Hypoplasia of dental enamel, prenatal , including avohilmo

K11_HYPOPLASIA_ENAMEL_PRENATAL_INCLAVO

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 K00.41
  • Hospital discharge: ICD-10 K00.41
  • Cause of death: ICD-10 K00.41

3 out of 7 registries used, show all original rules.

181

4. Check minimum number of events

None

181

5. Include endpoints

None

181

6. Filter based on genotype QC (FinnGen only)

162

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF7

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3002 1580 1422
Only index persons 2001 1117 884
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.04
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population - 9.07 7.98
Only index persons 11.19 11.79 10.44

-FinnGen-

Key figures

All Female Male
Number of individuals 162 101 61
Unadjusted period prevalence (%) 0.03 0.04 0.03
Median age at first event (years) 13.22 17.22 6.60

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
175
Matched controls
1750
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K00.41
ICD-10 Finland
Prenatal enamel hypoplasia
+∞
253.2
175
*
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
18.1
77.9
79
76
127
Kela drug reimbursment
Transplant complication
17.3
39.4
35
25
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
13.4
34.0
35
32
L04AX01
ATC
azathioprine; systemic
13.8
33.7
34
30
H02AB04
ATC
methylprednisolone; systemic
9.4
28.4
38
50
K03.00
ICD-10 Finland
Approximal wear
8.1
28.0
44
70
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
8.0
23.1
35
53
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
7.6
21.9
35
56
A11CC03
ATC
alfacalcidol; systemic
20.3
21.5
32
19
EBA15
NOMESCO Finland
Extraction of multiple teeth
7.7
21.3
33
51
Z94.0
ICD-10 Finland
Kidney transplant status
23.8
21.3
30
15
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
7.8
20.3
31
47
ZX120
NOMESCO Finland
Intravenous
5.8
20.2
44
96
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.2
19.9
50
124
L04AD02
ATC
tacrolimus; systemic
17.7
19.8
31
21
H02AB09
ATC
hydrocortisone; systemic
6.5
19.5
36
67
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
39.4
19.5
24
7
L04AA06
ATC
mycophenolic acid; systemic
16.3
18.1
29
21
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
27.6
17.9
24
10
137
Kela drug reimbursment
Uraemia requiring dialysis
47.4
17.7
21
5
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
20.1
17.6
26
15
N04.80
ICD-10 Finland
Congenital nephrotic syndrome of the Finnish type
70.5
17.1
19
*
C08CA01
ATC
amlodipine; oral
6.3
17.1
32
60
WX408
NOMESCO Finland
General anesthesy, balanced
3.8
17.0
85
348
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
26.2
16.9
23
10
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
7.8
16.1
24
35
ZXD05
NOMESCO Finland
Urgent procedure
3.8
15.9
68
249
TK800
NOMESCO Finland
Hemodialysis
32.0
15.6
20
7
KAC00
NOMESCO Finland
Nephrectomy
32.0
15.6
20
7
A12AA04
ATC
calcium carbonate; oral
26.3
15.5
21
9
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
62.3
15.1
17
*
SAA03
NOMESCO Finland
Extended examination of mouth
4.2
14.9
138
819
Z99.2
ICD-10 Finland
Dependence on renal dialysis
87.6
14.8
16
*
K00.50
ICD-10 Finland
Dentinal dysplasia
39.8
14.8
18
5
L04AD01
ATC
ciclosporin; systemic
12.0
14.3
26
25
TPH07
NOMESCO Finland
Cathetrisation of artery
4.2
14.2
45
132
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.5
14.2
69
272
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.4
13.9
77
328
ZXE20
NOMESCO Finland
More than three and less than five hours
4.2
13.7
43
125
B03XA01
ATC
erythropoietin; parenteral
28.4
13.7
18
7
K03.66
ICD-10 Finland
Tooth plaque
3.6
13.5
58
210
Z2221
NOMESCO Finland
Medical doctor
3.3
13.1
73
310
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.1
13.0
30
68
TK820
NOMESCO Finland
Peritoneal dialysis
35.0
12.8
16
5
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
6.3
12.8
23
41
Z49.1
ICD-10 Finland
Extracorporeal dialysis
75.5
12.8
14
*
B05DA
ATC
Isotonic solutions
75.5
12.8
14
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
40.7
12.4
15
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
4.2
12.4
38
108
Z2446
NOMESCO Finland
Social worker
3.4
12.1
59
230
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
4.8
11.9
30
73
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
32.6
11.9
15
5
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
3.7
11.6
43
140
