Rhinophyma

L12_RHINOPHYMA

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L71.1 Hospital discharge: ICD-9 — 6953D Hospital discharge: ICD-8 — 69530 Cause of death: ICD-10 — L71.1 Cause of death: ICD-9 — 6953D Cause of death: ICD-8 — 69530 2 out of 7 registries used, show all original rules.	253
4. Check minimum number of events None	253
5. Include endpoints None	253
6. Filter based on genotype QC (FinnGen only)	225

Control definitions (FinnGen only)

Control exclude: L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L71
Name in latin: Rhinophyma

NAME	L12_RHINOPHYMA
CONTROL_EXCLUDE	L12_DISORDSKINAPPENDIX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L711
HD_ICD_9	6953D
HD_ICD_8	69530
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L711
COD_ICD_9	6953D
COD_ICD_8	69530
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Rhinophyma based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1418	326	1079
Only index persons	1182	258	924
Unadjusted period prevalence (%)
Whole population	0.03	0.01	0.03
Only index persons	0.03	0.01	0.04
Median age at first event (years)
Whole population	62.67	49.47	66.72
Only index persons	62.60	47.46	66.83

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	225	33	192
Unadjusted period prevalence (%)	0.08	0.01	0.09
Median age at first event (years)	65.53	47.42	68.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
231: Matched controls
2310

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L71.1

ICD-10 Finland

Rhinophyma

16384.0

291.8

215

D10BA01

ATC

isotretinoin; oral

159.8

233.2

118

D06BX01

ATC

metronidazole; topical

40.9

188.9

150

100

L71.9

ICD-10 Finland

Rosacea, unspecified

98.5

139.9

J01AA07

ATC

tetracycline; systemic

14.1

87.1

105

129

J01AA04

ATC

lymecycline; systemic

8.4

49.6

145

L71.8

ICD-10 Finland

Other rosacea

293.3

47.9

QAA25

NOMESCO Finland

Destruction of lesion of head or neck

10.6

24.9

L71

ICD-10 Finland

Rosacea

26.3

23.3

D10AX03

ATC

azelaic acid; topical

21.2

22.5

69530

ICD-8 Finland

Erythematous condition, Rosacea

+∞

17.9

QAE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in head or neck

3.7

12.9

149

E0000UV, ,

ATC

2.7

12.3

110

581

D10AF01

ATC

clindamycin; topical

11.4

12.1

L71.0

ICD-10 Finland

Perioral dermatitis

126.0

11.5

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

3.5

10.7

139

E000001, ,

ATC

3.0

10.6

222

DLW99

NOMESCO Finland

Other plastic operations on nose

+∞

10.5

QAA40

NOMESCO Finland

Laser therapy or photocoagulation of skin of head or neck

+∞

10.5

ZXC12

NOMESCO Finland

Pulse colorlaser

+∞

9.4

DHB00

NOMESCO Finland

Excision of lesion of external nose

14.8

8.8

ZXC10

NOMESCO Finland

Use of laser

8.4

8.5

M10.9

ICD-10 Finland

Gout, unspecified

3.1

7.9

130

QAA05

NOMESCO Finland

Incision for biopsy of skin of head or neck

8.1

7.5

I10

ICD-10 Finland

Essential (primary) hypertension

2.4

7.0

178

1359

205

Kela drug reimbursment

Chronic hypertension

2.1

7.0

530

L72.1

ICD-10 Finland

Trichilemmal cyst

4.3

6.8

R60.0

ICD-10 Finland

Localized oedema

2.6

6.5

177

XCW99

NOMESCO Finland

Other investigative procedure of eye

2.8

6.4

140

S29

ICPC

Skin symptom/complaint other

2.3

6.2

284

J01DB01

ATC

cefalexin; oral

2.5

6.2

193

1557

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3002256) Pathology report gross observation

