adult-onset Still's disease: adult-onset Still disease (AOSD) is a rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
173 |
4. Check minimum number of eventsNone |
173 |
5. Include endpointsNone |
173 |
6. Filter based on genotype QC (FinnGen only) |
158 |
Control definitions (FinnGen only)
- Control exclude
- ILD_SYST_AUTO_DISEASES
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Rheumatoid lung disease
based on the number of shared cases.
Similar with more cases:
- Seropositive rheumatoid arthritis
- Polyarthropathies
- Autoimmune diseases related-to ILD
- Autoimmune diseases
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 998 | 519 | 473 |
| Only index persons | 705 | 370 | 335 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 70.83 | 71.81 | 69.83 |
| Only index persons | 70.05 | 70.59 | 69.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 158 | 71 | 87 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 72.85 | 73.60 | 72.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 162
- Matched controls
- 1620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
236.3
240.0
143
50
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
169.0
206.3
146
83
P01BA02
ATC
hydroxychloroquine; oral
63.1
163.2
118
66
A07EC01
ATC
sulfasalazine; oral, rectal
56.7
149.4
101
46
L04AX03
ATC
methotrexate; systemic
44.6
138.0
106
66
J99.0*M05.1
ICD-10 Finland
Rheumatoid lung disease
+∞
127.5
105
*
L04AA13
ATC
[U] leflunomide
72.7
106.3
60
13
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
49.9
105.3
66
22
L01BA01
ATC
methotrexate; systemic
65.7
102.4
59
14
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
45.0
96.7
62
22
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
39.6
92.6
62
25
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
44.5
88.1
56
19
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
27.9
85.6
67
40
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
23.5
82.1
71
52
M05.1
ICD-10 Finland
Rheumatoid lung disease
+∞
76.2
67
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
19.0
70.1
67
58
L88
ICPC
Rheumatoid/seropositive arthritis
31.1
60.2
42
18
J99.0
ICD-10 Finland
Rheumatoid lung disease
+∞
54.3
49
*
H02AB06
ATC
prednisolone; systemic
40.5
50.2
156
633
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
87.6
37.0
40
6
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
81.9
34.8
38
6
TGC00
NOMESCO Finland
Bronchial lavation
14.6
34.5
34
29
L04AX01
ATC
azathioprine; systemic
47.7
33.4
40
11
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.8
30.9
54
98
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.0
30.4
119
459
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
9.0
28.6
41
59
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
80.3
24.7
27
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.9
22.3
101
408
GD1AD
NOMESCO Finland
Thorax CT examination
7.4
21.8
36
60
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
43.8
21.5
26
7
M01CB01
ATC
sodium aurothiomalate; parenteral
