Chronic mastoiditis

H8_MASTCHRON

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H70.1
  • Hospital discharge: ICD-9 3831
  • Hospital discharge: ICD-8 3821|3831
  • Cause of death: ICD-10 H70.1
  • Cause of death: ICD-9 3831
  • Cause of death: ICD-8 3821|3831

2 out of 7 registries used, show all original rules.

1059

4. Check minimum number of events

None

1059

5. Include endpoints

None

1059

6. Filter based on genotype QC (FinnGen only)

953

Control definitions (FinnGen only)

Control exclude
H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H70
Name in latin
Mastoiditis chronica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8589 3987 4494
Only index persons 7007 3397 3610
Unadjusted period prevalence (%)
Whole population 0.12 0.11 0.13
Only index persons 0.13 0.12 0.14
Median age at first event (years)
Whole population 40.57 43.01 38.15
Only index persons 37.44 40.07 34.97

-FinnGen-

Key figures

All Female Male
Number of individuals 953 423 530
Unadjusted period prevalence (%) 0.20 0.15 0.24
Median age at first event (years) 41.32 40.38 42.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
991
Matched controls
9910
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
307.7
520
*
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
307.7
466
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
281.0
256
*
DC1AD
NOMESCO Finland
Temporalbone CT
118.2
278.6
142
14
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
35.8
256.1
165
55
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
105.0
183.9
95
10
H66.0
ICD-10 Finland
Acute suppurative otitis media
12.5
177.7
191
186
UDC00
NOMESCO Finland
Ear microscopy
9.2
175.3
245
340
H65.3
ICD-10 Finland
Chronic mucoid otitis media
390.2
165.4
162
5
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
464.6
162.5
158
*
H66.9
ICD-10 Finland
Otitis media, unspecified
12.5
156.0
165
156
DFF00
NOMESCO Finland
Pure tone audiometry
6.3
140.6
293
615
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
+∞
134.5
126
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
49.2
125.0
73
16
Z01.1
ICD-10 Finland
Examination of ears and hearing
5.2
120.2
326
855
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
264.9
116.5
117
5
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
13.6
96.2
93
75
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
27.5
90.1
62
24
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
197.7
87.8
90
5
H60.3
ICD-10 Finland
Other infective otitis externa
10.7
85.0
96
98
H65.2
ICD-10 Finland
Chronic serous otitis media
449.2
84.4
83
*
S02CA02
ATC
flumetasone and antiinfectives; otic
6.4
82.8
151
271
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
21.3
81.6
62
31
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.7
80.4
361
1326
Z97.4
ICD-10 Finland
Presence of external hearing-aid
5.8
77.3
156
308
DCD00
NOMESCO Finland
Myringoplasty
+∞
76.0
72
*
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
75.0
71
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
5.6
74.0
157
324
H65.0
ICD-10 Finland
Acute serous otitis media
28.6
72.3
49
18
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
4.9
71.2
178
423
TDA90
NOMESCO Finland
Removal wax from ear
13.0
68.2
67
55
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
+∞
67.5
64
*
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
62.1
59
*
H60.8
ICD-10 Finland
Other otitis externa
8.2
60.7
84
111
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
5.9
60.1
116
218
DEB10
NOMESCO Finland
Attico-antro-mastoidectomy
+∞
58.9
56
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
+∞
57.9
55
*
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
16.6
54.1
46
29
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
52.6
50
*
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
+∞
52.6
50
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.9
52.4
368
1692
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
21.9
50.8
38
18
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
4.6
49.6
129
313
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
6.9
45.7
73
113
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
+∞
44.1
42
*
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
43.0
41
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
149.7
41.1
43
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.1
40.9
206
777
DEB30
NOMESCO Finland
Radical mastoidectomy
413.7
40.4
40
*
50099
ICD-8 Finland
Hypertrophy of tonsils and adenoids
3.7
39.5
138
414
4141
FHL
Myringoplasty (also for reasons other than inflammation)
402.8
39.4
39
*
H66.1
ICD-10 Finland
Chronic tubotympanic suppurative otitis media
391.9
38.3
38
*
H66
ICD-10 Finland
Suppurative and unspecified otitis media
7.8
38.1
54
73
4151
FHL
Reoperation for chronic otitis media
+∞
37.7
36
*
DCD10
NOMESCO Finland
Tympanoplasty
+∞
37.7
36
*
DFF15
NOMESCO Finland
Speech audiometry
4.1
37.5
110
291
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
+∞
36.7
35
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
36.7
35
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.4
35.8
143
467
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
69.3
35.2
40
6
DAX08
NOMESCO Finland
Fitting of hearing aid
3.7
35.0
121
359
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
5.5
34.3
68
130
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.3
34.1
564
3655
4122
FHL
Tympanostomy (tympanic tube)
+∞
33.5
32
*
R5120
NOMESCO Finland
Preparation of an aid
4.8
33.2
78
173
H70.0
ICD-10 Finland
Acute mastoiditis
+∞
30.4
29
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
30.4
29
*
38199
ICD-8 Finland
Otitis media without mention of mastoiditis, Unspecified
+∞
30.4
29
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
110.1
29.8
32
*
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
+∞
29.3
28
*
H61.2
ICD-10 Finland
Impacted cerumen
3.4
28.6
114
370
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
28.3
27
*
4144
FHL
Mastoidectomy or aticomastoidectomy
+∞
27.2
26
*
H04
ICPC
Ear discharge
4.5
26.4
66
154
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
138.6
25.7
27
*
H92.0
ICD-10 Finland
Otalgia
3.7
25.0
82
234
DGW00
NOMESCO Finland
Dilatation of eustachian tube
+∞
24.1
23
*
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
+∞
23.0
22
*
DEB00
NOMESCO Finland
Cortical mastoidectomy
235.2
22.7
23
*
H66.2
ICD-10 Finland
Chronic atticoantral suppurative otitis media
+∞
22.0
21
*
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
4.0
21.3
63
167
H68.1
ICD-10 Finland
Obstruction of Eustachian tube
8.6
20.2
26
31
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
203.9
19.6
20
*
J01DA06
ATC
[U] cefuroxime
