This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Operations 1 for CAVS
I9_CAVS_OPERATIONS1
No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
120 |
4. Check minimum number of eventsNone |
120 |
5. Include endpointsNone |
120 |
6. Filter based on genotype QC (FinnGen only) |
105 |
Control definitions (FinnGen only)
- Control exclude
- I9_CAVS
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Operations 1 for CAVS
based on the number of shared cases.
Similar with more cases:
- Valvular operations
- Calcific aortic valvular stenosis, operated
- Calcific aortic valvular stenosis
- Valvular heart disease excluding rheumatic fever
- Other heart diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 105 | 52 | 53 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 61.12 | 62.00 | 60.26 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 108
- Matched controls
- 1080
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
74.8
109.7
68
24
I35.0
ICD-10 Finland
Aortic (valve) stenosis
1619.3
99.9
82
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
38.8
81.2
61
35
B01AA03
ATC
warfarin; systemic
37.5
80.1
85
97
WX872
NOMESCO Finland
Intensive care
49.3
72.4
46
16
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
17.1
51.1
74
122
FMB10
NOMESCO Finland
Transannular expansion of aortic ostium
+∞
49.9
44
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
273.5
49.5
47
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
15.3
45.6
77
151
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
325.4
43.3
41
*
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
23.1
42.9
35
22
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
+∞
42.5
38
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
11.5
37.3
71
154
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
11.0
36.3
63
122
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
471.8
35.0
33
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.4
29.7
38
49
ZXE30
NOMESCO Finland
More than five and less than seven hours
13.7
26.5
28
27
GD1AA
NOMESCO Finland
Thorax X-ray examination
10.9
23.5
92
374
Q23.11
ICD-10 Finland
Bicuspid aortic valve
101.5
22.7
24
*
C07AB07
ATC
bisoprolol; oral
8.3
20.8
87
361
TPH07
NOMESCO Finland
Cathetrisation of artery
7.0
18.4
35
69
K83
ICPC
Heart valve disease NOS
80.8
18.4
20
*
FMB00
NOMESCO Finland
Supravalvular aortic expansion using patch
+∞
17.1
16
*
FMA20
NOMESCO Finland
Plastic repair of aortic valve for stenosis
+∞
16.0
15
*
C03CA01
ATC
furosemide; systemic
4.9
15.2
63
240
ZXD10
NOMESCO Finland
Scheduled procedure
4.9
15.0
69
285
FMB96
NOMESCO Finland
Other expansion of aortic ostium
+∞
14.9
14
*
XF402
NOMESCO Finland
ECG with work load test
6.9
14.1
25
45
FMA32
NOMESCO Finland
Percutaneous transluminal expansion of aortic valve
+∞
13.8
13
*
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
159.2
13.8
14
*
XF600
NOMESCO Finland
Bloodpressure measurement
7.2
13.7
23
39
ZXE20
NOMESCO Finland
More than three and less than five hours
5.2
13.2
34
87
AN1
HP
Coronary angiography
5.7
13.1
29
65
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
6.3
12.9
25
49
AB2
HP
AVR bio, stent
+∞
12.7
12
*
XF404
NOMESCO Finland
Ambulatory ECG
6.1
12.1
24
48
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
+∞
11.7
11
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.1
11.6
51
195
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
39.8
11.6
14
*
B01AB05
ATC
enoxaparin; parenteral
4.0
11.3
52
205
ZXD05
NOMESCO Finland
Urgent procedure
4.0
11.2
51
199
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
24.5
11.0
15
7
AP6
HP
Valveoplasty of the aortic valve
+∞
10.6
10
*
PD5AD
NOMESCO Finland
CT of aorta
16.8
10.4
16
11
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
6.1
10.3
20
39
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