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.5
11.6
51
186
RD210, ,
NOMESCO Finland
4.7
11.4
29
71
ZYB02
NOMESCO Finland
Outreach service at unit of another specialty
11.7
11.1
20
19
Z49.2
ICD-10 Finland
Other dialysis
46.5
11.1
13
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.5
11.0
47
167
4AA09, ,
NOMESCO Finland
30.2
10.9
14
5
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
11.7
10.6
19
18
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
8.8
10.5
22
28
Z3226
NOMESCO Finland
Physiotherapist
2.9
10.2
70
327
602
Kela drug reimbursment
Children's severe malnutrition
4.8
10.2
25
59
WX882
NOMESCO Finland
High dependency care
3.3
10.2
47
175
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
3.7
10.2
37
118
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
42.7
10.1
12
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.2
10.1
22
47
205
Kela drug reimbursment
Chronic hypertension
8.2
10.1
22
30
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
8.2
10.1
22
30
1AB02, ,
NOMESCO Finland
14.5
9.9
16
12
ZXE10
NOMESCO Finland
More than one and less than three hours
2.9
9.9
69
325
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
5.3
9.8
21
44
ZXA00
NOMESCO Finland
Right side
3.7
9.8
35
110
3A013, ,
NOMESCO Finland
58.3
9.8
11
*
V03AE01
ATC
polystyrene sulfonate; oral
58.3
9.8
11
*
IGY02
NOMESCO Finland
Psychiatric monitoring contact
3.5
9.6
39
134
SCE00
NOMESCO Finland
Fissure sealant
2.9
9.4
57
248
WW500
NOMESCO Finland
Blood transfusion
5.2
9.3
20
42
R4110
NOMESCO Finland
Physiotherapy
2.7
9.3
73
364
KAS20
NOMESCO Finland
Allogenic transplantation of kidney from living donor
16.8
9.2
14
9
ZXE00
NOMESCO Finland
One hour or less
2.6
9.1
94
535
PA6AE
NOMESCO Finland
Ulrasound examination of neck vasculature
15.1
8.9
14
10
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
52.7
8.8
10
*
783, ,
NOMESCO Finland
52.7
8.8
10
*
FM2CE, ,
NOMESCO Finland
3.6
8.8
32
102
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
8.6
74
382
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.6
8.6
32
103
L04AA01
ATC
[U] ciclosporin
29.1
8.6
11
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.9
8.6
49
205
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.5
8.5
32
104
XF400
NOMESCO Finland
ECG with 12 standard connections
2.8
8.4
53
234
5AB14, ,
NOMESCO Finland
15.5
8.3
13
9
ZXD10
NOMESCO Finland
Scheduled procedure
2.5
8.3
81
443
ZX199
NOMESCO Finland
Other rote
8.8
8.3
17
21
K06.18
ICD-10 Finland
Another gingival hyperplasia
10.8
8.2
15
15
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.8
8.2
27
80
I15.8
ICD-10 Finland
Other secondary hypertension
23.3
8.1
11
5
XA800
NOMESCO Finland
Neuropsychological investigation
3.3
8.1
35
124
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.9
8.0
46
192
Z2445
NOMESCO Finland
Psychologist
3.0
7.7
39
152
R63.8
ICD-10 Finland
Other symptoms and signs concerning food and fluid intake
26.3
7.7
10
*
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
2.5
7.5
115
761
K07.24
ICD-10 Finland
Open bite
4.8
7.4
17
38
SAA04
NOMESCO Finland
Special examination of mouth
3.3
7.4
31
108
N18.8
ICD-10 Finland
Other chronic renal failure
12.8
7.2
12
10
SFA40
NOMESCO Finland
Restoration involving the entire crown of the tooth
3.8
7.1
23
67
IEP02
NOMESCO Finland
Child-centred family therapy
3.3
7.1
29
99
WW200
NOMESCO Finland
Immunization
7.2
7.0
16
24
R50.9
ICD-10 Finland
Fever, unspecified
2.4
6.8
64
338
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.7
6.8
23
69
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.8
6.8
22
64
WX892
NOMESCO Finland
Monitored bed care
3.2
6.7
28
97
C07AB02
ATC
metoprolol; systemic
4.2
6.6
18
46
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.4
6.6
56
282
Z94.4
ICD-10 Finland
Liver transplant status
15.0
6.5
10
7
TK823
NOMESCO Finland
Peritoneal permeability analysis
72.4
6.5
7
*
F59
ICD-10 Finland
Unspecified behavioural syndromes associated with physiological disturbances and physical factors
9.8
6.4
12
13
U14
ICPC
Kidney symptom/complaint
18.9
6.3
9
5
JAF10
NOMESCO Finland
Repair of umbilical hernia
27.8
6.3
8
*
Z3231
NOMESCO Finland
Registered nurse
2.2
6.2
82
497
R4190
NOMESCO Finland
Nutritional therapy
2.5
6.2
46
217
RS121, ,
NOMESCO Finland
7.1
6.2
14
21
K02.0
ICD-10 Finland
Caries limited to enamel
2.2
6.1
91
577
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.5
6.1
47
225
A41.9
ICD-10 Finland
Sepsis, unspecified
5.8
6.0
16
30