2.3
19.4
170
822
R01AD08
ATC
fluticasone; nasal
2.0
19.3
279
1634
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
18.8
18
*
4145
FHL
Tympanomastoidectomy, includes possible tympanoplasty
193.5
18.6
19
*
H60
ICD-10 Finland
Otitis externa
3.3
18.4
72
230
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.0
18.2
85
302
J01MA02
ATC
ciprofloxacin; systemic
1.8
17.9
428
2933
H72.8
ICD-10 Finland
Other perforations of tympanic membrane
96.8
17.6
19
*
R5140
NOMESCO Finland
Monitoring the use of the aid
2.3
17.6
144
675
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
16.0
17.6
28
18
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
3.5
17.1
60
179
H01
ICPC
Ear pain/earache
2.4
17.0
122
539
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
16.9
275
1664
J01DA01
ATC
[U] cefalexin
1.8
16.8
616
4750
38299
ICD-8 Finland
Unspecified otitis media with mastoiditis
+∞
16.7
16
*
H92.1
ICD-10 Finland
Otorrhoea
172.8
16.5
17
*
H60.4
ICD-10 Finland
Cholesteatoma of external ear
30.6
16.2
21
7
J01DC02
ATC
cefuroxime; systemic
3.1
15.9
68
229
J01FF01
ATC
clindamycin; systemic
1.8
15.8
283
1762
H73.1
ICD-10 Finland
Chronic myringitis
+∞
15.7
15
*
3831A
ICD-9 Finland
Mastoiditis and related conditions, Chronic mastoiditis
+∞
14.6
14
*
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
+∞
14.6
14
*
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
152.2
14.5
15
*
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
11.6
14.3
26
23
46100
ICD-8 Finland
Acute sinusitis, Maxillaris
5.0
13.9
30
62
H02AB06
ATC
prednisolone; systemic
1.7
13.6
477
3548
H70.9
ICD-10 Finland
Mastoiditis, unspecified
+∞
13.6
13
*
RK320, ,
NOMESCO Finland
11.1
13.1
24
22
H02AB04
ATC
methylprednisolone; systemic
2.0
12.9
155
840
J01CA04
ATC
amoxicillin; systemic
1.8
12.9
770
6547
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
70.8
12.6
14
*
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
24.7
12.5
17
7
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.5
12.2
42
124
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.4
12.2
43
129
4451
FHL
Guitar cutting
8.8
12.1
25
29
J01FA10
ATC
azithromycin; systemic
1.6
12.0
492
3766
Z98.8
ICD-10 Finland
Other specified postsurgical states
5.6
11.7
22
40
RK520, ,
NOMESCO Finland
19.2
11.6
17
9
J33.8
ICD-10 Finland
Other polyp of sinus
3.9
11.5
34
90
J32.4
ICD-10 Finland
Chronic pansinusitis
5.1
11.5
24
48
DC1BD
NOMESCO Finland
Temporal bone extensive CT
+∞
11.5
11
*
4143
FHL
Atticotomy or atticoanthromy through the ear canal
+∞
11.5
11
*
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
+∞
11.5
11
*
J01MA12
ATC
levofloxacin; systemic
1.8
11.2
206
1277
RK420, ,
NOMESCO Finland
43.8
10.9
13
*
50301
ICD-8 Finland
Chronic sinusitis, Maxillaris NUD
5.3
10.6
21
40
J01DB01
ATC
cefalexin; oral
1.7
10.5
777
6754
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
111.2
10.4
11
*
DED00
NOMESCO Finland
Obliteration of cavity after partial excision of mastoid
+∞
10.4
10
*
38310
ICD-8 Finland
Mastoiditis without mention of otitis media, Chronic
+∞
10.4
10
*
DE2BG
NOMESCO Finland
Acoustic channel MRI examination with high intensity magnet
8.3
10.3
22
27
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.7
10.1
53
201
J01DA08
ATC
[U] cefaclor
2.2
9.8
88
426
4146
FHL
Radical cutting (bridge broken)
+∞
9.4
9
*
H74.4
ICD-10 Finland
Polyp of middle ear
+∞
9.4
9
*
4224
FHL
Endonasal anthrostomy
5.2
9.4
19
37
J01FA09
ATC
clarithromycin; systemic
1.6
9.3
268
1861
H29
ICPC
Ear symptom/complaint other
1.9
9.2
128
725
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
9.2
488
3873
H61.8
ICD-10 Finland
Other specified disorders of external ear
5.1
9.1
19
38
EMB30
NOMESCO Finland
Adenotomy
15.7
9.0
14
9
DE2DG
NOMESCO Finland
Acoustic channel very extensive MRI examination with high intensity magnet
37.0
9.0
11
*
H02AB07
ATC
prednisone; oral
1.8
9.0
141
830
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.1
9.0
82
400
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.3
8.9
71
328
RK110, ,
NOMESCO Finland
8.7
8.8
18
21
R01BA52
ATC
pseudoephedrine, combinations; oral
1.6
8.5
256
1789
1450
FHL
Otomicroscopy
27.8
8.5
11
*
J01DA09
ATC
[U] cefadroxil
1.6
8.5
241
1664
S02CA03
ATC
hydrocortisone and antiinfectives; otic
90.8
8.4
9
*
38799
ICD-8 Finland
Other disease of ear and mastoid process, Other
90.8
8.4
9
*
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
+∞
8.3
8
*
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
8.1
635
5397
H60.0
ICD-10 Finland
Abscess of external ear
11.8
8.1
14
12
N07CA01
ATC
betahistine; oral
2.1
8.1
82
417
50499
ICD-8 Finland
Deflected nasal septum
3.6
8.0
26
74
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
7.8
282
2050
H71
ICPC
Acute otitis media/myringitis
6.4
7.7
19
30
D07AC01
ATC
betamethasone; topical
1.5
7.7
340
2573
RK120, ,
NOMESCO Finland
15.2
7.7
12
8
A02BC01
ATC
omeprazole; systemic
1.5
7.7
269
1940
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
7.7
181
1191
50300
ICD-8 Finland
Chronic sinusitis, Maxillaris cum empyemate
7.2
7.5
17
24
R01AD09
ATC
mometasone; nasal
1.5
7.3
376
2926
DC1AA
NOMESCO Finland
Temporalbone X-ray examination
+∞
7.3
7
*
38200
ICD-8 Finland
Acute / Acute otitis media with mastoiditis
+∞
7.3
7
*
DE2CG
NOMESCO Finland
Acoustic channel extensive MRI examination with high intensity magnet
4.3
7.2
18
42
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
3.2
7.2
27
85
J01DC04
ATC
cefaclor; oral
4.4
7.0
17
39
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
6.8
99
569
ZXA05
NOMESCO Finland
Left side
1.5
6.8
238
1711
H91.9
ICD-10 Finland
Hearing loss, unspecified
2.2
6.8
59
283
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
4.3
6.8
17
40
H60.2
ICD-10 Finland
Malignant otitis externa
40.3
6.8
8
*
WX722
NOMESCO Finland
PEEP
2.2
6.6
53
246
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.2
6.6
54
253
4730A
ICD-9 Finland
Chronic sinusitis, Maxillary
3.4
6.6
23
69
WZC00
NOMESCO Finland
Treatment plan or consultation
1.4
6.5
321
2466
D07AC13
ATC
mometasone; topical
1.5
6.5
254
1868
AA1AD
NOMESCO Finland
CT of head and brain
1.5
6.4
300
2280
RK290, ,
NOMESCO Finland
14.4
6.4
10
7
R06.0
ICD-10 Finland
Dyspnoea
1.5
6.4
270
2015
S02AA03
ATC
boric acid; otic
5.6
6.3
17
31
ZXC10
NOMESCO Finland
Use of laser
3.0
6.3
27
92
4148
FHL
Radical cutting and cavity filling
+∞
6.3
6
*
38400
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) acuta
+∞
6.3
6
*
J47
ICD-10 Finland
Bronchiectasis
3.1
6.2
25
82
A02BC02
ATC
pantoprazole; systemic
1.4
6.2
638
5561
T16
ICD-10 Finland
Foreign body in ear
5.4
6.2
17
32
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.5
6.2
36
145
R03AK08
ATC
formoterol and beclometasone; inhalant
2.3
6.1
46
208

