This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
ILD and respiratory illness in diseases classified elsewhere
ILD_ELSEWHERE
interstitial lung disease: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of pulmonary alveoli that extends to the interstitium and beyond leading to diffuse pulmonary fibrosis. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditions
|
547 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
209 |
6. Filter based on genotype QC (FinnGen only) |
193 |
Control definitions (FinnGen only)
- Control exclude
- ILD_ENDPOINTS
- Control conditions
- not RESP_ILL_DIS_CLASS_ELSEWHERE
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
ILD and respiratory illness in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Respiratory disorders in diseases classified elsewhere
- Interstitial lung disease
- Interstitial lung disease endpoints
- Other interstitial pulmonary diseases
- Respiratory diseases principally affecting the interstitium, IBD co-morbidites
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 759 | 447 | 310 |
| Only index persons | 620 | 367 | 253 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.31 | 66.49 | 66.17 |
| Only index persons | 66.16 | 66.01 | 66.39 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 193 | 114 | 79 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 65.20 | 64.24 | 66.58 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 197
- Matched controls
- 1970
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
68.1
196.4
126
50
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
52.9
179.0
154
125
L04AX01
ATC
azathioprine; systemic
59.5
156.4
96
31
P01BA02
ATC
hydroxychloroquine; oral
29.8
134.3
119
96
L04AA06
ATC
mycophenolic acid; systemic
91.8
124.8
67
11
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
+∞
123.2
105
*
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
2206.6
121.2
105
*
TGC00
NOMESCO Finland
Bronchial lavation
37.7
98.8
66
26
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
23.0
97.6
85
63
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
35.5
88.9
60
24
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
+∞
85.9
76
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
20.2
82.4
74
57
UGC12
NOMESCO Finland
Flexible bronchoscopy
16.8
81.3
85
85
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
36.0
71.4
47
17
GD1AD
NOMESCO Finland
Thorax CT examination
15.8
65.3
66
61
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
14.2
64.5
71
75
J99.0*M05.1
ICD-10 Finland
Rheumatoid lung disease
+∞
64.1
58
*
L04AX03
ATC
methotrexate; systemic
12.3
63.3
81
106
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
11.2
62.2
90
138
L01BA01
ATC
methotrexate; systemic
23.0
57.7
45
25
XG410
NOMESCO Finland
Flow-volume spirometry
17.8
52.9
47
34
H02AB06
ATC
prednisolone; systemic
27.7
51.5
186
746
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
10.8
49.9
159
551
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
11.5
49.1
60
72
A07EC01
ATC
sulfasalazine; oral, rectal
10.9
47.5
61
78
J18.9
ICD-10 Finland
Pneumonia, unspecified
7.1
42.6
121
360
J99.1*M35.0
ICD-10 Finland