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
44
87
6.42
22.58
5.6
2.2
68.10
103.76
au/ml
1.28
25
42
44
89
6.27
22.03
5.5
2.1
—
—
—
0
0
47
105
5.75
21.13
4.5
2.2
219.19
114.69
u/ml
1.00
26
47
30
20
17.84
19.29
71.1
53.8
6.16
6.77
ug/l
0.91
30
20
53
147
4.74
18.32
27.9
9.0
72.07
47.37
ng/l
1.87
53
142
30
50
7.03
17.98
2.7
2.5
—
—
—
0
0
26
16
18.84
17.18
9.8
6.9
55914.29
1947280.00
u/ml
—
7
5
34
71
5.70
16.21
2.2
1.9
—
—
—
0
0
39
94
5.05
15.82
17.6
10.2
348.26
307.69
mg/l
0.09
34
77
25
21
13.68
14.63
3.4
2.6
—
—
—
0
0
55
186
3.85
14.23
4.2
1.9
—
—
—
0
0
63
238
3.57
13.76
52.9
11.9
0.76
0.81
mmol/l
4.98
63
222
63
266
3.14
11.17
8.4
4.7
—
—
—
0
0
48
172
3.47
11.14
8.0
5.7
59.08
63.99
e9/l
0.48
38
101
58
234
3.21
11.11
11.2
7.4
1.48
1.41
%
0.26
58
223
82
414
2.85
10.39
9.0
4.0
—
—
—
0
0
18
17
11.65
10.05
3.7
2.6
—
—
—
0
0
79
408
2.71
9.37
24.3
9.7
85.11
85.42
%
0.04
79
399
43
164
3.15
8.87
3.7
1.8
—
—
—
0
0
20
30
7.38
8.66
4.9
4.4
0.65
0.57
index
0.14
20
30
32
103
3.58
8.62
2.8
1.8
18.03
19.92
ng/l
0.34
32
103
18
37
5.31
8.57
1.7
1.3
—
—
—
0
0
39
145
3.17
8.36
2.1
1.4
—
—
—
0
0
20
32
6.91
8.30
1.5
1.5
—
—
—
0
0
72
375
2.56
8.17
48.0
13.0
—
—
—
0
0
93
555
2.44
7.76
8.3
3.9
—
—
estimate
—
0
0
48
211
2.76
7.58
27.0
8.0
6.53
5.20
umol/l
0.46
40
170
72
390
2.44
7.36
41.2
11.4
23.47
23.33
mmol/l
0.24
72
390
24
71
3.76
7.27
5.0
4.6
0.17
0.51
e9/l
3.41
15
45
24
72
3.70
7.13
4.1
2.2
—
—
—
0
0
24
72
3.70
7.13
4.1
2.2
—
—
—
0
0
24
72
3.70
7.13
4.1
2.2
—
—
—
0
0
24
72
3.70
7.13
4.1
2.2
—
—
—
0
0
74
412
2.38
7.06
48.6
12.0
0.63
0.71
mmol/l
0.10
68
318
43
186
2.74
6.96
7.3
4.6
0.20
0.20
g/l
0.09
43
178
73
413
2.32
6.63
49.9
12.0
5.51
5.71
kpa
1.78
73
404
73
416
2.30
6.49
50.8
11.9
7.38
7.37
ph
0.95
64
266
86
530
2.22
6.27
25.1
9.9
29.33
27.87
umol/l
0.08
81
495
26
90
3.22
6.20
10.9
6.0
0.05
0.07
%
0.12
21
29
69
398
2.21
5.84
48.8
11.9
5.42
5.30
kpa
0.29
69
390
61
335
2.26
5.81
19.2
6.5
1.22
1.26
inr
0.09
55
279
67
384
2.21
5.74
45.5
11.7
—
—
—
0
0
22
73
3.30
5.60
5.5
4.4
1311.12
1741.37
e6/l
0.74
17
49
15
29
5.55
5.54
2.9
3.2
27.33
35.55
mmol/l
0.53
15
29
109
767
2.12
5.36
32.2
11.4
—
—
—
0
0
24
87
3.04
5.29
32.6
20.9
0.64
0.60
%
0.18
24
87
94
633
2.05
5.13
23.8
9.9
—
—
—
0
0
54
295