254

2.24

5.48

1.7

1.3

—

(3009261) Glucose [Presence] in Urine by Test strip

140

1059

1.82

4.60

5.2

4.1

0.00

1.41

estimate

0.51

215

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

169

1357

1.91

4.56

3.9

3.5

14.94

15.00

pmol/l

0.10

157

1198

(3035350) Ketones [Presence] in Urine by Test strip

138

1054

1.77

4.25

5.2

4.1

0.00

estimate

-0.00

236

(3026493) Urate [Moles/volume] in Serum or Plasma

583

1.79

4.21

3.4

3.1

384.95

372.71

umol/l

0.49

498

(3009508) Creatinine [Moles/volume] in Urine

109

780

1.75

4.21

3.8

3.5

7.80

8.35

mmol/l

0.74

649

(3021601) Nitrite [Presence] in Urine by Test strip

135

1039

1.72

3.92

5.2

4.1

0.00

estimate

-0.00

231

(3012516) Albumin [Mass/volume] in Urine

106

771

1.69

3.74

3.8

3.6

93.40

64.40

mg/l

0.44

542

(3020682) Albumin/Creatinine [Ratio] in Urine

109

799

1.69

3.73

4.5

4.2

15.16

11.47

mg/mmol

0.29

541

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

4.70

3.47

1.1

1.5

—

nmol/l

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

125

965

1.64

3.40

5.4

5.8

34.54

34.62

g/l

0.06

118

908

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

183

1565

1.81

3.35

9.9

9.6

82.22

81.48

u/l

0.08

175

1493

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

208

1871

2.12

3.03

22.4

20.0

25.34

28.95

mg/l

0.73

183

1577

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

122

960

1.57

2.91

2.3

2.2

87.48

91.40

pmol/l

0.51

547

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

3.11

2.74

1.3

1.8

—

(3012544) pH of Venous blood

257

1.78

2.66

3.4

3.8

7.36

7.38

0.65

150

(3002582) Erythrocytes [#/volume] in Urine

756

1.54

2.62

4.4

3.5

17.15

141.11

e6/l

0.87

601

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

191

1693

1.74

2.61

5.2

4.6

1.98

2.04

mu/l

0.24

181

1524

(40768804) Tissue Pathology biopsy report

741

1.53

2.54

2.8

2.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

472

1.59

2.50

5.7

3.7

—

0.33

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

254

1.75

2.49

3.6

3.8

5.90

5.65

kpa

0.78

243

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

134

1101

1.52

2.47

7.3

8.3

1.21

1.20

mmol/l

0.57

112

961

(3015736) pH of Urine

106

833

1.50

2.40

4.8

3.8

6.18

6.15

0.10

501

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

103

805

1.50

2.39

2.8

2.3

70.79

75.38

nmol/l

0.85

699

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

2.46

2.34

1.2

55.60

98.85

u/ml

—

(3000991) Gas panel - Venous blood

211

1.78

2.34

5.3

10.0

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

203

1852

1.79

2.23

6.3

5.7

6.24

6.16

mmol/l

0.43

189

1684

(3018095) Leukocytes [#/volume] in Urine

103

816

1.47

2.19

5.2

4.1

32.39

90.20

e6/l

1.42

616

(3029937) Albumin [Presence] in Urine by Test strip

615

1.49

2.11

6.4

4.0

0.00

0.01

estimate

0.50

207

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

202

1848

1.74

2.09

7.4

5.5

4.16

4.32

mmol/l

1.54

194

1701

(44816559) Phosphatidylethanol [Mass/volume] in Blood

2.08

2.07

1.3

1.6

0.27

0.37

mg/l

—

(36304419) Bacteria [Presence] in Urine

609

1.48

2.05

4.0

3.3

—

0.00

estimate

—

(3030467) Casts [#/volume] in Urine by Automated count

656

1.47

2.03

4.2

3.3

0.48

0.45

e6/l

0.06

497

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

102

817

1.44

2.00

5.8

4.2

0.00

0.02

estimate

0.50

199

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

771

1.44

1.98

2.6

2.0

1.39

1.32

mmol/l

0.45

625

(3035715) Granulocytes [#/volume] in Blood

2.92

1.88

4.0

2.5

3.69

4.78

e9/l

—

(3034770) Mitochondria Ab [Titer] in Serum

2.28

1.88

1.1

1.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

199

1827

1.64

1.85

7.9

7.4

40.35

40.72

mmol/mol

0.25

186

1704

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

162

1.75

1.85

2.0

3.0

59.22

61.53

ml/min/173m2

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

200

1839

1.65

1.85

6.4

5.4

1.29

1.35

mmol/l

1.65

184

1675

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

4.23

1.83

1.4

1.1

—

(3045716) Anion gap in Serum or Plasma by calculation

2.82

1.81

2.3

11.75

10.55

mmol/l

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

113

937

1.40

1.77

2.2

2.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

