Hypoplasia of dental enamel, prenatal

K11_HYPOPLASIA_ENAMEL_PRENATAL

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K00.41
  • Cause of death: ICD-10 K00.41

2 out of 7 registries used, show all original rules.

70

4. Check minimum number of events

None

70

5. Include endpoints

None

70

6. Filter based on genotype QC (FinnGen only)

62

Control definitions (FinnGen only)

Control exclude
K11_MIH

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 444 197 247
Only index persons 110 54 56
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population - 4.63 4.01
Only index persons 8.81 9.75 7.90

-FinnGen-

Key figures

All Female Male
Number of individuals 62 26 36
Unadjusted period prevalence (%) 0.01 0.01 0.02
Median age at first event (years) 4.19 4.63 3.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
69
Matched controls
690
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K00.41
ICD-10 Finland
Prenatal enamel hypoplasia
+∞
99.1
69
*
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
+∞
60.6
49
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
23.0
37.0
34
28
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
23.4
36.8
33
26
ZX120
NOMESCO Finland
Intravenous
19.9
35.9
38
40
H02AB09
ATC
hydrocortisone; systemic
18.2
32.2
34
35
ZXD05
NOMESCO Finland
Urgent procedure
16.5
31.9
47
79
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
15.6
30.9
45
74
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
18.9
30.6
30
27
L04AX01
ATC
azathioprine; systemic
96.5
30.5
32
6
127
Kela drug reimbursment
Transplant complication
68.0
29.6
33
9
EBA15
NOMESCO Finland
Extraction of multiple teeth
17.5
29.3
30
29
L04AD02
ATC
tacrolimus; systemic
97.6
27.6
29
5
A11CC03
ATC
alfacalcidol; systemic
73.7
27.4
30
7
Z94.0
ICD-10 Finland
Kidney transplant status
115.0
27.3
28
*
H02AB04
ATC
methylprednisolone; systemic
48.1
26.7
32
12
TPH07
NOMESCO Finland
Cathetrisation of artery
12.8
26.5
43
79
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
33.9
25.7
34
19
K03.00
ICD-10 Finland
Approximal wear
33.9
25.7
34
19
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
15.0
25.4
28
30
ZXE20
NOMESCO Finland
More than three and less than five hours
12.2
25.2
38
63
Z2221
NOMESCO Finland
Medical doctor
13.1
24.1
52
131
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
168.8
23.2
23
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
76.4
23.0
25
5
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
10.7
22.1
46
109
WX408
NOMESCO Finland
General anesthesy, balanced
15.9
21.7
59
187
Z2446
NOMESCO Finland
Social worker
11.1
21.7
50
132
L04AA06
ATC
mycophenolic acid; systemic
45.1
21.6
26
9
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
84.4
21.5
23
*
SAA03
NOMESCO Finland
Extended examination of mouth
48.6
21.4
67
281
WX404
NOMESCO Finland
Intravenous generell anesthesy
13.7
21.1
57
178
ZXE10
NOMESCO Finland
More than one and less than three hours
11.2
20.9
52
148
N04.80
ICD-10 Finland
Congenital nephrotic syndrome of the Finnish type
+∞
20.9
19
*
137
Kela drug reimbursment
Uraemia requiring dialysis
276.0
20.8
20
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
10.2
20.7
33
57
TPH04
NOMESCO Finland
Cathetrisation of vein
9.4
20.1
39
84
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
10.8
19.9
28
41
KAC00
NOMESCO Finland
Nephrectomy
138.0
19.7
20
*
Z3226
NOMESCO Finland
Physiotherapist
10.7
19.4
53
163
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
73.9
19.2
21
*
L04AD01
ATC
ciclosporin; systemic
31.7
19.1
25
12
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
9.9
19.0
51
153
K03.66
ICD-10 Finland
Tooth plaque
8.9
19.0
42