2.20
5.13
15.8
3.6
7.38
7.39
ph
0.21
41
198
82
528
2.04
5.04
18.9
4.4
0.15
0.24
e6/l
0.51
65
378
12
20
6.36
5.01
24.9
5.2
9.64
4.10
pmol/l
1.45
12
20
17
52
3.51
4.89
4.1
2.4
—
—
—
0
0
11
17
6.82
4.85
1.2
2.2
1.55
0.89
iu/ml
—
6
10
57
325
2.12
4.82
2.1
1.8
—
—
—
0
0
36
171
2.39
4.71
49.8
16.9
105.56
105.68
mmol/l
0.07
36
171
11
20
5.79
4.36
1.0
1.2
—
—
—
0
0
20
73
2.96
4.35
1.7
1.6
—
—
—
0
0
69
436
1.96
4.33
48.7
12.0
4.90
4.97
kpa
0.54
69
425
62
380
1.98
4.23
5.8
2.7
—
—
—
0
0
49
277
2.07
4.18
13.6
4.9
3.61
2.36
mg/l
0.23
43
204
15
47
3.40
4.16
3.7
5.6
—
—
—
0
0
8
10
8.32
4.10
3.5
1.5
30.13
32.60
pg
—
8
10
17
59
3.08
4.03
1.7
1.2
—
—
—
0
0
12
27
4.69
4.02
20.3
5.2
—
—
—
0
0
111
835
1.90
3.99
8.8
3.9
53.07
55.96
ug/l
0.12
106
809
11
23
5.03
3.94
1.2
1.1
—
—
—
0
0
11
23
5.03
3.94
1.2
1.1
—
—
—
0
0
9
15
6.26
3.87
3.2
2.4
—
—
—
0
0
59
366
1.92
3.83
15.7
4.2
2.40
1.84
e6/l
0.15
40
203
127
1009
1.94
3.74
37.0
11.9
0.28
0.22
e9/l
0.50
117
839
83
582
1.81
3.62
20.6
4.5
66.33
27.97
e6/l
0.47
66
430
11
26
4.44
3.57
20.2
3.8
7.39
7.39
ph
0.03
11
26
112
862
1.83
3.56
6.8
3.2
2.50
2.61
mmol/l
0.74
107
825
16
58
2.94
3.53
1.3
1.4
—
—
—
0
0
130
1053
1.91
3.46
37.6
12.8
3.16
3.62
e9/l
2.04
117
855
111
860
1.79
3.37
6.8
3.1
1.45
1.42
mmol/l
0.33
106
821
11
28
4.12
3.35
1.3
1.3
3.33
3.94
u/ml
—
6
16
18
72
2.67
3.33
5.5
4.4
476.38
609.04
e6/l
0.45
13
48
126
1016
1.86
3.33
32.6
10.7
2.50
2.51
e9/l
0.04
118
857
17
66
2.75
3.32
45.2
21.3
74.14
72.52
%
0.18
17
66
93
688
1.75
3.29
25.5
5.7
14.90
68.01
e6/l
1.53
67
447
9
19
4.93
3.28
21.9
2.6
1.07
1.10
mmol/l
—
9
19
123
987
1.83
3.27
33.0
10.8
0.03
0.04
e9/l
2.04
113
798
69
469
1.78
3.27
75.2
17.1
24.49
24.51
mmol/l
0.02
69
469
18
73
2.63
3.25
6.1
4.4
93.69
209.14
e6/l
2.98
13
49
40
229
1.97
3.24
4.1
1.7
—
—
—
0
0
123
989
1.82
3.23
33.0
10.8
0.59
0.58
e9/l
0.08
113
801
69
472
1.76
3.18
10.8
4.0
—
—
—
0
0
6
8
7.71
3.08
9.7
7.7
313.17
251.00
ug/l
—
6
8
7
12
6.02
3.05
1.3
1.3
—
—
—
0
0
9
21
4.46
3.04
1.0
1.1
—
—
—
0
0
9
21
4.46
3.04
1.0
1.0
—
—
—
0
0
23
109
2.28
3.01
2.3
1.3
—
—
—
0
0
17
70
2.58
2.98
6.7
4.5
42.81
37.88
%
0.66
17
70
16
64
2.65
2.97
51.0
22.5
74.38
73.82
%
0.06
16
64
6
9
6.85
2.89
1.0
1.7
9.50
8.33
umol/l
—
6
9
12
39
3.23
2.83
5.8
10.3
