No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
191 |
4. Check minimum number of eventsNone |
191 |
5. Include endpointsNone |
191 |
6. Filter based on genotype QC (FinnGen only) |
167 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Similar endpoints
↥List of similar endpoints to
Congenital aortic valve stenosis
based on the number of shared cases.
Similar with more cases:
- Left ventricular outflow tract obstruction, narrow definition
- Congenital malformations of heart and great arteries
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities, including avohilmo
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 167 | 59 | 108 |
| Unadjusted period prevalence (%) | 0.04 | 0.02 | 0.05 |
| Median age at first event (years) | 12.37 | 10.67 | 13.31 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 180
- Matched controls
- 1800
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
+∞
173.0
137
*
I35.0
ICD-10 Finland
Aortic (valve) stenosis
77.8
132.0
74
16
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
72.1
115.3
65
14
Q23.11
ICD-10 Finland
Bicuspid aortic valve
606.2
100.9
91
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
33.1
97.6
70
34
B01AA03
ATC
warfarin; systemic
23.1
96.2
87
70
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
25.6
92.8
76
50
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
18.9
92.2
122
180
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
17.3
84.2
95
109
201
Kela drug reimbursment
Chronic cardiac insufficiency
41.5
80.0
51
17
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
176.4
50.8
51
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
137.2
48.7
50
5
7463A
ICD-9 Finland
Other congenital anomalies of heart, Congenital stenosis of aortic valve[STENOSIS VALVULAE AORTAE CONGENITA]
+∞
43.5
40
*
XF402
NOMESCO Finland
ECG with work load test
13.8
41.6
43
40
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.6
41.1
53
68
C03CA01
ATC
furosemide; systemic
8.4
39.8
68
122
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
239.0
38.4
38
*
Q25.1
ICD-10 Finland
Coarctation of aorta
164.7
38.4
39
*
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
18.1
38.4
33
22
XF400
NOMESCO Finland
ECG with 12 standard connections
7.5
37.8
75
157
WX872
NOMESCO Finland
Intensive care
15.4
34.1
32
25
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
50.9
33.8
40
10
XF404
NOMESCO Finland
Ambulatory ECG
10.8
33.7
41
48
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.8
32.9
70
155
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
185.9
30.7
31
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
8.4
28.6
43
65
C07AB07
ATC
bisoprolol; oral
5.4
28.0
90
283
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.3
27.3
115
448
B01AB05
ATC
enoxaparin; parenteral
5.5
26.0
69
183
XF600
NOMESCO Finland
Bloodpressure measurement
7.0
25.7
46
84
TPH07
NOMESCO Finland
Cathetrisation of artery
6.8
25.5
48
92
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
7.0
25.1
45
82
XFE00
NOMESCO Finland
Epicardial ultrasonography
42.8
23.8
29
8
ZXE20
NOMESCO Finland
More than three and less than five hours
6.0
23.7
51
111
7463D
ICD-9 Finland
Other congenital anomalies of heart, Congenital stenosis of aortic valve[BIKUSPINEN AORTALÄPPÄ]
+∞
23.4
22
*
K83
ICPC
Heart valve disease NOS
262.0
23.2
23
*
FM2CE, ,
NOMESCO Finland
8.6
21.5
30
41
FMD40
NOMESCO Finland
Replacement of aortic root using pulmonary autograft and reimplantation of coronary arteries (Ross)