38.3
20.9
26
8
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
6.5
20.6
39
75
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
5.2
20.1
54
143
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
5.7
19.4
43
96
L04AB01
ATC
etanercept; parenteral
201.1
17.9
18
*
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
47.9
17.8
21
5
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
45.2
16.8
20
5
M05BA04
ATC
alendronic acid; oral
5.2
16.4
40
96
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
6.7
15.0
26
45
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.1
14.9
121
674
R06.0
ICD-10 Finland
Dyspnoea
3.5
14.1
82
365
L04AB04
ATC
adalimumab; parenteral
58.7
14.1
16
*
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
152.2
13.7
14
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
12.0
13.3
24
23
L04AA06
ATC
mycophenolic acid; systemic
25.1
13.2
18
8
ZX120
NOMESCO Finland
Intravenous
4.4
13.0
38
105
L04AA01
ATC
[U] ciclosporin
35.2
12.8
16
5
M01CB03
ATC
auranofin; oral
50.7
12.1
14
*
H02AB07
ATC
prednisone; oral
3.9
11.9
43
138
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
20.9
11.9
17
9
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
9.2
11.6
24
30
M13.9
ICD-10 Finland
Arthritis, unspecified
4.9
11.3
27
63
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
17.1
11.1
17
11
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
17.1
11.1
17
11
NH3EA
NOMESCO Finland
Feet X-ray examination with load
19.5
11.0
16
9
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
23.4
10.9
15
7
L04AK01
ATC
leflunomide; oral
117.3
10.5
11
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.4
10.5
29
76
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.1
10.1
23
51
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
13.4
10.1
17
14
Z01.8
ICD-10 Finland
Other specified special examinations
3.2
9.9
51
204
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
58.6
9.8
11
*
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
58.6
9.8
11
*
J01MA14
ATC
moxifloxacin; systemic
3.8
9.7
34
106
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
8.3
9.3
20
27
NDL52
NOMESCO Finland
Tenosynovectomy of hand
20.0
9.1
13
7
R50.9
ICD-10 Finland
Fever, unspecified
3.2
8.9
43
164
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
9.1
8.9
18
22
GX1K5
NOMESCO Finland
Diffusion capacity
52.9
8.8
10
*
L04AA24
ATC
abatacept; parenteral
52.9
8.8
10
*
L04AD01
ATC
ciclosporin; systemic
29.3
8.6
11
*
XG410
NOMESCO Finland
Flow-volume spirometry
7.0
8.3
20
32
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.5
8.3
32
106
N03AX12
ATC
[U] gabapentin; oral
3.1
8.2
42
166
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
23.4
8.1
11
5
NHM20
NOMESCO Finland
Excision of synovial ganglion of ankle or foot
26.4
7.7
10
*
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
14.3
7.5
12
9
L01EX09
ATC
nintedanib; oral
83.8
7.5
8
*
M01AC06
ATC
meloxicam; systemic, rectal
2.5
7.4
76
425
TNC11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in elbow joint