Respiratory disorders in sicca syndrome [Sjögren]
+∞
40.0
37
*
L88
ICPC
Rheumatoid/seropositive arthritis
14.9
39.6
38
31
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
15.5
39.4
37
29
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
38.8
36
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
16.9
38.3
34
24
J99.0
ICD-10 Finland
Rheumatoid lung disease
+∞
34.4
32
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
8.6
34.3
166
756
M05BA04
ATC
alendronic acid; oral
6.9
30.3
57
110
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
51.0
28.8
34
8
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
9.3
27.8
37
48
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
26.7
25
*
M05.1
ICD-10 Finland
Rheumatoid lung disease
+∞
26.7
25
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.8
26.5
101
356
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
6.8
25.7
47
87
ZX120
NOMESCO Finland
Intravenous
6.0
25.5
55
120
J01MA14
ATC
moxifloxacin; systemic
6.2
25.3
52
108
R06.0
ICD-10 Finland
Dyspnoea
4.3
23.1
104
406
L04AA13
ATC
[U] leflunomide
23.0
23.1
33
17
J99.1*M33.2
ICD-10 Finland
Respiratory disorders in polymyositis
+∞
21.2
20
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
9.5
20.6
26
31
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
5.2
20.5
50
120
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
6.7
20.3
36
64
M33.2
ICD-10 Finland
Polymyositis
116.9
20.0
21
*
R50.9
ICD-10 Finland
Fever, unspecified
4.5
19.3
60
175
M31.3
ICD-10 Finland
Wegener granulomatosis
55.3
17.3
20
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
5.3
17.2
39
87
J96.1
ICD-10 Finland
Chronic respiratory failure
20.2
17.0
25
14
J99.1*M34.8
ICD-10 Finland
Respiratory disorders in systemic: sclerosis
+∞
16.9
16
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
6.9
16.9
28
46
TPH04
NOMESCO Finland
Cathetrisation of vein
3.6
15.8
76
296
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
3.9
15.3
55
176
J01MA12
ATC
levofloxacin; systemic
3.6
15.2
66
240
M33.9
ICD-10 Finland
Dermatopolymyositis, unspecified
+∞
14.8
14
*
C03CA01
ATC
furosemide; systemic
3.2
14.4
95
444
R03AK08
ATC
formoterol and beclometasone; inhalant
6.5
14.4
25
43
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
14.2
14.3
24
19
L04AD01
ATC
ciclosporin; systemic
22.1
14.1
20
10
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
13.5
14.0
24
20
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
14.3
13.8
23
18
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
80.9
13.8
15
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.5
13.7
61
224
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
28.1
13.6
18
7
M33.1
ICD-10 Finland
Other dermatomyositis
149.9
13.6
14
*
M05BX04
ATC
denosumab; parenteral
4.9
13.5
33
78
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
30.8
13.2
17
6
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
24.6
13.2
18
8
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.9
13.0
44
134
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.4
12.9
61
232
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.1
12.8
41
120
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.3
12.7
65
259
J99.1*M32.1