37.00
36.97
°c
0.38
12
39
8
18
4.60
2.83
1.4
2.9
—
—
—
0
0
7
14
5.16
2.75
1.6
1.3
77.00
119.64
pmol/l
—
7
14
106
844
1.65
2.62
36.8
10.2
5.79
5.98
mmol/l
0.34
98
783
8
20
4.14
2.60
1.1
1.3
—
—
—
0
0
6
11
5.60
2.56
1.2
1.4
—
—
—
0
0
117
960
1.66
2.52
40.7
13.2
0.00
0.00
e9/l
0.80
97
723
68
488
1.64
2.52
2.1
2.4
—
—
—
0
0
19
90
2.25
2.49
4.4
1.8
0.00
0.00
estimate
—
9
22
9
27
3.46
2.43
8.3
2.1
1.49
1.77
mmol/l
—
9
27
16
71
2.38
2.42
1.6
1.3
0.21
0.21
g/l
0.01
16
66
6
12
5.13
2.42
1.2
1.0
—
—
—
0
0
6
12
5.13
2.42
27.7
2.3
5.32
5.91
mmol/l
—
6
12
8
22
3.76
2.39
24.5
4.0
4.75
4.62
kpa
—
8
22
8
22
3.76
2.39
24.5
4.0
10.96
9.18
kpa
—
8
22
7
17
4.24
2.38
1.6
1.3
—
—
—
0
0
16
72
2.35
2.36
1.6
1.2
1.08
1.17
g/l
0.54
16
66
13
53
2.57
2.33
55.2
26.0
11.04
12.08
%
0.65
13
53
158
1425
2.12
2.32
43.8
11.5
59.42
53.52
umol/l
1.04
158
1402
6
13
4.74
2.29
1.2
1.0
—
—
—
0
0
6
13
4.74
2.29
1.2
1.0
—
—
—
0
0
6
13
4.74
2.29
1.2
1.0
—
—
—
0
0
7
19
3.79
2.17
2.0
2.2
—
—
—
0
0
24
132
1.95
2.17
2.5
3.0
25.74
32.93
u/l
0.60
19
110
9
31
3.00
2.10
1.9
1.7
—
—
—
0
0
6
15
4.10
2.05
3.2
1.6
2157.67
1151.80
u/ml
—
6
15
46
313
1.64
2.05
15.3
4.6
—
—
—
0
0
9
34
2.73
1.89
1.1
1.4
—
—
—
0
0
70
535
1.51
1.88
2.3
1.8
—
—
—
0
0
16
80
2.10
1.87
59.2
20.6
0.69
0.67
%
0.11
16
80
87
702
1.48
1.76
2.8
1.8
1.49
1.45
g/l
0.13
61
351
16
82
2.05
1.76
59.3
20.1
0.99
0.90
%
0.52
16
82
16
82
2.05
1.76
59.2
20.2
95.97
95.52
%
0.12
16
82
11
48
2.38
1.74
5.3
3.3
0.82
1.03
e9/l
0.32
11
48
53
389
1.52
1.69
2.0
1.8
—
—
—
0
0
108
914
1.47
1.69
3.8
2.6
5.18
5.29
mmol/l
1.03
102
838
11
49
2.33
1.67
1.4
1.3
352.33
354.97
ug/g
—
6
29
7
25
2.87
1.67
1.4
1.6
—
—
—
0
0
10
42
2.46
1.65
3.5
1.9
—
—
—
0
0
10
43
2.40
1.62
4.5
5.4
3.39
34.76
u/ml
—
10
43
24
146
1.75
1.61
2.9
2.6
5.21
5.46
u/l
0.06
12
80
81
656
1.44
1.56
10.3
3.7
6.27
6.37
ph
0.24
33
300
97
815
1.43
1.51
7.7
3.8
33.59
35.39
mmol/mol
2.17
92
778
6
136
0.42
1.48
1.2
2.2
—
—
—
0
0
5
16
3.18
1.45
1.6
2.5
3.90
5.82
ug/l
—
5
16
148
1356
1.59
1.41
72.3
15.9
4.05
3.97
mmol/l
1.50
142
1324
37
261
1.53
1.41
2.0
1.6
—
—
—
0
0
7
29
2.47
1.40
4.0
5.8
26.72
23.66
ug/l
—
7
29
10
193
0.49
1.40
2.1
1.8
—
—
—
0
0
10
192
0.49
1.38
2.1
1.8
—
—
—
0
0
6
23
2.66
1.38
9.0
2.6
3.02
3.14
e9/l
—
6
23
5
17
3.00
1.37
13.6
4.0
5.28
4.91
kpa
—
5
17
10
191
0.49
1.36
2.1
1.8
—
—
—
0
0
10
191
0.49
1.36
2.1
1.8
—
—
—
0
0
28
191
1.55
1.24
3.0
2.5
—
—
—
0
0
6
126
0.46
1.22
1.0
1.2
0.12
1.66
u/ml
—
6
74
5
19
2.68
1.22
9.2
8.5
—
—
—
0
0
22
142
1.63
1.21
3.0
2.6
13.87
8.52
iu/l
0.25
12
89
8
155
0.49
1.20
2.1
1.8
—
—
—
0
0
8
38
2.16
1.20
1.3
1.1
—
—
—
0
0
44
334
1.42
1.17
2.1
1.6
94.42
95.01
pmol/l
0.03
20
173
10
51
2.02
1.13
4.9
6.1
3.18
2.25
ug/l
—
10
51
113
1003
1.36
1.12
18.1
4.5
—
—
—
0
0
91
782
1.34
1.12
13.6
3.9
53.43
0.00
estimate
0.48
23
135
28
196
1.51
1.11
2.4
1.6
240.00
565.93
titre
—
5
27
10
177
0.54
1.09
2.1
1.8
—
—
—
0
0
91
785
1.33
1.08
13.7
4.0
0.00
0.00
estimate
-0.00
23
135
5
22
2.31
1.04
2.6
5.5
1.58
1.52
mmol/l
—
5
22
5
22
2.31
1.04
1.0
1.0
—
—
—
0
0
9
47
1.96
1.04
1.3
1.2
—
—
—
0
0
90
781
1.31
1.00
13.7
3.9
0.00
0.00
estimate
-0.00
23
138
9
50
1.84
0.98
1.8
1.1
—
—
—
0
0
17
109
1.62
0.98
1.4
1.2
—
—
—
0
0
67
563
1.31
0.92
2.3
2.2
—
—
—
0
0
157
1496
1.48
0.81
62.1
18.7
335.50
334.64
g/l
0.55
157
1488
0
26
0.00
0.79
0.0
2.0
—
—
—
0
0
13
195
0.64
0.78
1.2
1.3
0.52
0.97
u/ml
0.48
13
146
13
195
0.64
0.78
1.2
1.3
1.63
5.26
u/ml
1.88
13
153
46
376
1.30
0.77
11.0
3.8
0.00
0.00
estimate
-0.00
21
135
154
1467
1.41
0.74
30.5
9.0
—
—
—
0
0
12
77
1.60
0.70
5.2
6.1
—
—
—
0
0
11
70
1.61
0.67
5.7
6.5
—
—
—
0
0
5
28
1.81
0.66
4.4
2.0
—
—
—
0
0
8
51
1.60
0.61
4.1
1.6
1.02
1.02
ratio
—
8
45
24
185
1.34
0.60
2.1
2.7
33.75
18.95
ng/l
—
8
70
16
116
1.42
0.57
1.0
1.0
—
—
—
0
0
12
82
1.50
0.56
5.3
5.8
134.57
495.06
e6/l
—
7
62
12
83
1.48
0.53
5.3
5.7
1.71
5.44
e6/l
—
7
62
15
109
1.41
0.53
2.5
1.6
—
—
—
0
0
157
1516
1.35
0.52
47.4
12.8
23.17
22.49
mg/l
0.11
124
1152
11
75
1.50
0.52
1.1
1.2
—
—
—
0
0
7
49
1.45
0.46
5.1
5.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
7340.90
—
0
10
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
8
60
1.35
0.41
2.0
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
8
61
1.33
0.40
2.0
1.7
—
—
—
0
0
11
80
1.40
0.39
1.2
1.2
—
—
—
0
0
11
81
1.38
0.37
1.2
1.2
—
—
—
0
0
5
80
0.61
0.36
1.0
1.0
—
—
—
0
0
6
42
1.44
0.36
1.2
1.2
0.74
0.80
g/l
—
6
42
29
337
0.83
0.35
1.3
1.3
—
—
—
0
0
12
152
0.77
0.31
1.2
1.3
15.00
138.42
u/ml
—
5
41
13
103
1.28
0.29
15.0
3.2
—
—
—
0
0
14
172
0.80
0.29
1.3
1.2
1.26
5.72
u/ml
—
5
62
39
349
1.15
0.28
1.6
2.0
—
—
—
0
0
11
87
1.28
0.25
1.1
1.1
—
—
—
0
0
10
79
1.28
0.23
6.3
1.8
50.06
51.77
%
—
10
79
33
365
0.88
0.22
7.7
3.4
1.02
1.02
kg/l
0.03
21
251
5
41
1.23
0.22
1.2
1.1
1.64
1.53
g/l
—
5
41
8
102
0.77
0.22
3.4
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
6
51
1.18
0.19
1.3
1.3
—
—
—
0
0
132
1288
1.10
0.18
5.7
4.3
2.25
2.01
mu/l
1.75
127
1226
7
61
1.15
0.18
1.1
1.4
1.22
4.46
u/ml
—
7
46
14
120
1.18
0.17
1.1
1.1
—
47.36
—
0
10
14
121
1.17
0.15
1.5
1.3
—
—
—
0
0
12
136
0.87
0.11
1.4
1.6
—
—
—
0
0
12
135
0.88
0.10
1.8
2.2
—
—
—
0
0
5
46
1.09
0.09
1.6
1.6
—
—
—
0
0
116
1180
0.95
0.08
4.1
3.8
14.51
14.43
pmol/l
0.11
105
1091
5
60
0.83
0.08
2.0
2.7
4.86
0.47
nmol/l
—
5
55
33
313
1.07
0.08
2.3
2.0
—
—
—
0
0
74
720
1.05
0.08
1.8
1.9
2.93
3.75
u/ml
—
9
110
167
1677
0.91
0.07
70.3
20.7
126.19
130.67
g/l
3.44
167
1663
8
73
1.10
0.07
1.0
1.1
—
—
—
0
0
167
1675
0.93
0.07
69.0
20.1
86.54
85.95
fl
0.81
167
1661
167
1675
0.93
0.07
69.0
20.1
29.09
28.88
pg
0.74
167
1661
167
1673
0.96
0.07
69.1
20.3
277.86
276.99
e9/l
0.05
167
1598
7
82
0.85
0.07
1.1
1.1
—
—
—
0
0
49
505
0.96
0.06
10.6
3.4
0.00
0.02
estimate
0.80
20
116
19
181
1.06
0.03
1.4
1.3
10.24
11.29
iu/ml
—
7
41
37
360
1.04
0.03
11.6
2.9
0.00
0.01
estimate
0.50
19
119
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
20.17
—
0
6
0
6
0.00
-0.00
0.0
3.7
—
0.60
—
0
6
9
96
0.93
-0.00
1.3
1.2
—
—
—
0
0
6
64
0.94
-0.00
1.8
2.0
0.56
5.88
u/ml
—
6
64
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
86.32
—
0
5
8
80
1.00
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
15.90
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
15.2
—
35.83
—
0
6
0
6
0.00
-0.00
0.0
2.3
—
219.33
—
0
6

Mortality – FinRegistry

Association

Association between endpoint K11_HYPOPLASIA_ENAMEL_PRENATAL_INCLAVO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_HYPOPLASIA_ENAMEL_PRENATAL_INCLAVO.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: K11_HYPOPLASIA_ENAMEL_PRENATAL_INCLAVO – Hypoplasia of dental enamel, prenatal , including avohilmo

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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