Acne varioliformis

L12_ACNE_VARIOLIFORMIS

acne: An inflammatory process of the sebaceous glands which is characterized by comedones, nodules, papules and/or pustules on the skin.

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L70.2 Hospital discharge: ICD-9 — 7060A Hospital discharge: ICD-8 — 70601 Cause of death: ICD-10 — L70.2 Cause of death: ICD-9 — 7060A Cause of death: ICD-8 — 70601 2 out of 7 registries used, show all original rules.	104
4. Check minimum number of events None	104
5. Include endpoints None	104
6. Filter based on genotype QC (FinnGen only)	93

Control definitions (FinnGen only)

Control exclude: L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L70
Name in latin: Acne varioliformis

NAME	L12_ACNE_VARIOLIFORMIS
CONTROL_EXCLUDE	L12_DISORDSKINAPPENDIX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L702
HD_ICD_9	7060A
HD_ICD_8	70601
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L702
COD_ICD_9	7060A
COD_ICD_8	70601
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Acne varioliformis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	575	296	276
Only index persons	520	275	245
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	54.38	52.45	56.29
Only index persons	51.46	50.11	52.97

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	93	53	40
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	51.24	47.18	56.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
95: Matched controls
950

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L70.2

ICD-10 Finland

Acne varioliformis

9951.3

124.4

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

4.7

10.6

A10AE04

ATC

insulin glargine; parenteral

5.3

9.5

L73.2

ICD-10 Finland

Hidradenitis suppurativa

41.0

9.2

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

8.1

9.0

TPH07

NOMESCO Finland

Cathetrisation of artery

5.1

8.4

F32.9

ICD-10 Finland

Depressive episode, unspecified

4.4

8.4

PD4AC

NOMESCO Finland

Arterigography of lower extremity with X-ray

36.8

8.3

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

4.6

8.2

N05BA04

ATC

oxazepam; oral

3.6

8.2

148

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

12.4

8.1

ZXE00

NOMESCO Finland

One hour or less

3.3

7.6

247

S97

ICPC

Chronic ulcer skin

7.4

PG1DE

NOMESCO Finland

Other extensive ultrasound examination of artery

11.4

7.3

SPAT1148

SPAT

Treatment of chronic ulcer or burn

4.2

7.1

N02AX02

ATC

tramadol; systemic, rectal

3.1

7.0

281

PD4CG

NOMESCO Finland

Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet

43.3

6.9

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

9.8

6.8

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

7.5

6.7

Z2221

NOMESCO Finland

Medical doctor

3.1

6.4

168

N06AX12

ATC

bupropion; oral

4.5

6.3

N05AH04

ATC

quetiapine; oral

3.4

6.3

110

L70.0

ICD-10 Finland

Acne vulgaris

16.4

6.0

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

4.36

9.51

3.8

1.9

—

(42870588) Differential panel, method unspecified - Blood

265

3.00

6.47

8.1

5.0

—

(3019309) Folate [Moles/volume] in Red Blood Cells

116

3.32

6.32

1.8

1.9

1236.05

1299.34

nmol/l

0.11

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.07

6.10

2.0

1.3

—

(3002256) Pathology report gross observation

103

3.27

5.77

1.5

1.2

—

(3042936) Bacteria identified in Isolate by Culture

110

3.19

5.70

4.1

2.2

—

(3013115) Eosinophils [#/volume] in Blood

436

2.97

5.52

15.2

5.6

0.18

0.19

e9/l

0.08

388

(40758558) Short blood count panel - Blood

251

2.73

5.43

13.0

6.1

—

(3021589) Normoblasts [#/volume] in Blood

385

2.76

5.25

19.0

11.0

0.00

e9/l

0.50

313