ICD-10 Finland
Respiratory disorders in systemic: lupus erythematosus
+∞
12.6
12
*
R81
ICPC
Pneumonia
6.4
12.6
22
38
NH3EA
NOMESCO Finland
Feet X-ray examination with load
14.7
12.2
20
15
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
13.8
11.9
20
16
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
11.6
11
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.5
11.5
46
156
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
4.0
11.5
37
108
L04AA01
ATC
[U] ciclosporin
26.9
11.3
15
6
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
26.9
11.3
15
6
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.0
11.2
35
100
WZC30
NOMESCO Finland
Teaching
3.1
11.2
60
244
H04.10
ICD-10 Finland
Dry eye syndrome
3.5
10.9
44
150
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
63.5
10.7
12
*
GX1K5
NOMESCO Finland
Diffusion capacity
63.5
10.7
12
*
H02AB07
ATC
prednisone; oral
3.4
10.6
45
158
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.0
10.5
60
251
356
Kela drug reimbursment
Nintedanib and pirfenidone
+∞
10.5
10
*
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
25.0
10.4
14
6
M13.9
ICD-10 Finland
Arthritis, unspecified
4.1
10.3
31
86
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
9.7
83
427
R03BA08
ATC
ciclesonide; inhalant
3.6
9.6
35
111
SPAT1229
SPAT
Assessment of need for aid
4.0
9.5
29
81
M01CB01
ATC
sodium aurothiomalate; parenteral
31.8
9.5
12
*
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
31.8
9.5
12
*
L01EX09
ATC
nintedanib; oral
+∞
9.4
9
*
J99.1*M33.9
ICD-10 Finland
Respiratory disorders in dermatopolymyositis
+∞
9.4
9
*
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
+∞
9.4
9
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.5
9.3
114
692
SPAT1255
SPAT
Intravenous administration of medicine
4.3
9.2
25
64
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.3
9.0
25
65
R03AC02
ATC
salbutamol; inhalant
2.6
9.0
132
867
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.2
8.8
40
146
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
8.7
60
275
A02BC02
ATC
pantoprazole; systemic
2.9
8.7
158
1142
M81.4
ICD-10 Finland
Drug-induced osteoporosis
29.0
8.6
11
*
WX726
NOMESCO Finland
High-flow oxygen therapy
+∞
8.4
8
*
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
+∞
8.4
8
*
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
8.4
8
*
R28
ICPC
Limited function/disability (R)
15.3
8.3
13
9
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
12.5
8.2
14
12
ZX108
NOMESCO Finland
Inhalation
34.9
8.2
10
*
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
34.9
8.2
10
*
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
23.2
8.1
11
5
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
11.5
7.9
14
13
B01AA03
ATC
warfarin; systemic
2.7
7.8
51
227
J01AA02
ATC
doxycycline; systemic
3.2
7.7
171
1321
WW200
NOMESCO Finland
Immunization
9.4
7.7
15
17
M34.1
ICD-10 Finland
CR(E)ST syndrome
26.2
7.6
10
*
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
6.5
7.6
19
32
L04AB01
ATC
etanercept; parenteral
14.1
7.5
12
9
M35.1
ICD-10 Finland
Other overlap syndromes
83.1
7.5
8
*
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
83.1
7.5
8
*
Z94.2