9.4
10.2
21
27
FNC10
NOMESCO Finland
Aorto-coronary venous bypass with single distal anastomosis
60.6
9.8
11
*
Q25.1
ICD-10 Finland
Coarctation of aorta
60.6
9.8
11
*
XF400
NOMESCO Finland
ECG with 12 standard connections
4.1
9.6
34
110
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
13.2
9.4
16
14
ZXE40
NOMESCO Finland
More than seven and less than nine hours
14.3
9.2
15
12
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
9.0
9.1
19
25
201
Kela drug reimbursment
Chronic cardiac insufficiency
8.6
8.9
19
26
WX402
NOMESCO Finland
General anaesthesia
3.5
8.6
42
167
ZXE00
NOMESCO Finland
One hour or less
3.2
8.2
57
280
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
48.6
7.8
9
*
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
13.2
7.8
13
11
I50.9
ICD-10 Finland
Heart failure, unspecified
3.6
7.8
32
113
G45.3
ICD-10 Finland
Amaurosis fugax
20.2
7.8
11
6
C03DA01
ATC
spironolactone; oral
4.0
7.7
25
75
Q25.3
ICD-10 Finland
Stenosis of aorta
85.7
7.5
8
*
Z95.3
ICD-10 Finland
Presence of xenogenic heart valve
85.7
7.5
8
*
FMD22
NOMESCO Finland
Percutaneous transluminal replacement of aortic valve using biological prosthesis
+∞
7.4
7
*
WX892
NOMESCO Finland
Monitored bed care
4.8
7.3
18
43
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
21.8
7.3
10
5
AA1AD
NOMESCO Finland
CT of head and brain
3.1
7.2
43
190
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
12.1
7.0
12
11
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
24.3
6.8
9
*
K99
ICPC
Cardiovascular disease other
24.3
6.8
9
*
R4110
NOMESCO Finland
Physiotherapy
2.9
6.7
46
218
I44.2
ICD-10 Finland
Atrioventricular block, complete
12.1
6.5
11
10
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
19.4
6.4
9
5
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
28.5
6.3
8
*
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
+∞
6.3
6
*
FC1BC
NOMESCO Finland
Extensive angiography of thoracal aortta
+∞
6.3
6
*
FMD40
NOMESCO Finland
Replacement of aortic root using pulmonary autograft and reimplantation of coronary arteries (Ross)
+∞
6.3
6
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
6.8
6.3
15
25
FM2CE, ,
NOMESCO Finland
9.5
6.2
12
14
WX002
NOMESCO Finland
Sedation and analgesia
3.3
6.2
27
98
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
28
10.12
11.55
34.0
8.6
0.30
0.38
iu/ml
0.54
16
17
56
230
3.98
11.48
3.4
3.0
—
—
—
0
0
25
59
5.21
10.50
29.4
6.7
77.96
89.32
%
1.75
25
59
35
118
3.91
9.26
16.1
19.0
24.23
24.56
mmol/l
0.25
35
118
73
404
3.49
8.70
3.8
3.2
—
—
estimate
—
0
0
32
111
3.68
8.02
15.5
13.4
6.64
8.19
mmol/l
0.84
32
104
14
22
7.14
6.09
1.6
1.6
—
—
—
0
0
32
142
2.78
5.12
13.2
11.4
107.47
104.25
mmol/l
2.69
32
142
11
21
5.70
4.27
1.0
1.6
—
—
—
0
0
57
364
2.20
3.92
4.8
3.8
235.79
37.85
ng/l
1.94
42
259
37
206
2.21
3.51
8.5
3.0
1.94
1.58
mg/l
0.14
28
173
11
29
4.10
3.29
1.8
2.4
—
—
—
0
0
11
29
4.10
3.29
1.7
2.0
—
—
—
0
0
29
157
2.16
2.89
1.9
2.0
—
—
—
0
0
48
315
1.94
2.83
3.9
4.0
32.63
32.69
u/l
0.01
48
301
11
34
3.48
2.82
3.5
15.6
59.36
67.56
%
0.49
11
34
6
10
6.28
2.73
6.3
7.8
86.00
95.10
%
—
6
10
23
118
2.21
2.60
12.5
11.4
5.07
5.00
kpa
0.36
23
113
5
7
7.42
2.57
5.8
4.1
6.24
6.19
kpa
—
5
7
18
84
2.37
2.52
12.3
12.0
24.82
24.41
mmol/l
0.42
18
79
7
16
4.60
2.52
1.3
1.8
—
—
—
0
0
14
58
2.62
2.49
1.4
1.8
—
—
—
0
0
63
472
1.80
2.31
14.8
10.9
1.18
1.21
mmol/l
2.72
55
408
38
245
1.85
2.28
2.7
3.1
2.73
3.05
mg/l
0.38
32
212
27
161
1.90
2.03
20.0
10.9
1.20
1.17
mmol/l
0.24
27
151
9
33
2.88
1.98
1.6
2.0
—
—
—
0
0
15
75
2.16
1.80
4.5
8.7
121.53
124.05
g/l
0.13
15
75
9
36
2.63
1.78
1.6
2.1
—
—
—
0
0
26
160
1.82
1.77
5.4
9.8
1.14
1.28
mmol/l
0.07
21
131
7
26
2.81
1.61
1.0
1.2
—
—
—
0
0
13
66
2.10
1.51
3.4
10.5
0.79
0.62
%
1.07
13
66
20
122
1.78
1.39
1.7
1.8
—
—
—
0
0
25
163
1.69
1.39
5.4
9.7
5.88
5.67