204

1890

1.68

1.76

7.3

6.3

2.40

2.51

mmol/l

1.04

192

1729

(3002179) Metamyelocytes/Leukocytes in Blood

189

1.67

1.74

4.9

4.2

0.45

0.47

0.03

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

115

960

1.39

1.72

2.5

3.0

—

estimate

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

410

1.48

1.72

3.6

3.1

1.31

0.98

e6/l

0.27

245

(3000850) Epithelial cells [#/volume] in Urine

537

1.44

1.69

3.6

2.7

5.19

3.35

e6/l

0.63

486

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

103

846

1.39

1.69

4.9

3.5

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

165

1468

1.43

1.68

6.1

4.5

13.74

13.28

mm/h

0.12

157

1366

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

194

1782

1.55

1.67

6.2

4.6

1.40

1.28

mmol/l

1.54

183

1614

(3004588) Protein electrophoresis panel - Serum or Plasma

176

1.67

1.64

2.5

3.0

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

119

1006

1.38

1.62

8.2

7.5

1.20

mmol/l

0.09

112

929

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

2.55

1.61

1.4

3.0

30.50

33.34

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

2.38

1.61

1.1

1.5

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

691

1.39

1.58

2.9

4.1

2.33

mmol/l

0.04

621

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

3.38

1.53

1.6

1.1

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

2.55

1.46

1.4

1.7

—

(3018418) pH of Serum or Plasma

643

1.37

1.45

6.3

5.0

7.41

7.40

0.90

478

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

197

1830

1.52

1.45

23.9

18.9

71.91

75.60

ml/min/173m2

1.69

185

1710

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

141

1238

1.36

1.44

3.8

3.6

67.28

60.84

u/l

0.33

133

1155

(3011648) Oxygen content in Venous blood

2.77

1.44

1.0

2.2

9.32

11.16

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.30

1.42

1.0

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

129

1120

1.34

1.41

5.1

4.9

23.13

21.64

0.57

585

(3019309) Folate [Moles/volume] in Red Blood Cells

418

1.41

1.38

1.8

1.7

1254.36

1201.21

nmol/l

0.16

329

(3025159) Blasts/Leukocytes in Blood

193

1.57

1.38

4.9

4.7

0.09

0.18

0.23

(3010144) Erythrocytes [#/volume] in Synovial fluid

2.65

1.37

1.8

1.2

13672.83

54155.18

e6/l

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

202

1.56

1.36

1.5

—

(40761511) CBC panel - Blood by Automated count

204

1915

1.56

1.36

20.5

18.1

—

(3021589) Normoblasts [#/volume] in Blood

106

900

1.33

1.32

16.0

12.7

0.00

e9/l

0.30

735

(3001122) Ferritin [Mass/volume] in Serum or Plasma

103

872

1.33

1.31

3.0

2.8

140.31

171.88

ug/l

1.05

804

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

816

1.33

1.28

3.7

3.4

1362.18

1607.63

ng/l

0.38

705

(40761535) Cells panel - Urine sediment

172

1.58

1.27

5.4

3.4

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

140

1.63

1.25

1.6

1.5

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

124

1.67

1.25

4.6

3.5

25.36

24.47

mmol/l

0.42

118

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

704

1.33

1.25

3.5

2.8

56.74

62.67

u/l

0.34

666

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.77

1.24

1.4

1.3

—

(3013512) EKG study

819

1.32

1.24

4.4

4.1

—

(3035933) Granulocytes/Leukocytes in Blood

2.20

1.22

4.1

2.8

53.00

59.61

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

2.67

1.22

1.2

1.1

—

(3003338) MCHC [Entitic Mass/volume] in Red Blood Cells

163

1482

1.34

1.21

27.7

25.9

332.18

333.15

g/l

0.65

163

1476

(3019977) pH of Arterial blood

329

1.42

1.21

5.1

8.2

7.42

7.41

0.08

197

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

154

1389

1.33

1.21

6.2

5.9

2.82

2.81

ug/l

0.01

135

1239

(3028308) Erythrocytes [#/volume] in Pleural fluid

0.00

1.16

0.0

1.5

—

23788.75

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.80

1.15

1.1

1.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

386

1.38

1.15

3.7

3.3

1.47

1.17

e6/l

0.19

224

(3037522) Nuclear Ab [Titer] in Serum

228

1.47

1.13

1.4

1.3

360.00

477.60

titre

—

(1616796) Gas panel - Central venous blood

2.00

1.13

4.6

3.4

—

(3020779) Urea [Moles/volume] in Serum or Plasma

237

1.46

1.13

6.6

7.4

11.32

10.89

mmol/l

0.12

225

(3021440) Promyelocytes/Leukocytes in Blood

186

1.51

1.12

5.8

4.6