ICD-10 Finland
Lung transplant status
83.1
7.5
8
*
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
6.7
7.4
18
29
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
7.3
7
*
GDG10
NOMESCO Finland
Bilateral transplantation of lung
+∞
7.3
7
*
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
+∞
7.3
7
*
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
7.3
7
*
GD1BT
NOMESCO Finland
Biopsy of lung with X-ray guidance
+∞
7.3
7
*
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
7.3
7
*
1XC02, ,
NOMESCO Finland
31.3
7.2
9
*
L01AA01
ATC
cyclophosphamide; systemic
31.3
7.2
9
*
GX2C5
NOMESCO Finland
Short-lasting oximetry
31.3
7.2
9
*
J12.8
ICD-10 Finland
Other viral pneumonia
20.9
7.2
10
5
M05BA07
ATC
risedronic acid; oral
6.8
7.1
17
27
WX892
NOMESCO Finland
Monitored bed care
3.7
7.1
24
72
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.9
6.7
34
131
A02BC01
ATC
omeprazole; systemic
2.3
6.7
69
375
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
12.9
6.7
11
9
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.4
6.6
25
81
J01FA06
ATC
roxithromycin; oral
2.2
6.5
95
594
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
15.0
6.5
10
7
XF622
NOMESCO Finland
Measurement of minute volume of heart
72.1
6.5
7
*
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
72.1
6.5
7
*
L04AK01
ATC
leflunomide; oral
72.1
6.5
7
*
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
72.1
6.5
7
*
J01FF01
ATC
clindamycin; systemic
2.3
6.4
67
367
M10.9
ICD-10 Finland
Gout, unspecified
3.6
6.4
22
67
H02AB04
ATC
methylprednisolone; systemic
2.6
6.3
40
174
J84.0
ICD-10 Finland
Alveolar and parietoalveolar conditions
+∞
6.3
6
*
C02KX04
ATC
macitentan; oral
+∞
6.3
6
*
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
27.6
6.3
8
*
GX1D5
NOMESCO Finland
Flow volume spirometry
27.6
6.3
8
*
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.2
6.3
26
89
NG1DA
NOMESCO Finland
X-ray of knees
8.1
6.2
13
17
SPAT1249
SPAT
Treatment-related counselling outside office
2.1
6.2
88
541
R05
ICD-10 Finland
Cough
2.3
6.2
56
287
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.4
6.2
51
251
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
13.1
6.1
10
8
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
9.0
6.1
12
14
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
3.4
6.1
23
74
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.4
6.1
23
74
I50.9
ICD-10 Finland
Heart failure, unspecified
2.6
6.1
40
177
A03
ICPC
Fever
2.5
6.0
43
198
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
79
48
26.81
99.95
1.7
1.2
54.69
—
u/ml
—
9
0
92
80
20.70
96.92
3.8
1.5
7.85
6.48
iu/ml
0.21
44
20
77
63
19.42
82.99
2.9
1.3
1.23
1.20
g/l
0.27
77
63
68
51
19.83
76.43
1.8
1.2
8.91
1.93
u/ml
—
32
7
68
51
19.83
76.43
1.8
1.2
3.43
1.90
u/ml
—
18
6
50
18
36.89
76.22
2.5
1.6
—
—
—
0
0
64
43
21.56
76.06
1.6
1.1
21.57
—
u/ml
—
12
0
67
66
14.87
63.64
3.6
2.5
—
—
—
0
0
56
55
13.83
52.73
1.8
1.6
0.98
0.09
iu/ml
0.76
17
11
38
22
21.16
47.51
1.6
1.2
48.58
—
u/ml
—
10
0
49
47
13.55
46.56
2.6
1.6
—
—
—
0
0
46
42
13.98
45.02
2.6
1.6
—
—
—
0
0
51
56
11.94
44.19
2.9
1.6
—
—
—
0
0
45
47
12.11
40.17
2.3
1.3
—
—
—
0
0
108
305
6.62
39.69
3.3