+∞
21.3
20
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
7.4
20.5
33
53
5273
FHL
Repair with flap prosthesis or graft
+∞
20.2
19
*
C03DA01
ATC
spironolactone; oral
7.1
19.8
33
55
61
HP
Catheterization and pressure measurement of the left side of the heart
52.4
19.7
23
5
5253
FHL
Cardiac lung machine
105.6
17.9
19
*
C01AA05
ATC
digoxin; systemic
17.2
17.8
28
19
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
+∞
15.9
15
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
+∞
15.9
15
*
31
HP
Congenital heart failure surgery
42.1
15.7
19
5
I48
ICD-10 Finland
Atrial fibrillation and flutter
5.8
15.7
32
65
WX408
NOMESCO Finland
General anesthesy, balanced
3.6
15.1
76
307
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
62.1
15.1
17
*
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
17.4
14.9
23
15
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
87.4
14.8
16
*
FCA60
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of composite graft with mechanical valve prosthesis
87.4
14.8
16
*
XF640, ,
NOMESCO Finland
26.3
14.1
19
8
Q25.40
ICD-10 Finland
Aortic hypoplasia
+∞
13.7
13
*
74673
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae aortae
+∞
13.7
13
*
ZXD10
NOMESCO Finland
Scheduled procedure
3.1
12.8
89
428
WX892
NOMESCO Finland
Monitored bed care
5.1
12.7
29
65
207
Kela drug reimbursment
Chronic arrhythmias
6.1
12.5
23
42
Q25.0
ICD-10 Finland
Patent ductus arteriosus
20.7
11.8
17
9
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
24.9
11.8
16
7
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
69.6
11.8
13
*
Q25.3
ICD-10 Finland
Stenosis of aorta
+∞
11.6
11
*
PD5CG
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
127.8
11.6
12
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.0
11.2
77
362
WZC30
NOMESCO Finland
Teaching
3.8
11.1
39
122
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
14.1
10.9
18
14
TFP20
NOMESCO Finland
Cardiodefibrillation
12.3
10.8
19
17
C07AA07
ATC
sotalol; systemic
17.4
10.6
16
10
FMA20
NOMESCO Finland
Plastic repair of aortic valve for stenosis
+∞
10.5
10
*
Q23.9
ICD-10 Finland
Congenital malformation of aortic and mitral valves, unspecified
+∞
10.5
10
*
Z2221
NOMESCO Finland
Medical doctor
2.9
10.4
70
323
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
27.8
10.0
13
5
I50.9
ICD-10 Finland
Heart failure, unspecified
5.3
9.8
21
44
Z98.8
ICD-10 Finland
Other specified postsurgical states
23.2
9.5
13
6
ZXE40
NOMESCO Finland
More than seven and less than nine hours
9.9
9.3
18
20
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
16.7
9.2
14
9
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
38.8
9.1
11
*
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
25.5
9.0
12
5
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
8.9
53
227
ZXD05
NOMESCO Finland
Urgent procedure
2.7
8.8
66
318
PD5BG
NOMESCO Finland
MRI examination of thoracal and abdominal aortta with high intensity magnet
94.3
8.5
9
*
C09AA02
ATC
enalapril; systemic
4.0
8.5
26
73
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
11.6
8.5
15
14
FC1BC
NOMESCO Finland
Extensive angiography of thoracal aortta
+∞
8.4
8
*
FCA50
NOMESCO Finland
Resection and reconstruction of ascending aorta using tube graft
+∞
8.4
8
*
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
9.6
8.2
16
18
R4110
NOMESCO Finland
Physiotherapy
2.6
8.1
67
338
K84
ICPC
Heart disease other
19.4
7.7
11
6
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
26.3
7.7
10
*
K99
ICPC
Cardiovascular disease other
26.3
7.7
10
*
ZX120
NOMESCO Finland
Intravenous
3.9
7.6
24
69
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.5
7.5
66
340
Z01.8
ICD-10 Finland
Other specified special examinations
2.7
7.5
51
232
I47.1
ICD-10 Finland
Supraventricular tachycardia
7.4
7.5
17
25
C07AB02
ATC
metoprolol; systemic
3.6
7.5
27
85
XF622
NOMESCO Finland
Measurement of minute volume of heart
16.6
7.3
11
7
62
HP
Catheterization and pressure measurement of the right side of the heart
31.4
7.2
9
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.2
7.2
20
52
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
10.7
7.2
13
13
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.6
7.0
52
246
Q21.10
ICD-10 Finland
Persistent ostium secundum
8.8
7.0
14
17
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
41.7
6.8
8
*
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
41.7
6.8
8
*
WX402
NOMESCO Finland
General anaesthesia
2.4
6.8
58
293
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
23.5
6.7
9
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
23.5
6.7
9
*
81
HP
Angiography of the heart and coronary arteries
12.9
6.7
11
9
Q25.48
ICD-10 Finland
Other congenital malformations of the aorta
72.3
6.5
7
*
I35.9
ICD-10 Finland
Aortic valve disorder, unspecified
72.3
6.5
7
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
6.4
93
586
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
9.8
6.4
12
13
PD5DG
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
+∞
6.3
6
*
AP3
HP
Catheterization of the right and left side of the heart
+∞
6.3
6
*
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
6.3
6
*
5271
FHL
Valvulotomy
+∞
6.3
6
*
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
+∞
6.3
6
*
FJE42
NOMESCO Finland
Percutaneous transluminal expansion of pulmonary valve
+∞
6.3
6
*
74719
ICD-8 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta
+∞
6.3
6
*
5513
FHL
Coarctation resection, plastic or bypass
+∞
6.3
6
*
I49.5
ICD-10 Finland
Sick sinus syndrome
13.1
6.2
10
8
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
3.3
6.1
25
85
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
134
213
21.70
96.85
9.0
5.5
635.11
913.90
ng/l
0.87
126
173
58
70
11.75
47.43
4.6
4.3
122.79
146.98
ng/l
0.28
53
63
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
36
32
13.81
35.59
27.8
11.4
0.37
0.40
iu/ml
0.12
20
20
49
74
8.72
32.90
2.5
2.4
17.06
10.17
ug/l
0.81
49
67
49
85
7.55
28.90
18.0
7.1
86.82
94.65
%
1.44
49
85
37
67
6.69
20.58
4.6
7.4
169.54
170.96
%
0.04
37
67
85
367
3.49
15.21
4.6
2.8
50.25
25.91
ng/l
0.96
61
198
78
323
3.50
14.85
3.8
2.8
—
—
—
0
0
34
77
5.21
14.75
35.2
17.3
0.80
0.65
%
2.11
34
77
34
81
4.94
13.87
34.7
16.6
1.35
1.49
%
0.25
34
81
113
647
3.01
11.52
9.4
7.6
18.18
13.09
umol/l
1.23
106
621
66
285
3.08
11.21
6.3
3.1
1.55
1.16
mg/l
0.44
44
217
48
175
3.38
10.78
21.1
13.2
106.52
104.46
mmol/l
2.80
48
175
40
131
3.64
10.58
32.3
16.0
5.38
5.23
kpa
0.54
40
124
40
131
3.64
10.58
31.7
16.1
0.77
0.78
mmol/l
0.01
35
110
40
131
3.64
10.58
32.3
16.0
15.49
13.63
kpa
1.37
40
125
105
597
2.82
10.53
4.3
3.0
—
—
estimate
—
0
0
14
6
25.12
10.41
4.6
8.5
5.16
4.97
kpa
—
14
6
14
6
25.12
10.41
4.6
8.5
6.41
5.95
kpa
—
14
6
22
31
7.93
9.86
1.2
1.5
—
—
—
0
0
20
42
5.23
9.31
10.2
18.0
74.31
69.58
%
0.61
20
42
25
71
3.93
8.03
8.6
13.8
0.80
0.62
%
2.64
25
71
17
23
8.04
7.88
4.1
3.9
79.53
92.96
%
0.80
17
23
11
6
19.40
7.70
1.8
2.8
166.18
108.50
%
—
11
6
25
75
3.71
7.42
8.6
13.2
1.11
1.59
%
1.74
25
75
41
173
2.77
6.93
18.1
9.9
4.99
5.03
kpa
0.13
41
167
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
11
9
12.92
6.67
1.8
2.2
140.45
109.44
%
—
11
9
66
358
2.33
6.55
2.7
3.1
3.33
2.59
mg/l
1.37
61
317
39
165
2.74
6.54
18.1
10.0
2.07
1.12
mmol/l
2.19
34
117
46
216
2.52
6.25
36.0
15.3
25.14
25.09
mmol/l
0.04
46
216
48
237
2.40
5.82
11.0
10.4
1.44
1.36
mmol/l
0.07
43
201
169
1414
4.19
5.80
35.3
15.0
139.23
139.55
mmol/l
1.33
169
1389
98
648
2.12
5.77
21.8
12.2
1.18
1.21
mmol/l
3.32
93
594
169
1418
4.14
5.69
35.2
14.9
4.01
3.95
mmol/l
2.25
169
1389
13
20
6.92
5.67
1.5
1.5
—
—
—
0
0
92
599
2.10
5.59
29.0
12.5
1.18
1.22
mmol/l
4.83
92
571
34
147
2.62
5.42
42.6
15.7
1.51
1.47
mmol/l
0.07
34
142
50
265
2.23
5.08
11.6
11.3
1.28
1.23
mmol/l
0.59
50
256
25
96
2.86
4.98
7.9
7.2
—
—
—
0
0
17
54
3.37
4.62
2.8
1.7
—
—
—
0
0
13
30
4.59
4.22
1.0
1.3
9.57
4.50
u/ml
—
7
18
143
1157
2.15
4.20
18.8
10.5
99.21
97.33
ml/min/173m2
0.48
131
998
13
32
4.30
3.99
1.0
1.3
2.40
1.62
u/ml
—
5
16
37
193
2.15
3.85
2.6
1.9
—
—
—
0
0
13
35
3.92
3.68
1.9
2.3
—
—
—
0
0
38
207
2.06
3.52
13.3
10.1
24.03
23.67
mmol/l
0.45
38
207
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
6
6
10.28
3.52
1.8
1.0
75.50
133.33
%
—
6
6
31
158
2.16
3.40
2.8
1.7
—
—
—
0
0
10
23
4.54
3.36
2.1
2.5
—
—
—
0
0
10
24
4.35
3.25
5.5
5.1
3.99
3.88
mmol/l
—
10
24
124
995
1.79
3.22
8.5
7.4
90.06
96.26
u/l
0.54
124
946
30
156
2.11
3.13
2.9
1.8
—
—
—
0
0
8
17
4.87
2.95
1.6
1.4
—
—
—
0
0
166
1485
2.52
2.92
26.2
13.1
36.80
23.79
mg/l
4.47
152
1109
12
47
2.66
2.32
1.5
1.4
—
—
—
0
0
168
1540
2.36
2.26
26.8
14.2
70.33
70.89
umol/l
0.10
168
1521
5
9
5.68
2.23
1.2
2.9
1.20
1.19
mmol/l
—
5
9
7
19
3.79
2.17
9.4
1.3
13.43
13.26
%
—
7
19
13
56
2.42
2.10
1.8
1.6
—
—
—
0
0
8
27
3.05
1.96
1.1
1.5
—
—
—
0
0
13
58
2.34
1.96
1.8
1.7
—
—
—
0
0
6
16
3.84
1.95
5.8
3.1
1.00
0.56
index
—
6
16
18
93
2.04
1.93
2.6
2.5
—
—
—
0
0
13
59
2.30
1.89
2.2
1.2
—
—
—
0
0
7
23
3.12
1.82
1.3
1.6
—
—
—
0
0
6
18
3.41
1.76
1.3
6.4
14.17
17.69
%
—
6
18
24
147
1.73
1.57
1.3
1.3
469.00
327.74
u/ml
0.17
24
132
49
361
1.49
1.52
4.4
3.9
0.13
0.01
estimate
0.44
16
118
9
37
2.51
1.50
1.7
1.5
—
—
—
0
0
7
29
2.47
1.40
1.0
1.1
—
—
—
0
0
7
29
2.47
1.40
2.6
5.3
—
—
—
0
0
53
407
1.43
1.32
6.1
4.0
0.50
0.15
e6/l
0.80
45
290
8
35
2.34
1.28
1.9
1.4
—
—
—
0
0
8
38
2.16
1.20
1.9
1.6
—
—
—
0
0
5
20
2.54
1.16
1.2
1.5
—
—
—
0
0
7
30
2.39
1.13
2.6
5.1
18.71
6.27
%
—
7
30
8
41
1.99
1.10
2.8
1.3
—
—
—
0
0
8
41
1.99
1.10
2.8
1.3
—
—
—
0
0
7
33
2.17
1.07
1.7
1.3
—
—
—
0
0
7
33
2.17
1.07
1.3
1.4
—
—
—
0
0
16
100
1.66
1.00
3.3
3.2
0.11
0.16
e6/l
0.35
16
94
5
23
2.21
0.98
1.6
10.9
3.26
8.91
pmol/l
—
5
23
7
37
1.93
0.95
1.7
1.6
—
—
—
0
0
13
78
1.72
0.94
1.1
1.3
—
—
—
0
0
10
55
1.87
0.94
1.1
1.1
—
52.74
—
0
9
6
29
2.10
0.90
1.5
1.5
—
—
—
0
0
66
555
1.30
0.89
2.0
2.0
—
—
—
0
0
108
968
1.29
0.89
13.8
11.9
3.97
3.71
e9/l
0.75
100
829
15
96
1.61
0.87
3.3
1.8
—
—
—
0
0
11
65
1.74
0.84
1.8
6.3
1.21
1.23
mmol/l
0.61
11
57
6
32
1.90
0.82
1.3
2.1
—
—
—
0
0
173
1678
1.80
0.81
49.1
20.9
39.07
41.20
%
5.75
173
1665
173
1678
1.80
0.81
41.7
19.8
4.47
4.68
e12/l
5.07
173
1637
173
1679
1.78
0.81
43.7
20.1
131.06
138.77
g/l
6.10
173
1667
173
1677
1.81
0.81
41.5
19.8
89.18
88.39
fl
1.54
173
1665
173
1675
1.84
0.81
41.7
19.9
234.29
258.53
e9/l
6.12
173
1640
6
33
1.85
0.80
1.7
2.4
—
—
—
0
0
17
241
0.67
0.78
3.4
3.4
19.78
21.81
%
—
7
78
0
28
0.00
0.77
0.0
1.1
—
—
—
0
0
5
24
2.11
0.75
7.2
5.3
4.49
2.44
ug/l
—
5
24
11
68
1.66
0.73
2.3
2.0
—
—
—
0
0
118
1086
1.25
0.70
4.5
4.1
14.81
14.64
pmol/l
0.31
111
1018
13
187
0.67
0.65
2.4
2.5
0.66
0.68
ug/l
—
5
85
82
735
1.21
0.60
4.9
3.6
0.00
0.00
estimate
-0.00
19
127
6
36
1.69
0.57
1.3
1.5
—
—
—
0
0
82
740
1.20
0.55
4.9
3.6
0.00
0.00
estimate
-0.00
19
120
16
118
1.39
0.52
4.4
7.7
45.36
63.74
ng/l
1.28
16
111
9
65
1.40
0.51
1.1
1.1
1.48
1.47
g/l
—
9
65
14
101
1.42
0.51
1.9
2.6
815.04
6899.32
u/l
—
8
43
151
1449
1.26
0.50
37.9
16.9
334.86
335.60
g/l
0.46
151
1442
16
121
1.35
0.46
1.6
1.3
36.80
134.50
u/ml
—
5
46
12
86
1.42
0.46
1.9
1.9
—
—
—
0
0
13
96
1.38
0.43
1.9
1.5
—
—
—
0
0
5
33
1.53
0.41
1.4
1.8
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
11.71
—
0
15
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
238.97
—
0
16
12
88
1.39
0.41
1.4
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
1.7
—
233.84
—
0
17
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
7.89
—
0
11
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
2.2
—
146.93
—
0
11
9
66
1.38
0.39
1.1
1.2
0.93
0.90
g/l
—
9
66
30
255
1.21
0.37
7.0
3.8
1.37
1.93
e6/l
0.27
19
136
24
282
0.83
0.33
2.9
4.5
4.41
11.06
mg/mmol
1.08
19
199
18
218
0.81
0.32
3.7
2.3
—
—
—
0
0
7
98
0.70
0.31
5.6
3.8
32.00
30.79
%
—
7
62
59
540
1.14
0.31
3.9
3.3
0.00
0.01
estimate
0.50
14
110
7
57
1.24
0.29
1.7
1.2
—
—
—
0
0
80
750
1.12
0.28
5.0
3.6
0.00
0.00
estimate
-0.00
18
117
14
166
0.83
0.21
2.3
1.5
—
—
—
0
0
30
269
1.14
0.21
6.7
3.6
0.99
0.51
e6/l
0.78
19
145
0
11
0.00
0.21
0.0
5.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
13
155
0.83
0.21
1.1
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
128
1315
0.91
0.20
3.8
3.8
—
—
—
0
0
16
185
0.85
0.19
3.8
2.2
—
—
—
0
0
7
58
1.22
0.18
1.7
1.2
—
—
—
0
0
9
107
0.83
0.13
1.9
1.2
—
—
—
0
0
17
189
0.89
0.12
1.0
1.3
33.65
8.71
u/ml
—
8
69
51
532
0.94
0.10
1.9
2.1
1.53
1.40
mmol/l
0.33
46
483
5
48
1.04
0.09
1.0
4.3
126.00
303.44
e6/l
—
5
34
5
48
1.04
0.09
1.0
4.2
1.40
6.59
e6/l
—
5
32
38
361
1.07
0.09
4.8
3.3
1.02
1.02
kg/l
0.78
30
230
6
54
1.11
0.09
1.0
1.1
—
—
—
0
0
53
549
0.95
0.08
1.3
1.8
0.62
2.40
u/ml
1.33
15
123
36
376
0.95
0.07
2.0
2.3
—
—
—
0
0
42
406
1.04
0.05
2.8
2.9
0.00
0.00
estimate
-0.00
16
96
40
406
0.98
0.00
2.2
2.5
—
—
—
0
0
15
151
0.99
0.00
1.3
1.7
3.35
3.68
mmol/l
—
10
101
42
421
1.00
0.00
2.4
1.8
96.14
97.08
pmol/l
0.06
31
207
19
185
1.03
0.00
2.7
2.7
418.37
359.26
nmol/l
0.45
19
176
0
5
0.00
0.00
0.0
1.0
—
39.40
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
80.22
—
0
5
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
4.94
—
0
5
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
5
51
0.98
-0.00
1.2
4.0
466.60
474.14
mg/l
—
5
51
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
9
94
0.96
-0.00
1.9
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
9.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
9
94
0.96
-0.00
1.8
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.0
—
52.22
—
0
9
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.8
—
214.96
—
0
8
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
—
—
0
0
11
110
1.00
-0.00
2.1
1.8
0.11
0.27
mg/l
—
6
51
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
65
0.92
-0.00
1.5
1.6
—
0.04
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: Q17_CONGENITAL_AORTIC_VALVE_STENOSIS – Congenital aortic valve stenosis
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).