0.00

0.09

—

(3003396) Base excess in Arterial blood by calculation

325

1.40

1.12

5.2

8.3

1.51

0.90

mmol/l

0.53

266

(3023520) Reticulocytes [#/volume] in Blood

247

1.44

1.10

1.7

2.9

73.06

66.77

e9/l

0.47

191

(40761536) Microorganisms panel - Urine sediment

162

1.54

1.09

5.6

3.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

214

1.46

1.06

1.7

1.6

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

673

1.29

1.02

3.2

4.0

31.61

37.66

u/l

0.97

636

(3017181) Myelocytes/Leukocytes in Blood

199

1.46

1.01

5.6

4.5

0.35

0.92

—

(3027456) Digoxin [Moles/volume] in Serum or Plasma

1.83

0.98

3.7

3.0

0.87

0.88

nmol/l

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

1.71

0.93

2.8

4.4

2.10

3.20

ratio

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.71

0.93

3.2

1.5

—

(40758558) Short blood count panel - Blood

595

1.28

0.93

6.0

6.5

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

401

1.32

0.90

2.0

1.9

32.10

29.35

0.95

389

(42870588) Differential panel, method unspecified - Blood

716

1.25

0.85

6.2

6.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

251

1.37

0.84

7.5

8.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

583

1.26

0.84

4.1

3.8

0.00

0.14

estimate

0.52

187

(3017143) Hepatitis C virus Ab [Presence] in Serum

190

1.42

0.83

2.3

1.6

—

(3021960) Folate [Moles/volume] in Serum or Plasma

680

1.25

0.82

1.8

1.7

16.86

19.59

nmol/l

1.07

556

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

596

1.25

0.80

2.4

2.2

2.85

mg/l

0.00

524

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.79

0.0

1.5

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

210

1.38

0.78

3.3

2.8

0.40

0.31

e6/l

0.13

205

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

1.78

0.77

1.3

1.1

—

(21494890) Protein electrophoresis panel - 24 hour Urine

1.78

0.77

1.2

2.2

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

1.67

0.76

1.9

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

265

1.33

0.75

1.3

1.8

—

(3023368) Bacteria identified in Blood by Culture

734

1.23

0.75

3.6

4.9

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

470

1.25

0.72

1.8

394.37

415.27

pmol/l

0.31

399

(3021879) Hepatitis B virus core Ab [Presence] in Serum

118

1.48

0.71

2.4

1.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

105

943

1.21

0.71

5.6

4.4

495.48

44.20

ng/l

0.47

760

(3026008) Bacteria identified in Urine by Culture

594

1.23

0.71

3.1

3.4

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

179

1.38

0.70

2.5

2.6

30.00

36.62

u/l

0.66

152

(3052851) Hemolysis interference index of Serum or Plasma

1.67

0.69

2.8

3.3

0.00

2.53

index

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

1.87

0.69

5.0

4.0

1.66

8.80

nmol/l

—

(3025941) Bacteria identified in Stool by Culture

1.52

0.68

1.2

1.3

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

455

1.24

0.67

4.3

4.4

200.48

391.69

ng/l

0.50

396

(3032080) INR in Blood by Coagulation assay

125

1147

1.20

0.66

19.2

17.6

1.29

1.33

inr

0.35

105

991

(3019150) Specific gravity of Urine by Refractometry

485

1.23

0.65

6.7

4.2

1.02

kg/l

0.21

337

(3020891) Body temperature

122

1.42

0.62

8.2

4.6

36.98

36.87

°c

1.15

122

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.60

0.0

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

519

1.21

0.59

2.5

2.6

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.58

0.0

1.1

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.58

0.0

3.2

—

11.35

—

(3044640) Blood type and Crossmatch panel - Blood

694

1.19

0.57

2.4

2.6

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

1.64

0.56

1.0

2.0

—

4.62

—

(40760892) CBC W Ordered Manual Differential panel - Blood

427

1.22

0.56

7.2

5.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

143

1.36

0.54

3.8

2.7

0.65

0.68

0.13

143

(40768800) Prostate Pathology biopsy report

0.62

0.53

1.7

1.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

430

1.21

0.52

1.8

2.1

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

1.51

0.52

1.8

1.2

1.17

4.79

e6/l

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

440

1.20

0.52

1.6

1.7

1.20

1.79

mg/l

0.53

348

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

145

1.34

0.50

3.8

2.7

1.26

1.25

0.02

145