(3023368) Bacteria identified in Blood by Culture

208

2.71

5.19

9.0

4.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

486

2.99

5.13

21.4

9.1

4.84

4.21

e9/l

0.90

428

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.28

5.03

8.5

3.8

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

3.21

5.03

2.0

3.2

22.81

29.06

u/l

1.03

(3006315) Basophils [#/volume] in Blood

420

2.73

4.97

9.1

5.5

0.04

e9/l

0.18

364

(3007164) IgA [Mass/volume] in Serum or Plasma

197

2.66

4.94

1.5

1.3

2.98

2.25

g/l

0.85

111

(3001604) Monocytes [#/volume] in Blood

422

2.71

4.89

8.7

5.4

0.66

0.57

e9/l

1.28

368

(3011288) Drugs identified in Urine by Screen method Nominal

4.89

5.8

2.6

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

344

2.53

4.64

7.4

4.2

33.64

35.84

g/l

1.29

331

(3019198) Lymphocytes [#/volume] in Blood

440

2.64

4.57

8.8

5.4

1.90

1.95

e9/l

0.11

400

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

349

2.47

4.43

14.1

6.6

1.19

1.21

mmol/l

0.89

328

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

350

2.46

4.39

2.4

2.0

86.92

96.58

pmol/l

0.71

180

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

5.51

4.15

3.0

1.6

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

6.97

4.09

1.8

1.6

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

6.97

4.09

1.8

1.6

—

(3028707) Methadone [Presence] in Urine by Screen method

4.75

3.98

7.5

1.3

—

(3019977) pH of Arterial blood

2.71

3.56

16.9

9.3

7.40

7.42

—

(3012441) Differential panel - Pleural fluid

10.55

3.54

1.5

2.0

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

4.47

3.52

2.3

2.0

—

(3009508) Creatinine [Moles/volume] in Urine

266

2.22

3.51

6.2

3.1

6.83

8.19

mmol/l

1.61

227

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

383

2.22

3.49

14.1

7.0

1.18

1.21

mmol/l

1.79

334

(3026008) Bacteria identified in Urine by Culture

242

2.22

3.46

3.3

2.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

133

2.44

3.45

2.1

1.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

187

2.27

3.39

4.4

2.3

—

(3018418) pH of Serum or Plasma

237

2.19

3.32

9.2

3.6

7.40

0.05

167

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

6.76

3.24

4.0

1.0

—

(3018095) Leukocytes [#/volume] in Urine

328

2.11

3.16

4.9

3.4

182.71

89.10

e6/l

0.38

230

(40768806) Pleura Pathology biopsy report

7.91

3.10

1.7

2.0

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

111

2.41

3.05

1.9

2.8

4.75

7.96

umol/l

0.55

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

227

2.12

3.04

1.6

1.2

1.90

1.67

u/ml

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

278

2.09

3.04

4.8

2.9

2.35

mmol/l

0.03

254

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

10.45

3.01

34.6

12.0

747.80

876.60

nmol/l

—

(3044640) Blood type and Crossmatch panel - Blood

271

2.07

2.98

4.4

2.2

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

4.40

2.96

2.7

1.5

1.02

1.16

g/l

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

106

2.40

2.92

18.9

8.3

102.09

104.47

mmol/l

1.07

106

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

100

2.41

2.85

2.1

1.8

—

(3016879) Cocaine [Presence] in Urine

2.87

2.85

7.9

1.9

—

(3000764) Benzodiazepines [Presence] in Urine

2.87

2.85

7.9

1.9

—

(3000991) Gas panel - Venous blood

2.62

2.85

23.4

9.3

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

329

2.01

2.81

1.9

1.8

1.53

1.40

mmol/l

0.40

276

(3001122) Ferritin [Mass/volume] in Serum or Plasma

405

2.02

2.77

4.7

2.9

131.60

91.69

ug/l

0.72

387