+∞
7.3
7
*
L01CB
ATC
Podophyllotoxin derivatives
+∞
7.3
7
*
291
Kela drug reimbursment
Tofacitinib
+∞
7.3
7
*
A03
ICPC
Fever
3.1
7.2
34
127
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
31.6
7.2
9
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.7
7.2
49
224
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
12.8
7.2
12
10
NG1DA
NOMESCO Finland
X-ray of knees
10.8
7.2
13
13
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.9
7.2
17
27
R81
ICPC
Pneumonia
6.4
7.2
18
31
H02AB04
ATC
methylprednisolone; systemic
3.0
7.0
36
141
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.0
7.0
21
58
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
4.0
7.0
21
58
ZYC01
NOMESCO Finland
Remote contact by phone
4.3
6.9
19
49
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
7.8
6.9
15
21
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.2
6.9
30
107
SPAT1255
SPAT
Intravenous administration of medicine
3.8
6.5
21
61
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
72.6
6.5
7
*
M05.3
ICD-10 Finland
Rheumatoid arthritis with involvement of other organs and systems
72.6
6.5
7
*
SPAT1229
SPAT
Assessment of need for aid
3.3
6.5
26
88
M06
ICD-10 Finland
Other rheumatoid arthritis
18.9
6.3
9
5
N02AX02
ATC
tramadol; systemic, rectal
2.3
6.3
86
534
356
Kela drug reimbursment
Nintedanib and pirfenidone
27.9
6.3
8
*
ZX140
NOMESCO Finland
Intra articular
27.9
6.3
8
*
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
27.9
6.3
8
*
L40.5
ICD-10 Finland
Arthropathic psoriasis
+∞
6.3
6
*
NCB20
NOMESCO Finland
Primary total prosthetic replacement of elbow joint
+∞
6.3
6
*
J990, M058,
ICD-10 Finland
+∞
6.3
6
*
L04AA17
ATC
[U] adalimumab
+∞
6.3
6
*
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
5.8
6.0
16
30
R03AK08
ATC
formoterol and beclometasone; inhalant
6.2
6.0
15
26
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
48
30
22.32
58.83
1.8
1.5
0.18
0.05
iu/ml
—
13
7
43
44
12.94
39.21
1.4
1.4
2.22
4.80
iu/ml
—
10
10
74
216
5.47
25.17
1.7
1.3
121.92
17.76
u/ml
5.45
34
70
42
72
7.53
24.99
3.2
3.2
—
—
—
0
0
75
235
5.08
23.12
1.5
1.3
179.06
42.40
iu/ml
2.47
54
77
32
45
8.62
22.51
1.7
1.2
—
—
—
0
0
29
51
6.71
16.53
2.2
1.7
—
—
—
0
0
26
41
7.36
16.38
2.1
1.4
18387.24
3956.60
e6/l
0.56
21
30
25
42
6.86
14.82
1.6
1.7
—
—
—
0
0
28
53
6.18
14.78
2.8
1.7
—
—
—
0
0
23
16
16.53
14.57
1.5
1.4
—
—
—
0
0
69
277
3.60
13.93
3.0
2.0
—
—
—
0
0
34
85
4.80
13.15
2.5
1.9
2.25
4.66
ug/l
0.31
34
76
22
37
6.72
12.97
1.7
1.7
—
—
—
0
0
22
38
6.54
12.64
1.6
1.8
—
—
—
0
0
21
36
6.55
12.14
3.1
1.9
—
—
—
0
0
55
207
3.51
12.03
2.2
1.8
—
—
—
0
0
52
199
3.38
10.96
2.3
2.0
—
—
—
0
0
21
29
8.15
9.58
1.2
1.2
—
—
—
0
0
18
20
9.97
9.31
2.4
1.6
—
—
—
0
0
18
20
9.97
9.31
2.4
1.6
—
—
—
0
0
18
20
9.97
9.31
2.4
1.6
—
—
—
0
0
21
33
7.15
8.84
1.6
1.8
—
—
—
0
0
21
49
4.78
8.69
1.4
1.5
—
—
—
0
0
83
457
2.67
8.68
9.8
4.2
0.00
0.01
estimate
0.50
28
152
17
20
9.35
8.55
3.2
1.6
—
—
—
0
0
100
611
2.66
8.35
3.1
2.5
83.69
80.57
nmol/l
0.44
94
535
40
154
3.12