kpa
0.42
25
158
13
69
2.01
1.35
3.4
10.1
1.22
1.35
%
0.21
13
69
6
25
2.48
1.26
1.3
1.7
—
—
—
0
0
19
118
1.74
1.25
1.8
1.9
—
—
—
0
0
5
19
2.71
1.23
1.2
1.9
—
—
—
0
0
5
20
2.57
1.16
1.0
1.9
—
—
—
0
0
5
20
2.57
1.16
1.2
2.0
—
—
—
0
0
64
536
1.48
1.15
10.7
13.8
4.36
3.93
e9/l
0.99
57
463
18
115
1.68
1.08
1.7
2.5
368.67
347.36
nmol/l
0.16
18
109
9
46
2.04
1.07
4.8
4.0
25.70
24.70
mmol/l
—
9
46
51
414
1.44
1.05
4.4
3.4
131.68
114.87
ug/l
0.25
46
376
22
151
1.57
1.01
5.4
9.9
4.88
4.67
kpa
0.25
22
146
6
27
2.29
0.95
1.0
2.1
—
—
—
0
0
13
79
1.73
0.93
4.3
3.9
—
—
—
0
0
6
32
1.93
0.83
1.8
2.6
—
—
—
0
0
0
24
0.00
0.80
0.0
1.5
—
—
—
0
0
35
279
1.38
0.76
4.1
4.2
7.81
6.52
mg/mmol
0.11
23
185
12
77
1.63
0.72
1.2
1.3
93.75
693.72
u/ml
0.97
12
69
7
41
1.76
0.71
2.7
1.8
1.92
0.43
ug/l
—
7
35
82
757
1.35
0.61
23.1
16.9
79.62
80.05
ml/min/173m2
0.06
77
690
10
64
1.62
0.61
13.6
5.1
1.20
1.22
mmol/l
—
10
56
6
35
1.76
0.59
1.8
1.3
—
—
—
0
0
10
68
1.52
0.49
2.4
1.6
—
—
—
0
0
34
290
1.25
0.44
3.2
3.0
58.12
75.16
u/l
0.49
34
268
6
93
0.62
0.44
2.5
1.5
—
—
—
0
0
11
79
1.44
0.42
1.7
3.2
63.12
66.25
g/l
0.74
11
74
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
5
34
1.49
0.41
1.2
2.4
—
—
—
0
0
28
240
1.23
0.35
3.3
4.9
0.00
0.00
estimate
—
9
81
42
376
1.19
0.34
1.7
2.1
102.80
91.63
pmol/l
0.85
26
182
13
101
1.33
0.33
3.1
4.3
0.20
0.21
g/l
0.20
13
96
85
811
1.23
0.32
4.6
5.2
1.88
1.99
mu/l
0.38
80
731
8
110
0.71
0.30
16.8
7.9
—
—
—
0
0
9
73
1.25
0.26
4.4
7.5
47.89
75.83
ng/l
—
9
66
16
190
0.81
0.26
3.6
4.0
1.12
0.89
e6/l
—
5
118
31
344
0.86
0.24
4.6
4.4
0.18
0.00
estimate
0.47
11
76
5
37
1.37
0.24
1.4
4.7
13.60
1823.06
u/ml
—
5
32
5
40
1.26
0.23
1.0
1.3
—
—
—
0
0
95
925
1.22
0.22
33.4
21.9
83.44
74.26
umol/l
0.62
95
911
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
3.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
43.26
—
0
12
0
13
0.00
0.21
0.0
2.4
—
—
—
0
0
61
578
1.13
0.20
3.1
3.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
50
469
1.12
0.20
4.2
4.5
0.00
0.00
estimate
-0.00
13
87
77
797
0.88
0.18
5.5
5.0
5.83
5.96
mmol/l
0.62
72
727
5
67
0.73
0.17
1.0
1.5
—
—
—
0
0
50
477
1.09
0.13
4.2
4.5
0.00
3.61
estimate
0.49
13
83
22
239
0.90
0.12
4.5
4.3
30.93
22.90
%
—
9
113
49
469
1.08
0.11
4.3
4.5
0.00
0.00
estimate
-0.00
13
90
17
187
0.89
0.11
4.0
2.9
1.17
0.83
ug/l
—
10
109
14
126
1.13
0.09
1.7
1.3
1.42
6.93
u/ml
—
5
42
7
65
1.08
0.08
8.4
4.3
46.80
51.02
%
—
7
65
27
284
0.93
0.07
3.9
4.5
0.07
0.28
e6/l
1.87
17
211
20
188
1.08
0.06
1.6
1.9
—
—
—
0
0
11
101
1.10
0.04
8.8
5.3
33.00
32.75
%
0.03
11
57
25
252
0.99
0.00
4.7
3.8
0.00
0.35
estimate
—
10
72
33
329
1.00
0.00
2.3
2.2
1.33
1.37
mmol/l
0.11
25
280
25
253
0.98
0.00
1.6
1.7
18.96
21.02
nmol/l
0.30
25
208
78
777
1.01
0.00
5.9
4.5
1.38
1.29
mmol/l
0.65
73
708
24
236
1.02
0.00
1.1
1.6
1.23
2.21
u/ml
—
6
60
17
171
0.99
0.00
3.4
4.2
1.02
1.72
e6/l
—
5
102
15
149
1.01
0.00
1.6
1.2
12.48
33.60
iu/ml
—
5
46
0
7
0.00
0.00
0.0
6.3
—
1.57
—
0
7
0
7
0.00
0.00
0.0
3.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
16.20
—
0
5
9
94
0.95
-0.00
2.2
2.3
13.52
14.20
nmol/l
—
9
88
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
41.44
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.5
—
4.48
—
0
8
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1667.67
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.5
—
9.77
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
1.15
—
0
6
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
320.10
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
71.40
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
93.20
—
0
5
0
9
0.00
-0.00
0.0
7.1
—
185.19
—
0
9
0
5
0.00
-0.00
0.0
9.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: I9_CAVS_OPERATIONS1 – Operations 1 for CAVS
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).