extrinsic allergic alveolitis: An inflammatory interstitial lung disease caused by hypersensitivity reaction to inhalation or ingestion of antigens. The antigens are usually related to the patient's occupation. It can present as an acute illness with flu-like symptoms, subacute with repeated episodes of pneumonia, or chronic with dyspnea and productive cough. The majority of patients recover following the cessation of the exposure to the antigen that causes the disease. Chronic exposure may eventually progress to interstitial lung fibrosis.
Hypersensitivity pneumonitis due to organic dust
DOID EFO Endpoint Browser PheWeb
J10_HYPERSPNEUMONI
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
664 |
4. Check minimum number of eventsNone |
664 |
5. Include endpointsNone |
664 |
6. Filter based on genotype QC (FinnGen only) |
589 |
Control definitions (FinnGen only)
- Control exclude
- J10_EXTERLUNG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J60-J70
- Name in latin
- Pneumonitis/alveolitis hypersensitiva e pulvere organico
Similar endpoints
↥List of similar endpoints to
Hypersensitivity pneumonitis due to organic dust
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5824 | 2873 | 2887 |
| Only index persons | 4602 | 2341 | 2261 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.09 | 0.09 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 52.93 | 53.15 | 52.37 |
| Only index persons | 49.96 | 50.96 | 48.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 589 | 304 | 285 |
| Unadjusted period prevalence (%) | 0.12 | 0.11 | 0.13 |
| Median age at first event (years) | 50.13 | 47.68 | 52.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 600
- Matched controls
- 6000
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J67.0
ICD-10 Finland
Farmer lung
+∞
224.5
201
*
J67.9
ICD-10 Finland
Hypersensitivity pneumonitis due to unspecified organic dust
+∞
205.3
185
*
4950A
ICD-9 Finland
Extrinsic allergic alveolitis, Farmers' lung
+∞
125.5
116
*
TGC00
NOMESCO Finland
Bronchial lavation
14.3
101.9
99
82
4959X
ICD-9 Finland
Extrinsic allergic alveolitis, Unspecified allergic alveolitis and pneumonitis
+∞
94.3
88
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
8.6
77.1
109
151
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
12.9
63.7
64
55
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
12.0
60.9
64
59
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.7
58.6
126
267
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
9.8
54.1
66
75
H02AB06
ATC
prednisolone; systemic
3.8
51.6
410
2185
J67.8
ICD-10 Finland
Hypersensitivity pneumonitis due to other organic dusts
+∞
48.6
46
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.1
41.7
135
393
J45.1
ICD-10 Finland
Nonallergic asthma
4.6
35.7
93
228
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.1
33.0
75
164
J45.9
ICD-10 Finland
Asthma, unspecified
3.0
31.8
183
758
XG410
NOMESCO Finland
Flow-volume spirometry
5.8
29.9
57
106
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.9
29.6
180
765
51610
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of other dust
+∞
28.4
27
*
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.7
28.2
46
73
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.8
26.6
92
276
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
26.0
223
1119
R06.0
ICD-10 Finland
Dyspnoea
2.5
24.2
230
1203
R03BA01
ATC
beclometasone; inhalant
3.0
24.1
127
493
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
8.5
20.7
27
33
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
33.9
20.3
26
8
R03AC02
ATC
salbutamol; inhalant
2.2
19.5
374
2557
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.4
19.4
77
251
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
6.8
18.9
30
46
R03AK08
ATC
formoterol and beclometasone; inhalant
4.2
18.3
50
126
J01FA06
ATC
roxithromycin; oral
2.1
17.9
278
1734
4958X
ICD-9 Finland
Extrinsic allergic alveolitis, Other specified allergic alveolitis and pneumonitis
+∞
17.8
17
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
13.1
17.3
30
24
GD1AD
NOMESCO Finland
Thorax CT examination
3.3
16.9
68
223
L04AA06
ATC
mycophenolic acid; systemic
6.6
15.9
26
41
L04AX01
ATC
azathioprine; systemic
4.2
14.8
41
104
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
14.7
14.6
24
17
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.4
14.6
115
538
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.8
14.5
46
129
1240
FHL
Bronchoscopy
10.4
14.1
27
27
J67.1
ICD-10 Finland
Bagassosis
+∞
13.6
13
*
J67.2
ICD-10 Finland
Bird fancier lung
+∞
13.6
13
*
R03BB04
ATC
tiotropium bromide; inhalant
2.6
13.5
87
369
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
16.7
13.5
21
13
R50.9
ICD-10 Finland
Fever, unspecified
2.3
12.9
115
565
R03AC12
ATC
salmeterol; inhalant
3.4
12.3
46
144
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
12.3
157
888
A41.9
ICD-10 Finland
Sepsis, unspecified
3.8
12.1
37
101
J47
ICD-10 Finland
Bronchiectasis
5.0
12.0
26
54
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
11.9
321
2310
J01MA12
ATC
levofloxacin; systemic
2.1
11.9
132
707
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
11.9
74
309
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.9
11.8
57
208
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
12.9
11.7
20
16
J66.8
ICD-10 Finland
Airway disease due to other specific organic dusts
+∞
11.5
11
*
J45.8
ICD-10 Finland
Mixed asthma
4.2
11.3
30
74
R03BA02
ATC
budesonide; inhalant
2.1
11.2
128
693
51620
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of fumes
+∞
10.4
10
*
J01MA14
ATC
moxifloxacin; systemic
2.4
9.8
71
317
R03AC03
ATC
terbutaline; inhalant
2.2
9.6
93
471
GX1D5
NOMESCO Finland
Flow volume spirometry
22.1
9.4
13
6
R06.2
ICD-10 Finland
Wheezing
3.3
9.3
36
115
4931A
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA SINE EXACERBATIONE]
10.3
9.1
17
17
J84.0
ICD-10 Finland
Alveolar and parietoalveolar conditions
37.3
9.0
11
*
Z94.2
ICD-10 Finland
Lung transplant status
24.4
8.9
12
5
4779A
ICD-9 Finland
Allergic rhinitis, Cause unspecified
8.8
8.8
18
21
J67.7
ICD-10 Finland
Air-conditioner and humidifier lung
+∞
8.3
8
*
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
11.0
8.3
15
14
R04.2
ICD-10 Finland
Haemoptysis
3.3
8.2
30
93
R05
ICD-10 Finland
Cough
1.8
8.1
134
814
4900A
ICD-9 Finland
Bronchitis, not specified as acute or chronic[BRONCHITIS NUD]
22.4
8.0
11
5
R03AK07
ATC
formoterol and budesonide; inhalant
1.8
7.9
128
772
7860A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Dyspnoea and respiratory abnormalities[DYSPNOEA]
8.6
7.9
16
19
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
7.8
215
1506
R03DA04
ATC
theophylline; systemic, rectal
2.6
7.7
43
170
GDG10
NOMESCO Finland
Bilateral transplantation of lung
25.4
7.6
10
*
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
4.2
7.6
20
49
XG474
NOMESCO Finland
Exhalation nntrogen oxide
3.4
7.5
27
83
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
8.5
7.4
15
18
J67
ICD-10 Finland
Hypersensitivity pneumonitis due to organic dust
+∞
7.3
7
*
4610A
ICD-9 Finland
Acute sinusitis, Maxillary
5.9
7.3
19
33
J96.1
ICD-10 Finland
Chronic respiratory failure
3.8
7.1
21
56
GX1K5
NOMESCO Finland
Diffusion capacity
12.2
7.1
12
10
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
7.1
123
756
R03BA08
ATC
ciclesonide; inhalant
2.2
7.0
59
282
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
6.8
110
661
GDA10
NOMESCO Finland
Biopsy of lung
16.9
6.8
10
6
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
7.3
6.7
15
21
R99
ICPC
Respiratory disease other
3.9
6.6
19
50
J01AA02
ATC
doxycycline; systemic
1.7
6.6
458
3952
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
70.6
6.4
7
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
6.3
155
1045
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
7.1
6.2
14
20
L04AD02
ATC
tacrolimus; systemic
7.8
6.1
13
17
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
103
218
5.50
47.51
3.2
2.8
—
—
—
0
0
55
61
9.83
45.80
2.3
1.8
—
—
—
0
0
115
346
3.87
33.48
1.8
1.3
127.13
210.07
u/ml
0.64
103
315
38
42
9.59
31.55
1.5
1.2
0.14
1.16
u/ml
0.57
22
23
58
134
4.68
23.71
2.3
1.5
—
—
—
0
0
60
156
4.16
21.07
2.3
1.8
—
—
—
0
0
147
667
2.59
20.43
8.8
8.2
0.97
0.94
mmol/l
0.03
121
559
57
150
4.09
19.68
2.4
1.8
—
—
—
0
0
49
116
4.51
19.40
2.4
1.5
—
—
—
0
0
146
679
2.52
19.15
8.9
8.0
5.01
5.13
kpa
0.91
141
657
51
138
3.95
16.92
2.5
1.5
—
—
—
0
0
42
102
4.35
16.08
1.4
1.2
—
—
—
0
0
42
102
4.35
16.08
1.4
1.2
700.00
163.33
titre
—
6
6
39
98
4.19
14.28
2.6
2.0
—
—
—
0
0
32
71
4.70
13.69
3.0
1.6
—
—
—
0
0
41
115
3.75
12.92
1.9
1.6
—
—
—
0
0
24
23
10.82
12.85
2.5
1.5
—
—
—
0
0
36
96
3.93
12.18
1.9
1.6
—
—
—
0
0
31
75
4.30
11.92
2.8
1.6
—
—
—
0
0
96
455
2.32
11.68
4.7
3.0
11.59
10.58
g/l
0.64
90
421
59
221
2.85
11.65
1.9
1.7
11.04
7.62
iu/ml
0.29
16
61
29
68
4.43
11.60
1.2
1.1
—
—
—
0
0
257
1754
1.81
11.14
3.9
3.4
1079.07
1379.74
ng/l
0.83
233
1507
87
422
2.24
9.97
2.0
1.5
—
—
—
0
0
37
120
3.22
9.37
19.6
7.4
268.29
194.71
iu/ml
0.24
14
17
21
29
7.46
9.29
2.0
2.1
—
—
—
0
0
29
81
3.71
9.21
1.2
1.2
—
—
—
0
0
41
145
2.96
8.98
1.5
1.2
4.14
6.27
u/ml
—
5
27
383
3045
1.71
8.90
14.9
10.1
4.39
4.17
e9/l
1.22
361
2666
36
120
3.13
8.73
1.4
1.2
6.40
1.02
u/ml
—
5
8
67
310
2.31
8.56
7.3
3.7
2.01
1.80
mmol/l
0.16
53
241
155
978
1.79
8.30
1.5
1.3
29.65
36.35
iu/ml
0.36
48
323
458
3888
1.75
7.76
7.5
4.5
13.91
12.57
mm/h
1.04
438
3614
23
62
3.82
7.69
1.7
2.3
—
—
—
0
0
153
984
1.74
7.60
2.8
2.0
—
—
—
0
0
40
154
2.71
7.53
1.7
1.5
—
—
—
0
0
14
15
9.53
7.31
1.4
1.3
—
—
—
0
0
18
31
5.95
6.96
2.3
2.2
173.39
172.31
e6/l
0.01
18
26
182
1258
1.64
6.81
5.6
4.1
1.02
1.02
kg/l
1.43
129
839
21
59
3.65
6.64
1.7
2.4
—
—
—
0
0
217
1575
1.59
6.61
5.5
4.1
0.00
0.01
estimate
0.96
71
535
138
904
1.68
6.29
1.5
1.3
10.50
12.94
u/ml
0.17
62
352
178
1253
1.60
6.08
3.6
2.7
5.17
5.59
e6/l
0.17
167
1149
20
58
3.53
6.06
1.3
1.4
—
—
—
0
0
27
95
2.93
6.01
1.5
1.4
141.50
175.46
au/ml
—
8
25
10
9
11.27
5.81
4.4
1.8
—
—
—
0
0
82
476
1.84
5.66
3.0
2.4
0.18
0.59
e6/l
1.27
77
457
17
37
4.70
5.52
2.4
1.5
—
—
—
0
0
348
2887
1.49
5.32
9.5
6.9
12.23
11.56
umol/l
0.20
335
2761
269
2120
1.49
5.32
5.3
3.9
0.01
0.03
estimate
0.24
68
477
23
81
2.91
5.14
6.4
5.2
12.71
11.49
mg/l
0.50
16
76
85
514
1.76
5.12
2.6
2.1
316.85
384.35
nmol/l
3.33
80
481
13
23
5.75
5.09
5.2
5.4
—
—
—
0
0
114
752
1.64
4.99
2.7
1.8
—
—
—
0
0
337
2802
1.46
4.93
10.6
7.4
1.21
1.21
mmol/l
0.45
303
2434
26
101
2.65
4.86
1.4
1.2
291.82
284.38
u/ml
0.04
17
55
15
42
3.64
4.79
2.3
1.6
—
—
—
0
0
223
1721
1.47
4.77
3.1
2.5
61.05
62.90
u/l
0.12
209
1615
14
31
4.60
4.58
2.6
1.5
—
—
—
0
0
106
701
1.62
4.57
2.8
1.9
—
—
—
0
0
14
33
4.32
4.34
2.6
1.5
—
—
—
0
0
310
2579
1.42
4.28
19.6
15.4
1.32
1.26
inr
0.99
267
2159
266
2156
1.42
4.25
4.3
4.0
30.44
68.78
ng/l
0.85
196
1602
26
110
2.43
4.12
4.3
4.1
14.88
31.96
mg/l
3.62
20
77
19
69
2.81
4.05
4.7
4.2
—
—
—
0
0
226
1795
1.42
3.98
4.7
3.4
120.92
89.14
e6/l
0.15
191
1373
303
2533
1.40
3.95
9.9
6.6
1.20
1.21
mmol/l
1.15
293
2335
370
3200
1.41
3.95
8.6
5.1
6.74
6.69
mmol/l
0.12
359
3052
12
28
4.35
3.83
3.9
1.8
28.73
53.30
ug/l
2.22
12
28
14
38
3.75
3.81
1.3
1.3
—
—
—
0
0
144
1060
1.47
3.80
1.9
1.5
2.56
2.49
g/l
0.15
105
651
69
431
1.68
3.72
3.0
2.8
66.88
63.86
ml/min/173m2
0.28
34
189
20
79
2.58
3.66
1.3
1.1
1.39
0.63
u/ml
—
8
39
215
1723
1.39
3.50
3.2
2.1
210.65
208.35
u/l
0.02
201
1639
10
22
4.60
3.44
1.5
2.5
—
—
—
0
0
52
307
1.76
3.43
1.6
1.4
—
—
—
0
0
8
14
5.77
3.35
1.0
1.0
—
—
—
0
0
151
1149
1.42
3.30
1.8
1.7
449.74
22503069.79
pmol/l
0.94
137
951
15
54
2.82
3.27
1.3
1.9
—
—
—
0
0
15
54
2.82
3.27
1.3
1.9
—
—
—
0
0
15
54
2.82
3.27
1.3
1.9
—
—
—
0
0
447
4054
1.40
3.22
12.4
8.6
77.53
79.13
u/l
0.45
434
3843
95
665
1.51
3.18
4.3
4.6
245.73
249.88
u/l
0.12
88
635
28
139
2.06
3.11
1.2
1.4
—
—
—
0
0
16
63
2.58
2.98
1.1
1.2
—
—
—
0
0
9
22
4.14
2.89
1.6
2.5
—
—
—
0
0
9
22
4.14
2.89
1.6
2.5
—
—
—
0
0
242
2023
1.33
2.88
5.6
4.0
225.35
107.71
e6/l
0.69
197
1431
26
131
2.03
2.79
3.0
2.2
139.25
128.08
g/l
0.95
20
103
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
30
164
1.87
2.58
4.2
3.3
0.26
0.35
iu/ml
1.35
20
90
24
122
2.01
2.54
2.6
3.2
33.35
35.66
umol/l
0.18
19
110
10
31
3.26
2.52
1.5
2.2
—
—
—
0
0
10
31
3.26
2.52
1.5
2.2
—
—
—
0
0
10
31
3.26
2.52
1.5
2.2
—
—
—
0
0
10
31
3.26
2.52
1.5
2.2
—
—
—
0
0
61
413
1.53
2.41
2.1
1.7
—
—
—
0
0
30
171
1.79
2.29
1.2
1.6
0.11
0.10
iu/ml
—
8
33
35
209
1.72
2.29
2.3
2.1
—
—
—
0
0
68
477
1.48
2.28
2.8
3.4
66.86
66.62
g/l
0.07
63
445
17
79
2.19
2.26
1.4
1.3
1.67
2.88
u/ml
—
9
25
14
60
2.37
2.23
1.1
1.1
92.93
98.33
%
0.27
14
55
318
2834
1.26
2.10
5.6
4.0
0.00
2.76
estimate
0.50
77
589
26
146
1.82
2.10
1.2
1.8
—
—
—
0
0
5
10
5.03
2.07
4.0
8.1
5.02
4.91
kpa
—
5
10
5
10
5.03
2.07
4.0
8.1
6.68
6.14
kpa
—
5
10
272
2384
1.26
2.06
3.3
2.5
77.39
77.28
nmol/l
0.02
259
2133
315
2809
1.26
2.05
5.5
4.0
0.00
0.00
estimate
-0.00
76
569
41
264
1.59
2.04
1.8
2.1
1.70
1.46
g/l
0.65
34
241
172
1429
1.29
2.02
4.8
2.9
351.47
348.07
umol/l
0.16
158
1256
193
2251
0.79
1.96
2.1
2.0
1.48
1.35
mmol/l
1.42
172
1883
8
27
2.99
1.94
1.6
2.1
96.38
99.37
%
—
8
27
150
1242
1.28
1.80
2.1
1.7
1.08
1.35
mg/l
0.78
121
983
318
2866
1.23
1.79
5.5
4.0
0.00
0.57
estimate
0.52
74
546
76
571
1.38
1.79
4.4
3.5
1.44
1.90
mmol/l
0.42
70
492
71
528
1.39
1.78
12.9
7.8
1.37
1.35
mmol/l
0.07
71
518
180
1529
1.25
1.74
4.7
3.4
0.00
0.06
estimate
0.60
63
452
17
89
1.94
1.71
1.2
1.4
—
—
—
0
0
217
1887
1.23
1.69
5.0
3.5
2.35
2.36
mmol/l
0.69
207
1714
6
19
3.18
1.66
1.0
3.1
212.50
204.21
u/l
—
6
19
277
2476
1.22
1.64
3.8
2.9
—
—
estimate
—
0
0
171
1453
1.25
1.64
2.6
2.2
3.26
2.95
mg/l
1.15
161
1260
22
362
0.59
1.63
2.1
1.8
3.25
3.53
mmol/l
0.76
17
266
15
78
1.95
1.55
1.1
1.1
—
—
—
0
0
28
178
1.60
1.51
3.0
4.0
2.03
2.53
ratio
0.19
15
106
5
16
3.14
1.44
1.2
1.2
—
—
—
0
0
373
3462
1.20
1.42
6.5
4.8
51.50
1647.79
e6/l
1.26
14
58
12
60
2.02
1.39
1.3
1.3
—
—
—
0
0
6
23
2.62
1.37
1.2
1.1
—
—
—
0
0
15
82
1.85
1.36
1.3
1.2
6.63
4.03
u/ml
—
8
36
178
1548
1.21
1.35
4.6
3.2
0.25
0.43
e6/l
2.09
149
1132
27
177
1.55
1.31
1.7
1.6
—
—
—
0
0
29
196
1.50
1.24
3.0
4.2
39.10
78.35
mg/l
0.67
21
167
10
49
2.06
1.22
1.1
1.1
—
84.29
—
0
7
8
37
2.18
1.22
1.1
1.8
—
—
—
0
0
6
26
2.32
1.19
2.5
2.7
526.83
768.04
u/ml
—
6
26
6
26
2.32
1.19
1.0
1.0
1589.67
1483.96
miu/ml
—
6
26
5
20
2.51
1.15
2.4
1.2
9.93
8.76
ug/l
—
5
20
7
30
2.35
1.12
8.9
3.4
1.00
1.20
%
—
7
30
267
2440
1.17
1.12
7.9
5.1
34.59
35.68
g/l
2.28
256
2297
27
185
1.48
1.10
1.5
1.3
—
—
—
0
0
28
196
1.45
1.04
3.0
4.2
37.83
57.76
mg/l
0.46
20
168
0
29
0.00
0.98
0.0
1.2
—
—
—
0
0
111
954
1.20
0.95
1.9
1.7
1173.93
1177.42
nmol/l
0.01
97
732
27
192
1.43
0.94
2.3
1.9
—
—
—
0
0
9
52
1.74
0.92
1.9
2.9
4.72
6.23
nmol/l
—
9
52
18
119
1.53
0.89
2.1
1.6
—
—
—
0
0
23
161
1.45
0.88
1.3
1.3
—
—
—
0
0
6
30
2.01
0.87
1.2
1.3
17.50
16.84
u/l
—
6
25
148
1316
1.17
0.86
3.4
2.6
—
—
—
0
0
53
651
0.80
0.84
5.7
5.1
31.43
32.17
%
0.19
40
424
6
32
1.88
0.82
1.2
1.3
208.33
86.59
u/l
—
6
27
6
32
1.88
0.82
1.0
1.2
—
—
—
0
0
8
48
1.68
0.79
5.0
1.9
14.16
13.13
%
—
8
48
21
149
1.42
0.76
1.3
1.5
22163.21
14335.85
e6/l
0.27
14
112
9
53
1.71
0.75
1.3
1.3
52193.00
225796.64
e6/l
—
9
39
5
24
2.09
0.74
1.2
1.1
—
—
—
0
0
45
362
1.26
0.74
1.9
1.7
—
—
—
0
0
9
143
0.62
0.70
1.7
1.3
—
—
—
0
0
518
5057
1.18
0.68
27.2
16.8
21.84
24.35
mg/l
1.26
472
4213
71
613
1.18
0.62
8.2
7.4
—
—
—
0
0
5
30
1.67
0.61
1.2
1.1
—
—
—
0
0
8
51
1.58
0.60
1.4
1.1
—
—
—
0
0
206
1918
1.11
0.59
3.9
3.4
7.64
7.68
mmol/l
0.04
186
1616
530
5196
1.17
0.59
29.9
20.2
139.64
139.68
mmol/l
0.14
524
5110
45
377
1.21
0.55
3.4
3.0
131.00
128.98
g/l
0.23
45
369
474
4854
0.89
0.55
7.0
6.7
40.33
39.66
mmol/mol
1.03
449
4555
410
3966
1.11
0.54
4.6
4.3
14.94
14.88
pmol/l
0.17
390
3611
480
4910
0.89
0.53
22.9
16.3
77.55
79.46
ml/min/173m2
1.10
455
4582
15
108
1.40
0.53
4.1
3.1
7.43
8.90
pmol/l
0.37
15
108
530
5204
1.16
0.53
30.0
20.4
4.03
3.99
mmol/l
3.27
524
5108
18
236
0.76
0.51
1.9
1.5
0.20
0.34
mg/l
—
8
109
259
2459
1.09
0.49
3.5
3.0
146.30
136.95
ug/l
0.26
248
2277
63
553
1.16
0.47
3.6
3.4
—
—
—
0
0
22
173
1.28
0.47
1.2
1.4
—
—
—
0
0
7
49
1.43
0.46
1.4
1.0
—
—
—
0
0
159
1483
1.10
0.44
5.2
4.6
21.39
21.68
%
0.11
88
697
19
241
0.78
0.44
1.1
1.0
—
—
—
0
0
501
4915
1.12
0.44
5.7
5.3
5.87
6.00
mmol/l
2.25
476
4513
13
95
1.38
0.44
1.5
1.6
—
—
—
0
0
17
131
1.31
0.42
1.6
1.3
717.53
478.97
mg/l
0.32
17
124
0
15
0.00
0.41
0.0
1.1
—
28.63
—
0
10
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
8
59
1.36
0.41
1.1
1.3
67.63
45.76
u/l
—
8
52
0
17
0.00
0.40
0.0
1.2
—
315.18
—
0
11
194
1834
1.09
0.40
5.9
5.5
2.81
2.59
ug/l
0.12
182
1659
10
71
1.42
0.39
1.2
1.3
0.61
27.13
nmol/l
—
10
64
5
35
1.43
0.39
3.0
1.4
70.00
77.80
umol/l
—
5
35
36
419
0.85
0.39
1.8
1.8
—
—
—
0
0
234
2440
0.93
0.34
2.2
2.2
92.96
95.26
pmol/l
0.37
135
1300
6
44
1.37
0.34
1.5
1.1
—
—
—
0
0
6
44
1.37
0.34
1.3
1.1
—
—
—
0
0
45
508
0.88
0.34
3.8
2.3
30.50
35.37
u/l
0.55
40
426
6
46
1.31
0.33
1.5
1.1
—
—
—
0
0
6
46
1.31
0.33
1.5
1.1
—
—
—
0
0
11
143
0.76
0.32
6.3
2.9
2.37
2.21
index
—
6
81
7
52
1.35
0.31
2.4
1.2
108.71
100.19
pmol/l
—
7
52
7
54
1.30
0.30
1.4
1.1
1.17
1.65
nmol/l
—
7
48
7
54
1.30
0.30
1.4
1.1
—
—
—
0
0
355
3459
1.06
0.30
4.0
3.3
47.71
50.57
u/l
0.36
338
3277
103
962
1.09
0.29
3.8
2.9
0.77
1.13
e6/l
1.21
66
509
8
62
1.29
0.28
2.0
3.0
—
—
—
0
0
194
1866
1.06
0.25
4.5
4.2
9.66
9.46
mg/mmol
0.02
137
1174
9
77
1.17
0.24
10.7
5.9
374.78
356.97
umol/l
—
9
70
5
38
1.32
0.23
1.6
1.2
—
—
—
0
0
118
1121
1.07
0.23
3.2
3.0
2.46
2.45
mmol/l
0.39
110
1008
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
43.50
—
0
10
69
645
1.08
0.21
2.5
2.6
8.41
8.59
umol/l
0.03
60
571
15
127
1.19
0.19
1.5
1.6
—
—
—
0
0
87
823
1.07
0.19
1.5
1.5
—
—
—
0
0
6
51
1.18
0.19
1.3
1.1
—
—
—
0
0
42
456
0.92
0.19
1.9
1.9
—
—
—
0
0
6
53
1.13
0.18
1.3
1.1
—
—
—
0
0
6
53
1.13
0.18
2.0
2.9
194.33
933.85
mg
—
6
53
14
162
0.86
0.16
1.4
1.1
0.87
0.92
g/l
0.40
14
162
6
76
0.79
0.15
1.0
1.0
—
—
—
0
0
475
4704
1.05
0.15
5.6
5.4
1.95
1.95
mu/l
0.00
449
4322
113
1091
1.04
0.13
3.3
3.2
0.83
0.78
ug/l
0.15
84
707
93
894
1.05
0.13
4.3
3.1
1.97
1.95
e6/l
0.02
56
440
19
171
1.11
0.12
1.4
1.1
—
—
—
0
0
19
171
1.11
0.12
1.4
1.1
—
—
—
0
0
484
4808
1.03
0.10
4.7
4.4
1.34
1.29
mmol/l
0.75
461
4421
12
106
1.13
0.10
2.8
1.2
148.42
37.85
u/l
0.44
12
93
19
174
1.09
0.09
1.9
1.7
—
—
—
0
0
5
47
1.06
0.09
1.0
1.1
—
—
—
0
0
14
155
0.90
0.09
1.4
1.1
1.41
1.55
g/l
1.21
14
155
34
321
1.06
0.09
1.1
1.2
47.58
141.45
u/ml
2.61
16
127
6
54
1.11
0.09
1.2
1.1
—
—
—
0
0
7
64
1.09
0.08
1.0
1.2
344.86
338.67
pmol/l
—
7
56
506
5036
1.03
0.07
5.5
5.3
4.59
4.60
mmol/l
0.07
486
4694
167
1692
0.98
0.05
1.8
1.7
17.54
20.27
nmol/l
1.68
157
1423
117
1190
0.98
0.05
1.3
1.3
0.69
1.61
u/ml
1.52
39
322
12
130
0.92
0.04
1.8
1.5
—
—
—
0
0
299
3011
0.99
0.04
3.0
2.9
—
—
—
0
0
112
1104
1.02
0.04
5.0
4.0
1128.09
317.70
ng/l
0.76
93
874
535
5337
1.02
0.03
16.8
12.6
26.20
26.21
u/l
0.01
525
5198
25
260
0.96
0.03
1.5
1.3
—
—
—
0
0
22
211
1.04
0.03
2.3
1.8
—
—
—
0
0
25
259
0.96
0.02
4.2
3.1
36.52
59.12
u/ml
0.60
25
249
17
178
0.95
0.02
9.1
3.1
1.72
1.57
mg/l
0.22
17
161
17
176
0.96
0.00
1.2
1.3
—
—
—
0
0
18
185
0.97
0.00
2.1
1.8
40.17
41.70
nmol/l
0.12
18
175
10
103
0.97
0.00
1.6
1.3
—
—
—
0
0
10
103
0.97
0.00
1.6
1.3
—
—
—
0
0
62
615
1.01
0.00
2.0
1.8
1.57
1.51
%
0.26
56
543
502
5016
1.00
0.00
5.4
5.2
1.42
1.46
mmol/l
1.37
479
4638
61
608
1.00
0.00
3.0
4.6
18.86
31.54
ug/l
0.32
55
510
64
641
1.00
0.00
1.5
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
52.40
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
82
0.98
-0.00
1.3
1.5
—
—
—
0
0
512
5120
1.00
-0.00
6.0
6.0
2.72
2.68
mmol/l
0.52
489
4750
7
75
0.93
-0.00
1.3
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
5.83
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
7
76
0.92
-0.00
1.3
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
78
0.90
-0.00
1.3
1.6
—
—
—
0
0
7
78
0.90
-0.00
1.3
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
1.18
—
0
9
7
75
0.93
-0.00
1.3
1.6
—
—
—
0
0
6
59
1.02
-0.00
1.0
1.1
—
—
—
0
0
5
52
0.96
-0.00
2.4
3.5
23.96
50.47
u/ml
—
5
52
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
11
110
1.00
-0.00
1.5
3.8
617.20
429.30
u/ml
0.14
11
103
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
77
0.91
-0.00
1.3
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint J10_HYPERSPNEUMONI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_HYPERSPNEUMONI | 1.979 [1.7, 2.31] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 288 out of 1173 females with J10_HYPERSPNEUMONI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_HYPERSPNEUMONI | 1.516 [1.31, 1.76] | < 0.001 |
| Birth year | 0.985 [0.97, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 1282 males with J10_HYPERSPNEUMONI died.
Mortality risk
Mortality risk for people of age
years, who have J10_HYPERSPNEUMONI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.223% | 0.299% |
| 5 | 1.17% | 1.727% |
| 10 | 2.856% | 4.114% |
| 15 | 5.534% | 7.983% |
| 20 | 9.455% | 13.086% |
Relationships between endpoints
↥Index endpoint: J10_HYPERSPNEUMONI – Hypersensitivity pneumonitis due to organic dust
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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