8.14
1.8
2.4
64.98
65.35
g/l
0.10
35
139
33
113
3.41
8.12
5.6
3.2
55.67
57.38
ml/min/173m2
0.13
18
45
16
20
8.75
7.81
3.3
1.6
—
—
—
0
0
101
648
2.48
7.20
5.3
4.4
49.72
34.83
ng/l
0.46
91
506
118
819
2.62
7.02
7.2
7.7
1.21
1.21
mmol/l
0.12
105
699
115
796
2.53
6.75
9.1
4.3
0.00
1.81
estimate
0.50
30
166
16
26
6.71
6.66
1.8
1.9
—
—
—
0
0
15
24
6.77
6.33
1.0
1.3
—
—
—
0
0
113
789
2.43
6.30
9.1
4.2
0.00
9.12
estimate
0.50
30
178
112
781
2.41
6.23
9.1
4.2
0.00
0.00
estimate
-0.00
29
168
27
96
3.17
6.20
5.4
3.9
3.05
2.43
mmol/l
0.48
19
72
18
50
3.92
5.95
1.3
1.5
—
—
—
0
0
59
334
2.21
5.22
11.1
4.4
1.02
1.02
kg/l
0.95
42
228
98
702
2.00
4.39
4.4
4.8
31.89
34.56
g/l
3.94
92
657
7
7
10.38
4.05
1.1
1.0
—
—
—
0
0
63
402
1.93
3.83
3.0
3.2
356.39
355.62
umol/l
0.02
57
347
47
272
2.03
3.77
4.1
3.1
0.87
0.98
e6/l
0.15
34
145
85
603
1.86
3.69
10.1
4.2
0.00
0.04
estimate
0.78
29
140
22
93
2.58
3.67
1.5
2.1
1.98
1.63
g/l
0.60
17
82
6
6
10.32
3.52
2.0
1.2
—
—
—
0
0
22
95
2.52
3.52
4.4
2.6
1.65
1.15
%
1.36
22
95
88
639
1.83
3.48
3.0
2.4
—
—
—
0
0
7
11
6.59
3.22
3.9
1.5
—
—
—
0
0
7
11
6.59
3.22
3.9
1.5
—
—
—
0
0
7
11
6.59
3.22
3.9
1.5
—
—
—
0
0
7
11
6.59
3.22
3.9
1.5
—
—
—
0
0
21
93
2.45
3.19
4.1
2.6
0.70
0.65
%
0.21
21
93
21
95
2.39
3.05
2.8
1.7
—
—
—
0
0
9
22
4.27
2.93
1.8
1.9
—
—
—
0
0
15
59
2.70
2.88
4.1
1.9
—
—
—
0
0
10
28
3.74
2.83
1.0
1.1
—
—
—
0
0
66
462
1.72
2.80
4.9
3.3
0.45
0.46
e6/l
0.01
56
340
74
535
1.71
2.79
2.6
3.5
2.32
2.35
mmol/l
1.10
69
478
52
341
1.77
2.76
2.5
1.7
2.35
1.64
mg/l
0.37
40
283
14
56
2.64
2.61
2.7
1.7
—
—
—
0
0
9
26
3.60
2.52
3.0
2.2
7.87
10.30
mmol/l
—
9
26
18
83
2.31
2.52
1.7
1.2
175.83
216.46
u/ml
0.12
18
74
78
584
1.65
2.50
3.4
3.1
355.51
154.53
ug/l
0.78
73
535
18
84
2.29
2.45
1.8
1.4
—
—
—
0
0
8
23
3.60
2.30
3.7
4.0
—
—
—
0
0
12
48
2.62
2.24
1.8
1.8
—
—
—
0
0
22
116
2.04
2.24
1.6
1.7
—
—
—
0
0
5
9
5.69
2.23
4.8
1.6
—
—
—
0
0
5
9
5.69
2.23
4.8
1.6
—
—
—
0
0
5
9
5.69
2.23
4.8
1.6
—
—
—
0
0
13
58
2.35
1.96
1.4
1.3
—
—
—
0
0
5
11
4.65
1.95
1.6
2.1
—
—
—
0
0
5
11
4.65
1.95
1.6
2.2
—
—
—
0
0
28
171
1.77
1.86
13.1
8.5
—
—
—
0
0
5
137
0.34
1.85
1.0
1.2
—
—
—
0
0
5
12
4.26
1.83
1.0
1.2
—
—
—
0
0
0
46
0.00
1.74
0.0
2.2
—
3.20
—
0
35
6
19
3.24
1.67
1.0
1.2
—
—
—
0
0
5
14
3.65
1.62
1.6
2.0
—
—
—
0
0
5
14
3.65
1.62
2.0
1.7
11.60
12.57
u/l
—
5
14
5
14
3.65
1.62
1.2
1.2
—
—
—
0
0
43
307
1.55
1.57
1.8
1.8
1583.31
1240.70
nmol/l
0.63
36
220
5
15
3.40
1.53
2.0
2.1
—
—
—
0
0
9
38
2.45
1.48
1.2
1.4
—
—
—
0
0
13
66
2.05
1.48
1.5
3.7
1.41
4.66
ratio
—
8
31
21
127
1.75
1.45
1.3
1.4
—
—
—
0
0
7
29
2.48
1.41
1.3
1.5
—
—
—
0
0
5
17
3.00
1.37
1.2
1.2
—
—
—
0
0
5
17
3.00
1.37
1.4
1.2
39.00
11.47
u/l
—
5
17
27
179
1.61
1.35
4.1
3.8
5.71
5.73
kpa
0.04
27
174
48
365
1.45
1.28
1.4
2.0
603.25
438.81
pmol/l
1.86
40
298
22
140
1.66
1.28
3.2
4.6
1.22
1.22
mmol/l
0.09
22
119
80
674
1.37
1.17
4.4
2.9
—
—
estimate
—
0
0
0
35
0.00
1.16
0.0
2.0
—
2.20
—
0
27
9
46
2.01
1.05
1.6
1.1
—
—
—
0
0
5
22
2.31
1.04
1.4
1.2
—
—
—
0
0
9
47
1.97
1.04
1.6
1.1
—
—
—
0
0
6
27
2.27
