asbestosis: A pneumoconiosis caused by inhalation and retention of asbestos fibers.
Pneumoconiosis due to asbestos and other mineral fibres
DOID EFO Endpoint Browser PheWeb
J10_ASBESTPNEUMOC
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
943 |
4. Check minimum number of eventsNone |
943 |
5. Include endpointsNone |
943 |
6. Filter based on genotype QC (FinnGen only) |
851 |
Control definitions (FinnGen only)
- Control exclude
- J10_EXTERLUNG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J60-J70
- Name in latin
- Asbestosis
Similar endpoints
↥List of similar endpoints to
Pneumoconiosis due to asbestos and other mineral fibres
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6025 | 326 | 5496 |
| Only index persons | 3520 | 209 | 3311 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.01 | 0.15 |
| Only index persons | 0.12 | 0.01 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 71.18 | 71.89 | 71.13 |
| Only index persons | 71.74 | 71.88 | 71.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 851 | 31 | 820 |
| Unadjusted period prevalence (%) | 0.36 | 0.01 | 0.38 |
| Median age at first event (years) | 70.87 | 60.98 | 71.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 866
- Matched controls
- 8660
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J61
ICD-10 Finland
Pneumoconiosis due to asbestos and other mineral fibres
4503599627370496.0
307.7
803
*
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
86.6
307.7
548
169
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
12.9
198.2
216
218
XG410
NOMESCO Finland
Flow-volume spirometry
9.8
117.4
148
178
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
12.1
110.4
117
110
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
10.0
108.7
134
156
5010A
ICD-9 Finland
Asbestosis[ASBESTOSIS]
+∞
90.2
85
*
Z57.2
ICD-10 Finland
Occupational exposure to dust
23.9
74.5
54
24
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
6.4
73.6
133
237
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.4
70.2
217
614
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.0
70.1
257
823
5110B
ICD-9 Finland
Pleurisy, Without mention of effusion or current tuberculosis[PLEURA-ADHEESIOT]
26.7
69.1
48
19
R03BB04
ATC
tiotropium bromide; inhalant
3.8
67.7
277
954
R03AC02
ATC
salbutamol; inhalant
3.4
66.9
533
2771
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
7.9
63.0
91
127
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.2
56.4
319
1326
TGC00
NOMESCO Finland
Bronchial lavation
7.6
52.0
77
110
J96.1
ICD-10 Finland
Chronic respiratory failure
5.9
47.9
92
172
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
12.8
45.6
45
37
J92.9
ICD-10 Finland
Pleural plaque without asbestos
7.5
45.1
67
96
R03AK03
ATC
[U] fenoterol and ipratropium bromide
3.3
40.7
181
638
H02AB06
ATC
prednisolone; systemic
2.5
37.7
507
3121