103
R4110
NOMESCO Finland
Physiotherapy
12.8
18.8
58
201
TK800
NOMESCO Finland
Hemodialysis
238.9
18.5
18
*
Z2445
NOMESCO Finland
Psychologist
9.1
18.5
32
60
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
9.9
18.2
27
42
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
8.8
18.2
33
65
C08CA01
ATC
amlodipine; oral
19.6
18.0
28
23
IGY02
NOMESCO Finland
Psychiatric monitoring contact
8.8
17.9
32
62
A12AA04
ATC
calcium carbonate; oral
55.1
17.5
20
5
Z99.2
ICD-10 Finland
Dependence on renal dialysis
+∞
17.4
16
*
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
8.1
17.3
38
91
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
7.9
16.9
37
88
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
31.4
16.9
22
10
GD1AA
NOMESCO Finland
Thorax X-ray examination
8.6
16.4
51
171
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
110.6
16.4
17
*
602
Kela drug reimbursment
Children's severe malnutrition
10.0
16.4
23
33
ZXA00
NOMESCO Finland
Right side
8.6
16.4
28
51
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
7.7
16.3
36
86
TK820
NOMESCO Finland
Peritoneal dialysis
204.5
16.2
16
*
ZXD10
NOMESCO Finland
Scheduled procedure
10.4
16.1
57
216
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
59.5
16.0
18
*
B03XA01
ATC
erythropoietin; parenteral
59.5
16.0
18
*
FM2CE, ,
NOMESCO Finland
7.9
15.8
30
61
ZXE30
NOMESCO Finland
More than five and less than seven hours
9.4
15.6
23
35
B05DA
ATC
Isotonic solutions
+∞
15.1
14
*
RD210, ,
NOMESCO Finland
9.3
15.0
22
33
XF400
NOMESCO Finland
ECG with 12 standard connections
7.0
14.8
43
132
ZYB02
NOMESCO Finland
Outreach service at unit of another specialty
32.0
14.8
19
8
WX882
NOMESCO Finland
High dependency care
6.8
14.5
41
122
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
94.1
14.2
15
*
Z49.2
ICD-10 Finland
Other dialysis
+∞
14.0
13
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
+∞
14.0
13
*
ZXE00
NOMESCO Finland
One hour or less
9.0
13.7
57
239
205
Kela drug reimbursment
Chronic hypertension
21.0
13.7
20
13
Z01.0
ICD-10 Finland
Examination of eyes and vision
6.5
13.6
43
140
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
17.2
13.2
21
17
4AA09, ,
NOMESCO Finland
86.3
13.1
14
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
157.5
12.9
13
*
Z3231
NOMESCO Finland
Registered nurse
7.8
12.4
56
245
KAS20
NOMESCO Finland
Allogenic transplantation of kidney from living donor
57.5
12.4
14
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
16.0
12.3
20
17
XA800
NOMESCO Finland
Neuropsychological investigation
6.1
11.8
28
69
1AB02, ,
NOMESCO Finland
25.5
11.8
16
8
WW500
NOMESCO Finland
Blood transfusion
14.3
11.8
20
19
ZX199
NOMESCO Finland
Other rote
20.0
11.6
17
11
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
6.7
11.5
23
48
K06.18
ICD-10 Finland
Another gingival hyperplasia
26.8
11.3
15
7
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
11.0
11.2
22
28
SAA04
NOMESCO Finland
Special examination of mouth
12.9
11.2
20
21
5AB14, ,
NOMESCO Finland
71.4
11.0
12
*
3A013, ,
NOMESCO Finland
128.8
10.7
11
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
128.8
10.7
11
*
PA6AE
NOMESCO Finland
Ulrasound examination of neck vasculature
28.7
10.7
14
6
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
12.0
10.4
19
21
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
6.7
10.0
19
37
SCE00
NOMESCO Finland
Fissure sealant
4.9
9.8
34
114
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
115.2
9.7
10
*
L04AA01
ATC
[U] ciclosporin
115.2
9.7
10
*
783, ,
NOMESCO Finland
115.2
9.7
10
*
WX402
NOMESCO Finland
General anaesthesia
5.1
9.6
47
205
C07AB02
ATC
metoprolol; systemic
13.5
9.4
16
15
ZXA05
NOMESCO Finland
Left side
5.9
9.4
21
48
Z3229
NOMESCO Finland
Other healthcare associate professional
5.2
9.4
26
72
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
10.6
9.3
18
22
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
8.9
9.2
20
30
WX892
NOMESCO Finland
Monitored bed care
5.4
9.2
23
58
K02.0
ICD-10 Finland
Caries limited to enamel
4.8
9.1
45
195
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
10.9
9.0
17
20
Z94.4
ICD-10 Finland
Liver transplant status
57.6
8.9
10
*
I15.8
ICD-10 Finland
Other secondary hypertension
32.1
8.8
11
*
V03AE01
ATC
polystyrene sulfonate; oral
102.0
8.6
9
*
K00.50
ICD-10 Finland
Dentinal dysplasia
+∞
8.5
8
*
F59
ICD-10 Finland
Unspecified behavioural syndromes associated with physiological disturbances and physical factors
20.3
8.4
12
7
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.5
8.4
30
101
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
4.3
8.3
37
146
K06.19
ICD-10 Finland
Gingival hyperplasia UNS
38.3
8.3
10
*
WW200
NOMESCO Finland
Immunization
13.2
8.2
14
13
SFA40
NOMESCO Finland
Restoration involving the entire crown of the tooth
10.0
8.2
16
20
XF600
NOMESCO Finland
Bloodpressure measurement
4.5
8.1
27
86
K07.24
ICD-10 Finland
Open bite
10.9
8.0
15
17
RS220, ,
NOMESCO Finland
10.9
8.0
15
17
R50.9
ICD-10 Finland
Fever, unspecified
4.2
8.0
41
178
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
12.2
8.0
14
14
N18.8
ICD-10 Finland
Other chronic renal failure
21.4
7.9
11
6
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
4.2
7.9
33
124
R63.8
ICD-10 Finland
Other symptoms and signs concerning food and fluid intake
28.8
7.8
10
*
UKC02
NOMESCO Finland
Cystoscopy
15.8
7.7
12
9
IEP02
NOMESCO Finland
Child-centred family therapy
4.6
7.7
24
72
JAF10
NOMESCO Finland
Repair of umbilical hernia
89.3
7.6
8
*
U14
ICPC
Kidney symptom/complaint
89.3
7.6
8
*
R4190
NOMESCO Finland
Nutritional therapy
4.0
7.5
37
155
ZXA10
NOMESCO Finland
Bilateral
4.4
7.5
25
79
TK823
NOMESCO Finland
Peritoneal permeability analysis
+∞
7.4
7
*
RS121, ,
NOMESCO Finland
12.0
7.4
13
13
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.0
7.4
32
122
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
9.2
7.4
15
20
SAB03
NOMESCO Finland
Oral health check
0.3
7.3
32
533
K02.1
ICD-10 Finland
Caries of dentine
4.1
7.2
47
236
A41.9
ICD-10 Finland
Sepsis, unspecified
11.1
7.2
13
14
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.9
7.1
33
132
KA1AE
NOMESCO Finland
Kidney ultrasound examination
19.1
7.0
10
6
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.5
7.0
21
61
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
6.6
6.9
18
35
Z01.8
ICD-10 Finland
Other specified special examinations
4.0
6.9
27
95
V03AG01
ATC
sodium cellulose phosphate; systemic
44.5
6.9
8
*
XF602
NOMESCO Finland
Bloodpressure monitoring
25.5
6.9
9
*
SPAT1262
SPAT
Handing over of treatment supplies
8.0
6.8
15
23
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
3.7
6.8
34
142
WX110
NOMESCO Finland
Infiltration anesthesia
5.5
6.8
59
358
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
7.7
6.6
15
24
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
4.7
6.6
18
48
GD1LA
NOMESCO Finland
GD
76.6
6.5
7
*
XX4AW, ,
NOMESCO Finland
7.4
6.4
15
25
B34.9
ICD-10 Finland
Viral infection, unspecified
4.6
6.4
18
49
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
10.1
6.4
12
14
B03XA02
ATC
darbepoetin alfa; parenteral
+∞
6.3
6
*
UDC00
NOMESCO Finland
Ear microscopy
5.9
6.1
17
36
C09AA02
ATC
enalapril; systemic
9.4
6.1
12
15
C03DA01
ATC
spironolactone; oral
9.4
6.1
12
15
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.7
6.1
27
103

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
35
40
16.73
30.96
6.7
2.5
66.90
91.63
au/ml
0.57
24
19
35
40
16.73
30.96
6.7
2.4
—
—
—
0
0
29
30
15.95
26.99
2.8
2.4
—
—
—
0
0
34
46
13.60
26.39
5.8
2.4
132.45
89.25
u/ml
0.56
20
16
30
34
14.84
26.28
2.3
1.9
—
—
—
0
0
46
100
11.80
24.26
12.5
3.3
18.26
20.73
%
0.81
46
100
49
118
11.88
23.50
68.9
19.1
1.39
1.01
mg/l
4.69
49
118
37
72
9.92
20.99
5.6
2.1
—
—
—
0
0
54
162
11.73
20.58
12.6
4.8
—
—
—
0
0
24
7
51.23
20.58
3.5
2.7
—
—
—
0
0
52
150
11.01
20.54
11.2
4.1
—
—
—
0
0
42
99
9.29
19.90
30.3
9.3
6.85
5.78
umol/l
0.28
34
76
47
125
9.66
19.89
9.8
4.1
—
—
—
0
0
49
139
9.71
19.39
24.2
6.8
32.59
31.12
s
0.46
49
139
56
185
11.76
19.09
11.8
4.7
—
—
estimate
—
0
0
34
73
8.21
17.19
4.2
1.8
—
—
—
0
0
34
73
8.21
17.19
17.4
8.5
23.21
22.59
s
0.16
34
73
40
103
7.86
16.93
8.8
6.2
57.63
66.37
e9/l
0.73
34
56
29
60
7.61
14.94
2.3
1.5
—
—
—
0
0
40
115
6.90
14.76
17.8
3.8
7.38
7.38
ph
0.01
34
78
59
248
10.52
14.45
66.7
8.8
1.40
1.46
mmol/l
1.12
59
237
31
73
6.90
13.96
2.8
1.8
18.06
20.04
ng/l
0.31
31
73
40
120
6.55
13.95
8.3
3.3
232.88
301.67
nmol/l
1.75
40
120
31
74
6.79
13.74
2.4
1.9
—
—
—
0
0
17
7
31.51
13.23
3.4
2.6
—
—
—
0
0
17
7
31.51
13.23
1.5
1.1
—
—
—
0
0
40
125
6.23
13.19
7.8
2.4
—
—
—
0
0
24
48
7.13
12.56
1.9
1.5
—
—
—
0
0
25
53
6.83
12.34
1.8
1.8
—
—
—
0
0
56
251
7.53
11.90
60.1
12.0
—
—
—
0
0
22
43
7.04
11.70
4.4
2.0
—
—
—
0
0
22
43
7.04
11.70
4.4
2.0
—
—
—
0
0
22
43
7.04
11.70
4.4
2.0
—
—
—
0
0
22
43
7.04
11.70
4.4
2.0
—
—
—
0
0
57
262
7.76
11.70
48.6
9.5
23.68
23.20
mmol/l
1.09
57
262
47
186
5.79
11.38
10.8
3.7
1.22
1.15
mmol/l
0.23
47
177
26
63
6.02
11.08
15.4
12.1
4001.00
1154.04
ng/l
1.23
26
58
16
10
20.33
10.99
1.8
1.2
—
—
—
0
0
21
42
6.75
10.86
5.5
4.7
0.13
0.62
e9/l
3.87
13
28
56
268
6.78
10.53
61.4
9.9
5.51
5.71
kpa
1.64
56
263
61
335
8.06
10.44
33.4
8.2
—
—
—
0
0
24
58
5.81
10.17
1.8
2.1
—
—
—
0
0
17
16
13.66
9.97
5.4
4.1
0.65
0.56
index
0.11
17
16
54
262
5.88
9.65
58.6
9.7
5.39
5.42
kpa
0.07
54
257
55
278
5.82
9.15
54.6
10.7
—
—
—
0
0
58
310
6.46
8.91
31.0
4.7
203.64
204.99
u/l
0.03
58
296
34
123
4.48
8.69
4.4
1.6