0.94
1.5
1.5
—
—
—
0
0
6
27
2.27
0.94
1.5
1.5
—
—
—
0
0
26
346
0.70
0.86
3.5
3.6
0.59
0.82
ug/l
1.49
20
244
47
563
0.77
0.78
3.3
4.1
3.71
7.53
mg/mmol
1.71
39
363
23
169
1.42
0.74
4.5
3.9
—
—
—
0
0
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
13
90
1.48
0.57
2.7
5.1
1.56
1.48
%
0.18
13
85
9
62
1.48
0.54
1.6
1.2
—
—
—
0
0
7
47
1.51
0.48
1.0
1.6
—
—
—
0
0
7
51
1.39
0.44
1.0
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
1.08
—
0
5
0
17
0.00
0.41
0.0
1.1
—
598.00
—
0
12
0
17
0.00
0.41
0.0
1.1
—
38.84
—
0
12
52
578
0.85
0.39
4.8
6.1
2.10
2.84
ug/l
0.59
47
508
39
340
1.19
0.38
3.9
2.5
—
—
—
0
0
142
1381
1.23
0.32
59.6
29.5
93.37
91.77
fl
2.63
142
1365
142
1382
1.22
0.31
59.9
30.0
39.57
39.54
%
0.03
142
1366
142
1382
1.22
0.31
60.2
29.7
128.46
132.52
g/l
2.89
142
1365
32
284
1.16
0.26
1.3
1.2
0.72
2.03
u/ml
—
10
77
11
87
1.28
0.25
4.9
4.9
1.02
1.02
ratio
0.15
11
81
42
458
0.89
0.23
4.1
5.0
20.82
21.92
%
0.19
25
248
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
57.85
—
0
10
0
10
0.00
0.21
0.0
4.6
—
222.80
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
123
1202
1.10
0.16
5.5
5.5
2.10
2.04
mu/l
0.19
117
1060
17
151
1.14
0.14
1.1
1.4
—
—
—
0
0
11
94
1.18
0.13
1.3
3.4
24.45
23.93
mmol/l
0.32
11
94
42
443
0.93
0.11
8.0
3.8
0.00
0.18
estimate
0.50
26
139
5
46
1.09
0.09
1.0
1.3
—
—
—
0
0
124
1258
0.94
0.08
5.1
5.5
1.44
1.46
mmol/l
0.26
118
1131
125
1261
0.96
0.04
5.2
5.6
4.27
4.46
mmol/l
1.25
118
1142
70
688
1.03
0.04
2.2
2.2
87.54
96.10
pmol/l
1.08
43
344
79
801
0.97
0.03
4.7
3.3
77.55
55.71
u/l
0.46
71
738
119
1200
0.97
0.03
4.7
4.7
1.40
1.25
mmol/l
1.53
113
1069
27
261
1.04
0.03
4.3
3.3
7.89
2.62
e6/l
0.40
14
138
51
506
1.01
0.00
1.8
1.8
18.56
21.23
nmol/l
0.61
46
404
129
1289
1.00
0.00
5.8
6.6
2.40
2.54
mmol/l
0.91
124
1168
127
1272
0.99
0.00
5.2
5.9
6.00
6.10
mmol/l
0.38
115
1145
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
10.20
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
0.00
1.5
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.33
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
96.50
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint RHEUMAT_LUNG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMAT_LUNG | 4.335 [3.39, 5.55] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.19 |
During the follow-up period (1.1.1998 — 31.12.2019), 221 out of 379 females with RHEUMAT_LUNG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMAT_LUNG | 3.125 [2.41, 4.05] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 209 out of 351 males with RHEUMAT_LUNG died.
Mortality risk
Mortality risk for people of age
years, who have RHEUMAT_LUNG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.334% | 0.578% |
| 5 | 2.191% | 3.843% |
| 10 | 5.284% | 9.686% |
| 15 | 10.592% | 17.551% |
| 20 | 19.317% | 28.326% |
Relationships between endpoints
↥Index endpoint: RHEUMAT_LUNG – Rheumatoid lung disease
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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