2.0
—
—
—
0
0
48
56
11.01
39.64
2.9
1.6
—
—
—
0
0
39
35
13.65
38.33
2.9
1.5
—
—
—
0
0
39
39
12.22
35.67
17.2
5.9
166.80
158.83
iu/ml
—
5
6
107
325
6.02
35.53
1.6
1.3
127.86
36.76
iu/ml
1.75
59
105
36
32
13.54
35.49
2.3
1.7
—
—
—
0
0
37
38
11.76
33.16
2.3
1.7
—
—
—
0
0
98
297
5.58
32.04
1.6
1.3
58.21
11.98
u/ml
2.15
39
113
87
240
5.70
31.68
2.7
1.9
—
—
—
0
0
83
231
5.48
29.65
2.9
2.0
—
—
—
0
0
30
27
12.93
29.15
1.3
1.1
—
—
—
0
0
30
28
12.46
28.47
3.3
1.3
—
—
—
0
0
33
36
10.81
28.20
2.4
1.5
394.29
—
titre
—
7
0
33
36
10.81
28.20
2.4
1.5
96.67
192.00
titre
—
6
5
47
91
6.47
24.56
7.7
3.1
2.30
2.47
mmol/l
0.12
38
68
74
226
4.64
22.83
13.2
8.4
1.25
1.04
mmol/l
0.16
62
197
32
48
7.77
21.10
2.0
1.5
—
—
—
0
0
163
937
5.29
20.02
13.2
7.2
1.21
1.21
mmol/l
0.63
146
805
165
958
5.45
19.99
9.3
4.0
0.00
0.00
estimate
-0.00
54
221
167
979
5.63
19.97
9.3
4.2
0.00
0.00
estimate
-0.00
56
207
188
1329
10.07
19.92
25.1
4.5
21.33
12.23
mm/h
9.07
188
1228
165
967
5.35
19.50
9.3
4.1
0.00
7.19
estimate
0.50
57
226
30
47
7.35
18.97
1.7
1.2
—
—
—
0
0
22
6
40.96
18.03
1.3
1.0
—
—
—
0
0
25
14
20.24
16.98
3.2
2.4
—
—
—
0
0
114
556
3.49
16.73
9.9
4.1
0.00
0.00
estimate
-0.00
55
204
29
25
13.39
16.70
3.6
1.4
—
—
—
0
0
49
144
4.20
15.33
13.0
6.4
9.47
9.58
mmol/l
0.04
49
135
140
823
3.42
14.25
8.4
4.5
32.95
35.69
g/l
6.77
135
773
19
8
26.09
14.08
1.8
1.3
—
—
—
0
0
131
745
3.26
14.02
6.8
4.0
48.26
33.95
ng/l
0.48
117
550
41
117
4.16
13.23
1.6
1.3
238.16
344.66
u/ml
0.27
32
112
24
25
10.77
12.65
1.3
1.2
—
—
—
0
0
49
166
3.60
12.34
2.2
2.4
0.20
0.21
g/l
0.54
43
155
186
1387
7.11
11.97
27.2
8.3
71.54
79.41
u/l
2.97
186
1300
25
53
5.26
11.54
2.8
2.1
—
—
—
0
0
24
50
5.33
11.29
4.0
1.9
124.13
128.65
g/l
0.29
16
40
19
16
13.00
11.10
1.7
1.9
—
—
—
0
0
19
16
13.00
11.10
1.7
1.9
—
—
—
0
0
19
16
13.00
11.10
1.7
1.9
—
—
—
0
0
90
462
2.75
10.81
3.6
2.1
3.94
2.98
mg/l
1.64
84
396
18
15
13.07
10.58
1.1
1.1
—
—
—
0
0
16
10
17.27
10.54
3.4
1.3
—
—
—
0
0
16
11
15.70
10.19
3.4
1.3
—
—
—
0
0
18
17
11.52
10.01
2.2
2.1
—
—
—
0
0
16
12
14.38
9.86
3.4
1.4
—
—
—
0
0
27
71
4.25
9.60
1.2
4.2
63.70
28.33
mg/l
0.65
20
58
27
71
4.25
9.60
1.2
4.2
46.80
44.26
mg/l
0.10
20
58
18
19
10.30
9.49
2.2
1.9
—
—
—
0
0
17
16
11.51
9.49
3.6
1.3
—
—
—
0
0
22
50
4.83
9.35
2.5
1.9
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
53
4.55
8.71
8.0
2.4
0.34
0.40
iu/ml
0.26
11
28
16
16
10.77
8.70
2.9
2.1
280.45
623.18
e6/l
1.34
11
11
18
37
5.25
8.54
11.9
2.9
5.13
4.98
kpa
0.34
18
37
33
109
3.44
8.48
2.1
1.9
—
—
—
0
0
37
132
3.22
8.41
1.7
1.5
—
—
—
0
0
46
187
2.90
8.35
3.8
3.5
2.65
1.98
mmol/l
0.63
41
161
122
789
2.43
8.32
3.8
3.0
170.64
125.93
ug/l
1.63
116
731
19
29
7.13
8.12
1.2
1.2
17.13
1.27
u/ml
—
8
11
11
5
23.16
8.11
1.5
1.0
7.52
11.25
ug/l
—
11
5
115
733
2.37
7.99
10.5
4.0
0.00
0.00
estimate
-0.00
53
185
92
536
2.34
7.84
8.4
3.2
0.40
0.42
e6/l
0.02
84
383
59
283
2.55
7.71
17.9
7.6
104.32
104.08
mmol/l
0.15
59
283
76
410
2.39
7.70
2.8
1.7
1.54
1.55
mg/l
0.01
64
339
13
11
12.55
7.70
1.7
1.7
—
—
—
0
0
13
11
12.55
7.70
1.7
1.7
—
—
—
0
0
13
11
12.55
7.70
1.7
1.7
—
—
—
0
0
13
11
12.55
7.70
1.7
1.7
—
—
—
0
0
16
21
8.19
7.55
1.3
1.2
—
—
—
0
0
16
22
7.81
7.35
1.3
1.2
—
—
—
0
0
23
66
