
104
2.24
3.17
1.7
1.8
—
—
—
0
0
80
535
1.53
3.17
4.8
2.5
1.35
1.26
%
0.30
80
530
17
67
2.56
3.13
1.0
1.0
908.00
684.21
ng/l
1.19
12
43
17
67
2.56
3.13
1.0
1.0
303.58
249.27
ng/l
0.67
12
44
17
67
2.56
3.13
1.0
1.0
42.55
32.50
ng/l
0.74
12
42
284
2355
1.28
3.07
2.9
2.2
2.85
2.86
mg/l
0.03
249
2026
19
80
2.40
3.07
1.3
1.7
—
—
—
0
0
150
1138
1.37
3.05
3.1
2.3
13.42
13.82
nmol/l
0.30
134
1057
43
249
1.76
3.00
1.9
2.1
0.00
0.00
g/l
-0.00
38
226
947
9033
1.35
2.95
7.1
6.2
39.42
39.31
mmol/mol
0.15
880
8553
98
695
1.45
2.93
2.5
2.5
12.39
18.52
au/ml
0.56
11
75
21
95
2.23
2.91
1.8
1.9
—
—
—
0
0
912
8658
1.31
2.89
6.1
5.0
1.84
1.90
mu/l
0.62
838
8047
108
784
1.42
2.86
2.9
2.7
66.61
68.69
ml/min/173m2
0.27
47
330
42
250
1.71
2.69
1.7
1.7
—
—
—
0
0
1034
10034
1.50
2.68
25.9
19.0
80.60
78.00
umol/l
1.42
1025
9931
43
258
1.69
2.67
2.0
2.2
13.12
11.92
mg/l
0.47
37
246
52
329
1.61
2.65
2.2
1.9
—
—
—
0
0
71
484
1.50
2.61
1.3
1.4
—
—
—
0
0
201
1631
1.28
2.56
3.7
2.8
0.78
0.97
e6/l
0.94
116
850
377
3286
1.22
2.56
4.5
4.1
12.62
7.69
mg/mmol
0.43
238
2109
12
44
2.75
2.55
1.5
1.5
—
—
—
0
0
12
44
2.75
2.55
1.5
1.5
—
—
—
0
0
14
56
2.52
2.53
1.4
1.5
—
—
—
0
0
14
56
2.52
2.53
1.4
1.5
—
—
—
0
0
39
232
1.71
2.52
2.9
3.0
2.30
2.01
index
0.13
23
126
9
26
3.48
2.48
1.6
2.3
—
—
—
0
0
9
26
3.48
2.48
1.6
2.3
—
—
—
0
0
11
38
2.91
2.41
1.5
2.1
—
—
—
0
0
11
38
2.91
2.41
1.5
2.1
—
—
—
0
0
11
38
2.91
2.41
1.5
2.1
—
—
—
0
0
11
38
2.91
2.41
1.5
2.1
—
—
—
0
0
23
117
1.99
2.41
1.4
1.4
—
—
—
0
0
29
160
1.83
2.41
1.7
1.8
—
—
—
0
0
9
27
3.35
2.39
1.7
2.3
—
—
—
0
0
14
58
2.43
2.37
1.1
1.1
101.07
103.16
pmol/l
0.07
14
58
37
221
1.70
2.37
1.4
1.5
—
—
—
0
0
105
786
1.37
2.35
2.5
2.3
6.08
8.16
ug/l
0.73
82
712
40
245
1.66
2.34
1.6
1.6
—
—
—
0
0
43
269
1.62
2.32
1.5
1.4
—
—
—
0
0
48
309
1.58
2.31
2.0
1.8
—
—
—
0
0
20
99
2.04
2.27
1.4
1.3
7827.00
229120.32
e6/l
1.46
11
69
22
113
1.97
2.26
1.4
1.5
—
—
—
0
0
22
113
1.97
2.26
1.4
1.5
—
—
—
0
0
22
114
1.95
2.21
1.4
1.5
—
—
—
0
0
22
114
1.95
2.21
1.3
1.3
—
—
—
0
0
11
41
2.70
2.21
1.0
1.3
—
—
—
0
0
120
928
1.33
2.19
3.6
3.3
—
—
—
0
0
33
196
1.70
2.17
1.3
1.5
—
—
—
0
0
116
894
1.33
2.17
3.0
2.6
32.74
42.62
u/l
0.96
100
767
20
101
2.00
2.16
1.1
1.0
—
—
—
0
0
16
74
2.18
2.15
1.0
1.1
218.82
286.39
mg/l
1.22
11
69
50
332
1.53
2.12
4.4
3.2
24.58
24.90
mmol/l
0.29
50
313
22
117
1.90
2.07
1.4
1.4
—
—
—
0
0
22
118
1.88
2.02
4.7
6.4
11.34
11.66
mg/l
0.15
22
109
19
97
1.98
2.01
1.1
1.2
—