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
276
1010
3.40
59.57
3.0
1.7
—
—
—
0
0
204
1052
2.18
19.93
1.9
1.5
—
—
—
0
0
227
1331
1.92
15.18
2.2
2.0
—
—
—
0
0
181
1054
1.88
12.13
5.4
5.1
31.70
32.15
%
0.21
133
675
150
831
1.95
11.66
3.1
4.2
7.37
7.36
ph
0.25
108
602
395
2906
1.60
11.12
7.4
5.9
—
—
—
0
0
113
635
1.88
8.35
3.7
3.8
7.41
7.41
ph
0.39
101
538
115
650
1.87
8.34
3.7
3.8
5.16
5.16
kpa
0.00
110
627
355
2750
1.45
7.01
2.8
2.7
50.29
92.02
u/l
0.83
336
2568
488
4033
1.41
6.64
8.1
6.2
9.05
9.02
%
0.07
458
3778
82
448
1.91
6.61
3.5
4.0
—
—
—
0
0
349
2720
1.44
6.58
5.1
4.4
—
—
—
0
0
173
1167
1.58
6.57
1.4
1.2
—
—
—
0
0
494
4103
1.41
6.47
8.0
6.2
25.96
26.49
%
0.49
469
3887
486
4027
1.41
6.44
8.1
6.2
0.68
0.67
%
0.22
455
3764
485
4023
1.40
6.36
8.0
6.1
2.98
2.87
%
0.41
456
3768
484
4016
1.40
6.32
7.8
6.1
58.21
58.20
%
0.00
462
3836
405
3261
1.41
6.29
2.5
2.2
—
—
—
0
0
615
5329
1.41
6.15
3.7
3.4
55.42
52.29
u/l
0.26
576
4991
350
2787
1.40
5.66
2.4
2.2
158.36
244.00
u/l
2.00
336
2649
374
3021
1.38
5.51
3.6
3.3
1919.41
1592.92
ng/l
0.76
320
2623
510
4355
1.35
5.18
19.6
17.4
1.29
1.31
inr
0.35
433
3682
483
4103
1.35
5.02
7.6
6.7
1.21
1.21
mmol/l
1.73
437
3762
472
4050
1.32
4.36
4.5
5.1
34.26
35.14
g/l
2.45
438
3780
421
3560
1.32
4.30
5.0
4.1
36.05
87.78
ng/l
1.35
330
2687
308
2492
1.34
4.27
2.6
2.3
2.96
2.93
mg/l
0.06
260
2125
584
5181
1.31
4.13
6.8
5.4
7.01
6.77
mmol/l
1.50
560
4949
39
197
2.02
4.02
1.3
1.4
68.24
61.55
mmol/l
0.49
29
164
218
1686
1.38
4.01
1.8
1.8
1097.67
1184.86
nmol/l
0.62
156
1264
21
81
2.63
3.99
3.6
3.4
17.00
13.28
index
—
7
50
520
4557
1.30
3.96
7.8
7.4
1.21
1.21
mmol/l
1.21
439
3916
109
742
1.53
3.96
1.4
1.4
—
—
—
0
0
114
785
1.51
3.92
4.0
3.2
235.77
232.07
ng/l
0.03
104
723
145
1049
1.45
3.90
4.2
3.2
4.51
5.49
e9/l
0.72
108
905
344
2859
1.31
3.89
3.1
2.5
—
—
—
0
0
29
133
2.22
3.83
2.3
1.6
0.71
0.78
g/l
0.13
19
111
20
77
2.63
3.82
2.3
1.2
0.46
0.44
g/l
0.06
13
61
20
77
2.63
3.82
2.3
1.2
7.62
7.60
g/l
0.01
13
61
20
77
2.63
3.82
2.2
1.2
2.91
2.86
g/l
0.06
13
61
126
893
1.47
3.77
1.9
2.3
0.20
0.20
g/l
0.03
113
825
11
24
4.62
3.75
2.5
1.9
—
—
—
0
0
527
4651
1.28
3.70
6.6
6.7
10.92
12.11
umol/l
2.37
509
4455
20
79
2.56
3.65
2.0
1.2
—
—
—
0
0
207
1614
1.36
3.59
3.3
2.6
12.06
12.65
umol/l
0.54
196
1505
10
21
4.80
3.56
1.3
1.3
—
—
—
0
0
620
5605
1.28
3.51
6.0
5.2
90.00
2613.50
e6/l
—
10
100
494
4357
1.27
3.36
7.7
6.0
0.04
0.04
e9/l
1.10
433
3716
704
6486
1.29
3.34
9.5
8.4
80.20
80.73
u/l
0.12
661
6141
166
1266
1.37
3.31
5.4
5.8
1.02
1.03
mmol/l
0.27
148
1168
461
4041
1.26
3.28
2.5
2.3
96.13
94.72
pmol/l
0.23
245
2159
264
2159
1.30
3.27
3.1
2.5
—
—
—
0
0
137
1014
1.41
3.26
2.5
2.9
7.79
9.01
umol/l
0.42
119
908
505
4487
1.26
3.15
7.9
6.2
0.21
0.20
e9/l
0.52
449
3893
490
4342
1.25
3.12
7.7
6.0
0.62
0.60
e9/l
0.90
429
3699
196
1547
1.33
3.12
3.3
3.3
0.80
0.82
mmol/l
1.73
187
1462
497
4417
1.25
3.07
7.8
6.1
1.78
1.88
e9/l
1.24
449
3868
668
6142
1.27
3.06
4.7
4.2
15.03
14.93
pmol/l
0.46
595
5575
231
1877
1.30
2.98
1.7
1.7
1.20
1.46
mg/l
0.88
174
1473
347
2967
1.26
2.98
3.7
3.5
53.07
48.26
mg/l
0.20
223
1954
41
236
1.77
2.93
4.3
3.2
2.24
1.81
index
0.20
17
130
28
143
1.99
2.87
3.1
2.9
4.28
4.38
e9/l
0.08
28
143
354
3048
1.25
2.83
4.5
4.2
9.66
8.83
mg/mmol
0.13
203
1941
597
6460
0.81
2.67
28.1
23.6
331.30
331.87
g/l
0.73
592
6426
34
192
1.80
2.61
4.5
3.9
—
—
—
0
0
188
1512
1.30
2.61
3.4
2.6
2.29
2.27
g/l
0.22
177
1409
447
3978
1.23
2.57
3.4
2.9
—
—
estimate
—
0
0
176
1407
1.31
2.55
3.4
2.6
21.00
22.57
%
0.84
165
1321
359
3127
1.23
2.53
5.0
3.9
—
0.69
—
0
13
355
3092
1.23
2.49
4.1
3.5
7.04
7.51
mmol/l
1.17
269
2595
31
173
1.82
2.48
4.7
4.6
2.36
2.63
mmol/l
0.24
25
114
14
57
2.48
2.45
1.2
1.8
42.17
36.38
%
0.76
14
57
38
227
1.70
2.43
1.3
1.2
18.40
5.13
u/ml
—
5
33
222
1842
1.26
2.40
3.4
3.0
513.87
537.49
mosm/kgh2o
0.99
194
1616
197
1612
1.28
2.39
1.7
1.4
2.60
2.60
g/l
0.02
114
982
20
97
2.08
2.38
2.5
1.5
38.68
39.29
ng/l
0.01
20
97
834
7962
1.30
2.37
23.1
17.9
26.37
26.39
mg/l
0.01
739
6687
220
1828
1.26
2.35
5.2
4.2
151.96
309.03
ng/l
1.65
182
1503
115
878
1.35
2.30
7.4
7.2
10.93
10.77
mmol/l
0.08
109
844
50
326
1.56
2.29
1.4
1.2
—
—
—
0
0
58
395
1.50
2.19
1.4
1.3
—
—
—
0
0
529
4835
1.20
2.19
10.2
9.5
4.27
4.23
e9/l
0.14
465
4203
796
7577
1.26
2.17
7.7
6.9
40.66
39.86
mmol/mol
1.67
730
7063
322
2819
1.21
2.09
4.4
3.5
—
—
—
0
0
87
650
1.37
2.01
3.5
3.0
5.93
6.07
ph
0.85
50
451
91
685
1.36
2.01
3.1
2.6
10.55
11.11
g/l
0.83
86
627
58
403
1.47
2.01
2.3
2.2
0.00
0.01
estimate
0.50
11
115
258
2221
1.22
1.97
4.6
4.3
86.64
86.35
%
0.06
248
2179
25
142
1.78
1.94
2.4
2.6
—
—
—
0
0
62
443
1.43
1.87
2.9
2.5
—
—
—
0
0
43
286
1.53
1.85
3.3
5.6
1.26
1.35
mmol/l
0.27
36
255
277
2418
1.20
1.82
4.0
3.6
0.03
0.04
estimate
0.04
88
768
140
1137
1.27
1.82
1.3
1.3
534.81
433.02
titre
0.21
27
258
35
223
1.59
1.81
1.4
1.1
—
—
—
0
0
776
7410
1.22
1.80
4.7
4.4
1.36
1.28
mmol/l
2.28
690
6731
20
109
1.85
1.78
1.6
2.3
0.56
0.73
mmol/l
0.09
20
104
11
47
2.36
1.78
1.3
2.0
77.82
71.93
%
1.16
11
42
35
225
1.58
1.75
2.7
2.2
119.40
127.39
g/l
1.51
25
175
102
800
1.31
1.74
2.2
2.2
0.00
0.02
estimate
0.50
16
158
5
13
3.86
1.71
1.0
1.2
—
—
—
0
0
72
538
1.36
1.70
2.3
1.8
0.95
1.46
g/l
2.50
67
496
260
2271
1.20
1.69
2.9
2.9
363.71
355.34
umol/l
0.55
224
1972
53
376
1.43
1.68
1.9
2.1
262.11
514.17
ug/l
0.98
53
355
430
3924
1.17
1.66
3.7
3.1
146.61
141.65
ug/l
0.13
375
3617
773
7400
1.20
1.63
5.9
5.3
2.00
1.98
mu/l
0.13
701
6770
19
106
1.81
1.59
2.1
2.7
—
—
—
0
0
126
1028
1.26
1.59
1.6
1.6
—
—
—
0
0
103
821
1.28
1.57
2.7
2.1
433.55
385.43
nmol/l
1.04
91
759
17
92
1.86
1.56
1.1
1.0
0.78
0.77
u/ml
—
7
43
49
348
1.43
1.56
2.3
3.2
576.60
305.08
mg/l
0.48
15
145
318
2845
1.17
1.55
3.4
3.4
31.16
35.57
u/l
1.72
288
2683
12
57
2.12
1.55
1.0
1.0
—
—
—
0
0
0
44
0.00
1.51
0.0
1.6
—
45.76
—
0
5
312
2794
1.17
1.50
1.9
1.8
17.88
19.93
nmol/l
1.76
255
2359
58
428
1.38
1.50
1.6
1.8
1.33
2.19
ug/l
0.53
50
380
18
102
1.78
1.45
1.6
1.2
—
—
—
0
0
553
5875
0.87
1.44
5.1
4.5
—
5942.47
—
0
17
12
59
2.05
1.44
1.3
2.1
6.67
10.03
umol/l
—
6
44
6
22
2.74
1.43
3.2
1.7
55.50
84.45
nmol/24h
—
6
22
35
238
1.49
1.41
2.3
2.2
12.65
12.70
mg/l
0.01
29
215
137
1145
1.23
1.41
1.3
1.4
—
—
—
0
0
141
1183
1.22
1.40
9.6
7.9
5.14
5.11
kpa
0.15
135
1143
17
96
1.78
1.39
2.1
2.0
—
—
—
0
0
141
1184
1.22
1.39
9.6
7.8
11.90
11.94
kpa
0.02
135
1146
140
1175
1.22
1.38
9.6
7.9
1.23
1.03
mmol/l
0.26
118
963
17
97
1.77
1.35
1.6
3.9
—
—
—
0
0
87
694
1.28
1.34
5.6
4.0
—
—
—
0
0
172
1989
0.84
1.34
3.9
4.5
1.02
1.02
kg/l
1.11
126
1346
0
37
0.00
1.34
0.0
8.0
—
496.75
—
0
25
140
1180
1.22
1.33
9.6
7.9
7.42
7.41
ph
0.75
68
690
28
184
1.54
1.33
3.7
2.8
59.75
59.29
%
0.06
28
184
15
83
1.82
1.31
1.1
1.1
—
—
—
0
0
6
24
2.51
1.30
1.3
2.2
137.83
132.67
nmol/l
—
6
24
411
3793
1.14
1.28
2.4
2.5
78.30
78.32
nmol/l
0.00
345
3362
800
7736
1.18
1.24
5.5
5.2
1.37
1.43
mmol/l
3.73
715
7090
5
19
2.64
1.21
1.2
1.1
—
—
—
0
0
59
454
1.32
1.21
3.5
3.4
4.43
4.45
pmol/l
0.05
48
396
624
6534
0.88
1.18
28.7
22.2
13.92
13.77
%
1.86
617
6465
22
141
1.57
1.18
2.3
2.6
—
—
—
0
0
17
102
1.68
1.16
1.6
2.3
0.58
1.08
g/24h
—
10
57
0
33
0.00
1.16
0.0
1.3
—
6.56
—
0
33
237
2118
1.16
1.16
3.1
2.7
6.73
4.96
e6/l
0.69
211
1935
18
110
1.65
1.16
1.1
1.1
0.21
1.53
u/ml
—
9
61
95
782
1.24
1.15
1.6
1.5
—
—
—
0
0
220
1957
1.16
1.14
1.8
1.8
407.74
24766496.13
pmol/l
1.66
178
1603
7
30
2.34
1.12
1.0
1.2
—
—
—
0
0
796
7713
1.16
1.11
5.8
5.4
6.11
6.02
mmol/l
1.02
714
7009
66
523
1.28
1.11
1.3
1.2
—
—
—
0
0
8
41
1.96
1.09
1.1
1.7
39.73
39.72
g/l
—
8
41
803
7792
1.16
1.07
5.6
5.3
4.41
4.50
mmol/l
1.58
728
7193
93
771
1.23
1.07
4.5
4.3
0.06
0.12
%
0.59
31
224
261
2871
0.88
1.06
3.1
3.3
—
—
—
0
0
19
121
1.58
1.06
1.1
1.1
—
—
—
0
0
76
617
1.25
1.06
1.2
1.2
—
—
—
0
0
853
8320
1.18
1.05
14.8
12.6
26.02
25.73
u/l
0.19
827
8070
32
229
1.41
1.04
1.5
1.5
36031.68
14712.73
e6/l
0.32
22
160
19
122
1.57
1.03
1.1
1.1
—
—
—
0
0
97
812
1.22
1.02
4.5
4.3
1.00
0.89
%
0.24
35
262
841
8201
1.17
0.99
27.5
21.8
139.49
139.63
mmol/l
0.77
824
8045
5
23
2.18
0.98
1.4
1.8
36.20
30.43
%
—
5
23
99
838
1.20
0.95
2.0
2.9
66.14
66.33
g/l
0.08
93
770
69
563
1.24
0.94
1.3
1.4
—
—
—
0
0
23
159
1.46
0.92
1.3
1.3
—
—
—
0
0
863
8445
1.17
0.91
29.5
23.8
83.66
82.14
umol/l
0.35
852
8346
834
8141
1.15
0.91
20.0
16.2
—
—
—
0
0
164
1455
1.15
0.90
2.2
2.0
29.71
29.74
s
0.02
157
1410
23
160
1.45
0.89
1.0
1.2
—
—
—
0
0
12
71
1.70
0.89
1.4
1.3
—
—
—
0
0
814
7936
1.14
0.88
6.3
6.0
2.56
2.61
mmol/l
0.75
728
7295
840
8208
1.15
0.88
27.8
21.9
4.00
4.00
mmol/l
0.02
822
8036
15
95
1.59
0.87
1.0
1.1
0.47
0.92
u/ml
—
5
43
8
43
1.87
0.87
3.1
2.6
1572.25
874.35
u/ml
—
8
43
22
153
1.45
0.86
3.0
2.1
0.77
0.86
%
0.44
15
109
24
170
1.42
0.86
4.8
2.9
14.60
8.97
pmol/l
1.13
24
170
45
353
1.29
0.86
1.1
1.1
—
—
—
0
0
204
1844
1.13
0.85
1.4
1.3
3.42
1.47
u/ml
0.43
43
513
17
247
0.68
0.80
5.1
4.8
—
—
—
0
0
349
3266
1.11
0.80
5.7
5.8
1.93
3.20
ug/l
2.74
296
2916
0
27
0.00
0.77
0.0
1.0
—
—
—
0
0
110
961
1.16
0.76
1.3
1.3
—
—
—
0
0
10
59
1.70
0.76
2.1
2.1
6.74
2.23
ug/l
—
5
46
9
53
1.70
0.75
1.6
1.5
82.78
85.19
umol/l
—
9
53
9
53
1.70
0.75
1.2
1.1
—
—
—
0
0
13
83
1.57
0.75
1.6
1.3
7591.50
175567.31
e6/l
—
6
55
12
75
1.61
0.75
1.1
1.1
—
—
—
0
0
5
24
2.09
0.74
1.2
1.7
—
—
—
0
0
19
133
1.44
0.74
3.2
2.0
32.95
32.46
pg
0.19
19
133
5
25
2.00
0.72
1.0
3.3
2.43
1.40
ug/l
—
5
20
6
109
0.55
0.72
2.2
1.6
—
—
—
0
0
6
109
0.55
0.72
2.2
1.6
—
—
—
0
0
6
109
0.55
0.72
2.2
1.6
—
—
—
0
0
6
109
0.55
0.72
2.2
1.6
—
—
—
0
0
9
56
1.61
0.72
1.2
1.1
—
—
—
0
0
9
56
1.61
0.72
3.0
2.4
—
—
—
0
0
104
911
1.16
0.70
3.2
2.6
73.58
67.98
e9/l
0.42
71
689
89
770
1.17
0.70
4.7
4.2
0.53
0.64
%
0.25
34
243
9
58
1.56
0.70
1.4
2.0
15.67
19.55
nmol/l
—
9
50
11
169
0.65
0.69
1.3
1.2
30.14
33.84
u/l
0.09
11
147
872
8572
1.14
0.69
33.8
27.0
91.49
91.45
fl
0.08
862
8469
5
27
1.86
0.68
3.0
1.6
—
—
—
0
0
872
8574
1.14
0.68
33.8
27.0
4.39
4.45
e12/l
2.78
855
8384
872
8574
1.14
0.68
33.7
26.9
30.38
30.40
pg
0.12
862
8468
872
8574
1.14
0.68
34.8
27.6
39.59
40.03
%
1.62
862
8464
872
8575
1.14
0.67
33.9
27.1
6.98
6.87
e9/l
0.71
851
8381
80
690
1.17
0.66
1.7
2.7
—
—
—
0
0
872
8576
1.14
0.66
34.1
27.2
132.23
134.07
g/l
3.04
862
8471
12
78
1.55
0.65
1.0
1.2
—
—
—
0
0
471
4507
1.09
0.64
4.3
4.2
0.00
4.90
estimate
1.07
111
1002
20
146
1.38
0.64
2.4
1.8
2.11
1.64
mmol/l
0.55
20
140
89
778
1.16
0.63
4.9
4.6
0.31
0.09
%
0.37
26
202
21
155
1.36
0.63
1.4
1.4
—
—
—
0
0
871
8571
1.13
0.63
33.9
27.1
246.47
243.49
e9/l
0.66
855
8407
19
256
0.74
0.62
8.8
10.3
—
—
—
0
0
260
2429
1.10
0.61
4.3
3.4
—
0.00
estimate
—
0
13
96
847
1.15
0.61
1.5
1.6
—
—
—
0
0
66
767
0.85
0.61
2.5
2.4
12.00
13.27
nmol/l
0.56
60
683
19
139
1.37
0.60
1.5
1.4
184.00
176.47
au/ml
—
5
39
97
858
1.14
0.60
12.7
9.2
—
—
—
0
0
14
97
1.45
0.59
1.0
1.1
1.92
6.02
u/ml
—
7
55
21
158
1.34
0.57
1.3
1.2
228.54
290.55
u/ml
0.49
13
86
18
241
0.74
0.57
1.3
1.2
—
—
—
0
0
5
89
0.56
0.56
1.4
2.7
2713.60
997.61
mg
—
5
89
10
65
1.54
0.55
1.1
1.1
101.80
99.80
pmol/l
—
10
65
23
295
0.77
0.55
2.2
1.7
—
—
—
0
0
81
716
1.14
0.52
3.9
3.9
87.85
92.27
ng/l
0.24
66
625
17
126
1.36
0.52
1.3
1.1
—
—
—
0
0
10
67
1.50
0.49
1.8
1.7
14.75
16.32
%
—
10
67
246
2316
1.08
0.49
3.5
3.3
0.00
0.03
—
6
62
7
49
1.43
0.46
1.0
1.2
—
—
—
0
0
5
84
0.59
0.45
2.6
2.2
—
—
—
0
0
7
50
1.40
0.45
5.3
3.1
0.71
1.02
index
—
7
50
5
31
1.62
0.43
4.2
3.1
—
—
—
0
0
5
31
1.62
0.43
5.8
1.9
2.40
7.19
nmol/l
—
5
26
6
91
0.66
0.42
1.3
1.2
—
—
—
0
0
5
32
1.57
0.42
1.0
1.5
52.80
88.60
nmol/l
—
5
23
30
249
1.21
0.42
1.3
1.2
—
658.57
titre
—
0
7
21
261
0.80
0.41
2.2
1.8
39.52
41.18
nmol/l
0.15
21
248
5
33
1.52
0.41
1.0
1.2
105.30
159.96
iu/ml
—
5
33
0
16
0.00
0.41
0.0
1.0
—
52.09
—
0
16
8
59
1.36
0.41
1.4
1.7
13.71
14.15
umol/l
—
8
53
106
971
1.10
0.40
3.2
4.2
17.56
25.19
ug/l
0.28
79
811
12
88
1.37
0.40
1.2
1.1
1.50
1.67
nmol/l
—
7
77
5
35
1.43
0.39
1.2
1.3
217.00
173.82
mmol/24h
—
5
35
5
35
1.43
0.39
4.2
2.8
—
—
—
0
0
173
1840
0.93
0.38
5.7
4.8
—
—
—
0
0
459
4451
1.06
0.38
4.3
4.2
0.00
0.00
estimate
-0.00
109
976
50
567
0.88
0.38
1.4
1.4
—
—
—
0
0
131
1218
1.09
0.37
1.8
1.8
—
—
—
0
0
5
37
1.35
0.37
1.8
1.4
—
—
—
0
0
5
37
1.35
0.37
1.0
1.0
1377.00
1442.14
miu/ml
—
5
37
46
403
1.15
0.36
2.1
2.1
—
—
—
0
0
467
4538
1.06
0.35
4.4
4.2
0.04
0.33
estimate
0.43
103
934
28
236
1.19
0.35
1.3
1.2
—
—
—
0
0
6
43
1.40
0.35
1.0
1.6
—
—
—
0
0
24
200
1.20
0.34
1.6
1.8
2.01
35.84
iu/l
0.55
12
74
371
3588
1.05
0.33
3.6
3.7
6.08
6.24
ph
2.23
209
2029
92
847
1.10
0.33
3.2
2.5
29.54
35.20
u/l
1.45
74
708
347
3352
1.05
0.33
5.0
4.2
133.19
112.09
e6/l
0.23
258
2427
179
1887
0.94
0.32
2.8
3.0
2.46
2.46
mmol/l
0.12
156
1700
12
92
1.31
0.32
1.2
1.2
12.50
13.93
u/l
0.17
12
80
212
2220
0.94
0.31
1.4
1.4
—
—
—
0
0
28
240
1.17
0.30
3.8
3.5
0.73
0.83
nmol/l
0.63
23
202
202
1927
1.06
0.30
3.5
3.4
0.97
0.79
ug/l
0.84
128
1288
19
157
1.21
0.29
3.6
2.4
3622.94
2683.36
u/l
—
7
55
7
56
1.25
0.29
1.0
1.3
136.14
150.61
nmol/l
—
7
56
342
3315
1.05
0.28
2.0
1.9
1.40
1.33
mmol/l
0.84
262
2751
36
318
1.14
0.27
1.7
1.9
21.23
21.49
s
0.11
30
292
143
1355
1.06
0.27
1.3
1.3
7.97
9.23
u/ml
0.15
41
486
268
2586
1.05
0.27
4.4
3.4
0.38
0.49
e6/l
0.58
211
1937
284
2746
1.05
0.26
5.3
4.3
7.40
7.40
ph
0.75
211
1999
77
830
0.92
0.26
1.8
1.6
—
—
—
0
0
365
3751
0.96
0.26
17.0
11.8
0.00
0.00
e9/l
1.08
310
3076
5
71
0.70
0.26
2.8
2.5
—
—
—
0
0
157
1494
1.06
0.26
4.0
3.3
1.84
2.14
e6/l
0.29
76
784
40
358
1.12
0.26
3.5
3.9
39.91
68.31
mg/l
0.97
35
307
12
96
1.25
0.24
1.3
1.2
—
87.39
—
0
7
25
217
1.16
0.24
1.1
1.1
—
—
—
0
0
9
77
1.17
0.24
1.4
1.1
—
—
—
0
0
21
244
0.86
0.24
1.1
1.2
0.86
0.92
g/l
0.81
21
244
125
1185
1.06
0.24
2.6
2.6
1.98
1.80
%
0.69
103
1067
5
38
1.32
0.23
1.2
1.1
—
—
—
0
0
5
39
1.28
0.23
1.4
1.2
15.60
27.57
%
—
5
34
30
266
1.13
0.23
1.4
1.4
324.25
278.78
ug/g
0.41
12
158
7
91
0.77
0.22
1.1
2.6
—
—
—
0
0
33
368
0.89
0.22
2.7
3.4
35.93
10610.58
u/ml
0.80
26
314
22
252
0.87
0.22
3.3
3.3
1.80
1.61
mmol/l
0.29
22
245
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
333.16
—
0
5
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
257.60
—
0
5
40
364
1.10
0.20
1.2
1.1
—
91.38
—
0
8
88
830
1.07
0.20
2.1
2.6
4.61
6.74
ug/l
1.31
76
742
0
14
0.00
0.20
0.0
1.9
—
2.46
—
0
14
101
958
1.06
0.20
2.1
2.3
224.78
141.79
ug/g
0.58
76
754
18
155
1.16
0.20
1.6
1.7
—
—
—
0
0
22
193
1.14
0.19
4.9
3.8
61.15
30.84
mg/l
1.14
13
136
11
90
1.22
0.19
2.3
1.8
10.72
10.34
%
0.10
11
90
20
228
0.87
0.19
1.2
1.1
1.41
1.53
g/l
1.62
20
228
259
2525
1.03
0.17
7.3
6.4
—
—
—
0
0
39
359
1.09
0.17
3.5
3.9
45.39
59.95
mg/l
0.41
34
309
21
186
1.13
0.17
1.1
1.4
—
—
—
0
0
12
101
1.19
0.16
14.4
2.5
—
—
—
0
0
8
69
1.16
0.16
1.1
1.1
—
3.09
—
0
14
6
77
0.78
0.15
2.0
2.0
6.20
4.32
mg/l
—
6
72
151
1460
1.04
0.15
1.4
1.3
22.20
32.67
iu/ml
1.02
39
439
10
119
0.84
0.15
1.0
1.4
—
—
—
0
0
31
337
0.92
0.14
1.4
1.6
0.32
0.33
mg/l
0.03
14
161
46
432
1.07
0.13
1.3
1.2
—
—
—
0
0
45
423
1.07
0.13
3.6
2.8
—
—
—
0
0
11
127
0.86
0.12
1.8
1.6
—
—
—
0
0
157
1611
0.97
0.11
4.0
3.2
1.48
1.13
e6/l
0.39
77
899
306
3012
1.02
0.11
4.3
3.6
59.85
87.87
e6/l
0.31
244
2347
10
86
1.16
0.11
1.0
1.1
—
—
—
0
0
57
544
1.05
0.10
2.7
2.5
28.93
23.83
au/ml
—
9
45
12
106
1.13
0.10
1.2
1.2
—
—
—
0
0
12
106
1.13
0.10
2.5
1.8
85.70
89.75
%
0.44
12
106
5
48
1.04
0.09
1.4
1.8
80.40
90.78
ng/l
—
5
48
17
186
0.91
0.09
1.4
1.3
151.16
248.42
miu/ml
—
6
79
11
97
1.14
0.09
1.4
1.4
—
—
nmol/l
—
0
0
67
646
1.04
0.09
1.7
1.5
—
—
—
0
0
104
1012
1.03
0.09
3.2
3.6
7.38
7.38
ph
0.24
52
592
22
204
1.08
0.08
8.7
2.1
—
—
—
0
0
24
257
0.93
0.08
1.0
1.1
—
—
—
0
0
10
113
0.88
0.08
1.3
1.2
—
—
—
0
0
5
61
0.82
0.08
1.2
1.7
—
—
—
0
0
10
88
1.14
0.08
1.0
1.1
—
—
—
0
0
11
98
1.12
0.07
1.2
1.2
—
—
—
0
0
6
72
0.83
0.07
1.2
1.8
8.47
8.47
mmol/l
—
6
72
21
225
0.93
0.07
3.8
1.9
—
—
—
0
0
24
225
1.07
0.07
3.0
2.5
111.53
82.63
ug/min
0.27
17
129
95
974
0.97
0.07
3.3
3.6
1.52
1.89
mmol/l
0.37
87
829
14
153
0.91
0.07
1.4
1.6
—
—
—
0
0
12
132
0.91
0.06
1.1
1.0
—
—
—
0
0
258
2550
1.02
0.06
4.4
4.3
0.00
0.01
estimate
0.78
101
899
9
103
0.87
0.06
1.3
1.3
—
—
—
0
0
48
496
0.97
0.05
1.5
1.8
3.56
3.39
mmol/l
0.44
32
357
19
179
1.06
0.05
4.6
2.0
1.11
0.88
nmol/l
0.66
14
150
67
655
1.02
0.04
15.7
10.2
1.06
1.32
%
3.38
67
650
31
322
0.96
0.04
1.3
1.2
—
1.47
—
0
21
20
210
0.95
0.03
1.1
1.2
—
—
—
0
0
315
3136
1.01
0.02
3.3
3.5
2.35
2.35
mmol/l
0.15
285
2832
23
222
1.04
0.02
8.3
2.1
—
—
—
0
0
44
449
0.98
0.02
3.6
4.0
1.02
1.02
ratio
0.04
37
421
47
479
0.98
0.02
1.2
1.2
87.32
141.52
u/ml
0.88
18
190
10
107
0.93
0.02
1.9
1.7
—
—
—
0
0
12
127
0.94
0.01
1.3
1.4
—
—
—
0
0
18
173
1.04
0.01
10.1
2.0
—
—
—
0
0
23
223
1.03
0.01
8.3
2.1
—
—
—
0
0
49
497
0.99
0.01
1.8
1.7
—
—
—
0
0
13
124
1.05
0.00
1.0
1.3
23798.57
87873.53
e6/l
—
7
64
14
134
1.05
0.00
1.1
1.1
—
—
—
0
0
17
174
0.98
0.00
1.3
1.1
—
—
—
0
0
340
3395
1.00
0.00
4.1
4.2
0.06
0.03
estimate
0.35
94
820
15
153
0.98
0.00
15.6
2.8
—
—
—
0
0
21
207
1.01
0.00
2.8
3.4
7.47
7.77
mmol/l
0.23
21
201
73
733
1.00
0.00
6.5
3.8
1.22
1.23
mmol/l
0.05
61
629
33
325
1.02
0.00
3.9
3.7
1.44
3.63
ratio
1.27
22
195
23
225
1.02
0.00
1.5
1.6
—
—
—
0
0
23
225
1.02
0.00
8.5
2.1
—
—
—
0
0
10
95
1.05
0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
0.50
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
13.63
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
69.60
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
7
77
0.91
-0.00
1.1
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
51
0.98
-0.00
1.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
85
0.94
-0.00
1.4
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
71.11
—
0
9
8
85
0.94
-0.00
1.5
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
69
1.01
-0.00
1.1
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
7.24
—
0
9
0
7
0.00
-0.00
0.0
5.7
—
0.36
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
86
0.93
-0.00
1.5
1.6
—
—
—
0
0
8
86
0.93
-0.00
1.4
1.8
—
—
—
0
0
8
85
0.94
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
78
0.90
-0.00
1.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H8_MASTCHRON and mortality.

Females

Parameter HR [95% CI] p-value
H8_MASTCHRON 1.062 [0.92, 1.23] 0.423
Birth year 0.993 [0.98, 1.0] 0.116

During the follow-up period (1.1.1998 — 31.12.2019), 301 out of 1336 females with H8_MASTCHRON died.

Males

Parameter HR [95% CI] p-value
H8_MASTCHRON 1.065 [0.91, 1.24] 0.417
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 353 out of 1435 males with H8_MASTCHRON died.

Mortality risk

Mortality risk for people of age

years, who have H8_MASTCHRON.

N-year risk Females Males
1 0.084% 0.166%
5 0.55% 1.315%
10 1.418% 3.106%
15 2.849% 5.996%
20 5.255% 10.158%

Relationships between endpoints

Index endpoint: H8_MASTCHRON – Chronic mastoiditis

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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