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.3
34.3
148
509
GD1AD
NOMESCO Finland
Thorax CT examination
3.9
34.2
110
312
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.6
33.7
261
1232
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.5
32.4
65
126
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.0
32.1
100
277
R06.0
ICD-10 Finland
Dyspnoea
2.4
31.7
339
1846
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.7
31.4
209
911
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
4.8
30.4
72
161
J45.9
ICD-10 Finland
Asthma, unspecified
2.6
28.8
199
881
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
4.8
25.1
58
127
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
24.8
494
3354
R03BB01
ATC
ipratropium bromide; inhalant
3.0
24.5
118
429
R03BA05
ATC
fluticasone; inhalant
2.6
24.0
171
762
R03BA01
ATC
beclometasone; inhalant
2.5
21.8
155
689
J94.8
ICD-10 Finland
Other specified pleural conditions
5.0
21.5
47
98
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
6.2
21.4
37
62
R03BA02
ATC
budesonide; inhalant
2.4
20.5
162
754
Z57.3
ICD-10 Finland
Occupational exposure to other air contaminants
59.0
20.0
23
*
J45.1
ICD-10 Finland
Nonallergic asthma
3.1
19.3
85
293
1240
FHL
Bronchoscopy
4.9
19.1
43
92
R03DA04
ATC
theophylline; systemic, rectal
2.6
19.1
127
545
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.0
18.5
86
305
XX1AW
NOMESCO Finland
Written report from X-ray examination without contrast peformed elsewhere
27.4
17.9
24
9
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.9
17.5
85
309
8070/3-C34.9
ICD-O-3
Squamous cell carcinoma, NOS, of lung, NOS
4.3
17.4
45
108
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.5
17.3
123
544
5150X
ICD-9 Finland
Postinflammatory pulmonary fibrosis[FIBROSIS PULMONUM E CAUSA IGNOTA]
26.2
17.0
23
9
R04.2
ICD-10 Finland
Haemoptysis
3.1
16.5
72
246
XX1XW
NOMESCO Finland
Extensive written report from radiologist
5.1
16.5
35
71
R03AC13
ATC
formoterol; inhalant
3.1
16.2
70
238
R03BA08
ATC
ciclesonide; inhalant
3.1
15.9
68
230
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
34.1
15.8
20
6
R03AK08
ATC
formoterol and beclometasone; inhalant
4.2
15.4
42
105
J01AA02
ATC
doxycycline; systemic
1.9
15.3
625
5012
R06.2
ICD-10 Finland
Wheezing
3.6
14.9
49
140
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
6.9
14.9
23
34
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
3.5
14.7
52
156
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
3.9
14.4
43
115
J92
ICD-10 Finland
Pleural plaque
22.7
14.3
20
9
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
14.2
391
2771
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
3.8
13.8
42
114
J47
ICD-10 Finland
Bronchiectasis
4.4
13.7
35
83
51520
ICD-8 Finland
Pneumoconiosis due to silica and silicates, Asbestosis
+∞
13.6
13
*
H02AB04
ATC
methylprednisolone; systemic
2.1
13.0
132
675
R02
ICPC
Shortness of breath/dyspnoea
2.1
13.0
137
711
R03AK07
ATC
formoterol and budesonide; inhalant
2.0
12.8
146
780
R03AC03
ATC
terbutaline; inhalant
2.2
12.8
111
533
R05
ICD-10 Finland
Cough
2.0
12.7
157
863
C34.3
ICD-10 Finland
Malignant neoplasm: Lower lobe, bronchus or lung
3.6
12.5
41
117
R03AC12
ATC
salmeterol; inhalant
2.5
12.1
80
340
R95
ICPC
Chron obstructive pulmonary disease
2.9
11.9
58
211
XG466
NOMESCO Finland
Sleep oxymetry
3.4
11.9
43
131
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
8.5
11.3
24
29
GX1K5
NOMESCO Finland
Diffusion capacity
18.1
10.8
16
9
R99
ICPC
Respiratory disease other
4.0
10.6
30
77
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.6
10.6
372
2749
XG405
NOMESCO Finland
Education on PEF monitoring
8.3
10.4
22
27
R03BB02
ATC
oxitropium bromide; inhalant
4.0
10.1
28
71
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
9.7
174
1072
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.7
9.6
187
1181
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.6
9.5
55
220
4912A
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS CHRONICA OBSTRUCTIVA]
4.3
9.2
23
54
WX725
NOMESCO Finland
Noninvasive ventilation
2.7
9.1
50
194
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
9.1
164
1012
356
Kela drug reimbursment
Nintedanib and pirfenidone
10.8
8.8
16
15
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
3.7
8.8
27
74
GAC00
NOMESCO Finland
Biopsy of pleura
8.3
8.6
18
22
Y96.0
ICD-10 Finland
Work-related condition
27.8
8.5
11
*
J01FA06
ATC
roxithromycin; oral
1.6
8.4
293
2133
7931A
ICD-9 Finland
Nonspecific abnormal findings on radiological and other examination of body structure, Lung field
6.6
8.2
20
31
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
2.9
8.2
38
135
XG474
NOMESCO Finland
Exhalation nntrogen oxide
4.4
8.2
20
46
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
3.2
8.0
31
99
N02AX02
ATC
tramadol; systemic, rectal
1.5
7.7
358
2759
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
4.4
7.7
19
44
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
8.1
7.6
16
20
R03DC03
ATC
montelukast; oral
2.0
7.6
87
463
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
7.6
330
2508
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.6
7.5
192
1293
J62.8
ICD-10 Finland
Pneumoconiosis due to other dust containing silica
+∞
7.3
7
*
5188X
ICD-9 Finland
Other diseases of lung
7.4
7.2
16
22
8041/3-C34.9
ICD-O-3
Small cell carcinoma, NOS, of lung, NOS
4.0
7.2
20
51
R05
ICPC
Cough
1.7
7.2
145
920
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.2
7.1
57
265
L01EX09
ATC
nintedanib; oral
12.1
7.1
12
10
5119X
ICD-9 Finland
Pleurisy, Unspecified pleural effusion
5.5
6.9
19
35
J96.0
ICD-10 Finland
Acute respiratory failure
3.2
6.9
27
87
TGW99
NOMESCO Finland
Other minor procedure in thoracic surgery
13.9
6.9
11
8
284
Kela drug reimbursment
Nintedanib and pirfenidone
8.4
6.8
14
17
L01
ICPC
Neck symptom/complaint
2.0
6.8
76
401
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
6.0
6.6
17
29
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.7
6.6
141
906
J46
ICD-10 Finland
Status asthmaticus
3.3
6.6
24
74
GDC00
NOMESCO Finland
Lobectomy of lung
5.8
6.5
17
30
TGA30
NOMESCO Finland
Thoracocentesis
3.9
6.3
18
47
J62.0
ICD-10 Finland
Pneumoconiosis due to talc dust
+∞
6.3
6
*
L03
ICPC
Low back symptom/complaint
1.6
6.2
150
995
J43.2
ICD-10 Finland
Centrilobular emphysema
7.7
6.1
13
17
M01AE02
ATC
naproxen; oral, rectal
1.4
6.0
333
2623
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
142
622
2.53
20.49
7.1
3.9
5.45
5.12
kpa
3.34
134
586
121
537
2.46
16.83
7.3
3.9
2.63
1.91
mmol/l
1.14
98
383
81
310
2.78
15.17
8.9
4.3
25.88
24.55
mmol/l
2.85
74
279
85
349
2.59
13.86
3.4
2.7
—
—
—
0
0
100
465
2.30
12.42
1.5
1.4
—
—
—
0
0
122
662
1.98
10.13
1.3
1.2
30.07
40.32
iu/ml
0.68
38
204
26
65
4.09
9.56
3.8
3.1
—
—
—
0
0
50
198
2.62
8.79
1.9
1.6
—
—
—
0
0
24
63
3.89
8.29
1.2
1.8
—
—
—
0
0
24
63
3.89
8.29
1.2
1.8
—
—
—
0
0
24
63
3.89
8.29
1.2
1.8
—
—
—
0
0
168
1069
1.71
8.27
6.5
6.6
5.18
5.06
kpa
0.79
160
1024
168
1069
1.71
8.27
6.5
6.6
10.01
11.43
kpa
4.17
160
1023
24
66
3.71
7.78
1.5
1.9
—
—
—
0
0
48
199
2.49
7.71
1.9
1.6
—
—
—
0
0
24
69
3.55
7.31
1.6
1.9
—
—
—
0
0
163
1064
1.66
7.23
6.6
6.6
1.65
0.94
mmol/l
1.38
133
846
30
103
2.98
6.91
1.2
1.2
—
—
—
0
0
121
739
1.74
6.85
5.7
5.3
33.64
32.92
%
0.24
77
475
35
135
2.66
6.53
1.5
1.6
—
—
—
0
0
346
2755
1.43
5.88
4.7
3.6
2212.10
2544.64
ng/l
0.70
310
2469
214
1560
1.49
5.76
2.5
2.0
—
—
—
0
0
20
60
3.39
5.75
2.3
1.5
—
—
—
0
0
100
611
1.72
5.64
1.3
1.2
6.59
15.68
u/ml
1.20
27
206
31
124
2.56
5.42
1.3
1.4
—
—
—
0
0
90
541
1.74
5.39
6.3
8.7
25.03
24.12
mmol/l
1.80
84
527
27
101
2.73
5.38
1.8
1.5
—
—
—
0
0
26
97
2.73
5.21
3.7
3.4
—
—
—
0
0
26
97
2.73
5.21
3.1
2.6
27.33
22.03
mg/l
—
9
30
16
35
4.64
5.19
1.3
1.1
—
—
—
0
0
26
99
2.68
5.02
1.3
1.1
5.89
2.21
u/ml
—
7
8
406
3396
1.37
4.88
7.9
8.4
4.93
4.58
e9/l
1.50
344
2911
60
334
1.86
4.65
2.2
1.8
—
—
—
0
0
15
35
4.34
4.64
1.2
2.0
—
—
—
0
0
15
35
4.34
4.64
1.2
2.0
—
—
—
0
0
15
35
4.34
4.64
1.2
2.0
—
—
—
0
0
15
35
4.34
4.64
1.2
2.0
—
—
—
0
0
42
208
2.07
4.55
2.4
2.3
138.50
126.16
g/l
1.87
28
164
34
155
2.24
4.52
1.4
1.5
12.22
9.27
iu/ml
0.16
11
41
31
139
2.28
4.29
1.8
1.4
—
—
—
0
0
34
159
2.18
4.26
1.9
1.4
—
—
—
0
0
162
1182
1.46
4.25
1.6
1.7
1.28
1.91
mg/l
2.31
122
956
63
367
1.77
4.23
2.5
2.0
—
—
—
0
0
28
121
2.36
4.21
1.2
1.1
—
—
—
0
0
113
769
1.54
4.15
12.0
9.9
—
—
—
0
0
12
26
4.66
4.06
1.2
2.0
—
—
—
0
0
12
26
4.66
4.06
1.2
2.0
—
—
—
0
0
31
144
2.20
3.97
1.4
1.4
—
—
—
0
0
343
4027
0.75
3.92
38.3
30.7
329.96
331.09
g/l
1.43
335
3984
41
217
1.93
3.74
2.0
1.5
—
—
—
0
0
11
28
3.96
3.29
1.4
2.0
—
—
—
0
0
13
39
3.37
3.23
1.4
1.3
1.90
150.86
ug/l
—
7
14
474
4219
1.27
3.08
6.4
4.2
17.99
15.91
mm/h
1.70
443
3866
36
198
1.85
2.98
3.1
2.6
16.63
15.97
%
0.62
36
192
44
260
1.73
2.89
4.2
3.1
7.82
7.57
kpa
0.43
44
252
24
118
2.06
2.74
11.2
4.9
989.86
1387.53
iu/ml
—
7
19
107
790
1.40
2.63
1.7
2.5
67.47
65.82
g/l
1.58
92
715
390
3443
1.24
2.54
6.8
6.5
14.88
13.95
umol/l
0.31
367
3280
67
456
1.51
2.52
1.8
1.8
0.71
2.52
ug/l
1.24
53
390
106
792
1.39
2.44
3.1
2.5
6.88
6.50
ug/l
0.10
84
683
20
96
2.11
2.44
2.2
1.5
—
—
—
0
0
20
98
2.07
2.33
1.5
1.4
13.05
14.00
u/l
0.36
20
93
217
1810
1.27
2.30
3.6
3.3
386.30
385.94
umol/l
0.02
172
1526
9
31
2.92
2.07
1.1
1.2
—
—
—
0
0
355
3154
1.21
2.06
3.7
3.3
69.94
64.50
u/l
0.35
314
2882
250
2154
1.23
1.96
2.7
2.2
221.93
278.67
u/l
0.45
234
2022
11
45
2.46
1.93
1.0
1.3
—
—
—
0
0
37
235
1.60
1.93
3.2
3.3
0.70
0.88
nmol/l
2.79
24
189
23
129
1.80
1.87
1.4
1.4
415.85
308.37
u/l
0.44
23
123
5
12
4.18
1.82
1.0
1.6
45.60
39.00
umol/l
—
5
12
373
4097
0.84
1.72
33.5
28.2
14.37
14.17
%
1.84
366
4034
355
3199
1.19
1.69
7.7
6.8
1.20
1.20
mmol/l
0.54
320
2924
328
2936
1.19
1.68
7.3
4.9
65.51
86.69
ng/l
0.40
281
2447
118
1448
0.79
1.66
2.9
3.2
2.49
2.45
mmol/l
4.00
108
1279
141
1166
1.25
1.61
2.2
1.8
—
—
—
0
0
323
3575
0.85
1.60
5.1
5.3
22.62
22.50
%
0.05
176
1982
14
71
1.99
1.54
1.3
1.5
—
—
—
0
0
12
232
0.51
1.54
5.4
3.7
1.23
1.70
mmol/l
2.58
12
224
450
4162
1.17
1.51
6.1
5.2
4.40
1418.33
e6/l
—
5
100
29
190
1.54
1.39
1.3
1.4
—
—
—
0
0
29
190
1.54
1.39
1.3
1.4
—
—
—
0
0
12
60
2.01
1.38
1.2
1.5
—
—
—
0
0
6
23
2.62
1.37
2.5
1.4
—
—
—
0
0
25
159
1.59
1.36
1.0
1.1
43.10
131.50
u/ml
—
8
53
75
591
1.29
1.29
1.9
1.7
—
—
—
0
0
10
48
2.10
1.28
2.1
2.4
—
—
—
0
0
60
459
1.33
1.28
1.6
1.5
—
—
—
0
0
406
3767
1.15
1.22
23.4
24.3
1.48
1.47
inr
0.08
349
3270
128
1083
1.21
1.20
2.3
1.9
—
—
—
0
0
67
533
1.28
1.10
4.1
4.8
96.16
115.78
ng/l
1.01
58
456
5
21
2.39
1.09
1.4
1.8
0.64
0.63
mmol/l
—
5
21
247
2230
1.15
1.08
3.9
3.5
7.34
7.59
mmol/l
0.55
199
1851
207
1845
1.16
1.08
4.8
4.2
0.00
0.00
estimate
0.50
62
592
228
2047
1.15
1.08
3.1
2.6
60.46
98.26
u/l
0.48
202
1906
14
82
1.72
1.05
3.5
3.1
—
—
—
0
0
11
190
0.57
1.03
4.5
3.9
20.23
32.74
mg/l
—
6
148
13
75
1.74
1.03
1.2
1.4
—
—
—
0
0
25
172
1.47
1.01
1.7
1.4
1087.63
1868.87
e6/l
1.29
19
117
13
76
1.72
0.99
1.2
1.4
—
—
—
0
0
35
468
0.74
0.99
5.3
4.4
52.31
47.39
%
0.55
35
460
0
29
0.00
0.98
0.0
2.0
—
56.44
—
0
24
13
77
1.70
0.95
1.2
1.4
—
—
—
0
0
46
357
1.30
0.93
1.4
1.2
—
—
—
0
0
257
2353
1.13
0.91
2.3
2.3
79.21
77.83
nmol/l
0.32
210
2008
7
128
0.54
0.88
1.9
2.5
3.56
3.27
ratio
—
7
108
380
3567
1.12
0.87
8.4
7.7
1.20
1.20
mmol/l
0.37
309
3016
8
44
1.83
0.86
1.1
1.1
—
83.75
—
0
8
243
2225
1.13
0.85
2.6
2.4
3.33
2.88
mg/l
1.53
198
1913
16
104
1.55
0.85
1.1
1.1
—
—
—
0
0
22
154
1.44
0.84
1.7
1.4
353582.77
78201.76
e6/l
0.50
13
90
6
32
1.88
0.82
1.0
1.1
40.45
37.65
g/l
—
6
32
124
1090
1.16
0.79
2.7
3.6
241.64
248.48
u/l
0.35
117
1022
0
24
0.00
0.79
0.0
1.7
—
8.72
—
0
15
0
24
0.00
0.79
0.0
1.0
—
—
—
0
0
6
33
1.82
0.79
1.0
1.1
—
—
—
0
0
15
98
1.54
0.79
1.6
1.2
—
—
—
0
0
58
479
1.23
0.75
3.5
3.9
24.80
23.76
mmol/l
1.11
58
474
25
185
1.36
0.72
1.5
1.3
—
—
—
0
0
12
76
1.59
0.72
1.3
1.4
—
—
—
0
0
22
298
0.73
0.72
1.5
1.3
—
—
—
0
0
7
41
1.71
0.70
1.3
1.6
—
—
—
0
0
249
2310
1.11
0.69
4.9
4.3
12.48
12.27
mg/mmol
0.02
159
1605
12
77
1.57
0.68
1.3
1.4
—
—
—
0
0
12
77
1.57
0.68
1.3
1.4
—
—
—
0
0
16
110
1.46
0.68
1.6
1.6
—
—
—
0
0
483
4631
1.10
0.68
10.1
8.4
88.91
86.39
u/l
0.33
454
4356
7
117
0.60
0.68
1.7
1.3
—
—
—
0
0
78
671
1.18
0.67
2.3
2.1
0.18
0.19
g/l
0.93
68
606
7
43
1.63
0.67
1.3
1.6
—
—
—
0
0
7
44
1.60
0.65
1.0
1.2
—
—
—
0
0
283
2655
1.10
0.63
3.4
3.2
169.97
181.56
ug/l
0.39
246
2404
22
164
1.35
0.63
1.5
1.5
300.13
246.24
ug/g
0.78
15
110
183
1685
1.11
0.59
2.0
1.9
1190.81
1152.39
nmol/l
0.24
119
1289
8
52
1.54
0.59
1.1
1.5
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
6
35
1.72
0.57
1.0
1.1
—
—
—
0
0
39
321
1.23
0.55
1.7
3.1
34.43
87.63
mg/l
0.85
34
277
16
116
1.39
0.54
1.8
1.8
85.43
89.08
%
0.88
16
116
487
5038
0.92
0.54
6.7
6.2
2.24
2.29
mmol/l
0.56
417
4512
9
60
1.51
0.54
1.4
1.3
—
—
—
0
0
9
60
1.51
0.54
1.4
1.3
—
—
—
0
0
6
39
1.54
0.53
1.5
1.3
—
—
—
0
0
6
39
1.54
0.53
1.5
1.3
—
—
—
0
0
482
4984
0.93
0.52
8.6
7.7
41.89
41.36
mmol/mol
0.65
408
4522
139
1271
1.11
0.52
3.2
2.9
21.21
22.08
%
0.34
124
1185
89
792
1.14
0.52
3.9
3.2
217.57
288.71
ng/l
1.30
83
722
6
40
1.50
0.51
1.0
1.1
—
—
—
0
0
9
64
1.41
0.51
1.1
1.0
—
—
—
0
0
9
65
1.39
0.50
1.3
1.2
—
—
—
0
0
20
154
1.31
0.49
1.8
1.8
1.69
1.64
mmol/l
0.12
20
149
329
3139
1.08
0.49
5.7
5.3
32.74
33.73
g/l
2.33
295
2918
147
1359
1.10
0.46
3.1
2.8
2.25
2.14
g/l
1.79
132
1254
247
2336
1.08
0.46
2.6
2.2
—
—
—
0
0
194
1817
1.09
0.45
3.9
3.0
33.48
38.36
u/l
0.75
182
1724
11
77
1.43
0.45
1.0
1.1
1.63
1.66
g/l
0.06
11
69
17
130
1.31
0.44
1.0
1.0
—
—
—
0
0
5
31
1.62
0.43
1.6
3.4
9.14
10.00
kpa
—
5
31
5
31
1.62
0.43
1.6
3.4
4.50
5.10
kpa
—
5
31
323
3093
1.07
0.43
4.7
4.2
0.06
4.39
estimate
0.79
81
732
5
32
1.57
0.42
1.4
1.4
0.99
0.90
g/l
—
5
32
161
1503
1.09
0.41
5.8
4.4
364.55
310.13
ng/l
0.13
141
1364
5
33
1.52
0.41
1.0
1.1
—
—
—
0
0
5
33
1.52
0.41
1.6
2.5
—
—
—
0
0
14
105
1.34
0.41
4.1
3.7
13.83
12.87
pmol/l
0.12
14
105
475
4885
0.94
0.40
6.1
5.3
3.93
4.03
mmol/l
1.29
407
4411
152
1626
0.92
0.39
4.4
3.8
4.31
0.09
estimate
0.48
58
528
65
580
1.13
0.39
3.8
3.8
1.22
1.21
mmol/l
0.46
56
500
5
35
1.43
0.39
1.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
175
1645
1.08
0.38
2.3
2.6
—
—
—
0
0
74
819
0.89
0.38
2.6
4.1
11.10
39.66
ug/l
1.33
62
684
45
514
0.87
0.38
1.8
1.7
1.62
1.47
g/l
0.57
36
440
327
3146
1.06
0.37
2.4
2.4
95.17
90.41
pmol/l
0.90
184
1837
21
170
1.24
0.37
1.2
1.4
—
—
—
0
0
9
69
1.31
0.37
2.0
1.5
—
—
—
0
0
484
4962
0.94
0.35
27.4
23.0
66.76
67.03
ml/min/173m2
0.11
448
4683
471
4831
0.95
0.35
6.1
5.3
1.28
1.32
mmol/l
1.55
400
4302
277
2883
0.94
0.34
3.1
3.1
—
—
estimate
—
0
0
242
2528
0.94
0.33
3.4
3.7
0.84
0.86
ug/l
0.11
181
1848
6
86
0.70
0.33
7.3
3.5
310.17
325.80
umol/l
—
6
75
61
552
1.11
0.31
2.9
2.5
36.83
39.03
u/l
0.17
52
453
23
193
1.20
0.31
3.5
3.7
1.29
1.30
index
0.00
14
105
17
138
1.24
0.30
1.4
1.5
6.89
6.39
mmol/l
0.27
17
132
21
249
0.84
0.29
1.6
1.6
—
—
—
0
0
314
3039
1.05
0.29
4.6
4.2
0.00
0.00
estimate
-0.00
79
715
464
4745
0.95
0.29
5.3
4.4
2.18
2.14
mu/l
0.18
400
4187
496
5062
0.95
0.28
6.7
5.8
6.23
6.23
mmol/l
0.01
417
4467
551
5609
0.95
0.28
42.6
33.8
229.89
222.35
e9/l
1.83
528
5452
551
5609
0.95
0.28
42.5
33.7
4.38
4.31
e12/l
2.35
524
5429
551
5609
0.95
0.28
43.2
34.4
40.07
38.92
%
5.86
531
5494
551
5609
0.95
0.28
38.3
30.6
99.31
98.96
umol/l
0.06
534
5504
551
5609
0.95
0.28
42.8
34.0
132.25
130.60
g/l
1.63
533
5503
71
653
1.10
0.28
2.2
2.4
10.35
11.41
nmol/l
0.52
59
550
551
5608
0.95
0.28
42.4
33.6
92.57
92.45
fl
0.21
532
5498
118
1111
1.07
0.27
6.5
6.1
1.02
1.04
mmol/l
0.29
110
1033
10
77
1.30
0.26
1.2
1.4
—
—
—
0
0
154
1466
1.06
0.26
3.1
2.8
11.44
11.65
umol/l
0.15
134
1362
320
3107
1.05
0.26
4.8
4.2
0.00
0.45
estimate
0.51
76
678
408
3987
1.04
0.24
6.8
5.5
6.87
7.00
mmol/l
0.77
392
3851
118
1246
0.94
0.24
4.1
3.6
0.64
0.80
e6/l
0.31
59
733
53
486
1.10
0.23
2.8
2.2
375.93
391.21
nmol/l
0.18
46
439
536
5446
0.96
0.23
15.6
12.8
25.15
24.95
u/l
0.08
507
5209
13
157
0.83
0.22
1.9
2.1
93.38
85.79
%
0.71
13
151
550
5581
0.96
0.22
35.7
28.5
4.09
4.07
mmol/l
1.68
529
5449
361
3693
0.96
0.21
4.2
3.4
15.39
15.15
pmol/l
0.86
313
3224
0
11
0.00
0.21
0.0
1.0
—
1725.18
—
0
11
0
10
0.00
0.21
0.0
1.0
—
1.17
—
0
10
0
10
0.00
0.21
0.0
3.3
—
188.61
—
0
10
550
5579
0.96
0.21
35.7
28.2
139.27
139.56
mmol/l
1.75
531
5449
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
33
297
1.12
0.20
1.8
2.9
1.77
2.53
ratio
0.91
24
175
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
80
753
1.07
0.20
2.9
2.8
16.43
11.04
umol/l
0.63
73
678
22
193
1.14
0.19
2.5
2.3
58.24
113.84
ug/min
—
10
120
227
2335
0.96
0.18
4.8
4.4
7.58
0.03
estimate
0.49
66
600
160
1657
0.96
0.17
1.8
1.8
423.57
4194671.34
pmol/l
0.50
112
1359
54
504
1.08
0.17
3.5
3.3
55.61
55.51
ml/min/173m2
0.01
28
237
14
120
1.17
0.16
1.1
1.3
—
—
—
0
0
36
331
1.09
0.16
2.1
2.5
1.41
1.59
g/l
0.09
29
283
544
5376
1.03
0.16
30.2
22.7
29.36
32.42
mg/l
1.23
498
4745
16
140
1.15
0.15
1.3
1.4
1.17
1.10
g/l
0.40
16
135
89
851
1.05
0.15
8.8
6.9
12.69
12.88
mmol/l
0.08
83
813
11
93
1.19
0.14
1.5
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
40
374
1.07
0.13
2.1
2.4
0.32
0.35
iu/ml
0.21
20
209
14
123
1.14
0.12
1.8
1.2
—
—
—
0
0
14
123
1.14
0.12
1.8
1.2
—
—
—
0
0
462
4672
0.98
0.12
5.1
4.5
1.26
1.21
mmol/l
0.74
393
4126
32
342
0.93
0.11
2.2
2.5
11.97
11.42
g/l
0.24
26
300
18
163
1.11
0.11
1.3
1.6
—
—
—
0
0
25
231
1.08
0.10
1.8
1.6
—
—
—
0
0
83
859
0.96
0.10
1.2
1.2
1.46
1.66
u/ml
0.13
18
197
5
47
1.06
0.09
1.0
1.1
—
—
—
0
0
214
2103
1.02
0.09
4.5
3.7
0.49
0.52
e6/l
0.07
153
1670
59
567
1.04
0.09
1.6
1.7
—
—
—
0
0
126
1230
1.03
0.09
4.4
3.0
0.81
0.82
mmol/l
0.97
119
1150
5
61
0.82
0.08
1.6
1.1
1.48
1.68
nmol/l
—
5
54
267
2703
0.98
0.07
5.0
3.8
—
—
—
0
0
245
2481
0.98
0.07
4.7
3.8
274.26
155.01
e6/l
0.24
188
2014
9
86
1.05
0.07
1.6
1.1
—
—
—
0
0
38
364
1.05
0.06
2.1
2.4
3.02
2.99
g/l
0.09
33
325
9
105
0.86
0.06
1.0
1.1
—
14.12
—
0
5
137
1393
0.98
0.06
5.0
4.6
1.02
1.02
kg/l
1.28
99
973
226
2286
0.98
0.06
2.0
1.9
19.11
18.97
nmol/l
0.05
185
1944
223
2254
0.99
0.05
3.2
3.4
2.34
2.33
mmol/l
0.89
199
2025
441
4436
0.99
0.05
6.6
6.4
5.89
5.05
ug/l
0.14
366
3905
38
393
0.97
0.04
2.1
2.4
4.04
3.77
g/l
0.49
33
353
180
1818
0.99
0.04
3.8
2.8
3.34
3.25
e6/l
0.04
165
1662
176
1776
0.99
0.03
2.1
1.9
1.27
1.21
mmol/l
0.39
139
1413
260
2616
0.99
0.03
5.5
4.4
232.65
137.47
e6/l
0.31
187
2055
11
118
0.93
0.02
3.7
5.9
11.09
12.42
mg/l
0.57
11
113
14
132
1.06
0.02
1.9
1.2
—
—
—
0
0
82
809
1.02
0.02
5.6
4.1
—
—
—
0
0
128
1290
0.99
0.01
3.6
3.5
1.17
0.96
e6/l
0.33
69
781
87
874
0.99
0.00
3.6
3.9
2.78
1.63
mmol/l
1.17
78
722
41
408
1.01
0.00
1.5
1.6
1.65
1.81
%
0.63
31
313
39
393
0.99
0.00
2.1
2.4
4.18
4.13
g/l
0.20
34
355
39
393
0.99
0.00
2.1
2.4
7.82
7.33
g/l
1.24
34
354
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
8.90
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
37.29
—
0
7
0
6
0.00
-0.00
0.0
4.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.1
—
13.59
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
1.0
1.5
3.28
5.78
mg/l
—
5
53
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
15.00
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
52
0.96
-0.00
1.4
1.2
0.24
0.19
nmol/l
—
5
45
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint J10_ASBESTPNEUMOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ASBESTPNEUMOC | 1.687 [1.26, 2.25] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.642 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 200 females with J10_ASBESTPNEUMOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ASBESTPNEUMOC | 1.879 [1.69, 2.09] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 2029 out of 3332 males with J10_ASBESTPNEUMOC died.
Mortality risk
Mortality risk for people of age
years, who have J10_ASBESTPNEUMOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.176% | 0.358% |
| 5 | 1.034% | 2.316% |
| 10 | 2.786% | 5.423% |
| 15 | 5.368% | 10.024% |
| 20 | 9.573% | 16.505% |
Relationships between endpoints
↥Index endpoint: J10_ASBESTPNEUMOC – Pneumoconiosis due to asbestos and other mineral fibres
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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