(40768443) Skin Pathology biopsy report

1.45

0.50

1.2

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

818

1.16

0.50

3.6

3.3

0.95

0.84

ug/l

0.49

563

(3042936) Bacteria identified in Isolate by Culture

352

0.80

0.49

1.7

2.0

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

110

0.63

0.49

2.3

4.1

18.91

11549.79

u/ml

—

(40768797) Stomach Pathology biopsy report

256

1.24

0.47

1.5

1.3

—

(3026782) Osmolality of Urine

463

1.19

0.47

3.4

3.3

587.00

580.86

mosm/kgh2o

0.07

407

(3013650) Neutrophils [#/volume] in Blood by Automated count

124

1160

1.15

0.46

9.8

10.8

4.44

4.27

e9/l

0.37

108

1012

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

267

1.23

0.45

1.4

1.3

1.14

15.36

u/ml

1.82

102

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

295

1.22

0.45

1.4

1.3

32.87

39.32

iu/ml

—

(3003694) ABO and Rh group [Type] in Blood

525

1.17

0.43

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.42

0.42

1.4

1.2

—

(1002224) Polysomnography panel

1.42

0.42

1.0

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

316

1.20

0.42

2.0

2.1

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.3

—

(3017704) Immunofixation for Urine

0.00

0.41

0.0

2.1

—

(3037121) Protein [Mass/volume] in Urine

1.38

0.41

4.8

3.3

229.29

301.36

mg/l

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.41

0.0

3.2

—

0.76

—

(3000492) Spirometry study

178

1.26

0.40

1.3

1.5

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.40

0.0

1.2

—

(3051014) Leukocytes [#/area] in Urine sediment by Automated count

0.00

0.39

0.0

1.6

—

2.00

—

(3019060) Gas panel - Arterial blood

179

1.25

0.39

5.0

4.9

—

(3021788) Differential panel - Synovial fluid

1.40

0.38

2.0

1.3

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

1.36

0.37

8.4

3.2

10.04

11.83

pmol/l

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

1.48

0.36

2.2

1.4

1139.33

3148.77

e6/l

—

(3023419) Bacteria identified in Sputum by Culture

1.44

0.36

1.2

2.9

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

1.41

0.35

1.7

1.6

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

1.34

0.34

1.7

1.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.32

0.30

1.2

—

(4094501) Cardiovascular stress test using bicycle ergometer

1.26

0.29

1.3

1.1

—

(3048689) Calprotectin [Mass/mass] in Stool

186

1.20

0.29

3.6

2.3

129.71

185.53

ug/g

0.57

156

(1761868) Lipid panel - Serum or Plasma

648

1.12

0.29

4.3

3.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

300

1.16

0.28

2.1

2.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

253

1.17

0.28

2.4

1.7

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.26

0.28

1.4

1.8

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.26

0.28

1.1

1.6

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

105

1.25

0.25

2.2

2.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.19

0.25

1.2

1.3

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

180

1.18

0.24

1.3

1.4

—

(3006315) Basophils [#/volume] in Blood

111

1062

1.09

0.23

8.3

6.1

0.04

e9/l

0.59

905

(3019198) Lymphocytes [#/volume] in Blood

112

1072

1.09

0.23

8.4

6.2

2.60

1.78

e9/l

0.48

100

945

(3009343) pH of Capillary blood

192

1.16

0.21

2.6

3.6

7.40

7.42

0.41

161

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

103

0.77

0.21

2.6

3.3

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3024471) HLA-A [Type]

0.00

0.21

0.0

1.0

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.21

0.0

1.7

—

41.60

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.8

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.8

—

(3024932) HLA-DR beta [Type]

0.00

0.21

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3036185) Alkaline phosphatase.liver 2 [Enzymatic activity/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

64.00

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.3

—

1063.10

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

1.8

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.21

0.0

1.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.21

0.0

2.7

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.21

0.0

2.1

—

12.09

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.21

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3001604) Monocytes [#/volume] in Blood