—
—
0
0
83
616
1.38
1.99
1.2
1.2
113.63
138.14
u/ml
0.20
31
238
210
1765
1.23
1.98
3.0
3.0
2.45
2.45
mmol/l
0.14
186
1582
219
1849
1.23
1.98
4.7
3.8
504.17
499.36
ng/l
0.01
161
1434
24
134
1.81
1.96
1.5
1.3
—
—
—
0
0
17
84
2.04
1.96
1.5
1.7
—
—
—
0
0
17
84
2.04
1.96
1.5
1.7
—
—
—
0
0
17
84
2.04
1.96
1.5
1.7
—
—
—
0
0
74
541
1.39
1.95
4.4
3.4
4.41
4.55
pmol/l
0.65
68
476
85
636
1.36
1.95
1.4
1.3
32.23
51.39
au/ml
—
7
49
224
1902
1.22
1.92
1.9
1.7
33690258.18
33167198.66
pmol/l
0.01
187
1601
32
196
1.65
1.91
1.1
1.1
3.66
1.75
u/ml
0.59
16
109
136
1092
1.28
1.90
10.4
8.6
0.64
0.84
mmol/l
0.22
119
915
81
606
1.36
1.86
4.9
2.9
129.44
131.61
g/l
0.35
81
594
21
115
1.84
1.83
1.4
1.4
—
—
—
0
0
179
1492
1.24
1.83
4.3
3.0
2.61
2.33
e6/l
0.12
93
719
369
3297
1.18
1.81
3.5
3.3
30.39
32.64
u/l
0.97
347
3128
22
123
1.80
1.81
1.0
1.1
—
—
—
0
0
1020
9950
1.34
1.79
14.8
11.6
27.74
27.54
u/l
0.12
1000
9703
5
13
3.86
1.71
1.4
1.0
—
—
—
0
0
44
302
1.48
1.65
2.5
2.6
—
—
—
0
0
6
147
0.40
1.65
1.7
1.7
—
—
—
0
0
26
159
1.65
1.60
1.1
1.1
1.59
1.80
u/ml
—
9
79
163
1369
1.22
1.57
2.0
1.9
1.48
1.48
%
0.04
133
1211
25
153
1.65
1.54
1.5
1.4
—
—
—
0
0
7
27
2.60
1.51
1.1
1.3
—
—
—
0
0
11
51
2.17
1.51
1.5
1.9
—
—
—
0
0
15
79
1.91
1.50
1.5
1.9
16.87
21.68
nmol/l
2.12
15
74
5
16
3.13
1.44
1.0
1.0
—
—
—
0
0
5
16
3.13
1.44
1.0
1.0
—
—
—
0
0
29
189
1.55
1.41
1.5
1.4
—
—
—
0
0
16
89
1.81
1.37
1.4
1.5
169.16
279.27
pmol/l
0.53
16
89
940
9131
1.20
1.37
5.6
5.1
6.00
5.97
mmol/l
0.17
859
8483
6
23
2.62
1.37
1.3
1.3
—
—
—
0
0
15
82
1.84
1.36
1.0
1.1
—
—
—
0
0
25
159
1.59
1.35
1.2
1.1
1.00
43.71
iu/ml
—
6
33
64
489
1.33
1.34
6.0
3.7
50.86
48.84
%
0.26
64
479
10
195
0.51
1.34
1.8
1.3
165.30
259.00
pmol/l
—
10
190
38
266
1.44
1.33
1.9
2.3
1688.55
4513.51
u/l
0.71
13
107
16
90
1.79
1.33
1.1
1.1
—
—
—
0
0
12
61
1.98
1.33
1.0
1.1
—
—
—
0
0
19
113
1.69
1.32
1.4
1.1
—
—
—
0
0
115
950
1.24
1.31
4.0
4.4
11.06
15.14
ug/l
0.22
95
777
87
696
1.27
1.31
5.1
3.8
1.22
1.23
mmol/l
0.79
78
600
9
43
2.10
1.30
1.2
1.5
—
—
—
0
0
9
43
2.10
1.30
1.2
1.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
11
55
2.01
1.27
1.0
1.1
—
—
—
0
0
19
115
1.66
1.25
1.6
1.6
75.58
61.34
%
1.02
12
77
308
2789
1.14
1.22
4.0
3.1
0.01
0.02
estimate
0.25
110
837
10
50
2.01
1.16
1.7
1.8
102.84
125.82
ng/l
—
10
50
5
20
2.51
1.15
1.0
1.2
—
—
—
0
0
33
233
1.43
1.14
3.5
2.3
130.22
132.04
g/l
0.19
27
193
14
80
1.76
1.13
1.1
1.2
—
—
—
0
0
1043
10273
1.29
1.10
30.6
22.5
249.88
247.68
e9/l
0.54
1031
10087
7
31
2.27
1.10
1.0
1.1
—
—
—
0
0
45
338
1.35
1.10
1.8
1.6
21.22
12.15
u/ml
—
5
82
460
4298
1.12
1.09
2.1
1.9
1.40
1.41
mmol/l
0.06
391
3671
5
21
2.39
1.09
1.4
1.2
—
—
—
0
0
1043
10275
1.29
1.08
30.5
22.4
91.26
91.05
fl
0.84
1036
10179
10
52
1.93
1.06
1.8
3.0
1936.50
1214.65
u/ml
—
10
52
19
121
1.58
1.06
1.4
1.6
—
—
—
0
0
1043
10278
1.28
1.05
31.4
22.9
40.82
40.99
%
0.52
1036
10175
1043
10278
1.28
1.05
30.6
22.4
4.52
4.56
e12/l
1.63
1029
10063
14
82
1.72
1.05
1.1
1.1
—
—
—
0
0
1043
10279
1.28
1.04
30.6
22.5
6.77
6.71
e9/l
0.27
1029
10060
34
246
1.39
1.04
2.0
1.7
—
—
—
0
0
7
34
2.07
1.03
1.0
1.1
—
—
—
0
0
59
466
1.28
1.02
1.3
1.3
—
—
—
0
0
36
265
1.37
1.01
1.9
1.6
9579.37
12274.60
e6/l
0.28
27
186
1043
10283
1.27
1.01
30.8
22.6
136.51
137.63
g/l
1.64
1036
10185
28
197
1.43
1.00
2.0
1.7
—
—
—
0
0
13
76
1.72
0.99
1.3
1.1
—
43.20
—
0
5
14
84
1.68
0.98
1.1
1.1
—
—
—
0
0
14
84
1.68
0.98
1.1
1.1
—
—
—
0
0
18
116
1.56
0.97
1.6
2.4
33.72
32.92
pg
0.38
18
116
10
54
1.86
0.96
3.4
3.3
0.50
0.96
index
—
10
54
14
85
1.66
0.94
4.5
2.6
—
—
—
0
0
48
374
1.30
0.94
1.6
1.8
5.94
5.11
mg/l
0.10
35
285
16
101
1.59
0.94
1.3
1.2
—
—
—
0
0
10
55
1.83
0.92
1.1
1.9
—
—
—
0
0
14
86
1.64
0.91
1.2
1.3
—
—
—
0
0
815
7904
1.12
0.91
23.4
18.3
13.73
13.57
%
2.44
805
7802
35
262
1.35
0.90
1.3
1.1
2.60
3.89
—
5
41
17
111
1.54
0.88
1.6
1.5
20.45
26.53
ng/l
0.78
17
111
10
56
1.79
0.88
1.5
1.4
—
—
—
0
0
14
87
1.62
0.87
1.3
2.2
3.79
5.32
umol/l
—
7
62
11
64
1.73
0.86
1.4
1.2
—
—
—
0
0
6
32
1.88
0.82
1.0
1.1
—
—
—
0
0
6
32
1.88
0.82
1.0
1.1
—
—
—
0
0
22
155
1.43
0.81
1.1
1.1
—
—
—
0
0
12
188
0.63
0.80
1.6
1.4
—
—
—
0
0
6
33
1.82
0.79
2.0
2.0
—
—
—
0
0
6
33
1.82
0.79
1.0
1.1
—
—
—
0
0
19
131
1.46
0.78
1.3
1.6
—
—
—
0
0
9
53
1.70
0.75
1.6
1.5
—
—
—
0
0
415
3923
1.09
0.73
5.4
4.8
1.85
2.20
ug/l
1.16
380
3601
7
39
1.80
0.72
1.9
1.1
4.43
5.43
umol/l
—
7
30
7
39
1.80
0.72
1.3
1.0
—
—
—
0
0
5
26
1.93
0.70
3.4
3.1
4.60
5.61
ug/l
—
5
26
11
69
1.60
0.68
1.5
1.5
—
—
—
0
0
7
42
1.67
0.68
1.3
1.3
—
—
—
0
0
21
153
1.38
0.67
1.4
1.2
—
—
—
0
0
21
153
1.38
0.67
1.4
1.2
—
—
—
0
0
25
188
1.34
0.66
1.2
1.2
22.88
29.07
u/l
0.27
19
160
76
653
1.18
0.66
2.3
3.0
135.84
181.00
ng/l
0.59
71
591
5
29
1.73
0.64
5.0
3.0
10.22
10.02
kpa
—
5
29
5
29
1.73
0.64
5.0
3.0
5.76
4.71
kpa
—
5
29
51
424
1.21
0.63
1.9
2.9
37.87
55.74
u/ml
0.51
51
409
8
49
1.64
0.62
1.0
1.3
—
46.67
—
0
6
9
140
0.64
0.60
1.7
1.5
—
—
—
0
0
13
186
0.70
0.60
4.0
3.3
23.14
29.85
mg/l
—
7
128
25
192
1.31
0.59
1.2
1.5
168.86
157.52
au/ml
—
7
60
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
11
72
1.53
0.59
1.3
1.1
—
—
—
0
0
10
64
1.57
0.58
1.5
1.4
—
—
—
0
0
6
35
1.72
0.57
1.0
1.2
—
—
—
0
0
6
35
1.72
0.57
1.8
1.4
8.54
8.74
ug/l
—
6
35
11
73
1.51
0.56
4.2
3.4
19.76
88.61
u/ml
1.31
11
73
18
133
1.36
0.55
1.1
1.1
—
—
—
0
0
19
142
1.34
0.54
2.8
2.8
13.40
13.19
%
0.44
19
142
6
38
1.58
0.54
1.3
1.8
39.85
41.94
g/l
—
6
38
6
38
1.58
0.54
1.0
1.6
—
—
—
0
0
11
74
1.49
0.53
1.3
1.1
—
—
—
0
0
31
251
1.24
0.51
1.4
1.9
3.64
27.30
iu/l
—
10
99
25
199
1.26
0.48
1.2
1.2
342.11
248.43
u/ml
0.49
18
117
7
48
1.46
0.47
1.0
1.1
—
—
—
0
0
34
282
1.21
0.46
1.5
1.3
—
—
—
0
0
22
275
0.80
0.45
1.4
1.5
—
—
—
0
0
99
897
1.11
0.44
1.8
1.9
—
—
—
0
0
49
423
1.17
0.44
1.6
1.3
24.93
26.12
iu/l
0.09
42
354
9
128
0.70
0.43
1.1
1.8
—
—
—
0
0
5
31
1.62
0.43
1.6
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
1.18
—
0
16
0
17
0.00
0.40
0.0
1.1
—
0.71
—
0
12
0
17
0.00
0.40
0.0
2.8
—
8.54
—
0
8
0
17
0.00
0.40
0.0
1.1
—
0.86
—
0
9
5
34
1.47
0.40
4.2
3.7
32.88
34.14
umol/l
—
5
25
8
60
1.34
0.40
1.4
1.1
—
—
—
0
0
5
35
1.43
0.39
1.2
1.1
—
—
—
0
0
7
106
0.66
0.39
1.6
1.6
64.79
49.93
ug/l
—
7
106
5
36
1.39
0.38
5.0
2.6
50.00
47.90
umol/l
—
5
30
12
89
1.35
0.38
1.4
1.5
—
—
—
0
0
82
900
0.90
0.36
1.5
1.8
3.48
3.44
mmol/l
0.12
62
670
31
263
1.18
0.36
1.2
1.2
—
—
—
0
0
31
264
1.18
0.35
1.2
1.2
—
—
—
0
0
6
45
1.34
0.33
1.3
1.3
—
—
—
0
0
256
2450
1.06
0.33
3.3
3.0
0.75
0.71
ug/l
0.28
150
1479
22
183
1.21
0.32
1.5
1.5
—
—
—
0
0
7
52
1.35
0.31
1.9
3.8
1.43
1.07
%
—
7
52
7
53
1.32
0.31
1.0
1.2
—
—
—
0
0
331
3198
1.05
0.30
4.1
4.0
21.11
21.28
%
0.06
155
1443
7
55
1.27
0.30
9.6
7.6
31.71
348.54
ug/l
—
7
34
7
56
1.25
0.29
2.1
2.8
158.29
202.16
u/l
—
7
56
15
121
1.24
0.28
1.3
1.3
0.90
15.66
nmol/l
0.48
15
113
33
291
1.14
0.26
1.6
1.3
—
—
—
0
0
5
42
1.19
0.21
1.6
1.1
153.96
223.01
iu/ml
—
5
42
0
10
0.00
0.21
0.0
3.9
—
48.77
—
0
10
0
12
0.00
0.21
0.0
1.0
—
0.01
—
0
5
0
12
0.00
0.21
0.0
1.0
—
0.06
—
0
5
18
154
1.17
0.21
1.3
1.2
12.25
4.88
u/ml
—
8
65
0
14
0.00
0.20
0.0
1.1
—
27.78
—
0
9
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
12
100
1.20
0.18
1.1
1.2
—
—
—
0
0
965
9596
1.05
0.17
6.3
5.8
2.69
2.73
mmol/l
0.87
889
9016
42
453
0.92
0.16
1.1
1.2
0.87
0.89
g/l
0.27
42
453
103
986
1.05
0.16
1.9
2.0
—
—
—
0
0
7
88
0.79
0.14
1.0
1.0
—
—
—
0
0
25
227
1.10
0.14
1.4
1.2
—
—
—
0
0
907
9018
1.03
0.14
4.8
4.3
1.37
1.33
mmol/l
0.59
830
8404
24
218
1.10
0.13
2.4
2.3
14.29
123.34
ug/min
1.84
15
125
123
1188
1.04
0.13
1.5
1.5
—
—
—
0
0
117
1210
0.96
0.12
1.9
2.1
3.60
3.54
ratio
0.20
97
984
952
9478
1.03
0.12
5.7
5.2
4.58
4.64
mmol/l
1.00
888
8948
25
230
1.09
0.11
4.9
3.2
1.73
1.57
mmol/l
0.38
25
225
13
146
0.89
0.10
1.1
1.0
—
—
—
0
0
5
48
1.04
0.09
1.0
1.0
1797.60
1485.50
miu/ml
—
5
48
41
391
1.05
0.08
3.6
3.4
43.82
1214.61
u/ml
1.69
34
334
26
244
1.07
0.08
1.5
1.4
—
—
—
0
0
42
439
0.96
0.07
1.1
1.1
1.51
1.52
g/l
0.09
42
439
42
439
0.96
0.07
2.0
1.8
—
—
—
0
0
19
176
1.08
0.07
1.2
1.1
3.53
17.71
au/ml
—
6
47
8
90
0.89
0.06
2.5
3.6
—
—
—
0
0
13
120
1.08
0.05
1.1
1.1
106.00
99.47
%
0.33
13
112
50
509
0.98
0.02
2.1
1.9
—
—
—
0
0
944
9448
0.99
0.01
5.7
5.1
1.40
1.42
mmol/l
1.35
874
8867
29
286
1.01
0.00
1.3
1.4
93.41
240.38
miu/ml
3.41
14
135
10
101
0.99
0.00
1.1
1.2
—
—
—
0
0
18
177
1.02
0.00
2.6
1.5
—
—
—
0
0
19
193
0.98
0.00
6.0
3.4
7.04
7.62
mmol/l
0.66
19
188
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1.47
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
7.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.01
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
-0.00
1.8
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
1.2
1.2
16.00
8.89
mm/h
—
5
53
5
55
0.91
-0.00
1.2
1.1
10.80
11.36
u/l
—
5
50
6
62
0.97
-0.00
1.7
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
7.3
—
412.33
—
0
6
0
9
0.00
-0.00
0.0
2.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_BONEDISNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONEDISNAS | 1.434 [1.18, 1.74] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.203 |
During the follow-up period (1.1.1998 — 31.12.2019), 217 out of 1536 females with M13_BONEDISNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONEDISNAS | 1.396 [1.14, 1.7] | 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 149 out of 1231 males with M13_BONEDISNAS died.
Mortality risk
Mortality risk for people of age
years, who have M13_BONEDISNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.111% | 0.265% |
| 5 | 0.864% | 1.517% |
| 10 | 2.15% | 3.733% |
| 15 | 3.897% | 7.014% |
| 20 | 7.024% | 12.433% |
Relationships between endpoints
↥Index endpoint: M13_BONEDISNAS – Other specified/unspecified disorders of bone/cartilage
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data