3.81
7.24
1.2
4.0
1.19
2.60
ratio
—
10
34
10
5
20.95
7.21
3.1
1.8
62.55
60.66
ug/l
—
10
5
16
23
7.47
7.16
1.3
1.2
—
—
—
0
0
16
23
7.47
7.16
1.3
1.2
—
—
—
0
0
18
31
6.28
7.11
1.2
1.2
2.38
4.80
u/ml
—
8
15
16
24
7.15
6.97
1.3
1.2
—
—
—
0
0
33
126
2.94
6.63
27.1
8.9
26.08
25.03
mmol/l
0.76
33
126
13
16
8.61
6.44
1.0
1.1
—
—
—
0
0
128
911
2.16
6.11
3.5
2.8
—
—
—
0
0
36
151
2.69
6.07
3.0
2.4
9.38
8.69
ug/l
0.07
31
139
13
18
7.65
6.03
2.5
2.2
87.12
89.41
%
0.71
13
18
37
160
2.62
5.87
2.5
1.4
—
—
—
0
0
16
41
4.16
5.84
1.6
1.5
—
—
—
0
0
71
412
2.13
5.74
1.3
1.3
0.64
1.71
u/ml
1.12
27
113
11
13
8.88
5.64
1.2
1.2
—
—
—
0
0
17
47
3.86
5.62
1.1
1.2
—
—
—
0
0
36
158
2.56
5.53
4.8
2.6
59.80
61.06
ml/min/173m2
0.09
20
64
12
17
7.44
5.53
1.5
1.4
—
—
—
0
0
9
8
11.71
5.34
1.4
1.9
—
—
—
0
0
9
8
11.71
5.34
1.4
1.9
—
—
—
0
0
9
8
11.71
5.34
1.4
1.9
—
—
—
0
0
13
22
6.25
5.32
3.2
4.4
—
—
—
0
0
57
314
2.15
5.20
2.2
1.7
1245.36
1237.08
nmol/l
0.02
52
232
17
52
3.48
4.87
1.5
1.9
—
—
—
0
0
12
21
6.01
4.83
1.6
1.4
—
—
—
0
0
17
55
3.29
4.48
1.4
1.1
—
—
—
0
0
27
114
2.59
4.47
2.7
3.4
24.16
24.52
mmol/l
0.28
27
114
163
1348
2.21
4.36
4.8
4.5
15.47
14.93
pmol/l
1.63
158
1217
23
91
2.73
4.31
1.6
1.2
—
—
—
0
0
11
21
5.48
4.21
1.2
1.3
—
—
—
0
0
65
404
1.91
4.14
1.8
1.8
488.13
453.14
pmol/l
0.40
60
336
38
197
2.15
3.98
5.4
3.2
—
—
—
0
0
8
11
7.52
3.90
4.4
7.3
—
—
—
0
0
16
55
3.08
3.83
1.4
1.1
—
—
—
0
0
79
536
1.79
3.74
9.4
3.6
0.00
0.01
estimate
0.50
54
180
13
36
3.79
3.57
1.6
1.3
112.60
145.93
au/ml
—
5
9
16
59
2.86
3.41
1.3
1.3
—
—
—
0
0
11
28
4.10
3.34
1.2
1.1
—
—
—
0
0
111
849
1.70
3.32
4.1
2.7
—
—
estimate
—
0
0
9
19
4.91
3.28
1.1
1.4
—
—
—
0
0
53
333
1.81
3.17
5.3
2.9
0.53
1.06
e6/l
1.84
42
167
9
20
4.66
3.15
1.0
1.8
—
—
—
0
0
9
20
4.66
3.15
1.0
1.8
—
—
—
0
0
9
20
4.66
3.15
1.0
1.8
—
—
—
0
0
9
20
4.66
3.15
1.0
1.8
—
—
—
0
0
9
20
4.66
3.15
1.0
1.8
—
—
—
0
0
9
21
4.44
3.03
1.0
1.7
—
—
—
0
0
5
5
10.21
2.99
1.0
1.4
—
—
—
0
0
24
116
2.22
2.98
3.8
2.6
1.63
1.26
%
0.83
24
116
12
38
3.30
2.91
1.4
1.2
—
—
—
0
0
12
38
3.30
2.91
1.4
1.2
—
—
—
0
0
14
53
2.77
2.86
1.6
1.4
308.13
258.75
ug/g
—
8
28
23
113
2.17
2.75
3.4
2.6
0.68
0.59
%
0.61
23
113
10
30
3.45
2.64
4.2
2.2
8.58
10.76
mmol/l
—
10
30
18
81
2.35
2.63
1.4
1.2
—
—
—
0
0
5
7
7.29
2.56
1.2
1.7
—
—
—
0
0
5
7
7.29
2.56
1.2
1.7
—
—
—
0
0
5
8
6.38
2.38
1.2
1.7
—
—
—
0
0
5
8
6.38
2.38
1.2
1.7
—
—
—
0
0
5
8
6.38
2.38
1.0
1.1
—
—
—
0
0
56
385
1.64
2.37
2.6
2.7
2.46
2.46
mmol/l
0.06
51
344
13
53
2.56
2.33
1.0
1.4
—
—
—
0
0
59
415
1.60
2.27
12.4
4.1
1.02
1.02
kg/l
0.23
43
280
12
48
2.60
2.23
1.1
1.3
—
—
—
0
0
59
424
1.56
2.06
3.2
2.4
—
—
—
0
0
10
38
2.72
2.03
1.1
1.1
—
—
—
0
0
75
572
1.50
1.98
1.9
1.7
15.53
21.66
nmol/l
3.52
70
471
21
114
1.94
1.96
1.4
1.3
—
32.63
—
0
10
5
11
4.63
1.95
1.4
1.1
13.00
13.55
u/l
—
5
11
159
1424
1.60
1.85
55.9
21.5
14.71
13.73
%
11.49
159
1415
5
12
4.24
1.83
1.0
1.3
0.60
1.14
u/field
—
5
7
42
291
1.56
1.70
5.9
2.0
31.69
29.06
s
2.23
42
282
189
1795
2.30
1.67
39.8
12.6
24.66
24.91
u/l
0.06
189
1737
10
42
2.45
1.64
2.8
3.3
5.49
10.85
pmol/l
—
10
42
186
1752
2.10
1.63
50.4
20.1
139.16
139.74
mmol/l
2.16
186
1719
5
14
3.63
1.62
1.0
1.0
—
—
—
0
0
189
1803
2.19
1.56
61.2
22.3
80.67
77.55
umol/l
0.83
189
1783
186
1756
2.06
1.55
50.6
20.3
3.97
3.98
mmol/l
0.08
186
1719
172
1596
1.61
1.42
6.1
5.6
1.96
1.95
mu/l
0.06
165
1456
5
17
2.99
1.36
1.4
1.3
442.20
284.84
u/l
—
5
17
5
19
2.67
1.22
1.0
1.1
—
—
—
0
0
129
1150
1.35
1.20
5.8
3.3
92.93
47.59
u/l
0.85
119
1076
95
822
1.30
1.04
2.2
2.1
97.29
97.68
pmol/l
0.03
67
387
189
1827
1.85
0.98
73.4
25.6
92.26
91.44
fl
1.29
189
1810
189
1827
1.85
0.98
75.8
26.2
39.59
40.11
%
1.01
189
1810
189
1827
1.85
0.98
74.2
25.8
128.49
134.63
g/l
7.82
189
1809
189
1827
1.85
0.98
73.6
25.6
4.34
4.46
e12/l
2.94
189
1789
189
1826
1.86
0.97
73.6
25.7
263.17
247.37
e9/l
2.54
189
1799
11
62
1.82
0.96
4.5
2.1
1.92
1.52
mg/l
0.65
11
51
8
42
1.94
0.90
2.1
1.6
—
—
—
0
0
10
57
1.79
0.85
2.5
3.6
1.21
1.68
index
—
5
34
29
220
1.37
0.77
5.4
4.9
34.71
32.16
%
0.71
24
134
75
667
1.20
0.57
7.1
4.2
8.78
8.09
mg/mmol
0.09
57
392
37
305
1.26
0.57
7.5
3.0
2.55
2.77
e6/l
0.06
26
142
32
260
1.28
0.56
1.4
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
1.00
—
0
5
0
18
0.00
0.40
0.0
1.1
—
592.85
—
0
13
0
18
0.00
0.40
0.0
1.1
—
38.78
—
0
13
6
44
1.37
0.34
1.0
1.5
—
191.18
—
0
15
163
1675
0.84
0.34
5.7
5.4
5.72
6.02
mmol/l
3.55
151
1533
170
1656
1.19
0.33
6.8
7.0
41.79
39.77
mmol/mol
0.56
165
1552
158
1625
0.86
0.32
5.0
4.5
1.39
1.26
mmol/l
1.87
152
1480
83
776
1.12
0.30
2.1
2.0
1.45
1.32
mmol/l
1.06
73
640
15
180
0.82
0.25
1.8
2.8
36.60
33.81
u/l
0.23
15
144
14
116
1.22
0.22
1.1
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
177.35
—
0
10
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
30
332
0.89
0.20
3.0
3.4
0.64
0.79
ug/l
0.74
19
221
6
50
1.21
0.20
1.5
1.2
—
—
—
0
0
7
62
1.13
0.17
1.0
1.4
—
—
—
0
0
167
1696
0.90
0.16
5.7
5.3
1.44
1.50
mmol/l
1.03
161
1554
22
198
1.13
0.15
10.7
7.8
—
—
—
0
0
12
105
1.15
0.11
1.1
1.9
—
—
—
0
0
55
537
1.03
0.04
4.1
5.8
1.71
2.71
ug/l
0.91
48
477
169
1701
0.95
0.04
5.7
5.5
4.45
4.64
mmol/l
1.55
163
1570
24
246
0.97
0.00
1.8
1.5
—
—
—
0
0
43
428
1.01
0.00
3.6
5.0
23.56
22.69
%
0.16
24
217
0
6
0.00
0.00
0.0
1.0
—
0.31
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
5.86
—
0
5
0
9
0.00
-0.00
0.0
1.4
—
66.04
—
0
9
173
1730
1.00
-0.00
6.2
6.3
2.52
2.69
mmol/l
1.70
165
1594
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.0
—
59.90
—
0
5
8
84
0.95
-0.00
1.4
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint ILD_ELSEWHERE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ILD_ELSEWHERE | 3.489 [2.71, 4.5] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.353 |
During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 355 females with ILD_ELSEWHERE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ILD_ELSEWHERE | 3.206 [2.23, 4.61] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 242 males with ILD_ELSEWHERE died.
Mortality risk
Mortality risk for people of age
years, who have ILD_ELSEWHERE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.286% | 0.576% |
| 5 | 2.039% | 3.501% |
| 10 | 5.545% | 8.929% |
| 15 | 10.315% | 17.278% |
| 20 | 17.819% | 28.56% |
Relationships between endpoints
↥Index endpoint: ILD_ELSEWHERE – ILD and respiratory illness in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data