110

1056

1.08

0.20

8.4

6.1

0.64

0.63

e9/l

0.12

898

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.20

0.0

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

368

1.11

0.19

1.3

1.2

1.05

1.93

u/ml

—

104

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

278

0.89

0.18

4.7

5.3

33.37

31.12

0.41

177

(3007164) IgA [Mass/volume] in Serum or Plasma

369

1.10

0.18

1.4

3.05

2.76

g/l

0.45

225

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.22

0.18

1.6

1.8

—

(3019225) pH of Specimen

215

1.13

0.17

4.6

4.4

7.34

7.35

0.06

158

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.18

0.17

1.6

1.3

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

1.19

0.15

1.5

2.4

0.61

0.33

iu/ml

—

(3013115) Eosinophils [#/volume] in Blood

112

1087

1.06

0.14

8.3

6.3

0.20

e9/l

0.00

945

(36660697) Celiac disease serology panel - Serum

128

0.85

0.14

1.1

1.2

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

100

0.79

0.14

1.9

1.4

—

67.25

—

(3000494) Fungus identified in Specimen by Culture

262

0.91

0.13

1.4

1.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.15

0.10

1.6

2.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

252

1.08

0.10

4.0

3.5

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.11

0.10

1.8

1.3

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.04

0.09

1.4

1.2

—

(4035726) Immunohistochemistry procedure

185

0.91

0.08

1.5

—

(3037756) Immunofixation for Serum or Plasma

0.80

0.08

1.4

1.7

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.76

0.08

2.2

1.6

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.83

0.07

1.0

1.8

216.17

204.94

pmol/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.08

0.07

3.4

1.3

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

168

1.08

0.06

2.6

3.7

0.34

1.83

mmol/l

0.92

128

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

149

1.08

0.05

1.6

1.8

—

(21494755) Public health laboratory ask at order entry panel

101

1.09

0.04

2.0

1.5

—

(3005322) IgE [Units/volume] in Serum or Plasma

109

0.91

0.04

1.1

1.2

69.37

408.85

u/ml

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

178

0.95

0.02

1.5

1.7

—

(3022145) Colonoscopy Study observation

238

0.96

0.02

1.3

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

278

0.97

0.02

2.0

2.4

12.55

13.35

nmol/l

0.19

248

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

253

1.03

0.01

3.1

5.1

3.07

66.83

ug/l

1.25

211

(3000330) Specific gravity of Urine by Test strip

118

1.02

0.00

2.4

4.3

1.02

ratio

0.17

111

(3049717) Cytology report of Urine Cyto stain

121

0.99

0.00

2.9

2.7

—

(3022313) Gas panel - Capillary blood

141

0.99

0.00

2.6

3.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

195

0.97

0.00

1.5

1.3

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.2

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

0.0

1.3

—

11.78

—

(3020951) Lymphocytes/Leukocytes in Cerebral spinal fluid

0.00

0.0

1.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.91

0.00

1.4

1.6

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.1

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.0

—

8.77

—

(42529528) Centromere protein B Ab [Units/volume] in Serum by Line blot

0.00

0.0

1.3

—

(3038071) Oxygen [Partial pressure] in Mixed venous blood

0.00

0.0

9.1

—

4.63

—

(4015189) Microbial culture of sputum

0.00

0.0

1.9