(36660697) Celiac disease serology panel - Serum

2.58

2.77

1.4

1.1

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.92

2.75

7.4

1.9

—

(3027944) Amphetamines [Presence] in Urine

2.76

2.67

8.1

1.9

—

(3028300) Cannabinoids [Presence] in Urine

2.76

2.67

8.1

1.9

—

(3027008) Opiates [Presence] in Urine

2.76

2.67

7.9

1.9

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

4.94

2.65

1.6

1.7

—

(3030467) Casts [#/volume] in Urine by Automated count

246

1.99

2.63

4.0

2.7

2.37

0.42

e6/l

0.60

182

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

104

2.31

2.61

2.1

1.8

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

5.74

2.58

1.8

1.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.37

2.52

1.7

1.2

—

(3024928) Oxygen saturation in Venous blood

3.87

2.42

5.9

1.8

65.01

61.52

—

(3032080) INR in Blood by Coagulation assay

362

1.88

2.36

35.4

12.2

1.36

1.19

inr

1.19

302

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

124

2.13

2.33

4.0

2.9

3.50

2.24

e6/l

0.24

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

3.70

2.33

1.1

1.3

—

2.16

—

(3037522) Nuclear Ab [Titer] in Serum

117

2.15

2.30

1.5

1.4

617.14

427.20

titre

—

(3019230) Fractional oxyhemoglobin in Venous blood

4.11

2.30

6.0

1.7

58.57

59.54

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.98

2.21

2.1

1.5

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

601

2.05

2.20

5.5

3.8

18.02

11.13

mm/h

1.76

561

(3013826) Glucose [Moles/volume] in Serum or Plasma

475

1.88

2.20

12.0

5.1

8.21

6.56

mmol/l

2.99

447

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

3.89

2.19

2.7

1.4

0.00

g/l

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

192

1.91

2.14

1.8

1.7

1.14

1.28

mg/l

0.12

160

(3031040) Bacteria [#/volume] in Urine by Automated count

531

1.89

2.08

5.7

4.2

—

17.44

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

203

1.87

2.05

2.6

2.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.63

2.01

1.6

1.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

155

1.93

2.00

3.8

3.1

465.47

381.56

ng/l

0.08

109

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

3.14

1.98

1.1

1.4

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.93

1.97

1.2

1.4

—

(3048689) Calprotectin [Mass/mass] in Stool

117

2.02

1.94

2.1

1.9

180.00

116.02

ug/g

0.33

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

624

1.96

1.91

5.7

4.1

14.77

14.73

pmol/l

0.05

570

(3000494) Fungus identified in Specimen by Culture

103

2.06

1.88

1.8

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.17

1.88

2.5

1.8

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

135

1.93

1.84

3.5

2.6

1.36

1.02

e6/l

0.22

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

3.20

1.84

1.3

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

309

1.72

1.77

4.5

2.9

—

(3012516) Albumin [Mass/volume] in Urine

238

1.75

4.3

3.2

82.67

63.60

mg/l

0.16

166

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.41

1.71

1.4

1.1

—

(3035715) Granulocytes [#/volume] in Blood

3.30

1.69

2.7

3.3

5.76

4.32

e9/l

—

(3020682) Albumin/Creatinine [Ratio] in Urine

241

1.72

1.66

5.7

4.1

15.25

9.94

mg/mmol

0.22

161

(3000492) Spirometry study

2.03

1.62

1.6

1.5

—

(3034770) Mitochondria Ab [Titer] in Serum

2.55

1.58

1.3

1.4

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.98

1.53

1.5

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

127

1.84

1.53

2.3

1.5

—

(40768804) Tissue Pathology biopsy report

334

1.59

1.39

2.6

2.1

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.21

1.34

1.4

1.5

—

(40761536) Microorganisms panel - Urine sediment

1.91

1.32

6.2

3.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.93

1.29

1.5

1.4

—

(3023520) Reticulocytes [#/volume] in Blood

2.00

1.24

1.5

2.6

79.58

67.43

e9/l

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

813

2.12

1.22

36.9

14.9

26.97

23.30

mg/l

0.57

658

(3035933) Granulocytes/Leukocytes in Blood

2.39

1.20

3.0

2.7

66.83

58.61

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

391

1.52

1.19

4.8

2.6

—

estimate

—

(40768797) Stomach Pathology biopsy report

104

1.77

1.19

1.5

1.2

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

163

1.63

1.17

1.6

1.3

86.60

33.40

iu/ml

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.58

1.16

1.4

1.3

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

693

1.70

1.16

51.7

18.0

14.41

13.49

4.53

685

(21494755) Public health laboratory ask at order entry panel

108

0.43

1.09

1.2

1.5

—

(1616796) Gas panel - Central venous blood

2.34

1.04

16.2

3.3

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.99

0.0

1.2

—

1.59

—

(4035726) Immunohistochemistry procedure

1.82

0.98

1.2

1.3

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.84

0.98

11.3

2.8

24.44

24.67

mmol/l

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.84

0.98

1.6

2.8

303.89

207.01

ng/l

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.84

0.98

2.6

—

(3015736) pH of Urine

374

1.45

0.97

3.5

2.9

6.00

6.16

0.38

216

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.22

0.93

1.5

1.1

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.94

0.90

5.6

2.2

0.59

0.66

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.94

0.90

5.8

2.2

1.06

1.67

—

(1761868) Lipid panel - Serum or Plasma

340

0.68

0.90

4.1

2.9

—

(3023511) Choriogonadotropin [Units/volume] in Urine

2.07

0.88

1.5

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

230

1.44

0.84

3.1

5797.09

1302.10

ng/l

0.89

197

(4034850) Laboratory test

0.00

0.78

0.0

7.5

—

(40768443) Skin Pathology biopsy report

1.81

0.77

1.3

1.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.24

0.77

1.6

1.1

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

144

1.49

0.76

1.5

1.3

1.09

5.14

u/ml

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.66

0.76

2.3

2.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

2.14

0.75

1.4

1.7

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

2.05

0.74

1.4

1.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

174

1.42

0.68

2.2

1.7

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

800

1.59

0.64

6.4

5.3

2.38

2.70

mmol/l

2.98

757

(3025941) Bacteria identified in Stool by Culture

1.62

0.62

1.5

1.1

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.53

0.52

1.2

1.3

—

(3014051) Protein [Presence] in Urine by Test strip

252

0.74

0.52

2.7

2.4

—

0.00

—

(40761511) CBC panel - Blood by Automated count

843

1.60

0.52

27.3

12.9

—

(3041096) Erythrocytes [Presence] in Urine by Automated

273

0.75

0.52

4.8

2.8

0.00

estimate

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

292

1.26

0.43

5.6

3.9

24.64

36.08

ng/l

0.53

193

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

737

1.33

0.42

9.0

5.9

45.37

39.14

mmol/mol

2.38

697

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.41

0.0

1.1

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.41

0.0

3.5

—

28.60

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.41

0.0

3.3

—

1.69

—

(3008898) HLA-B27 [Presence]

1.50

0.41

1.2

1.1

—

(3022145) Colonoscopy Study observation

1.38

0.40

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.40

0.38

9.1

6.7

—

(3012544) pH of Venous blood

1.39

0.34

9.0

3.0

7.39

7.38

—

(3002032) Base excess in Venous blood by calculation

1.39

0.34

10.0

2.9

1.12

1.82

mmol/l

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.35

0.34

3.0

2.1

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

602

1.19

0.29

5.1

3.1

113.70

42.40

u/l

0.94

581

(40760892) CBC W Ordered Manual Differential panel - Blood

208

1.21

0.27

7.5

4.4

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

793

1.25

0.25

5.8

4.7

4.23

4.60

mmol/l

2.63

754

(40768441) Liver Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.3

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.6

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

5.6

—

152.60

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.9

—

67.70

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

110

0.80

0.21

1.6

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.21

0.0

3.8

—

6.66

—

(3019060) Gas panel - Arterial blood

1.24

0.20

4.0

4.8

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.20

0.0

1.4

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

359

0.88

0.20

4.5

3.2

0.00

0.01

estimate

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.19

0.20

1.0

1.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

138

1.19

0.19

3.1

2.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

194

0.85

0.19

3.1

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

148

1.18

0.18

1.3

1.6

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.25

0.18

2.7

5.5

3.12

64.38

ug/l

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.21

0.17

1.1

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

266

1.13

0.16

5.2

3.4

0.00

0.01

estimate

0.50

103

(3019150) Specific gravity of Urine by Refractometry

208

1.14

0.16

3.8

3.1

1.02

kg/l

0.11

133

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

790

1.17

0.15

5.6

4.6

1.26

1.45

mmol/l

3.67

743

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.81

0.15

7.3

5.1

26.00

33.68

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.12

0.10

1.4

1.2

—

18.58

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.07

0.09

1.0

1.3

—

(3019225) pH of Specimen

1.04

0.08

2.3

5.2

7.36

7.34

—

(40761535) Cells panel - Urine sediment

0.78

0.08

5.4

3.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

147

1.11

0.08

3.6

2.6

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

760

1.07

0.04

4.8

3.9

1.43

1.28

mmol/l

0.89

712

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

774

1.04

0.00

5.6

4.6

6.95

5.87

mmol/l

1.98

717

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

574

1.03

0.00

3.9

3.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

118

1.02

0.00

1.6

1.9

—

(3035350) Ketones [Presence] in Urine by Test strip

471

1.00

0.00

4.4

3.3

0.00

estimate

-0.00

113

(3009261) Glucose [Presence] in Urine by Test strip

473

0.99

0.00

4.4

3.3

0.00

estimate

-0.00

103

(3021601) Nitrite [Presence] in Urine by Test strip

465

1.02

0.00

4.4

3.3

0.00

estimate

-0.00

108

(3003694) ABO and Rh group [Type] in Blood

264

0.98

0.00

1.8

1.6

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.0

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

0.0

1.0

—

51.40

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3030558) Cytomegalovirus DNA [Units/volume] (viral load) in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.5

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.4

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.1

—

34.71

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.6

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

3.6

—

1.19

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

0.0

3.0

—

52.40

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(3027135) IgG subclass 1 [Mass/volume] in Serum

0.00

0.0

1.0

—

5.94

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.3

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.0

—

46.34

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3025271) CD3-CD16+CD56+ (Natural killer) cells [#/volume] in Blood

0.00

0.0

1.4

—

145.60

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.3

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

3.6

—

107.38

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

3.6

—

3.75

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

6.2

—

194.40

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

1.9

—

3.34

—

(3048518) aPTT.lupus sensitive actual/normal (normalized LA screen)

0.00

0.0

1.4

—

1.13

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

0.0

9.5

—

0.65

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.6

—

1.20

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.9

—

(3036185) Alkaline phosphatase.liver 2 [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.0

—

23.54

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.7

—

6.53

—

(3024139) IgG subclass 3 [Mass/volume] in Serum

0.00

0.0

1.0

—

0.49

—

(3035062) Alkaline phosphatase.liver 1 [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.0

—

65.22

—

(3028192) IgG subclass 2 [Mass/volume] in Serum

0.00

0.0

1.0

—

4.03

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.4

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

-0.00

0.0

2.0

—

13.30

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.3

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.5

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.0

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

107.67

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_ACNE_VARIOLIFORMIS and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_ACNE_VARIOLIFORMIS	3.159 [1.69, 5.9]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.158

During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 248 females with L12_ACNE_VARIOLIFORMIS died.

Males

Parameter	HR [95% CI]	p-value
L12_ACNE_VARIOLIFORMIS	2.79 [1.74, 4.47]	< 0.001
Birth year	0.985 [0.97, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 222 males with L12_ACNE_VARIOLIFORMIS died.

Mortality risk

Mortality risk for people of age

years, who have L12_ACNE_VARIOLIFORMIS.

N-year risk	Females	Males
1	0.295%	0.545%
5	1.815%	3.121%
10	4.642%	7.312%
15	8.799%	13.825%
20	14.855%	22.752%

Relationships between endpoints

↥

Index endpoint: L12_ACNE_VARIOLIFORMIS – Acne varioliformis

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Acne varioliformis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints