No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
236 |
4. Check minimum number of eventsNone |
236 |
5. Include endpointsNone |
236 |
6. Filter based on genotype QC (FinnGen only) |
208 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L70
- Name in latin
- Acne conglobata
Similar endpoints
↥List of similar endpoints to
Acne conglobata
based on the number of shared cases.
Similar with more cases:
- Acne
- Acne, including avohilmo
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2189 | 621 | 1555 |
| Only index persons | 2136 | 611 | 1525 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.02 | 0.04 |
| Only index persons | 0.05 | 0.02 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 21.34 | 25.74 | 19.47 |
| Only index persons | 21.13 | 25.47 | 19.39 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 208 | 96 | 112 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | 29.10 | 30.71 | 27.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 218
- Matched controls
- 2180
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L70.1
ICD-10 Finland
Acne conglobata
15244.4
296.7
213
*
D10BA01
ATC
isotretinoin; oral
36.9
170.4
150
123
L70.0
ICD-10 Finland
Acne vulgaris
45.7
150.8
99
39
J01AA07
ATC
tetracycline; systemic
12.8
82.9
123
200
J01AA04
ATC
lymecycline; systemic
8.6
54.3
97
185
L73.2
ICD-10 Finland
Hidradenitis suppurativa
91.2
35.1
38
5
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
9.2
23.2
30
37
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
8.9
23.2
31
40
L72.1
ICD-10 Finland
Trichilemmal cyst
9.1
22.3
29
36
L70
ICD-10 Finland
Acne
8.2
21.8
31
43
L70.9
ICD-10 Finland
Acne, unspecified
25.5
19.6
27
12
D10AX03
ATC
azelaic acid; topical
5.2
19.4
46
107
S10
ICPC
Boil/carbuncle
5.7
16.3
33
66
L02.0
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of face
17.0
14.8
23
15
L70.8
ICD-10 Finland
Other acne
57.2
14.0
16
*
J01FF01
ATC
clindamycin; systemic
3.1
12.9
75
319
G03HB01
ATC
cyproterone and estrogen; oral
4.0
12.8
41
119
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
11.0
12.3
23
23
S96
ICPC
Acne
11.5
12.1
22
21
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
6.0
11.9
22
40
E0000UV, ,
ATC
2.7
11.5
115
643
K59.1
ICD-10 Finland
Functional diarrhoea
5.9
10.6
20
37
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
5.0
10.3
23
50
380
Kela drug reimbursment
Adalimumab (hidradenitis suppurativa)
+∞
9.4
9
*
E0001A1, ,
ATC
8.9
9.3
19
23
XQ848
NOMESCO Finland
Dermatological photography
10.1
9.0
17
18
L02.9
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle, unspecified
5.0
8.5
19
41
P01AB01
ATC
metronidazole; oral, rectal
2.3
7.9
86
480
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
7.9
89
505
ZYC01
NOMESCO Finland
Remote contact by phone
3.8
7.8
25
72
H02AB06
ATC
prednisolone; systemic
2.2
7.6
100
602
N05BA04
ATC
oxazepam; oral
2.4
7.5
62
305
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.9
7.2
22
61
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.9
6.9
21
58
L02.8
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of other sites
9.1
6.7
13
15
J01DA01
ATC
[U] cefalexin
2.1
6.5
129
894
7061E
ICD-9 Finland
Diseases of sebaceous glands, Other acne[ACNE CONGLOBATA]
+∞
6.3
6
*
J04AB02
ATC
rifampicin; systemic
27.5
6.3
8
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
125
888
1.96
5.50
6.0
6.0
6.62
6.45
mmol/l
0.19
113
813
139
1025
1.98
5.47
15.0
9.6
4.20
4.02
e9/l
0.43
127
901
36
159
2.51
5.41
4.7
2.8
3681.75
6431.65
u/l
0.32
13
76
102
681
1.94
5.36
10.0
7.5
1.20
1.21
mmol/l
0.87
88
600
99
661
1.91
5.15
2.4
1.8
1.36
1.37
mmol/l
0.04
93
586
68
409
1.96
4.76
2.1
2.2
173.08
227.22
u/l
0.33
63
399
13
29
4.70
4.32
1.7
2.9
3.60
2.00
index
—
5
14
203
1810
2.77
3.79
19.4
11.4
21.79
21.99
mg/l
0.04
174
1419
84
574
1.75
3.79
2.2
1.8
91.83
96.00
pmol/l
0.49
59
295
19
75
2.68
3.57
2.5
3.1
7.13
6.71
iu/ml
—
6
16
149
1212
1.72
3.42
10.5
7.0
76.45
76.88
u/l
0.05
143
1146
191
1678
2.12
3.38
6.5
3.9
4.47
4.65
mmol/l
2.05
186
1594
84
592
1.68
3.30
4.7
3.1
27.66
30.42
u/l
0.66
79
564
117
902
1.64
3.22
3.4
2.9
93.26
82.55
ug/l
0.35
110
861
42
244
1.89
3.17
3.6
2.7
1.33
0.73
e6/l
0.85
17
118
40
230
1.91
3.11
3.7
2.9
3.53
3.33
e6/l
0.04
15
106
61
400
1.73
3.09
2.6
2.1
2.65
2.59
mg/l
0.09
55
349
8
16
5.15
3.08
1.0
1.3
—
—
—
0
0
53
340
1.74
2.89
2.9
1.8
1.38
1.39
%
0.05
47
310
17
71
2.51
2.88
1.4
2.0
39.00
39.47
u/l
0.06
17
63
13
48
2.82
2.77
2.4
2.3
—
—
—
0
0
149
1248
1.61
2.71
5.9
3.8
13.03
8.09
mm/h
2.92
143
1167
12
41
3.04
2.66
1.2
1.5
—
—
—
0
0
26
136
2.04
2.64
8.0
16.8
-0.39
0.74
mmol/l
0.41
21
112
30
167
1.92
2.57
8.2
10.2
104.33
104.55
mmol/l
0.07
30
167
21
104
2.13
2.46
2.8
3.4
5.01
5.08
kpa
0.16
21
99
68
489
1.57
2.34
3.0
2.9
17.02
29.27
ng/l
0.74
30
262
12
47
2.64
2.31
2.3
2.1
—
—
—
0
0
8
23
3.57
2.29
1.6
1.5
—
—
—
0
0
186
1674
1.76
2.28
5.2
3.8
1.34
1.40
mmol/l
1.11
178
1584
15
67
2.33
2.23
1.1
1.2
387.29
230.35
u/ml
—
7
37
5
9
5.65
2.22
1.2
1.0
244.32
288.11
mg/l
—
5
9
8
25
3.28
2.11
1.4
1.2
—
—
—
0
0
8
25
3.28
2.11
1.4
1.2
—
—
—
0
0
5
10
5.09
2.08
1.4
1.2
—
—
—
0
0
36
227
1.70
2.07
2.1
1.9
—
—
—
0
0
186
1692
1.68
1.96
5.7
4.2
2.67
2.80
mmol/l
1.42
178
1600
182
1647
1.64
1.96
16.8
9.9
99.03
97.12
ml/min/173m2
0.56
163
1445
5
11
4.62
1.95
1.8
1.3
1.96
1.71
mmol/l
—
5
11
9
34
2.72
1.89
1.1
1.3
—
—
—
0
0
6
17
3.60
1.85
1.3
1.8
—
—
—
0
0
73
559
1.46
1.82
1.5
1.4
0.63
2.65
u/ml
1.26
19
141
6
18
3.40
1.76
1.8
1.6
—
—
—
0
0
6
18
3.40
1.76
1.3
1.8
—
—
—
0
0
6
18
3.40
1.76
1.3
1.8
—
—
—
0
0
19
105
1.89
1.69
1.6
1.5
—
—
—
0
0
19
106
1.87
1.65
7.2
11.5
25.75
24.68
mmol/l
0.59
19
106
153
1356
1.43
1.61
4.8
3.9
14.67
14.57
pmol/l
0.20
148
1257
78
619
1.41
1.57
2.0
1.8
—
—
—
0
0
41
287
1.53
1.56
1.5
1.6
—
—
—
0
0
48
349
1.48
1.53
2.6
2.3
—
—
—
0
0
21
125
1.75
1.50
3.8
2.7
0.24
0.23
g/l
0.17
21
119
52
387
1.45
1.48
2.9
2.3
—
—
—
0
0
9
38
2.43
1.47
2.4
2.2
—
—
—
0
0
11
52
2.17
1.47
8.8
3.8
53.69
49.13
%
0.22
11
52
5
16
3.17
1.44
1.4
1.1
—
—
—
0
0
6
22
2.77
1.44
1.2
1.0
—
—
—
0
0
6
22
2.77
1.44
1.3
1.5
—
—
—
0
0
10
46
2.23
1.42
1.9
1.8
2.77
1.23
ug/l
—
10
40
5
17
2.98
1.36
1.4
1.8
—
—
—
0
0
56
431
1.40
1.32
4.5
2.8
0.33
0.30
e6/l
0.08
38
300
5
18
2.82
1.29
1.4
1.8
—
—
—
0
0
23
148
1.62
1.26
1.0
1.0
—
—
—
0
0
8
38
2.15
1.19
1.1
1.1
—
—
—
0
0
8
38
2.15
1.19
1.0
1.2
—
—
—
0
0
10
50
2.05
1.18
1.5
1.5
—
—
—
0
0
8
39
2.09
1.16
1.6
1.5
—
—
—
0
0
5
20
2.53
1.15
1.4
1.4
—
—
—
0
0
7
30
2.38
1.13
1.3
1.5
—
—
—
0
0
165
1518
1.36
1.13
6.7
4.3
37.82
37.27
mmol/mol
0.34
156
1438
14
81
1.78
1.12
1.4
1.4
—
—
—
0
0
19
121
1.62
1.10
1.4
1.4
272.74
307.58
mu/l
0.25
19
113
54
428
1.35
1.06
4.6
2.9
1.01
1.02
kg/l
2.03
39
267
64
521
1.32
1.06
2.4
2.4
—
—
—
0
0
28
198
1.48
1.04
4.7
2.9
4.57
8.41
umol/l
1.09
23
172
20
131
1.58
1.04
1.1
1.2
—
—
—
0
0
0
30
0.00
0.98
0.0
1.1
—
11.75
—
0
11
65
538
1.30
0.95
5.2
3.1
—
—
—
0
0
46
365
1.33
0.90
3.7
2.7
345.69
334.90
umol/l
0.31
39
338
8
45
1.81
0.85
2.0
1.6
—
—
—
0
0
47
378
1.31
0.84
5.6
4.0
9.51
15.83
mg/mmol
0.52
35
248
11
65
1.73
0.84
1.5
1.6
—
—
—
0
0
12
73
1.68
0.83
2.2
1.7
—
—
—
0
0
6
32
1.90
0.82
1.7
1.6
—
—
—
0
0
8
47
1.73
0.81
1.1
2.1
2.88
9.97
e6/l
—
8
37
8
47
1.73
0.81
1.4
2.2
1008.75
136.92
e6/l
—
8
38
101
896
1.24
0.81
4.2
3.3
0.00
0.00
estimate
-0.00
19
185
88
771
1.24
0.79
3.2
2.8
—
—
estimate
—
0
0
17
116
1.50
0.77
1.1
1.3
—
—
—
0
0
11
67
1.68
0.76
4.5
2.5
1.01
1.02
ratio
1.74
11
62
5
24
2.11
0.75
1.2
1.7
—
—
—
0
0
101
902
1.22
0.75
4.2
3.3
0.00
0.00
estimate
-0.00
19
179
7
38
1.87
0.74
2.9
1.7
—
—
—
0
0
5
25
2.02
0.73
1.0
1.2
222.10
193.93
pmol/l
—
5
25
5
25
2.02
0.73
1.0
1.1
—
—
—
0
0
100
894
1.22
0.73
4.2
3.2
0.00
0.00
estimate
-0.00
19
188
7
42
1.69
0.69
1.7
1.6
—
—
—
0
0
37
298
1.29
0.67
2.9
2.2
—
—
—
0
0
5
28
1.80
0.66
1.2
3.5
16.18
16.80
%
—
5
28
5
29
1.74
0.64
1.8
1.4
—
—
—
0
0
37
302
1.27
0.61
1.4
1.3
5.45
6.38
u/ml
0.07
15
119
11
72
1.56
0.60
1.8
1.3
—
—
—
0
0
65
567
1.21
0.59
2.6
2.5
—
—
—
0
0
167
1594
1.20
0.52
5.1
3.5
5.78
5.65
mmol/l
0.64
160
1476
77
694
1.17
0.48
4.0
3.0
0.00
0.01
estimate
0.50
16
163
21
165
1.30
0.47
2.0
1.7
—
—
—
0
0
53
466
1.18
0.44
4.4
3.4
0.00
0.01
estimate
0.50
18
178
5
32
1.58
0.42
1.6
1.8
13.40
12.94
%
—
5
32
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
9
71
1.28
0.36
6.2
3.8
2.03
1.57
%
—
9
71
19
154
1.26
0.35
5.4
2.1
30.32
32.12
u/l
0.13
19
124
19
231
0.81
0.34
1.5
1.6
2.97
3.46
mmol/l
1.24
13
158
14
109
1.30
0.34
2.4
2.2
—
23.07
—
0
8
31
267
1.19
0.33
3.2
2.9
9.56
806.76
ng/l
1.09
16
159
11
143
0.76
0.33
1.6
1.5
—
—
—
0
0
13
102
1.29
0.30
5.8
2.9
78.80
76.93
ml/min/173m2
—
5
42
7
56
1.26
0.29
1.6
1.3
—
—
—
0
0
19
161
1.20
0.25
2.4
1.7
—
—
—
0
0
14
115
1.23
0.24
1.9
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
61.27
—
0
10
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
0.29
—
0
10
0
10
0.00
0.21
0.0
1.1
—
25.60
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
3.2
—
1.15
—
0
7
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
18
157
1.16
0.18
1.3
1.3
14.57
103.93
u/ml
—
7
61
7
60
1.17
0.18
2.9
1.9
0.21
0.22
g/l
—
7
60
15
129
1.17
0.17
5.9
2.7
—
—
—
0
0
41
380
1.10
0.17
2.8
2.2
0.57
1.00
mg/l
1.35
34
281
13
111
1.18
0.16
1.5
1.5
—
—
—
0
0
25
227
1.11
0.15
2.5
2.5
0.82
0.70
ug/l
0.24
14
110
11
94
1.18
0.13
1.9
1.6
—
—
—
0
0
36
338
1.08
0.11
1.4
1.3
11.38
20.60
iu/ml
—
5
91
15
136
1.11
0.09
3.3
1.7
0.12
0.32
mg/l
—
9
60
10
88
1.14
0.08
1.4
1.5
64.77
51.69
ug/l
—
10
88
32
304
1.06
0.07
2.7
3.5
25.65
22.31
%
0.48
11
106
10
112
0.89
0.07
1.3
1.5
0.70
1.15
ratio
—
5
69
10
112
0.89
0.07
1.3
1.5
0.96
0.97
ratio
—
5
69
10
112
0.89
0.07
1.3
1.5
1.37
1.16
ratio
—
5
69
8
78
1.03
0.07
1.4
1.2
—
6.42
—
0
14
10
111
0.90
0.06
1.3
1.5
—
—
—
0
0
10
110
0.90
0.05
1.5
1.6
—
—
—
0
0
12
121
0.99
0.00
1.6
1.6
13.46
13.22
iu/l
0.02
12
97
12
117
1.03
0.00
1.0
1.1
0.97
0.87
g/l
0.64
12
117
13
126
1.03
0.00
6.3
5.0
—
—
—
0
0
10
96
1.04
0.00
1.6
1.8
—
—
—
0
0
12
116
1.04
0.00
1.0
1.1
1.43
1.52
g/l
0.99
12
116
55
545
1.01
0.00
3.1
2.6
0.00
0.00
estimate
-0.00
15
153
158
1585
0.99
0.00
3.8
3.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
3.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
42.87
—
0
8
0
8
0.00
0.00
0.0
3.1
—
—
—
0
0
6
59
1.02
-0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
118.00
—
0
9
5
53
0.94
-0.00
1.4
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
99
0.91
-0.00
7.3
4.3
23.98
24.06
mmol/l
—
9
99
6
64
0.94
-0.00
1.5
2.1
—
—
—
0
0
6
60
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
15.20
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
1361.96
—
0
9
0
5
0.00
-0.00
0.0
9.2
—
5.70
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
8.24
—
0
5
0
5
0.00
-0.00
0.0
8.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_ACNE_CONGLOBLATA and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACNE_CONGLOBLATA | 2.188 [1.59, 3.01] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 1137 males with L12_ACNE_CONGLOBLATA died.
Mortality risk
Mortality risk for people of age
years, who have L12_ACNE_CONGLOBLATA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.376% |
| 5 | No data | 2.552% |
| 10 | No data | 6.73% |
| 15 | No data | 12.466% |
| 20 | No data | 21.196% |
Relationships between endpoints
↥Index endpoint: L12_ACNE_CONGLOBLATA – Acne conglobata
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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