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.1

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.1

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

2.4

—

1.48

—

(21494814) CD8 cells/Lymphocytes in Specimen

0.00

0.0

1.4

—

37.86

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.02

-0.00

1.4

1.2

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

2.3

—

(3048518) aPTT.lupus sensitive actual/normal (normalized LA screen)

0.00

-0.00

0.0

1.2

—

1.11

—

(3015956) Eosinophils/Leukocytes in Blood by Manual count

0.00

-0.00

0.0

2.7

—

1.67

—

(4034850) Laboratory test

0.88

-0.00

21.5

14.3

—

(4024509) Urine culture

0.98

-0.00

2.3

2.0

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

-0.00

0.0

2.3

—

13.75

—

(4133840) Spirometry

0.00

-0.00

0.0

1.3

—

(42868415) European tick borne encephalitis virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.2

—

(3042847) Granulocytes/Leukocytes in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.97

-0.00

3.8

1.5

—

(42868417) European tick borne encephalitis virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3015479) Mycobacterium sp identified in Blood by Organism specific culture

0.00

-0.00

0.0

1.5

—

(3034426) Prothrombin time (PT)

0.00

-0.00

0.0

1.0

—

25.33

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.02

-0.00

1.4

1.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.00

-0.00

1.4

1.3

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.96

-0.00

1.7

1.5

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.3

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3034037) Hematocrit [Volume Fraction] of Mixed venous blood by calculation

0.00

-0.00

0.0

9.7

—

11.03

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.2

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.4

—

(3017962) TCRG gene rearrangements [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

61.28

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

15.6

—

1259.00

—

(42868499) Enterovirus IgG Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.0

—

(3014891) Appearance of Pleural fluid

0.00

-0.00

0.0

1.6

—

(40761539) Cells [Type] in Urine sediment by Light microscopy

0.00

-0.00

0.0

1.2

—

(3020650) Glucose [Presence] in Urine

0.00

-0.00

0.0

1.2

—

0.00

—

(40757373) Influenza virus identified in Isolate

0.00

-0.00

0.0

1.2

—

(3005033) Fetal Nuchal fold Thickness US

0.00

-0.00

0.0

1.2

—

1.23

—

(3032057) Clostridioides difficile [Presence] in Stool

0.00

-0.00

0.0

1.6

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.2

—

(3018851) Theophylline [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

41.00

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

8.8

—

857.60

—

(3023365) Varicella zoster virus Ab [Titer] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_RHINOPHYMA and mortality.

Females

No data

Males

Parameter	HR [95% CI]	p-value
L12_RHINOPHYMA	1.076 [0.9, 1.29]	0.435
Birth year	0.991 [0.98, 1.0]	0.056

During the follow-up period (1.1.1998 — 31.12.2019), 223 out of 774 males with L12_RHINOPHYMA died.

Mortality risk

Mortality risk for people of age

years, who have L12_RHINOPHYMA.

N-year risk	Females	Males
1	No data	0.243%
5	No data	1.406%
10	No data	3.532%
15	No data	6.807%
20	No data	11.741%

Relationships between endpoints

↥

Index endpoint: L12_RHINOPHYMA – Rhinophyma

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Rhinophyma

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints