Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours

J10_CHEMGASRESP

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 J68
  • Hospital discharge: ICD-9 506
  • Hospital discharge: ICD-8 516[1-2]
  • Cause of death: ICD-10 J68
  • Cause of death: ICD-9 506
  • Cause of death: ICD-8 516[1-2]

2 out of 7 registries used, show all original rules.

344

4. Check minimum number of events

None

344

5. Include endpoints

None

344

6. Filter based on genotype QC (FinnGen only)

315

Control definitions (FinnGen only)

Control exclude
J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J60-J70
Name in latin
Morbositates respiratoriae ex inhalatione chemicalium, gasorum, fumorum et vaporum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3900 1869 1984
Only index persons 2958 1403 1555
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.06
Only index persons 0.06 0.05 0.06
Median age at first event (years)
Whole population 46.70 48.34 45.06
Only index persons 43.67 45.69 41.84

-FinnGen-

Key figures

All Female Male
Number of individuals 315 125 190
Unadjusted period prevalence (%) 0.07 0.04 0.09
Median age at first event (years) 45.52 45.31 45.65

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
327
Matched controls
3270
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
51610
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of other dust
+∞
96.8
88
*
J68.0
ICD-10 Finland
Bronchitis and pneumonitis due to chemicals, gases, fumes and vapours
+∞
71.5
66
*
J68.3
ICD-10 Finland
Other acute and subacute respiratory conditions due to chemicals, gases, fumes and vapours
+∞
61.4
57
*
J68.9
ICD-10 Finland
Unspecified respiratory condition due to chemicals, gases, fumes and vapours
+∞
52.5
49
*
51620
ICD-8 Finland
Other pneumoconiosis and related diseases, Due to inhalation of fumes
+∞
32.9
31
*
4950A
ICD-9 Finland
Extrinsic allergic alveolitis, Farmers' lung
+∞
22.1
21
*
J67.0
ICD-10 Finland
Farmer lung
+∞
20.0
19
*
J68.2
ICD-10 Finland
Upper respiratory inflammation due to chemicals, gases, fumes and vapours, not elsewhere classified
+∞
16.8
16
*
J68.4
ICD-10 Finland
Chronic respiratory conditions due to chemicals, gases, fumes and vapours
+∞
15.7
15
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.9
14.6
87
367
R03AC02
ATC
salbutamol; inhalant
2.4
12.9
204
1339
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.5
12.8
47
148
R06.0
ICD-10 Finland
Dyspnoea
2.3
11.4
116
623
H02AB06
ATC
prednisolone; systemic
2.1
10.0
175
1153
5062A
ICD-9 Finland
Respiratory conditions due to chemical fumes and vapours, Upper respiratory inflammation due to fumes and vapours
+∞
9.4
9
*
J68.1
ICD-10 Finland
Pulmonary oedema due to chemicals, gases, fumes and vapours
+∞
8.4
8
*
R03BA02
ATC
budesonide; inhalant
2.3
8.2
70
344
R03AK07
ATC
formoterol and budesonide; inhalant
2.2
7.5
74
385
J45.1
ICD-10 Finland
Nonallergic asthma
3.1
7.5
33
116
5060A
ICD-9 Finland
Respiratory conditions due to chemical fumes and vapours, Bronchitis and pneumonitis due to fumes and vapours
+∞
7.3
7
*
Y0499
ICD-8 Finland
Investigation of respiratory system
11.3
6.8
12
11
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.1
6.7
75
408
T58
ICD-10 Finland
Toxic effect of carbon monoxide
23.1
6.7
9
*
X47
ICD-10 Finland
Accidental poisoning by and exposure to carbon monoxide and other gases and vapours
71.2
6.4
7
*
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
6.4
125
822
J68.8
ICD-10 Finland
Other respiratory conditions due to chemicals, gases, fumes and vapours
+∞
6.3
6
*
N02AX02
ATC
tramadol; systemic, rectal
1.8
6.1
148
1033

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
101
635
1.85
5.86
1.8
1.7
1.32
1.26
mg/l
0.10
77
507
60
322
2.06
5.51
6.7
9.4
95.48
95.22
%
0.16
55
314
18
53
3.54
5.39
3.9
3.6
4.85
4.96
kpa
0.25
18
53
18
53
3.54
5.39
3.9
3.6
8.53
8.40
kpa
0.11
18
53
18
53
3.54
5.39
3.9
3.6
2.38
2.47
mmol/l
0.07
13
32
15
42
3.70
4.82
2.1
2.6
—
—
—
0
0
185
1440
1.66
4.74
6.3
6.4
1.83
1.83
e9/l
0.02
170
1292
14
31
4.67
4.61
1.5
1.9
90.22
90.05
%
0.04
14
31
61
351
1.91
4.57
7.1
8.9
7.43
7.42
ph
0.42
34
220
11
19
5.95
4.48
4.2
2.0
13.21
13.30
%
0.09
11
19
185
1456
1.62
4.41
6.7
6.6
0.20
0.20
e9/l
0.02
169
1293
181
1418
1.62
4.39
6.4
6.4
0.04
0.04
e9/l
0.44
165
1242
38
188
2.16
4.30
4.3
6.3
—
—
—
0
0
196
1571
1.62
4.28
8.7
10.3
4.33
4.18
e9/l
0.41
173
1394
204
1664
1.60
4.03
6.1
5.6
6.72
6.75
mmol/l
0.06
193
1589
21
82
2.67
3.97
4.9
3.3
7.42
7.41
ph
0.20
21
82
178
1412
1.57
3.93
6.5
6.3
0.63
0.60
e9/l
1.07
163
1234
15
49
3.16
3.86
1.7
1.8
1.68
1.66
mmol/l
0.03
15
49
58
348
1.81
3.79
7.2
9.0
1.39
0.88
mmol/l
0.38
43
290
35
180
2.06
3.60
7.3
7.7
24.91
24.61
mmol/l
0.15
35
180
27
125
2.26
3.59
1.6
2.0
1.39
1.50
g/l
0.27
21
113
94
657
1.60
3.50
5.9
4.4
1.02
1.02
kg/l
0.28
61
439
150
1167
1.53
3.47
4.7
3.7
6.18
6.18
ph
0.02
95
681
148
1153
1.52
3.38
5.1
4.1
32.65
45.54
ng/l
0.79
114
847
167
1344
1.50
3.21
23.3
14.5
1.33
1.27
inr
0.67
146
1126
89
628
1.57
3.15
4.3
5.3
—
—
—
0
0
10
27
3.79
2.90
1.3
1.4
—
—
—
0
0
121
933
1.47
2.78
3.0
3.5
2048.75
1411.92
ng/l
0.79
106
796
28
151
1.93
2.56
6.4
3.7
36.93
36.92
°c
0.07
28
151
14
58
2.48
2.40
3.8
2.6
—
—
—
0
0
141
1144
1.41
2.38
5.3
4.1
0.00
0.02
estimate
0.96
35
267
38
233
1.71
2.33
4.0
4.8
1.33
0.57
%
0.74
15
75
11
41
2.74
2.23
2.8
2.5
—
—
—
0
0
107
839
1.41
2.16
5.3
4.5
—
—
—
0
0
105
826
1.40
2.07
5.9
4.2
0.00
0.01
estimate
0.74
32
291
16
77
2.13
2.00
2.6
1.5
—
—
—
0
0
151
1269
1.35
1.96
4.6
5.5
35.24
35.70
g/l
0.44
136
1205
144
1203
1.35
1.93
14.6
12.5
0.00
0.00
e9/l
0.51
124
1002
12
52
2.36
1.90
1.4
2.1
0.31
1.01
g/l
—
7
42
173
1489
1.34
1.89
5.3
4.1
0.00
10.71
estimate
0.80
37
327
38
247
1.61
1.89
4.2
4.8
1.36
0.85
%
0.34
14
85
11
46
2.44
1.87
2.6
1.7
—
—
—
0
0
147
1238
1.34
1.85
3.2
3.0
153.31
134.78
ug/l
0.56
135
1159
36
234
1.61
1.80
4.0
4.9
0.17
0.13
%
0.13
12
71
17
89
1.96
1.73
2.2
1.5
—
—
—
0
0
5
13
3.89
1.72
1.8
1.8
75.20
60.13
%
—
5
8
171
1485
1.32
1.69
5.3
4.1
0.00
0.00
estimate
-0.00
37
320
112
916
1.34
1.69
6.4
6.2
—
—
—
0
0
16
83
1.98
1.67
13.8
8.9
—
—
—
0
0
40
273
1.53
1.64
3.4
2.7
4.21
4.32
kpa
0.14
40
261
46
324
1.49
1.63
3.8
3.4
6.02
5.72
kpa
1.00
46
313
58
428
1.43
1.62
2.8
2.4
19.99
22.54
%
1.01
52
403
5
14
3.61
1.62
1.8
1.7
0.60
1.30
%
—
5
9
282
2649
1.47
1.61
21.0
17.3
22.84
24.21
mg/l
0.29
250
2206
20
114
1.80
1.60
2.0
1.4
—
—
—
0
0
24
145
1.71
1.59
5.4
3.3
—
—
—
0
0
18
101
1.83
1.52
3.9
3.8
24.53
24.73
mmol/l
0.15
18
95
172
1512
1.29
1.49
5.3
4.1
0.00
0.01
estimate
0.50
33
303
117
979
1.30
1.47
3.4
3.3
7.81
8.06
mmol/l
0.23
103
833
7
28
2.53
1.46
1.3
1.1
—
—
—
0
0
229
2095
1.31
1.44
7.9
8.8
74.87
79.62
u/l
1.48
218
1984
36
248
1.51
1.43
4.2
5.2
0.15
0.22
%
0.17
13
72
102
842
1.31
1.41
3.1
3.6
—
—
—
0
0
20
119
1.73
1.41
2.0
1.4
—
—
—
0
0
106
880
1.30
1.41
3.1
2.8
56.72
61.65
u/l
0.37
99
831
39
275
1.47
1.39
2.1
3.1
71.08
70.07
e9/l
0.04
31
209
61
468
1.37
1.38
2.6
2.4
2.29
2.27
g/l
0.12
56
434
20
120
1.71
1.37
2.0
1.4
—
—
—
0
0
9
42
2.17
1.34
1.2
1.5
—
—
—
0
0
9
42
2.17
1.34
1.2
1.5
—
—
—
0
0
9
42
2.17
1.34
1.2
1.5
—
—
—
0
0
9
42
2.17
1.34
1.2
1.5
—
—
—
0
0
37
260
1.48
1.34
8.8
8.6
—
—
—
0
0
20
121
1.70
1.34
2.0
1.4
—
—
—
0
0
17
98
1.77
1.33
1.5
1.2
—
—
—
0
0
41
296
1.44
1.30
1.4
1.5
—
—
—
0
0
20
122
1.68
1.30
2.1
1.4
—
—
—
0
0
8
158
0.49
1.28
1.1
1.3
—
—
—
0
0
205
1863
1.27
1.28
6.0
4.6
—
3.60
—
0
5
61
474
1.35
1.27
1.2
1.3
17.62
32.09
iu/ml
1.32
19
149
14
77
1.85
1.27
1.4
1.5
220.89
267.11
ug/g
—
9
49
48
359
1.40
1.26
2.1
3.1
1.98
1.80
%
0.34
41
331
81
658
1.31
1.25
3.2
2.8
3.21
5.65
e6/l
1.17
76
598
6
25
2.43
1.25
1.2
1.1
—
—
—
0
0
60
469
1.34
1.21
1.6
1.9
—
—
—
0
0
90
746
1.28
1.20
2.8
3.1
356.44
354.83
umol/l
0.05
80
659
100
841
1.27
1.18
3.9
3.5
0.00
0.01
estimate
0.74
32
248
38
276
1.43
1.18
7.1
7.3
1.44
1.35
mmol/l
0.27
38
271
88
730
1.28
1.16
2.4
2.2
2.89
2.90
mg/l
0.02
79
639
15
89
1.72
1.09
1.7
1.6
262.73
343.80
mu/l
0.79
15
83
15
89
1.72
1.09
2.8
4.9
1.52
3.83
ratio
—
6
49
217
2004
1.25
1.09
4.4
4.2
14.99
14.90
pmol/l
0.21
197
1822
49
379
1.34
1.07
1.4
1.3
516.36
551.53
titre
0.05
11
85
54
424
1.33
1.07
1.3
1.3
1.18
7.18
u/ml
1.25
19
155
102
870
1.25
1.06
4.1
4.7
7.39
7.40
ph
0.49
77
622
144
1276
1.23
1.06
7.4
7.1
1.19
1.21
mmol/l
1.60
135
1175
106
910
1.24
1.04
3.3
3.4
41.02
48.26
mg/l
0.19
79
613
109
939
1.24
1.04
4.1
4.0
8.35
8.12
mg/mmol
0.02
80
617
30
214
1.44
1.04
3.2
3.8
64.55
66.60
g/l
0.92
30
201
22
147
1.53
1.03
4.5
3.6
25.12
24.85
mmol/l
0.11
22
142
158
1417
1.22
1.03
7.7
7.8
1.20
1.21
mmol/l
0.35
139
1228
23
156
1.51
1.01
1.0
1.3
203.63
109.40
u/ml
—
9
59
61
493
1.29
0.99
2.7
2.5
11.47
13.04
umol/l
1.14
55
458
73
604
1.27
0.98
1.3
1.3
1.24
1.20
u/ml
0.02
18
173
46
359
1.33
0.95
1.4
1.2
—
—
—
0
0
68
560
1.27
0.95
1.4
1.4
2.78
2.60
g/l
0.24
44
357
56
450
1.29
0.95
2.0
2.0
29.60
29.56
s
0.02
56
437
30
220
1.40
0.91
6.1
3.6
—
—
—
0
0
71
591
1.26
0.91
1.8
1.8
465.80
30664501.30
pmol/l
0.69
61
512
98
1124
0.82
0.91
2.0
2.0
1.77
1.38
mmol/l
1.04
79
941
9
152
0.58
0.91
1.0
1.1
—
—
—
0
0
49
389
1.31
0.91
1.6
1.6
—
—
—
0
0
15
95
1.61
0.89
3.3
5.3
54.61
36.17
mg/l
—
9
81
15
95
1.61
0.89
3.3
5.3
41.08
132.01
mg/l
—
9
81
109
954
1.21
0.88
3.8
3.6
43.24
111.61
e6/l
0.48
89
727
8
46
1.76
0.83
1.9
1.9
—
—
—
0
0
41
323
1.31
0.81
4.0
3.5
7.36
7.38
ph
1.18
23
196
138
1244
1.19
0.80
3.2
2.9
—
—
estimate
—
0
0
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
163
1494
1.18
0.78
5.9
7.3
11.40
12.00
umol/l
0.36
154
1425
0
27
0.00
0.78
0.0
3.8
—
59.83
—
0
6
33
255
1.33
0.75
2.5
2.2
0.00
0.00
estimate
—
5
54
5
26
1.94
0.71
1.4
1.4
—
—
—
0
0
5
26
1.94
0.71
6.8
1.3
27.88
20.52
ng/l
—
5
26
5
27
1.86
0.68
2.4
2.7
38.00
42.97
%
—
5
15
27
207
1.33
0.66
2.6
3.6
78.51
84.04
ng/l
0.19
20
186
5
29
1.74
0.64
1.4
1.4
4117.00
1911.44
e6/l
—
5
18
92
816
1.18
0.63
3.8
3.3
0.36
0.45
e6/l
0.25
76
600
20
147
1.38
0.63
2.1
1.6
0.41
0.37
mg/l
0.08
11
72
66
569
1.20
0.63
4.7
4.2
97.02
296.30
ng/l
1.34
46
457
40
327
1.25
0.62
1.6
1.6
—
—
—
0
0
128
1168
1.16
0.62
5.0
5.1
3.10
2.47
ug/l
0.29
119
1073
0
21
0.00
0.60
0.0
1.0
—
33.97
—
0
21
59
507
1.20
0.58
2.0
1.7
1111.72
1166.95
nmol/l
0.23
49
399
24
185
1.32
0.58
2.8
3.2
—
—
—
0
0
6
35
1.73
0.58
2.0
2.0
—
—
—
0
0
8
54
1.49
0.57
4.4
5.1
14.46
581.39
u/ml
—
8
49
65
565
1.19
0.57
3.6
3.2
500.70
536.34
mosm/kgh2o
0.69
55
494
263
2538
1.19
0.57
6.3
6.6
40.37
39.69
mmol/mol
0.55
246
2399
9
60
1.51
0.55
1.7
2.7
59.26
60.16
%
—
9
60
6
39
1.55
0.53
1.3
1.2
—
—
—
0
0
6
40
1.51
0.52
1.8
2.7
3.80
4.80
e9/l
—
6
40
6
40
1.51
0.52
2.0
2.5
33.00
32.75
pg
—
6
40
116
1064
1.14
0.51
4.4
4.2
203.14
87.46
e6/l
0.40
91
765
41
482
0.83
0.50
3.8
3.2
2.96
1.57
e6/l
0.56
23
258
82
736
1.15
0.49
1.4
1.4
—
—
—
0
0
30
245
1.25
0.49
3.5
4.3
7.28
7.34
ph
0.44
23
175
7
46
1.53
0.48
4.6
2.0
10.57
10.21
mmol/l
—
7
46
22
173
1.29
0.48
2.0
2.5
—
9.40
—
0
13
7
48
1.47
0.47
1.0
1.3
—
—
—
0
0
39
332
1.20
0.44
2.3
2.5
103.09
132.23
ug/g
0.37
26
268
20
158
1.28
0.43
2.0
3.7
4.26
4.41
pmol/l
0.29
20
141
250
2421
1.14
0.43
5.5
5.1
2.06
1.93
mu/l
0.69
232
2231
5
32
1.57
0.42
2.0
1.6
—
—
—
0
0
10
70
1.44
0.42
1.4
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
76.00
—
0
15
8
59
1.36
0.41
1.3
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
2.4
—
3.90
—
0
17
12
88
1.38
0.40
3.0
2.3
1.95
1.50
mg/l
0.97
12
80
0
18
0.00
0.40
0.0
1.0
—
309.40
—
0
10
16
124
1.31
0.39
7.8
1.7
8.81
8.87
iu/ml
—
7
32
91
836
1.12
0.39
1.9
1.7
17.58
19.85
nmol/l
0.67
81
711
129
1212
1.11
0.37
2.5
2.5
74.52
75.46
nmol/l
0.14
116
1087
131
1232
1.11
0.37
2.4
2.1
93.06
93.73
pmol/l
0.06
79
683
5
79
0.63
0.36
1.4
1.1
—
—
—
0
0
21
173
1.23
0.34
1.1
1.2
—
—
—
0
0
6
89
0.67
0.33
4.7
4.8
—
—
—
0
0
24
202
1.20
0.32
4.1
3.2
127.42
129.66
g/l
0.14
24
196
261
2550
1.12
0.31
5.5
5.2
6.11
6.03
mmol/l
0.37
244
2350
7
52
1.35
0.31
7.3
2.2
10.56
8.30
pmol/l
—
7
52
39
345
1.15
0.30
1.6
1.3
—
—
—
0
0
19
157
1.22
0.30
1.1
1.3
—
21.72
—
0
12
194
1872
1.09
0.30
3.8
3.5
55.33
51.47
u/l
0.22
182
1784
8
107
0.74
0.29
1.9
1.9
21.62
21.58
s
—
8
98
88
822
1.10
0.28
6.1
6.6
—
—
—
0
0
23
264
0.86
0.24
1.3
1.4
—
—
—
0
0
255
2501
1.09
0.23
4.1
4.3
1.42
1.31
mmol/l
0.75
234
2311
5
39
1.29
0.23
1.2
1.1
—
—
—
0
0
48
440
1.11
0.23
2.0
2.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
1217.64
—
0
11
0
10
0.00
0.21
0.0
4.2
—
53.90
—
0
10
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
11
89
1.24
0.21
1.6
1.6
—
7.24
—
0
16
0
13
0.00
0.21
0.0
1.2
—
187.82
—
0
13
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
0.64
—
0
9
109
1042
1.07
0.20
2.4
2.1
—
—
—
0
0
6
52
1.16
0.19
1.0
1.1
—
—
—
0
0
101
965
1.07
0.19
2.6
3.5
2.36
2.35
mmol/l
0.29
95
882
23
204
1.14
0.18
1.3
2.0
—
—
—
0
0
275
2715
1.08
0.17
18.2
15.2
—
—
—
0
0
10
120
0.83
0.17
1.8
3.0
15.20
39.22
u/ml
—
10
114
6
80
0.75
0.15
1.0
1.1
—
—
—
0
0
7
87
0.80
0.14
1.3
1.2
—
—
—
0
0
25
227
1.11
0.14
1.4
1.4
—
—
—
0
0
29
266
1.10
0.14
1.6
1.5
—
—
—
0
0
10
84
1.20
0.14
1.3
1.3
—
—
—
0
0
24
263
0.91
0.13
1.6
1.6
—
—
—
0
0
264
2610
1.06
0.13
4.8
5.0
1.37
1.40
mmol/l
0.66
243
2425
22
200
1.11
0.12
1.2
1.2
—
—
—
0
0
14
123
1.14
0.12
1.1
1.3
—
—
—
0
0
92
890
1.05
0.11
2.7
2.5
—
—
—
0
0
12
135
0.88
0.10
2.8
2.3
—
—
—
0
0
264
2617
1.05
0.09
5.0
5.2
4.52
4.52
mmol/l
0.04
245
2446
5
65
0.77
0.08
1.2
1.3
—
—
—
0
0
14
127
1.11
0.08
2.3
1.9
—
—
—
0
0
282
2803
1.04
0.06
12.7
12.4
28.40
27.63
u/l
0.31
273
2738
57
588
0.96
0.06
2.9
3.0
2.47
2.45
mmol/l
0.72
48
534
23
218
1.06
0.05
1.4
1.6
—
—
—
0
0
37
357
1.04
0.05
1.3
1.5
—
—
—
0
0
286
2873
0.96
0.04
31.5
25.7
242.25
242.61
e9/l
0.03
281
2829
30
311
0.96
0.04
1.5
1.3
—
—
—
0
0
26
267
0.97
0.01
2.3
2.6
32.00
30.76
u/l
0.15
18
224
36
353
1.02
0.01
2.3
1.7
—
—
—
0
0
10
94
1.07
0.01
1.3
1.1
—
—
—
0
0
10
106
0.94
0.01
1.8
1.8
—
—
—
0
0
12
122
0.98
0.00
2.3
2.9
—
—
—
0
0
21
209
1.01
0.00
1.3
1.8
3.99
3.51
mmol/l
0.95
14
155
107
1069
1.00
0.00
3.3
3.3
—
—
—
0
0
70
705
0.99
0.00
3.0
3.0
0.78
0.80
ug/l
0.05
47
434
287
2875
0.99
0.00
31.4
25.7
6.81
6.79
e9/l
0.06
281
2823
287
2875
0.99
0.00
31.4
25.6
4.53
4.53
e12/l
0.06
280
2823
267
2666
1.01
0.00
5.5
5.8
2.62
2.65
mmol/l
0.14
245
2484
0
6
0.00
0.00
0.0
1.0
—
22.50
—
0
6
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
9
93
0.97
0.00
1.1
1.2
—
0.73
—
0
12
0
6
0.00
0.00
0.0
1.2
—
59.00
—
0
6
0
6
0.00
0.00
0.0
1.0
—
35.98
—
0
6
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
68.46
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
6
59
1.02
-0.00
1.2
1.3
—
160.52
—
0
18
0
7
0.00
-0.00
0.0
4.6
—
7.52
—
0
7
0
7
0.00
-0.00
0.0
3.3
—
1.01
—
0
7
6
59
1.02
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
28.44
—
0
9
0
8
0.00
-0.00
0.0
1.1
—
12.68
—
0
8
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.3
—
7147.38
—
0
8
0
7
0.00
-0.00
0.0
12.1
—
4.81
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
10.20
—
0
5
5
56
0.89
-0.00
1.0
1.1
—
—
—
0
0
5
49
1.02
-0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
1.19
—
0
8
5
49
1.02
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint J10_CHEMGASRESP and mortality.

Females

Parameter HR [95% CI] p-value
J10_CHEMGASRESP 2.547 [1.64, 3.96] < 0.001
Birth year 0.991 [0.98, 1.0] 0.057

During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 394 females with J10_CHEMGASRESP died.

Males

Parameter HR [95% CI] p-value
J10_CHEMGASRESP 2.008 [1.58, 2.55] < 0.001
Birth year 0.992 [0.98, 1.0] 0.069

During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 908 males with J10_CHEMGASRESP died.

Mortality risk

Mortality risk for people of age

years, who have J10_CHEMGASRESP.

N-year risk Females Males
1 0.175% 0.377%
5 1.164% 2.493%
10 3.067% 6.557%
15 6.139% 12.833%
20 10.725% 21.588%

Relationships between endpoints

Index endpoint: J10_CHEMGASRESP – Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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