—
—
—
0
0
55
290
5.42
8.35
26.8
4.4
0.09
0.24
e6/l
0.59
49
208
54
282
5.21
8.27
13.3
4.3
66.89
49.08
ug/l
0.58
54
271
17
26
8.30
7.72
3.6
5.1
21.00
28.50
umol/l
1.06
17
26
37
153
4.06
7.68
8.6
3.1
2.42
2.45
mmol/l
0.58
37
141
56
311
5.25
7.65
59.1
11.3
4.91
4.94
kpa
0.14
56
303
11
7
18.33
7.51
6.2
2.0
—
—
—
0
0
11
7
18.33
7.51
26.0
12.4
7.80
4.53
pmol/l
—
11
7
55
305
4.96
7.43
29.6
4.4
16.20
11.93
e6/l
0.37
49
228
40
180
3.91
7.24
5.3
4.7
2.99
2.24
mg/l
1.62
40
168
19
50
4.86
7.10
33.5
18.1
0.67
0.63
%
0.15
19
50
20
56
4.62
6.93
57.4
17.0
111.85
124.25
g/l
1.51
20
56
19
52
4.66
6.75
33.5
17.5
1.17
1.12
%
0.26
19
52
44
220
3.76
6.63
20.2
4.0
2.56
0.51
e6/l
0.67
36
129
62
418
5.75
6.50
48.4
11.0
—
—
—
0
0
62
423
5.58
6.23
125.6
18.3
1.24
1.24
mmol/l
0.15
62
412
56
339
4.46
6.13
39.6
5.8
14.27
24.35
e6/l
0.60
49
228
55
330
4.29
6.07
89.6
16.4
24.70
24.41
mmol/l
0.37
55
330
62
429
5.38
5.96
122.5
15.2
1.24
1.24
mmol/l
0.04
62
416
23
80
3.81
5.89
23.5
7.0
—
—
—
0
0
37
177
3.35
5.76
2.5
1.6
—
—
—
0
0
13
21
7.36
5.71
4.7
2.2
—
—
—
0
0
25
94
3.60
5.69
64.4
16.6
105.80
105.84
mmol/l
0.02
25
94
14
26
6.47
5.59
2.5
3.4
25.07
33.31
mmol/l
0.53
14
26
13
22
7.01
5.54
5.2
1.6
0.00
0.00
estimate
—
7
5
15
31
5.88
5.53
34.5
6.4
23.53
23.43
mmol/l
0.04
15
31
5
0
+∞
5.27
2.4
0.0
143.60
—
e6/l
—
5
0
18
57
3.92
5.21
4.7
3.1
4.33
3.89
e9/l
0.27
18
52
9
10
10.13
4.95
1.2
1.1
—
—
—
0
0
9
10
10.13
4.95
1.2
1.1
—
—
—
0
0
8
7
12.70
4.92
24.5
3.6
1.06
1.36
mmol/l
—
8
7
10
14
8.14
4.85
1.3
1.1
—
—
—
0
0
10
14
8.14
4.85
20.9
7.7
—
—
—
0
0
14
32
5.21
4.77
12.0
2.3
0.04
0.07
e6/l
0.34
14
32
7
5
15.34
4.68
3.9
6.4
30.00
33.60
pg
—
7
5
7
5
15.34
4.68
1.3
1.2
—
—
—
0
0
13
28
5.47
4.66
1.5
1.2
—
—
—
0
0
10
15
7.59
4.66
2.2
2.6
0.97
1.02
umol/l
—
10
15
9
12
8.43
4.51
20.1
5.5
7.39
7.36
ph
—
9
12
43
248
2.95
4.51
13.4
4.3
33.09
36.21
mmol/mol
2.65
43
236
10
16
7.10
4.48
2.0
1.3
—
—
—
0
0
48
298
3.01
4.32
22.1
3.4
0.00
0.00
estimate
-0.00
17
29
10
17
6.68
4.31
6.1
8.8
37.00
36.98
°c
—
10
17
13
31
4.92
4.29
4.1
4.7
—
—
—
0
0
48
299
2.99
4.28
22.1
3.4
72.29
0.00
estimate
0.48
17
28
48
299
2.99
4.28
22.1
3.4
0.00
0.00
estimate
-0.00
17
29
8
10
8.86
4.18
1.0
1.3
—
—
—
0
0
8
10
8.86
4.18
3.8
2.1
—
—
—
0
0
8
10
8.86
4.18
1.0
1.3
—
—
—
0
0
8
10
8.86
4.18
1.0
1.0
—
—
—
0
0
45
273
2.86
4.18
15.7
3.2
6.17
6.35
ph
0.38
21
109
7
7
10.94
4.11
3.7
3.1
—
—
—
0
0
11
23
5.48
4.07
1.3
1.5
—
—
—
0
0
56
387
3.37
4.02
32.1
4.4
—
—
—
0
0
14
40
4.12
3.89
7.6
5.0
42.66
38.14
%
0.44
14
40
6
5
12.95
3.83
1.2
1.0
—
—
—
0
0
6
5
12.95
3.83
1.2
1.0
—
—
—
0
0
6
5
12.95
3.83
1.2
1.0
—
—
—
0
0
9
16
6.29
3.80
2.0
1.9
—
—
—
0
0
10
21
5.38
3.72
2.3
2.7
13.38
11.50
umol/l
—
10
21
8
13
6.80
3.61
9.1
2.2
1.56
1.55
mmol/l
—
8
13
13
42
3.58
3.59
48.2
19.5
74.18
74.35
%
0.02
13
42
6
6
10.78
3.56
9.0
2.3
3.02
2.28
e9/l
—
6
6
6
6
10.78
3.56
1.7
1.7
75.50
136.00
pmol/l
—
6
6
25
121
2.67
3.49
17.4
2.6
0.00
0.00
estimate
-0.00
15
29
8
14
6.30
3.45
9.0
2.4
65.38
85.07
mg/l
—
8
14
17
67
3.04
3.44
2.6
1.3
—
—
—
0
0
16
61
3.11
3.42
3.5
2.6
3.77
3.31
u/l
—
8
25
13
45
3.33
3.23
3.7
3.6
—
—
—
0
0
22
104
2.64
3.19
4.0
3.2
530.32
568.27
u/l
0.03
22
104
12
37
3.71
3.12
48.5
21.6
11.13
12.09
%
0.51
12
37
6
8
8.07
3.12
1.5
3.4
—
—
—
0
0
6
8
8.07
3.12
1.2
1.1
—
—
—
0
0
6
9
7.17
2.93
1.7
1.2
—
—
—
0
0
6
9
7.17
2.93
26.5
6.3
10.98
8.91
kpa
—
6
9
6
9
7.17
2.93
26.5
6.2
4.73
4.44
kpa
—
6
9
6
9
7.17
2.93
1.5
1.2
23.05
18.51
umol/l
—
6
9
5
6
8.85
2.79
2.0
2.0
2540.20
799.67
u/ml
—
5
6
12
42
3.24
2.72
56.2
20.3
74.17
75.14
%
0.12
12
42
8
20
4.38
2.66
2.0
1.6
—
—
—
0
0
11
37
3.34
2.63
1.4
1.3
352.33
368.82
ug/g
—
6
22
5
7
7.58
2.59
1.0
1.0
—
—
—
0
0
12
47
2.88
2.42
76.2
27.4
1.07
0.92
%
0.91
12
47
12
47
2.88
2.42
76.2
27.5
95.92
94.96
%
0.18
12
47
12
47
2.88
2.42
76.2
27.4
0.76
0.71
%
0.28
12
47
8
24
3.63
2.26
20.6
3.6
—
—
—
0
0
12
49
2.75
2.25
76.2
25.8
23.42
23.88
mmol/l
0.25
12
49
9
31
3.18
2.16
2.8
3.3
—
—
—
0
0
5
10
5.29
2.10
2.0
2.2
—
—
—
0
0
8
27
3.21
2.01
5.0
5.3
3.13
52.59
u/ml
—
8
27
6
16
4.00
1.98
1.5
1.6
—
—
—
0
0
5
11
4.80
1.97
9.2
7.2
—
—
—
0
0
11
47
2.59
1.89
5.7
5.1
—
—
—
0
0
11
47
2.59
1.89
5.5
5.5
—
—
—
0
0
13
61
2.39
1.85
4.2
2.6
4.91
8.11
iu/l
—
7
31
16
83
2.21
1.83
1.9
2.0
103.29
92.27
pmol/l
—
7
38
45
342
1.91
1.73
3.2
1.9
1.53
1.15
g/l
1.34
34
143
25
157
1.93
1.73
17.6
2.4
0.00
0.00
estimate
-0.00
15
26
11
50
2.43
1.67
5.7
5.2
1.67
3.92
e6/l
—
6
36
11
50
2.43
1.67
5.7
5.3
2.83
840.36
e6/l
—
6
36
5
15
3.51
1.55
13.6
4.5
5.28
4.79
kpa
—
5
15
36
265
1.75
1.45
2.7
2.4
—
—
—
0
0
5
17
3.09
1.38
5.2
4.5
28.83
23.13
ug/l
—
5
17
5
17
3.09
1.38
2.4
2.1
112.30
126.06
ng/l
—
5
17
54
456
1.85
1.26
7.0
3.7
2.66
2.31
mu/l
1.34
54
432
10
50
2.17
1.23
6.3
1.5
50.06
49.04
%
—
10
50
10
50
2.17
1.23
6.2
5.0
1098.80
384.56
mg/l
—
10
50
6
26
2.43
1.21
2.2
1.2
—
—
—
0
0
8
39
2.19
1.20
4.5
6.2
3.85
2.31
ug/l
—
8
39
7
34
2.18
1.06
5.1
5.0
—
—
—
0
0
8
48
1.75
0.82
5.1
3.0
1393.19
7.30
mg/mmol
—
8
33
7
42
1.74
0.71
1.3
1.2
—
9.63
—
0
8
69
668
+∞
0.60
140.8
21.8
7.57
7.69
e9/l
0.10
69
624
69
668
+∞
0.60
140.6
21.7
4.20
4.54
e12/l
6.10
69
624
69
668
+∞
0.60
140.7
21.9
290.07
290.49
e9/l
0.01
69
627
6
40
1.55
0.53
1.2
1.3
—
—
—
0
0
6
40
1.55
0.53
1.0
1.3
—
—
—
0
0
47
421
1.37
0.52
4.3
3.7
14.84
14.59
pmol/l
0.19
47
401
7
45
1.62
0.51
2.6
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
2.1
—
—
—
0
0
6
41
1.51
0.37
1.2
1.3
—
—
—
0
0
14
175
0.75
0.36
1.3
1.3
—
—
—
0
0
13
101
1.35
0.35
1.0
1.0
—
—
—
0
0
6
45
1.36
0.35
1.7
2.4
—
—
—
0
0
21
181
1.23
0.27
5.5
2.0
—
—
—
0
0
5
40
1.27
0.23
1.2
1.7
2.42
2.46
mmol/l
—
5
25
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
52
1.17
0.19
1.2
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
0.55
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
6.00
—
0
8
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
113.00
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.6
—
7.20
—
0
5
0
5
0.00
-0.00
0.0
12.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
21.8
—
10.70
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint K11_HYPOPLASIA_ENAMEL_PRENATAL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_HYPOPLASIA_ENAMEL_PRENATAL.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: K11_HYPOPLASIA_ENAMEL_PRENATAL – Hypoplasia of dental enamel, prenatal

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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